Title of Invention | "A PROCESS FOR PREPARING A NOVEL HERBAL FORMULATION FOR THE TREATMENT OF MANGE IN ANIMALS" |
---|---|
Abstract | The invention relates to a process of preparing a formulation for the treatment of mange in different species of livestock, wherein essential oil of Eucalyptus leaves and castor oil are used. Essential oil of Eucalyptus leaves and castor oil are mixed in the ratio of 15:85 for preparing the formulation for large animals and 8:92 for the small animals. The formulation is very effective in the treatment of mange in different species of livestock and is cheaper. |
Full Text | This invention relates to a process for preparing the composition for the treatment of mange infection in animals. Mange infection is a contageous disease, caused by mites such as Sarcoptic scabei, Psoroptic scabei and Demodeclic scabei, which spreads amongst the animals by contact. The disease causes damage to the skin, thereby the economic value of hides and skin is adversely affected. Sometimes, it may spread to human beings, who come in contact with the affected animals. The available medications have certain limitations like recurrence of infection on discontinuation of treatment, besides being costly. Medicines from plant sources have contributed significantly in the treatment of animal diseases. One such ethnobotanical is Eucalyptus sp. The essential oil from the leaves of Eucalyptus has been used as antiseptic in respiratory infections, in certain skin diseases, as ointment in burn and as mosquito repellents (Wealth of India, 1952; British Veterinary Codex, 1953). In view of the magnitude of mange (Scabies) in animals and the importance of effective management of such cases, it is imperative to develop an effective remedy from the essential oil of Eucalyptus leaves. With this objective in view, composition from the essential oil of Eucalyptus useful in the treatment of mange was developed. Another objective of the invention was to provide method of preparation for the treatment of mange infection and employing the same. Since the essential oil of leaves was reported to be useful in skin diseases, its potentiality as a remedy in mange infection has been tested. 3.2. Specifications Steam-distilled essential oil of Eucalyptus leaves should be light-yellow in colour and can be stored in air-light containers. 3.3. Evaluation A. Efficacy The formulation was applied in naturally-infecled cow calves, buffalo calves and goats. The animals were positive for Sarcoptic scabei and Psoroptic scabei. Application of the formulation showed complete recovery from infection in these species. Skin scrapings from treated animals were examined and found to be free from mites. B. Safety Evaluation The oral LD50 value of herbal formulation was found to be more than 27.4g/kg body weight and the mice receiving different doses did not show any toxic symptoms and mortality during 72 h of observation period. Thus, mice tolerated very high doses of formulation, which indicates that the formulation is safe. The formulation did not affect the 4lh locomotor activity, pentobarbitone sleeping time, amphetamine aggregation toxicity, anticonvulsant and tranquilizing effect, thus, suggesting that it does not affect the nervous system. 3.4. A process for preparing a herbal formulation for the treatment of mange in animals I. A process of preparing herbal formulation for the treatment of mange in animals, wherein essential oil of Eucalyptus leaves and castor oil are mixed in a ratio of 15 : 85 (V/V) for large animals (cattle, buffalo, camel etc.) and 8 : 92 (V/V) for small animals (sheep, goat and dog). II. A process as claimed I, wherein essential oil of Eucalyptus is mixed in castor oil in above ratio slowly at a temperature between 15 and 20°C with continuous shaking and stirring till a homogeneous mixture is obtained. III. The formulation so obtained is to be stored in airtight containers. IV. A process for preparation of herbal formulation as herein described. 3.5. Mode of application The formulation, so obtained, is applied after clipping the hair of affected parts and removing the crust with brush. The formulation is applied once daily. For mild infection, four applications are sufficient, two applications on consecutive days and two more applications on alternate days. In heavy infections, the formulation is applied once daily for 10 consecutive days. The distinct advantage of the castor oil in formulation is to soften the crust, thereby allowing the medicine to be in close contact. Formulation is effective in lice and tick infestation in cattle and poultry also. Vascular permeability increasing action coupled with antibacterial and insect repellant effect of the formulation may be highly beneficial for promotion of wound healing at the site of local application. 3.6. Quality Control The standards for quality control of herbal preparations are difficult to apply in the present day situations. For testing the identity of the formulation, demonstration of in vivo acaricidal activity has been tested. 3.7. Utility of the formulation i. The formulation is effective in the treatment of mange infection in different species of livestock and it is comparalively more efficacious than other available drugs and the recurrence of infection is negligible. ii. Eucalyptus oil is a byproduct of social forestry and the preparation of the formulation is technologically and economically viable. iii. The formulation is easy to apply. iv. The formulation is cheaper. v. It is eco-friendly. vi. Shelf-life is long. REFERENCES Wealth of India (1952). Raw material, Vol. 9: Raw Material, Vol. 3 D- E, Publication and Information Directorate, CSIR, New Delhi, p. 213. British Veterinary Codex (1965). Pharmaceutical Society of Great Britain, Pharmaceutical Press, 17, Bloomsbury Square, WC1, London, p. 161. 4. I/We Claim that: A process of preparing herbal composition for the treatment of mange in animals, wherein essential oil of Eucalyptus leaves and castor oil are mixed in ratio of 15:85 (v/v) for animals like buffalo, camel and 8:92 (v/v) for animals like sheep and dog at a temperature between 15-20c. |
---|
943-del-2002-correspondence-others.pdf
943-del-2002-correspondence-po.pdf
943-del-2002-description (complete).pdf
Patent Number | 210526 | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Indian Patent Application Number | 943/DEL/2002 | ||||||||||||
PG Journal Number | 41/2007 | ||||||||||||
Publication Date | 12-Oct-2007 | ||||||||||||
Grant Date | 05-Oct-2007 | ||||||||||||
Date of Filing | 17-Sep-2002 | ||||||||||||
Name of Patentee | INDIAN COUNCIL OF AGRICULTURAL RESEARCH | ||||||||||||
Applicant Address | KRISHI BHAWAN, DR. RAJENDRA PRASAD ROAD, NEW DELHI-110001, INDIA. | ||||||||||||
Inventors:
|
|||||||||||||
PCT International Classification Number | A61K 35/78 | ||||||||||||
PCT International Application Number | N/A | ||||||||||||
PCT International Filing date | |||||||||||||
PCT Conventions:
|