Title of Invention	HYDROXYL- FUNCTIONALISED DENDRITIC MACROMOLECULES IN TOPICAL COSMETIC AND PERSONAL CARE COMPOSITIONS
Abstract	1. A cosmetic and personal care composition selected from the group consisting of hairspray compositions, mousses, gels, lotions, tonics, shampoos, and conditioners, wherein said composition comprises a hydroxyl-functionalised dendritic macromolecule.

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FORM2 THE PATENTS ACT, 1970 (39 Of 1970) COMPLETE SPECIFICATION (See section 10; rule 13) Title of the invention HYDROXYL-FUNCTIONALISED DENDRITIC MACROMOLECULES IN TOPICAL COSMETIC AND PERSONAL CARE COMPOSITIONS HINDUSTAN LEVER LIMITED, a company incorporated under the Indian Companies Act, 1913 having its registered office at Hindustan Lever House, 165/166, Backbay Reclamation, Mumbai-400 020, State of Maharashtra, India The following specification describes the nature of this invention (and the manner in which it is to be performed) ORIGINAL IN/PCT/2002/00244/MUM 27/02/02 GRANTED 17-2-2004 HTDROXYL-FUNCTIONALISED DENDRITIC MACROMOLECULES IN TOPICAL COSMETIC AND PERSONAL CARE COMPOSITIONS Field cf the Invention The present invention relates to cosmetic and personal care compositions, such as hair styling compositions, containing. hydroxyl-functionalised dendritic macromolecules. Background and Prior Art Cosmetic and personal care compositions such as hair styling sprays, mousses, gels and shampoos, frequently contain resins, gums and adhesive polymers to provide a variety of benefits, for example, film-forming ability, thickening, sensory properties and hair shaping and setting. Such materials must meet a number of functional requirements. These include for example good hair holding ability and curl retention without giving a harsh, brittle feeling to the hair. Even under humid conditions there must be good hold and curl retention. Another requirement is that the material be capable of being removed upon washing the hair at the time of shampooing. Further important material properties are low stickiness and a lack of powdering or flaking. We have found that hydroxyl-functionalised dendritic macromolecules are a class of material that meets the above 2 requirements in a cosmetic and personal care composition, particularly hair styling compositions such as hairsprays. Dendritic macromolecules are macromolecules with densely branched structures having a large number of end croups. A dendritic polymer includes several layers or generations of repealing units which all contain one or more branch points. Dendritic polymers, including dendrimers and hyperbranched polymers, are prepared by condensation reactions of moncmeric units having at least two different types of reactive groups. Dendrimers are highly symmetric, whereas macromolecules designated as hyperbranched may to a certain-degree hold an asymmetry, yet maintaining the highly branched treelike structure. Dencritic macromolecules normally consist of an initiator or nucleus having one or more reactive sites and a number of branching layers and optionally a layer of chain terminating molecules. Continued replication of branching layers normally yields increased branch multiplicity and, where applicable or desired, increased number of terminal groups. The layers are usually called generations and the branches dendrons. These materials have found such diverse uses as catalysts (and catalyst supports), as selective membranes and coatings, as demulsifiers for oil-in- water emulsions, as wet strength agents in the manufacture of paper, as agents for modifying viscosities in aqueous formulations such as paints, as impact modifiers or as cross-linking agents in plastics, as carriers for agricultural, pharmaceutical and other substances, and as submicron size calibrators. 3 Certain dendritic polymers have been suggested for use in the context of personal care. WO97/14404 describes personal wash compositions containing an anionic surfactant as a cleaning agent and a cationic dendrimer as a mildness aid. The preferred cationic dendrirners are polyamidoamine (PAMAM) dendrirners prepared by sequential reactions of ethylenediamine and methyl acrylate. US 5 449 519 relates to keratolytic or anti-acne compositions in which the keratolytic or anti-acne agent (e.g. salicylic acid) is complexed with a starburst dendrimer of the PAMAM type. EP 0 880 961 and EP 880 962 describe anti-solar preparations for protection of skin and hair containing a hyperbranched or dendrimeric polyamino-polymer such as hyperbranched polyethyleneimine. EP 0 858 797 describes deodorant compositions comprising dendrirners having primary amine terminal groupings. EPO 884 047 relates to the use of polyamine polymers; which may be hyperbranched or dendrimeric, as antioxidant agents for cosmetic or dermatological compositions. WO 99/32076 and WO 99/32540 concern the use of certain specific disulphide-functionalised hyperbranched polymers and dendrirners in cosmetics and pharmaceuticals as thickening or gelling agents or as film-forming agents. EP 0 815 827 describes cosmetic compositions for treating the hair with a content of at least one dendrimer or 4 dendrimer conjugate in a cosmetic base. The compositions preferably contain dendrimers that are prepared from a 1,4-diaminobutane nucleus via the stepwise Michael addition of acrylonitrile followed by catalytic hydrogenation of cyano groups to amino groups. These dendrimers are referred to as poly(iminopropane-1,3-diyl) dendrimers with nitrile or amino terminal groups and their preparation is describes in US 5,530,092. The compositions are said to provide an appreciable reduction in combing force, based on tests in aqueous solution comparing examples of the above described nitrile/amino functionalised dendrimers with standard hair care polymers such as vinylpyrrolidone/dimethylaminoethylmethacrylate copolymer. None of the above documents disclose or suggest the utility of dendritic polyols in cosmetic and personal care compositions such as hair styling compositions. Summary of the Invention The present invention provides a cosmetic and personal care composition comprising a hydroxyl-functionalised dendritic macromolecule. Detailed Description Hydroxyl-functionalised dendritic macromolecule The composition of the present invention preferably contains a hydroxyl-functionalised dendritic macromolecule that is ouilt up from polyester units. 5 Suitable materials are described in S3 468 771, which discloses a macromolecule which is composed of an initiator, having a: least one hydroxyl group, to which initiator is added at least one branching generation comprising at leas-one chain extender, having at least one carboxyl group and at least two hydroxyl groups. Further suitable materials are described in 3E 503 342, in which the macromolecule is substantially composed of a nucleus, having at least one epoxide group, to which nucleus is added at lease one branching generation comprising at lease one chain extender, having at least three reactive functions of which at least one is a carboxyl or epoxide group and at least one is a hydroxyl group. The above described materials are also referred to as polyhydric polyester alcohols or hyperbranched polyols. Preferably these materials have at least eight, more preferably at least sixteen, most preferably at least thirty-two terminal hydroxyl groupings per macromolecule. Their molecular weight is preferably at least 800, more preferably at least 1600, most preferably at least 2500 g/mole. The above materials are available commercially from Perstorp A3, SE-2 84 SO Perstorp, Sweden under the trademark of 30LT0RN. Examples of such materials are B0LT0RN H10, BOLTORN H2 0, 30LT0RN H30 and BOLTORN H4 0, of which BOLTORN H3 0 and BOLTORN H4 0 are preferred. Cosmetic and Personal Care Compositions 6 Compositions of the present invention are preferably formulated into, hair care compositions, especially hairspray compositions, but can also be formulated into a wide variety of product types, including mousses, gels, lotions, tonics, sprays, shampoos, conditioners, rinses, hand and body lotions, facial moisturisers, sunscreens, anti-acne preparations, topical analgesics, mascaras, and the like. The carriers and additional components required to formulate such products vary with product type and can be routinely chosen by one skilled in the art. The following is a description of some of these carriers and additional components. Carriers Kair care compositions of the present invention can comprise a carrier, or a mixture of such carriers, which are suitable for application to the hair. The carriers are present at from about 0.5% to about 99.5%, preferably from about 5.0% to about 99.5%, more preferably from about 10.0% to about 98.0%, of the composition. As used herein, the phrase "suitable for application to hair" means that the carrier does not damage or negatively affect the aesthetics of hair or cause irritation to the underlying skin. Carriers suitable for use with hair care compositions of the present invention include, for example, those used in the formulation of hair sprays, mousses, tonics, gels, shampoos, conditioners, and rinses. The choice of appropriate carrier will also depend on the particular hydroxyl-funcuionalised dendritic macromolecule to be used, and whether the product formulated is meant to be left on the surface to which it is 7 aoplied (e.g., hair spray, mousse, tonic, or gel) cr rinsed off after use (e.g., shampoo, conditioner, rinse). The carriers used herein can include a wide range of components conventionally used in hair care compositions. The carriers can contain a solvent to dissolve or disperse the particular hydroxyl-functionaiised dendritic macromoiecule being used, with water, the C1-C6 alcohols, lower aikyi acetate and mixtures thereof being preferred. The carriers can also contain a wide variety of additional materials such as acetone, hydrocarbons (such as isobutane, hexane, decene), halogenated hydrocarbons (such as Freons) and volatile silicones such as cyclomethicone. When the hair care composition is a hair spray, tonic, gel, or mousse the preferred solvents include water, ethanol, volatile silicone derivatives, and mixtures thereof. The solvents used in such mixtures may be miscible cr immiscible with each other. Mousses and aerosol hair sprays can also utilise any of the conventional propellants to deliver the material as a foam (in the case of a mousse) or as a fine, uniform spray (in the case of an aerosol hair spray). Examples of suitable propellants include materials such as-trichlorcfluoromethane, dichlorodifluoromethane, difluoroethane, dimethyiether, propane, n-butane or isobutane. A tonic or hair spray product having a low viscosity may also utilise an emulsifying agent. Examples of suitable emulsifying agents include nonionic, cationic, anionic surfactants, or mixtures thereof. If such an emulsifying agent is used, it is preferably present at a level of from about C.01% to about 7.5% by weight based on total weight of the composition. The level of propellant can be adjusted as desired but is generally from about 3% to 8 about 3 0% by weight based on total weight for mousse compositions and from about 15% to about 50% by weight based on total weight for aerosol hair spray compositions. Suitable spray containers are well known in the art and inclu e conventional, non-aerosol pump sprays i.e., "atomisers", aerosol containers or cans having propellant, as described above, and also pump aerosol containers utilising compressed air as the propellant. Where the hair care compositions are conditioners and rinses the carrier can include a wide variety of conditioning materials. Where the hair care compositions are shampoos, the carrier can include, for example, surfactants, suspending agents, and thickeners. The carrier can be in a wide variety of forms. For example, emulsion carriers, including oil-in-water, water-in-oil, water-in-oil-in-water, and oil-in-water-in-silicone emulsions, are useful herein. These emulsions can cover a broad range of viscosities, e.g., from about 100 cps to about 200,000 cps. These emulsions can also be delivered in the form of sprays using either mechanical pump containers or pressurised aerosol containers using conventional propellants. These carriers can also be delivered in the form of a mousse. Other suitable topical carriers include anhydrous liquid solvents such as oils, alcohols, and silicones (e.g., mineral oil, ethanol, isopropanol, dimethicone, cyclomethicone, and the like); aqueous-based single phase liquid solvents (e.g., hydro-alcoholic solvent systems); and thickened versions of these anhydrous and aqueous-based single phase solvents (e.g., where the viscosity of the solvent has been increased to form a solid 9 or semi-solid by the addition of appropriate gums, resins, waxes, polymers, salts, and the like). Additional Components A wide variety cf additional components can be employed in cosmetic and personal care compositions according to the present invention. Examples include the following: hair styling polymers for hair styling compositions such as hair sprays, gels, and mousses. Hair styling polymers are well known articles of commerce and many such polymers are available commercially which contain moieties which render the polymers cationic, anionic, amphoteric or nonionic in nature. The polymers may be synthetic or naturally derived. The amount cf the polymer may range from 0.5 to 10%, preferably 0.75 to 6% by weight based on total weight of the composition. Examples of anionic hair styling polymers are: copolymers of vinyl acetate and crotonic acid; terpoiymers of vinyl acetate, crotonic acid and a vinyl ester of an alpha-branched saturated aliphatic monocarboxylic acid such as vinyl neodecanoate; copolymers cf methyl vinyl ether and maleic anhydride (molar ratio about 1:1) wherein such copolymers are 50% esterified 10 with a saturated alcohol containing from 1 :o 4 carbon atoms such as ethanol or butanol; acrylic copolymers containing acrylic acid or rnethacryiic acid as the anionic radical-containing moiety with other monomers such as: esters of acrylic or rnethacryiic acid with one or more saturated alcohols having from 1 to 22 carbon atoms (such as methyl methacrylate, ethyl acrylate, ethyl metnacrylate, n-butyl acrylate, t-butyl acrylate, t-butyl methacrylate, n-butyl methacrylate, n-hexyl acrylate, n-octyl acrylate, lauryl methacrylate and behenyl acrylate); glycols having from 1 to 6 carbon atoms (such as hydroxypropyl methacrylate and hydroxyethyl acrylate); styrene; vinyl caprolactam; vinyl acetate; acrylamide; alkyl acrylamiaes and methacrylamides having 1 to 8 carbon atoms in the alkyl group (such as methacrylamide, t-butyl acrylamide and n-octyl acrylamide); and other compatible unsaturated monomers. The polymer may also contain grafted silicone, such as polydimethylsiicxane. Specific examples of suitable anionic h'air styling polymers are: RESYN® 28-2S30 available from National Starch (vinyl acetate/crotonic acid/vinyl neodecanoate copolymer); ULTRAHOLD® 8 available from BASF (CTFA designation Acrylates/acryiamide copolymer); 11 the GANTREZ®ES series available from IS? corporation esterified copolymers of methyl vinyl ether and maleic anhydride). Other suitable anionic hair styling polymers include carboxylated polyurethanes. Carboxylated polyurethane resins are linear, hydroxyl-terminated copolymers having pendant carboxyl groups. They may be ethoxylated and/or propoxylated at least at one terminal end. The carboxyi group can be a carboxylic acid group cr an ester group, wherein the alkyl moiety of the ester group contains one to three carbon atoms. The carboxylated polyurethane resin can also be a copolymer of polyvinylpyrrolidone and a polyurethane, having a CTFA designation PVP/polycarbamyl polyglycol ester. Suitable carboxylated polyurethane resins are disclosed in SP 0 619 111 Al and US Patent No. 5,000,955. Other suitable hydrophilic polyurethanes are disclosed in US Patent Nos. 3,822,233; 4,156,066; 4,156,067; 4,255,550; and 4,743,673. Amphoteric hair styling polymers which can contain cat ionic groups derived from monomers such as t-butyl aminoethvl methacrylate as well as carboxyi groups derived from monomers such as acrylic acid or methacrylic acid can also be used in the present invention. One specific example of an amphoteric hair styling polymer is Amphomer® (Octylaery1amide/acrylates/butylaminoethyl methacrylate copolymer) sold by the National Starch and Chemical Corporation. Examples of nonionic hair styling polymers are homopolymers of N- vinylpyrrolidone and copolymers of N-vinylpyrrolidone with compatible nonionic monomers such as vinyl acetate. 12 Ncnionic polymers containing N- vinylpyrroliaone in various weight average molecular weights are available commercially from ISP Corporation - specific examples of such materials are homopclymers of N-vinylpyrrolidone having an average molecular weight of about 530,000 sold under the name PV? K-9 0 and are homopolymers of N-vinylpyrrolidone having an average molecular weight of about 1,000,000 sold under the name of PV? K-12 0. Other suitable nonionic hair styling polymers are cross-linked silicone resins or gums. Specific examples include rigid silicone polymers such as those described in EP-A-240 350 and cross-linked silicone gums such as those described in WO 96/31188. Examples of cationic hair styling polymers are copolymers of amino-functional acrylate monomers such as lower alkyl aminoalkyl acrylate, or methacrylate monomers such as dimethylaminoethyl methacrylate, with compatible monomers such as N-vinylpyrrolidone, vinyl caprolactam, alkyl methacryiates (such as methyl methacrylate and ethyl methacrylate) and alkyl acrylates (such as ethyl acrylate and n-butyl acrylate). Specific examples of suitable cationic polymers are: copolymers of N-vinyipyrrolidone and dimethylaminoethyl methacrylate, available from ISP Corporation as Copolymer 84 5, Copolymer 937 and Copolymer 958; copolymers of N-vinylpyrrolidone and .dimethylaminopropylacrylamide or methacrylamide, available from IS? Corporation as Styleze ® CC10; 13 copolymers cf N-vinylpyrrclidine and dimethylaminoethyl methacryiate; copolymers of vinylcaprolactam, N-vinylpyrrolidone and dimethylaminoethylmethacrylate; ?oiyquaterrium-4 (a copolymer of diallyidimonium chloride and hydroxyethylcellulose); ?olyquaternium-ll (formed by the reaction cf diethyl sulphate and a copolymer of vinyl pyrrolidone and dimethyl aminoethylmethacrylate), available from IS? as Gafquat® 734, 755 and 7 5 5N, and from BASF as Luviquat® PQ11; ?clyquaterrium-lS (formed from methylvinylimidazolium chloride and vinylpyrrolidone), available from BASF as Luviquat® FC 370, ?C 550, FC 905 and HM-552; Poiyquatemium-45 (prepared by the reaction of vinylcaprclactam and vinylpyrrolidone with methylvinylimidazolium methosulphate), available from BASF as Luviquat ©Hold. Examples of suitable naturally-derived polymers include shellac, alginates, gelatins, pectins, cellulose derivatives and chitosan or salts and derivatives thereof. Commercially available examples include Kytamer® (ex Amerchol) and Amaze® (ex National Starch). With certain of the above-described polymers it may be necessary to neutralise some acidic groups to promote solubility/dispersibility. Examples of suitable neutralising agents include 2-amino-2- methyl-1, 3-propanediol (AM?D); 2-amino-2-ethyl-2,3-propanediol (AEPD); 2-amino-2-methyl-1- 14 propanol (AMP) ; 2-amino-1-bucanol (A3); monoethanclamine (MEA); dienhanolamine (DEA); triethanolamine (TEA); monoisopropanolamine (MIFA) ,- diisopropanol-amine (DIPA); triisopropanolamine (TTPA); and dimethyl stearamine (DMS). A long chain amine neutralising agent such as stearamidopropyl dimethylamine or lauramidopropyl dimethylamine may be employed, as is described in US 4,874,604. Also suitable are inorganic neutralisers, examples of which include sodium hydroxide, potassium hydroxide and borax. Mixtures of any of the above neutralising agents may be used. Amounts of the neutralising agents will range from about 0.001 to about 10% by weight of the total composition. sunscreening agents such as 2-ethylhexyl p-methoxycinnamate, 2-ethylhexyl N,N-dimethyl-p-aminobenzoate, p-aminobenzoic acid, 2-phenylbenzimidazole-5-sulfonic acid, octocrylene, oxybenzone, homomenthyl salicylate, octyl salicylate, 4,4'-methoxy-t-butyldibenzoylmethane, 4-isopropyl dibenzoylmethane, 3-benzylidene camphor, 3 -(4-methylbenzylidene) camphor, titanium dioxide, zinc oxide, silica, iron oxide, and mixtures thereof. anti-dandruff actives such as zinc pyrithione, piroctone olamine, selenium disulphide, sulphur, coal tar, and the like. hair conditioning agents such as hydrocarbons, silicone fluids, and cationic materials. The hydrocarbons can be either straight, or.-branched chain and can contain from about 10 to about 15, preferably from about 12 to about 16 carbon atoms. Examples of suitable hydrocarbons are decane, dodecane, tetradecane, tridecane, and mixtures thereof. 15 Examples of suitable silicone conditioning agents useful herein can include either cyclic or linear polydimethylsiloxanes, phenyl and alkyl phenyl silicones, and silicone ccpolyols. Cationic conditioning agents useful herein can include quaternary ammonium salts or the salts of fatty amines. surfactants for hair shampoo and conditioner compositions. For a shampoo, the level is preferably from about 10% to about 30%, preferably from 12% to about 25%, by weight based on total weight of -he composition. For conditioners, the preferred level of surfactant is from about 0.2% to about 3%, by weight based on total weight of the composition. Surfactants useful in compositions of the present invention include anionic, nonionic, cationic, zwitterionic and amphoteric surfactants. carboxylic acid polymer thickeners for hair shampoo and conditioner compositions. These crosslinked polymers contain one or more monomers derived from acrylic acid, substituted acrylic acids, and salts and esters of these acrylic acids and the substituted acrylic acids, wherein the crosslinking agent' contains' two or more carbon-carbon double bonds and derived from a polyhydric alcohol. Examples of carboxylic acid polymer thickeners useful herein are those selected from the group consisting of carbomers, acrylates/C10-C3C alkyl acrylate crosspolymers, and mixtures thereof. Compositions of the present invention can comprise from about C.025% to about 1%, more preferably from about 0.05% to about 0.75% and most preferably from about 0.10% to about 0.50% of the carboxylic acid polymer thickeners, by weight based on total weight cf the composition. 16 EXAMPLES Examples 1 to 3 The following hairspray formulations were made up, having ingredients shown in the Table below: % WEIGHT Ex. 1 Ex, 2 Ex.3 ?olycl(1) 0.02 0.2 1.0 AMpKOMER©U1 1.98 1.8 1.0 2-Amino-2-methyl-l-propanol 0.2 97 C.2 7 0.15 SILWET© L-7S02 (3) 0.10 0.10 0.10 DC200/l0cst(4) 0.10 0.10 0.1O Perfume 0.15 0.15 0.15 WATER 2.0 2.0 2.0 ETHANOL 60.353 60.38 60.15 CAP 40(5) 3 5.0 3 5.0 3 5.0 (1) BQLTORN ® K4 0, ex Perstorp A3 (2) Octyiacrylamide/acrylates/butylaminoethyl methacrylate copolymer, ex National Starch (3 Dimethicone copolyol, ex OSi Specialities Dimethicone fluid, viscosity 10 est, ex Dow Corning Hydrocarbon propeliant 17 The formulations of Examples 1 to 3 were tested against a control formulation in which the polyol(1) was omitted. In the tests, each of the formulations were sprayed individually onco hair samples. 12 panellists were then asked to make a comparative assessment of the hair samples so created across a range of attributes. Overall, the formulations of Examples 1 to 3 were clearly preferred to the control on the positive attributes of strength of hold imparted to the hair and softness of feel imparted to the hair. The formulations of Examples 1 to 3 also gave perceivably less stickiness and deposits on the hair (both of which are undesirable attributes for a hairspray), compared with the control. Example 4 The polyol(1) was evaluated by itself in ethanol solution for the properties of film formation, wash off and bond strength. The results were as follows: Film Formation: Films cast from 10% w/v ethanol solutions of polyol(2) produced clear non-tacky films. Wash Off: A hair swi (10.25g of 2 inch Spanish hair) was coated with a 5% w, Vethanol solution of polyol(2) and air dried for 3 hours. The switch was washed with water only and air dried overnight. No residues were visible and no material coating 18 could be felt. FT-IR AR analysis confirmed no polyol(1) present on hair surface. Bond Strength: Diastron MTT600 analysis of crossed hair fibres in which 1 microlitre of 5% w/v ethanol solution of polyol((2) had been pipetted onto the fibre-fibre junction showed that the :polyol(2) was capable of bonding to hair with an average bond strength of 18.38g. For the purposes of comparison, a PAMAM Starburst cendrimer generation i (ex Aldrich) was subjected to an equivalent evaluation for the properties of film formation, wash off and bond strength. In contrast, this material did not form films or bond to hair and showed inferior wash off properties. 19 We claim : 1. A cosmetic and personal care composition selected from the group consisting of hairspray compositions, mousses, gels, lotions, tonics, shampoos, and conditioners, wherein said composition comprises a hydroxyl-functionalised dendritic macromolecule. 2. A composition as claimed in claim 1, wherein the hydroxyl-functionalised dendritic macromolecules is built up from polyester units. 3. A composition as claimed in claim 1 or 2, wherein the composition is formulated as a hairspray, gel or mousse. 4. A composition as claimed in claim 3, further comprising an anionic, nonionic, cationic or amphoteric hair styling polymer. 5. A composition as claimed in claim 3 or 4 further comprising an aerosol propellant. Dated this 27th day of February, 2002 Dr.Sanchita Ganguli Of S.MAJUMDAR & CO. Applicant's Agents

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