Title of Invention	SYNTHESIS OF 3,6 - DIALKYL - 5,6 - DIHYDRO -4- HYDROXY-2H-PYRAN-2-ONE
Abstract	The present invention relates to a novel process for producing a 8-lactone of the formula: using an acyl halide of the formula: wherein R1, R2 R3 and X are described herein, as well as novel intermediates. In particular, the present invention relates to a process for enantioselectively producing the 8-lactone.

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The present invention is directed to a process for producing 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one. In particular, the present invention is directed to an enantioselective process for producing the same. 5-Lactones such as 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-ones are useful intermediates in the preparation of a variety of fine chemicals and pharmaceutically active compounds. For example, 5,6-dihydro-3-hexyl-4-hydroxy-6-undecyl-pyran-2-one is a well known precursor for the preparation of oxetanones such as tetrahydrolipstatin (orlistat). See for example, U.S. Patent Nos. 5,245,056 and 5,399,720, both issued to Karpf et al.; and U.S. Patent Nos. 5,274,143 and 5,420,305, both issued to Ramig et al. Other methods of preparing tetrahydrolipstatin use aβ -hydroxy ester, e.g., methyl 3-hydroxy tetradecanoate, as an intermediate. See for example, Pommier et al., Synthesis, 1994, 1294-1300, Case-Green et al, SynletL, 1991,781-782, Schmid et al, Proceedings of the Chiral Europe '94 Symposium, September 19-20,1994, Nice, France, and the above mentioned U.S. Patents. Some methods of preparing oxetanones, such as those disclosed in the above mentioned U.S. Patents issued to Karpf et al., use a P-hydroxy ester as an intermediate to prepare the 5-lactone which is then used in the synthesis of oxetanones. The stereochemistry of a molecule is important in many of the properties of the molecule. For example, it is well known that physiological properties of drugs having one or more chiral centers, i.e., stereochemical centers, may depend on the stereochemistry of a drug's chiral center(s). Thus, it is advantageous to be able to control the stereochemistry of a chemical reaction. Many oxetanones, e.g., tetrahydrolipstatin, contain one or more chiral centers. Intermediates 5-lactone and p-hydroxy ester used in the synthesis of tetrahydrolipstatin contain one chiral center. Some syntheses of these intermediates, such as those disclosed in the above mentioned U.S. Patents issued to Karpf et al., are directed to the preparation of a racemic mixture which is then resolved at a later step to isolate the desired isomer. Other methods are directed to an asymmetric synthesis the β-hydroxy ester by enantioselectively reducing the corresponding β-ketoester. Moreover, in order to achieve a high yield of the desired product, some current asymmetric hydrogenation processes for reducing methyl 3-oxo-tetradecanoate require extremely pure reaction conditions, e.g., hydrogen gas purity of at least 99.99%, thus further increasing the cost of producing the correspondingβ-hydroxy ester. Therefore, there is a need for a process for producing 8-lactones. And there is a need for enantioselectively reducing P-ketoesters under conditions which do not require extremely pure reaction conditions or high hydrogen gas pressure. In more detail, the present invention is directed to a process for the preparation of a 5-lactone of the formula (I): followed by treating said 5-hydroxy-protected-p-enol ether ester with an acid to produce said 5-lactone, wherein in the above formulae R1 is C1-C20 alkyl; R is H or C1-C10 alkyl; R is a hydroxy protecting group; R4 and R5 in formulae (III) and (IV) are independently C1-C6 alkyl, C5-C30 aryl, C6-C20 arylalkyl or -SiR8R9R10, wherein R8, R9, R10is independentlyC1-C6 alkyl or phenyl; R5 in formulae (V) and (VI) is C1-C6 alkyl, C5-C20 aryl, or C6-C2o arylalkyl; R5 is C1-C6 alkyl, C5-C20 aryl or C6-C20 arylalkyl; R6 is H or R4; R7 is H or R3, and X is a halide. As used herein, the term "treating", "contacting" or "reacting" refers to adding or mixing two or more reagents under appropriate conditions to produce the indicated and/or the desired product. It should be appreciated that the reaction which produces the indicated and/or the desired product may not necessarily result directly from the combination of two reagents which were initially added, i.e., there maybe one or more intermediates which are produced in the mixture which ultimately leads to the formation of the indicated and/or the desired product. The term "alkyl" refers to aliphatic hydrocarbons which can be straight or branched chain groups. Alkyl groups optionally can be substituted with one or more substituents, such as a halogen, alkenyl, alkynyl, aryl, hydroxy, amino, thio, alkoxy, carboxy, oxo or cycloalkyl. There may be optionally inserted along the alkyl group one or more oxygen, sulfur or substituted or unsubstituted nitrogen atoms. Exemplary alkyl groups include methyl, ethyl, /-propyl, n-butyl, t-butyl, fluoromethyl, difluoromethyl, trifluoromethyl, chloromethyl, trichloromethyl, pentyl, hexyl, heptyl, octyl, decyl and undecyl. The term "aryl" refers to monocyclic or bicyclic carbocyclic or heterocyclic aromatic ring moieties. Aryl groups can be substituted with one or more substituents, such as a halogen, alkenyl, alkyl, alkynyl, hydroxy, amino, thio, alkoxy or cycloalkyl. Exemplary aryl groups include phenyl, toluyl, pyrrolyl, thiophenyl, furanyl, imidazolyl, pyrazolyl, 1,2,4-triazolyl, pyridinyl, pyrazinyl, pyrimidinyl, pyridazinyl, thiazolyl, isothiazolyl, oxazolyl, and isoxazolyl. The present invention provides a process for the preparation of 8-lactones, such as 3,6-dialkyl-5,6-dihydro-4-hydroxy-2H-pyran-2-ones. In particular, the present invention provides a process for the preparation of a 5-lactone of the formula: 1 T where R is C1-C20 alkyl, and R isH or Q-C10 alkyl. In particular, the present invention provides a process for enantioselectively producing the 5-lactone I. In one specific embodiment of the present invention, the enantioselective process provides (i?)-S-lactone VII having the following stereocenter: It should be appreciated that the 8-lactone of formula VII and the corresponding enantiomerically enriched 8-lactone VII may also exist in, or are in equilibrium with, their tautomeric forms: ] respectively. Therefore, any reference to the 5-lactone of formula I or VII implicitly includes its tautomeric form of formula IC or ID, respectively. In a preferred embodiments of the invention, R isundecyl, R ishexyl, R is a moiety of the formula -SiRllR12R13, wherein each of Ru, R12 and R13 is independentlyC1-C6 alkyl or phenyl, X is chloride, R5 is C1-C6alkyl, each of R4 and R6 is a moiety of the formula -SiR8R9R10 and R7 is H. One embodiment of the present invention provides a process for the preparation of a 8-lactone of the formula (I): followed by removing at least one of the protecting groups R* and R6; and contacting the product with an acid to produce the 8-lactone, where R is C1-C20 alkyl; R is H or C1-C10alkyl; R* is a hydroxy protecting group; each of R4 and R5 is independently d-C6 alkyl, C5-C20 aryl, C6-C20 arylalkyl or -SiR8R9R10; R6 is H or R4; each of R8, R9, R10 is independently C1-C6 alkyl or phenyl; and X is a halide. Another embodiment of the present invention provides a process for the preparation of the 8-lactone of formula (I) described above comprising treating an acyl halide of the formula (II): followed by treating the 8-hydroxy-protected-(5-enol ether ester with an acid to produce the 8-lactone, where R1, R2, R3, R5, and X are those described above, and R7 is H or R3. Preferably, methods of the present invention provides an enantioselective synthesis of the 5-lactone. The process of step a) comprises treating said 8-hydroxy-protected-P-enol ether ester to remove R protecting group to produce a 8-hydroxy-protected-P-ketoester of the formula: and (ii) treating said p-hydroxy-protected ester with an acyl halogenating agent to 1 A "3 produce said acyl halide, wherein R is H, R' or a carboxylate counter cation. In the process each of R3 and R14 maybe a moiety of the formula -SiR15Rl6R17, wherein each of R15, R16 and R17 is independently C1-C6 alkyl or phenyl. The process may further comprise the step of enantioselectively producing saidβ-hydroxy acid, wherein said P-hydroxy acid producing step comprises: The resulting 8-lactone having preferably has the following stereochemical configuration: wherein said process produces said 8-lactone in an enantiomeric excess of at least about 90%. In a preferred embodiment of the invention said step of enantioselective reduction of said p-ketoester comprises hydrogenation of said P-ketoester in the presence of a hydrogenation catalyst. Suitable hydrogenation catalysts are described below or may be selected from the catalysts as shown in Table 2. Preferably, said hydrogenation catalyst is a compound of the formula RuCl2((i?)-MeOBIPHEP). The hydrogenation catalyst maybe the product produced by contacting a ruthenium diacetate compound of the formula Ru(OAc)2((-R)-MeOBIPHEP) with a halide source. The molar ratio of between said halide source and said ruthenium diacetate should at least about 20:1. Preferably the process for enantioselective preparation of a P-hydroxy ester of the formula: in the presence of about 40 bar of pressure or less of hydrogen gas and a ruthenium hydrogenation catalyst comprising a halide and a chiral substituted biphenyl phosphorous ligand, wherein R is C1-C20 alkyl, and R18 is H or C1-C6 alkyl, C5-C20 aryl or C6-C2o arylalkyl. Technical grade hydrogen is suitable for this process. In the above process, R1 is preferably undecyl and R18 is preferably C1-C6 alkyl.The hydrogenation catalyst maybe selected form the catalysts as defined above.. A further preferred embodiment of the present invention refers to a process for enantioselectively producing a 8-lactone of the formula (VII): said process comprising: (a) treating an acyl halide of the formula: (b) treating said 8-siloxy-p-silyl enol ether ester with a base to remove at least one silyl group; and (c) contacting the product of said step (b) with an acid, e.g. hydrochloric acid to produce said S-lactone, wherein R isC1nH23>R isC6Hi3, R is C1-C6 alkyl, C5-C2o aryl or C6-C20 arylalkyl; and each of R8, R9, R10, R11, R12 and R13 is independently C1-C6 alkyl or phenyl. Said process produces said 8-lactone in an enantiomeric excess of at least about 90%. Preferably R5 is C1-C6 alkyl. In a preferred embodiment step (b) comprises treating said 8-siloxy-p-silyl enol ether ester with a base selected from the group consisting of hydroxides and carbonates to desilylate both silyl groups. More preferably said step (b) comprises treating said 8-siloxy-p-silyl enol ether ester with a bicarbonate to produce a 8-siloxy-P-ketoester of the formula: and (ii) contacting said p-siloxy tetradecanoate silyl ester with an acyl halogenating agent, e.g. thionyl chloride, to produce said acyl halide. Preferably, R11, R12 and R13 are methyl and said silylating agent is selected from the group consisting of trimethylsilyl chloride and hexamethyldisilazane. The process described above may further comprise the step of producing said (J?)-3-hydroxy tetradecanoic acid, wherein said (JR)-3-hydroxy tetradecanoic acid producing step comprises: wherein R1 is C1-C6 alkyl, C5-C20 aryl or C6-C20 arylalkyl; and (B) saponifying said P-hydroxy ester to produce said (£)-3-hydroxy tetradecanoic acid. The step of enantioselective reduction of said f}-ketoester comprises hydrogenation of said p-ketoester in the presence of a hydrogenation catalyst as described above. Another preferred embodiment of the present invention refers to the preparation of a 5-lactone of the formula (VII): (b) contacting said 8-hydroxy-[3-ketoester with an acid to produce said 8-lactone, wherein R isCnH23>R isQHu, R isC1-C6alkyl, C5-C2oaryl or C6-C2o arylalkyl; and each of Rn, R12 and R13 is independently C1-C6 alkyl or phenyl. This process should produce said 8-lactone in an enantiomeric excess of at least about 90%. Preferably R5 is Q-Ce alkyl and said acid is hydrochloric acid. The acyl halide may be produced as described above. In another embodiment of the present invention the processes described maybe used for the preparation of lipase inhibitors, e.g. tetrahydrolipstatin (orlistat, Formula XI). Such a process may comprise the steps of * d) followed by deprotection and reaction with N-formyl-S-leucin under Mitsunobu conditions to obtain a compound of formula (XI) wherein R1 is Q-C20 alkyl; R2 is H or C1-C10 alkyl; R5 is C1-C6 alkyl, C5-C20 aryl or C6-C2o arylalkyl; each of R8> R9, R10, R11, R12 and R13 is independently C1-C6 alkyl or phenyl; and X is a halide. Preferrred compounds are (R)-3-trimethylsiloxy tetradecanoyl chloride, methyl (R)-3,5-bis-(trimethylsiloxy)-2-hexyl-3-hexadecenoate, ethyl (J?)-3,5-bis-(trimethylsiloxy)-2-hexyl-3-hexadecenoate, methyl (5i?)-5-(trimethylsiloxy)-2-hexyl-3-oxo-hexadecanoate, and ethyl (5i?)-5-(trimethylsiloxy)-2-hexyl-3-oxo-hexadecanoate. A further embodiment of the present invention refers to the use of the described processes for the preparation of tetrahydrolipstatin (orlistat). The invention refers also to compounds prepared by any of the processes as described. One embodiment of the present invention provides a process for the preparation of a 8-lactone of the formula: (b) removing at least one of the protecting groups R3 and R6; and (c) contacting the product of the step (b) with an acid to produce the 8-lactone, where R is C1-C2o alkyl; R isH or C1-C10 alkyl; R is a hydroxy protecting group; each of R4 and R5 is independently C1-C6 alkyl, C5-C2o aryl, C6-C2o arylalkyl or - SiR8R9R10; R6 is H or R4; each of R8, R9, R10 is independently d-C6 alkyl or phenyl; and X is a halide. The present invention will now be described in reference to the syntheses of enantiomerically enriched 8-lactone VII. It should be appreciated that the racemic form of 5-lactone VII or 5-lactone having the opposite stereochemical configuration as that of formula IA, while not explicitly discussed herein, can be readily prepared using the processes of the present invention by using a racemic mixture or opposite stereochemically configured starting materials, respectively. In one embodiment of the process of the present invention, the process includes treating an acyl halide of the formula: with a ketene acetal of the formula: 111 under conditions sufficient to produce a 8-hydroxy-protected-P-enol ether ester of the formula: where R1 and R2 are described above; R3 is a hydroxy protecting group; each of R4 and R5 is independently C1-C6 alkyl, C5-C2o aryl (preferably C6-C2o aryl), C6-C2o arylalkyl (preferably C7-C20 arylalkyl) or a moiety of the formula -SiR8R9R10; R6 is H or R4; X is halide, preferably chloride; and each of R8, R9 and R10 is independently C1-C6 alkyl or phenyl. A variety of protecting groups, including protecting groups for hydroxy and carboxylic acid functional groups, are known in the art, and can be employed. Examples of many of the possible protecting groups can be found in Protective Groups in Organic Synthesis, 3rd edition, T.W. Greene and P.G.M. Wuts, John Wiley & Sons, New York, 1999, which is incorporated herein by reference in its entirety. With reference to compounds described above (Formulae I, VII, IC, ID, Ila, III, IVa): Preferably, R is undecyl. Preferably, R is C1-C10 alkyl, more preferably hexyl. Preferably, R3 is a moiety of the formula -SiRllR12R13, where each of Ru, R12 and R13 is independently Ci-C6 alkyl or phenyl, more preferably each of Ru, R12 and R13 is independently methyl, isopropyl, tert-butyl or phenyl. More preferably R3 is a moiety of the formula -Si(CH3)3. Preferably, R4 is a moiety of the formula -SiR8R9R10. Preferably each of R8, R9 and R10 is independently methyl, isopropyl, tert-butyl or phenyl. More preferably R4 is a moiety of the formula -Si(CH3)3. Preferably, R5 is C1-C6 alkyl, C5-C20 aryl or C6-C2o arylalkyl. More preferably R5 is CrC6 alkyl. Still more preferably R5 is methyl or ethyl. Preferably, R6 of compound IVa is same as R4 of compound IV, particularly when R4 is a moiety of the formula -SiR R R . Processes of the present invention also include treating 8-hydroxy-protected-P-enol ether ester IVa under reaction conditions sufficient to remove at least one of the protecting groups (i.e., R and/or R , preferably at least R ) and contacting the resulting deprotected compound with an acid to produce the 5-lactone VII. A particularly useful ketene acetal III is a silyl ketene acetal in which R4 is a moiety of the formula -SiR8R9R10 and R5 is C1-C6alkyl, C5-C20 aryl or C6-C20 arylalkyl. Silyl ketenes can be readily prepared by any of the currently known methods. Some of the methods for preparing silyl ketenes are disclosed in Miura et al., Bull Chem. Soc. Jpn., 1991, 64, 1542-1553; Umemoto and Gotoh, Bull. Chem. Soc Jpn.y 1987, 60, 3823-3825; Sugimoto et al., Chem. Lett., 1991,1319-1322; Miura et al, Bull Chem. Soc. Jpn., 1992, 65, 1513-1521; and Shono et al., /. Org. Chem.y 1984,49, 1056-1059, which are incorporated herein by reference in their entirety. The silyl ketene acetal III can be prepared from the corresponding ester (i.e., a compound of the formula R -CH2-C(=0)OR ) by treating the ester with a strong base such as lithium hexamethyl disilazide (LiHMDS), a dialkylamide, e.g., lithium diisopropylamide and lithium tetramethylpiperidine (LiTMP), in a conventional aprotic organic solvent, such as tetrahydrofuran (THF), hexane, dimethoxy ethane (DME), ether or mixtures thereof, to generate an enolate and trapping (i.e., contacting) the enolate with a silylating agent, including a silyl triflate and silyl halide, such as silyl chloride, e.g., trimethylsilyl chloride. Dialkylamide can be prepared by treating the corresponding dialkylamine with a strong base, such as an alkyl lithium (e.g., butyl lithium) in a conventional aprotic organic solvent described above. The preparation of silyl ketene acetal III is generally carried out under preferably an inert atmosphere such as nitrogen, argon, helium or the like, at a# temperature preferably at or less than about 0 °C, more preferably at or less than about -30 °C, and most preferably at about -78 °C. The silyl ketene acetal III can be purified, e.g., by distillation under a reduced pressure. When R' is C1-C10alkyl and IT and RD are different moieties, the resulting silyl ketene acetal III can have two different geometric isomers, i.e., E- or Z-double bond configuration. It should be appreciated that since the carbon atom of 5-lactone VII containing R2 group is not a chiral-center (or the chirality is not significant because it can be readily isomerized), the geometric isomer of the silyl ketene acetal is not important for enantioselective processes of the present invention. In one particular embodiment of the present invention, the 5-hydroxy-protected-P-enol ether ester V, where R is R4, is prepared by reacting the above described silyl ketene acetal III with the acyl halide III, where R3 is a moiety of the formula -SiRuRl2R13. The reaction is typically carried out in a conventional aprotic organic solvent, such as THF, toluene, heptane, hexane or mixtures thereof, in the presence of a tertiary amine including trialkyl amine, such as triethyl amine or tributyl amine, under preferably an inert atmosphere described above. Preferably, the reaction temperature is in the range of from about 0 °C to about 25 °C The crude 5-hydroxy-protected-p-enol ether ester IVa can be purified, e.g., by distillation under a reduced pressure or by chromatography, or it can be used directly in the next step without any purification. As used herein, a "crude" compound refers to a compound which is not subject to a separate purification step other then a conventional work-up of the reaction. The resulting 8-hydroxy-protected-p-enol ether ester V, in particular where R and R6 are a moiety of the formula -SiRuR12R13 and -SiR8R9R10, respectively, can be selectively i monodesilylated to produce a 8-siloxy-P-ketoester of the formula: under acidic or basic conditions, preferably under basic conditions. For basic monodesilylation conditions, typically a tertiary amine including a trialkylamine, such as triethylamine or preferably tributylamine; or a bicarbonate, such as potassium bicarbonate, lithium bicarbonate or preferably sodium bicarbonate, is used. The monodesilylation reaction can be conducted in a protic solvent, such as alkyl alcohol (e.g., methanol, ethanol and isopropanol), or a mixture of aprotic organic solvent and a protic solvent (e.g., alkyl alcohol or water). Exemplary aprotic organic solvents which are useful in * monodesilylation reaction include methylene chloride, dimethyl formamide (DMF), dimethyl sulfoxide (DMSO), THF and ether. Preferably, the monodesilylation reaction is carried out in an alkyl alcohol solvent, more preferably in methanol. The monodesilylation reaction temperature range is preferably from about 0 °C to about 25 °C. The 8-siloxy-P-ketoester Via can be further desilylated under acidic or basic conditions, preferably under acidic conditions, and cyclized to produce the 5-lactone VII. Desilylation of a hydroxy group is well known to one of ordinary skill in the art and is disclosed in the above mentioned Protective Groups in Organic Synthesis, For acidic desilylation conditions, typically an acid such as hydrochloric acid, sulfuric acid, phosphoric acid, acetic acid, or trifluoroacetic acid is used. Desilylation of the 5-siloxy-P-ketoester Via under an acidic condition results in a rapid cyclization to produce the 5-lactone VII, thus eliminating a need for a separate cyclization step. Altenatively, the 8-lactone VII can be produced by removing both of the protecting groups (R3 and R6) from the 5-hydroxy-protected-p-enol ether ester IVa in a single step and contacting the deprotected product with an acid under conditions sufficient to produce the 5-lactone VII. As used herein, the term "single step" refers to removal of both protecting groups R3 and R6 under same reaction conditions. In a particular embodiment of the present invention, where R and R1 of 5-hydroxy-protected-p-enol ether ester IVa are moieties of the formula -SiRnR12R13 and -SiR8R9R10, respectively, it is preferred that both of the silyl groups are removed in a single step under a basic condition, typically using a hydroxide or preferably a carbonate. Exemplary hydroxides which can be used in the present invention include sodium hydroxide, potassium hydroxide, lithium hydroxide, calcium hydroxide and magnesium hydroxide. Exemplary carbonates which are useful in the present invention include potassium carbonate, lithium carbonate, sodium carbonate and cesium carbonate. Preferred carbonate is potassium carbonate. A single step removal of both silyl groups can be carried out in a same solvent as those described above for monodesilylation. The reaction temperature range of a single step desilylation and subsequent production of the 5-lactone VII is preferably from about 0 °C to about 25 °C. Typically, the 5-lactone VII is produced by adjusting the pH of the reaction mixture to from about pH 3 to about pH 5. Any acid which is capable of providing the above described pH range of the reaction mixture may be used, such acids include, but are not limited to, hydrochloric acid, sulfuric acid, and phosphoric acid. In one particular embodiment of the present invention, hydrochloric acid is used to produce the 5-lactone. The 5-lactone VII thus formed typically precipitates from the reaction mixture, e.g., when methanol is used as the solvent. The 5-lactone VII can be further purified, e.g., by recrystallization, to obtain higher purity and/or higher enantiomeric excess of 5-lactone VII. In another embodiment of the present invention, the acyl halide Ha is treated with a malonate half acid of the formula: U Via where R1, R2 and R5 are described above, and R7 is H or R". Preferably, R7 is H. The process of the present invention also includes contacting the S-hydroxy-(3-ketoester Via with a base or preferably an acid under conditions sufficient to produce the 5-lactone VII, as described above. The reaction between the acyl halide Ha and the malonate half acid V is typically carried out in the presence of a metal coordinating agent and a tertiary amine base. See for example, Rathke and Cowan, /. Org. Chem., 1985,50,2622-2624, and Clay et al., Synthesis, 1993, 290-292, which are incorporated herein by reference in their entirety. The reaction can be conducted under an aprotic organic solvent, such as n-butyl ether, THF, acetonitrile, methylene chloride, dimethoxyethane (DME), methyl t-butyl ether (MTBE), toluene, 2-methyl tetrahydrofuran (2-Me-THF), with THF being the preferred solvent. Without being bound by any theory, it is believed that the use of a metal coordinating agent generates a metal enolate of the malonate half acid VII, which is sufficiently reactive to react with the acyl halide III, but is not basic enough to deprotonate the initially formed product, which contains an acidic proton. In general, the reaction between the acyl halide Ila and the malonate half acid V is conducted by adding the acyl halide III, preferably in a solution, to a solution mixture which includes the malonate half acid VII, the metal coordinating agent and the tertiary amine base. Higher yield of the 8-hydroxy-P-ketoester Via can be obtained by using at least about 2 equiv. of a relatively non-nucleophilic base, such as a tertiary amine, and at least 1 equiv. of the metal coordinating agent relative to the amount of malonate half acid VII. Exemplary metal coordinating agents include magnesium salts including magnesium halides, such as MgCl2, MgBr2 and Mgl2; manganese salts, such as manganese halides and manganese acetates; lithium salts, such as lithium halides; samarium salts, such as samarium halides; and mixtures of sodium and lithium salts, such as mixtures of sodium halides and lithium halides. Preferably, the metal coordinating agent is a magnesium salt, more preferably magnesium chloride. Exemplary tertiary amine bases which are useful in the present invention include trialkylamines, such as triethylamine, diethylisopropylamine and tributylamine; and other tertiary amines. Preferably, the tertiary amine base is a trialkylamine, more preferably triethylamine, diethylisopropylamine or tributylamine. Typically, the reaction between the acyl halide Ila and the malonate half acid V is conducted at a temperature ranging from about 0 °C to about 35 °C, under preferably an inert atmosphere as those described above. Preferably, the reaction is conducted at about 25 °C. The resulting 8-hydroxy-p-ketoester Via can be isolated or preferably used directly without isolation and treated with an acid under conditions sufficient to produce the 8-lactone VII. For example, after reacting the acyl halide Ila with the malonate half acid VII, an acid described above is added to the resulting reaction mixture, which results in the formation of the 8-lactone VII. Preferably, alkyl malonate half acid V is methyl malonate half acid VII, where R5 is methyl, as the methyl 8-hydroxy-p-ketoester Via produces the 8-lactone VII in higher yield than other malonate half acid V under similar reaction conditions and time. One can take advantage of this higher yield by methyl malonate half acid V by converting a non-methyl malonate half acid V to methyl malonate half acid VII, and then reacting the methyl malonate half acid V with the acyl halide Ila to produce the 8-lactone VII. For example, ethyl malonate half acid VII, where R5 is ethyl, can be reacted with a metal methoxide, such as sodium methoxide, in methanol under conditions sufficient to produce the methyl malonate half acid V from ethyl malonate half acid VII, and then reacting the resulting methyl malonate half acid V with acyl halide Ha to produce the 8-lactone VII. Alternatively, the product of a reaction between non-methyl malonate half acid V and the acyl halide Ila can be converted to its corresponding methyl 8-hydroxy-P-ketoester Via prior to contacting with an acid or preferably in situ during the cyclization step to produce the5-lactoneVII. The malonate half acid VII, where R is not H, can be prepared by a variety of methods. For example, malonate half acid V can be prepared by treating malonate diester, e.g., R5OC(=0)CH2C(=0)OR5, with a base, such as sodium ethoxide, to generate the corresponding enolate and contacting the enolate with an alkyl group containing a leaving group, for example, mesylate, tosylate and halides such as bromide and iodide, to produce an alkyl malonate diester, i.e., R5OC(=0)CH(R2)C(=0)OR5. The alkyl malonate diester is then monosaponified, typically using less than about 1 equiv., preferably about 0.9 equiv. of hydroxide in the corresponding R5 alcohol solvent to produce the malonate half acid VII, for example, by treating with a hydroxide, such as potassium hydroxide, sodium hydroxide or lithium hydroxide, in methanol (when R5 is methyl) or ethanol (when R5 is ethyl). Processes of the present invention can also include the step of producing the acyl halide Ila from a p-hydroxy acid or salts thereof, such as potassium or sodium salts, of the formula: by protecting the hydroxy group to produce a P-hydroxy-protected ester of the formula: and contacting the p-hydroxy-protected ester Xa with an acyl halogenating agent under conditions sufficient to produce the acyl halide III, where R1 and R" are described above and R14 is H, R3 or a carboxylate counter cation. As used herein, the term "carboxylate counter cation1' refers to a counter ion of the carboxylic salt of formula Xa. Exemplary carboxylate counter cations include metal cations, such as sodium, lithium and potassium; ammonium; mono-, di-, tri- and tetra-alkyl ammonium; pyridinium; and other suitable cations for carboxylic anions which are known to one of ordinary skill in the art. In one particular embodiment of the present invention, the acyl halide Ila is produced by contacting the p-hydroxy acid IXa with a silylating agent to produce a p-silyloxy silyl ester of the formula: and contacting the P-silyloxy silyl ester XIa with an acyl halogenating agent, where R , R and R13 are those described above. Any hydroxy silylating agent known in the art can be used to produce the p-silyloxy silyl ester XI. Exemplary silylating agents include compounds of the formula X'-SiR11^13, where R11, R12 and R13 are described above and X1 is a halide or triflate; and hexamethyldisilazane (when Ru, R12 and R13 are methyl). 11 11 For example, P-trimethylsiloxy trimethyl silyl ester of compound XI, where R , R and R13 are methyl, can be prepared by treating the p-hydroxy acid with t chlorotrimethylsilane (TMSC1) in the presence of pyridine preferably under an inert atmosphere described above. The reaction is preferable conducted in an aprotic organic solvent such as methylene chloride, MTBE, toluene and THF, with THF being a particularly preferred solvent. The temperature range of the reaction is generally from about 0 °C to about 25 °C, preferably the reaction temperature is about 25 °C. The reaction can also include 4-dimethylaminopyridine (DMAP) or other silylating catalyst known to one of ordinary skill in the art. When a silylating catalyst such as DMAP is present, it is typically used at about 1 mole %. Even without the presence of a silylating catalyst, silylation is typically complete within few hours, generally within about 2 hours at room temperature. Alternatively, the P-trimethylsiloxy trimethyl silyl ester XIa can be prepared by using hexamethyldisilazane (HMDS). For example, heating a mixture of P-hydroxy acid IXa and HMDS in an aprotic organic solvent, such as toluene or preferably THF, produces the P-trimethylsiloxy trimethyl silyl ester XI. When HMDS is used, one of the by-products of the reaction is ammonia, which can be readily removed by partially distilling the reaction solvent typically at atmospheric pressure. The resulting partially concentrated solution of P-trimethylsiloxy trimethyl silyl ester XIa can be used directly in the acyl halide Ha producing step without further purification. A variety of acyl halogenating agents are known to one of ordinary skill in the art. Exemplary acyl halogenating agents and general procedures for using the same are disclosed, for example, in "Comprehensive Organic Synthesis," vol. 6, Trost, Fleming and Winterfeldt eds., Pergamon Press, 1991, pp. 301-319, and "The Chemistry of Acyl Halides," Patai, ed., Interscience Publishers, 1972, pp. 35-64, which are incorporated herein by reference in their entirety. It has been found by the present inventors that P-hydroxy-protected ester X, in particular P-trimethylsiloxy trimethyl silyl ester XI, can be readily converted to the acyl halide Ila using oxalyl chloride or thionyl chloride in an aprotic organic solvent, such as toluene or preferably THF. When using oxalyl chloride as the acyl halogenating agent, pyridine and a catalytic amount of silylating catalyst such as DMF is typically used. However, when thionyl chloride is used as the acyl halogenating agent in place of oxalyl chloride, a need for using a silylating catalyst such as DMF is eliminated. In either case, formation of pyridinium salts in acyl halogenation reaction may complicate the reaction between the ketene acetal III and the acyl halide III. To avoid possible complications in the reaction between the ketene acetal III and the acyl halide III, typically pyridinium salts are removed from the reaction mixture, e.g., by filtration. The resulting reaction mixture is then further concentrated, e.g., by distillation, which also removes at least a portion of any residual TMSC1, thionyl chloride and THF. The distillation is generally conducted under a reduced pressure at about 0 °C. It has been found by the present inventors that when HMDS is used as the silylating agent for P-hydroxy acid IXa in THF, the subsequent acyl halogenation reaction with thionyl chloride in THF is slow at 0 °C and gives poor yields at higher reaction temperatures. However, a presence of pyridinium salts, such as pyridinium hydrochloride, pyridine or DMAP increases the reaction rate and yields higher amounts of the desired acyl halide III. Thus, when HMDS is used as the silylating agent, pyridine is typically added to the subsequent acyl halogenation reaction. The amount of pyridine added is generally from about 1 mole% to about 10 mole%, and preferably about 2 mole%. The halogenation reaction is conducted at a reaction temperature of typically about 0 °C. Processes of the present invention can also include enantioselective preparation of P-hydroxy acid IXa from a p-ketoester of the formula: by enantioselectively reducing the ketone carbonyl of the P-ketoester XII and saponifying the ester group to produce the p-hydroxy acid IXa, where R1 is described above and R18 is Q-Cfi alkyl, C5-C20 aryl or C6-C20 arylalkyl. Preferably R18 is Q-Ce alkyl, more preferably methyl or ethyl. In one particular embodiment of the present invention, an enantioselective preparation of P-hydroxy ester IXa involves hydrogenation of the P-ketoester XII in the presence of a chiral hydrogenation catalyst. It should be appreciated that a non-chiral hydrogenation catalyst will result in racemic mixture of p-hydroxy ester IXa , and a chiral hydrogenation catalyst having an opposite configuration as those described below will result in p-hydroxy ester having an opposite configuration as that shown in Figure IXa . Specifically, the present invention provides a process for enantioselectively reducing the p-ketoester XII using an enantiomerically enriched hydrogenation catalyst, i.e., hydrogenation catalyst having greater than about 97 % enantiomeric excess (%ee). In one particular embodiment of the present invention, the chiral hydrogenation catalyst comprises a ruthenium catalyst containing a chiral ligand such as those shown in the Examples section, including a catalyst of the formula: where X is a halide, such as iodide, bromide or preferably chloride, and each of R and R is independently H, Q-Ce alkyl or Q-C6 alkoxy, provided at least one of R19 or R20 is not H. Moreover, each phenyl group may contain more than one R19 or R20 groups. Furthermore, one or both of the phenyl groups of the bisphenyl moiety may be replaced with other aromatic groups such as a naphthyl, pyridyl or other substituted aryl groups. One of the useful hydrogenation catalyst of the present invention is a product produced by contacting a ruthenium diacetate of the formula Ru(OAc)2((i?)-MeOBIPHEP) with a halide source, such as alkaline metal halides (e.g., LiX, NaX, KX and CsX, where X is a halide) or hydrohalides (e.g., HX, where X is a halide), preferably hydrochloric acid, where Ru(OAc)2((i?)-MeOBIPHEP) is a compound of the formula: Without being bound by any theory, it is believed that treating Ru(OAc)2((R)-MeOBIPHEP) with hydrochloric acid results in replacing both of the OAc groups with chloride; thus, the resulting product is believed to be Ru(Cl)2((£)-MeOBIPHEP). Interestingly, however, when Ru(OAc)2((R)-MeOBIPHEP) is treated with less than about 2 equiv. of HC1, the resulting hydrogenation catalyst does not produce (R)-3-hydroxy ester IXa in a high enantiomeric excess. Surprisingly and unexpectedly, in some cases such a hydrogenation catalyst produces (S)-3-hydroxy ester predominantly. However, when at least about 5 equiv. of HC1 is added to Ru(OAc)2((£)-MeOBIPHEP), preferably at least about 10 equiv. and more preferably at least about 20 equiv., the resulting hydrogenation catalyst enantioselectively reduces the P-ketoester XII to the corresponding (3i?)-3-hydroxy ester. The precursor of chiral hydrogenation catalyst of the present invention, i.e., ruthenium dicarboxylate diphosphine compound or [Ru(OC(=0)R')2(diphosphine)], can be prepared according the following reaction scheme: NaOAc/AcOH , [RuCl2(COD)]n + Diphosphine +- Ru(OC(=0)R')2(diphosphine) Toluene In this manner a variety of chiral ruthenium dicarboxylate diphosphine, including those listed in Example 16, can be prepared. The process for preparing a ruthenium dicarboxylate diphosphine compound generally involves contacting [RuCl2(COD)]n, which is commercially available or preferably prepared according to the procedure of Albers et al., Inorg. Synth.y 1989,26> 68, with a mixture of a carboxylate salt and the corresponding carboxylic acid, i.e., MOC(=0)R' and HOC(=0)R' mixture, such as sodium acetate/acetic acid and sodium pivalate/pivalic acid mixtures, in an aprotic organic solvent, preferably toluene. The mixture is heated at a temperature of about 80 °C to about 120 °C, preferably about 100 °C. A typical reaction time is from about 15 hours to about 72 hours, preferably from about 20 hours to about 48 hours. The amount of carboxylate salt used can be about 2 equiv. to about 50 equiv., preferably about 2 equiv. to about 25 equiv., more preferably about 2.1 equiv. to about 10 equiv., and most preferably about 2.5 equiv. Preferably a small excess of [RuCl2(COD)]n is used relative to the diphosphine compound to ensure complete conversion of the diphosphine compound. While commercially available [RuCl2(COD)]n complex can be used, it has been found that freshly prepared [RuCl2(COD)]n complex from ruthenium trichloride generally affords shorter reaction time, more consistant and/or higher yield of ruthenium dicarboxylate diphosphine compound. In this manner, a one-pot synthesis of ruthenium dicarboxylate diphosphine compound can be achieved from inexpensive and readily available ruthenium trichloride. The P-hydroxy compound (e.g., (3i?)-3-hydroxy compound) IXa can be further purified, i.e., enantiomerically enriched, by recrystallizing the initial product to afford a product having at least about 99 %ee. Therefore, it should be appreciated that depending on the cost of a particular chiral hydrogenation catalyst, it maybe more economical to use a chiral hydrogenation catalyst which provides less than about 95 %ee of the p -hydroxy compound IXa, which can be further enantiomerically enriched by recrystallization. Unlike currently used ruthenium-based hydrogenation catalysts for asymmetric reduction of methyl 3-oxotetradecano-ate, the hydrogenation catalyst of the present invention does not require high purity conditions, e.g., hydrogen gas having purity of at least about 99.99%, to produce methyl 3-hydroxytetradecanoate in high yield and high enantiomeric excess. In fact, the asymmetric hydrogenation of methyl 3-oxotetradecanoate under technical grade conditions, e.g., hydrogen gas having purity of about 99.5% and nitrogen gas having purity of about 99.5%, using the hydrogenation catalyst of the present invention proceeds with a substantially similar rate as those / requiring high purity reaction conditions. Moreover, the hydrogenation catalyst of the present invention allows the use of lower hydrogen gas pressure, thereby reducing the cost of initial capital investments and reducing the danger associated with high hydrogen gas reaction conditions. In addition, by using asymmetric hydrogenation processes described above, the present invention allows asymmetric synthesis of the 5-lactone VII without a need for resolving any racemic intermediates. Typically, hydrogenation of P-ketoester XII, e.g., methyl 3-oxotetradecanoate, is conducted in a conventional hydrogenation solvent including an alkyl alcohol, such as ethanol or preferably in methanol, at a reaction temperature of about 80 °C. The concentration of the substrate (i.e., P-ketoester XII) in hydrogenation reaction is generally at about 40 wt%, and the ratio of HC1 to Ru(OAc)2((i?)-MeOBIPHEP) in the hydrogenation catalyst is about 20:1. A typical ratio of methyl 3-oxotetradecanoate to the hydrogenation catalyst is about 50,000:1. To this reaction mixture, typically about 40 bar of technical grade hydrogen gas is added, and the reaction is allowed to proceed for about 4 hours (h). The resulting methyl (£)-3-hydroxy tetradecanoate is then saponified by diluting the crude hydrogenation solution in methanol and 28% aqueous sodium hydroxide solution at room temperature. The saponified product is then acidified with an acid, such as sulfuric acid, to isolate (i?)-3-hydroxy tetradecanoic acid. In this manner, the P-hydroxy acid III, such as(£)-3-hydroxy tetradecanoic acid, can be produced in at least about 90% isolated yield from the corresponding P-ketoester XII, more preferably in at least about 93% isolated yield and most preferably in at least about 95% isolated yield. The enantiomeric excess of the product is at least about 90%ee, preferably at least about 95%ee, and more preferably at least about 99%ee. The enantiomeric excess can be increased to at least about 95%ee after a single recrystallization, preferably at least about 99%ee, and most preferably at least about 99.5%ee. The P-ketoester XII can be readily prepared by a variety of known methods. See for example, Case-Green, Synlett> 1991, 781-782 and U.S. Patent No. 5,945,559, issued to Sotoguchi et al., which are incorporated by reference herein in their entirety. The 8-lactone VII can also be prepared by treating a 2-alkyl-acetoacetate ester of the formula: XIII with acyl halide Ila and contacting the resulting product with a base or preferably an acid, such as ones described above, under conditions sufficient to produce the 8-lactone VII, wherein R and R are those described above. Without being bound by any theory, it is believed that a reaction between the 2-alkyl-acetoacetate ester XIII and the acyl halide Ila produces a-acetyl-p-ketoester of the formula: as the initial product, where R , R and R~ are those described above and R is Ci-Qo alkyl. Solvolysis, e.g., methanolysis (i.e., contacting with methanol), in basic or preferably acidic conditions, of a-acetyl-P-ketoester XIV removes the acyl group to produce the 8-hydroxy-P-ketoester VIII, where R is R", which can then be used to produce the 8-lactone VII as described above. Preparation of P-ketoesters from methyl acetoacetate is disclosed in Japanese Patent No. 10-53561, issued to Sotokuchi et al., which is incorporated by reference herein in its entirety. The 2-alkyl-acetoacetate ester XIII can be prepared by forming an enolate of acetoacetate ester by contacting the acetoacetate ester with a base, such as calcium oxide or calcium hydroxide, in typically refluxing toluene followed by reacting the enolate with the acyl halide III. Alternatively, the 8-hydroxy-P-ketoester Via (where R is Ci-Qo alkyl, preferably hexyl), and hence ultimately the 8-lactone VII, can be produced by reacting acetoacetate ester (compound XIII, where R2 is H) with acyl chloride Ila as described above to initially produce the 8-hydroxy-p-ketoester Via (where R is H). The 8-hydroxy-P-ketoester VIII, where R2 is H, can be deprotonated with a base to produce a second enolate which can be reacted with an alkyl group containing a leaving group, such as those described above, e.g., hexyl bromide, to produce the S-hydroxy-p-ketoester Via (where R is Q-Qo alkyl, e.g., hexyl). In generating the second enolate, a reverse addition, i.e., addition of the 8-hydroxy-P-ketoester Via (where R is H) to a solution containing a base, can be used, for example, to reduce the amount of elimination product which may result in the conventional addition step, i.e., addition of a base to a solution of the 8-hydroxy-p-ketoester VIII. Additional objects, advantages, and novel features of this invention will become apparent to those skilled in the art upon examination of the following examples thereof, which are not intended to be limiting. EXAMPLES Example 1 This example illustrates a method for preparing 1-methoxy-l-trimethylsiloxy-l-octene. A 1000-mL, 3-necked flask was fitted with Claisen adapter with septum/thermocouple and nitrogen adapter, paddle stirrer, and 250-mL pressure-equilibrating addition funnel. The flask was sealed and the atmosphere changed to dry nitrogen (10 nitrogen-vacuum cycles). Dry THF (100 mL) and 69.9 mL (50.5 g, 499 mmol, 1.05 equiv) of diisopropylamine were added via syringe. The solution was cooled to -10 °C, and 190 mL of 2.5 M butyllithium in hexane (475 mmol) was added dropwise via syringe over 28 min at 0 to -5 °C. The addition funnel was rinsed with 10 mL of dry hexane. The resulting solution was stirred at 0 to -5 °C for 30 min then cooled to -78 °C. Methyl octanoate (85.7 mL, 75.16 g, 475 mmol) was added via syringe to the addition funnel then added dropwise to the reaction mixture at -75 °C to -78 °C over 70 min. The resulting mixture was stirred at -78 °C for 30 min. The addition funnel is rinsed with 10 mL dry hexane. Chlorotrimethylsilane (TMSC1) (72 mL, 61.9 g, 570 mmol, 1.2 equiv) was added via syringe to the addition funnel then added dropwise to the reaction mixture at - 75 °C to -78 °C over 50 min. The addition funnel was rinsed with 10 mL dry hexane. The suspension was stirred at -75 °C to -78 °C for 30 min and then allowed to warm to 25 °C over 60 min and stir for 30 min. The reaction mixture was concentrated on a rotary evaporator at 25-30 °C and 40-100 mm Hg. The residue was diluted with 200 mL dry heptane then suction filtered under nitrogen (using a Teflon cannula and 60-mL airlessware funnel with medium frit). The flask, funnel and solids were rinsed with 100 mL of dry heptane. The combined mother liquors were concentrated on a rotary evaporator at 25-30 °C and 10-90 mm Hg to afford 119.2 g of pale yellow oil. The oil was distilled using a short-path apparatus at 1.0-1.2 mm Hg (b.p. 82-84 °C) to afford 99.86 g of clear colorless liquid. Example 2 This example illustrates a method for preparing (J?)-3-hydroxytetradecanoic acid. A solution of 33.67 g (600 mmol) potassium hydroxide in 600 mL of H20 was added dropwise at 0-5 °C to a solution of 60.00 g (232.8 mmol) of the methyl (i?)-3-tiydroxytetradecanoate in 1200 mL of ethanol over 80 min. The resulting suspension was stirred at 0 °C for 3 h. Hydrochloric acid (1 N, 600 mL, 600 mmol) was then added dropwise at 0-5 °C over 50 min. The resulting suspension was stirred at 0 °C for 15 min. The precipitate was suction filtered, slurry-washed with 600 mL of ft^O, then air dried at 25 °C for 64 h to afford 52.76 g of colorless solid. The solid was recrystallized from 400 mL of ethyl ether (hot filter and cooled to -28 °C) to afford 49.87 g (87.9%) of colorless solid after 2 h of air drying and 2 h of drying in vacuo at 25 °C. Example 3 This example illustrates a method for preparing trimethyl-silyl (R)-3-(trimethylsiloxy)tetradecanoate. A 1000-mL, 3-necked flask was fitted with Claisen adapter with septum/thermocouple and nitrogen adapter, paddle stirrer, and 50-mL pressure-equilibrating addition funnel with septum. The flask was charged with 45.00 g (184.1 mmol) of (i?)-3-hydroxytetradecanoic acid and DMAP (113 mg, 0.921 mmol, 0.5 mol%). The reactor was sealed, nitrogen started, then 200 mL of dry THF and 30.8 mL (30.12 g, 380.8 mmol) of dry pyridine were added via syringe. Stirring (200 rpm) was started and the flask was immersed in a cool water bath. The addition funnel was charged with 49.0 mL (41.91 g, 385.8 mmol) of TMSC1. The TMSC1 was then added dropwise at 20-25 °C over 30 min. The addition funnel was rinsed with 5 mL of dry THF. The suspension was stirred at 20-25 °C for 20 h then used directly in the next step. 300 MHz lU NMR (CDC13) 5 0.11 (s, 9H), 0.27 (s, 9H), 0.87 (t, 3H), 1.22-1.37 (m, 18H), 1.42-1.49 (m, 2H), 2.41-2.44 (d, 2H), 4.08 (m, 1H). NMR analysis of another run indicated complete conversion in 2 h and no change at 20 h. Example 4 This example illustrates a method for preparing (£)-3-(trimethylsiloxy)tetradecanoyl chloride. The suspension of trimethylsilyl (i?)-3-(trimethylsiloxy)-tetradecanoate was cooled to 0 °C and 0.14 mL (135 mg, 1.84 mmol, 1.0 mol%) of dry DMF was added via syringe. The addition funnel was charged with thionyl chloride (17.5 mL, 28.5 g, 240 mmol, 1.3 equiv) which was then added dropwise at 0 to -5 °C over 11 min. The resulting suspension was stirred at -2 to -3 °C for 7 h. Concentration of the reaction mixture at 0 °C and 30 mm Hg on a rotary evaporator (dry ice-methanol condenser) resulted in recovery of a THF/TMSC1 mixture (163 mL colorless liquid). The residue was diluted with 150 mL of dry hexane at 0 °C. The suspension was filtered under dry nitrogen (Teflon cannula and 200-mL airlessware funnel). The flask and solids were rinsed with 100 mL of dry hexane at 0 °C. The combined mother liquors were concentrated at 0 °C and 30 mm Hg on a rotary evaporator (dry ice-methanol condenser) (254 mL colorless liquid with some solids). The residual oil was used directly in the next step. 300 MHz lH NMR (CDC13) 5 0.12 (s, 9H), 0.88 (t, 3H), 1.22-1.37 (m 18H), 1.42-1.52 (m, 2H), 2.95 (d, 2H), 4.18 (m, 1H). Example 5 This example illustrates a method for preparing methyl (i?)-3,5-bis-(Trimethylsiloxy)-2-hexyl-3-hexadecenoate. A 1000-mL flask was fitted with Claisen adapter with septum/thermocouple and nitrogen adapter, paddle stirrer, and a 50-mL pressure-equilibrating addition funnel. The flask was sealed and nitrogen flow and stirring (200 rpm) were started. The crude CR)-3-(trimethylsiloxy)tetradecanoyl chloride of Example 4 was slowly diluted with 150 mL of dry THF at 0 to -5 °C. Distilled 1-methoxy-l-trimethylsiloxy-l-octene (50.2 mL, 42.42 g, -184 mmol) from Example 1 was added via syringe. The addition funnel was charged with 25.7 mL (18.63 g, 184.1 mmol) of triethylamine. The amine was then added dropwise at- 10 to 0 °C over 20 min. The addition funnel was rinsed with 5 mL of dry THF. The resulting suspension was stirred at -5 °C for 16 h. The suspension was concentrated on a rotary evaporator at 25-30 °C and 30-80 mm Hg (150 mL of colorless liquid with some solid). The residue was diluted with 200 mL of dry hexane and the suspension stirred briefly at 25 °C. The suspension was suction filtered through 10 g of celite under dry nitrogen (Teflon cannula and 200-mL airlessware funnel). The flask and cake were rinsed with 100 mL of dry hexane. The mother liquors were concentrated on a rotary evaporator at 25-30 °C and 30-80 mm Hg to afford 94.78 g of slightly cloudy orange oil, which was used directly in the next step. ' Methyl (i?)-3,5-bis-(Trimethylsiloxy)-2-hexyl-3-hexadecenoate: 300 MHz lH NMR (CDC13) 5 0.08 (d, 9H), 0.19 (d, 9H), 0.87 (m, 6H), 1.28-1.58 (m, 30H), 2.86-2.91 (m, 1H), 3.75 (d, 3H), 4.33-4.42 (m, 1H), 4.65 (t, 1H). Methyl (3i?)-2-hexyl-5-oxo-3-(trimethylsiloxy)hexadecanoate: 300 MHz {H NMR (CDC13) 5 0.06 (d, 9H), 0.81-0.89 (m, 6H), 1.16-1.46 (m, 28H), 1.74-1.86 (m, 2H), 2.46-2.76 (m, 2H), 3.38-3.46 (m, 1H), 3.69 (m, 3H), 4.09-4.19 (broad m, 1H). NMR analysis of another run indicated complete conversion in about 2 h and no significant change after 16 h. Example 6 This example illustrates a method for preparing (£)-3-hexyl-4-hydroxy-6-undecyl-5,6-dihydropyran-2-one. A 1000-mL flask was fitted with septum/thermocouple, paddle stirrer, and a nitrogen adapter. The flask was sealed and nitrogen flow and stirring (200 rpm) started. The crude methyl (i?)-3,5-bis-(trimethylsiloxy)-2-hexyl-3-hexadecenoate of Example 5 was cooled to 0 °C and anhydrous potassium carbonate powder (38.16 g, 276 mmol) and 350 mL of cold methanol were added at 0 to 5 °C. The suspension was stirred at 0 °C for 17 h. Hydrochloric acid (46 mL of 12 N) was added dropwise at 0 to 5 °C over 43 min. The suspension was diluted with 150 mL of methanol then stirred at 0 °C for 4 h. The precipitate was suction filtered (mother liquors are recycled to complete the transfer), washed with 100 mL of 0 °C methanol, washed with three times with 100 mL of H20, then air dried at 25 °C for 17 h to afford 76.90 g of colorless solid. The solid (72.09 g) was re-slurried in 700 mL of H20 at 25 °C. After stirring for about 2 h, the solid was suction filtered, washed with 200 mL of H20, and air dried at 25 °C for 70 h to afford 41.30 g of colorless solid. The methanol liquors were combined and concentrated on a rotary evaporator at 35-40 °C and 60-90 mm Hg. The resulting residue was dried in vacuo at 25 °C and NMR analysis of another run indicated complete conversion in 5-6 h at 0 °C. Theoretical Yield = 64.50 g based on (i?)-3-hydroxytetradecanoic acid. Example 7 This example illustrates a method for preparing trimethyl-silyl (R)-3-(trimethylsiloxy)tetradecanoate using HMDS. A 1000-mL, 3-necked flask was fitted with condenser/nitrogen adapter, paddle stirrer, and 250-mL pressure-equilibrating addition funnel/septum. The reactor was charged with 45.00 g (184.1 mmol) of (.R)-3-hydroxytetradecanoic acid from Example 2. The flask was sealed, nitrogen was started, 290 mL of dry THF was added via cannula, and stirring (200 rpm) was started. The addition funnel was charged with 38.9 mL (29.72 g, 184.1 mmol) of hexamethyldisilazane (HMDS). The HMDS was then added dropwise at 20-25 °C over 15 min. The addition funnel was rinsed with 10 mL of dry THF after the HMDS addition was completed. The suspension was heated to reflux (oil bath at 75 °C) over 4 min then refluxed for 2 h. The suspension was cooled to 25 °C then filtered under dry nitrogen (Teflon cannula and 60-mL airlessware funnel with medium frit). The flask and trace solids were washed with 50 mL of dry THF. The combined mother liquors were concentrated by distillation at atmospheric pressure (oil bath at 85 °C) (about 200 mL of THF collected). The pot solution (188.1 g of clear pale green liquid) can be used directly in the next step. Example 8 This example illustrates a method for preparing diethyl 2-hexylmalonate. A 5-L, 3-necked Morton flask with 2-L paddle stirrer was charged with sodium ethoxide (21 wt% in EtOH, 1000 mL, 2.801 moles) and 500 mL of absolute ethanol. Diethyl malonate (425 mL, 2.80 mol) in 50 mL of ethanol was added dropwise via a * 500-mL pressure-equalized dropping funnel over 45 min at room temperature with stirring (150 rpm). Additional ethanol (250 mL) was added during the addition to redissolve precipitated salts. The funnel was washed with 150 mL of ethanol. The reaction mixture was heated to reflux and 1-bromohexane (432 mL (3.08 mol, 1.1 equiv) was added dropwise over 40 min. The funnel was washed with 50 mL of ethanol (total ethanol added about 1 L), and the reaction held at reflux for 2 h, after which the reaction mixture was neutral to moist litmus. The heat was removed and the reaction allowed to slowly cool to room temperature overnight. The reaction was then reheated to reflux and 1200 mL of ethanol distilled from the reaction mixture. Water (1 L) and heptane (500 mL) were added, the mixture transferred to a 4-L separatory funnel, and the layers separated. The organic layer was washed with 500 mL of saturated brine, dried with MgSC>4, and the solvent removed under reduced pressure. Crude product analysis (GC): 1-bromohexane (TR = 3.4 min, 4.3%); diethyl malonate (TR = 4.7 min, 2.9%); diethyl 2-hexylmalonate (TR = 10.7 min, 83.1%); diethyl 2,2-dihexylmalonate (TR = 14.9 min, 9.2%). The crude product was transferred to a 1-L round-bottomed flask and a short-path distillation head connected. The crude mixture was gradually heated under 0.7 to 1.0 mm Hg of pressure to first distill off a fraction containing mostly 1-bromohexane (38-50 °C) followed by a second fraction (101 g, bp = 55-100 °C at 0.95 mm Hg) which contained approximately 2% 1-bromohexane, 10% diethyl malonate, 87% diethyl 2-hexylmalonate, and 0.8% diethyl 2,2-dihexylmalonate (determined by GC). The main cut (459 g, bp = 102-106 °C at 0.95 torr) contained no 1-bromohexane, 0.4% diethyl malonate, 96.7% diethyl 2-hexylmalonate, and 2.7% diethyl 2,2-dihexylmalonate. The pot bottoms contained 52 g material, which contained 22% diethyl 2-hexylmalonate and 77% diethyl 2,2-dihexylmalonate (by GC). Yield of diethyl 2-hexylmalonate in main fraction: 443.6 g (1.816 mol, 65%). Example 9 This example illustrates a method for preparing dimethyl 2-hexylmalonate. A 2-L, 3-necked Morton flask with 1-L paddle stirrer was charged with sodium methoxide (25 wt% solution in methanol, 460 mL, 2.01 mol) and 400 mL of HPLC grade methanol. A solution of dimethyl malonate (216 mL, 250 g, 1.89 mol) in 90 mL of methanol was added dropwise via a 500-mL pressure-equalizing dropping funnel over 45 min with stirring (175 rpm). The reaction mixture became thick during addition due to precipitation; 110 mL of additional methanol was added to maintain efficient stirring (stirring rate increased to 350 rpm). The reaction mixture was then heated to reflux and 1-bromohexane (296 mL, 348 g, 2.11 mol) was added dropwise over 60 min. The funnel was washed with 50 mL of methanol, and the reaction mixture allowed to reflux overnight. A short-path distillation head was attached, and 800 mL of methanol distilled from the reaction mixture. The reaction was then diluted with 300 mL of H2O and 700 mL of heptane, and stirred for 15 min. The mixture was transferred to a 4-L separatory funnel and the layers separated. The organic phase was washed with 300 mL of saturated brine, dried (MgS04), and concentrated under reduced pressure to give 399.5 g (98%) of crude product. Crude product analysis (GC): dimethyl malonate (TR = 4.5 min, 0.78%); 1-bromohexane (TR = 4.7 min, 1.0%); dimethyl 2-hexylmalonate (TR = 10.0 min, 84.5%); dimethyl 2,2-dihexylmalonate (TR = 13.2 min, 10.0%). The crude product was transferred to a 1-L round bottomed flask connected to an 8" fractionating column and short-path distillation head. The crude mixture was slowly heated to 100 °C under 0.6 mm Hg of pressure to distill off a low-boiling forerun fraction containing solvent, 1-bromohexane, and dimethyl malonate. The bath was heated to 105 °C and an approximate 25 mL fraction was collected (b.p. 85-86 °C, 0.62 mm Hg) followed by the main cut (b.p. 86-89 °C, 0.66 mm Hg). The first fraction contained no 1-bromohexane or dimethyl malonate, 99.6% dimethyl 2-hexylmalonate, and 0.4% dimethyl 2,2-dihexylmalonate. The main cut (277.1 g) contained no 1-bromohexane or dimethyl malonate, 98.8% dimethyl 2-hexylmalonate, and 1.2% dimethyl 2,2-dihexylmalonate. The pot bottoms (59 g) contained 43% dimethyl 2-hexylmalonate and 56% dimethyl 2,2-dihexylmalonate (GC). Yield of dimethyl 2-hexylmalonate in first two fractions: 295.1 g (1.365 mol, 72%). Example 10 This example illustrates a method for preparing 2-(ethoxycarbonyl)octanoic acid, i.e., ethyl hexylmalonate half-acid. To a solution of diethyl 2-hexylmalonate of Example 8 (244.36 g, 1.000 mol) in 25 mL of absolute ethanol in a 2-L, 3-necked Morton flask was added a solution of potassium hydroxide (59.9 g, 0.907 mol)(weight adjusted for 85% assay of commercial potassium hydroxide) in 450 mL of absolute ethanol dropwise via a 500-mL pressure-equalizing dropping funnel over 75 min. The funnel was washed with 25 mL of absolute ethanol. The reaction mixture was stirred for 2 h, and 300 mL of ethanol was then removed under reduced pressure. Water (500 mL) was added, and the mixture extracted with 500 mL of heptane to remove unreacted diethyl 2-hexylmalonate. The aqueous solution was acidified with 12 M HC1 to pH 2 then extracted with 500 mL of heptane. The heptane solution was dried (MgSOJ and the solvent removed under reduced pressure to give 2-(ethoxycarbonyl)octanoic acid as a colorless oil. Traces of ethanol were removed by adding 20 mL of toluene to the crude product, followed by stripping of the solvent at 1 mm Hg of pressure with stirring. The yield was 190.9 g (0.8827 mol, 88.3% based on diethyl 2-hexylmalonate, 97% based on potassium hydroxide). Example 11 This example illustrates a method for preparing 2-(methoxycarbonyl)octanoic acid, i.e., methyl hexylmalonate half-acid. A solution of dimethyl 2-hexylmalonate of Example 9 (220.35 g, 1.019 mol) in 500 mL of methanol was prepared in a 2-L round-bottomed flask with magnetic stirring. A solution of potassium hydroxide (60.8 g, 0.921 mol) in 500 mL of methanol was added dropwise at 20-25 °C (H2O bath) over 60 min with stirring. The reaction was stirred for 2 h then 950 mL of methanol was removed under reduced pressure on a rotary evaporator. AIL mixture of 1:1 H2O and heptane was added, and the layers separated in a 2-L separatory funnel. The aqueous layer was acidified with 12 M HC1 to pH 1. The suspension was then extracted with 500 mL of heptane and the heptane solution dried (MgSC^) and concentrated to give a cloudy oil (suspended salts). Toluene (200 mL) was added, and the mixture was allowed to stand for 21 h. The suspension was filtered and the solvent evaporated under reduced pressure to give 182.53 g of 2-(methoxycarbonyl)octanoic acid as a clear oil (0.902 mol, 88.5% based on dimethyl 2-hexylmalonate, 98% based on potassium hydroxide). Example 12 This example illustrates a method for preparing 3-(trimethylsiloxy)tetradecanoyl chloride. A 500-mL, 3-necked Morton flask was charged with (-R)-3-hydroxytetradecanofc acid of Example 2 (20.06 g, 82.09 mmol) and 90 mL of dry THF under N2 with magnetic stirring. Hexamethyl-disilazane (HMDS, 17.3 mL, 82.0 mmol, 1.00 equiv) was added via syringe, and the reaction mixture heated to reflux for 2 h then allowed to cool to 20-25 °C. The reaction was checked by !H NMR, which showed clean conversion to trimethylsilyl (i?)-3-(trimethylsiloxy)tetradecanoate. The reaction was cooled to 0 °C while monitoring the internal temperature then pyridine (0.34 mL, 4.2 mmol, 5 mol%) was added via syringe followed by thionyl chloride (6.6 mL, 90.5 mmol, 1.1 equiv), which was added over 6 min. The reaction was stirred at 0 °C for 140 min, and checked by lH NMR, which showed about 3% trimethylsilyl (i?)-3-(trimethylsiloxy)tetradecanoate and a small amount of a degradation product. Dry heptane (90 mL) was added, and the reaction stirred for 30 min and filtered under dry nitrogen (Teflon cannula and 200-mL coarse-fritted airlessware funnel) into a dry 1-L, 3-necked, round-bottomed flask. The flask and funnel were washed with 50 mL of heptane. The solvent was evaporated under gradually increasing vacuum (50 to 8 mm Hg using a Vacuubrand™ vacuum pump) at 0 °C over 2 h to give 3-(trimethylsiloxy)-tetradecanoyl chloride as a yellow oil, which was used directly in the next step. Example 13 This example illustrates a method for preparing ethyl 5-hydroxy-2-hexyl-3-oxohexadecanoate. A 1-L, 3-necked Morton flask fitted with a mechanical stirrer (500 mL-paddle) was charged with 2-(ethoxycarbonyl)-octanoic acid from Example 10 (21.34 g, 98.67 mmol) and 150 mL of dry THF. Triethylamine (28.0 mL, 201 mmol, 2.04 equiv) was added followed by magnesium chloride (Aldrich; water content temperature then cooled to 0 °C. A racemic mixture of 3-(trimethylsiloxy)-tetradecanoyl chloride (82.1 mmol, 0.83 equiv) in about 30 mL of heptane was added dropwise over 15 min via a 50-mL pressure-equalizing addition funnel. The funnel was washed with 20 mL of THF (total THF = 170 mL), and the reaction was stirred for 15 h (150 rpm) while warming to rt. The reaction was then cooled to 0 °C, and 80 mL of 3 M HC1 (3 equiv) was added dropwise over 9 min followed immediately by 150 mL of heptane. The mixture was stirred for 15 min, and the layers separated. The organic layer was washed once with 100 mL of water and twice with 50 mL of saturated NaHC03. The organic layer was dried (MgSC^) and the solvent removed under reduced pressure to give 32.05 g. {H NMR analysis showed ethyl 5-hydroxy-2-hexyl-3-oxohexadecanoate as the major product. 300 MHz *H NMR (CDC13) 5 0.88 (m, 6H), 1.26 (m, 29H), 1.43 (m, 2H), 1.84 (m, 2H), 2.57, 2.71 (m, 2H), 2.88 (m, 1H), 3.42 (m, 1H), 4.04 (m, 1H), 4.19 (q, 2H). Example 14 This example illustrates the effect of reaction conditions on the yield of 3-hexyl-4-hydroxy-6-undecyl-5,6-dihydropyran-2-one from ethyl (5i?)-2-hexyl-5-hydroxy-3-oxohexadecanoate. Ethyl (5i?)-2-hexyl-5-hydroxy-3-oxohexadecanoate was subjected to a variety of reaction conditions to produce 3-hexyl-4-hydroxy-6-undecyl-5,6-dihydropyran-2-one. The results are shown in Table 1. Table 1. Cyclization of ethyl (5i?)-2-hexyl-5-hydroxy-3-oxohexa-decanoateto 3-hexyl-4-hydroxy-6-undecyl-5,6-dihydropyran-2-one. Example 15 This example illustrates a method for preparing 3-hexyl-4-hydroxy-6-undecyl-5,6-dihydropyran-2-one. A solution of crude racemic ethyl 5-hydroxy-2-hexyl-3-oxohexadecanoate of Example 13 (31.35 g, 78.64 mmol) was prepared in 125 mL methanol in a 1-L, 3-necked Morton flask with mechanical stirring. Hydrochloric acid (12 M, 6.6 mL, 81 mmol, 1.0 equiv) was added with stirring (150 rpm). After 1.5 h, 3-hexyl-4-hydroxy-6-undecyl-5,6-dihydropyran-2-one started to precipitate from the reaction mixture. After 26.5 h, the suspension was cooled to 0 °C and transferred to a 150-mL coarse-fritted funnel with 10 mL of cold methanol. The precipitate was filtered and washed twice with 15 mL of cold methanol to give 3-hexyl-4-hydroxy-6-undecyl-5,6-dihydropyran-2-one as a white crystalline solid (17.39 g, 49.3 mmol, 63% yield from 3-hydroxytetradecanoic acid). Example 16 This example also illustrates the effect of different phosphine ligands on the ruthenium hydrogenation catalyst on the yield and %ee of asymmetric hydrogenation of P-ketoester. The hydrogenation reaction of p-ketoester 1 of Example 21 was conducted using Ru(OAc)2(diphosphine)(S/C 50'000) with 20 equivalents of HC1 at 60 °C, under H2 (70 bar) in methanol, with concentration of p-ketoester 1 at 30 %wt. The identity of diphosphine ligand, % isolated yield and (%ee) are shown below: Example 19 This example illustrates a method for producing (6£)-3-hexyl-5,6-dihydro-4-hydroxy-6-undecyl-pyran-2-one using tert-butylmagnesium chloride. In a 500 mL 3-necked round bottom flask fitted with a Claisen head with N2 inlet, a West condenser, a thermocouple-J-KEM controller and an addition funnel was added a solution of tert-butylmagnesium chloride (341 mL of a 1.0 M solution, 341 mmole, 3 equiv.) at about 60 °C. Methyl-(i?)-3-(2'-bromo-r-oxooctyloxy)tetradecanoate (52.6.0 g, 113.5 mmole, 1 equiv.) and 25 mL of dry THF were added to an addition funnel. The starting bromodiester mixture was slowly added to the t-BuMgCl/THF mixture at reflux over about one hour. The reaction mixture was sampled at 1 and 2 hours at about 60 °C (resulting in 90 and 91% area normalized gas chromatography (AN GC) analysis, respectively). After 2 hours the resulting reaction mixture was cooled and concentrated on a roto-evaporator to about 1/3 to about 1/2 the original volume. The resulting syrupy mixture was taken up in about 250 mL of toluene and added to a mixture containing 250 mL of toluene, 75 mL of 10% HC1 in a 1 L jacketed flask keeping the quenched solution below 30 °C. The aqueous layer was removed. The organic layer washed one time with 50 mL of 1.0 N HC1 solution. The aqueous layer was removed, the organic layer washed one time with 50 mL of water, dried over magnesium sulfate, filtered and concentrated. This resulted in a gel-like solid residue. The residue was dissolved in 250 mL of ethyl acetate at 40 °C. The ethyl acetate was removed on the roto-evaporator. The resulting crude off-white solid (42.4 g) was slurried up in about 100 mL of hexane and cooled to 0 °C, filtered and rinsed with 50 mL of cold hexane followed by another 25 mL of cold hexane. The isolated white solids were air dried under vacuum for about 1 to 2 hours resulting in 31.4 g of (6i?)-3-hexyl-5,6-dihydro-4-hydroxy-6-undecyl-pyran-2-one (78.4% yield). Example 20 This example illustrates a method for producing (6i?)-3-hexyl-5,6-dihydro-4-hydroxy-6-undecyl-pyran-2-one using terf-amylmagnesium chloride. In a 500 mL 3-necked round bottom flask fitted with a Claisen head with N2 inlet, a West condenser, a thermocouple-J-KEM controller and an addition funnel, a solution of tert-amylmagnesium chloride (341 mL of a 1.0 M solution in Et20, 341 mmole, 3 equiv.) was added. The Et20 was replaced with THF and heated to about 60 °C. Methyi-(R)-3- (2'-bromo-r-oxooctyloxy)-tetradecanoate (52.6.0 g, 113.5 mmole, 1 equiv.) and 25 mL of dry THF was added to an addition funnel. The starting bromodiester mixture was slowly-added to the t-amylMgCl/THF mixture at reflux over about one hour. The reaction mixture was sampled at 1 and 2 hours at about 60 °C (resulting in 81 and 80% AN GC analysis, respectively). After about 2 hours the resulting reaction mixture was cooled and concentrated to about 1/3 to about 1/2 the original volume. The resulting syrupy mixture was diluted with about 250 mL of toluene and added to a stirred mixture containing about 250 mL of toluene and about 75 mL of 10% HC1 in a 1 L jacketed flask while maintaining the quenched solution below about 30 °C. The aqueous layer was removed. The organic layer was washed successively with about 50 mL of 1.0 N HC1 solution and 50 mL of water, dried over magnesium sulfate, filtered and concentrated to yield a solid residue. The residue was dissolved in about 400 mL of ethyl acetate at about 40 °C. The ethyl acetate was removed on the roto-evaporator. The resulting crude off-white solid (42.3 g) was slurried up in about 100 mL of hexane and cooled to about 0 °C> filtered and rinsed with about 50 mL of cold hexane followed by another about 35 mL of cold hexane. The isolated white solids were air dried under vacuum for about 1 to 2 hours resulting in 27.6 g of (6i?)-3-hexyl-5,6-dihydro-4-hydroxy-6-undecyl-pyran-2-one (69.1% yield). Example 21 This example illustrates a process for producing p-ketoester 1 of Example 17. Into a 250 mL three necked round bottomed flask equipped with a mechanical stirrer and reflux condenser under nitrogen was added 1.54 g of magnesium powder (99.5% pure, 50 mesh) and methanol (about 50 mL). The resulting mixture was heated to reflux overnight. The reflux condenser was replaced with a distillation head. Toluene (about 150 mL) was added and methanol was removed by azeotropic distillation until a head temperature of 104 °C was reached. Approximately 82 mL of distillate was collected. To the resulting reaction mixture was added 29 g of methyl acetoacetate at 45 °C. Methanol generated from the reaction was removed by distillation until a head temperature of about 104 °C was reached. Approximately 62 mL of distillate was collected. The reaction mixture was cooled to room temperature. The resulting mixture was then heated to about 60 °C and lauroyl chloride (20.71 g) in 20 mL of toluene was added over 2 hours, maintaining the reaction mixture at about 60 °C. The resulting mixture was stirred for another 60 minutes. GC analysis showed that less than 1 % lauroyl chloride remained. Methanol (14.4 mL) was added and the resulting mixture was heated to about 70 °C and stirred for 4 hours. Another 9.0 mL of methanol was added and the resulting mixture was heated to 75 °C for an additional 20 hours. The resulting mixture was cooled to room temperature and the reaction was quenched by the addition of concentrated HC1 (19.43 g) maintaining the temperature of the mixture below 35 °C. The lower aqueous phase was separated, and the toluene phase was washed with water (2 X 45 mL), aqueous potassium bicarbonate (0.75 g in 36 mL of water), and then washed with water (36 mL). Toluene was removed under a rotoevaporator (75 °C at about 25-30 mmHg) to afford D-ketoester 1 of Example 17 in 86.6 % yield (21.03 g, 92 % A.N. by GC). Example 22 This example illustrates a process for producing Ru(OAc)2((i?,)-MeOBIPHEP) (Di(r| -acetato)[(i?j-6,6>-dimethoxybiphenyl-2,2,-diyl)bis(diphenylphosphine)]-ruthenium(II). Into a 2 liter 2-necked round bottomed flask equipped with a thermometer, a Claisen head, a reflux condenser topped with an argon inlet and a Teflon-coated magnetic stirring bar was purged 3 times with vacuum and argon gas, was charged ruthenium (III) chloride hydrate (Ru content at 43.48 %> Johnson Matthey & Brandenberger AG, 42.0 g, 0.179 mol). The flask is then vacuum purged with argon 3 times. Ethanol (420 mL) and ci$,cis-1,5-cyclooctadiene (44 mL, 358 mmol) were added and the dark suspension was stirred at reflux for 24 h at a external heating bath temperature of 100 °C. After this period, the resulting brown suspension was cooled to room temperature and allowed to settle for 30 min, and the slightly yellow supernatant was removed with suction with a micro-filter candle (P4-porosity). The brown residue was stirred with ethanol (500 mL) for 10 min and allowed to settle for 30 min. The slightly yellow supernatant was removed with suction as above. In order to remove most residual ethanol and cyclooctadiene, the solid residue consisting of [RuCl2(COD)]n was taken up in toluene (500 mL) and rotary evaporated to dryness (55 °C at 50 mbar). The apparatus was then charged under argon with (-R)-(6,6>-dimethoxybiphenyl-2,2,-diyl)bis(diphenylphosphine) ((£)-MeOBIPHEP) (99.4 g, 171 mmol) and sodium acetate (70 g, 853 mmol) and purged with argon as above. After the addition of toluene/acetic acid (1:1 v/v, 1.0 L), the brown reaction mixture was stirred at a 100 °C bath for 22 h. After removal of volatiles by rotoevaporator (58 °C at 30 mbar) the residue was dried in vacuo (1 mbar) for 1 h at 50 °C and overnight at room temperature. The resulting brown residue was taken up in toluene (500 mL), the suspension was stirred for 15 min at room temperature and filtered with argon protection on a high porosity glass sintered filter covered with a 2 cm pad of pressed filter aid. The filter cake was rinsed five times with 100 mL toluene (total of 500 mL), the filtrates collected and rotary evaporated to dryness (60 °C at 30 mbar). After having been dried under vacuum (1 mbar) overnight at room temperature, the brown residue was treated under stirring with methanol (500 mL). The thick suspension was stirred for 1 h at 50 °C, for 1 h at room temperature and finally for 1 h in an ice/methanol bath. After removing the solvent with a micro-filter candle (P4-porosity), the residue was stirred with methanol (3 X 120 mL) in the ice/methanol bath, and the solvent was removed as described above. The yellow residue was dried in vacuo (1 mbar) overnight at room temperature and then dissolved at 50 °C under stirring in toluene (150 mL). Pentane (600 mL) was added dropwise to the resulting brown solution under stirring over 2 h at a temperature of 40-50 °C resulted in the formation of a yellow-brown suspension, which was stirred for 45 min at room temperature and for 1.5 h in an ice bath (ca. 2 °C). After removal of the supernatant by suction with a micro-filter candle (P4-porosity), the residue was stirred in pentane (500 mL) for 30 min at room temperature. Removal of the supernatant as above and drying in vacuo (1 mbar) overnight at room temperature afforded 117.0 g of the desired product as an adduct with 0.7 toluene, as a yellow powder (86 % yield, 93 % purity). Example 23 This example illustrates a synthetic process for producing [Ru(OAc)2((S)-BINAP)]. Under an argon atmosphere, a 25-mL 2-necked round-bottomed flask equipped with a reflux condenser was charged with (S)-BINAP (0.50 g. 0.80 mmol), 0.25 g (0.84 mmol) of [RuCl2(COD)]n> sodium acetate (0.33 g, 4.0 mmol) and toluene/acetic acid 1:1 (5 mL). The brown reaction mixture was stirred in an oil bath at 100 °C for 25 h. Thereafter, the volatiles were removed by rotatory evaporation, the residue was diluted with dichloromethane (5 mL) and the resulting yellow-brown suspension was filtered through celite. The filter cake was washed with dichloromethane (9 mL) in three portions, and the combined filtrates were concentrated and dried under high vacuum overnight at room temperature (r.t.). The brown oil was diluted in ether/hexane 1:1 (4 mL) and stirred for 30 min at r.t. to give a solid precipitate. The supernatant was removed by suction with a micro-filter candle and the residue was washed with hexane (5 mL) at r.t. and dried overnight. The crude product was diluted in methanol (5 mL) and stirred for 1 h at 50 °C, 1 h at r.t. (formation of a precipitate), and finally 1 h at 0 °C. The supernatant was removed as above, the residue was washed with methanol (2 mL) at 0 °C and dried overnight under high vacuum at r.t. to give [Ru(OAc)2((S)-BINAP)] (0.48 g, 72% relative to (S)-BINAP) as a brown crystalline powder. Example 24 This example illustrates a synthetic process for producing [Ru(OAc)2((R)-BIPHEMP)]. Under an argon atmosphere a 50-mL 2-necked round-bottomed flask equipped with a reflux condenser was charged with (£)-BIPHEMP (2.01 g, 3.65 mmol), [RuCl2(COD)]n (1.13 g, 3.83 mmol), sodium acetate (1.5 g, 18.2 mmol) and toluene/acetic acid 1:1 (20 mL). The brown reaction mixture was stirred in an oil bath at 100 °C for 31 h. The volatiles were removed by rotatory evaporation, and the residue was diluted with dichlorormethane (20 mL) and the, resulting yellow-brown suspension was filtered through celite. The filter cake was washed with dichloromethane (12 mL) in three portions and the combined filtrates were concentrated, diluted with methanol (10 mL) and stirred for 1 h at 50 °C, 1 h at r.t. (formation of a precipitate), and finally 1 h at 0 °C. The supernatant was removed by suction with a micro-filter candle, the residue was washed with methanol (6 mL) at 0 °C and dried overnight under high vacuum at r.t. to give [Ru(OAc)2((R)-BIPHEMP)] (2.48 g, 88% relative to (K)-BIPHEMP) as a brown crystalline powder. Example 25 This example illustrates a synthetic process for producing [Ru(OAc)2((i?)-3,5-t-Bu-MeOBIPHEP)]. Under an argon atmosphere a 25-mL 2-necked round-bottomed flask equipped with a reflux condenser was charged with (J?)-3,5-tBu-MeOBIPHEP (0.50 g, 0.49 mmol), [RuCl2(COD)]n (0.14 g, 0.51 mmol), sodium acetate (0.20 g, 2.44 mmol) and toluene/acetic acid 1:1(5 mL). The brown reaction mixture was stirred in an oil bath at 100 °C for 26 h, and the volatiles were removed under high vacuum. The resulting residue was diluted with hexane (10 mL) and the resulting yellow-brown suspension was filtered through celite. The filter cake was washed with hexane (9 mL) in three portions and the combined filtrates were concentrated and dried overnight under high vacuum at r.t. yielding [Ru(OAc)2((i?)-3,5-t-Bu-MeOBIPHEP)] (0.62 g, 99% relative to (i?)-3,5-t- Bu-MeOBIPHEP) as a brown crystalline powder. , Example 26 This example illustrates a synthetic process for producing [Ru((CH3)3CCO2)2((i0-MeOBIPHEP)]. Under an argon atmosphere a 25-mL 2-necked round-bottomed flask equipped with a reflux condenser was charged with (£)-MeOBIPHEP (1.06 g, 1.82 mmol), [RuCl2(COD)]n (0.56 g. 2.00 mmol) and toluene (2 mL). To this mixture a solution obtained by dissolving sodium hydride (0.22 g, 9.1 mmol) in a mixture of toluene (3 mL) and pivalic acid (6.0 g, 59 mmol) was added and the resulting brown reaction mixture was stirred in an oil bath at 100°C for 72 h, cooled, diluted with pentane (15 mL), and filtered through celite. The filter cake was washed successively with pentane (15 mL) in three portions and dichloromethane (25 ml) in four portions, the combined CH2C12 filtrates were concentrated and the resulting residue was dried overnight under high vacuum at r.t. The crude product was treated with methanol (10 mL) under stirring for 1 h at 50 °C, 1 h at r.t., and finally 30 min at 0 °C. The supernatant was removed by suction with a micro-filter candle, the residue was washed with methanol (5 mL) at 0 °C and dried overnight under high vacuum at r.t. to give [Ru((CH3)3CC02)2((i?)-MeOBIPHEP)] (0.66 g, 41% relative to (i?)-MeOBIPHEP) as a brown crystalline give powder. The foregoing discussion of the invention has been presented for purposes of illustration and description. The foregoing is not intended to limit the invention to the form or forms disclosed herein. Although the description of the invention has included description of one or more embodiments and certain variations and modifications, other variations and modifications are within the scope of the invention, e.g., as maybe within the skill and knowledge of those in the art, after understanding the present disclosure. CLAIMS 1. A process for the preparation of a 5-lactone of the formula (I): said process comprising treating an acyl halide of the formula (II): with a) a ketene acetal of the formula (III): to produce a 8-hydroxy-protected-p-enol ether ester of the formula (IV): followed by removing at least one of the protecting groups R and R ; and contacting the product with an acid to produce said S-lactone, or b) with a malonate half acid of the formula (V): to produce a 5-hydroxy-p-ketoester of the formula (VI): followed by treating said 5-hydroxy-protected-P-enol ether ester with an acid to produce said 5-lactone, wherein in the above formulae R1 isCt-C2oalkyl; R" is H or C1-C10 alkyl; R~ is a hydroxy protecting group; IT and RD in formulae (III) and (IV) are independently C1-C6 alkyl, C5-C20 aryl, C6-C20 arylalkyl or -SiR8R9R10, wherein R8, R9, R10is independently C1-C6 alkyl or phenyl; R5 in formulae (V) and (VI) is C1-C6 alkyl, C5-C20 aryl, or C6-C2o arylalkyl; R5 is C1-C6 alkyl, C5-C20 aryl or C6-C2o arylalkyl; R6 is H or R4; R7 is H or R3, and X is a halide. 2. The process of claim 1, wherein R is undecyl. 3. The process of claim 1 or 2, wherein R" is hexyl. 4. The process according to any of claims 1 to 3, wherein R" is a moiety of the formula - 1 1 I T 1 3 111") 13 SiR R R ", wherein each of R , R " and R * is independently C1-C6 alkyl or phenyl. 5. The process of claims 1 to 4, wherein X is chloride. 6. The process of claims 1 to 5, wherein R is C1-C6alkyl. 7. The process of claims 1 to 6, wherein each of R4 and R6 is a moiety of the formula -SiR8R9R10. 8. The process of claims 1 to 7, wherein R7 is H. 9. The process of claims 1 to 8 wherein step a) comprises treating said 8-hydroxy-protected-p-enol ether ester to remove R protecting group to produce a 5—hydroxy-protected-fJ-ketoester of the formula: wherein R1, R2, R3 and R5 are as defined in any of claims 1 to 8. 10. The process of claims 1 to 9 further comprising the step of producing said acyl halide, wherein said acyl halide producing step comprises: (i) treating a p-hydroxy acid of the formula: with a hydroxy protecting group to produce a p-hydroxy-protected ester of the formula: and (ii) treating said p-hydroxy-protected ester with an acyl halogenating agent to produce said acyl halide, wherein R is H, R or a carboxylate counter cation. [ 1. The process of claim 10, wherein each of R" and R14 is a moiety of the formula -SiR15R16R17, wherein each of R15, R16 and R17 is independently C1-C6 alkyl or phenyl. [2. The process of claim 10 or 11 further comprising the step of enantioselectively producing said P-hydroxy acid, wherein said P-hydroxy acid producing step comprises: (A) enantioselectively reducing a P-ketoester of the formula: to enantioselectively produce a P-hydroxy ester of the formula: wherein R18 is CpC6 alkyl, C5-C20 aryl or C6-C20 arylalkyl; and (B) saponifying said p-hydroxy ester to produce said P-hydroxy acid. 13. The process of claim 12, wherein said process produces said 5-lactone having the following stereochemical configuration: 14. The process of claim 13, wherein said process produces said 5-lactone in an enantiomeric excess of at least about 90%. 15. The process of claim 12, wherein said step of enantioselective reduction of said P-ketoester comprises hydrogenation of said P-ketoester in the presence of a hydrogenation catalyst. 16. The process of claim 15, wherein said hydrogenation catalyst is selected from the catalysts as shown in Table 2. 17. The process of claims 15 or 16, wherein said hydrogenation catalyst is a compound of the formula RuCl2((£)-MeOBIPHEP). 18. The process of claim 17, wherein said hydrogenation catalyst is the product produced by contacting a ruthenium diacetate compound of the formula Ru(OAc)2((-R)-MeOBIPHEP) with a halide source. 19. The process of claim 18, wherein the molar ratio of between said halide source and said ruthenium diacetate is at least about 20:1. 20. A process for enantioselective preparation of a p-hydroxy ester of the formula: as defined in any of claims 1 to 18 comprising hydrogenating a P-ketoester of the formula: in the presence of about 40 bar of pressure or less of hydrogen gas and a ruthenium hydrogenation catalyst comprising a halide and a chiral substituted biphenyl phosphorous ligand, wherein R1 is C1-C20 alkyl, and R18 is H or C1-C6 alkyl, C5-C20 aryl or C6-C20 arylalkyl. 21. The process of claim 20, wherein said hydrogen gas is technical grade hydrogen gas. 22. The process of claim 20-21, wherein R1 is undecyl. 23. The process of claim 20 - 22, wherein R is C1-C6 alkyl. 24. The process of claim 20 - 23, wherein said hydrogenation catalyst is selected form the catalysts as defined in claims 16 to 19. 25. A process for enantioselectively producing a 5-lactone of the formula (VII): to produce a 8-siloxy-p-silyl enol ether ester of the formula: (b) treating said 8—siloxy—(3—silyl enol ether ester with a base to remove at least one silyl group; and (d) contacting the product of said step (b) with an acid to produce said S-lactone, wherein R is Q1H23, R is CeHu, R° is Ci-C6 alkyl, C5-C20 aryl or C6-C20 arylalkyl; and each of R8, R9, R10, Ru, R12 and R13 is independently CrC6 alkyl or phenyl. 26. The process of Claim 25> wherein said process produces said 5-lactone in an enantiomeric excess of at least about 90%. 27. The process of Claim 25 - 26, wherein R is C1-C6 alkyl. 28. The process of Claim 25 - 27, wherein said step (b) comprises treating said 8-siloxy-(3—silyl enol ether ester with a base selected from the group consisting of hydroxides and carbonates to desilylate both silyl groups. 29. The process of Claim 25 - 28, wherein said step (b) comprises treating said 8—siloxy—(3—silyl enol ether ester with a bicarbonate to produce a 5-siloxy-p-ketoester of the formula: 30. The process of Claim 25 - 29, wherein said acid is hydrochloric acid. 31. The process of claim 25 - 30 further comprising the step of producing said acyl halide, wherein said acyl halide producing step comprises: (i) treating (i?)-3-hydroxy tetradecanoic acid with a silylating agent to produce a p-siloxy tetradecanoate silyl ester of the formula: and (ii) contacting said p-siloxy tetradecanoate silyl ester with an acyl halogenating agent to produce said acyl halide. 2. The process of claim 31, wherein Ru, R12 and R13 are methyl. 3. The process of claim 31-32, wherein said silylating agent is selected from the group consisting of trimethylsilyl chloride and hexamethyldisilazane. 4. The process of claim 31-33, wherein said acyl halogenating agent is thionyl chloride. 5. The process of claim 31-34 further comprising the step of producing said (R)-3-hydroxy tetradecanoic acid, wherein said (i?)-3-hydroxy tetradecanoic acid producing step comprises: wherein R18 is Q-Ce alkyl, C5-C20 aryl or CVC20 arylalkyl; and (B) saponifying said p-hydroxy ester to produce said (R)-3-hydroxy tetradecanoic acid. )6. The process of claim 35, wherein said step of enantioselective reduction of said fi- ketoester comprises hydrogenation of said P-ketoester in the presence of a hydrogenation catalyst. 57. The process of claim 37, wherein said hydrogenation catalyst is selected from the group as defined in any of claims 15 to 19. 38. A process for the preparation of a 8-lactone of the formula (VII): to produce a 5-hydroxy-P-ketoester of the formula: and (b) contacting said 5-hydroxy-P-ketoester with an acid to produce said 5-lactone, wherein R is CnH23, R" is C6Hi3, R' is Ci-C6 alkyl, C5-C20 aryl or C6-C20 arylalkyl; and each of R11, R and R is independently C1-C6 alkyl or phenyl. 39. The process of claim 38, wherein said process produces said 5-lactone in an enantiomeric excess of at least about 90%. ' 40. The process of claim 38 - 39, wherein R5 is C1-C6 alkyl. 41. The process of claim 38 - 40, wherein said acid is hydrochloric acid. 42. The process of claim 38 - 41 further comprising the step of producing said acyl halide, as defined in claims 31-37. 43. The process of according any of claims 1 to 42 further comprising the steps of c) hydrogenation of a compound of formula (VII) c wherein X+ represents a kation, and PG an OH-protecting group, e) followed by preparation of the free acid of formula (IX), ring formation and cleavage of the group PG to obtain a compound of formula (X) f) followed by deprotection and reaction with N-formyl-S-leucin under Mitsunobu conditions to obtain a compound of formula (XI) t 44. A process according to claim 43 wherein R is Q1H23 and R" is CeH^. 45. A compound selected from the group consisting of a) P-siloxy acyl halides of the formula: b) 5-siloxy-P-silyl enol ether esters of the formula: and c) 5-siloxy-(5-ketoesters of the formula: wherein R is Q-C20 alkyl; R is H or C1-C10 alkyl; RD is Ci-C6 alkyl, C5-C20 aryl or C6-C20 arylalkyl; each of R8, R9, R10, Rn, R12 and R13 is independently Q-Ce alkyl or phenyl; and X is a halide. 46. The compound of Claim 45, wherein said P-siloxy acyl halide is (JR)-3-trimethylsiloxy tetradecanoyl chloride. 47. The compound of Claim 45, wherein said 8-siloxy-P-silyl enol ether ester is selected from the group consisting of methyl (i?)-3,5-bis-(trimethylsiloxy)-2-hexyl-3-hexadecenoate, and ethyl (i?)-3,5-bis-(trimethylsiloxy)-2-hexyl-3-hexadecenoate. 48. The compound of Claim 45, wherein said 5-siloxy-P-ketoester is selected from the group consisting of methyl (5i?)-5-(trimethylsiloxy)-2-hexyl-3-oxo-hexadecanoate, and ethyl (5i^)-5-(trimethylsiloxy)-2-hexyl-3-oxo-hexadecanoate. 49. The use of a process according to any of claims 1-44 for the preparation of orlistat. 50. Compounds prepared by any of the processes as defined in claims 1 to 44. 51. The invention as hereinbefore defined. 52. A process for the preparation of a cf-lactone substantially as herein described and exemplified.

Documents:

84-mas-2001-abstract.pdf

84-mas-2001-claims duplicate.pdf

84-mas-2001-claims original.pdf

84-mas-2001-correspondence others.pdf

84-mas-2001-correspondence po.pdf

84-mas-2001-description complete duplicate.pdf

84-mas-2001-form 1.pdf

84-mas-2001-form 18.pdf

84-mas-2001-form 26.pdf

84-mas-2001-form 3.pdf

84-mas-2001-form 5.pdf

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