Title of Invention

METHOD FOR INHIBITING THE EXPRESSION OF A TARGET GENE

Abstract

Medicament for inhibiting the expression of a target gene in a cell, containing a double-stranded ribonucleic acid (dsRNA I) in a dosage sufficient to inhibit the expression of the target gene, wherein dsRNA I exhibits a double-stranded structure consisting of a maximum of 49 successive nucleotide pairs, and wherein one strand (asl) or at least one segment of the strand (asl) of the double-stranded structure is complementary to the target gene, and wherein at least one end (El, E2) of the dsRNA I exhibits an overhang consisting of 1 to 4 nucleotides.

Full Text

FORM 2 THE PATENTS ACT, 1970 (39 of 1970) COMPLETE SPECIFICATION (See Section 10) METHOD FOR INHIBITING THE EXPRESSION OF A TARGET GENE RIBOPHARMA AG of UNIVERSITATSSTR. 30, 95447 BAYREUTH, GERMANY, GERMAN Company The following specification particularly describes the nature of the invention and the manner in which it is to be performed : - The invention concerns a method, a use, and a medicament for inhibiting expression of a target gene. Methods to inhibit the expression of medically or biotechnologically interesting genes using a double-stranded ribonucleic acid (dsRNA) are known from WO 99/32619 and WO 00/44895. Although the known methods are highly effective, there is nonetheless a need to further enhance their efficiency. The object of the present invention is to remove the shortcomings in accordance with the state-of-the-art. In particular, a method, a use, and a medicament are to be disclosed, by which even more efficient inhibition of the expression of a target gene is achievable. This object is solved by the features of Claims 1, 41, and 81. Advantageous embodiments result from features of Claims 2 to 40,42 to 80, and 82 to 120. Surprisingly, with the features claimed in this invention, a drastic enhancement is achieved in the effectiveness of inhibition of the expression of a target gene in vitro and in vivo. As a result of the particular formation of the dsRNA ends, both their efficiency in mediating the inhibitory action on the expression of a target gene as well as their stability can be affected in a targeted way. Active concentration in the cells is enhanced as a result of this enhanced stability. In terms of the invention, "target gene" is understood to mean the DNA strand of a double-stranded DNA in the cell, which is complementary to a DNA strand, including all transcribed regions, that serves as a matrix for transcription. In other words, the "target gene" is generally the sense strand. One strand, or antisense strand (asl) can be complementary to an RNA transcript or its processing products, e.g., an mRNA, formed during expression of a target gene. The term "introduced into" is understood to mean uptake in the cell. Uptake may occur by means of the cell itself. However, it may also be mediated by auxiliary agents or devices. "Overhang" is understood to mean a single-stranded projection located at an end, which does not exhibit Watson-Crick paired nucleotides. "Double-stranded structure" is understood to mean a structure in which the nucleotides of the individual strands are generally paired in accordance with Watson & Crick. In terms of the present invention, a double-stranded structure may also exhibit individual mismatches. In a particularly advantageous embodiment, dsRNA I exhibits the overhang at the 3'-end of the strand or antisense strand asl and/or at the 3'-end of the other strand or antisense strand ssl. dsRNA I may also be smooth at one end. In this case, the smooth end is advantageously located on the side of dsRNA I that (exhibits)1 the 5'-end of a strand (antisense strand; asl). In this embodiment, dsRNA I exhibits very good effectiveness as well as great stability in the living organism. Total in vivo effectiveness is outstanding. The overhang consists advantageously of 1 to 4 nucleotides, preferably of 1 or 2 nucleotides. In accordance with a further embodiment, the effectiveness of the method can be further enhanced when at least one further dsRNA II corresponding to the dsRNA I in the invention is introduced into the cell, whereby one strand, or at least a segment of one strand of the double-stranded structure of dsRNA I is complementary to a first region of the sense strand of the target gene, and whereby another strand, or at least a segment of the other strand of the double-stranded structure of the dsRNA II is complementary to a second region of the sense strand of the target gene. Inhibition of expression of the target gene is markedly enhanced in this case. The first and second region can overlap segmentally, be adjacent to each other, or be separated. It has further been shown to be advantageous when the dsRNA I and/or the further dsRNA II is fewer than 25 successive nucleotide pairs in length. A length of between 19 and 23 nucleotide pairs has been shown to be particularly effective. Efficiency can be further enhanced when single-stranded overhangs containing 1 to 4 nucleotides are present in the double strands preferably formed by 19 to 23 nucleotide pairs. The target gene can, in accordance with a further embodiment, exhibit one of the sequences SQ001 to SQ140 shown in the appended sequence protocol. It may be selected from the following group: an oncogene; cytokinin gene; Id protein gene; prion gene; gene that expresses molecules that induce angiogenesis, adhesion molecules, and cell surface receptors; genes of proteins that are involved in metastasizing and/or invasive processes; genes of proteinases as well as of molecules that regulate apoptosis and the cell cycle; genes that express the EGF receptor. In particular, the target gene can be a MDR1 gene. It may be used in this connection a dsRNA I/II consisting of one of the sequences SQ141-173 or a combination of one of the antisense (as) and sense sequences (ss) that belong together. In accordance with another advantageous embodiment, expression is inhibited according to the principle of RNA interference. The target gene is advantageously expressed in pathogenic organisms, preferably in Plasmodia. It can be a component of a virus or viroid, particularly a virus or viroid that is pathogenic in humans. The virus or viroid can also be one that is pathogenic in animals or plants. In another embodiment, it is provided that the unpaired nucleotides are substituted by nucleoside thiophosphates. At least one end of the dsRNA I/II may be modified to counteract decomposition in the cell or dissociation in the individual strands. Advantageously, the cohesion of the double-stranded structure that results from the complementary nucleotide pairs is enhanced by at least one chemical bond. The chemical bond may be achieved either by a covalent or ionic bond, a hydrogen bond, hydrophobic interaction, preferably by means of van der Waals or stacking interactions, or by means of metal-ion coordination. In addition, it has also been shown to be advantageous and stability-enhancing if the chemical bond occurs in the vicinity of one end. Other advantageous embodiments with regard to chemical bonding can be found in the features in Claims 24 to 30, and no further explanation is required. dsRNA I/II may be particularly easily introduced into the cell when it is enclosed in micellar structures, preferably in liposomes. For the transport of dsRNA I/II into the cell, it has been found to be advantageous that they be bound, associated, or enclosed by at least one viral coat protein that stems directly from a virus, is derived from it, or is synthetically produced. The coat protein may be derived from a polyoma virus. In particular, the coat protein may contain Virus Protein 1 and/or Virus Protein 2 of the polyoma virus. In accordance with a further embodiment, it is provided that during formation of a capsid or capsid-like structure from coat protein, one side is turned to the interior of in the capsid or capsid-like structure. Furthermore, it is advantageous that one strand of the dsRNA I/II (asl/2) is complementary to the primary or processed RNA transcript of the target gene. The cell may be either a vertebrate cell or a human cell. Furthermore, it has been demonstrated that dsRNA I/II may be administered to mammals, preferably human beings, even at a maximum dose of 5 mg/kg body weight per day. Even at this low dosage effectiveness is outstanding. Surprisingly, it has been shown that dsRNA I/II may be mixed in a buffer solution and then administered orally or by injection or infusion, either intravenously, intratumorally, intraperitoneally, or inhalationally. Furthermore, the invention provides the use of a double-stranded ribonucleic acid (dsRNA I) to inhibit expression of a target gene in the cell, whereby dsRNA I exhibits a double-stranded structure consisting of a maximum of 49 successive nucleotide pairs, and whereby one strand (antisense strand, asl) or at least one segment of the strand of the double-stranded structure is complementary to the sense strand of the target gene, and whereby dsRNA I exhibits an overhang at one end consisting of 1 to 4 nucleotides. In accordance with another measure of the invention, a medicament containing one double-stranded ribonucleic acid (dsRNA I) in a quantity sufficient to inhibit expression of the target gene in a cell is provided, whereby dsRNA I exhibits a double-stranded structure consisting of a maximum of 49 successive nucleotide pairs, and whereby one strand (asl) or at least one segment of one strand (asl) of the double-stranded structure is complementary to the sense strand of target gene, and whereby the dsRNA I exhibits at least one overhang at one end consisting of 1 to 4 nucleotides. Refer to the previous discussion for other advantageous embodiments of dsRNA I/II, The invention will be explained on the basis of drawings and examples as follows. These show: Fig. la, b diagram of a first and second double-stranded RNA and Fig. 2 diagram of a target gene, Fig. 3 relative YFP fluorescence after application of various dsRNAs in NIH/3T3 cells (first experiment), Fig. 4 relative YFP fluorescence after application of various dsRNAs in NIH/3T3 cells (second experiment), Fig. 5 relative YFP fluorescence after application of various dsRNAs in NIH/3T3 cells (third experiment), Fig. 6 relative YFP fluorescence after application of various dsRNAs in NIH/3T3 cells (fourth experiment), Fig. 7 relative YFP fluorescence after application of various dsRNAs in Hela-S3 cells (fifth experiment), Fig. 8 fluorescence microscopic imaging of NIH/3T3 cells after transfection with pcDNA-YFP or after cotransfection with pcDNA-YFP and various dsRNAs, Fig. 9 fluorescence microscopic imaging of HeLa-S3 cells after transfection with pcDNA-YFP or after cotransfection with pcDNA-YFP and various dsRNAs, Fig. 10 gel electrophoretic separation of SI after incubation in mouse serum, Fig. 11 gel electrophoretic separation of SI after incubation in human serum, Fig. 12 gel electrophoretic separation of S7 after incubation in mouse serum, Fig. 13 gel electrophoretic separation of S7 after incubation in human serum, Fig. 14 gel electrophoretic separation of K3 after incubation in mouse serum, Fig. 15 gel electrophoretic separation of PKC1/2 after incubation in mouse serum, Fig. 16 gel electrophoretic separation of S1A/S4B after incubation in human serum, Fig. 17 gel electrophoretic separation of K2 after incubation in human serum, and Fig. 18 GFP-specific immunoperoxidase staining of kidney paraffin sections from transgenic GFP mice, Fig. 19 GFP-specific immunoperoxidase staining of heart paraffin sections from transgenic GFP mice, Fig. 20 GFP-specific immunoperoxidase staining of pancreas paraffin sections from transgenic GFP mice, Fig. 21 Western blot analysis of GFP expression in plasma, Fig. 22 Western blot analysis of GFP expression in kidney, Fig. 23 Western blot analysis of GFP expression in heart, Fig. 24 Western blot analysis of EGFR expression in U-87 MG glioblastoma cells, Fig. 25a Northern blot analysis of the MDRI mRNA level in colon carcinoma cell line LS174T, whereby the cells were harvested after 74 hours, Fig. 25b quantification of the bands in Figure 25a, whereby the averages are represented by two values, Fig. 26a Northern blot analysis of the MDRI mRNA level in colon carcinoma cell line LS174T, whereby the cells were harvested after 48 hours, Fig. 26b quantification of the bands in Figure 26a, whereby the averages of two values are represented, Fig. 27 comparison of a transmitted light- and fluorescence microscopic imaging of a transfection with 175 nM dsRNA (Sequence Rl in Table 4). The double-stranded ribonucleic acids dsRNA I and dsRNA II depicted schematically in Figures la and lb each exhibit a first end (El) and a second end (E2). The first and the second ribonucleic acids dsRNA I/dsRNA II exhibit single-stranded segments at both ends (El, E2), being formed of approximately 1 to 4 unpaired nucleotides. Two possible variants are shown (Variants 1 and 2), whereby Variant 2 exhibits a smooth end (E2). The smooth end may, however, be situated at the other end (El) in other variants. Figure 2 shows schematically a target gene located on a DNA. The target gene has been made visible by means of a black line. It exhibits a first region (Bl) and a second region (B2). In each case, one strand of the first dsRNA I (asl) or of the second dsRNA II (as2) is complementary to the corresponding region Bl or B2 in the target gene, respectively. Expression of the target gene is inhibited particularly effectively when dsRNA I/dsRNA II exhibits single-stranded segments at their ends (El, E2). The single-stranded segments may be located both on strand asl or as2, or on anti-strand (ssl or ss2), or on strand asl, as2, and on the anti-strand. Regions Bl and B2 may be separated from each other as shown in Figure 2. However, they may also adjoin or overlap. I. Inhibition of the expression of the YFP gene in fibroblasts: Double-stranded RNAs were derived from sequences of Yellow Fluorescent Proteins (YFP), a variant of GFP (Green Fluorescent Protein) from the Aequoria victoria alga, and microinjected into fibroblasts together with a YFP-coding plasmid. Subsequently, the decrease in fluorescence compared to cells without dsRNA was analyzed. Experiment protocol: Single RNA strands and their complementary single strands were synthesized from sequence protocols SQ148, SQ149 and SQ159, using an RNA synthesizer (Expedite 8909, Applied Biosystems, Weiterstadt, Germany) and conventional chemical processes. These were subsequently purified using HPLC. Hybridization of the individual strands into double strands was done by heating up the stochiometric mixture of the single strands in 10 mM of sodium phosphate buffer, pH 6.8, and 100 mM NaCl to 90°C, and then allowing it to cool off slowly for 6 hours to room temperature. The dsRNA that was obtained in this way was microinjected into the test cells. The test system used for this cell culture experiment was the murine fibroblast cell line NIH/3T3, ECACC No. 93061524 (European Collection of Animal Cell Culture). The pcDNA-YFP plasmid, which contains an 800bp Bam HI/Eco RI-YFP fragment in the corresponding restriction site of the pcDNA3 vector, was used for the microinjections. Expression of YFP under the influence of simultaneously transfused sequence-homologous dsRNA was studied. Analysis of green fluorescence under the fluorescence microscope was done 3 hours after injection at the earliest. Preparation of the cell cultures: The cells were incubated in DMEM with 4.5 g/1 glucose and 10% fetal calf serum (FCS), 2 mM L-glutamine, and penicillin/ streptomycin (100 IU/100 pg/ml, Biochrom) in an incubator in an atmosphere containing 5% CO2 at 37°C. The cells were passaged every 3 days in order to maintain them in an exponential growth state. One day before transfection, the cells were trypsinized (lOx trypsin/TEDTA, Biochrom) and placed in coated petri dishes (CORNING Cell Culture Dish, 35 mm, Corning Inc., Corning NY) at a cell density of 0.3x 105. The petri dishes were incubated for at least 30 minutes at 37°C with 0.2% gelatin (Biochrom), washed once with PBS, and used immediately to culture the cells. In order to find the individual cells again, CELLocate coverslips were used (square sized 55pm, Eppendorf). Microinjection: The petri dishes were taken out of the incubator approximately 10 minutes prior to microinjection. Approximately 50 cells per dish and per incubate were microinjected (Femtojet, Micromanipulator 5171, Eppendorf). Glass capillaries (FemtoTip, Eppendorf) with an internal tip diameter of 0.5 urn were used. Injection time was 0.8 seconds at a pressure of 30 hPA. Microinjection took place under an Olympus 1X50 microscope equipped for fluorescence. The injection buffer used consisted of 14mM NaCl, 3 mM KC1, and 10 mM KH2PO4, pH 7.0, which contained 0.01 ug/ul pcDNA-YFP. An injection solution of 0.08% (w/v) Texas red coupled with dextran 70000 (Molecular Probes, Leiden, Netherlands) was added to test for successful microinjection. In order to analyze the inhibition of YFP expression with specific dsRNA, dsRNAs were added to the injection solution: Assay 1: 0.01 uM dsRNA (sequence protocol SQ148/149); Assay 2: 0.01 uM dsRNA (sequence protocol SQ148/159); Assay 3: without RNA. After microinjection, the cells were incubated for at least another 3 hours in an incubator. Intracellular YFP fluorescence was then analyzed under the microscope: the cells that fluoresced both red and green simultaneously: microinjection was successful, no inhibition of YFP expression as a result of dsRNA was observed, or there were control cells into which no dsRNA was injected; only red fluorescent cells: microinjection was successful, dsRNA inhibited YFP expression. Results: At a dsRNA concentration of 0.1 µM, the use of dsRNA with single-stranded regions with two-nucleotide overhangs each at both 3'-ends (sequence protocol SQ148/159) markedly enhanced inhibition of the expression of the YFP gene in fibroblasts in comparison to dsRNA without end having single overhanging strands (Table 1). The use of short dsRNA molecules, containing 19-25-base pairs with overhangs consisting of a few, preferably 1 to 3, non-base-paired single-stranded nucleotides thus makes possible a comparatively more powerful inhibition of gene expression in mammalian cells than does the use of dsRNAs with the same number of base pairs without the corresponding single-stranded overhangs at the same RNA concentrations. Assay Name Sequence protocol No. 0.1 uM rH SIA/ SIB SQ148 SQ149 + 2 SIA/ S4B SQ148 (overhanging ends) SQ159 +++ 3 Without RNA - Table 1: The symbols give the relative proportion of non- or weakly-fluorescent cells (+++ > 90%; ++ 60-90%-+ 30-60%; - II. Inhibition by dsRNA of gene expression of a target gene in cultured HELA-S3 cells and mouse fibroblasts: The effectiveness of the inhibition of YFP expression after transient transfection of a YFP-coding plasmid on the basis of RNA interference with dsRNA may be modulated by manipulating the 3'-ends and the length of the base-paired region. Example: In order to determine the effectiveness of dsRNA in the specific inhibition of gene expression, transient transfected NIH/3T3 cells (fibroblasts from NIH Swiss mouse embryo, ECCAC [European collection of animal cell culture] No. 93061524) and HELA-S3 (human cervical cancer cells, DSMZ [German collection of microorganisms and cell cultures] No. ACC 161) were used. The pcDNA-YFP plasmid, containing an 800-bp Bam HI/Eco RI-YFP fragment in the corresponding cleaving sites of the vector pcDNA 3, was used for transfection. Double-stranded RNAs (dsRNAs) derived from the sequence of the yellow fluorescent protein (YFP) were produced and transiently transfected into the fibroblasts along with the pcDNA-YFP plasmid (the antisense strands of the specific dsRNAs used are complementary to the corresponding segments of the gene sequences of both YFP and GFP). The reduction in fluorescence was quantified after 48 hours. Cells that were either transfected only with pcDNA-YFP or with pcDNA-YFP and a control dsRNA (not derived from the YFP sequence) were used as controls. Test protocol: dsRNA synthesis: The individual RNA strands seen in the sequence protocols as well as their complementary single strands were synthesized using an RNA synthesizer (Expedite 8909, Applied Biosystems, Weiterstadt, Germany), as well as by conventional chemical means. Purification of the raw synthesis products was then done with the help of the HPLC. The NucleoPac PA-100, 9 x 250 column (Dionex) was used with 20 mM tris, 10 mM NaC104, pH 6.8,10% acetonitrile were used as the low salt buffer, and 20 mM tris, 400 mM NaClCO4, pH 6.8, 10% acetonitrile were used as the high salt buffer. Flow was 3 ml per minute. Hybridization of the single strands into a double-stranded was done by heating the stochiometric mixture of the single strands in 10 mM sodium phosphate buffer, pH 6.8, and 100 mM NaCl to 80-90°C and then allowing it to cool slowly over 6 hours to room temperature. Seeding the cells: All cell culturing was conducted under sterile conditions at an appropriate workstation (HS18/ Hera Safe, Kendro, Heraeus). Culturing of the NIH/3T3 cells and the HELA-S3 was done in the incubator (CO2-incubator T20, Hera Cell, Kendro, Heraeus) at 37°C, 5% CO2, and saturated atmospheric humidity in DMEM (Dulbecco's modified eagle medium, Biochrom) for the mouse fibroblasts, and in Ham's F12 for the HELA cells, with 10% FCS (fetal calf serum, Biochrom), 2 mM L-glutamine (Biochrom), and penicillin/streptomycin (100 IU/100µg/ml, Biochrom). In order to maintain the cells in an exponential growth state, the cells were passaged every 3 days. Twenty-four hours before transfection, the cells were trypsinized (10x trypsin/EDTA, Biochrom, Germany) and placed in a 96-well plate (Multiwell Schalen 96-well, flat-bottom, Schubert & Weiss Laboratories, GmbH) at a cell density of 1.0 x 104 cells/depression and cultured in 150 ul growth medium. Implementation of transient transfection: Transfection was done using Lipofectamine Plus™ reagent (Life Technologies) in accordance with manufacturer directions. 0.15 ug pcDNA-YFP plasmid was placed in each well. The entire transfection volume was 60 µl. In each case, 3 samples were started. First, the plasmid DNA was complexed together with the dsRNA. The plasmid DNA and dsRNA were diluted in serum-free medium, and 1 µl PLUS reagent was used per 0.1 µg of plasmid DNA (in a volume of 10 µl). This was then incubated at room temperature after mixing for 15 minutes. During incubation 0,5 µl lipofectamine was diluted in 10µl serum-free medium per 0,1 fig plasmsid-DNA, well mixed, added to the plasmid/dsRNA/PLUS-mixture and again incubated for 15 minutes. The medium was changed during incubation. The cells were washed once with 200 µl serum-free medium, and thereafter incubated with 40 µl serum-free medium in the incubator until the addition of DNA/dsRNA/PLUS/Lipofectamine. After the addition of 20 µl DNA/dsRNA/PLUS/Lipofectamine per well, the cells were incubated in an incubator for 2.5 hrs. After incubation, the cells were washed once with 200 µl growth medium and incubated in the incubator for 24 hours in 200 µl growth medium until fluorescence detection was done. Fluorescence detection: 24 hours after the last medium change, cell fluorescence was photographed using a fluorescence microscope (IX50-S8F2,U-ULS100Hg fluorescence unit, Brenner U-RFL-T200, Olympus) with a USH I02D mercury lamp (Ushio Inc., Tokyo, Japan), fitted with a WIB fluorescence cube and a digital CCD camera (Orca Illm, Hamamatsu), and a C4742-95 preview monitor. Analysis of the fluorescence images was done using Analysis Software 3.1 (Soft Imaging System GmbH, Germany. In order to relate YFP fluorescence to cell density, cell nucleus staining was done (Hoechst staining). For this the cells were fixed, first in 100 µl methylcarnoy (75% methanol, 25% glacial acetic acid) for 5 minutes, and then again for 10 minutes in methylcarnoy. After air drying, the fixed cells were incubated in the dark for 30 minutes with 100 µl Hoechst stain per well (75 ng/ml). After washing twice with PBS (Dulbecco PBS w/o Ca2+, Mg2+, Biochrom), the cells that had been Hoechst stained were photographed under the fluorescence microscope (Olympus, WU fluorescence cube for Hoechst). The results regading inhibition of YFP expression in cultivated cells by dsRNA are summarized in Figures 3 to 9: The effects of YFP-specific dsRNAs and of control dsRNAs on YFP expression in NIH/3T3 mouse fibroblasts after transient transfection are summarized in Figures 3, 4, 5, and 6. The experiments were carried out as described in the test protocol. The concentration of dsRNA relates to the concentration in the medium during the transfection reaction. The dsRNA designations may be seen in Table 2. It shows the relative fluorescence per photographic image in terms of surface percentage. Three different photographic images were analyzed per well. The average values are obtained from the three images. Specific inhibition of YFP-gene expression by dsRNAs in HELA-S3 cells is shown in Figures 7 and 9. Figure 7 shows the inhibiting action of variously configured dsRNA constructs (Table 2) in various concentrations on expression of YFP in HeLa cells. Figure 8 shows representative fluorescence microscopic images of NIH/3T3 mouse fibroblasts transiently transfected with YFP, without dsRNA and with specific anti-YFP-directed dsRNAs (lOOx enlargement). 8A: YFP control 8B: SI, 10 nM 8C: S4,10 nM 8D: S7,10 nM 8E: S7/S11,1 nM 8F: S7/S12,1 nM Figure 9 shows representative fluorescence microscopic images of HELA-3S cells transiently transfected with YFP, without dsRNA and with specific anti-YFP-directed dsRNAs (lOOx enlargement). 9A: K2 control, 10 nM 9B: SI, 10 nM 9C: S4,10 nM 9D; S7,10 nM 9E: S7/11,1 nM 9F: S7/12,1 nM 9G: S1A/S4B, 10 nM 9H: YFP control Results: Figure 3 shows that YFP expression after transient cotransfection of mouse fibroblasts with the YFP plasmid and specific anti-YFP-sequence-directed dsRNAs can be particularly effectively inhibited when the 3'-ends of the 22- and 19-base-pair-containing regions of the dsRNAs exhibit single-stranded segments of 2 nucleotides (nt). Whereas the SI dsRNA with smooth 3'-ends exhibits no inhibitory effects on YFP expression at a concentration of 1 nM (relating to the concentration in the cell culture medium during transfection), the S7 dsRNA (19 nucleotide pairs) and the S4 (22 nucleotide pairs), each with 2nt overhangs at both 3'-ends, inhibited YFP expression by 50% and 70%, respectively, in comparison to the corresponding control dsRNAs (K3 and K2). At a concentration of 10 nM, the dsRNA with the smooth ends designated SI inhibits YFP expression by ~65%, whereas the S4 dsRNA inhibits YFP expression by ~93% (Figure 4). The inhibitory effects of the dsRNAs designated as S4 and S7 are concentration-dependent (Figure 3 and 4; see also Figure 7). Figure 4 shows that the single-stranded configuration at both 3'-ends (of the sense and antisense strand) is not necessary for efficient suppression of YFP gene expression. To achieve effective inhibition of YFP expression, only the 2nt overhang at the 3'-end of the antisense strand is necessary. Thus, for both S4 dsRNAs (with 2nt overhangs at both 3'-ends) and S1A/S4B (with one 2nt overhang at the 3'-end of the antisense strand) inhibition of YFP expression at a concentration of 1 nM is ~70%. However, if on the other hand the 2nt overhang is located at the 3'-end of the sense strand (and the 3'-end of the antisense strand does not have a single-stranded region), inhibition of YFP gene expression is 50%. Analogously, inhibition at higher concentrations is considerably better when at least the 3'-end of the antisense strand has a 2nt overhang. A more marked inhibition of YFP expression is achieved when the base-paired region has 21 nucleotide pairs instead of 22 (SI and S4), 20 (S13 or S13/14, or 19 (S7) (Figures 5, 6, and 7). Thus, at a concentration of 5 nM, inhibition of YFP expression by SI (22 base pairings with smooth ends) is -40%, while inhibition by S7/S12 (21 base pairings with smooth ends), also at 5 nM, is -92%. If the dsRNA with 21 base pairings exhibits another 2nt overhang at the antisense strand 3'-end (37/511), inhibition is -97% (compared with -73% inhibition by S4 and -70% inhibition by S7). III. Analysis of serum stability of double-stranded RNA (dsRNAV The object is to take the effectiveness of the inhibition on the gene expression of target genes mediated by dsRNAs found in cell cultures and enhance it for use in vivo. This is achieved by improving the stability of dsRNA in serum, and by increasing the retention time of the molecule in the blood circulation, or by increasing the effective concentration of the functional molecule that results from the foregoing. Example: Serum stability of GFP-expression-inhibiting dsRNAs was tested ex vivo in murine and human serum. Test protocol: Incubation of human and murine serum with corresponding dsRNA was done at 37°C. In each case, 85ul serum was incubated with 15 µl lOOuM dsRNA. After certain incubation spans (30 minutes, 1 hour, 2 hours, 4 hours, 8 hours, 12 hours, 24 hours) the samples were frozen at -80°C DsRNA without serum (+85 µl ddH2O) and dsRNA with serum at Time 0 were used as controls. In order to isolate dsRNA from the incubate, which was done on ice, 400 ul 0.1% SDS was added to each incubate, and these then underwent phenol extraction: 500 µl phenol:chloroform:isoamyl alcohol (IAA, 25:24:1, Roti phenol, Roth, Karlsruhe) were added to each incubate, and then vortexed at the highest setting for 30 seconds (Vortex Genie-2, Scientific Industries). After incubation for 10 minutes on ice, phase separation was carried out by centrifugation at 12,000 xg at 4°C for 10 minutes (Sigma 3K30, Rotor 12131-H). The top aqueous phase (approximately.200 µl) was collected and then underwent digestion: first with DNase I and then with Proteinase K: 20 µl 10x DNase buffer (100 mM tris, pH 7.5, 25 mM MgC12,1 mM CaC12) and 10 U DNase I (D 7291, Sigma-Aldrich) were added incubated for 30 minutes at 37°C, then 6 U DNase I were again added, incubated for another 20 minutes at 37°C. Then 5ul Proteinase K (20 mg/ml, 04-1075, Peqlab, Germany) was added and incubated for 30 minutes at 37°C. Phenol extraction was then carried out. To this was added 500 µl phenol:chloroform:IAA (25:24:1), vortexed for 30 seconds at the highest setting, and then centrifuged for 10 minutes at 12,000 xg and 4°C. The supernatant fluid was drawn off and replaced sequentially with 40 µl 3 M Na-Ac (sodium acetate), pH 5.2, and 1 ml 100% EtOH; this was well mixed and precipitated for at least one hour at -80°C. The precipitate was pelleted by centrifugation at 12,000 xg for 30 minutes at 4°C, washed with 70% EtOH, and again centrifuged (10 minutes, 12,000 xg at 4°C). The air-dried pellet was then mixed in 30 µl RNA gel application buffer (7 M urea, 1 x TBE [0.09 M tris borate, 0.002 M EDTA, 0.02% [w/v] bromophenol blue, 0.2% [w/v] xylencyanol) and stored at -20°C until gel application. In order to characterize the dsRNA, analytic, denaturing polyacrylamide gel electrophoresis (analytic PAGE) was carried out. The urea gels were produced shortly before the run: 7M urea (21 g) was dissolved while stirring in 25 ml 40% aqueous acrylamide/bisacrylamide solution (Rotiphoresis gel, A515.1, Roth) and 5 ml 10 x TBE (108 g tris, 55 g boric acid, 3.9 g EDTA per liter distilled water) and diluted to 50 ml with of distilled water. Shortly before pouring, 50 µl TEMED (N,N,N',N'-tetramethyl ethylendiamine) and 500 pi 10% APS (ammonium peroxide sulfate) were added. After polymerization, the gel was placed in a vertical electrophoresis apparatus (Merck, Darmstadt), and a first fraction was carried out for 30 minutes at a constant amperage of 40 mA. 1 x TBE buffer was used as the running buffer. Before applying them to the gel, the RNA samples were heated for 5 minutes at 100°C, cooled on ice, and then centrifuged for 20 seconds on a table centrifuge (Eppendorf Minispin). 15 ul of each sample was applied to the gel. The test run lasted for approximately two hours at a constant amperage of 40 mA. After the run, the gel was stained with Stains All staining solution (20 ml Stains All solution [200 mg Stains All dissolved in 200 ml formaldehyde] with 200 ml of distilled water and 100 ml formamide), and the background stain was then removed by rinsing with distilled water for 45 minutes. The gels were photographed using the Image Master VDS photodocumentation system from Pharmacia. Figures 10 to 17 show the serum stability of dsRNA after incubation with human or murine serum, and subsequent electrophoretic separation in 20% 7M urea gel. Figure 10: Incubation of SI (0-22-0) in mouse serum 1. At Time 0 (without serum) 2. At Time 0 3. For 30 minutes 4. For 1 hour 5. For 2 hours 6. For 4 hours 7. For 12 hours 8. 2 µl 100 µM SI without incubation SI A) sense strand SI (10 µl 20 µM S1A) SIB) antisense strand SI (10 µl 20 µM SIB) Figure 11: Incubation of SI (0-22-0) in human serum 1. 2 µl 100 µM SI untreated (without incubation) 2. For 30 minutes 3. For 2 hours 4. For 4 hours 5. For 6 hours 6. For 8 hours 7. For 12 hours 8. For 24 hours SI A) sense strand SI (10 ul 20 uM SI A) SIB) antisense strand SI (10 ul 20 uM SIB) Figure 12: Incubation of S7 (2-19-2) in mouse serum 1. At Time 0 (without serum) 2. For 30 minutes 3. For 4 hours 4. For 12 hours Figure 13: Incubation of S7 (2-19-2) in human serum 1. Sense strand S7 (10 µl 20 pM S7A) 2. Antisense strand S7 (10 µl 20 µM S7B) 3. For 30 minutes 4. For 1 hour 5. For 2 hours 6. For 4 hours 7. For 6 hours 8. For 12 hours 9. For 24 hours 10. At Time 0 (without serum) Figure 14: Incubation of K3 (2-19-2) in mouse serum 1. Sense strand K3 (10 µl 20 µM K3A) 2. Antisense strand K3 (10 µl 20 µM K3B) 3. At Time 0 (without serum) 4. At Time 0 (with serum) 5. For 30 minutes 6. For 1 hour 7. For 2 hours 8. For 4 hours 9. For 12 hours Figure 15: Incubation of PKC1/2 (0-22-2) in mouse serum 1. For 30 minutes 2. For 1 hour 3. For 2 hours 4. For 4 hours 5. For 12 hours 6. 2 ul lOOuM PKC1/2 (untreated) Figure 16: Incubation of S1A/S4B (0-22-2) in human serum 1. At Time 0 (without serum) 2. For 24 hours 3. For 12 hours 4. For 8 hours 5. For 6 hours 6. For 4 hours 7. For 2 hours 8. For 30 minutes 9. Sense strand SI A (10 µl 20 µM SI A) 10. Antisense strand S4B (10 µl 20 µM S4B) Figure 17: Incubation of K2 (2-22-2) in human serum 1. Sense strand K2 (10 µl 20 µM K2A) 2. Antisense strand K2 (10 µl 20 µM K2B) 3. At Time 0 (without serum) 4. For 30 minutes 5. For 2 hours 6. For 4 hours 7. For 6 hours 8. For 8 hours 9. For 12 hours 10. For 24 hours Results: DsRNAs without single-stranded regions at the 3'-ends are considerably more stable in both human and mouse serum than are dsRNAs with single-stranded 2nt overhangs at the 3'-ends (Figures 10 to 14 and 17). After 12 and 24 hours, respectively, of incubation of SI in both murine and human serum, one band of the original size remains almost completely intact. By contrast, the stability of dsRNAs with 2nt overhangs at both 3'-ends decreases considerably in both human and murine serum. Even after only 4 hours of incubation of S7 (Figures 12 and 13) or K3 (Figure 14), no band of the original size is still detectable. In order to enhance the stability of dsRNA in serum, it is sufficient if the dsRNA possesses one smooth end. The original size of the band has hardly been broken down at all in mouse serum after 4 hours incubation (Figure 15, Track 4) when compared to S7 (complete decomposition after 4 hours; Figure 12, Track 3) One optimal compromise with regard to the biological effectiveness of dsRNA may be the use of dsRNA with one smooth end and one single-stranded region of 2 nucleotides, whereby the single-stranded overhang is located at the 3'-end of the antisense strand. The sequences used here are reproduced in the following Table 2 and in the sequence protocols SQ148-151 and 153-167. Name Sequence protocol No. dsRNA-Sequence SI SQ148 SQ149 (A) 5'- CCACAUGAAGCAGCACGACUUC -3' (B) 3'- GGUGUACUUCGUCGUGCUGAAG -5' 0-22-0 S7 SQ150 (A) 5'- CCACAUGAAGCAGCACGACUU -3' SQ151 (B) 3'- CUGGUGUACUUCGUCGUGCUG -5' 2-19-2 Kl SQ153 SQ154 (A) 5'- ACAGGAUGAGGAUCGUUUCGCA -3' (B) 3'- UGUCCU ACUCCU AGC A A AGCGU -5' 0-22-0 K3 SQ155 SQ156 (A) 5'-GAUGAGGAUCGUUUCGCAUGA-3' (B) 3'-UCCUACUCCUAGCAAAGCGUA-5' 2-19-2 K3 SQ155 SQ156 (A) 5'-GAUGAGGAUCGUUUCGCAUGA-3' (B) 3'-UCCUACUCCUAGCAAAGCGUA-5' 2-19-2 K2 SQ157 SQ158 (A) 5'- ACAGGAUGAGGAUCGUUUCGCAUG - 3' (B) 3'-UCUGUCCUACUCCUAGCAAAGCGU -5' 2-22-2 SIA/ S4B SQ148 SQ159 (A) 5'-CCACAUGAAGCAGCACGACUUC -3' (B) 3'-CUGGUGUACUUCGUCGUGCUGAAG -5' 0-22-2 PKC1/2 SQ160 SQ161 (A) 5'- CUUCUCCGCCUCACACCGCUGCAA -3' (B) 3-GAAGAGGCGGAGUGUGGCGACG -5' 2-22-0 S7/S12 SQ150 SQ162 (A) 5'- CCACAUGAAGCAGCACGACUU -3' (B) 3'- GGUGUACUUCGUCGUGCUGAA -5' 0-21-0 S7/S11 SQ150 SQ163 (A) 5'- CCACAUGAAGCAGCACGACUU -3' (B) 3'- CUGGUGUACUUCGUCGUGCUGAA -5' 0-21-2 S13 SQ164 SQ165 (A) 5'- CCACAUGAAGCAGCACGACU -3' (B) 3'- CUGGUGUACUUCGUCGUGCUGA -5' 0-20-2 S13/14 SQ164 SQ166 (A) 5'- CC AC AUG A AGCAGCACGACU -3' (B) 3'- GGUGUACUUCGUCGUGCUGA -5' 0-20-0 S4 SQ167 SQ159 (A) 5'- CC AC AUG A AGC AGC ACG ACUUCUU -3' (B) 3'-CUGGUGU ACUUCGUCGUGCUG A AG -5' 2-22-2 KIA/ K2B SQ153 SQ158 (A) 5'-ACAGGAUGAGGAUCGUUUCGCA -3' (B) 3'-UCUGUCCUACUCCUAGCAAAGCGU -5' 0-22-2 KIB/ K2A SQ154 SQ157 (A) 5'- ACAGGAUGAGGAUCGUUUCGCAUG - 3' (B) 3'- UGUCCU ACUCCU AGC A A AGCGU -5' 2-22-0 SIB/ S4A SQ149 SQ167 (A) 5'- CCACAUGAAGCAGCACGACUUCUU -3' (B) 3'-GGUGU ACUUCGUCGUGCUG A AG -5' 2-22-0 Table 2 IV. In vivo study: Double-stranded RNA (dsRNA) that was derived from the GFP sequence and nonspecific dsRNA, respectively, was injected into the caudal vein of "GFP lab mice" that express the green fluorescent protein (GFP) in all cells that are involved in protein biosynthesis. At the end of the experiment the animals were killed and tissue sections and plasma GFP expression were analyzed. Test protocol: dsRNA synthesis: The individual RNA strands seen in the sequence protocols as well as their complementary individual strands were synthesized using an RNA synthesizer (Expedite 8909, Applied Biosystems, Weiterstadt, Germany), as well as by conventional chemical means. Purification of the raw synthesis products was then done with the help of the HPLC. The NucleoPac PA-100, 9 x 250 column (Dionex) was used: 20 mM tris, 10 mM NaC104, pH 6.8, 10% acetonitrile was used as the low salt buffer, and 20 mM tris, 400 mM NaClO^ pH 6.8,10% acetonitrile was used as the high salt buffer. Flow was 3 ml per minute. Hybridization of the individual strands into a double-stranded was done by heating the stochiometric mixture of the individual strands in 10 mM sodium phosphate buffer, pH 6.8,100 mM NaCl to 80-90°C and then allowing it to cool slowly over 6 hours to room temperature. Test-animal conditions and course of the experiment: The transgenic laboratory mouse strain TgN(GFPU)5Nagy (Jackson Laboratory, Bar Harbor, ME) was used; this strain has been shown to express GFP (with a beta-actin promoter and a CMV intermediate early enhancer) in all previously tested cells, (Hadjantonakis AK et al., 1993, Mech Dev. 76:79-90; Hadjantonakis AK et al., 1998, Nature Genetics 19: 220-222). The GFP-transgenic mice may be readily differentiated from the corresponding wild type (WT) on the basis of fluorescence (using a hand¬held UV lamp). The corresponding WT was always paired with a heterozygote GFP type for purposes of breeding. The experiment was conducted in accordance with the German animal rights laws. The animals were kept in a controlled environment in groups of 3-5 animals in Type III Makrolon cages (Ehret, Emmendingen) at a constant temperature of 22°C and a day/night rhythm of 12 hours. Wood shavings of 8/15 granulated softwood (Altomin, Lage) were used. The animals received tap water and standard feed (Altormin 1324 pellets) ad libitum. The heterozygote GFP animals that were used in the experiment were kept in cages in groups of 3 animals as described above. Injection of dsRNA solution was done intravenously (i.v.) in the caudal vein in 12-hour cycles (between 5:30 and 7:00 and between 17:30 and 19:00) over a 5-day period. Injection volume was 60 µl per 10 g of body weight, and the dosage was 2.5 mg dsRNA or 50 ug, respectively, per kg body weight. The groups were divided as follows: Group A: PBS (phosphate buffered saline) 60 pi per 10 g body weight each, Group B: 2.5 mg per kg body weight of a nonspecific control dsRNA (Kl control with smooth ends and a double-stranded region consisting of 22 nucleotide pairs), Group C: 2.5 mg per kg body weight of another nonspecific control dsRNA (K3 control with 2nt overhangs at both 3'-ends and a double-stranded region consisting of 19 nucleotide pairs), Group D: 2.5 mg per kg body weight dsRNA (specific anti-GFP directed, henceforth referred to as SI, with smooth ends and a double-stranded region consisting of 22 nucleotide pairs), Group E: 2.5 mg dsRNA per kg body weight (specific anti-GFP, henceforth referred to as S7, with 2nt overhangs at the 3'-ends of both strands and a double strand region consisting of 19 nucleotide pairs), Group F: 50 pg SI dsRNA per kg body weight (in other words 1/50 of the dosage in Group D). After the last of a total of 10 injections, the animals were killed after 14-20 hours, and the organs and blood were removed as described. Organ removal: Immediately after the animals were killed by means of CO2 inhalation, their blood and various organs were removed (thymus, along, heart, spleen, stomach, intestines, pancreas, brain, kidneys, and liver). The organs were quickly rinsed with cold, sterile PBS and sectioned using a sterile scalpel. One portion was fixed for 24 hours in methyl carnoys (MC, 60% methanol, 30% chloroform, 10% glacial acetic acid) for immunohistochemical staining; one portion was immediately flash-frozen in liquid nitrogen and stored at -80°C for making frozen sections and for protein isolation; and another, smaller portion, was frozen in RNAeasy Protect (Qiagen) at-80°C for RNA isolation. Immediately after removal, the blood was placed on the ice for 30 minutes, mixed, and centrifuged for 5 minutes at 2000 rpm (Mini spin, Eppendorf). The supernatant fluid (here referred to as plasma) was drawn off and stored at ~80°C Processing the biopsies: After the tissues had been fixed for 24 hours in MC, the tissue pieces were dehydrated in an ascending alcohol series at room temperature: 40 minutes each, 70% methanol, 80% methanol, 2 x 96% methanol and 3 x 100% isopropanol. After that, the tissue was warmed in an incubator in 100% isopropanol at 60°C, after which it was incubated for one hour in an isopropanol/ paraffin mixture at 60°C and 3x for 2 hours in paraffin, and then bedded in paraffin. For the immunoperoxidase stains, the tissue sections 3 µm in thickness were prepared, using a rotation microtome (Leica), placed on glass slides (Superfrost, Vogel) and incubated for 30 minutes in an incubator at 60°C. Immunoperoxidase staining for GFP: The sections were deparaffinized 3x5 minutes in xylol, rehydrated in a descending alcohol series (3x3 min., 100% ethanol, 2x2 min. 95% ethanol), and then incubated in 3% H2C»2/methanol to block endogenous peroxidases. All incubation steps in the following were carried out in a moist chamber. After washing with PBS 3x3 minutes, incubation was carried out with the first antibody (goat anti-GFP, sc-5384, Santa Cruz Biotechnology) 1:500 in 1% BSA/PBS overnight at 4°C. Incubation with the biotinylated secondary antibody (donkey anti-goat; Santa Cruz Biotechnology; dilution 1:2000) was then carried out for 30 minutes at room temperature, after which it was incubated with Avidin D peroxidase (dilution 1:2000, Vector Laboratories). After each antibody incubation, the sections were washed in PBS for 3 x 3 minutes, and the buffer residue and cell debris were removed from the sections. All antibodies were diluted in 1% bovine serum albumin (BSA)/PBS. Staining with 3,3'- diaminobenzadine (DAB) was done using a DAB substrate kit (Vector Laboratories) in accordance with manufacturer instructions. Gill's Hematoxylin III was used for the nucleic counter stain (Merck). After dehydration in an ascending alcohol series and 3 x 5 minutes xylol, the sections were covered with Entellan (Merck). Microscopic analysis of the stains was done using an Olympus 1X50 microscope fitted with a CCD camera (Hamamatsu). Protein isolation from tissue pieces: 800 ul isolation buffer (50mM HEPES, pH 7.5; 150 mM NaCl; 1 mM EDTA; 2.5 mM EGTA; 10% glycerol; 0.1% Tween; 1 mM DDT; 10 mM B-glycerol phosphate; 1 mM NaF; O.lmM Na3VCO4 with a "Complete" protease inhibitor tablet manufactured by Roche) was added to each of the still-frozen tissue pieces, and then homogenized 2 x 30 seconds using an Ultraturrax (DIAX 900, 6G disperser, Heidolph), and cooled on ice between homogenization steps. After incubation on ice for 30 minutes, it was mixed and centrifuged for 20 minutes at 10,000 xg, at 4°C (3K30, Sigma). The supernatant fluid was then again incubated on ice for 10 minutes, mixed, and centrifuged for 20 minutes at 15,000 xg. Protein determination was then done on the supernatant fluid according to Bradford, 1976, modified according to Zor & Selinger, 1996, using the Roti-Nanoquant system from Roth, in accordance with the manufacturer instructions. BSA (bovine serum albumin) was used for protein calibration at concentrations ranging from 10 to 100 µg/ml. SDS gel electrophoresis: Electrophoretic separation of the proteins was done in a Multigel-Long electrophoresis chamber from Biometra with a denaturing, discontinuous 15% SDS-PAGE (polyacrylamide gel electrophoresis) according to Lammli (Nature 277: 680-685, 1970). On top of this was poured a separation gel to a thickness of 1.5 mm: 7.5 ml acrylamide/bisacrylamide (30%, 0.9%), 3.8 ml 1.5 M tris/HCl, pH 8.4,150 µl 10% SDS, 3.3 ml bidistilled water, 250 µl ammonium persulfate [10%], 9 µl TEMED (N,N,N',N'-tetramethylendiamine) and layered with 0.1% SDS until polymerization occurred. Then the collection gel was poured: 0.83 µl acrylamide/bisacrylamide (30%/0.9%), 630 µl 1 M tris/HCl, pH 6.8, 3.3 ml bidistilled water, 50 µl 10% SDS, 50 µl 10% ammonium persulfate, 5 µl TEMED. Before being applied to the gel, a corresponding quantity of 4x sample buffer (200 mM tris, pH 6.8, 4% SDS, 100 mM DTT [dithiotreithol], 0.02% bromphenol blue, 20% glycerin) was added to the proteins, and denatured on a heat block at 100°C. After cooling off on ice, this was quickly centrifuged and applied to the gel. The same amounts of plasma or protein were used for each track (3 µl plasma or 25 pg total protein). Hydro-cooled electrophoresis was done at room temperature and at a constant 50 V. The protein gel marker from BioRad (Kaleidoscope Pre-stained Standard) was used as the standard length. Western blot and Immunodetection: Transfer of the proteins from SDS-PAGE to a PVDF (polyvinyl difluoride) membrane (Hybond-P, Amersham) was done using a semidry method according to Kyhse-Anderson (J. Biochem. Biophys. Methods 10:203-210,1984) at room temperature and a constant amperage of 0.8 mA/cm2 for 1.5 hours. A tris/glycine buffer (39 mM Gly, 46 mM tris, 0.1% SDS, and 20% methanol) was used as the transfer buffer. In order to analyze electrophoretic transfer, both the post-blot gels and the blot membranes were stained after immunodetection using Coomassie (0.1% Coomassie G250, 45% methanol, 10% glacial acetic acid). The blot membrane was incubated after transfer in 1% skim milk powder/PBS for one hour at room temperature in order to saturate nonspecific bonds. After that, it was washed three times for 3 minutes with 0.1% Tween-20/PBS. All subsequent antibody incubations and washings were done using 0.1% Tween-20/PBS. Incubation with the primary antibody (goat anti-GFP, sc-5384, Santa Cruz Biotechnology) was done at a dilution of 1:1000 for 1 hour at room temperature. After that, it was washed 3x5 minutes , labeled with the secondary antibody (donkey anti-goat IgG horseradish peroxidase, Santa Cruz Biotechnology) for 1 hour at room temperature at a dilution of 1:10,000. Detection was then done using the ECL system from Amersham in accordance with the manufacturer instructions. Figures 18 to 20 show on, 3-um paraffin sections, the inhibition of GFP expression after intravenous injection of specific anti-GFP directed dsRNA with anti-GFP immunoperoxidase stain. In the test run, anti-GFP directed dsRNA with a double-stranded region consisting of 22 nucleotide pairs without overhangs at the 3'-ends (D) and the corresponding nonspecific control dsRNA (B), as well as the specific anti-GFP directed dsRNA with a double-stranded region comprising 19 nucleotide pairs with 2nt overhangs at the 3'-ends (E) and the corresponding nonspecific control dsRNA (C) were applied in 12-hour rotations over 5 days. (F) received 1/50 of the dosage of Group D. Animals that received no dsRNA (A) and WT animals were also tested as a further control. Figure 18 shows the inhibition of GFP expression in kidney sections, Figure 19 in heart tissue sections, and Figure 20 in pancreas tissue. Western blot analyses of GFP expression in plasma and tissue are shown in Figures 21 to 23. Figure 21 shows the inhibition of GFP expression in plasma; Figure 22 in kidney tissue, and Figure 23 in heart tissue. The application of total protein isolates from various animals is shown in Figure 23. The same amounts of total protein were applied to each track. In the animals that received nonspecific control dsRNA (animals in Groups B and C), GFP expression was not reduced in comparison to animals that received no dsRNA whatsoever. Animals that received specific anti-GFP directed dsRNA that contained 2nt overhangs at the 3'-ends of both strands and a double-stranded region consisting of 19 nucleotide pairs showed significant inhibition of GFP expression in the tissues examined (heart, kidneys, pancreas, and blood), compared with untreated animals (Figures 18 to 23). In animals in Groups D and F that were given specific anti-GFP directed dsRNA with smooth ends and a double-stranded region comprising 22 nucleotide pairs, only those animals that received the dsRNA in a dosage of 50 ug/kg body weight per day exhibited a specific inhibition of GFP expression, which, however, was less marked than in the animals in Group E. Summary analysis of GFP inhibition in tissue sections and on Western blot show that inhibition of GFP expression is strongest in the blood and kidneys (Figures 18, 21, and 22). V. Inhibition of gene expression of the EGF receptor with dsRNA as a therapeutic approach to forms of cancer characterized by EGFR overexpression or EGFR-induced proliferation: The epidermal growth factor (=EGF) receptor (=EGFR) belongs to the tyrosin kinase receptors, transmembrane proteins with an intrinsic tyrosin kinase activity that are involved in the control of a series of cellular processes such as cell growth, cell differentiation, migratory processes, and cell vitality (overview in: Van der Geer et al., 1994). The EGFR family consists of 4 members, EGFR (ErbBl), HER2 (ErbB2), HER3 (ErbB3), and HER4 (ErbB4) with a transmembrane domain, a cystein-rich extracellular domain, and a catalytic intracellular domain. The EGFR sequence, a 170-kDa protein, has been known since 1984 (Ullrich et al., 1984). EGFR is activated by peptide growth factors such as EGF, TGFa (transforming growth factor), amphiregulin, betacellulin, HB-EGF (heparin binding EGF-like growth factor), and neuregulins. Ligand binding induces the formation of homodimes or heterodimes with subsequent autophosphorylation of cytoplasmic tyrosine (Ullrich & Schlessinger, 1990; Alroy & Yarden, 1997). The phosphorylated amino acids form the binding sites of numerous proteins that are involved in the proximal stages of signal transmission in a complex network. EGFR is involved in the most varied tumoral diseases, and is therefore an appropriate target for therapeutic approaches (Huang & Harari, 1999). The mechanisms that lead to aberrant EGFR activity may be related to overexpression, amplification, constitutive activation of mutant receptor forms, or autocrine loops (Voldberg et al., 1997). Overexpression of EGFR has been described for a series of tumors such as breast cancer (Walker & Dearing, 1999), non-minor lung cancer (Fontaninii et al., 1998), pancreatic cancer, colon cancer (Salomon et al, 1995), and glioblastoma (Rieske et al., 1998). For malignant glioblastoma, in particular, there have to date been no effective and specific therapeutic agents. Example: To detect the effectiveness of dsRNA in the specific inhibition of EGFR gene expression, U-87 MG cells (human glioblastoma cells), ECCAC (European Collection of Animal Cell Culture) No. 89081402 was used, and was transfected with the specific anti-EGF-receptor-directed dsRNA (sequence protocol SQ 51). After approximately 72 hours of incubation, the cells were harvested, the protein was isolated, and EGFR expression was analyzed by Western blot. Test protocol: dsRNA synthesis: The individual RNA strands seen in the sequence protocols as well as their complementary individual strands were synthesized using an RNA synthesizer (Expedite 8909, Applied Biosystems, Weiterstadt, Germany), as well as by traditional chemical means. Purification of the raw synthesis products was then done with the help of the HPLC. The NucleoPac PA-100, 9 x 250 column (Dionex) was used with 20 mM tris; 10 mM NaC104, pH 6.8,10% acetonitrile was used as the low salt buffer, and 20 mM tris, 400 mM NaClCu, pH 6.8, 10% acetonitrile were used as the high salt buffer. Flow was 3 ml per minute. Hybridization of the individual strands into a double-stranded was done by heating the stochiometric mixture of the individual strands in 10 mM sodium phosphate buffer, pH 6.8,100 mM NaCl to 80-90°C and then allowing them to cool slowly over 6 hours to room temperature. Seeding the cells: All cell culturing was done under sterile conditions at an appropriate workstation (HS18/ Hera Safe, Kendro, Heraeus). Culturing of the U-87 MG cells was done in the incubator (CCb-incubator T20, Hera Cell, Kendro, Heraeus) at 37°C, 5% CO2 and saturated atmospheric humidity in DMEM (Dulbecco's modified eagle medium, Biochrom) with 10% FCS (fetal calf serum, Biochrom), 2 mM L-glutamine (Biochromone) mM sodium pyruvate (Biochrom), 1 x NEAA (nonessential amino acids, Biochrom), and penicillin/streptomycin (100 IU/100µg/ml, Biochrom). In order to maintain the cells in an exponential growth state, the cells were passaged every 3 days. 24 hours before dsRNA application by means of transfection, the cells were trypsinized (10 x trypsin/EDTA, Biochrom, Germany) and placed in a 6-well plate (6-well plates, Schubert & Weiss Laboratories, GmbH) in 1.5 µl growth medium. DsRNA application in cultured U-87 MG cells: Application of dsRNA was done by means of transfection using the OLIGOFECTAMINE™ reagent (Life Technologies) in accordance with the manufacturer instructions. Total transfection volume was 1 ml. First, the dsRNA was diluted in serum-free medium: 0.5ul of a 20 uM stock solution of specific anti-EGFR directed dsRNA and 9.5 ul of a 20 uM stock solution of nonspecific dsRNA (K1A/K2B) diluted with 175 µl serum-free medium (200 nM dsRNA in the transfection incubate or 10 nM specific EGFR-dsRNA) per well. The OLIGOFECTAMINE™ reagent was also diluted in serum-free medium: 3 µl with 12 µl medium per well and then incubated for 10 minutes at room temperature. Then the diluted OLIGOFECTAMINE™ reagent was added to the medium of diluted dsRNA, mixed, and incubated for another 20 minutes at room temperature. The medium was changed during incubation. The cells were washed 1 x with 1 ml serum-free medium and continued to be incubated in the incubator with 800 pi serum-free medium until the dsRNA/OLIGOFECTAMINE™ reagent was added. After the addition of 200 pi dsRNA/OLIGOFECTAMINE™ reagent per well, the cells continued to be incubated in the incubator until protein isolation. Protein isolation: Approximately 72 hours after transfection, the cells were harvested and the protein was isolated. The medium was removed, and the cell monolayer was washed once with PBS. After the addition of 200 pi protein isolation buffer (lx "Complete" protease inhibitor, Roche, 50 mM HEPES, pH 7.5,150 mM NaCl, 1 mM EDTA, 2.5 mM EGTA, 10% glycerin, 0.1% Tween-20,1 mM DTT, 10 mM p-glycerine phosphate, 1 mM NaF, 0.1 mM Na3V04) the cells were removed with the help of a cell scraper, incubated for 10 minutes on ice, transferred to an Eppendorf reagent vessel, and stored at -80°C for at least 30 minutes. After thawing, the lysate was homogenized at the third setting for 10 seconds with a disperser (DIAX 900, 6G disperser, Heidolph Instruments GmbH, Schwabach), incubated on ice for 10 minutes, and then centrifuged for 15 minutes at 14,000 xg at 4°C (3K30, Sigma). Protein determination according to Bradford was done on the supernatant fluid using the Roti-Nanoquant system from Roth (Roth GmbH, Karlsruhe) in accordance with the manufacturer's instructions. 200 pi protein solution at a suitable dilution is mixed with 800 pi lx working solution, and extinction was measured in semi-microcuvettes at 450 ran and 590 ran against distilled water in a Beckman spectrophotometer (DU 250). BSA dilutions were used for calibration (beaded BSA, Sigma). SDS gel electrophoresis: Electrophoretic separation of the proteins was done in a Multigel-Long electrophoresis chamber from Biometra with a denaturing, discontinuous 7.5% SDS-PAGE (polyacrylamide gel electrophoresis) according to Lammli (Nature 277: 680-685, 1970). Orv top of this was poured a separation gel to a thickness of 1.5 mm-. 3.75 ml acrylamide/bisacrylamide (30%, 0.9%), 3.8 ml 1 M tris/HCl, pH 8.4,150 pi 10% SDS, 7.15 ml distilled water, 150 µl ammonium persulfate (10%), 9 µl TEMED (N,N,N',N'-tetramethylendiamine) and layered with 0.1 percent SDS until polymerization occurred. After that, the collection gel was poured: 0.83 ml acrylamide/bisacrylamide (30%/0.9%), 630 µl 1 M tris/HCl, pH 6.8, 3.4 ml distilled water, 50 µl 10% SDS, 50 µl 10% ammonium persulfate, 5 µl TEMED. Before being applied to the gel, a quantity of 4x sample buffer (200 mM tris, pH 6.8, 4% SDS, 100 mM DTT [dithiotreithol], 0.02% bromphenol blue, 20% glycerin) was added to the proteins in a 1:3 ratio, and denatured at 100°C for 5 minutes. After cooling off on ice, this was quickly centrifuged and applied to the gel. The same amount of protein was used for each track (35 pg total protein). The hydro-cooled gel run was done at room temperature and at a constant 50 V. Kaleidoscope Prestained Standard (BioRad) was used as the standard length. Western blot and Immunodetection: I Transfer of the proteins from SDS-PAGE to a PVDF (polyvinyl difluoride) membrane (Hybond-P, Amersham) was done using a semidry method according to Kyhse-Anderson (J. Biochem. Biophys. Methods 10:203-210,1984) at room temperature and a constant 0.5 mA/cm2 for 1.5 hours. A cathode buffer (30 mM tris, 40 mM glycine, 10% methanol, and 0.01% SDS, pH 9.4), anode buffer I (300 mM tris, pH 10.4, 10% methanol), and anode buffer II (30 mM tris, pH 10.4,10% methanol) were used as the transfer buffers. Before assembling the blot stack with 3MM Whatman paper (Schleicher & Schiill) the gel was incubated in cathode buffer, and the PVDF membrane (previously for 30 seconds in 100% methanol) in anode buffer II (5 minutes): 2 layers of 3MM paper (anode buffer I), 1 layer 3MM paper (anode buffer II), PVDF membrane, gel, 3 layers 3MM paper (cathode buffer). To analyze electrophoretic transfer, both the post-blot gels and the blot membranes were stained after immunodetection using Coomassie (0.1% Coomassie G250, 45% methanol, 10% glacial acetic acid). After transfer, the blot membrane was incubated in 1% skim milk powder/PBS/0.1% Tween-20 for one hour at room temperature. After that, it was washed three times for 3 minutes with 0.1% Tween-20/PBS. All subsequent antibody incubations and washings were done using 0.1% Tween-20/PBS. Incubation with the primary antibody (human EGFR extracellular domain, specific goat IgG, Catalogue No. AF231, R&D Systems) was done on a shaker for two hours at room temperature at a concentration of 1.5 µg/ml. After that it was washed 3x5 minutes and incubated for one hour at room temperature with the secondary antibody (labeled donkey anti-goat IgG horseradish peroxidase, Santa Cruz Biotechnology) at a dilution of 1:10,000. After washing (3x3 minutes in PBS/0.1% Tween-20) detection was immediately done by means of ECL reaction (enhanced chemoluminescence). To 18 ml of distilled water was pipetted 200 ul Solution A (250 mM luminol, Roth, dissolved in DMSO), 89 ul Solution B (90 mM p-coumaric acid, Sigma, dissolved in DMSO), and 2 ml 30% H2O2 solution. Depending on membrane size, 4-6 ml was pipetted directly onto the membrane, incubated for 1 minute at room temperature, and then layed immediately on x-ray film (Biomax MS, Kodak). The sequences used here are contained in Table 3 below, as well as in sequence protocols SQ153,157,158,168-173. ES-7 SQ168 SQ169 (A) 5'- A AC ACCGC AGC AUGUC A AG AU -3' (B) 3'- UUUUGUGGCGUCGUACAGUUC -5' 2-19-2 ES-8 SQ170 SQ171 (A) 5'- AAGUUAAAAUUCCCGUCGCUAU -3' (B) 3'- CAAUUUUAAGGGCAGCGAUAGU -5' 25-19-25 ES2A/ ES5B SQ172 SQ173 (A) 5'- AGUGUG AUCC A AGCUGUCCC A A -3' (B) 3'- UUUCACACUAGGUUCGACAGGGUU -5' 0-22-2 K2 SQ157 SQ158 (A) 5'- ACAGGAUGAGGAUCGUUUCGCAUG -3' (B) 3'- UCUGUCCUACUCCUAGCAAAGCGU -5' 2-22-2 KIA/ K2B SQ153 SQ158 (A) 5'-ACAGGAUGAGGAUCGUUUCGCA -3' (B) 3'-UCUGUCCUACUCCUAGCAAAGCGU -5' 0-22-2 Table 3 Inhibition of EGFR expression in U-87 MG glioblastoma cells: 24 hours after seeding the cells, they were transfected with 10 nM dsRNA as noted (oligofectamine). After 72 hours, the cells were harvested and the proteins isolated. Separation of the proteins was done in 7.5% SDS-PAGE. 35 µg total protein was applied to each track. The corresponding Western blot analysis may be seen in Figure 24, which shows that with the specific anti-EGFR-directed dsRNA with a 2nt overhang at the 3'-end of the antisense strand, EGFR expression after transfection in U-87 MG cells is significantly inhibited in comparison to the corresponding controls. This inhibition of expression of an endogenous gene by means of specific dsRNA confirms the results noted in Example II, of the inhibition of the expression of an artificial gene inserted into the cell after transient transfection. The inhibition of EGFR expression mediated by ES-7 and ES-8 is notably smaller. The dsRNAs used in Figure 24 are shown in Table 3. VI. Inhibiting expression of multi-drug resistance gene 1 (MDR1): Test protocol: In vitro detection of the blocking of MDR1 expression was done using the colon cancer cell line LS174T (ATCC - American Type Culture Collection; Tom et al., 1976). It is known of this cell line that expression of MDR1 is inducible by adding rifampicin to the culture medium (Geick et al., 2001). Transfection was done using a variety of commercially available transfection kits (Lipofectamine, Oligofectamine, both from Invitrogen; TransMessenger, Qiagen), of which the TransMessenger kit proved to be the most suitable for this cell line. Four short double-stranded ribonucleic acids (R1-R4) were used to conduct the RNA interference experiments. Their sequences are shown in Table 4. The ribonucleic acids are homologous with segments of the coding sequence of MDR1 (sequence protocol SQ 30). Sequences R1-R3 consist of a 22-mer sense strand and a 24-mer antisense strand, whereby the resulting double strand exhibits a 2-nucleotide overhang at its 3'-end (0-22-2). Sequence R4 corresponds to Rl; however it consists of a 19-mer double-stranded, each with 2-nucleotide overhangs at each 3'-end (2-19-2). Name Sequence protocol No. Sequence Position in Data bank- # AF016535 SeqRl SQ141 SQ142 5'- CCA UCU CGA AAA GAA GUU AAG A-3' 3'-UG GGU AGA GCU UUU CUU CAA UUC U-5' 1320-1342 1335-1318 SeqR2 SQ143 SQ152 5'- UAU AGG UUC CAG GCU UGC UGU A-3' 3'-CG AUA UCC AAG GUC CGA ACG ACA U-5' 2599-2621 2621-2597 SeqR3 SQ144 SQ145 5'- CCA GAG AAG GCC GCA CCU GCA U-3' 3'-UC GGU CUC UUC CGG CGU GGA CGU A-5' 3778-3799 3799-3776 SeqR4 SQ146 SQ147 5'- CCA UCU CGA AAA GAA GUU AAG-3' 3'-UG GGU AGA GCU UUU CUU CAA U -5' 1320-1341 1339-1318 Position in Data bank- # AF402779 KIA/ K2B SQ153 SQ158 5'- ACA GGA UGA GGA UCG UUU CGC A-3' 3'-UC UGU CCU ACU CCU AGC AAA GCG U-5' 2829-2808 2808-2831 Table 4 The sequences shown in Table 4 are designated as sequences SQ141-147,152,153, and 158 in the sequence protocol. The dsRNA was in each case transfected into the cells as double assays at a concentration of 175 nM, which had on the day before been seeded in 12-well plates at 3.8 x 105 cells/well. For each transfection assay, 93.3 pi EC-R buffer (TransMessenger kits, Qiagen, Hilden) was mixed with 3.2 pi Enhancer R, and then 3.5 pi of the particular 20 pM dsRNA was added, mixed well, and incubated for 5 minutes at room temperature. After the addition of 6pl TransMessenger transfection reagent, the transfection assay was mixed vigorously for 10 seconds, and then incubated for 10 minutes at room temperature. In the meantime, the medium was extracted from the cells, washed once with PBS (phosphate-buffered saline), and then 200 µl fresh medium without FCS was added to the cells in each well. After 10-minute incubation, 100 µl FCS-free medium was pipetted into each transfection assay, mixed, and the mixture was then pipetted drop by drop onto the cells (the dsRNA concentration of 175 µM relates to 400 medium total volume). The dsRNA/TransMessenger complexes were incubated with the cells for 4 hours at 37°C in FCS-free medium. The medium was then changed; the fresh medium contained 10 pM rifampin and 10% FCS. A non-specific dsRNA sequence that exhibits no homologies with the MDR1 gene sequence was used (K) as a control, and a MOCK transfection was conducted that contained all reagents except for dsRNA. The cells were harvested after 24, 48, and 72 hours, and total RNA was extracted with the RNeasy mini kit from Qiagen. 10 ug total protein from each sample was then separated by electrophoresis on a 1% agarose-formaldehyde gel, blotted on a nylon membrane, and then hybridized as an internal control with specific probes that had been random-marked with 5'-a32p-dCTP, first against MDR1, and after the blot had been stripped, against GAPDH, and then exposed on x-ray film. The x-ray film was digitized (Image Master, VDS, Pharmacia) and quantified using Image-Quant software. At that time, adjustment between the MDRl-specific bands and the corresponding GAPDH bands was done. Results: Figs. 25 and 26 show Northern blots (Figs. 26a, 26a) with quantitative analysis of the MDRl-specific bands after adjustment with the corresponding GAPDH values (Figs. 25b, 26p). A reduction in the MDRl-mRNA by as much as 55% was observed in comparison to the MOCK transfection, and by as much as 45% in comparison to the non-specific control transfection. After 48 hours there was a significant reduction in the MDRl-mRNA level in the dsRNA constructs designated as Rl, R2, and R3 (Table 4). With the R4 dsRNA constructs, no significant reduction in comparison to the controls was observed after 48 hours (Figs. 26a and 26b). After 74 hours, there was a markedly stronger reduction in the MDRl-mRNA level with Rl, R2, and R3 with the controls in comparison to the values at 48 hours (Figs. 25a and 26b). A significant decrease in the MDRl-mRNA level was seen at this time with R4 as well. Thus, the constructs with a 2nt overhang at the 3'-end of the antisense strand and a double-stranded region consisting of 22 nucleotide pairs reduces the MDRl-mRNA level more efficiently than do constructs with 2nt overhangs at the 3'-end of both strands (antisense strand and sent strand) and a double-stranded region consisting of 19 nucleotide pairs, relatively independent of the sequence region homologous to the MDR1 gene in each case (after 48 hours; Figure 26b). The results strengthen the findings in Example IV, which describe the inhibition of EGFR gene expression by means of specific dsRNAs after transfection in U-87 MG cells. Transfection efficiency was determined in a separate experiment with the help of a DNA oligonucleotide marked with Texas red (TexRed-A[GATC]sT; also transfected with 175 nM) (Figs. 27a, 27b; 400x enlargement, 48 hours after transfection). Transfection efficiency was approximately 50% on the basis of red fluorescent cells in comparison to total cell number. If one takes the transfection rate of cells of approximately 50% into consideration, then it seems reasonable to conclude that given the observed decrease in the MDRl-mRNA level by approximately 45-55% (compared with the controls), that MDRl-mRNA was almost completely and specifically broken down in all cells that were successfully transfected with specific dsRNA. Literature: Alroy I & Yarden Y (1997): The Erb signalling network in embryogenesis and oncogenesis: signal deversification through combinatorial ligand-receptor interactions. FEBS Letters 410: 83-86. Bass,B.L., 2000. Double-stranded RNA as a template for gene silencing. Cell 101, 235-238. BosherJ.M. and Labouesse,M., 2000. RNA interference: genetic wand and genetic watchdog. Nature Cell Biology 2, E31-E36. Bradford MM (1976): Rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248-254. Caplen,N.J-, FleenorJ., Fire,A., and Morgan,R.A., 2000. dsRNA-mediated gene silencing in cultured Drosophila cells: a tissue culture model for the analysis of RNA interference. Gene 252, 95-105. ClemensJ.C, Worby,CA„ Simonson-Leff,N., Muda,M., Maehama,T., Hemmings,B.A., and DixonJ.E., 2000. Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways. Proc.Natl.Acad.Sci.USA 97, 6499-6503. Cobleigh MA, Vogel CL, Tripathy D, Robert NJ, Scholl S, Fehrenbacher L, Wolter JM, Paton V, Shak S, Liebermann G & Slamon DJ (1999): Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. Journal of Clinical Oncology 17: 2639-2648. Ding,S.W., 2000. RNA silencing. Curr. Opin. Biotechnol. 11,152-156. Fire,A., Xu,S., Montgomery,M.K., Kostas,S.A., Driver,S.E., and Mello,C.C., 1998. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391, 806-811. Fire,A., 1999. RNA-triggered gene silencing. Trends Genet. 15, 358-363. Freier,S.M., Kierzek,R., JaegerJ.A., Sugimoto,N., Caruthers,M.H., Neilson/L, and Turner,D.H., 1986. Improved free-energy parameters for prediction of RNA duplex stability. Proc. Natl. Acad. Sci. USA 83, 9373-9377 . Geick, A., Eichelbaum, M„ Burk, O. (2001). Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J. Biol. Chem. 276 (18), 14581-14587. Fontanini G, De Laurentiis M, Vignati S, Chine S, Lucchi M, Silvestri V, Mussi A, Ue Placido S, Tortora G, Bianco AR, Gullick W, Angeletti CA, Bevilaqua G & Ciardiello F (1998): Evaluation of epidermal growth factor-related growth factors and receptors and of neoangiogenesis in completely resected stage I-IIIA non-small-cell lung cancer: amphiregulin and microvessel count are independent prognostic factors of survival. Clinical Cancer Research 4: 241-249. Hammond,S.M., Bernstein,E., Beach,D., and Hannon,GJ., 2000. An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature 404, 293-296. Higgins, C.F. (1995). The ABC of channel regulation. Cell, 82, 693-696. Hadjantonakis AK, Gertsenstein M, Ikawa M, Okabe M & Nagy A (1993): Generating green fluorescent mice by germline transmission of green fluorescent ES cells. Mech. Dev. 76: 79-90. Hadjantonakis AK, Gertsenstein M, Ikawa M, Okabe M & Nagy A (1998): Non¬invasive sexing of preimplantation mammalian embryos. Nature Genetics 19: 220-222. Kyhse-Anderson J (1984): Electroblotting of multiple gels: A simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose. J. Biochem. Biophys. Methods 10: 203-210. Lammli UK (1970): Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 277: 680-685. Loo, T.W., and Clarke, D.M. (1999) Biochem. Cell Biol. 77,11-23. Huang SM & Harari PM (1999): Epidermal growth factor receptor inhibition in cancer therapy: biology, rationale and preliminary clinical results. Investigational New Drugs 17: 259-269. Limmer,S., Hofmann,H.-P., Ott,G., and Sprinzl,M., 1993. The 3'-terminal end (NCCA) of tRNA determines the structure and stability of the aminoacyl acceptor stem. Proc. Natl. Acad. Sci. USA 90, 6199-6202. Montgomery,M.K. and Fire,A., 1998. Double-stranded RNA as a mediator in sequence-specific genetic silencing and co-suppression. Trends Genet. 14, 255-258. Montgomery,M.K., Xu,S., and Fire,A., 1998. RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 95, 15502-15507. Rieske P, Kordek R, Bartkowiak J, Debiec-Rychter M, Bienhat W & Liberski PP (1998): A comparative study of epidermal growth factor (EGFR) and mdm2 gene amplification and protein immunoreactivity in human glioblastomas. Polish Journal of Pathology 49:145-149. Robert, J. (1999). Multidrug resistance in oncology: diagnostic and therapeutic approaches. Europ J Clin Invest 29, 536-545. Stavrovskaya, A.A. (2000) Biochemistry (Moscow) 65 (1), 95-106. Salomon DS, Brandt R, Ciardiello F & Normanno N (1995): Epidermal growth factor related peptides and their receptors in human malignancies: Critical Reviews in Oncology and Haematology 19:183-232. Tom, B.H., Rutzky, L.P., Jakstys, M.M., Oyasu, R., Kaye, C.I., Kahan, B.D. (1976), In vitro, 12,180-191. Tsuruo, T., Iida, H., Tsukagoshi, S„ Sakurai, Y. (1981). Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil. Cancer Res, 41,1967-72. Ui-Tei,K., Zenno,S., Miyata,Y., and Saigo,K., 2000. Sensitive assay of RNA interference in Drosophila and Chinese hamster cultured cells using firefly luciferase gene as target. FEBS Lett. 479, 79-82. Ullrich A, Coussens L, Hayflick JS, Dull TJ, Gray A, Tarn AW, Lee J, Yarden Y, Liebermann TA, Schlessinger J et al. (1984): Human epidermal growth factor receptor cDNA sequences and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells. Nature 309:418-425. Ullrich A & Schlessinger J (1990): Signal transduction by receptors with tyrosine kinase activity. Cell 61: 203-212. Van der Geer P, Hunter T & Linberg RA (1994): Receptor protein-tyrosine kinases and their signal transduction pathways. Annual review in Cell Biology 10: 251-337. Voldborg BR, Damstrup L, Spang-Thopmsen M & Poulsen HS (1997): Epidermal growth factor Receptor (EGFR) and EGFR mutations, function and possible role in clinical trials. Annuals of Oncology 8:1197-1206. Walker RA & Dearing SJ (1999): Expression of epidermal growth factor receptor mRNA and protein in primary breast carcinomas. Breast Cancer Research Treatment 53:167-176. Zamore,P.D., Tuschl,T., Sharp,P.A„ and Bartel,D.P., 2000. RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell 101,25-33. Zor T & Selinger Z (1996): Linearization of the Bradford protein assay increases its sensitivity: theoretical and experimental studies. Anal. Biochem. 236: 302-308. SEQUENCE PROTOCOL Ribopharma AG Method to inhibit expression of a target gene 142 Patentln Ver. 2.1 1 2955 DNA Homo sapiens Eph Al NM00532 ephrin Al NM00532 1 atggagcggc gctggcccct ggggctaggg ctggtgctgc tgctctgcgc cccgctgccc 60 ccgggggcgc gcgccaagga agttactctg atggacacaa gcaaggcaca gggagagctg 120 ggctggctgc tggatccccc aaaagatggg tggagtgaac agcaacagat actgaatggg 180 acacccctct acatgtacca ggactgccca atgcaaggac gcagagacac tgaccactgg 240 cttcgctcca attggatcta ccgcggggag gaggcttccc gcgtccacgt ggagctgcag 300 ttcaccgtgc gggactgcaa gagtttccct gggggagccg ggcctctggg ctgcaaggag 360 accttcaacc ttctgtacat ggagagtgac caggatgtgg gcattcagct ccgacggccc 420 ttgttccaga aggtaaccac ggtggctgca gaccagagct tcaccattcg agaccttgcg 480 tctggctccg tgaagctgaa tgtggagcgc tgctctctgg gccgcctgac ccgccgtggc 540 ctctacctcg ctttccacaa cccgggtgcc tgtgtggccc tggtgtctgt ccgggtcttc 600 taccagcgct gtcctgagac cctgaatggc ttggcccaat tcccagacac tctgcctggc 660 cccgctgggt tggtggaagt ggcgggcacc tgcttgcccc acgcgcgggc cagccccagg 720 ccctcaggtg caccccgcat gcactgcagc cctgatggcg agtggctggt gcctgtagga 780 cggtgccact gtgagcctgg ctatgaggaa ggtggcagtg gcgaagcatg tgttgcctgc 840 cctagcggct cctaccggat ggacatggac acaccccatt gtctcacgtg cccccagcag 900 agcactgctg agtctgaggg ggccaccatc tgtacctgtg agagcggcca ttacagagct 960 cccggggagg gcccccaggt ggcatgcaca ggtcccccct cggccccccg aaacctgagc 1020 ttctctgcct cagggactca gctctccctg cgttgggaac ccccagcaga tacgggggga 1080 cgccaggatg tcagatacag tgtgaggtgt tcccagtgtc agggcacagc acaggacggg 1140 gggccctgcc agccctgtgg ggtgggcgtg cacttctcgc cgggggcccg ggcgctcacc 1200 acacctgcag tgcatgtcaa tggccttgaa ccttatgcca actacacctt taatgtggaa 1260 gcccaaaatg gagtgtcagg gctgggcagc tctggccatg ccagcacctc agtcagcatc 1320 agcatggggc atgcagagtc actgtcaggc ctgtctctga gactggtgaa gaaagaaccg 1380 aggcaactag agctgacctg ggcggggtcc cggccccgaa gccctggggc gaacctgacc 1440 tatgagctgc acgtgctgaa ccaggatgaa gaacggtacc agatggttct agaacccagg 1500 gtcttgctga cagagctgca gcctgacacc acatacatcg tcagagtccg aatgctgacc 1560 ccactgggtc ctggcccttt ctcccctgat catgagtttc ggaccagccc accagtgtcc 1620 aggggcctga ctggaggaga gattgtagcc gtcatctttg ggctgctgct tggtgcagcc 1680 ttgctgcttg ggattctcgt tttccggtcc aggagagccc agcggcagag gcagcagagg 1740 cacgtgaccg cgccaccgat gtggatcgag aggacaagct gtgctgaagc cttatgtggt 1800 acctccaggc atacgaggac cctgcacagg gagccttgga ctttacccgg aggctggtct 1860 aattttcctt cccgggagct tgatccagcg tggctgatgg tggacactgt cataggagaa 1920 ggagagtttg gggaagtgta tcgagggacc ctcaggctcc ccagccagga ctgcaagact 1980 gtggccatta agaccttaaa agacacatcc ccaggtggcc agtggtggaa cttccttcga 2040 gaggcaacta tcatgggcca gtttagccac ccgcatattc tgcatctgga aggcgtcgtc 2100 acaaagcgaa agccgatcat gatcatcaca gaatttatgg agaatgcagc cctggatgcc 2160 ttcctgaggg agcgggagga ccagctggtc cctgggcagc tagtggccat gctgcagggc 2220 atagcatctg gcatgaacta cctcagtaat cacaattatg tccaccggga cctggctgcc 2280 agaaacatct tggtgaatca aaacctgtgc tgcaaggtgt ctgactttgg cctgactcgc 2340 ctcctggatg actttgatgg cacatacgaa acccagggag gaaagatccc tatccgttgg 2400 acagcccctg aagccattgc ccatcggatc ttcaccacag ccagcgatgt gtggagcttt 2460 gggattgtga tgtgggaggt gctgagcttt ggggacaagc cttatgggga gatgagcaat 2520 caggaggtta tgaagagcat tgaggatggg taccggttgc cccctcctgt ggactgccct 2580 gcccctctgt atgagctcat gaagaactgc tgggcatatg accgtgcccg ccggccacac 2640 ttccagaagc ttcaggcaca tctggagcaa ctgcttgcca acccccactc cctgcggacc 2700 attgccaact ttgaccccag ggtgactctt cgcctgccca gcctgagtgg ctcagatggg 2760 atcccgtatc gaaccgtctc tgagtggctc gagtccatac gcatgaaacg ctacatcctg 2820 cacttccact cggctgggct ggacaccatg gagtgtgtgc tggagctgac cgctgaggac 2880 ctgacgcaga tgggaatcac actgcccggg caccagaagc gcattctttg cagtattcag 2940 ggattcaagg actga 2955 2 3042 DNA Homo sapiens ephrin A2 XM002088 2 gaagttgcgc gcaggccggc gggcgggagc ggacaccgag gccggcgtgc aggcgtgcgg 60 gtgtgcggga gccgggctcg gggggatcgg accgagagcg agaagcgcgg catggagctc 120 caggcagccc gcgcctgctt cgccctgctg tggggctgtg cgctggccgc ggccgcggcg 180 gcgcagggca aggaagtggt actgctggac tttgctgcag ctggagggga gctcggctgg 240 ctcacacacc cgtatggcaa agggtgggac ctgatgcaga acatcatgaa tgacatgccg 300 atctacatgt actccgtgtg caacgtgatg tctggcgacc aggacaactg gctccgcacc 360 aactgggtgt accgaggaga ggctgagcgt atcttcattg agctcaagtt tactgtacgt 420 gactgcaaca gcttccctgg tggcgccagc tcctgcaagg agactttcaa cctctactat 480 gccgagtcgg acctggacta cggcaccaac ttccagaagc gcctgttcac caagattgac 540 accattgcgc ccgatgagat caccgtcagc agcgacttcg aggcacgcca cgtgaagctg 600 aacgtggagg agcgctccgt ggggccgctc acccgcaaag gcttctacct ggccttccag 660 gatatcggtg cctgtgtggc gctgctctcc gtccgtgtct actacaagaa gtgccccgag 720 ctgctgcagg gcctggccca cttccctgag accatcgccg gctctgatgc accttccctg 780 gccactgtgg ccggcacctg tgtggaccat gccgtggtgc caccgggggg tgaagagccc 840 cgtatgcact gtgcagtgga tggcgagtgg ctggtgccca ttgggcagtg cctgtgccag 900 gcaggctacg agaaggtgga ggatgcctgc caggcctgct cgcctggatt ttttaagttt 960 gaggcatctg agagcccctg cttggagtgc cctgagcaca cgctgccatc ccctgagggt 1020 gccacctcct gcgagtgtga ggaaggcttc ttccgggcac ctcaggaccc agcgtcgatg 1080 ccttgcacac gacccccctc cgccccacac tacctcacag ccgtgggcat gggtgccaag 1140 gtggagctgc gctggacgcc ccctcaggac agcgggggcc gcgaggacat tgtctacagc 1200 gtcacctgcg aacagtgctg gcccgagtct ggggaatgcg ggccgtgtga ggccagtgtg 1260 cgctactcgg agcctcctca cggactgacc cgcaccagtg tgacagtgag cgacctggag 1320 ccccacatga actacacctt caccgtggag gcccgcaatg gcgtctcagg cctggtaacc 1380 agccgcagct tccgtactgc cagtgtcagc atcaaccaga cagagccccc caaggtgagg 1440 ctgSagggcc gcagcaccac ctcgcttagc gtctcctgga gcatcccccc gccgcagcag 1500 agccgagtgt ggaagtacga ggtcacttac cgcaagaagg gagactccaa cagctacaat 1560 gtgcgccgca ccgagggttt ctccgtgacc ctggacgacc tggccccaga caccacctac 1620 ctggtccagg tgcaggcact gacgcaggag ggccaggggg ccggcagcaa ggtgcacgaa 1680 ttccagacgc tgtccccgga gggatctggc aacttggcgg tgattggcgg cgtggctgtc 1740 ggtgtggtcc tgcttctggt gctggcagga gttggcttct ttatccaccg caggaggaag 1800 aaccagcgtg cccgccagtc cccggaggac gtttacttct ccaagtcaga acaactgaag 1860 cccctgaaga catacgtgga cccccacaca tatgaggacc ccaaccaggc tgtgttgaag 1920 ttcactaccg agatccatcc atcctgtgtc actcggcaga aggtgatcgg agcaggagag 1980 tttggggagg tgtacaaggg catgctgaag acatcctcgg ggaagaagga ggtgccggtg 2040 gccatcaaga cgctgaaagc cggctacaca gagaagcagc gagtggactt cctcggcgag 2100 gccggcatca tgggccagtt cagccaccac aacatcatcc gcctagaggg cgtcatctcc 2160 aaatacaagc ccatgatgat catcactgag tacatggaga atggggccct ggacaagttc 2220 cttcgggaga aggatggcga gttcagcgtg ctgcagctgg tgggcatgct gcggggcatc 2280 gcagctggca tgaagtacct ggccaacatg aactatgtgc accgtgacct ggctgcccgc 2340 aacatcctcg tcaacagcaa cctggtctgc aaggtgtctg actttggcct gtcccgcgtg 2400 ctggaggacg accccgaggc cacctacacc accagtggcg gcaagatccc catccgctgg 2460 accgccccgg aggccatttc ctaccggaag ttcacctctg ccagcgacgt gtggagcttt 2520 ggcattgtca tgtgggaggt gatgacctat ggcgagcggc cctactggga gttgtccaac 2580 cacgaggtga tgaaagccat caatgatggc ttccggctcc ccacacccat ggactgcccc 2640 tccgccatct accagctcat gatgcagtgc tggcagcagg agcgtgcccg ccgccccaag 2700 ttcgctgaca tcgtcagcat cctggacaag ctcattcgtg cccctgactc cctcaagacc 2760 ctggctgact ttgacccccg cgtgtctatc cggctcccca gcacgagcgg ctcggagggg 2820 gtgcccttcc gcacggtgtc cgagtggctg gagtccatca agatgcagca gtatacggag 2880 cacttcatgg cggccggcta cactgccatc gagaaggtgg tgcagatgac caacgacgac 2940 atcaagagga ttggggtgcg gctgcccggc caccagaagc gcatcgccta cagcctgctg 3000 ggactcaagg accaggtgaa cactgtgggg atccccatct ga 3042 3 2953 DNA Homo sapiens ephrin A3 NM005233 3 atggattgtc agctctccat cctcctcctt ctcagctgct ctgttctcga cagcttcggg 60 gaactgattc cgcagccttc caatgaagtc aatctactgg attcaaaaac aattcaaggg 120 gagctgggct ggatctctta tccatcacat gggtgggaag agatcagtgg tgtggatgaa 180 cattacacac ccatcaggac ttaccaggtg tgcaatgtca tggaccacag tcaaaacaat 240 tggctgagaa caaactgggt ccccaggaac tcagctcaga agatttatgt ggagctcaag 300 ttcactctac gagactgcaa tagcattcca ttggttttag gaacttgcaa ggagacattc 360 aacctgtact acatggagtc tgatgatgat catggggtga aatttcgaga gcatcagttt 420 acaaagattg acaccattgc agctgatgaa agtttcactc aaatggatct tggggaccgt 480 attctgaagc tcaacactga gattagagaa gtaggtcctg tcaacaagaa gggattttat 540 ttggcatttc aagatgttgg tgcttgtgtt gccttggtgt ctgtgagagt atacttcaaa 600 aagtgcccat ttacagtgaa gaatctggct cagtccctgg tggaggttag agggtcttgt aggatgtact gcagtacaga aggcgaatgg gctggctatg aagaaagagg ttttatgtgc ttggatggta atatgaagtg tgctaagtgc tcaatgaact gcaggtgtga gaataattac gcttgtaccc gacctccatc ttcaccaaga gttatcctgg actggagttg gcccctggac atcatatgta aaaaatgtgg gtggaatata cgcttcctcc ctcgacagtt tggactcacc gcacatacta actacacctt tgagattgat ccaccaagac agtttgctgc ggtcagcatc ctgacgatta agaaagatcg gacctccaga gaacatccta atgggatcat attggactac gaaacaagtt ataccattct gagggcaaga cctgacacta tatacgtatt ccaaatccga agccgcaagt ttgagtttga aactagtcca caagtggtca tgatcgccat ttcagcggca tatgttttga ttgggaggtt ctgtggctat cttcattttg gcaatgggca tttaaaactt acatatgaag accctaccca agctgttcat atatccattg ataaagttgt tggagcaggt aaacttcctt caaaaaaaga gatttcagtg gaaaagcaga ggagagactt cctgggagaa aatatcattc gactggaagg agttgttacc tacatggaga atggttcctt ggatagtttc attcagctag tggggatgct tcgagggata ggctatgttc accgagacct cgctgctcgg aaggtttctg atttcggact ttcgcgtgtc acaagaggag ggaagatccc aatcaggtgg ttcacgtcag ccagcgatgt atggagttat atgtttccag acacggtacc catggactcc 660 gtcaacaatt ctaaggagga agatcctcca 720 cttgtaccca ttggcaagtg ttcctgcaat 780 caagcttgtc gaccaggttt ctacaaggca 840 ccgcctcaca gttctactca ggaagatggt 900 ttccgggcag acaaagaccc tccatccatg 960 aatgttatct ctaatataaa cgagacctca 1020 acaggaggcc ggaaagatgt taccttcaac 1080 aaacagtgtg agccatgcag cccaaatgtc 1140 aacaccacgg tgacagtgac agaccttctg 1200 gccgttaatg gggtgtcaga gctgagctcc 1260 acaactaatc aggctgctcc atcacctgtc 1320 aatagcatct ctttgtcctg gcaagaacct 1380 gaggtcaaat actatgaaaa gcaggaacaa 1440 ggcacaaatg ttaccatcag tagcctcaag 1500 gcccgaacag ccgctggata tgggacgaac 1560 gactctttct ccatctctgg tgaaagtagc 1620 gtagcaatta ttctcctcac tgttgtcatc 1680 aagtcaaaac atggggcaga tgaaaaaaga 1740 ccaggtctca ggacttatgt tgacccacat 1800 gagtttgcca aggaattgga tgccaccaac 1860 gaatttggag aggtgtgcag tggtcgctta 1920 gccattaaaa ccctgaaagt tggctacaca 1980 gcaagcatta tgggacagtt tgaccacccc 2040 aaaagtaagc cagttatgat tgtcacagaa 2100 ctacgtaaac acgatgccca gtttactgtc 2160 gcatctggca tgaagtacct gtcagacatg 2220 aacatcttga tcaacagtaa cttggtgtgt 2280 ctggaggatg acccagaagc tgcttataca 2340 acatcaccag aagctatagc ctaccgcaag 2400 gggattgttc tetgggaggt gatgtcttat 2460 ggagagagac catactggga gatgtccaat tatcgactgc caccccccat ggactgccca tggcagaaag acaggaacaa cagacccaag cttatccgga atcccggcag cctgaagatc cttcttctgg accaaagcaa tgtggatatc aatggtgtcc ggacagcaca ctgcaaggaa gacacaatag ccaagatttc cacagatgac ccacagaaga agatcatcag tagcattaaa gttcccgtgt aaa 4 2784 DNA Homo sapiens ephrin A4 XM002578 caggatgtaa ttaaagctgt agatgagggc 2520 gctgccttgt atcagctgat gctggactgc 2580 tttgagcaga ttgttagtat tctggacaag 2640 atcaccagtg cagccgcaag zzgccatcaaac 2700 tctaccttcc gcacaacagg tgactggctt 2760 atcttcacgg gcgtggagta cagttcttgt 2820 atgaaaaagg ttggtgtcac cgtggttggg 2880 gctctagaaa cgcaatcaaa gaatggccca 2940 2953 4 atggatgaaa aaaatacacc aatccgaacc cagaataact ggctacgaac tgattggatc gagattaaat tcaccttgag ggactgcaat gagacgttta acctgtacta ctatgaatcca aaccagtttg tcaaaattga caccattgct ggtgacagaa tcatgaagct gaacaccgag gggttttacc tggcttttca ggatgtgggg ttctataaaa agtgtccact cacagtccgc ggggctgata cgtcttccct ggtggaagtt aaagatgtgc caaaaatgta ctgtggggca tgcctatgca acgctgggca tgaggagcgg taccaagtgt gcaatgtgat ggaacccagc 60 acccgagaag gggctcagag ggtgtatatt 120 agtcttccgg gcgtcatggg gacttgcaag 180 gacaacgaca aagagcgttt catcagagag 240 gctgatgaga gcttcaccca agtggacatt 300 atccgggatg tagggccatt aagcaaaaag 360 gcctgcatcg ccctggtatc agtccgtgtg 420 aatctggccc agtttcctga caccatcaca 480 cgaggctcct gtgtcaacaa ctcagaagag 540 gatggtgaat ggctggtacc cattggcaac 600 agcggagaat gccaagcttg caaaattgga 660 tattacaagg ctctctccac ggatgccacc tgtgccaagt gcccacccca cagctactct 720 gtctgggaag gagccacctc gtgcacctgt gaccgaggct ttttcagagc tgacaacgat 780 gctgcctcta tgccctgcac ccgtccacca tctgctcccc tgaacttgat ttcaaatgtc 840 aacgagacat ctgtgaactt ggaatggagt agccctcaga atacaggtgg ccgccaggac 900 atttcctata atgtggtatg caagaaatgt ggagctggtg accccagcaa gtgccgaccc 960 tgtggaagtg gggtccacta caccccacag cagaatggct tgaagaccac caaagtctcc 1020 atcactgacc tcctagctca taccaattac acctttgaaa tctgggctgt gaatggagtg 1080 tccaaatata accctaaccc agaccaatca gtttctgtca ctgtgaccac caaccaagca 1140 gcaccatcat ccattgcttt ggtccaggct aaagaagtca caagatacag tgtggcactg 1200 gcttggctgg aaccagatcg gcccaatggg gtaatcctgg aatatgaagt caagtattat 1260 gagaaggatc agaatgagcg aagctatcgt atagttcgga cagctgccag gaacacagat 1320 atcaaaggcc tgaaccctct cacttcctat gttttccacg tgcgagccag gacagcagct 1380 ggctatggag acttcagtga gcccttggag gttacaacca acacagtgcc ttcccggatc 1440 attggagatg gggctaactc cacagtcctt ctggtctctg tctcgggcag tgtggtgctg 1500 gtggtaattc tcattgcagc ttttgtcatc agccggagac ggagtaaata cagtaaagcc 1560 aaacaagaag cggatgaaga gaaacatttg aatcaaggtg taagaacata tgtggacccc 1620 tttacgtacg aagatcccaa ccaagcagtg cgagagtttg ccaaagaaat tgacgcatcc 1680 tgcattaaga ttgaaaaagt tataggagtt ggtgaatttg gtgaggtatg cagtgggcgt 1740 ctcaaagtgc ctggcaagag agagatctgt gtggctatca agactctgaa agctggttat 1800 acagacaaac agaggagaga cttcctgagt gaggccagca tcatgggaca gtttgaccat 1860 ccgaacatca ttcacttgga aggcgtggtc actaaatgta aaccagtaat gatcataaca 1920 gagtacatgg agaatggctc cttggatgca ttcctcagga aaaatgatgg cagatttaca 1980 gtcattcagc tggtgggcat gcttcgtggc attgggtctg ggatgaagta tttatctgat 2040 atgagctatg tgcatcgtga tctggccgca cggaacatcc tggtgaacag caacttggtc 2100 tgcaaagtgt ctgattttgg catgtcccga gtgcttgagg atgatccgga agcagcttac 2160 accaccaggg gtggcaagat tcctatccgg tggactgcgc cagaagcaat tgcctatcgt 2220 aaattcacat cagcaagtga tgtatggagc tatggaatcg ttatgtggga agtgatgtcg 2280 tacggggaga ggccctattg ggatatgtcc aatcaagatg tgattaaagc cattgaggaa 2340 ggctatcggt taccccctcc aatggactgc cccattgcgc tccaccagct gatgctagac 2400 tgctggcaga aggagaggag cgacaggcct aaatttgggc agattgtcaa catgttggac 2460 aaactcatcc gcaaccccaa cagcttgaag aggacaggga cggagagctc cagacctaac 2520 actgccttgt tggatccaag ctcccctgaa ctccaggcca ttaaaatgga ccggtataag ctagaggctg tggtgcacgt gaaccaggag acgcaccaga ataagatttt gagcagtgtc cacggcagaa tggttcccgt ctga 5 2997 DNA Homo sapiens ephrin A7 XM004485 5 atggtttttc aaactcggta cccttcatgg tttgcacaca caggggaggc gcaggctgcg caacaaacag agttggagtg gatttcctct ttggatgaga actatacccc gatacgaaca caaaacaact ggctgcggac taactggatt gaattgaaat tcaccctgag ggattgtaac gaaacattta atttgtacta ttatgaaaca aacctctatg taaaaataga caccattgct ggtgaaagaa agatgaagct taacactgag ggattctatc ttgcctttca ggatgtaggg tactacaaga agtgctggtc cattattgag ggttcagaat tttcctcttt agtcgaggtt gaagcggaaa acgcccccag gatgcactgc ggaaaatgta tctgcaaagc aggctaccag cgtgggttct acaagtcttc ctctcaagat ttttctgata aagaaggctc ctccagatgt ttctctgctg tggtatcagt gggcgattgg 2580 gataacttca cagctgctgg ttataccaca 2640 gacctggcaa gaattggtat cacagccatc 2700 caggcaatgc gaacccaaat gcagcagatg 2760 2784 attattttat gctacatctg gctgctccgc 60 aaggaagtac tactgctgga ttctaaagca 120 ccacccaatg ggtgggaaga aattagtggt 180 taccaggtgt gccaagtcat ggagcccaac 240 tccaaaggca atgcacaaag gatttttgta 300 agtcttcctg gagtactggg aacttgcaag 360 gactatgaca ctggcaggaa tataagagaa 420 gcagatgaaa gttttaccca aggtgacctt 480 gtgagagaga ttggaccttt gtccaaaaag 540 gcttgcatag ctttggtttc tgtcaaagtg 600 aacttagcta tctttccaga tacagtgact 660 cgagggacat gtgtcagcag tgcagaggaa 720 agtgcagaag gagaatggtt agtgcccatt 780 caaaaaggag acacttgtga accctgtggc 840 cttcagtgct ctcgttgtcc aactcacagt 900 gaatgtgaag atgggtatta cagggctcca 960 tctgacccac catacgttgc atgcacaagg aacatcaacc aaaccacagt aagtttggaa aacgatgtga cctacagaat attgtgtaag ccctgtggga gtaacattgg atacatgccc actgtcatgg acctgctagc ccacgctaat gtttctgact taagccgatc ccagaggctc gcagctccct cgcaagtgag tggagtaatg ctttcctggc aggaaccaga gcatcccaat tacgagaaag atcaaaggga acggacctac tecattaata atetgaaacc aggaacagtg gctggttatg gaaattacag tcccagactt aaaatgtttg aagctacagc tgtctccagt gttgctgtag ctgggaccat cattttggtg aggcactgtg gttatagcaa agctgaccaa aaatttccag gcaccaaaac ctacattgac gtccatcaat tcgccaagga gctagatgcc gcaggagaat tcggtgaagt ctgcagtggc gcagtagcca taaaaaccct gaaagttggt tgtgaagcaa gcatcatggg gcagtttgac gttacaagag ggaaaccagt catgatagtc gcatttctca ggaaacatga tgggcaattt ggaattgctg ctggaatgag atatttggct gctcgcaata ttcttgtcaa cagcaatctc cgagttatag aggatgatcc agaagctgtc aggtggacag cacccgaagc catccagtaC agctatggaa tagtcatgtg ggaagttatg tcaaatcaag atgttataaa agcaatagaa tgcccagctg gccttcacca gctaatgttg ccaaaatttg aacagatagt tggaattcta aaaactcccc tgggaacttg tagtaggcca gatttcacta ccttttgttc agttggagaa cctccatctg caccacagaa cctcattttc 1020 tggagtcctc ctgcagacaa tgggggaaga 1080 cggtgcagtt gggagcaggg cgaatgtgtt 1140 cagcagactg gattagagga taactatgtc 1200 tatacttttg aagttgaagc tgtaaatgga 1260 tttgctgctg tcagtatcac cactggtcaa 1320 aaggagagag tactgcagcg gagtgtcgag 1380 ggagtcatca cagaatatga aatcaagtat 1440 tcaacagtaa aaaccaagtc tacttcagcc 1500 tatgttttcc agattcgggc ttttactgct 1560 gatgttgcta cactagagga agctacaggt 1620 gaacagaatc ctgttattat cattgctgtg 1680 ttcatggtct ttggcttcat cattgggaga 1740 gaaggcgatg aagagcttta ctttcatttt 1800 cctgaaacct atgaggaccc aaatagagct 1860 tcctgtatta aaattgagcg tgtgattggt 1920 cgtttgaaac ttccagggaa aagagatgtt 1980 tacacagaaa aacaaaggag agactttttg 2040 cacccaaatg ttgtccattt ggaaggggtt 2100 atagagttca tggaaaatgg agccctagat 2160 acagtcattc agttagtagg aatgctgaga 2220 gatatgggat atgttcacag ggaccttgca 2280 gtttgtaaag tgtcagattt tggcctgtcc 2340 tatacaacta ctggtggaaa aattccagta 2400 cggaaattca catcagccag tgatgtatgg 2460 tcttatggag aaagacctta ttgggacatg 2520 gaaggttatc gtttaccagc acccatggac 2580 gattgttggc aaaaggagcg tgctgaaagg 2640 gacaaaatga ttcgaaaccc aaatagtctg 2700 ataagccctc ttctggatca aaacactcct 2760 tggctacaag ctattaagat ggaaagatat 2820 aaagataatt tcacggcagc tggctacaat tcccttgaat cagtagccag gatgactatt 2880 gaggatgtga tgagtttagg gatcacactg gttggtcatc aaaagaaaat catgagcagc 2940 attcagacta tgagagcaca aatgctacat ttacatggaa ctggcattca agtgtga 2997 6 3217 DNA Homo sapiens ephrin A8 XM001921 6 ncbsncvwrb mdnctdrtng nmstrctrst tanmymmsar chbmdrtnnc tdstrctrgn 60 mstmmtanmy rmtsndhstr ycbardasna stagnbankg rahcsmdatv washtmantt 120 hdbrandnkb arggnbankh msanshahar tntanmycsm bmrnarnvdn tnhmsansha 180 hamrnaaccs snmvrsnmga tggcccccgc ccggggccgc ctgccccctg cgctctgggt 240 cgtcacggcc gcggcggcgg cggccacctg cgtgtccgcg gcgcgcggcg aagtgaattt 300 gctggacacg tcgaccatcc acggggactg gggctggctc acgtatccgg ctcatgggtg 360 ggactccatc aacgaggtgg acgagtcctt ccagcccatc cacacgtacc aggtttgcaa 420 cgtcatgagc cccaaccaga acaactggct gcgcacgagc tgggtccccc gagacggcgc 480 ccggcgcgtc tatgctgaga tcaagtttac cctgcgcgac tgcaacagca tgcctggtgt 540 gctgggcacc tgcaaggaga ccttcaacct ctactacctg gagtcggacc gcgacctggg 600 ggccagcaca caagaaagcc agttcctcaa aatcgacacc attgcggccg acgagagctt 660 cacaggtgcc gaccttggtg tgcggcgtct caagctcaac acggaggtgc gcagtgtggg 720 tcccctcagc aagcgcggct tctacctggc cttccaggac ataggtgcct gcctggccat 780 cctctctctc cgcatctact ataagaagtg ccctgccatg gtgcgcaatc tggctgcctt 840 ctcggaggca gtgacggggg ccgactcgtc ctcactggtg gaggtgaggg gccagtgcgt 900 gcggcactca gaggagcggg acacacccaa gatgtactgc agcgcggagg gcgagtggct 960 cgtgcccatc ggcaaatgcg tgtgcagtgc cggctacgag gagcggcggg atgcctgtgt 1020 ggcctgtgag ctgggcttct acaagtcagc ccctggggac cagctgtgtg cccgctgccc 1080 tccccacagc cactccgcag ctccagccgc ccaagcctgc cactgtgacc tcagctacta 1140 ccgtgcagcc ctggacccgc cgtcctcagc ctgcacccgg ccaccctcgg caccagtgaa 1200 cctgatctcc agtgtgaatg ggacatcagt gactctggag tgggcccctc ccctggaccc 1260 agtgacatca cctacaatgc cgtgtgccgc cgctgcccct gggcactgag 1320 ccgctgcgag gcatgtggga gcggcacccg ctttgtgccc cagcagacaa gcctggtgca 1380 ggccagcctg ctggtggcca acctgctggc ccacatgaac tactccttct ggatcgaggc 1440 cgtcaatggc gtgtccgacc tgagccccga gccccgccgg gccgctgtgg tcaacatcac 1500 cacgaaccag gcagccccgt cccaggtggt ggtgatccgt caagagcggg cggggcagac 1560 cagcgtctcg ctgctgtggc aggagcccga gcagccgaac ggcatcatcc tggagtatga 1620 gatcaagtac tacgagaagg acaaggagat gcagagctac tccaccctca aggccgtcac 1680 caccagagcc accgtctccg gcctcaagcc gggcacccgc tacgtgttcc aggtccgagc 1740 ccgcacctca gcaggctgtg gccgcttcag ccaggccatg gaggtggaga ccgggaaacc 1800 ccggccccgc tatgacacca ggaccattgt ctggatctgc ctgacgctca tcacgggcct 1860 ggtggtgctt ctgctcctgc tcatctgcaa gaagaggcac tgtggctaca gcaaggcctt 1920 ccaggactcg gacgaggaga agatgcacta tcagaatgga caggcacccc cacctgtctt 1980 cctgcctctg catcaccccc cgggaaagct cccagagccc cagttctatg cggaacccca 2040 cacctacgag gagccaggcc gggcgggccg cagtttcact cgggagatcg aggcctctag 2100 gatccacatc gagaaaatca tcggctctgg agactccggg gaagtctgct acgggaggct 2160 gcgggtgcca gggcagcggg atgtgcccgt ggccatcaag gccctcaaag ccggctacac 2220 ggagagacag aggcgggact tcctgagcga ggcgtccatc atggggcaat tcgaccatcc 2280 caacatcatc cgcctcgagg gtgtcgtcac ccgtggccgc ctggcaatga ttgtgactga 2340 gtacatggag aacggctctc tggacacctt cctgaggacc cacgacgggc agttcaccat 2400 catgcagctg gtgggcatgc tgagaggagt gggtgccggc atgcgctacc tctcagacct 2460 gggctatgtc caccgagacc tggccgcccg caacgtcctg gttgacagca acctggtctg 2520 caaggtgtct gacttcgggc tctcacgggt gctggaggac gacccggatg ctgcctacac 2580 caccacgggc gggaagatcc ccatccgctg gacggcccca gaggccatcg ccttccgcac 2640 cttctcctcg gccagcgacg tgtggagctt cggcgtggtc atgtgggagg tgctggccta 2700 tggggagcgg ccctactgga acatgaccaa ccgggatgtc atcagctctg tggaggaggg 2760 gtaccgcctg cccgcaccca tgggctgccc ccacgccctg caccagctca tgctcgactg 2820 ttggcacaag gaccgggcgc agcggcctcg cttctcccag attgtcagtg tcctcgatgc 2880 gctcatccgc agccctgaga gtctcagggc caccgccaca gtcagcaggt gcccaccccc 2940 tgccttcgtc cggagctgct ttgacctccg agggggcagc ggtggcggtg ggggcctcac 3000 cgtgggggac tggctggact ccatccgcat gggccggtac cgagaccact tcgctgcggg 3060 cggatactcc tctctgggca tggtgctacg catgaacgcc caggacgtgc gcgccctggg 3120 catcaccctc atgggccacc agaagaagat cctgggcagc attcagacca tgcgggccca 3180 gctgaccagc acccaggggc cccgccggca cctctga 3217 7 1497 DNA Homo sapiens U83508 angiopoietin 2 U83508 7 atgacagttt tcctttcctt tgctttcctc gctgccattc tgactcacat agggtgcagc 60 aatcagcgcc gaagtccaga aaacagtggg agaagatata accggattca acatgggcaa 120 tgtgcctaca ctttcattct tccagaacac gatggcaact gtcgtgagag tacgacagac 180 cagtacaaca caaacgctct gcagagagat gctccacacg tggaaccgga tttctcttcc 240 cagaaacttc aacatctgga acatgtgatg gaaaattata ctcagtggct gcaaaaactt 300 gagaattaca ttgtggaaaa catgaagtcg gagatggccc agatacagca gaatgcagtt 360 cagaaccaca cggctaccat gctggagata ggaaccagcc tcctctctca gactgcagag 420 cagaccagaa agctgacaga tgttgagacc caggtactaa atcaaacttc tcgacttgag 480 atacagctgc tggagaattc attatccacc tacaagctag agaagcaact tcttcaacag 540 acaaatgaaa tcttgaagat ccatgaaaaa aacagtttat tagaacataa aatcttagaa 600 atggaaggaa aacacaagga agagttggac accttaaagg aagagaaaga gaaccttcaa 660 ggcttggtta ctcgtcaaac atatataatc caggagctgg aaaagcaatt aaacagagct 720 accaccaaca acagtgtcct tcagaagcag caactggagc tgatggacac agtccacaac 780 cttgtcaatc tttgcactaa agaaggtgtt ttactaaagg gaggaaaaag agaggaagag 840 aaaccattta gagactgtgc agatgtatat caagctggtt ttaataaaag tggaatctac 900 actatttata ttaataatat gccagaaccc aaaaaggtgt tttgcaatat ggatgtcaat 960 gggggaggtt ggactgtaat acaacatcgt gaagatggaa gtctagattt ccaaagaggc 1020 tggaaggaat ataaaatggg ttttggaaat ccctccggtg aatattggct ggggaatgag 1080 tttatttttg ccattaccag tcagaggcag tacatgctaa gaattgagtt aatggactgg 1140 gaagggaacc gagcctattc acagtatgac agattccaca taggaaatga aaagcaaaac 1200 tataggttgt atttaaaagg tcacactggg acagcaggaa aacagagcag cctgatctta 1260 cacggtgctg atttcagcac taaagatgct gataatgaca actgtatgtg caaatgtgcc 1320 ctcatgttaa caggaggatg gtggtttgat gcttgtggcc cctccaatct aaatggaatg 1380 ttctatactg cgggacaaaa ccatggaaaa ctgaatggga taaagtggca ctacttcaaa 1440 gggcccagtt actccttacg ttccacaact atgatgattc gacctttaga tttttga 1497 8 3417 DNA Homo sapiens XM001924 Tiel 8 atggtctggc gggtgccccc tttcttgctc cccatcctct tcttggcttc gcggcggtgg acctgacgct gctggccaac ctgcggctca cggaccccca ctgacttgcg tgtctgggga ggccggggcg gggaggggct cggacgcctg ctgctgctgg agaaggacga ccgtatcgtg cgcaccccgc ccgggccacc gcgcgcaacg gttcgcacca ggtcacgctt cgcggcttct ccaagccctc tcatgtgggc 60 gcgcttcttc 120 gggcccgccc 180 cctgcgcctg 240 ggacctcgtg 300 ggcgtcttct cctgcgtggg cggtgctggg gcgcggcgca cgcgcgtcat ctacgtgcac 360 aacagccctg gagcccacct gcttccagac aaggtcacac acactgtgaa caaaggtgac 420 accgctgtac tttctgcacg tgtgcacaag gagaagcaga cagacgtgat ctggaagagc 480 aacggatcct acttctacac cctggactgg catgaagccc aggatgggcg gttcctgctg 540 cagctcccaa atgtgcagcc accatcgagc ggcatctaca gtgccactta cctggaagcc 600 agccccctgg gcagcgcctt ctttcggctc atcgtgcggg gttgtggggc tgggcgctgg 660 gggccaggct gtaccaagga gtgcccaggt tgcctacatg gaggtgtctg ccacgaccat 720 gacggcgaat gtgtatgccc ccctggcttc actggcaccc gctgtgaaca ggcctgcaga 780 gagggccgtt ttgggcagag ctgccaggag cagtgcccag gcatatcagg ctgccggggc 840 ctcaccttct gcctcccaga cccctatggc tgctcttgtg gatctggctg gagaggaagc 900 cagtgccaag aagcttgtgc ccctggtcat tttggggctg attgccgact ccagtgccag 960 tgtcagaatg gtggcacttg tgaccggttc agtggttgtg tctgcccctc tgggtggcat 1020 ggagtgcact gtgagaagtc agaccggatc ccccagatcc tcaacatggc ctcagaactg 1080 gagttcaact tagagacgat gccccggatc aactgtgcag ctgcagggaa ccccttcccc 1140 gtgcggggca gcatagagct acgcaagcca gacggcactg tgctcctgtc caccaaggcc 1200 attgtggagc cagagaagac cacagctgag ttcgaggtgc cccgcttggt tcttgcggac 1260 agtgggttct gggagtgccg tgtgtccaca tctggcggcc aagacagccg gcgcttcaag 1320 gtcaatgtga aagtgccccc cgtgcccctg gctgcacctc ggctcctgac caagcagagc 1380 cgccagcttg tggtctcccc gctggtctcg ttctctgggg atggacccat ctccactgtc 1440 cgcctgcact accggcccca ggacagtacc atggactggt cgaccattgt ggtggacccc 1500 agtgagaacg tgacgttaat gaacctgagg ccaaagacag gatacagtgt tcgtgtgcag 1560 ctgagccggc caggggaagg aggagagggg gcctgggggc ctcccaccct catgaccaca 1620 gactgtcctg agcctttgtt gcagccgtgg ttggagggct ggcatgtgga aggcactgac 1680 cggctgcgag tgagctggtc cttgcccttg gtgcccgggc cactggtggg cgacggtttc 1740 ctgctgcgcc tgtgggacgg gacacggggg caggagcggc gggagaacgt ctcatccccc 1800 caggcccgca ctgccctcct gacgggactc acgcctggca cccactacca gctggatgtg 1860 cagctctacc actgcaccct cctgggcccg gcctcgcccc ctgcacacgt gcttctgccc 1920 cccagtgggc ctccagcccc ccgacacctc cacgcccagg ccctctcaga ctccgagatc 1980 cagctgacat ggaagcaccc ggaggctctg cctgggccaa tatccaagta cgttgtggag 2040 gtgcaggtgg ctgggggtgc aggagaccca ctgtggatag acgtggacag gcctgaggag 2100 acaagcacca tcatccgtgg cctcaacgcc agcacgcgct acctcttccg catgcgggcc 2160 agcattcagg ggctcgggga ctggagcaac ctgcaggctg agggcccagt ccaagagagc ctgatcctgg cggtggtggg ctccgtgtct ttaaccctgg tgtgcatccg cagaagctgc tcaggctcgg gcgaggagac catcctgcag cggccaaaac tgcagcccga gcccctgagc tttgaggacc tcatcgggga ggggaacttc gacgggctga agatgaacgc agccatcaaa catcgtgact ttgcgggaga actggaagtt atcaacctcc tgggggcctg taagaaccga ccctacggga acctgctaga ttttctgcgg tttgctcgag agcatgggac agcctctacc agtgatgcgg ccaatggcat gcagtacctg gctgcccgga atgtgctggt cggagagaac tetcggggag aggaggttta tgtgaagaag gccattgagt ccctgaacta cagtgtctat gtccttcttt gggagatagt gagccttgga gagctctatg aaaagctgcc ccagggctac gaagtgtacg agctgatgcg tcagtgctgg gcccagattg cgctacagct aggccgcatg tcgctgtttg agaacttcac ttacgcgggc 9 3375 DNA Homo sapiens TEK L06139 acagtagaag agtccaccct gggcaacggg 2220 cgggcagctg aagagggcct ggatcagcag 2280 gccacctgcc tcaccatcct ggctgccctt 2340 ctgcatcgga gacgcacctt cacctaccag 2400 ttcagctcag ggaccttgac acttacccgg 2460 tacccagtgc tagagtggga ggacatcacc 2520 ggccaggtca tccgggccat gatcaagaag 2580 atgctgaaag agtatgcctc tgaaaatgac 2640 ctgtgcaaat tggggcatca ccccaacatc 2700 ggttacttgt atatcgctat tgaatatgcc 2760 aaaagccggg tcctagagac tgacccagct 2820 cttagctccc ggcagctgct gcgtttcgcc 2880 agtgagaagc agttcatcca cagggacctg 2940 ctggcctcca agattgcaga cttcggcctt 3000 acgatggggc gtctccctgt gcgctggatg 3060 accaccaaga gtgatgtctg gtcctttgga 3120 ggtacaccct actgtggcat gacctgtgcc 3180 cgcatggagc agcctcgaaa ctgtgacgat 3240 cgggaccgtc cctatgagcg accccccttt 3300 ctggaagcca ggaaggccta tgtgaacatg 3360 attgatgcca cagctgagga ggcctga 3417 9 atggactctt tagccagctt agttctctgt ggagtcagct tgctcctttc tggaactgtg 60 gaaggtgcca tggacttgat cttgatcaat tccctacctc ttgtatctga tgctgaaaca 120 tctctcacct gcattgcctc tgggtggcgc ccccatgagc ccatcaccat aggaagggac 180 tttgaagcct taatgaacca gcaccaggat ccgctggaag ttactcaaga tgtgaccaga 240 gaatgggcta aaaaagttgt ttggaagaga gaaaaggcta gtaagatcaa tggtgcttat 300 ttctgtgaag ggcgagttcg aggagaggca atcaggatac gaaccatgaa gatgcgtcaa 360 caagcttcct tcctaccagc tactttaact atgactgtgg acaagggaga taacgtgaac 420 atatctttca aaaaggtatt gattaaagaa gaagatgcag tgatttacaa aaatggttcc 480 ttcatccatt cagtgccccg gcatgaagta cctgatattc tagaagtaca cctgcctcat 540 gctcagcccc aggatgctgg agtgtactcg gccaggtata taggaggaaa cctcttcacc 600 tcggccttca ccaggctgat agtccggaga tgtgaagccc agaagtgggg acctgaatgc 660 aaccatctct gtactgcttg tatgaacaat ggtgtctgcc atgaagatac tggagaatgc 720 atttgccctc ctgggtttat gggaaggacg tgtgagaagg cttgtgaact gcacacgttt 780 ggcagaactt gtaaagaaag gtgcagtgga caagagggat gcaagtctta tgtgttctgt 840 ctccctgacc cctatgggtg ttcctgtgcc acaggctgga agggtctgca gtgcaatgaa 900 gcatgccacc ctggttttta cgggccagat tgtaagctta ggtgcagctg caacaatggg 960 gagatgtgtg atcgcttcca aggatgtctc tgctctccag gatggcaggg gctccagtgt 1020 gagagagaag gcataccgag gatgacccca aagatagtgg atttgccaga tcatatagaa 1080 gtaaacagtg gtaaatttaa tcccatttgc aaagcttctg gctggccgct acctactaat 1140 gaagaaatga ccctggtgaa gccggatggg acagtgctcc atccaaaaga ctttaaccat 1200 acggatcatt tctcagtagc catattcacc atccaccgga tcctcccccc tgactcagga 1260 gtttgggtct gcagtgtgaa cacagtggct gggatggtgg aaaagccctt caacatttct 1320 gttaaagttc ttccaaagcc cctgaatgcc ccaaacgtga ttgacactgg acataacttt 1380 gctgtcatca acatcagctc tgagccttac tttggggatg gaccaatcaa atccaagaag 1440 cttctataca aacccgttaa tcactatgag gcttggcaac atattcaagt gacaaatgag 1500 attgttacac tcaactattt ggaacctcgg acagaatatg aactctgtgt gcaactggtc 1560 cgtcgtggag agggtgggga agggcatcct ggacctgtga gacgcttcac aacagcttct 1620 atcggactcc ctcctccaag aggtctaaat ctcctgccta aaagtcagac cactctaaat 1680 ttgacctggc aaccaatatt tccaagctcg gaagatgact tttatgttga agtggagaga 1740 aggtctgtgc aaaaaagtga tcagcagaat attaaagttc caggcaactt gacttcggtg 1800 ctacttaaca acttacatcc cagggagcag tacgtggtcc gagctagagt caacaccaag 1860 gcccaggggg aatggagtga agatctcact gcttggaccc ttagtgacat tcttcctcct 1920 caaccagaaa acatcaagat ttccaacatt acacactcct cggctgtgat ttcttggaca 1980 atattggatg gctattctat ttcttctatt actatccgtt acaaggttca aggcaagaat 2040 gaagaccagc acgttgatgt gaagataaag aatgccacca tcattcagta tcagctcaag 2100 ggcctagagc ctgaaacagc ataccaggtg gacatttttg cagagaacaa catagggtca 2160 agcaacccag ccttttctca tgaactggtg accctcccag aatctcaagc accagcggac 2220 ctcggagggg ggaagatgct gcttatagcc atccttggct ctgctggaat gacctgcctg 2280 actgtgctgt tggcctttct gatcatattg caattgaaga gggcaaatgt gcaaaggaga 2340 atggcccaag ccttccaaaa cgtgagggaa gaaccagctg tgcagttcaa ctcagggact 2400 ctggccctaa acaggaaggt caaaaacaac ccagatccta caatttatcc agtgcttgac 2460 tggaatgaca tcaaatttca agatgtgatt ggggagggca attttggcca agttcttaag 2520 gcgcgcatca agaaggatgg gttacggatg gatgctgcca tcaaaagaat gaaagaatat 2580 gcctccaaag atgatcacag ggactttgca ggagaactgg aagttctttg taaacttgga 2640 caccatccaa acatcatcaa tctcttagga gcatgtgaac atcgaggcta cttgtacctg 2700 gccattgagt acgcgcccca tggaaacctt ctggacttcc ttcgcaagag ccgtgtgctg 2760 gagacggacc cagcatttgc cattgccaat agcaccgcgt ccacactgtc ctcccagcag 2820 ctccttcact tcgctgccga cgtggcccgg ggcatggact acttgagcca aaaacagttt 2880 atccacaggg atctggctgc cagaaacatt ttagttggtg aaaactatgt ggcaaaaata 2940 gcagattttg gattgtcccg aggtcaagag gtgtacgtga aaaagacaat gggaaggctc 3000 ccagtgcgct ggatggccat cgagtcactg aattacagtg tgtacacaac caacagtgat 3060 gtatggtcct atggtgtgtt actatgggag attgttagct taggaggcac accctactgc 3120 gggatgactt gtgcagaact ctacgagaag ctgccccagg gctacagact ggagaagccc 3180 ctgaactgtg atgatgaggt gtatgatcta atgagacaat gctggcggga gaagccttat 3240 gagaggccat catttgccca gatattggtg tccttaaaca gaatgttaga ggagcgaaag 3300 acctacgtga ataccacgct ttatgagaag tttacttatg caggaattga ctgttctgct 3360 gaagaagcgg cctag 3375 10 2409 DNA Homo sapiens beta5 integrin X53002 10 ncbsncvwra tgccgcgggc cccggcgccg ctcctgcccc ggctcgcagg tctcaacata gaatgtctgc taatccaccc aaaatgtgcc cggtccatca cctctcggtg tgatctgagg gagatagaga gcccagccag cagcttccat ggttcgggct ctgcaggctg ggacgtcatt ctccggcccg gtgacaagac caccttccag gtggacctgt actacctgat ggacctctcc cggagcctgg gcaccaaact cgcggaggag ggatttgggt cttttgttga taaggacatc cagaccaatc cgtgcattgg ttacaagttg cgccatctgc tgcctctcac agacagagtg agggtgtccc ggaaccgaga tgcccctgag gtctgcaagg agaagattgg ctggcgaaag gatgatgtgc cccacatcgc attggatgga ggccagtgcc acctgaacga ggccaacgag tcccttgcct tgcttggaga gaaattggca acaaaaaacc attatatgct gtacaagaat gagattttag atggagactc caaaaatatt atccggtcta aagtggagtt gtcagtctgg actgctacct gccaagatgg ggtatcctat attggggaca cggcatcttt tgaagtatca acggagcatg tgtttgccct gcggccggtg ctgtacgcct gcctcctggg gctctgcgcg 60 tgcactagtg gaagtgccac ctcatgtgaa 120 tggtgctcca aagaggactt cggaagccca 180 gcaaaccttg tcaaaaatgg ctgtggaggt 240 gtcctgagga gcctgcccct cagcagcaag 300 cagatgacac cacaggagat tgccgtgaac 360 ctacaggttc gccaggtgga ggactatcct 420 ctgtccatga aggatgactt ggacaatatc 480 atgaggaagc tcaccagcaa cttccggttg 540 tctcctttct cctacacggc accgaggtac 600 tttccaaatt gcgtcccctc ctttgggttc 660 gacagcttca atgaggaagt tcggaaacag 720 gggggctttg atgcagtact ccaggcagcc 780 gatgcactgc atttgctggt gttcacaaca 840 aaattgggag gcctggtgca gccacacgat 900 tacacagcat ccaaccagat ggactatcca 960 gagaacaaca tcaacctcat ctttgcagtg 1020 tttacagccc tgatacctgg aacaacggtg 1080 attcaactga ttattaatgc atacaatagt 1140 gatcagcctg aggatcttaa tctcttcttt 1200 cctggtcaga ggaagtgtga gggtctgaag 1260 ttggaggccc gaagctgtcc cagcagacac 1320 ggattccggg acagcctgga ggtgggggtc 1380 acctacaact gcacgtgcgg ctgcagcgtg gggctggaac ccaacagcgc caggtgcaac 1440 ccggctacct gggcaccagg 1500 acctgtgccg ggaggcagag 1560 accagtgctc ctgcttcgag 1620 acaacttctc ctgtgccagg 1680 gcggggaatg caagtgccat 1740 tcagcacatg ccggggcaga 1800 ggcagtgcca atgcacggag 1860 gcccggatgc atgcagcacc 1920 aacctgacaa ccagacctgc 1980 ccatcgtgaa agatgaccag 2040 tcatgatgtt cacctatgtg 2100 agccagagtg tggaaacacc 2160 tcctccttgt tgggcttgca 2220 ggagggagtt tgcaaagttt 2280 atccattata cagaaagcct 2340 acaaatccta caatggcact 2400 2409 gggagcggga cctatgtctg cggcctgtgt gagtgcagcc tgcgagtgcc aggatgggga gaaccagagc gtgtaccaga ggcaagccac tgtgcagcgg gcgtggggac tgcagctgca agcgagtttg gcaagatcta tgggcctttc tgtgagtgcg aacaagggag tcctctgctc aggccatggc gagtgtcact gcaggttaca tcggggacaa ctgtaactgc tcgacagaca gatggccaga tctgcagcga gcgtgggcac tgtctctgtg ccgggggcct ttggggagat gtgtgagaag tgccccacct aagagagatt gcgtcgagtg cctgctgctc cactctggga cacagcctat gcagggatga ggtgatcaca tgggtggaca gaggctgtgc tatgtttcta caaaaccgcc aaggactgcg gagctcccca gtgggaagtc caacctgacc gtcctcaggg cccaacgcca tgaccatcct cctggctgtg gtcggtagca ctcctggcta tctggaagct gcttgtcacc atccacgacc cagagcgagc gatccagggc ccgctatgaa atggcttcaa atctccacgc acactgtgga cttcaccttc aacaagttca gtggactga 11 2367 DNA Homo sapiens beta3 integrin NM000212 11 atgcgagcgc ggccgcggcc ccggccgctc tgggcgactg tgctggcgct gggggcgctg 60 gcgggcgttg gcgtaggagg gcccaacatc tgtaccacgc gaggtgtgag ctcctgccag 120 cagtgcctgg ctgtgagccc catgtgtgcc tggtgctctg atgaggccct gcctctgggc 180 tcacctcgct gtgacctgaa ggagaatctg ctgaaggata actgtgcccc agaatccatc 240 gagttcccag tgagtgaggc ccgagtacta gaggacaggc ccctcagcga caagggctct 300 ggagacagct cccaggtcac tcaagtcagt ccccagagga ttgcactccg gctccggcca 360 gatgattcga agaatttctc catccaagtg cggcaggtgg aggattaccc tgtggacatc 420 tactacttga tggacctgtc ttactccatg aaggatgatc tgtggagcat ccagaacctg 480 ggtaccaagc tggccaccca gatgcgaaag ctcaccagta acctgcggat tggcttcggg 540 gcatttgtgg acaagcctgt gtcaccatac atgtatatct ccccaccaga ggccctcgaa 600 aacccctgct atgatatgaa gaccacctgc ttgcccatgt ttggctacaa acacgtgctg 660 acgctaactg accaggtgac ccgcttcaat gaggaagtga agaagcagag tgtgtcacgg 720 aaccgagatg ccccagaggg tggctttgat gccatcatgc aggctacagt ctgtgatgaa 780 aagattggct ggaggaatga tgcatcccac ttgctggtgt ttaccactga tgccaagact 840 catatagcat tggacggaag gctggcaggc attgtccagc ctaatgacgg gcagtgtcat 900 gttggtagtg acaatcatta ctctgcctcc actaccatgg attatccctc tttggggctg 960 atgactgaga agctatccca gaaaaacatc aatttgatct ttgcagtgac tgaaaatgta 1020 gtcaatctct atcagaacta tagtgagctc atcccaggga ccacagttgg ggttctgtcc 1080 atggattcca gcaatgtcct ccagctcatt gttgatgctt atgggaaaat ccgttctaaa 1140 gtagagctgg aagtgcgtga cctccctgaa gagttgtctc tatccttcaa tgccacctgc 1200 ctcaacaatg aggtcatccc tggcctcaag tcttgtatgg gactcaagat tggagacacg 1260 gtgagcttca gcattgaggc caaggtgcga ggctgtcccc aggagaagga gaagtccttt 1320 accataaagc ccgtgggctt caaggacagc ctgatcgtcc aggtcacctt tgattgtgac 1380 tgtgcctgcc aggcccaagc tgaacctaat agccatcgct gcaacaatgg caatgggacc 1440 tttgagtgtg gggtatgccg ttgtgggcct ggctggctgg gatcccagtg tgagtgctca 1500 gaggaggact atcgcccttc ccagcaggac gaatgcagcc cccgggaggg tcagcccgtc 1560 tgcagccagc ggggcgagtg cctctgtggt caatgtgtct gccacagcag tgactttggc 1620 aagatcacgg gcaagtactg cgagtgtgac gacttctcct gtgtccgcta caagggggag 1680 atgtgctcag gccatggcca gtgcagctgt ggggactgcc tgtgtgactc cgactggacc 1740 ggctactact gcaactgtac cacgcgtact gacacctgca tgtccagcaa tgggctgctg 1800 tgcagcggcc gcggcaagtg tgaatgtggc agctgtgtct gtatccagcc gggctcctat 1860 ggggacacct gtgagaagtg ccccacctgc ccagatgcct gcacctttaa gaaagaatgt 1920 gtggagtgta agaagtttga ccgggagccc tacatgaccg aaaatacctg caaccgttac 1980 tgccgtgacg agattgagtc agtgaaagag cttaaggaca ctggcaagga tgcagtgaat 2040 tgtacctata agaatgagga tgactgtgtc gtcagattcc agtactatga agattctagt 2100 ggaaagtcca tcctgtatgt ggtagaagag ccagagtgtc ccaagggccc tgacatcctg 2160 gtggtcctgc tctcagtgat gggggccatt ctgctcattg gccttgccgc cctgctcatc 2220 tggaaactcc tcatcaccat ccacgaccga aaagaattcg ctaaatttga ggaagaacgc 2280 gccagagcaa aatgggacac agccaacaac ccactgtata aagaggccac gtctaccttc 2340 accaatatca cgtaccgggg cacttaa 2367 12 3147 DNA Homo sapiens alpha v intergrin NM0022210 12 atggcttttc cgccgcggcg acggctgcgc ctcggtcccc gcggcctccc gcttcttctc 60 tcgggactcc tgctacctct gtgccgcgcc ttcaacctag acgtggacag tcctgccgag 120 tactctggcc ccgagggaag ttacttcggc ttcgccgtgg atttcttcgt gcccagcgcg 180 tcttcccgga tgtttcttct cgtgggagct cccaaagcaa acaccaccca gcctgggatt 240 gtggaaggag ggcaggtcct caaatgtgac tggtcttcta cccgccggtg ccagccaatt 300 gaatttgatg caacaggcaa tagagattat gccaaggatg atccattgga atttaagtcc 360 catcagtggt ttggagcatc tgtgaggtcg aaacaggata aaattttggc ctgtgcccca 420 ttgtaccatt ggagaactga gatgaaacag gagcgagagc ctgttggaac atgctttctt 480 caagatggaa caaagactgt tgagtatgct ccatgtagat cacaagatat tgatgctgat 540 ggacagggat tttgtcaagg aggattcagc attgatttta ctaaagctga cagagtactt 600 cttggtggtc ctggtagctt ttattggcaa ggtcagctta tttcggatca agtggcagaa 660 atcgtatcta aatacgaccc caatgtttac agcatcaagt ataataacca attagcaact 720 cggactgcac aagctatttt tgatgacagc tatttgggtt attctgtggc tgtcggagat 780 ttcaatggtg atggcataga tgactttgtt tcaggagttc caagagcagc aaggactttg 840 ggaatggttt atatttatga tgggaagaac atgtcctcct tatacaattt tactggcgag 900 cagatggctg catatttcgg attttctgta gctgccactg acattaatgg agatgattat 960 gcagatgtgt ttattggagc acctctcttc atggatcgtg gctctgatgg caaactccaa 1020 gaggtggggc aggtctcagt gtctctacag agagcttcag gagacttcca gacgacaaag 1080 ctgaatggat ttgaggtctt tgcacggttt ggcagtgcca tagctccttt gggagatctg 1140 gaccaggatg gtttcaatga tattgcaatt gctgctccat atgggggtga agataaaaaa 1200 ggaattgttt atatcttcaa tggaagatca acaggcttga acgcagtccc atctcaaatc 1260 cttgaagggc agtgggctgc tcgaagcatg ccaccaagct ttggctattc aatgaaagga 1320 gccacagata tagacaaaaa tggatatcca gacttaattg taggagcttt tggtgtagat 1380 cgagctatct tatacagggc cagaccagtt atcactgtaa atgctggtct tgaagtgtac 1440 cctagcattt taaatcaaga caataaaacc tgctcactgc ctggaacagc tctcaaagtt 1500 tcctgtttta atgttaggtt ctgcttaaag gcagatggca aaggagtact tcccaggaaa 1560 cttaatttcc aggtggaact tcttttggat aaactcaagc aaaagggagc aattcgacga 1620 gcactgtttc tctacagcag gtccccaagt cactccaaga acatgactat ttcaaggggg 1680 ggactgatgc agtgtgagga attgatagcg tatctgcggg atgaatctga atttagagac 1740 aaactcactc caattactat ttttatggaa tatcggttgg attatagaac agctgctgat 1800 acaacaggct tgcaacccat tcttaaccag ttcacgcctg ctaacattag tcgacaggct 1860 cacattctac ttgactgtgg tgaagacaat gtctgtaaac ccaagctgga agtttctgta 1920 gatagtgatc aaaagaagat ctatattggg gatgacaacc ctctgacatt gattgttaag 1980 gctcagaatc aaggagaagg tgcctacgaa gctgagctca tcgtttccat tccactgcag 2040 gctgatttca tcggggttgt ccgaaacaat gaagccttag caagactttc ctgtgcattt 2100 aagacagaaa accaaactcg ccaggtggta tgtgaccttg gaaacccaat gaaggctgga 2160 actcaactct tagctggtct tcgtttcagt gtgcaccagc agtcagagat ggatacttct 2220 gtgaaatttg acttacaaat ccaaagctca aatctatttg acaaagtaag cccagttgta 2280 tctcacaaag ttgatcttgc tgttttagct gcagttgaga taagaggagt ctcgagtcct 2340 gatcatatct ttcttccgat tccaaactgg gagcacaagg agaaccctga gactgaagaa 2400 gatgttgggc cagttgttca gcacatctat gagctgagaa acaatggtcc aagttcattc 2460 agcaaggcaa tgctccatct tcagtggcct tacaaatata ataataacac tctgttgtat 2520 atccttcatt atgatattga tggaccaatg aactgcactt cagatatgga gatcaaccct 2580 ttgagaatta agatctcatc tttgcaaaca actgaaaaga atgacacggt tgccgggcaa 2640 ggtgagcggg accatctcat cactaagcgg gatcttgccc tcagtgaagg agatattcac 2700 actttgggtt gtggagttgc tcagtgcttg aagattgtct gccaagttgg gagattagac 2760 agaggaaaga gtgcaatctt gtacgtaaag tcattactgt ggactgagac ttttatgaat 2820 aaagaaaatc agaatcattc ctattctctg aagtcgtctg cttcatttaa tgtcatagag 2880 tttccttata agaatcttcc aattgaggat atcaccaact ccacattggt taccactaat 2940 gtcacctggg gcattcagcc agcgcccatg cctgtgcctg tgtgggtgat cattttagca 3000 gttctagcag gattgttgct actggctgtt ttggtatttg taatgtacag gatgggcttt 3060 tttaaacggg tccggccacc tcaagaagaa caagaaaggg agcagcttca acctcatgaa 3120 aatggtgaag gaaactcaga aacttaa 3147 13 402 DNA Homo sapiens CaSm (cancer associated SM-like oncogene) AF000177 13 atgaactata tgcctggcac cgccagcctc atcgaggaca ttgacaaaaa gcacttggtt 60 ctgcttcgag atggaaggac acttataggc tttttaagaa gcattgatca atttgcaaac 120 ttagtgctac atcagactgt ggagcgtatt catgtgggca aaaaatacgg tgatattcct 180 cgagggattt ttgtggtcag aggagaaaat gtggtcctac taggagaaat agacttggaa 240 aaggagagtg acacacccct ccagcaagta tccattgaag aaattctaga agaacaaagg 300 gtggaacagc agaccaagct ggaagcagag aagttgaaag tgcaggccct gaaggaccga 360 ggtctttcca ttcctcgagc agatactctt gatgagtact aa 402 14 1923 DNA Homo sapiens c-myb NM005375 14 atggcccgaa gaccccggca cagcatatat agcagtgacg aggatgatga ggactttgag 60 atgtgtgacc atgactatga tgggctgctt cccaagtctg gaaagcgtca cttggggaaa 120 acaaggtgga cccgggaaga ggatgaaaaa ctgaagaagc tggtggaaca gaatggaaca 180 gatgactgga aagttattgc caattatctc ccgaatcgaa cagatgtgca gtgccagcac 240 cgatggcaga aagtactaaa ccctgagctc atcaagggtc cttggaccaa agaagaagat 300 cagagagtga tagagcttgt acagaaatac ggtccgaaac gttggtctgt tattgccaag 360 cacttaaagg ggagaattgg aaaacaatgt agggagaggt ggcataacca cttgaatcca 420 gaagttaaga aaacctcctg gacagaagag gaagacagaa ttatttacca ggcacacaag 480 agactgggga acagatgggc agaaatcgca aagctactgc ctggacgaac tgataatgct 540 atcaagaacc actggaattc tacaatgcgt cggaaggtcg aacaggaagg ttatctgcag 600 gagtcttcaa aagccagcca gccagcagtg gccacaagct tccagaagaa cagtcatttg 660 atgggttttg ctcaggctcc gcctacagct caactccctg ccactggcca gcccactgtt 720 aacaacgact attcctatta ccacatttct gaagcacaaa atgtctccag tcatgttcca 780 taccctgtag cgttacatgt aaatatagtc aatgtccctc agccagctgc cgcagccatt 840 cagagacact ataatgatga agaccctgag aaggaaaagc gaataaagga attagaattg 900 ctcctaatgt caaccgagaa tgagctaaaa ggacagcagg tgctaccaac acagaaccac 960 acatgcagct accccgggtg gcacagcacc accattgccg accacaccag acctcatgga 1020 gacagtgcac ctgtttcctg tttgggagaa caccactcca ctccatctct gccagcggat 1080 cctggctccc tacctgaaga aagcgcctcg ccagcaaggt gcatgatcgt ccaccagggc 1140 accattctgg ataatgttaa gaacctctta gaatttgcag aaacactcca atttatagat 1200 tctttcttaa acacttccag taaccatgaa aactcagact tggaaatgcc ttctttaact 1260 tccacccccc tcattggtca caaattgact gttacaacac catttcatag agaccagact 1320 gtgaaaactc aaaaggaaaa tactgttttt agaaccccag ctatcaaaag gtcaatctta 1380 gaaagctctc caagaactcc tacaccattc aaacatgcac ttgcagctca agaaattaaa 1440 tacggtcccc tgaagatgct acctcagaca ccctctcatc tagtagaaga tctgcaggat 1500 gtgatcaaac aggaatctga tgaatctgga tttgttgctg agtttcaaga aaatggacca 1560 cccttactga agaaaatcaa acaagaggtg gaatctccaa ctgataaatc aggaaacttc 1620 ttctgctcac accactggga aggggacagt ctgaataccc aactgttcac gcagacctcg 1680 cctgtgcgag atgcaccgaa tattcttaca agctccgttt taatggcacc agcatcagaa 1740 gatgaagaca atgttctcaa agcatttaca gtacctaaaa acaggtccct ggcgagcccc 1800 ttgcagcctt gtagcagtac ctgggaacct gcatcctgtg gaaagatgga ggagcagatg 1860 acatcttcca gtcaagctcg taaatacgtg aatgcattct cagcccggac gctggtcatg 1920 tga 1923 15 544 DNA Homo sapiens c-myc J00120 15 gacccccgag ctgtgctgct cgcggccgcc accgccgggc cccggccgtc cctggctccc 60 ctcctgcctc gagaagggca gggcttctca gaggcttggc gggaaaaaga acggagggag 120 ggatcgcgct gagtataaaa gccggttttc ggggctttat ctaactcgct gtagtaattc 180 cagcgagagg cagagggagc gagcgggcgg ccggctaggg tggaagagcc gggcgagcag 240 agctgcgctg cgggcgtcct gggaagggag atccggagcg aatagggggc ttcgcctctg 300 gcccagccct cccgctgatc ccccagccag cggtccgcaa cccttgccgc atccacgaaa 360 ctttgcccat agcagcgggc gggcactttg cactggaact tacaacaccc gagcaaggac 420 gcgactctcc cgacgcgggg aggctattct gcccatttgg ggacacttcc ccgccgctgc 480 caggacccgc ttctctgaaa ggctctcctt gcagctgctt agacgctgga tttttttcgg 540 Stag 544 16 618 DNA Homo sapiens ephrin-Al NM004428 16 atggagttcc cacaccgtct gtgcagctga gacgctgcca cagccccagt ccggagaagc aaagaaggac ttgaggttga ccacaggaga cacagtgctg ctgctgcaaa tctgggcccc tctggaacag atgactacgt tggagcagta ccaaggacca tgtctgagaa acagctacta aggtgactgt agagacttgc ccccacgcct ccccgtga tctcttgggt ttcaaatccc ggacatcatc catactgtac agtccgctgg gttccagcgc ctacatctcc cagtggcaaa agcagatgac cttcccactt ctgtgctgca aagttccgga tgtccgcact ctggtggagc cagtgcaacc ttcacacctt aaacccatcc atcactcaca ccagaggtgc gcctggactg gtctggccgc atgaggacta atgaagatca atgaggagta ggcccagtgc tcaccctggg accagcatga gtcctcaggc gggttctaca tgctgctcct tgctgatcgc 60 caccatacat 120 ctctgtggca 180 ccagctgtgc 240 caagcatggc 300 caaggagttc 360 agaccgctgc 420 ccatgtcaat 480 tagcatcggt 540 tccacttctg 600 618 17 642 DNA Homo sapiens 17 atggcgcccg cgcagcgccc gctgctcccg ctgctgctcc tgctgttacc gctgccgccg 60 ccgcccttcg cgcgcgccga ggacgccgcc tggaaccgca gcaaccccag gttccacgca gtggaggtga gcatcaatga ctacctggac ccgccggccg agcgcatgga gcactacgtg tcctgcgacc accgccagcg cggcttcaag ggggggccgc tcaagttctc ggagaagttc gagttccggc ccggccacga gtattactac cggccctgcc tgcgactgaa ggtgtacgtg cctgagccca tcttcaccag caataactcg ctcagcacca tccccgtgct ctggaccctc 18 717 DNA Homo sapiens ephrin-A3 XM001787 18 atggcggcgg ctccgctgct gctgctgctg ctggcccaag ggcccggagg ggcgctggga aaccagcacc tgcggcgaga gggctacacc atttactgcc cgcactacaa cagctcgggg ggcggggcag agcagtacgt gctgtacatg gccagccagg gcttcaagcg ctgggagtgc aagttctcgg agaagttcca gcgctacagc ggccacgagt actactacat ctccacgccc atgaaggtgt tcgtctgctg cgcctccaca ctcccccagt tcaccatggg ccccaatatg cgcgccaact cggaccgcta cgccgtctac 120 ggcgcggggg acgacggcgg gggctacacg 180 atctactgcc cgcactatgg ggcgccgctg 240 ctgtacatgg tcaacggcga gggccacgcc 300 cgctgggagt gcaaccggcc cgcggcgccc 360 cagctcttca cgcccttctc cctgggcttc 420 atctctgcca cgcctcccaa tgctgtggac 480 cggccgacca acgagaccct gtacgaggct 540 tgtagcagcc cgggcggctg ccgcctcttc 600 ctgggttcct ag 642 ctgctcgtgc ccgtgccgct gctgccgctg 60 aaccggcatg cggtgtactg gaacagctcc 120 gtgcaggtga acgtgaacga ctatctggat 180 gtgggccccg gggcgggacc ggggcccgga 240 gtgagccgca acggctaccg cacctgcaac 300 aaccggccgc acgccccgca cagccccatc 360 gccttctctc tgggctacga gttccacgcc 420 actcacaacc tgcactggaa gtgtctgagg 480 tcgcactccg gggagaagcc ggtccccact 540 aagatcaacg tgctggaaga ctttgaggga 600 gagaaccctc aggtgcccaa gcttgagaag agcatcagcg ggaccagccc caaacgggaa 660 cacctgcccc tggccgtggg catcgccttc ttcctcatga cgttcttggc ctcctag 717 19 606 DNA Homo sapiens ephrin-A3 XM001784 19 atgcggctgc tgcccctgct cgcgggggct ccagcctccg cgaggagacg ccgtggtgga tacgaaggcc cagggccccc ccaggctatg agtcctgcca ctgccctttg gccatgttca ggctttgagt tcttacctgg tctggccagt gcttgaggct gcccatcctg ttgggagccc cccagccccc tctgtctctt ctgtga 20 687 DNA Homo sapiens gcggactgtc ccacgtagtc gctgggcctc tgagggcccc ggcagagggc attctcagag agagacttac ccaggtgtct tggagagagt gctattactg ctctgggccg tactggaact aacgattacc gagacgtttg ccccgggcct aagattcagc tactacatct gtctgctgca ggcacatcag ctgcttctga cgttcctcgg ccagtaaccc tagacattgt ctttgtacat acaagcgctg gcttcacacc cggtgcccac aggagaggaa ggtggcgagg ttcttcgtct ctcccctctg 60 caggttgctt 120 ctgcccccac 180 ggtggactgg 240 ggtgtgctcc 300 cttctccctc 360 tccagagagt 420 gtctgagtca 480 gggggacact 540 tctgcgaatt 600 606 ephrin-A5 NM001962 20 atgttgcacg tggagatgtt gacgctggtg caggacccgg gctccaaggc cgtcgccgac cccagattcc agaggggtga ctaccatatt ttctgccctc actatgagga ctccgtccca atggtgaact ttgatggcta cagtgcctgc gaatgtaacc ggcctcactc tccaaatgga ttcactccct tttctctagg atttgaattc tctgcaatcc cagataatgg aagaaggtcc acaaatagct gtatgaaaac tataggtgtt gtagaaaatt cattagaacc agcagatgac ggcgagaacg cggcacaaac accaaggata ctcctggcga tgcttttgac attatag tttctggtgc tctggatgtg tgtgttcagc 60 cgctacgctg tctactggaa cagcagcaac 120 gatgtctgta tcaatgacta cctggatgtt 180 gaagataaga ctgagcgcta tgtcctctac 240 gaccacactt ccaaagggtt caagagatgg 300 ccgctgaagt tctctgaaaa attccagctc 360 aggccaggcc gagaatattt ctacatctcc 420 tgtctaaagc tcaaagtctt tgtgagacca 480 catgatcgtg ttttcgatgt taacgacaaa 540 accgtacatg agtcagccga gccatcccgc 600 cccagccgcc ttttggcaat cctactgttc 660 687 21 2955 DNA Homo sapiens 21 atggccctgg attatctact actgctcctc acgttaatgg acaccagaac ggctactgca gggtgggaag aagtcagtgg ctacgatgaa tgcaatgtct tcgagcccaa ccagaacaat ggggcccatc gcatctacac agagatgcgc aatgtcccag gatcctgcaa ggagaccttc attgccacca agaagtcagc cttctggtct gctgcagatg agagcttctc ccaggtggac gaagtcagga gctttgggcc tcttactcgg ctggcatccg cagtggctgc gatggaagaa 60 gagctgggct ggacggccaa tcctgcgtcc 120 aacctgaaca ccatccgcac ctaccaggtg 180 tggctgctca ccaccttcat caaccggcgg 240 ttcactgtga gagactgcag cagcctccct 300 aacttgtatt actatgagac tgactctgtc 360 gaggccccct acctcaaagt agacaccatt 420 tttgggggaa ggctgatgaa ggtaaacaca 480 aatggttttt acctcgcttt tcaggattat 540 ggagcctgta tgtctcttct ttctgtccgt gtcttcttca aaaagtgtcc cagcattgtg 600 caaaattttg cagtgtttcc agagactatg acaggggcag agagcacatc tctggtgatt 660 gctcggggca catgcatccc caacgcagag gaagtggacg tgcccatcaa actctactgc 720 aacggggatg gggaatggat ggtgcctatt gggcgatgca cctgcaagcc tggctatgag 780 cctgagaaca gcgtggcatg caaggcttgc cctgcaggga cattcaaggc cagccaggaa 840 gctgaaggct gctcccactg cccctccaac agccgctccc ctgcagaggc gtctcccatc 900 tgcacctgtc ggaccggtta ttaccgagcg gactttgacc ctccagaagt ggcatgcact 960 agcgtcccat caggtccccg caatgttatc tccatcgtca atgagacgtc catcattctg 1020 gagtggcacc ctccaaggga gacaggtggg cgggatgatg tgacctacaa catcatctgc 1080 aaaaagtgcc gggcagaccg ccggagctgc tcccgctgtg acgacaatgt ggagtttgtg 1140 cccaggcagc tgggcctgac ggagtgccgc gtctccatca gcagcctgtg ggcccacacc 1200 ccctacacct ttgacatcca ggccatcaat ggagtctcca gcaagagtcc cttcccccca 1260 cagcacgtct ctgtcaacat caccacaaac caagccgccc cctccaccgt tcccatcatg 1320 caccaagtca gtgccactat gaggagcatc accttgtcat ggccacagcc ggagcagccc 1380 aatggcatca tcctggacta tgagatccgg tactatgaga aggaacacaa tgagttcaac 1440 tcctccatgg ccaggagtca gaccaacaca gcaaggattg atgggctgcg gcctggcatg 1500 gtatatgtgg tacaggtgcg tgcccgcact gttgctggct acggcaagtt cagtggcaag 1560 atgtgcttcc agactctgac tgacgatgat tacaagtcag agctgaggga gcagctgccc 1620 ctgattgctg gctcggcagc ggccggggtc gtgttcgttg tgtccttggt ggccatctct 1680 atcgtctgta gcaggaaacg ggcttatagc aaagaggctg tgtacagcga taagctccag 1740 cattacagca caggccgagg ctccccaggg atgaagatct acattgaccc cttcacttat 1800 gaggatccca acgaagctgt ccgggagttt gccaaggaga ttgatgtatc ttttgtgaaa 1860 attgaagagg tcatcggagc aggggagttt ggagaagtgt acaaggggcg tttgaaactg 1920 ccaggcaaga gggaaatcta cgtggccatc aagaccctga aggcagggta ctcggagaag 1980 cagcgtcggg actttctgag tgaggcgagc atcatgggcc agttcgacca tcctaacatc 2040 attcgcctgg agggtgtggt caccaagagt cggcctgtca tgatcatcac agagttcatg 2100 gagaatggtg cattggattc tttcctcagg caaaatgacg ggcagttcac cgtgatccag 2160 cttgtgggta tgctcagggg catcgctgct ggcatgaagt acctggctga gatgaattat 2220 gtgcatcggg acctggctgc taggaacatt ctggtcaaca gtaacctggt gtgcaaggtg 2280 tccgactttg gcctctcccg ctacctccag gatgacacct cagatcccac ctacaccagc 2340 tccttgggag ggaagatccc tgtgagatgg acagctccag aggccatcgc ctaccgcaag 2400 ttcacttcag ccagcgacgt ttggagctat ggagagagac cctattggga tatgtccaac taccggctgc ccccacccat ggactgtcca tggcagaagg accggaacag ccggccccgg atgatccgga acccggcaag tctcaagact cccctgctcg accgctccat cccagacttc agcgccatca aaatggtcca gtacagggac cagctggtca cccagatgac atcagaagac catcagaaga agatcctgaa cagcattcat acggcaatgg catga 22 3168 DNA Homo sapiens gggatcgtca tgtgggaagt catgtcattt 2460 caagatgtca tcaatgccat cgagcaggac 2520 gctgctctac accagctcat gctggactgt 2580 tttgcggaga ttgtcaacac cctagataag 2640 gtggcaacca tcaccgccgt gccttcccag 2700 acggccttta ccaccgtgga tgactggctc 2760 agcttcctca ctgctggctt cacctccctc 2820 ctcctgagaa taggcatcac cttggcaggc 2880 tctatgaggg tccagataag tcagtcacca 2940 2955 22 atggctctgc ggaggctggg ggccgcgctg gaaacgctaa tggactccac tacagcgact teagggtggg aagaggtgag tggctacgat gtgtgcaacg tgtttgagtc aagccagaac cgtggcgccc accgcatcca cgtggagatg cccagcgtgc ctggctcctg caaggagacc gactcggcca ccaagacctt ccccaactgg attgcagccg acgagagctt ctcccaggtg accgaggtgc ggagcttcgg acctgtgtcc tatggcggct gcatgtccct catcgccgtg atccagaatg gcgccatctt ccaggaaacc gctgcccggg gcagctgcat cgccaatgcg tgtaacgggg acggcgagtg gctggtgccc gaggccgttg agaatggcac cgtctgccga ctgctgctgc cgctgctcgc cgccgtggaa 60 gctgagctgg gctggatggt gcatcctcca 120 gagaacatga acacgatccg cacgtaccag 180 aactggctac ggaccaagtt tatccggcgc 240 aagttttcgg tgcgtgactg cagcagcatc 300 ttcaacctct attactatga ggctgacttt 360 atggagaatc catgggtgaa ggtggatacc 420 gacctgggtg gccgcgtcat gaaaatcaac 480 cgcagcggct tctacctggc cttccaggac 540 cgtgtcttct accgcaagtg cccccgcatc 600 ctgtcggggg ctgagagcac atcgctggtg 660 gaagaggtgg atgtacccat caagctctac 720 atcgggcgct gcatgtgcaa agcaggcttc 780 ggttgtccat ctgggacttt caaggccaac 840 caaggggatg aggcctgtac ccactgtccc atcaacagcc ggaccacttc tgaaggggcc 900 accaactgtg tctgccgcaa tggctactac agagcagacc tggaccccct ggacatgccc 960 tgcacaacca tcccctccgc gccccaggct gtgatttcca gtgtcaatga gacctccctc 1020 atgctggagt ggacccctcc ccgcgactcc ggaggccgag aggacctcgt ctacaacatc 1080 atctgcaaga gctgtggctc gggccggggt gcctgcaccc gctgcgggga caatgtacag 1140 tacgcaccac gccagctagg cctgaccgag ccacgcattt acatcagtga cctgctggcc 1200 cacacccagt acaccttcga gatccaggct gtgaacggcg ttactgacca gagccccttc 1260 tcgcctcagt tcgcctctgt gaacatcacc accaaccagg cagctccatc ggcagtgtcc 1320 atcatgcatc aggtgagccg caccgtggac agcattaccc tgfrgtggtc ccagccagac 1380 cagcccaatg gcgtgatcct ggactatgag ctgcagtact atgagaagga gctcagtgag 1440 tacaacgcca cagccataaa aagccccacc aacacggtca ccgtgcaggg cctcaaagcc 1500 ggcgccatct atgtcttcca ggtgcgggca cgcaccgtgg caggctacgg gcgctacagc 1560 ggcaagatgt acttccagac catgacagaa gccgagtacc agacaagcat ccaggagaag 1620 ttgccactca tcatcggctc ctcggccgct ggcctggtct tcctcattgc tgtggttgte 1680 atcgccatcg tgtgtaacag acgggggttt gagcgtgctg actcggagta cacggacaag 1740 ctgcaacact acaccagtgg ccacatgacc ccaggcatga agatctacat cgatcctttc 1800 acctacgagg accccaacga ggcagtgcgg gagtttgcca aggaaattga catctcctgt 1860 gtcaaaattg agcaggtgat cggagcaggg gagtttggcg aggtctgcag tggccacctg 1920 aagctgccag gcaagagaga gatctttgtg gccatcaaga cgctcaagtc gggctacacg 1980 gagaagcagc gccgggactt cctgagcgaa gcctccatca tgggccagtt cgaccatccc 2040 aacgtcatcc acctggaggg tgtcgtgacc aagagcacac ctgtgatgat catcaccgag 2100 ttcatggaga atggctccct ggactccttt ctccggcaaa acgatgggca gttcacagtc 2160 atccagctgg tgggcatgct tcggggcatc gcagctggca tgaagtacct ggcagacatg 2220 aactatgttc accgtgacct ggctgcccgc aacatcctcg tcaacagcaa cctggtctgc 2280 aaggtgtcgg actttgggct ctcacgcttt ctagaggacg atacctcaga ccccacctac 2340 accagtgccc tgggcggaaa gatccccatc cgctggacag ccccggaagc catccagtac 2400 cggaagttca cctcggccag tgatgtgtgg agctacggca ttgtcatgtg ggaggtgatg 2460 tcctatgggg agcggcccta ctgggacatg accaaccagg atgtaatcaa tgccattgag 2520 caggactatc ggctgccacc gcccatggac tgcccgagcg ccctgcacca actcatgctg 2580 gactgttggc agaaggaccg caaccaccgg cccaagttcg gccaaattgt caacacgcta 2640 gacaagatga tccgcaatcc caacagcctc aaagccatgg cgcccctctc ctctggcatc 2700 aacctgccgc tgctggaccg cacgatcccc tggctggagg ccatcaagat ggggcagtac tcctttgacg tcgtgtctca gatgatgatg gctggccacc agaaaaaaat cctgaacagt attcagtctg tggagggcca gccactcgcc cggtgccagc cacgagacgt caccaagaaa ggaatgggaa aaaagaaaac agatcctggg aaagaggatt ctcataagga aagcaatgac gactacacca gctttaacac ggtggacgag 2760 aaggagagct tcgccaatgc cggcttcacc 2820 gaggacattc tccgggttgg ggtcactttg 2880 atccaggtga tgcgggcgca gatgaaccag 2940 aggaggccac gggccacggg aagaaccaag 3000 acatgcaact caaacgacgg aaaaaaaaag 3060 agggggcggg aaatacaagg aatatttttt 3120 tgttcttgcg ggggataa 3168 23 2997 DNA Homo sapiens 23 atggccagag cccgcccgcc gccgccgccg cctccgctgc tgctgctgcc gctgctgctg accctcatgg acacaaaatg ggtaacatct gggtgggaag aggtgagtgg ctacgatgag tgtaatgtgc gcgagtcaag ccagaacaac gatgtgcagc gggtctacgt ggagctcaag aacatccccg gctcctgcaa ggagaccttc gtggcctcag cctcctcccc cttctggatg gcacccgatg agagcttctc gcggctggat tttgggccac tttccaaggc tggcttctac tcgctcatct ccgtgcgcgc cttctacaag ctcttccccg agaccctcac tggggcggag tgcatcccta acgccgtgga ggtgteggtg gagtggatgg tgcctgtggg tgcctgcacc gagtcccagt gccgcccctg tccccctggg tgcctcccat gtccccccaa cagccgtacc cacaataact tctaccgtgc agactcggac tcgccgccgc cggggcttct gccgctgctc 60 ctgcccgccg gctgccgggc gctggaagag 120 gagttggcgt ggacatctca tccagaaagt 180 gccatgaatc ccatccgcac ataccaggtg 240 tggcttcgca cggggttcat ctggcggcgg 300 ttcactgtgc gtgactgcaa cagcatcccc 360 aacctcttct actacgaggc tgacagcgat 420 gagaacccct acgtgaaagt ggacaccatt 480 gccggccgtg tcaacaccaa ggtgcgcagc 540 ctggccttcc aggaccaggg cgcctgcatg 600 aagtgtgcat ccaccaccgc aggcttcgca 660 cccacctcgc tggtcattgc tcctggcacc 720 ccactcaagc tctactgcaa cggcgatggg 780 tgtgccaccg gccatgagcc agctgccaag 840 agctacaagg cgaagcaggg agaggggccc 900 acctccccag ccgccagcat ctgcacctgc 960 tctgcggaca gtgcctgtac caccgtgcca 1020 tctccacccc gaggtgtgat ctccaatgtg aatgaaacct cactgatcct cgagtggagt 1080 gagccccggg acctgggtgt ccgggatgac ctcctgtaca atgtcatctg caagaagtgc 1140 catggggctg gaggggcctc agcctgctca cgctgtgatg acaacgtgga gtttgtgcct 1200 cggcagctgg gcctgtcgga gccccgggtc cacaccagcc atctgctggc ccacacgcgc 1260 tacacctttg aggtgcaggc ggtcaacggt gtctcgggca agagccctct gccgcctcgt 1320 tatgcggccg tgaatatcac cacaaaccag gctgccccgt ctgaagtgcc cacactacgc 1380 ctgcacagca gctcaggcag cagcctcacc ctatcctggg cacccccaga gcggcccaac 1440 ggagtcatcc tggactacga gatgaagtac tttgagaaga gcgagggcat cgcctccaca 1500 gtgaccagcc agatgaactc cgtgcagctg gacgggcttc ggcctgacgc ccgctatgtg 1560 gtccaggtcc gtgcccgcac agtagctggc tatgggcagt acagccgccc tgccgagttt 1620 gagaccacaa gtgagagagg ctctggggcc cagcagctcc aggagcagct tcccctcatc 1680 gtgggctccg ctacagctgg gcttgtcttc gtggtggctg tcgtggtcat cgctatcgtc 1740 tgcctcagga agcagcgaca cggctctgat tcggagtaca cggagaagct gcagcagtac 1800 attgctcctg gaatgaaggt ttatattgac ccttttacct acgaggaccc taatgaggct 1860 gttcgggagt ttgccaagga gatcgacgtg tcctgcgtca agatcgagga ggtgatcgga 1920 gctggggaat ttggggaagt gtgccgtggt cgactgaaac agcctggccg ccgagaggtg 1980 tttgtggcca tcaagacgct gaaggtgggc tacaccgaga ggcagcggcg ggacttccta 2040 agcgaggcct ccatcatggg tcagtttgat caccccaata taatccggct cgagggcgtg 2100 gtcaccaaaa gtcggccagt tatgatcctc actgagttca tggaaaactg cgccctggac 2160 tccttcctcc ggctcaacga tgggcagttc acggtcatcc agctggtggg catgttgcgg 2220 ggcattgctg ccggcatgaa gtacctgtcc gagatgaact atgtgcaccg cgacctggct 2280 gctcgcaaca tccttgtcaa cagcaacctg gtctgcaaag tctcagactt tggcctctcc 2340 cgcttcctgg aggatgaccc ctccgatcct acctacacca gttccctggg cgggaagatc 2400 cccatccgct ggactgcccc agaggccata gcctatcgga agttcacttc tgctagtgat 2460 gtctggagct acggaattgt catgtgggag gtcatgagct atggagagcg accctactgg 2520 gacatgagca accaggatgt catcaatgcc gtggagcagg attaccggct gccaccaccc 2580 atggactgtc ccacagcact gcaccagctc atgctggact gcgggtgcg ggaccggaac 2640 ctcaggccca aattctccca gattgtcaat accctggaca agctcatccg caatgctgcc 2700 agcctcaagg tcattgccag cgctcagtct ggcatgtcac agcccctcct ggaccgcacg 2760 gtcccagatt acacaacctt cacgacagtt ggtgattggc tggatgccat caagatgggg 2820 cggtacaagg agagcttcgt cagtgcgggg tttgcatctt ttgacctggt ggcccagatg 2880 acggcagaag acctgctccg tattggggtc accctggccg gccaccagaa gaagatcctg 2940 agcagtatcc aggacatgcg gctgcagatg aaccagacgc tgcctgtgca ggtctga 2997 24 2964 DNA Homo sapiens 24 atggagctcc gggtgctgct ctgctgggct tcgttggccg cagctttgga agagaccctg 60 ctgaacacaa aattggaaac tgctgatctg aagtgggtga cattccctca ggtggacggg 120 cagtgggagg aactgagcgg cctggatgag gaacagcaca gcgtgcgcac ctacgaagtg 180 tgtgaagtgc agcgtgcccc gggccaggcc cactggcttc gcacaggttg ggtcccacgg 240 cggggcgccg tccacgtgta cgccacgctg cgcttcacca tgctcgagtg cctgtccctg 300 cctcgggctg ggcgctcctg caaggagacc ttcaccgtct tctactatga gagcgatgcg 360 gacacggcca cggccctcac gccagcctgg atggagaacc cctacatcaa ggtggacacg 420 gtggccgcgg agcatctcac ccggaagcgc cctggggccg aggccaccgg gaaggtgaat 480 gtcaagacgc tgcgtctggg accgctcagc aaggctggct tctacctggc cttccaggac 540 cagggtgcct gcatggccct gctatccctg cacctcttct acaaaaagtg cgcccagctg 600 actgtgaacc tgactcgatt cccggagact gtgcctcggg agctggttgt gcccgtggcc 660 ggtagctgcg tggtggatgc cgtccccgcc cctggcccca gccccagcct ctactgccgt 720 gaggatggcc agtgggccga acagccggtc acgggctgca gctgtgctcc ggggttcgag 780 gcagctgagg ggaacaccaa gtgccgagcc tgtgcccagg gcaccttcaa gcccctgtca 840 ggagaagggt cctgccagcc atgcccagcc aatagccact ctaacaccat tggatctgcc 900 gtctgccagt gccgcgtcgg ggacttccgg gcacgcacag acccccgggg tgcaccctgc 960 accacccctc cttcggctcc gcggagcgtg gtttcccgcc tgaacggctc ctccctgcac 1020 ctggaatgga gtgcccccct ggagtctggt ggccgagagg acctcaccta cgccctccgc 1080 tgccgggagt gccgacccgg aggctcctgt gcgccctgcg ggggagacct gacttttgac 1140 cccggccccc gggacctggt ggagccctgg gtggtggttc gagggctacg tccggacttc 1200 acctatacct ttgaggtcac tgcattgaac ggggtatcct ccttagccac ggggcccgtc 1260 ccatttgagc ctgtcaatgt caccactgac cgagaggtac ctcctgcagt gtctgacatc 1320 cgggtgacgc ggtcctcacc cagcagcttg agcctggcct gggctgttcc ccgggcaccc 1380 agtggggcgt ggctggacta cgaggtcaaa taccatgaga agggcgccga gggtcccagc 1440 agcgtgcggt tcctgaagac gtcagaaaac cgggcagagc tgcgggggct gaagcgggga 1500 gccagctacc tggtgcaggt acgggcgcgc tctgaggccg gctacgggcc cttcggccag 1560 gaacatcaca gccagaccca actggatgag agcgagggct ggcgggagca gctggccctg 1620 attgcgggca cggcagtcgt gggtgtggtc ctggtcctgg tggtcattgt ggtcgcagtt 1680 ctctgcctca ggaagcagag caatgggaga gaagcagaat attcggacaa acacggacag 1740 tatctcatcg gacatggtac taaggtctac atcgacccct tcacttatga agaccctaat 1800 gaggctgtga gggaatttgc aaaagagatc gatgtctcct acgtcaagat tgaagaggtg 1860 attggtgcag gtgagtttgg cgaggtgtgc cgggggcggc tcaaggcccc agggaagaag 1920 gagagctgtg tggcaatcaa gaccctgaag ggtggctaca cggagcggca gcggcgtgag 1980 tttctgagcg aggcctccat catgggccag ttcgagcacc ccaatatcat ccgcctggag 2040 ggcgtggtca ccaacagcat gcccgtcatg attctcacag agttcatgga gaacggcgcc 2100 ctggactcct tcctgcggct aaacgacgga cagttcacag tcatccagct cgtgggcatg 2160 ctgcggggca tcgcctcggg catgcggtac cttgccgaga tgagctacgt ccaccgagac 2220 ctggctgctc gcaacatcct agtcaacagc aacctcgtct gcaaagtgtc tgactttggc 2280 ctttcccgat tcctggagga gaactcttcc gatcccacct acacgagctc cctgggagga 2340 aagattccca tccgatggac tgccccggag gccattgcct tccggaagtt cacttccgcc 2400 agtgatgcct ggagttacgg gattgtgatg tgggaggtga tgtcatttgg ggagaggccg 2460 tactgggaca tgagcaatca ggacgtgatc aatgccattg aacaggacta ccggctgccc 2520 ccgcccccag actgtcccac ctccctccac cagctcatgc tggactgttg gcagaaagac 2580 cggaatgccc ggccccgctt cccccaggtg gtcagcgccc tggacaagat gatccggaac 2640 cccgccagcc tcaaaatcgt ggcccgggag aatggcgggg cctcacaccc tctcctggac 2700 cagcggcagc ctcactactc agcttttggc tctgtgggcg agtggcttcg ggccatcaaa 2760 atgggaagat acgaagcccg tttcgcagcc gctggctttg gctccttcga gctggtcagc 2820 cagatctctg ctgaggacct gctccgaatc ggagtcactc tggcgggaca ccagaagaaa 2880 atcttggcca gtgtccagca catgaagtcc caggccaagc cgggaacccc gggtgggaca 2940 ggaggaccgg ccccgcagta ctga 2964 25 1041 DNA Homo sapiens ephrin-Bl NM004429 25 atggctcggc ctgggcagcg ttggctcggc aagtggcttg tggcgatggt cgtgtgggcg 60 ctgtgccggc tcgccacacc gctggccaag aacctggagc ccgtatcctg gagctccctc 120 aaccccaagt tcctgagtgg gaagggcttg gtgatctatc cgaaaattgg agacaagctg 180 gacatcatct gcccccgagc agaagcaggg cggccctatg agtactacaa gctgtacctg 240 gtgcggcctg agcaggcagc tgcctgtagc acagttctcg accccaacgt gttggtcacc 300 tgcaataggc cagagcagga aatacgcttt accatcaagt tccaggagtt cagccccaac 360 tacatgggcc tggagttcaa gaagcaccat gattactaca ttacctcaac atccaatgga 420 agcctggagg ggctggaaaa ccgggagggc ggtgtgtgcc gcacacgcac catgaagatc 480 atcatgaagg ttgggcaaga tcccaatgct gtgacgcctg agcagctgac taccagcagg 540 cccagcaagg aggcagacaa cactgtcaag atggccacac aggcccctgg tagtcggggc 600 tccctgggtg actctgatgg caagcatgag actgtgaacc aggaagagaa gagtggccca 660 ggtgcaagtg ggggcagcag cggggaccct gatggcttct tcaactccaa ggtggcattg 720 ttcgcggctg tcggtgccgg ttgcgtcatc ttcctgctca tcatcatctt cctgacggtc 780 ctactactga agctacgcaa gcggcaccgc aagcacacac agcagcgggc ggctgccctc 840 tcgctcagta ccctggccag tcccaagggg ggcagtggca cagcgggcac cgagcccagc 900 gacatcatca ttcccttacg gactacagag aacaactact gcccccacta tgagaaggtg 960 agtggggact acgggcaccc tgtctacatc gtccaagaga tgccgcccca gagcccggcg 1020 aacatctact acaaggtctg a 1041 26 1002 DNA Homo sapiens 26 atggctgtga gaagggactc cgtgtggaag tactgctggg gtgttttgat ggttttatgc 60 agaactgcga tttccaaatc gatagtttta gagcctatct attggaattc ctcgaactcc 120 aaatttctac ctggacaagg actggtacta tacccacaga taggagacaa attggatatt 180 atttgcccca aagtggactc taaaactgtt ggccagtatg aatattataa agtttatatg 240 gttgataaag accaagcaga cagatgcact attaagaagg aaaatacccc tctcctcaac 300 tgtgccaaac cagaccaaga tatcaaattc accatcaagt ttcaagaatt cagccctaac 360 ctctggggtc tagaatttca gaagaacaaa gattattaca ttatatctac atcaaatggg 420 tctttggagg gcctggataa ccaggaggga ggggtgtgcc agacaagagc catgaagatc 480 ctcatgaaag ttggacaaga tgcaagttct gctggatcaa ccaggaataa agatccaaca 540 agacgtccag aactagaagc tggtacaaat ggaagaagtt cgacaacaag tccctttgta 600 aaaccaaatc caggttctag cacagacggc aacagcgccg gacattcggg gaacaacatc 660 ctcggttccg aagtggcctt atttgcaggg attgcttcag gatgcatcat cttcatcgtc 720 atcatcatca cgctggtggt cctcttgctg aagtaccgga ggagacacag gaagcactcg 780 ccgcagcaca cgaccacgct gtcgctcagc acactggcca cacccaagcg cagcggcaac 840 aacaacggct cagagcccag tgacattatc atcccgctaa ggactgcgga cagcgtcttc 900 tgccctcact acgagaaggt cagcggcgac tacgggcacc cggtgtacat cgtccaggag 960 atgcccccgc agagcccggc gaacatttac tacaaggtct ga 1002 27 1023 DNA Homo sapiens 27 atggggcccc cccattctgg gccggggggc gtgcgagtcg gggccctgct gctgctgggg 60 gttttggggc tggtgtctgg gctcagcctg gagcctgtct actggaactc ggcgaataag 120 aggttccagg cagagggtgg ttatgtgctg taccctcaga tcggggaccg gctagacctg 180 ctctgccccc gggcccggcc tcctggccct cactcctctc ctaattatga gttctacaag 240 ctgtacctgg tagggggtgc tcagggccgg cgctgtgagg caccccctgc cccaaacctc 300 cttctcactt gtgatcgccc agacctggat ctccgcttca ccatcaagtt ccaggagtat 360 agccctaatc tctggggcca cgagttccgc tcgcaccacg attactacat cattgccaca 420 teggatggga cccgggaggg cctggagagc ctgcagggag gtgtgtgcct aaccagaggc 480 atgaaggtgc ttctccgagt gggacaaagt ccccgaggag gggctgtccc ccgaaaacct 540 gtgtctgaaa tgcccatgga aagagaccga ggggcagccc acagcctgga gcctgggaag 600 gagaacctgc caggtgaccc caccagcaat gcaacctccc ggggtgctga aggccccctg 660 ccccctccca gcatgcctgc agtggctggg gcagcagggg ggctggcgct gctcttgctg 720 ggcgtggcag gggctggggg tgccatgtgt tggcggagac ggcgggccaa gccttcggag 780 agtcgccacc ctggtcctgg ctccttcggg aggggagggt ctctgggcct ggggggtgga 840 ggtgggatgg gacctcggga ggctgagcct ggggagctag ggatagctct gcggggtggc 900 ggggctgcag atcccccctt ctgcccccac tatgagaagg tgagtggtga ctatgggcat 960 cctgtgtata tcgtgcagga tgggcccccc cagagccctc caaacatcta ctacaaggta 1020 tga 1023 28 3399 DNA Homo sapiens telomerase reverse transcriptase AF015950 ccgagccgtg cgctccctgc tgcgcagcca ctaccgcgag 60 cgtgcggcgc ctggggcccc agggctggcg gctggtgcag 120 ccgcgcgctg gtggcccagt gcctggtgtg cgtgccctgg 180 cgccccctcc ttccgccagg tgtcctgcct gaaggagctg 240 gctgtgcgag cgcggcgcga agaacgtgct ggccttcggc 300 28 atgccgcgcg ctccccgctg gtgctgccgc tggccacgtt cgcggggacc cggcggcttt gacgcacggc cgccccccgc gtggcccgag tgctgcagag ttcgcgctgc tggacggggc ccgcgggggc ccccccgagg ccttcaccac cagcgtgcgc 360 agctacctgc ccaacacggt gaccgacgca ctgcggggga gcggggcgtg ggggctgctg 420 ctgcgccgcg tgggcgacga cgtgctggtt cacctgctgg cacgctgcgc gctctttgtg 480 ctggtggctc ccagctgcgc ctaccaggtg tgcgggccgc cgctgtacca gctcggcgct 540 gccactcagg cccggccccc gccacacgct agtggacccc gaaggcgtct gggatgcgaa 600 cgggcctgga accatagcgt cagggaggcc ggggtccccc tgggcctgcc agccccgggt 660 gcgaggaggc gcgggggcag tgccagccga agtctgccgt tgcccaagag gcccaggcgt 720 ggcgctgccc ctgagccgga gcggacgccc gttgggcagg ggtcctgggc ccacccgggc 780 aggacgcgtg gaccgagtga ccgtggtttc tgtgtggtgt cacctgccag acccgccgaa 840 gaagccacct ctttggaggg tgcgctctct ggcacgcgcc actcccaccc atccgtgggc 900 cgccagcacc acgcgggccc cccatccaca tcgcggccac cacgtccctg ggacacgcct 960 tgtcccccgg tgtacgccga gaccaagcac ttcctctact cctcaggcga caaggagcag 1020 ctgcggccct ccttcctact cagctctctg aggcccagcc tgactggcgc tcggaggctc 1080 gtggagacca tctttctggg ttccaggccc tggatgccag ggactccccg caggttgccc 1140 cgcctgcccc agcgctactg gcaaatgcgg cccctgtttc tggagctgct tgggaaccac 1200 gcgcagtgcc cctacggggt gctcctcaag acgcactgcc cgctgcgagc tgcggtcacc 1260 ccagcagccg gtgtctgtgc ccgggagaag ccccagggct ctgtggcggc ccccgaggag 1320 gaggacacag acccccgtcg cctggtgcag ctgctccgcc agcacagcag cccctggcag 1380 gtgtacggct tcgtgcgggc ctgcctgcgc cggctggtgc ccccaggcct ctggggctcc 1440 aggcacaacg aacgccgctt cctcaggaac accaagaagt tcatctccct ggggaagcat 1500 gccaagctct cgctgcagga gctgacgtgg aagatgagcg tgcgggactg cgcttggctg 1560 cgcaggagcc caggggttgg ctgtgttccg gccgcagagc accgtctgcg tgaggagatc 1620 ctggccaagt tcctgcactg gctgatgagt gtgtacgtcg tcgagctgct caggtctttc 1680 ttttatgtca cggagaccac gtttcaaaag aacaggctct ttttctaccg gaagagtgtc 1740 tggagcaagt tgcaaagcat tggaatcaga cagcacttga agagggtgca gctgcgggag 1800 ctgtcggaag cagaggtcag gcagcatcgg gaagccaggc ccgccctgct gacgtccaga 1860 ctccgcttca tccccaagcc tgacgggctg cggccgattg tgaacatgga ctacgtcgtg 1920 ggagccagaa cgttccgcag agaaaagagg gccgagcgtc tcacctcgag ggtgaaggca 1980 ctgttcagcg tgctcaacta cgagcgggcg cggcgccccg gcctcctggg cgcctctgtg 2040 ctgggcctgg acgatatcca cagggcctgg cgcaccttcg tgctgcgtgt gcgggcccag 2100 gacccgccgc ctgagctgta ctttgtcaag gtggatgtga cgggcgcgta cgacaccatc 2160 ccccaggaca ggctcacgga ggtcatcgcc agcatcatca aaccccagaa cacgtactgc 2220 gtgcgtcggt atgccgtggt ccagaaggcc gcccatgggc acgtccgcaa ggccttcaag 2280 agccacgtct ctaccttgac agacctccag ccgtacatgc gacagttcgt ggctcacctg 2340 caggagacca gcccgctgag ggatgccgtc gtcatcgagc agagctcctc cctgaatgag 2400 gccagcagtg gcctcttcga cgtcttccta cgcttcatgt gccaccacgc cgtgcgcatc 2460 aggggcaagt cctacgtcca gtgccagggg atcccgcagg gctccatcct ctccacgctg 2520 ctctgcagcc tgtgctacgg cgacatggag aacaagctgt ttgcggggat tcggcgggac 2580 gggctgctcc tgcgtttggt ggatgatttc ttgttggtga cacctcacct cacccacgcg 2640 aaaaccttcc tcaggaccct ggtccgaggt gtccctgagt atggctgcgt ggtgaacttg 2700 cggaagacag tggtgaactt ccctgtagaa gacgaggccc tgggtggcac ggcttttgtt 2760 cagatgccgg cccacggcct attcccctgg tgcggcctgc tgctggatac ccggaccctg 2820 gaggtgcaga gcgactactc cagctatgcc cggacctcca tcagagccag tctcaccttc 2880 aaccgcggct tcaaggctgg gaggaacatg cgtcgcaaac tctttggggt cttgcggctg 2940 aagtgtcaca gcctgtttct ggatttgcag gtgaacagcc tccagacggt gtgcaccaac 3000 atctacaaga tcctcctgct gcaggcgtac aggtttcacg catgtgtgct gcagctccca 3060 tttcatcagc aagtttggaa gaaccccaca tttttcctgc gcgtcatctc tgacacggcc 3120 tccctctgct actccatcct gaaagccaag aacgcaggga tgtcgctggg ggccaagggc 3180 gccgccggcc ctctgccctc cgaggccgtg cagtggctgt gccaccaagc attcctgctc 3240 aagctgactc gacaccgtgt cacctacgtg ccactcctgg ggtcactcag gacagcccag 3300 acgcagctga gtcggaagct cccggggacg acgctgactg ccctggaggc cgcagccaac 3360 ccggcactgc cctcagactt caagaccatc ctggactga 3399 29 567 DNA Homo sapiens K-ras M54968 29 atgactgaat ataaacttgt ggtagttgga gcttgtggcg taggcaagag tgccttgacg 60 atacagctaa ttcagaatca ttttgtggac gaatatgatc caacaataga ggattcctac 120 aggaagcaag tagtaattga tggagaaacc tgtctcttgg atattctcga cacagcaggt 180 caagaggagt acagtgcaat gagggaccag tacatgagga ctggggaggg ctttctttgt 240 gtatttgcca taaataatac taaatcattt gaagatattc accattatag agaacaaatt 300 aaaagagtta aggactctga agatgtacct atggtcctag taggaaataa atgtgatttg 360 ccttctagaa cagtagacac aaaacaggct caggacttag caagaagtta tggaattcct 420 tttattgaaa catcagcaaa gacaagacag ggtgttgatg atgccttcta tacattagtt 480 cgagaaattc gaaaacataa agaaaagatg agcaaagatg gtaaaaagaa gaaaaagaag 540 tcaaagacaa agtgtgtaat tatgtaa 567 30 3840 DNA Homo sapiens mdr-1 AF016535 30 atggatcttg aaggggaccg caatggagga gcaaagaaga agaacttttt taaactgaac 60 aataaaagtg aaaaagataa gaaggaaaag aaaccaactg tcagtgtatt ttcaatgttt 120 cgctattcaa attggcttga caagttgtat atggtggtgg gaactttggc tgccatcatc 180 catggggctg gacttcctct catgatgctg gtgtttggag aaatgacaga tatctttgca 240 aatgcaggaa atttagaaga tctgatgtca aacatcacta atagaagtga tatcaatgat 300 acagggttct tcatgaatct ggaggaagac atgaccaggt atgcctatta ttacagtgga 360 attggtgctg gggtgctggt tgctgcttac attcaggttt cattttggtg cctggcagct 420 ggaagacaaa tacacaaaat tagaaaacag ttttttcatg ctataatgcg acaggagata 480 ggctggtttg atgtgcacga tgttggggag cttaacaccc gacttacaga tgatgtctcc 540 aagattaatg aaggaattgg tgacaaaatt ggaatgttct ttcagtcaat ggcaacattt 600 ttcactgggt ttatagtagg atttacacgt ggttggaagc taacccttgt gattttggcc 660 atcagtcctg ttcttggact gtcagctgct gtctgggcaa agatactatc ttcatttact 720 gataaagaac tcttagcgta tgcaaaagct ggagcagtag ctgaagaggt cttggcagca 780 attagaactg tgattgcatt tggaggacaa aagaaagaac ttgaaaggta caacaaaaat 840 ttagaagaag ctaaaagaat tgggataaag aaagctatta cagccaatat ttctataggt 900 gctgctttcc tgctgatcta tgcatcttat gctctggcct tctggtatgg gaccaccttg 960 gtcctctcag gggaatattc tattggacaa gtactcactg tattttctgt attaattggg 1020 gcttttagtg ttggacaggc atctccaagc attgaagcat ttgcaaatgc aagaggagca 1080 gcttatgaaa tcttcaagat aattgataat aagccaagta ttgacagcta ttcgaagagt 1140 gggcacaaac cagataatat taagggaaat ttggaattca gaaatgttca cttcagttac 1200 ccatctcgaa aagaagttaa gatcttgaag ggtctgaacc tgaaggtgca gagtgggcag 1260 acggtggccc tggttggaaa cagtggctgt gggaagagca caacagtcca gctgatgcag 1320 aggctctatg accccacaga ggggatggtc agtgttgatg gacaggatat taggaccata 1380 aatgtaaggt ttctacggga aatcattggt gtggtgagtc aggaacctgt attgtttgcc 1440 accacgatag ctgaaaacat tcgctatggc cgtgaaaatg tcaccatgga tgagattgag 1500 aaagctgtca aggaagccaa tgcctatgac tttatcatga aactgcctca taaatttgac 1560 accctggttg gagagagagg ggcccagttg agtggtgggc agaagcagag gatcgccatt 1620 gcacgtgccc tggttcgcaa ccccaagatc ctcctgctgg atgaggccac gtcagccttg 1680 gacacagaaa gcgaagcagt ggttcaggtg gctctggata aggccagaaa aggtcggacc 1740 accattgtga tagctcatcg tttgtctaca gttcgtaatg ctgacgtcat cgctggtttc 1800 gatgatggag tcattgtgga gaaaggaaat catgatgaac tcatgaaaga gaaaggcatt 1860 tacttcaaac ttgtcacaat gcagacagca ggaaatgaag ttgaattaga aaatgcagct 1920 gatgaatcca aaagtgaaat tgatgccttg gaaatgtctt caaatgattc aagatccagt 1980 ctaataagaa aaagatcaac tcgtaggagt gtccgtggat cacaagccca agacagaaag 2040 cttagtacca aagaggctct ggatgaaagt atacctccag tttccttttg gaggattatg 2100 aagctaaatt taactgaatg gccttatttt gttgttggtg tattttgtgc cattataaat 2160 ggaggcctgc aaccagcatt tgcaataata ttttcaaaga ttataggggt ttttacaaga 2220 attgatgatc ctgaaacaaa acgacagaat agtaacttgt tttcactatt gtttctagcc 2280 cttggaatta tttcttttat tacatttttc cttcagggtt tcacatttgg caaagctgga 2340 gagatcctca ccaagcggct ccgatacatg gttttccgat ccatgctcag acaggatgtg 2400 agttggtttg atgaccctaa aaacaccact ggagcattga ctaccaggct cgccaatgat 2460 gctgctcaag ttaaaggggc tataggttcc aggcttgctg taattaccca gaatatagca 2520 aatcttggga caggaataat tatatccttc atctatggtt ggcaactaac actgttactc 2580 ttagcaattg tacccatcat tgcaatagca ggagttgttg aaatgaaaat gttgtctgga 2640 caagcactga aagataagaa agaactagaa ggtgctggga agatcgctac tgaagcaata 2700 gaaaacttcc gaaccgttgt ttctttgact caggagcaga agtttgaaca tatgtatgct 2760 cagagtttgc aggtaccata cagaaactct ttgaggaaag cacacatctt tggaattaca 2820 ttttccttca cccaggcaat gatgtatttt tcctatgctg gatgtttccg gtttggagcc 2880 tacttggtgg cacataaact catgagcttt gaggatgttc tgttagtatt ttcagctgtt 2940 gtctttggtg ccatggccgt ggggcaagtc agttcatttg ctcctgacta tgccaaagcc 3000 aaaatatcag cagcccacat catcatgatc attgaaaaaa cccctttgat tgacagctac 3060 agcacggaag gcctaatgcc gaacacattg gaaggaaatg tcacatttgg tgaagttgta 3120 ttcaactatc ccacccgacc ggacatccca gtgcttcagg gactgagcct ggaggtgaag 3180 aagggccaga cgctggctct ggtgggcagc agtggctgtg ggaagagcac agtggtccag 3240 ctcctggagc ggttctacga ccccttggca gggaaagtgc tgcttgatgg caaagaaata 3300 aagcgactga atgttcagtg gctccgagca cacctgggca tcgtgtccca ggagcccatc 3360 ctgtttgact gcagcattgc tgagaacatt gcctatggag acaacagccg ggtggtgtca 3420 caggaagaga ttgtgagggc agcaaaggag gccaacatac atgccttcat cgagtcactg 3480 cctaataaat atagcactaa agtaggagac aaaggaactc agctctctgg tggccagaaa 3540 caacgcattg ccatagctcg tgcccttgtt agacagcctc atattttgct tttggatgaa 3600 gccacgtcag ctctggatac agaaagtgaa aaggttgtcc aagaagccct ggacaaagcc 3660 agagaaggcc gcacctgcat tgtgattgct caccgcctgt ccaccatcca gaatgcagac 3720 ttaatagtgg tgtttcagaa tggcagagtc aaggagcatg gcacgcatca gcagctgctg 3780 gcacagaaag gcatctattt ttcaatggtc agtgtccagg ctggaacaaa gcgccagtga 3840 31 1318 DNA Homo sapiens UPAR (urokinase-type plasminogen activator receptor) XM009232 31 atgggtcacc cgccgctgct gccgctgctg ctgctgctcc acacctgcgt cccagcctct 60 tggggcctgc ggtgcatgca gtgtaagacc aacggggatt gccgtgtgga agagtgcgcc 120 ctgggacagg acctctgcag gaccacgatc gtgcgcttgt gggaagaagg agaagagctg 180 gagctggtgg agaaaagctg tacccactca gagaagacca acaggaccct gagctatcgg 240 actggcttga agatcaccag ccttaccgag gttgtgtgtg ggttagactt gtgcaaccag 300 ggcaactctg gccgggctgt cacctattcc cgaagccgtt acctcgaatg catttcctgt 360 ggctcatcag acatgagctg tgagaggggc cggcaccaga gcctgcagtg ccgcagccct 420 gaagaacagt gcctggatgt ggtgacccac tggatccagg aaggtgaaga agggcgtcca 480 aaggatgacc gccacctccg tggctgtggc taccttcccg gctgcccggg ctccaatggt 540 ttccacaaca acgacacctt ccacttcctg aaatgctgca acaccaccaa atgcaacgag 600 ggcccaatcc tggagcttga aaatctgccg cagaatggcc gccagtgtta cagctgcaag 660 gggaacagca cccatggatg ctcctctgaa gagactttcc tcattgactg ccgaggcccc 720 atgaatcaat gtctggtagc caccggcact cacgaaccga aaaaccaaag ctatatggta 780 agaggctgtg caaccgcctc aatgtgccaa catgcccacc tgggtgacgc cttcagcatg 840 aaccacattg atgtctcctg ctgtactaaa agtggctgta accacccaga cctggatgtc 900 cagtaccgca gtggggctgc tcctcagcct ggccctgccc atctcagcct caccatcacc 960 ctgctaatga ctgccagact gtggggaggc actctcctct ggacctaaac ctgaaatccc 1020 cctctctgcc ctggctggat ccgggggacc cctttgccct tccctcggct cccagcccta 1080 cagacttgct gtgtgacctc aggccagtgt gccgacctct ctgggcctca gttttcccag 1140 ctatgaaaac agctatctca caaagttgtg tgaagcagaa gagaaaagct ggaggaaggc 1200 cgtgggccaa tgggagagct cttgttatta ttaatattgt tgccgctgtt gtgttgttgt 1260 tattaattaa tattcatatt atttatttta tacttacata aagattttgt accagtgg 1318 32 636 DNA Homo sapiens Bak U16811 32 atggcttcgg ggcaaggccc aggtcctcccc aggcaggagt gcggagagcc tgccctgccc 60 tctgcttctg aggagcaggt agcccaggac acagaggagg ttttccgcag ctacgttttt 120 taccgccatc agcaggaaca ggaggctgaa ggggtggctg cccctgccga cccagagatg 180 gteaccttac ctctgcaacc tagcagcacc atggggcagg tgggacggca gc'tcgcca'tc 240 atcggggacg acatcaaccg acgctatgac tcagagttcc agaccatgtt gcagcacctg 300 cagcccacgg cagagaatgc ctatgagtac ttcaccaaga ttgccaccag cctgtttgag 360 agtggcatca attggggccg tgtggtggct cttctgggct tcggctaccg tctggcccta 420 cacgtctacc agcatggcct gactggcttc ctaggccagg tgacccgctt cgtggtcgac 480 ttcatgctgc atcactgcat tgcccggtgg attgcacaga ggggtggctg ggtggcagcc 540 ctgaacttgg gcaatggtcc catcctgaac gtgctggtgg ttctgggtgt ggttctgttg 600 ggccagtttg tggtacgaag attcttcaaa tcatga 636 33 579 DNA Homo sapiens Bax al [pha L22473 33 atggacgggt ccggggagca gcccagaggc ggggggccca ccagctctga gcagatcatg 60 aagacagggg cccttttgct tcagggtttc atccaggatc gagcagggcg aatggggggg 120 gaggcacccg agctggccct ggacccggtg cctcaggatg cgtccaccaa gaagctgagc 180 432 DNA Homo sapiens Bax delta U19599 35 atggacgggt ccggggagca gcccagaggc ggggggecca ccagctctga gcagatcatg 60 aagacagggg cccttttgct tcaggggatg attgccgccg tggacacaga ctccccccga 120 gaggtctttt tccgagtggc agctgacatg ttttctgacg gcaacttcaa ctggggccgg 180 gttgtcgccc ttttctactt tgccagcaaa ctggtgctca aggccctgtg caccaaggtg 240 ccggaactga tcagaaccat catgggctgg acattggact tcctccggga gcggctgttg 300 ggctggatcc aagaccaggg tggttgggac ggcctcctct cctactttgg gacgcccacg 360 tggcagaccg tgaccatctt tgtggcggga gtgctcaccg cctcgctcac catctggaag 420 aagatgggct ga 432 36 495 DNA Home > sapiens Bax epsolin AF007826 36 atggacgggt ceggggagea gcccagaggc ggggggecca ccagctctga gcagatcatg 60 aagacagggg cccttttgct tcagggtttc atccaggatc gagcagggcg aatggggggg 120 gaggcacccg agctggccct ggacccggtg cctcaggatg cgtccaccaa gaagctgagc 180 gagtgtctca agegcategg ggacgaactg gacagtaaca tggagctgea gaggatgatt 240 gccgccgtgg acacagactc cccccgagag gtctttttcc gagtggcagc tgacatgttt 300 tctgacggca acttcaactg gggccgggtt gtcgcccttt tctactttgc cagcaaactg 360 gtgctcaagg ctggcgtgaa atggcgtgat ctgggctcac tgcaacctct gcctcctggg 420 ttcaagcgat tcacctgcct cagcatccca aggagctggg attacaggcc ctgtgcacca 480 aggtgccgga actga 495 37 582 DNA Homo sapiens bcl-w U59747 37 atggcgaccc aagctgaggc ccgctgcacc ttctctgatc caggtctccg gtctttgggg caagtgcagg agtgggggct cgtctgcggg ggggccctgg cagcctcggc agaagggtta aagccatgcg tggcggctca acgaactttt ctgcactgtg agtggatggt gggcggagtt aggggaactg taactgtagg cccagacaca tgtctgtgga ggcagctgga gctgcatgtg tcaagggggc tgctgagagt ggcctacctg cacagctcta ggcatcagtg ggcctttttt cgggctctgg gctggccccg gatgagttcg accccaggct cccaactggg gtcaacaagg gagacgcggc tacggggacg aggacagtgc gctagcaagt tggcagactt gggagggccc agacccgctt cagcccagca gccgccttgt agatggaacc tggctgactg gggccctgga tgacgggggc ga tgtaggttat 60 agcagctgac 120 ccggcgcacc 180 acgcttcacc 240 agccttcttt 300 actggtggga 360 gatccacagc 420 ggaggcgcgg 480 cgtggcactg 540 582 38 2481 DNA Homo sapiens HIF-alpha U22431 38 atggagggcg ccggcggcgc gaacgacaag aagtctcgag atgcagccag atctcggcga gctcatcagt tgccacttcc acataatgtg aggcttacca tcagctattt gcgtgtgagg gaagatgaca tgaaagcaca gatgaattgc atggttctca cagatgatgg tgacatgatt ggattaactc agtttgaact aactggacac catgaggaaa tgagagaaat gcttacacac caaaacacac agcgaagctt ttttctcaga actatgaaca taaagtctgc aacatggaag tatgatacca acagtaacca acctcagtgt gtgctgattt gtgaacccat tcctcaccca actttcctca gtcgacacag cctggatatg gaattgatgg gatatgagcc agaagaactt gctttggact ctgatcatct gaccaaaact accacaggac agtacaggat gcttgccaaa gcaactgtca tatataacac caagaattct gttgtgagtg gtattattca gcacgacttg cttaaaccgg ttgaatcttc agatatgaaa gaagatacaa gtagcctctt tgacaaactt gccccagccg ctggagacac aatcatatct gatgaccagc aacttgagga agtaccatta gaaaaattac agaatataaa tttggcaatg ccacttcgaa gtagtgctga ccctgcactc aatccagagt cactggaact ttcttttacc aaaaagataa gttctgaacg tcgaaaagaa 60 agtaaagaat ctgaagtttt ttatgagctt 120 agttcgcatc ttgataaggc ctctgtgatg 180 aaacttctgg atgctggtga tttggatatt 240 ttttatttga aagccttgga tggttttgtt 300 tacatttctg ataatgtgaa caaatacatg 360 agtgtgtttg attttactca tccatgtgac 420 agaaatggcc ttgtgaaaaa gggtaaagaa 480 atgaagtgta ccctaactag ccgaggaaga 540 gtattgcact gcacaggcca cattcacgta 600 gggtataaga aaccacctat gacctgcttg 660 tcaaatattg aaattccttt agatagcaag 720 aaattttctt attgtgatga aagaattacc 780 ttaggccgct caatttatga atattatcat 840 catcatgata tgtttactaa aggacaagtc 900 agaggtggat atgtctgggt tgaaactcaa 960 caaccacagt gcattgtatg tgtgaattac 1020 attttctccc ttcaacaaac agaatgtgtc 1080 atgactcagc tattcaccaa agttgaatca 1140 aagaaggaac ctgatgcttt aactttgctg 1200 ttagattttg gcagcaacga cacagaaact 1260 tataatgatg taatgctccc ctcacccaac 1320 tctccattac ccaccgctga aacgccaaag 1380 aatcaagaag ttgcattaaa attagaacca 1440 atgccccaga ttcaggatca gacacctagt 1500 ccttccgatg gaagcactag acaaagttca cctgagccta atagtcccag tgaatattgt 1560 ttttatgtgg atagtgatat ggtcaatgaa ttcaagttgg aattggtaga aaaacttttt 1620 gctgaagaca cagaagcaaa gaacccattt tctactcagg acacagattt agacttggag 1680 atgttagctc cctatatccc aatggatgat gacttccagt tacgttcctt cgatcagttg 1740 tcaccattag aaagcagttc cgcaagccct gaaagcgcaa gtcctcaaag cacagttaca 1800 gtattccagc agactcaaat acaagaacct actgctaatg ccaccactac cactgccacc 1860 actgatgaat taaaaacagt gacaaaagac cgtatggaag acattaaaat attgattgca 1920 tctccatctc ctacccacat acataaagaa actactagtg ccacatcatc accatataga 1980 gatactcaaa gtcggacagc ctcaccaaac agagcaggaa aaggagtcat agaacagaca 2040 gaaaaatctc atccaagaag ccctaacgtg ttatctgtcg ctttgagtca aagaactaca 2100 gttcctgagg aagaactaaa tccaaagata ctagctttgc agaatgctca gagaaagcga 2160 aaaatggaac atgatggttc actttttcaa gcagtaggaa ttggaacatt attacagcag 2220 ccagacgatc atgcagctac tacatcactt tcttggaaac gtgtaaaagg atgcaaatct 2280 agtgaacaga atggaatgga gcaaaagaca attattttaa taccctctga tttagcatgt 2340 agactgctgg ggcaatcaat ggatgaaagt ggattaccac agctgaccag ttatgattgt 2400 gaagttaatg ctcctataca aggcagcaga aacctactgc agggtgaaga attactcaga 2460 gctttggatc aagttaactg a 2481 39 481 DNA Homo sapiens ID1 X77956 39 atgaaagtcg ccagtggcag caccgccacc gccgccgcgg gccccagctg cgcgctgaag 60 gccggcaaga cagcgagcgg tgcgggcgag gtggtgcgct gtctgtctga gcagagcgtg 120 gccatctcgc gctgccgggg cgccggggcg cgcctgcctg ccctgctgga cgagcagcag 180 gtaaacgtgc tgctctacga catgaacggc tgttactcac gcctcaagga gctggtgccc 240 accctgcccc agaaccgcaa ggtgagcaag gtggagattc tccagcacgt catcgactac 300 atcagggacc ttcagttgga gctgaactcg gaatccgaag ttgggacccc cgggggccga 360 gggctgccgg tccgggctcc gctcagcacc ctcaacggcg agatcagcgc cctgacggcc 420 gaggcggcat gcgttcctgc ggacgatcgc atcttgtgtc gctgaatggt gaaaaaaaaa 480 a 481 40 110 DNA Homo sapiens ID2B M96843 40 tgaaagcctt cagtcccgtg aggtccatta ggaaaaacag cctgttggac caccgcctgg 60 gcatctccca gagcaaaacc ccggtggatg acctgatgag cctgctgtaa 110 41 486 DNA Homo sapiens ID4 Y07958 41 atgaaggcgg tgagcccggt gcgcccctcg ggccgcaagg cgccgtcggg ctgcggcggc 60 ggggagctgg cgctgcgctg cctggccgag gcggcggcgg cggcggcggc agcgcgctgt gcgctgtgcc tgcagtgcga tatgaacgac accatcccgc ccaacaagaa agtcagcaaa atcctggacc tgcagctggc gctggagacg cccgcgccgc cacaccaccc ggccgggacc actgcgctca acaccgaccc ggccggcgcg cgctga cacggccaca gcctgggtgg ctccgcagcc 120 aaggcggccg aggcggcggc cgacgagccg 180 tgctatagcc gcctgcggag gctggtgccc 240 gtggagatcc tgcagcacgt tatcgactac 300 cacccggccc tgctgaggca gccaccaccg 360 tgtccagccg cgccgccgcg gaccccgctc 420 gtgaacaagc agggcgacag cattctgtgc 480 486 42 462 DNA Homo sapiens IGF1 NM000618 42 atgggaaaaa tcagcagtct tccaacccaa aaggtgaaga tgcacaccat gtcctcctcg accttcacca gctctgccac ggctggaccg gctcttcagt tcgtgtgtgg agacaggggc tccagcagtc ggagggcgcc tcagacaggc gatctaagga ggctggagat gtattgcgca gtccgtgccc agcgccacac cgacatgccc gcaagtagag ggagtgcagg aaacaagaac ttatttaagt gctgcttttg tgatttcttg 60 catctcttct acctggcgct gtgcctgctc 120 gagacgctct gcggggctga gctggtggat 180 ttttatttca acaagcccac agggtatggc 240 atcgtggatg agtgctgctt ccggagctgt 300 cccctcaagc ctgccaagtc agctcgctct 360 aagacccaga aggaagtaca tttgaagaac 420 tacaggatgt ag 462 43 591 DNA Homo sapiens PDGFA NM002607 43 atgaggacct tggcttgcct gctgctcctc ggctgcggat acctcgccca tgttctggcc 60 gaggaagccg agatcccccg cgaggtgatc gagaggctgg cccgcagtca gatccacagc 120 atccgggacc tccagcgact cctggagata gactccgtag ggagtgagga ttctttggac 180 accagcctga gagctcacgg ggtccacgcc actaagcatg tgcccgagaa gcggcccctg 240 cccattcgga ggaagagaag catcgaggaa gctgtccccg ctgtctgcaa gaccaggacg 300 gtcatttacg agattcctcg gagtcaggtc gaccccacgt ccgccaactt cctgatctgg 360 cccccgtgcg tggaggtgaa acgctgcacc ggctgctgca acacgagcag tgtcaagtgc 420 cagccctccc gcgtccacca ccgcagcgtc aaggtggcca aggtggaata cgtcaggaag 480 aagccaaaat taaaagaagt ccaggtgagg ttagaggagc atttggagtg cgcctgcgcg 540 accacaagcc tgaatccgga ttatcgggaa gaggacacgg atgtgaggtg a 591 44 528 DNA Homo sapiens PDGFRA XM003568 44 atggccaagc ctgaccacgc taccagtgaa gtctacgaga tcatggtgaa atgctggaac 60 agtgagccgg agaagagacc ctccttttac cacctgagtg agattgtgga gaatctgctg 120 cctggacaat ataaaaagag ttatgaaaaa attcacctgg acttcctgaa gagtgaccat 180 cctgctgtgg cacgcatgcg tgtggactca aacgaggaag acaagctgaa ggactgggag gacagtggct acatcattcc tctgcctgac ggcaagagga acagacacag ctcgcagacc agcagttcca ccttcatcaa gagagaggac gacatcggca tagactcttc agacctggtg 45 1911 DNA Homo sapiens PDGFRB XM003790 gacaatgcat acattggtgt cacctacaaa 240 ggtggtctgg atgagcagag actgagcgct 300 attgaccctg tccctgagga ggaggacctg 360 tctgaagaga gtgccattga gacgggttcc 420 gagaccattg aagacatcga catgatggat 480 gaagacagct tcctgtaa 528 45 atgcggcttc cgggtgcgat gccagctctg ctcctgttac ttctggaacc acagatctct gagcttgtcc tcaatgtctc cagcaccttc gtgtgggaac ggatgtccca ggagccccca ttctccagcg tgctcacact gaccaacctc acccacaatg actcccgtgg actggagacc ccagatccca ccgtgggctt cctccctaat gaaataactg agatcaccat tccatgccga cacgagaaga aaggggacgt tgcactgcct ggtatctttg aggacagaag ctacatctgc tctgatgcct actatgtcta cagactccag gtgcagactg tggtccgcca gggtgagaac gaggtggtca acttcgagtg gacatacccc gtgactgact tcctcttgga tatgccttac gccctcaaag gcgagctgct gttgctgtct 60 cagggcctgg tcgtcacacc cccggggcca 120 gttctgacct gctcgggttc agctccggtg 180 caggaaatgg ccaaggccca ggatggcacc 240 actgggctag acacgggaga atacttttgc 300 gatgagcgga aacggctcta catctttgtg 360 gatgccgagg aactattcat ctttctcacg 420 gtaacagacc cacagctggt ggtgacaetg 480 gtcccctatg atcaccaacg tggcttttct 540 aaaaccacca ttggggacag ggaggtggat 600 gtgtcatcca tcaacgtctc tgtgaacgca 660 atcaccctca tgtgcattgt gatcgggaat 720 cgcaaagaaa gtgggcggct ggtggagccg 780 cacatccgct ccatcctgca catccccagt 840 gccgagttag aagactcggg gacctacacc tgcaatgtga cggagagtgt gaatgaccat 900 caggatgaaa aggccatcaa catcaccgtg gttgagagcg gctacgtgcg gctcctggga 960 gaggtgggca cactacaatt tgctgagctg catcggagcc ggacactgca ggtagtgttc 1020 gaggcctacc caccgcccac tgtcctgtgg ttcaaagaca accgcaccct gggcgactcc 1080 agcgctggcg aaatcgccct gtccacgcgc aacgtgtcgg agacccggta tgtgtcagag 1140 ctgacactgg ttcgcgtgaa ggtggcagag gctggccact acaccatgcg ggccttccat 1200 gaggatgctg aggtccagct ctccttccag ctacagatca atgtccctgt ccgagtgctg 1260 gagctaagtg agagccaccc tgacagtggg gaacagacag tccgctgtcg tggccggggc 1320 atgccccagc cgaacatcat ctggtctgcc tgcagagacc tcaaaaggtg tccacgtgag 1380 ctgccgccca cgctgctggg gaacagttcc gaagaggaga gccagctgga gactaacgtg 1440 acgtactggg aggaggagca ggagtttgag gtggtgagca cactgcgtct gcagcacgtg 1500 gatcggccac tgtcggtgcg ctgcacgctg cgcaacgctg tgggccagga cacgcaggag 1560 gtcatcgtgg tgccacactc cttgcccttt aaggtggtgg tgatctcagc catcctggcc 1620 ctggtggtgc tcaccatcat ctcccttatc atcctcatca tgctttggca gaagaagcca 1680 cgttacgaga tccgatggaa ggtgattgag tctgtgagct ctgacggcca tgagtacatc 1740 tacgtggacc ccatgcagct gccctatgac tccacgtggg agctgccgcg ggaccagctt 1800 gtgctgggac gcaccctcgg ctctggggcc tttgggcagg tggtggaggc cacggttcat 1860 ggcctgagcc attttcaagc cccaatgaaa gtggccgtca aaaatgctta a 1911 46 1176 DNA Homo sapiens TGFbetal NM000660 46 atgccgccct ccgggctgcg gctgctgccg ctgctgctac cgctgctgtg gctactggtg 60 ctgacgcctg gcccgccggc cgcgggacta tccacctgca agactatcga catggagctg 120 gtgaagcgga agcgcatcga ggccatccgc ggccagatcc tgtccaagct gcggctcgcc 180 agccccccga gccaggggga ggtgccgccc ggcccgctgc ccgaggccgt gctcgccctg 240 tacaacagca cccgcgaccg ggtggccggg gagagtgcag aaccggagcc cgagcctgag 300 gccgactact acgccaagga ggtcacccgc gtgctaatgg tggaaaccca caacgaaatc 360 tatgacaagt tcaagcagag tacacacagc atatatatgt tcttcaacac atcagagctc 420 cgagaagcgg tacctgaacc cgtgttgctc tcccgggcag agctgcgtct gctgaggagg 480 ctcaagttaa aagtggagca gcacgtggag ctgtaccaga aatacagcaa caattcctgg 540 cgatacctca gcaaccggct gctggcaccc agcgactcgc cagagtggtt atcttttgat 600 gtcaccggag ttgtgcggca gtggttgagc cgtggagggg aaattgaggg ctttcgcctt 660 agcgcccact gctcctgtga cagcagggat aacacactgc aagtggacat caacgggttc 720 actaccggcc gccgaggtga cctggccacc attcatggca tgaaccggcc tttcctgctt 780 ctcatggcca ccccgctgga gagggcccag catctgcaaa gctcccggca ccgccgagcc 840 ctggacacca actattgctt cagctccacg gagaagaact gctgcgtgcg gcagctgtac 900 attgacttcc gcaaggacct cggctggaag tggatccacg agcccaaggg ctaccatgcc 960 aacttctgcc tcgggccctg cccctacatt tggagcctgg acacgcagta cagcaaggtc 1020 ctggccctgt acaaccagca taacccgggc gcctcggcgg cgccgtgctg cgtgccgcag 1080 gcgctggagc cgctgcccat cgtgtactac gtgggccgca agcccaaggt ggagcagctg 1140 tccaacatga tcgtgcgctc ctgcaagtgc agctga 1176 47 1245 DNA Homo sapiens TGFbeta2 NM003238 47 atgcactact gtgtgctgag cgcttttctg atcctgcatc tggtcacggt cgcgctcagc 60 ctgtctacct gcagcacact cgatatggac cagttcatgc gcaagaggat cgaggcgatc 120 cgcgggcaga tcctgagcaa gctgaagctc accagtcccc cagaagacta tcctgagccc 180 gaggaagtcc ccccggaggt gatttccatc tacaacagca ccagggactt gctccaggag 240 aaggcgagcc ggagggcggc cgcctgcgag cgcgagagga gcgacgaaga gtactacgcc 300 aaggaggttt acaaaataga catgccgccc ttcttcccct ccgaaaatgc catcccgccc 360 actttctaca gaccctactt cagaattgtt cgatttgacg tctcagcaat ggagaagaat 420 gcttccaatt tggtgaaagc agagttcaga gtctttcgtt tgcagaaccc aaaagccaga 480 gtgcctgaac aacggattga gctatatcag attctcaagt ccaaagattt aacatctcca 540 acccagcgct acatcgacag caaagttgtg aaaacaagag cagaaggcga atggctctcc 600 ttcgatgtaa ctgatgctgt tcatgaatgg cttcaccata aagacaggaa cctgggattt 660 aaaataagct tacactgtcc ctgctgcact tttgtaccat ctaataatta catcatccca 720 aataaaagtg aagaactaga agcaagattt gcaggtattg atggcacctc cacatatacc 780 agtggtgatc agaaaactat aaagtccact aggaaaaaaa acagtgggaa gaccccacat 840 ctcctgctaa tgttattgcc ctcctacaga cttgagtcac aacagaccaa ccggcggaag 900 aagcgtgctt tggatgcggc ctattgcttt agaaatgtgc aggataattg ctgcctacgt 960 ccactttaca ttgatttcaa gagggatcta gggtggaaat ggatacacga acccaaaggg 1020 tacaatgcca acttctgtgc tggagcatgc ccgtatttat ggagttcaga cactcagcac 1080 agcagggtcc tgagcttata taataccata aatccagaag catctgcttc tccttgctgc 1140 gtgtcccaag atttagaacc tctaaccatt ctctactaca ttggcaaaac acccaagatt 1200 gaacagcttt ctaatatgat tgtaaagtct tgcaaatgca gctaa 1245 48 1239 DNA Homo sapiens TGFbeta3 XM007417 48 atgaagatgc acttgcaaag ggctctggtg gtcctggccc tgctgaactt tgccacggtc 60 agcctctctc tgtccacttg caccaccttg gacttcggcc acatcaagaa gaagagggtg 120 gaagccatta ggggacagat cttgagcaag ctcaggctca ccagcccccc tgagccaacg 180 gtgatgaccc acgtccccta tcaggtcctg gccctttaca acagcacccg ggagctgctg 240 gaggagatgc atggggagag ggaggaaggc tgcacccagg aaaacaccga gtcggaatac 300 tatgccaaag aaatccataa attcgacatg atccaggggc tggcggagca caacgaactg 360 gctgtctgcc ctaaaggaat tacctccaag gttttccgct tcaatgtgtc ctcagtggag 420 aaaaatagaa ccaacctatt ccgagcagaa ttccgggtct tgcgggtgcc caaccccagc 480 tctaagcgga atgagcagag gatcgagctc ttccagatcc ttcggccaga tgagcacatt 540 gccaaacagc gctatatcgg tggcaagaat ctgcccacac ggggcactgc cgagtggctg 600 tcctttgatg tcactgacac tgtgcgtgag tggctgttga gaagagagtc caacttaggt 660 ctagaaatca gcattcactg tccatgtcac acctttcagc ccaatggaga tatcctggaa 720 aacattcacg aggtgatgga aatcaaattc aaaggcgtgg acaatgagga tgaccatggc 780 cgtggagatc tggggcgcct caagaagcag aaggatcacc acaaccctca tctaatcctc 840 atgatgattc ccccacaccg gctcgacaac ccgggccagg ggggtcagag gaagaagcgg 900 gctttggaca ccaattactg cttccgcaac ttggaggaga actgctgtgt gcgccccctc 960 tacattgact tccgacagga tctgggctgg aagtgggtcc atgaacctaa gggctactat 1020 gccaacttct gctcaggccc ttgcccatac ctccgcagtg cagacacaac ccacagcacg 1080 gtgctgggac tgtacaacac tctgaaccct gaagcatctg cctcgccttg ctgcgtgccc 1140 caggacctgg agcccctgac catcctgtac tatgttggga ggacccccaa agtggagcag 1200 ctctccaaca tggtggtgaa gtcttgtaaa tgtagctga 1239 49 1704 DNA Homo sapiens TGFbetaR2 XM003094 49 atgggtcggg ggctgctcag gggcctgtgg ccgctgcaca tcgtcctgtg gacgcgtatc 60 gccagcacga tcccaccgca cgttcagaag tcggttaata acgacatgat agtcactgac 120 aacaacggtg cagtcaagtt tccacaactg tgtaaatttt gtgatgtgag attttccacc 180 tgtgacaacc agaaatcctg catgagcaac tgcagcatca cctccatctg tgagaagcca 240 caggaagtct gtgtggctgt atggagaaag aatgacgaga acataacact agagacagtt 300 tgccatgacc ccaagctccc ctaccatgac tttattctgg aagatgctgc ttctccaaag 360 tgcattatga aggaaaaaaa aaagcctggt gagactttct tcatgtgttc ctgtagctct 420 gatgagtgca atgacaacat catcttctca gaagaatata acaccagcaa tcctgacttg 480 ttgctagtca tatttcaagt gacaggcatc agcctcctgc caccactggg agttgccata 540 tctgtcatca tcatcttcta ctgctaccgc gttaaccggc agcagaagct gagttcaacc 600 tgggaaaccg gcaagacgcg gaagctcatg gagttcagcg agcactgtgc catcatcctg 660 gaagatgacc gctctgacat cagctccacg tgtgccaaca acatcaacca caacacagag 720 ctgctgccca ttgagctgga caccctggtg gggaaaggtc gctttgctga ggtctataag 780 gccaagctga agcagaacac ttcagagcag tttgagacag tggcagtcaa gatctttccc 840 tatgaggagt atgcctcttg gaagacagag aaggacatct tctcagacat caatctgaag 900 catgagaaca tactccagtt cctgacggct gaggagcgga agacggagtt ggggaaacaa 960 tactggctga tcaccgcctt ccacgccaag ggcaacctac aggagtacct gacgcggcat 1020 gtcatcagct gggaggacct gcgcaagctg ggcagctccc tcgcccgggg gattgctcac 1080 ctccacagtg atcacactcc atgtgggagg cccaagatgc ccatcgtgca cagggacctc 1140 aagagctcca atatcctcgt gaagaacgac ctaacctgct gcctgtgtga ctttgggctt 1200 tccctgcgtc tggaccctac tctgtctgtg gatgacctgg ctaacagtgg gcaggtggga 1260 actgcaagat acatggctcc agaagtccta gaatccagga tgaatttgga gaatgttgag 1320 tccttcaagc agaccgatgt ctactccatg gctctggtgc tctgggaaat gacatctcgc 1380 tgtaatgcag tgggagaagt aaaagattat gagcctccat ttggttccaa ggtgcgggag 1440 cacccctgtg tcgaaagcat gaaggacaac gtgttgagag atcgagggcg accagaaatt 1500 cccagcttct ggctcaacca ccagggcatc cagatggtgt gtgagacgtt gactgagtgc 1560 tgggaccacg acccagaggc ccgtctcaca gcccagtgtg tggcagaacg cttcagtgag 1620 ctggagcatc tggacaggct ctcggggagg agctgctcgg aggagaagat tcctgaagac 1680 ggctccctaa acactaccaa atag 1704 50 609 DNA Homo sapiens TGFbeta3 XM001924 50 atgtctcatt acaccattat tgagaatatt tgtcctaaag atgaatctgt gaaattctac 60 agtcccaaga gagtgcactt tcctatcccg caagctgaca tggataagaa gcgattcagc 120 tttgtcttca agcctgtctt caacacctca ctgctctttc tacagtgtga gctgacgctg 180 tgtacgaaga tggagaagca cccccagaag ttgcctaagt gtgtgcctcc tgacgaagcc 240 tgcacctcgc tggacgcctc gataatctgg gccatgatgc agaataagaa gacgttcact 300 aagccccttg ctgtgatcca ccatgaagca gaatctaaag aaaaaggtcc aagcatgaag 360 gaaccaaatc caatttctcc accaattttc catggtctgg acaccctaac cgtgatgggc 420 attgcgtttg cagcctttgt gatcggagca ctcctgacgg gggccttgtg gtacatctat 480 tctcacacag gggagacagc aggaaggcag caagtcccca cctccccgcc agcctcggaa 540 aacagcagtg ctgcccacag catcggcagc acgcagagca cgccttgctc cagcagcagc 600 acggcctag 609 51 3633 DNA Homo sapiens EGFR X00588 51 atgcgaccct ccgggacggc cggggcagcg ctcctggcgc tgctggctgc gctctgcccg 60 gcgagtcggg ctctggagga aaagaaagtt tgccaaggca cgagtaacaa gctcacgcag 120 ttgggcactt ttgaagatca ttttctcagc ctccagagga tgttcaataa ctgtgaggtg 180 gtccttggga atttggaaat tacctatgtg cagaggaatt atgatctttc cttcttaaag 240 accatccagg aggtggctgg ttatgtcctc attgccctca acacagtgga gcgaattcct 300 ttggaaaacc tgcagatcat cagaggaaat atgtactacg aaaattccta tgccttagca 360 gtcttatcta actatgatgc aaataaaacc ggactgaagg agctgcccat gagaaattta 420 caggaaatcc tgcatggcgc cgtgcggttc agcaacaacc ctgccctgtg caacgtggag 480 agcatccagt ggcgggacat agtcagcagt gactttctca gcaacatgtc gatggacttc 540 cagaaccacc tgggcagctg ccaaaagtgt gatccaagct gtcccaatgg gagctgctgg 600 ggtgcaggag aggagaactg ccagaaactg accaaaatca tctgtgccca gcagtgctcc 660 gggcgctgcc gtggcaagtc ccccagtgac tgctgccaca accagtgtgc tgcaggctgc 720 acaggccccc gggagagcga ctgcctggtc tgccgcaaat tccgagacga agccacgtgc 780 aaggacacct gccccccact catgctctac aaccccacca cgtaccagat ggatgtgaac 840 cccgagggca aatacagctt tggtgccacc tgcgtgaaga agtgtccccg taattatgtg 900 gtgacagatc acggctcgtg cgtccgagcc tgtggggccg acagctatga gatggaggaa 960 gacggcgtcc gcaagtgtaa gaagtgcgaa gggccttgcc gcaaagtgtg taacggaata 1020 ggtattggtg aatttaaaga ctcactctcc ataaatgcta cgaatattaa acacttcaaa 1080 aactgcacct ccatcagtgg cgatctccac atcctgccgg tggcatttag gggtgactcc 1140 ttcacacata ctcctcctct ggatccacag gaactggata ttctgaaaac cgtaaaggaa 1200 atcacagggt ttttgctgat tcaggcttgg cctgaaaaca ggacggacct ccatgccttt 1260 gagaacctag aaatcatacg cggcaggacc aagcaacatg gtcagttttc tcttgcagtc 1320 gtcagcctga acataacatc cttgggatta cgctccctca aggagataag tgatggagat 1380 gtgataattt caggaaacaa aaatttgtgc tatgcaaata caataaactg gaaaaaactg 1440 tttgggacct ccggtcagaa aaccaaaatt ataagcaaca gaggtgaaaa cagctgcaag 1500 gccacaggcc aggtctgcca tgccttgtgc tcccccgagg gctgctgggg cccggagccc 1560 agggactgcg tctcttgccg gaatgtcagc cgaggcaggg aatgcgtgga caagtgcaag 1620 cttctggagg gtgagccaag ggagtttgtg gagaactctg agtgcataca gtgccaccca 1680 gagtgcctgc ctcaggccat gaacatcacc tgcacaggac ggggaccaga caactgtatc 1740 cagtgtgccc actacattga cggcccccac . tgcgtcaaga cctgcccggc aggagtcatg 1800 ggagaaaaca acaccctggt ctggaagtac gcagacgccg gccatgtgtg ccacctgtgc 1860 catccaaact gcacctacgg atgcactggg ccaggtcttg aaggctgtcc aacgaatggg 1920 cctaagatcc cgtccatcgc cactgggatg gtgggggccc tcctcttgct gctggtggtg 1980 gCcctgggga tcggcctctt catgcgaagg cgccacatcg ttcggaagcg cacgctgcgg 2040 aggctgctgc aggagaggga gcttgtggag cctcttacac ccagtggaga agctcccaac 2100 caagctctct tgaggatctt gaaggaaact gaattcaaaa agatcaaagt gctgggctcc 2160 ggtgcgttcg gcacggtgta taagggactc tggatcccag aaggtgagaa agttaaaatt 2220 cccgtcgcta tcaaggaatt aagagaagca acatctccga aagccaacaa ggaaatcctc 2280 gatgaagcct acgtgatggc cagcgtggac aacccccacg tgtgccgcct gctgggcatc 2340 tgcctcacct ccaccgtgca actcatcacg cagctcatgc ccttcggctg cctcctggac 2400 tatgtccggg aacacaaaga caatattggc tcccagtacc tgctcaactg gtgtgtgcag 2460 atcgcaaagg gcatgaacta cttggaggac cgtcgcttgg tgcaccgcga cctggcagcc 2520 aggaacgtac tggtgaaaac accgcagcat gtcaagatca cagattttgg gctggccaaa 2580 ctgctgggtg cggaagagaa agaataccat gcagaaggag gcaaagtgcc tatcaagtgg 2640 atggcattgg aatcaatttt acacagaatc tatacccacc agagtgatgt ctggagctac 2700 ggggtgaccg tttgggagtt gatgaccttt ggatccaagc catatgacgg aatccctgcc 2760 agcgagatct cctccatcct ggagaaagga gaacgcctcc ctcagccacc catatgtacc 2820 atcgatgtct acatgatcat ggtcaagtgc tggatgatag acgcagatag tcgcccaaag 2880 ttccgtgagt tgatcatcga attctccaaa atggcccgag acccccagcg ctaccttgtc 2940 attcaggggg atgaaagaat gcatttgcca agtcctacag actccaactt ctaccgtgcc 3000 ctgatggatg aagaagacat ggacgacgtg gtggatgccg acgagtacct catcccacag 3060 cagggcttct tcagcagccc ctccacgtca cggactcccc tcctgagctc tctgagtgca 3120 accagcaaca attccaccgt ggcttgcatt gatagaaatg ggctgcaaag ctgtcccatc 3180 aaggaagaca gcttcttgca gcgatacagc tcagacccca caggcgcctt gactgaggac 3240 agcatagacg acaccttcct cccagtgcct gaatacataa accagtccgt tcccaaaagg 3300 cccgctggct ctgtgcagaa tcctgtctat cacaatcagc ctctgaaccc cgcgcccagc 3360 agagacccac actaccagga cccccacagc actgcagtgg gcaaccccga gtatctcaac 3420 actgtccagc ccacctgtgt caacagcaca ttcgacagcc ctgcccactg ggcccagaaa 3480 ggcagccacc aaattagcct ggacaaccct gactaccagc aggacttctt tcccaaggaa 3540 gccaagccaa atggcatctt taagggctcc acagctgaaa atgcagaata cctaagggtc 3600 gcgccacaaa gcagtgaatt tattggagca tga 3633 52 3768 DNA Homo sapiens ERBB2 NM004448 52 atggagctgg cggccttgtg ccgctggggg ctcctcctcg ccctcttgcc ccccggagcc 60 gcgagcaccc aagtgtgcac cggcacagac atgaagctgc ggctccctgc cagtcccgag 120 acccacctgg acatgctccg ccacctctac cagggctgcc aggtggtgca gggaaacctg 180 gaactcacct acctgcccac caatgccagc ctgtccttcc tgcaggatat ccaggaggtg 240 cagggctacg tgctcatcgc tcacaaccaa gtgaggcagg tcccactgca gaggctgcgg 300 attgtgcgag gcacccagct ctttgaggac aactatgccc tggccgtgct agacaatgga 360 gacccgctga acaataccac ccctgtcaca ggggcctccc caggaggcct gcgggagctg 420 cagcttcgaa gcctcacaga gatcttgaaa ggaggggtct tgatccagcg gaacccccag 480 ctctgctacc aggacacgat tttgtggaag gacatcttcc acaagaacaa ccagctggct 540 ctcacactga tagacaccaa ccgctctcgg gcctgccacc cctgttctcc gatgtgtaag 600 ggctcccgct gctggggaga gagttctgag gattgtcaga gcctgacgcg cactgtctgt 660 gccggtggct gtgcccgctg caaggggcca ctgcccactg actgctgcca tgagcagtgt 720 gctgccggct gcacgggccc caagcactct gactgcctgg cctgcctcca cttcaaccac 780 agtggcatct gtgagctgca ctgcccagcc ctggtcacct acaacacaga cacgtttgag 840 tccatgccca atcccgaggg ccggtataca ttcggcgcca gctgtgtgac tgcctgtccc 900 tacaactacc tttctacgga cgtgggatcc tgcaccctcg tctgccccct gcacaaccaa 960 gaggtgacag cagaggatgg aacacagcgg tgtgagaagt gcagcaagcc ctgtgcccga 1020 gtgtgctatg gtctgggcat ggagcacttg cgagaggtga gggcagttac cagtgccaat 1080 atccaggagt ttgctggctg caagaagatc tttgggagcc tggcatttct gccggagagc 1140 tttgatgggg acccagcctc caacactgcc ccgctccagc cagagcagct ccaagtgttt 1200 gagactctgg aagagatcac aggttaccta tacatctcag catggccgga cagcctgcct 1260 gacctcagcg tcttccagaa cctgcaagta atccggggac gaattctgca caatggcgcc 1320 tactcgctga ccctgcaagg gctgggcatc agctggctgg ggctgcgctc actgagggaa 1380 ctgggcagtg gactggccct catccaccat aacacccacc tctgcttcgt gcacacggtg 1440 ccctgggacc agctctttcg gaacccgcac caagctctgc tccacactgc caaccggcca 1500 gaggacgagt gtgtgggcga gggcctggcc tgccaccagc tgtgcgcccg agggcactgc 1560 tggggtccag ggcccaccca gtgtgtcaac tgcagccagt tccttcgggg ccaggagtgc 1620 gtggaggaat gccgagtact gcaggggctc cccagggagt atgtgaatgc caggcactgt 1680 ttgccgtgcc accctgagtg tcagccccag aatggctcag tgacctgttt tggaccggag 1740 gctgaccagt gtgtggcctg tgcccactat aaggaccctc ccttctgcgt ggcccgctgc 1800 cccagcggtg tgaaacctga cctctcctac atgcccatct ggaagtttcc agatgaggag 1860 ggcgcatgcc agccttgccc catcaactgc acccactcct gtgtggacct ggatgacaag 1920 ggctgccccg ccgagcagag agccagccct ctgacgtcca tcgtctctgc ggtggttggc 1980 attctgctgg tcgtggtctt gggggtggtc tttgggatcc tcatcaagcg acggcagcag 2040 aagatccgga agtacacgat gcggagactg ctgcaggaaa cggagctggt ggagccgctg 2100 acacctagcg gagcgatgcc caaccaggcg cagatgcgga tcctgaaaga gacggagctg 2160 aggaaggtga aggtgcttgg atctggcgct tttggcacag tctacaaggg catctggatc 2220 cctgatgggg agaatgtgaa aattccagtg gccatcaaag tgttgaggga aaacacatcc 2280 cccaaagcca acaaagaaat cttagacgaa gcatacgtga tggctggtgt gggctcccca 2340 tatgtctccc gccttctggg catctgcctg acatccacgg tgcagctggt gacacagctt 2400 atgccctatg gctgcctctt agaccatgtc cgggaaaacc gcggacgcct gggctcccag 2460 gacctgctga actggtgtat gcagattgcc aaggggatga gctacctgga ggatgtgcgg 2520 ctcgtacaca gggacttggc cgctcggaac gtgctggtca agagtcccaa ccatgtcaaa 2580 attacagact tcgggctggc tcggctgctg gacattgacg agacagagta ccatgcagat 2640 gggggcaagg tgcccatcaa gtggatggcg ctggagtcca ttctccgccg gcggttcacc 2700 caccagagtg atgtgtggag ttatggtgtg actgtgtggg agctgatgac ttttggggcc 2760 aaaccttacg atgggatccc agcccgggag atccctgacc tgctggaaaa gggggagcgg 2820 ctgccccagc cccccatctg caccattgat gtctacatga tcatggtcaa atgttggatg 2880 attgactctg aatgtcggcc aagattccgg gagttggtgt ctgaattctc ccgcatggcc 2940 agggaccccc agcgctttgt ggtcatccag aatgaggact tgggcccagc cagtcccttg 3000 gacagcacct tctaccgctc actgctggag gacgatgaca tgggggacct ggtggatgct 3060 gaggagtatc tggtacccca gcagggcttc ttctgtccag accctgcccc gggcgctggg 3120 ggcatggtcc accacaggca ccgcagctca tctaccagga gtggcggtgg ggacctgaca 3180 ctagggctgg agccctctga agaggaggcc cccaggtctc cactggcacc ctccgaaggg 3240 gctggctccg atgtatttga tggtgacctg ggaatggggg cagccaaggg gctgcaaagc 3300 ctccccacac atgaccccag ccctctacag cggtacagtg aggaccccac agtacccctg 3360 ccctctgaga ctgatggcta cgttgccccc ctgacctgca gcccccagcc tgaatatgtg 3420 aaccagccag atgttcggcc ccagccccct tcgccccgag agggccctct gcctgctgcc 3480 cgacctgctg gtgccactct ggaaagggcc aagactctct ccccagggaa gaatggggtc 3540 gtcaaagacg tttttgcctt tgggggtgcc gtggagaacc ccgagtactt gacaccccag 3600 ggaggagctg cccctcagcc ccaccctcct cctgccttca gcccagcctt cgacaacctc 3660 tattactggg accaggaccc accagagcgg ggggctccac ccagcacctt caaagggaca 3720 cctacggcag agaacccaga gtacctgggt ctggacgtgc cagtgtga 3768 53 1986 DNA Homo sapiens ERBB3 XM006723 53 atgcacaact tcagtgtttt ttccaatttg cggggcttct cattgttgat catgaagaac ctgaaggaaa ttagtgctgg gcgtatctat cactctttga actggaccaa ggtgcttcgg cataatcggc cgcgcagaga ctgcgtggca tctgggggat gctggggccc aggccctggt ggaggtgtct gtgtgaccca ctgcaacttt gaggccgaat gcttctcctg ccacccggaa aatggctcgg gctctgatac ttgtgctcaa gtgagcagct gcccccatgg agtcctaggt acaaccattg gaggcagaag cctctacaac 60 ttgaatgtca catctctggg cttccgatcc 120 ataagtgcca ataggcagct ctgctaccac 180 gggcctacgg aagagcgact agacatcaag 240 gagggcaaag tgtgtgaccc actgtgctcc 300 cagtgcttgt cctgtcgaaa ttatagccga 360 ctgaatgggg agcctcgaga atttgcccat 420 tgccaaccca tggagggcac tgccacatgc 480 tgtgcccatt ttcgagatgg gccccactgt 540 gccaagggcc caatctacaa gtacccagat 600 gttcagaatg cttcaagact ttgacagtga tggcgtgggc agcatagagc gagacagagc ggagtgtgga gacaagagtg ctggaccatg gtcactcaat ctggggccac gaggaacatg agtcaggttc ctgctataca gggaaataca accttcgggg aagggggagc aagtgttgga accaggatgg atagcccctg gagccagaac acactgggct agccttttaa ccttag aatgtcggcc gtttaggaca tagcaggatt gccggattca ctctggaccc taaggaagct tccctgaggg gacggcagag cccacattgt atttgcctct agctgctgct gtatggtgca aggtggcaga gtgaggccaa cacaccagag cagagcccta ggttggcaca tgattgatga cccgagaccc ggccagagcc tagacctaga ccgccctcag gtccatcatc ctgccatgag aacactggtg ggtagtgatt gaataaaagg cagtgagaag taaagtgctt tgaatcaatc ttttcaagct aaggctgctg gggttctctg caactgggga tagaaacctg ttttggtgtg gactccaatt tgatgtctgg tgcagggcta gccccagatc gaacattcgc accacggtat ccatggtctg cctagacttg cctaccagtt tggatacatg aactgcaccc ctgatcggca ttcatgatgc gctatgaggc gctaacaaag ggctcgggtg aagattccag gtgacagatc ggactatgcc ctggatcatg gtacaaattg gctgcccgaa gctgacctgc aagtggatgg agctatggtg cgattggctg tgcacaattg ccaaccttta ctggtcataa acaaacaaga gaagcagagg ggaacactta cccatgaacc aggggtgtaa aaacccatct tgggcggcac gatacttgga tcttggccag tctttggaac tctgcattaa atatgctggc cagggtcatc tgagacaaca ccaagggaat acgtgctact tgcctcctga cccttgagag tgacagtttg aagtaccaga atgtctacat aagaactagc agagagagag agctagagga aggacaacct atcggccacg agggtaatct aggaccagag 660 gacaatggct 720 ttttctctac 780 acggggtgag 840 aatcttcaaa 900 tgtgcacaaa 960 agtcattgag 1020 cattggcagc 1080 tctgcagctt 1140 ccggggggca 1200 gtactacctt 1260 caagtcaccc 1320 tgataagcag 1380 tatccacttt 1440 ggagttgatg 1500 cctgctagag 1560 ggtgatggtc 1620 caatgagttc 1680 tgggcctgga 1740 agtagagctg 1800 ggcaaccacc 1860 tgggagccag 1920 tggggttctt 1980 1986 54 1437 DNA Homo sapiens ERBB4 XM002260 54 atgatgtacc tggaagaaag acgactcgtt gtgaaatctc caaaccatgt gaaaatcaca gatgaaaaag agtacaatgc tgatggagga tgtatacatt acaggaaatt cacccatcag tgggaactga tgacctttgg aggaaaaccc gatttattag agaaaggaga acgtttgcct atggtcatgg tcaaatgttg gatgattgat gctgctgagt tttcaaggat ggctcgagac gatcgtatga agcttcccag tccaaatgac gaggatttgg aagatatgat ggatgctgag ccacctccca tctatacttc cagagcaaga agccctcctc ctgcctacac ccccatgtca tttgctgctg aacaaggagt gtctgtgccc gctcctgtgg cacagggtgc tactgctgag ctacgcaagc cagtggcacc ccatgtccaa gaccccaccg tgtttgcccc agaacggagc atgactccta tgcgagacaa acccaaacaa tttgtttcte ggagaaaaaa tggagacctt gcatccaatg gtccacccaa ggccgaggat acctttgcca acaccttggg aaaagctgag gagaaggcca agaaagcgtt tgacaaccct agcacccttc agcacccaga ctacctgcag aatgggcgga tccggcctat tgtggcagag aagccaggca ctgtgctgcc gcctccacct catcgggatt tggcagcccg taatgtctta 60 gattttgggc tagccagact cttggaagga 120 aagatgccaa ttaaatggat ggctctggag 180 agtgacgttt ggagctatgg agttactata 240 tatgatggaa ttccaacgcg agaaatccct 300 cagcctccca tctgcactat tgacgtttac 360 gctgacagta gacctaaatt taaggaactg 420 cctcaaagat acctagttat teagggtgat 480 agcaagttct ttcagaatct cttggatgaa 540 gagtacttgg tccctcaggc tttcaacatc 600 attgactcga ataggagtga aattggacac 660 ggaaaccagt ttgtataccg agatggaggt 720 tacagagccc caactagcac aattccagaa 780 atttttgatg actcctgctg taatggcacc 840 gaggacagta gcacccagag gtacagtgct 900 ccacgaggag agctggatga ggaaggttac 960 gaatacctga atccagtgga ggagaaccct 1020 caagcattgg ataatcccga atatcacaat 1080 gagtatgtga atgagccact gtacctcaac 1140 tacctgaaga acaacatact gtcaatgcca 1200 gactactgga accacagcct gccacctcgg 1260 gagtacagca caaaatattt ttataaacag 1320 aatcctgaat acctctctga gttctccctg 1380 tacagacacc ggaatactgt ggtgtaa 1437 55 627 DNA Homo sapiens FGF10 NM004465 55 atgtggaaat ggatactgac acattgtgcc tgctgctgct ttttgttgct gttcttggtg ggtcaggaca tggtgtcacc agaggccacc tccagcgcgg gaaggcatgt gcggagctac aagctattct ctttcaccaa gtactttctc accaagaagg agaactgccc gtacagcatc gttgccgtca aagccattaa cagcaactat tatggctcaa aagaatttaa caatgactgt tacaatacct atgcatcatt taactggcag aatggaaaag gagctccaag gagaggacag tttcttccaa tggtggtaca ctcatag tcagcctttc cccacctgcc cggctgctgc 60 tcttccgtcc ctgtcacctg ccaagccctt 120 aactcttctt cctcctcctt ctcctctcct 180 aatcaccttc aaggagatgt ccgctggaga 240 aagattgaga agaacgggaa ggtcagcggg 300 ctggagataa catcagtaga aatcggagtt 360 tacttagcca tgaacaagaa ggggaaactc 420 aagctgaagg agaggataga ggaaaatgga 480 cataatggga ggcaaatgta tgtggcattg 540 aaaacacgaa ggaaaaacac ctctgctcac 600 627 56 679 DNA Homo sapiens FGF11 XM008660 56 aatggcggcg ctggccagta gcctgatccg gcagaagcgg gaggtccgcg agcccggggg 60 cagccggccg gtgtcggcgc agcggcgcgt gtgtccccgc ggcaccaagt ccctttgcca 120 gaagcagctc ctcatcctgc tgtccaaggt gcgactgtgc ggggggcggc ccgcgcggcc 180 ggaccgcggc ccggagcctc agctcaaagg catcgtcacc aaactgttct gccgccaggg 240 tttctacctc caggcgaatc ccgacggaag catccagggc accccagagg ataccagctc 300 cttcacccac ttcaacctga tccctgtggg cctccgtgtg gtcaccatcc agagcgccaa 360 gctgggtcac tacatggcca tgaatgctga gggactgctc tacagttcgc cgcatttcac 420 agctgagtgt cgctttaagg agtgtgtctt tgagaattac tacgtcctgt acgcctctgc 480 tctctaccgc cagcgtcgtt ctggccgggc ctggtacctc ggcctggaca aggagggcca 540 ggtcatgaag ggaaaccgag ttaagaagac caaggcagct gcccactttc tgcccaagct 600 cctggaggtg gccatgtacc aggagccttc tctccacagt gtccccgagg cctccccttc 660 cagtccccct gccccctga 679 57 732 DNA Homo sapiens FGF12 NM021032 57 atggctgcgg cgatagccag ctccttgatc cggcagaagc ggcaggcgag ggagtccaac 60 agcgaccgag tgtcggcctc caagcgccgc tccagcccca gcaaagacgg gcgctccctg 120 tgcgagaggc acgtcctcgg ggtgttcagc aaagtgcgct tctgcagcgg ccgcaagagg 180 ccggtgaggc ggagaccaga accccagctc aaagggattg tgacaaggtt attcagccag 240 cagggatact tcctgcagat gcacccagat ggtaccattg atgggaccaa ggacgaaaac 300 agcgactaca ctctcttcaa tctaattccc gtgggcctgc gtgtagtggc catccaagga 360 gtgaaggcta gcctctatgt ggccatgaat ggtgaaggct atctctacag ttcagatgtt 420 ttcactccag aatgcaaatt caaggaatct gtgtttgaaa actactatgt gatctattct 480 tccacactgt accgccagca agaatcaggc cgagcttggt ttctgggact caataaagaa 540 ggtcaaatta tgaaggggaa cagagtgaag aaaaccaagc cctcatcaca ttttgtaccg 600 aaacctattg aagtgtgtat gtacagagaa ccatcgctac atgaaattgg agaaaaacaa 660 gggcgttcaa ggaaaagttc tggaacacca accatgaatg gaggcaaagt tgtgaatcaa 720 gattcaacat ag 732 58 738 DNA Homo sapiens FGF13 XM010269 58 atggcggcgg aaatccaacg aacaagttaa agaccagagc ttgcagctgc ctgtttaacc ctgtacttgg tgcaaattca cgtcagcagc aaaggcaacc gtggccatgt gggaccccaa cacaatgaat ctatcgccag cctgcaagtg atgtcttttc ctcagcttaa aggcggatgg tcatccctgt caatgaacag aagaatcagt agtcaggccg atgtgaagaa acaaggagcc ccaagagcag caacgtag ctcgctcatc tgtcagcagc ccgggtcaaa gggtatagtt aaccattgat gggtctgcga tgagggatac gtttgaaaat agggtggtat gaacaagcct atcactgcac aagtgtctct cgtcagaaga cccagcaaag ctcttcggct accaagctat ggcaccaaag gtggtggcta ttgtacacct tattatgtga ctgggtctga gcagctcatt gatctcacgg ggcgtgctga ggcaagcccg gcaagaccag ccaagaagag acagccgaca atgaggacag tccaaggagt cggaactttt catattcatc acaaagaagg ttctgcctaa agttctcccg acggaggcaa cgagcgcgag 60 ctgcgacaaa 120 gcgcagaaga 180 aggctaccac 240 cacttacact 300 tcaaaccaag 360 cacacctgag 420 aatgatatac 480 agagatcatg 540 accactgaaa 600 atctggaagc 660 atccatgagc 720 738 59 624 DNA Homo sapiens FGF16 NM003868 59 atggcagagg tctctgggga atcgagggga cggcgccgcc gtgcacggga gtggggctga ggagaactct gaaaactggt tattacgtgg cagaaattca agagacctct tggggggcgt acgtgccctt agctgcagcg agctctactg cccgccacga tcagcatccg atgggtcgaa acaacaccta ccctgaacaa ctcacttttt ttcactatag cttcgcctcc agctgactcc tggctcaccc ccgcaccggc ccacagccgc gggagtggac gaaactcaca tgcctcaacc agatggctca acccaggcct gtaa ttggactggg ccaggtttcc acagacttcg ttccacctgg ttcggaatcc tctggcctgt cgtgaatgtg ttgtacaaac ccccgggagg gtagatcctt atctacacgg tgaacgagcg cccacctgaa agatcttccc tggagtttat acctaggaat ttttccggga attcggactc gatacaggac ctaagttgcc cttctcctcg 60 cctgggccaa 120 ggggatcctg 180 caacggcacg 240 cagcctggct 300 gaatgagcga 360 acagtttgaa 420 agagagacag 480 taaacgacac 540 ctccatgtcc 600 624 60 651 DNA Homo sapiens FGF17 XM005316 60 atgggagccg cccgcctgct gcccaacctc actctgtgct tacagctgct gattctctgc 60 tgtcaaactc agggggagaa tcacccgtct ggcgccatga ccgaccagct gagcaggcgg accagtggca agcacgtgca ggtcaccggg aacaagtttg ccaagctcat agtggagacg ggggctgaga gtgagaagta catctgtatg agcgggaaga gcaaagactg cgtgttcacg ttccagaacg cccggcacga gggctggttc caggcttccc gcagccgcca gaaccagcgc ggccagctgc ccttccccaa ccacgccgag gcccccaccc gccggaccaa gcgcacacgg cctaatttta accagtacgt gagggaccag 120 cagatccgcg agtaccaact ctacagcagg 180 cgtcgcatct ccgccaccgc cgaggacggc 240 gacacgtttg gcagccgggt tcgcatcaaa 300 aacaagaggg gcaagctcat cgggaagccc 360 gagatcgtgc tggagaacaa ctatacggcc 420 atggccttca cgcggcaggg gcggccccgc 480 gaggcccact tcatcaagcg cctctaccaa 540 aagcagaagc agttcgagtt tgtgggctcc 600 cggccccagc ccctcacgta g 651 61 624 DNA Homo sapiens FGF18 AF075292 61 atgtattcag cgccctccgc ctgcacttgc caggtacagg tgctggttgc cgaggagaac acgcgggctc gggacgatgt gagccgtaag accagtggga aacacatcca ggtcctgggc gacaagtatg cccagctcct agtggagaca ggcaaggaga cggaattcta cctgtgcatg gatggcacca gcaaggagtg tgtgttcatc ctgatgtcgg ctaagtactc cggctggtac aagggcccca agacccggga gaaccagcag gggcagccgg agcttcagaa gcccttcaag ctgtgtttac acttcctgct gctgtgcttc 60 gtggacttcc gcatccacgt ggagaaccag 120 cagctgcggc tgtaccagct, ctacagccgg 180 cgcaggatca gtgcccgcgg cgaggatggg 240 gacaccttcg gtagtcaagt ccggatcaag 300 aaccgcaaag gcaagctcgt ggggaagccc 360 gagaaggttc tggagaacaa ctacacggcc 420 gtgggcttca ccaagaaggg gcggccgcgg 480 gacgtgcatt tcatgaagcg ctaccccaag 540 tacacgacgg tgaccaagag gtcccgtcgg 600 atccggccca cacaccctgc ctag 624 62 651 DNA Homo sapiens FGF19 AF110400 62 atgcggagcg ggtgtgtggt ggtccacgta tggatcctgg ccggcctctg gctggccgtg 60 gccgggcgcc ccctcgcctt ctcggacgcg gggccccacg tgcactacgg ctggggcgac 120 cccatccgcc tgcggcacct gtacacctcc ggcccccacg ggctctccag ctgcttcctg 180 cgcatccgtg ccgacggcgt cgtggactgc gcgcggggcc agagcgcgca cagtttgctg 240 gagatcaagg cagtcgctct gcggaccgtg gccatcaagg gcgtgcacag cgtgcggtac 300 ctctgcatgg gcgccgacgg caagatgcag gggctgcttc agtactcgga ggaagactgt 360 gctttcgagg aggagatccg cccagatggc tacaatgtgt accgatccga gaagcaccgc 420 ctcccggtct ccctgagcag tgccaaacag cggcagctgt acaagaacag aggctttctt 480 ccactctctc atttcctgcc catgctgccc atggtcccag aggagcctga ggacctcagg 540 ggccacttgg aatctgacat gttctcttcg cccctggaga ccgacagcat ggacccattt 600 gggcttgtca ccggactgga ggccgtgagg agtcccagct ttgagaagta a 651 63 468 DNA Homo sapiens 63 atggctgaag gggaaatcac caccttcaca gccctgaccg agaagtttaa tctgcctcca 60 gggaattaca agaagcccaa actcctctac tgtagcaacg ggggccactt cctgaggatc 120 cttccggatg gcacagtgga tgggacaagg gacaggagcg accagcacat tcagctgcag 180 ctcagtgcgg aaagcgtggg ggaggtgtat ataaagagta ccgagactgg ccagtacttg 240 gccatggaca ccgacgggct tttatacggc tcacagacac caaatgagga atgtttgttc 300 ctggaaaggc tggaggagaa ccattacaac acctatatat ccaagaagca tgcagagaag 360 aattggtttg ttggcctcaa gaagaatggg agctgcaaac gcggtcctcg gactcactat 420 ggccagaaag caatcttgtt tctccccctg ccagtctctt ctgattaa 468 64 636 DNA Homo sapiens FGF20 NM019851 64 atggctccct tagccgaagt cgggggcttt gtgggttcgc atttcctgtt gcctcctgcc aggagcgcgg cggagcggag cgcccgcggc cacggcatcc tgcgccgccg gcagctctat cccgacggca gcgtgcaggg cacccggcag atcagtgtgg cagtgggact ggtcagtatt atgaatgaca aaggagaact ctatggatca gagcagtttg aagagaactg gtataacacc actggccgca ggtattttgt ggcacttaac tccaagaggc atcagaaatt tacacatttc ccagaattgt acaaggacct actgatgtac ctgggcggcc tggagggctt gggccagcag 60 ggggagcggc cgccgctgct gggcgagcgc 120 gggccggggg ctgcgcagct ggcgcacctg 180 tgccgcaccg gcttccacct gcagatcctg 240 gaccacagcc tcttcggtat cttggaattc 300 agaggtgtgg acagtggtct ctatcttgga 360 gagaaactta cttccgaatg catctttagg 420 tattcatcta acatatataa acatggagac 480 aaagacggaa ctccaagaga tggcgccagg 540 ttacctagac cagtggatcc agaaagagtt 600 acttga 636 65 630 DNA Homo sapiens FGF21 XM009100 atggactcgg acgagaccgg gttcgagcac tcaggactgt gggtttctgt gctggctggt 60 cttctgctgg gagcctgcca ggcacacccc atccctgact ccagtcctct cctgcaattc 120 gggggccaag tccggcagcg gtacctctac acagatgatg cccagcagac agaagcccac 180 ctggagatca gggaggatgg gacggtgggg ggcgctgctg accagagccc cgaaagtctc 240 ctgcagctga aagccttgaa gccgggagtt attcaaatct tgggagtcaa gacatccagg 300 ttcctgtgcc agcggccaga tggggccctg tatggatcgc tccactttga ccctgaggcc 360 tgcagcttcc gggagctgct tcttgaggac ggatacaatg tttaccagtc cgaagcccac 420 ggcctcccgc tgcacctgcc agggaacaag tccccacacc gggaccctgc accccgagga 480 ccagctcgct tcctgccact accaggcctg ccccccgcac tcccggagcc acccggaatc 540 ctggcccccc agccccccga tgtgggctcc tcggaccctc tgagcatggt gggaccttcc 600 cagggccgaa gccccagcta cgcttcctga 630 66 513 DNA Homo sapiens FGF22 XM009271 66 atgcgccgcc gcctgtggct gggcctggcc tggctgctgc tggcgcgggc gccggacgcc 60 gcgggaaccc cgagcgcgtc gcggggaccg cgctggcggc gcctcttctc ctccactcac gtgcagggca cccgctggcg ccacggccag gtgggcgtcg tggtcatcaa agcagtgtcc ggccgcctct acgggtcgcg actctacacc gagaacggcc acaacaccta cgcctcacag ctggcgctgg acaggagggg ggggccccgg tccgcccact tcctgcccgt cctggtctcc cgcagctacc cgcacctgga gggcgacgtg 120 ttcttcctgc gcgtggatcc cggcggccgc 180 gacagcatcc tggagatccg ctctgtacac 240 tcaggcttct acgtggccat gaaccgccgg 300 gtggactgca ggttccggga gcgcatcgaa 360 cgctggcgcc gccgcggcca gcccatgttc 420 ccaggcggcc ggacgcggcg gtaccacctg 480 tga 513 67 621 DNA Homo sapiens FGF4 NM002007 67 atgtcggggc ccmacggc cgcggtagcg gcgccctggg cgggccgagg gggcgccgcc gccgagctgg agcgccgctg ggagagcctg gcagcgcagc ccaaggaggc ggccgtccag aagcggctgc ggcggctcta ctgcaacgtg gacggccgca tcggcggcgc gcacgcggac gtggagcggg gcgtggtgag catcttcggc agcaagggca agctctatgg ctcgcccttc ctccttccca acaactacaa cgcctacgag ctgagcaaga atgggaagac caagaagggg cacttcctcc ccaggctgtg a ctgctcccgg cggtcctgct ggccttgctg 60 gcacccactg cacccaacgg cacgctggag 120 gtggcgctct cgttggcgcg cctgccggtg 180 agcggcgccg gcgactacct gctgggcatc 240 ggcatcggct tccacctcca ggcgctcccc 300 acccgcgaca gcctgctgga gctctcgccc 360 gtggccagcc ggttcttcgt ggccatgagc 420 ttcaccgatg agtgcacgtt caaggagatt 480 tcctacaagt accccggcat gttcatcgcc 540 aaccgagtgt cgcccaccat gaaggtcacc 600 621 68 597 DNA Homo sapiens FGF6 NM020996 68 atgtcccggg ctagtgggca tcgaggggct ggggtgaact aacgtgggca gaggagaacc tttggagtga cccagcttcc tacgagtcag cggggcagca gagcaggacg tggtggtgcc ggggcaccct gggaaagtgg tcggctttca cctacagcct gaagtgccct aagaagaatg acttgtacca aggtgtcccc tctgcagggc ctcgcctgca gctgtccagg ctatttggtg cctccaggtg gctggaaatt cttcgttgcc caagttcaga agggacctac gatcatgact acgctgtggg ggcacccgtg tctcgcgcgg gggatcaagc ctccccgacg tccactgtgg atgaacagta gaaaccctcc attgccctga gtcactcatt ctctcgtctt ccaacaacac ggctagctgg ggcagcggag gccggatcag agcgaggcgt aaggaagatt tgcccaacaa gcaaatacgg tccttcccag cctaggcatc 60 gctgctggac 120 agagattgcc 180 gctctactgc 240 cgggacccac 300 ggtgagtctc 360 gtacgcaacg 420 ttacaatgcc 480 acgggtaaag 540 gatctaa 597 69 150 DNA Homo sapiens FGF7 XM007559 69 atgtcttggc aatgcacttc atacacaatg actaatctat actgtgatga tttgactcaa 60 aaggagaaaa gaaattatgt agttttcaat tctgattcct tggaaagctt tgtgcaaaat atacatataa attcaccttt tgtttatgaa 120 150 70 628 DNA Homo sapiens FGF9 XM007105 70 gatggctccc gaatgtgccc cgaagcaggg tctcaggcgg tactatccag agcagtgggc gaagggggag cgaagaaaac gcgatactat gcaccagaaa gtataaggat ttaggtgaag gtgttgccgg gggctcccca aggcagctat ggaaccagga ctggtcagca ctgtatggat tggtataata gttgcattaa ttcacacatt attctaagcc ttgggaacta tggacagccc ggggacccgc actgcaggac aagaccacag ttcgaggcgt cagaaaaact cgtactcatc ataaagatgg ttttacctag aaagttga tttcggtgtg ggttttgtta agtcacggac tggatttcac ccgatttggc ggacagtgga aacccaagag aaacctatat gaccccgaga accagtggac caggatgcgg agtgaccacc ttggatcatt ttagaaatct attctggaat ctctacctcg tgtgtattca aagcacgtgg gaagggacta cccgacaaag taccgtttgg 60 tgggtcagtc 120 taaaggggat 180 tccccaatgg 240 ttatcagtat 300 ggatgaatga 360 gagaacagtt 420 acactggaag 480 ggactaaacg 540 tacctgaact 600 628 71 2469 DNA Homo sapiens FGFR1 NM000604 71 atgtggagct ggaagtgcct cctcttctgg gctgtgctgg tcacagccac actctgcacc 60 gctaggccgt ccccgacctt gcctgaacaa gcccagccct ggggagcccc tgtggaagtg 120 gagtccttcc tggtccaccc cggtgacctg ctgcagcttc gctgtcggct gcgggacgat 180 gtgcagagca tcaactggct gcgggacggg gtgcagctgg cggaaagcaa ccgcacccgc 240 atcacagggg aggaggtgga ggtgcaggac tccgtgcccg cagactccgg cctctatgct 300 tgcgtaacca gcagcccctc gggcagtgac accacctact tctccgtcaa tgtttcagat 360 gctctcccct cctcggagga tgatgatgat gatgatgact cctcttcaga ggagaaagaa 420 acagataaca ccaaaccaaa ccgtatgccc gtagctccat attggacatc cccagaaaag 480 atggaaaaga aattgcatgc agtgccggct gccaagacag tgaagttcaa atgcccttcc 540 agtgggaccc caaaccccac actgcgctgg ttgaaaaatg gcaaagaatt caaacctgac 600 cacagaattg gaggctacaa ggtccgttat gccacctgga gcatcataat ggactctgtg 660 gtgccctctg acaagggcaa ctacacctgc attgtggaga atgagtacgg cagcatcaac 720 cacacatacc agctggatgt cgtggagcgg tcccctcacc ggcccatcct gcaagcaggg 780 ttgcccgcca acaaaacagt ggccctgggt agcaacgtgg agttcatgtg taaggtgtac 840 agtgacccgc agccgcacat ccagtggcta aagcacatcg aggtgaatgg gagcaagatt 900 ggcccagaca acctgcctta tgtccagatc ttgaagactg ctggagttaa taccaccgac 960 aaagagatgg aggtgcttca cttaagaaat gtctcctttg aggacgcagg ggagtatacg 1020 tgcttggcgg gtaactctat cggactctcc catcactctg catggttgac cgttctggaa 1080 gccctggaag agaggccggc agtgatgacc tcgcccctgt acctggagat catcatctat 1140 tgcacagggg ccttcctcat ctcctgcatg gtggggtcgg tcatcgtcta caagatgaag 1200 agtggtacca agaagagtga cttccacagc cagatggctg tgcacaagct ggccaagagc 1260 atccctctgc gcagacaggt aacagtgtct gctgactcca gtgcatccat gaactctggg 1320 gttcttctgg ttcggccatc acggctctcc tccagtggga ctcccatgct agcaggggtc 1380 tctgagtatg agcttcccga agaccctcgc tgggagctgc ctcgggacag actggtctta 1440 ggcaaacccc tgggagaggg ctgctttggg caggtggtgt tggcagaggc tatcgggctg 1500 gacaaggaca aacccaaccg tgtgaccaaa gtggctgtga agatgttgaa gtcggacgca 1560 acagagaaag acttgtcaga cctgatctca gaaatggaga tgatgaagat gatcgggaag 1620 cataagaata tcatcaacct gctgggggcc tgcacgcagg atggtccctt gtatgtcatc 1680 gtggagtatg cctccaaggg caacctgcgg gagtacctgc aggcccggag gcccccaggg 1740 ctggaatact gctacaaccc cagccacaac ccagaggagc agctctcctc caaggacctg 1800 gtgtcctgcg cctaccaggt ggcccgaggc atggagtatc tggcctccaa gaagtgcata 1860 caccgagacc tggcagccag gaatgtcctg gtgacagagg acaatgtgat gaagatagca 1920 gactttggcc tcgcacggga cattcaccac atcgactact ataaaaagac aaccaacggc 1980 cgactgcctg tgaagtggat ggcacccgag gcattatttg accggatcta cacccaccag 2040 agtgatgtgt ggtetttcgg ggtgctcctg tgggagatct tcactctggg cggctcccca 2100 taccccggtg tgcctgtgga ggaacttttc aagctgctga aggagggtca ccgcatggac 2160 aagcccagta actgcaccaa cgagctgtac atgatgatgc gggactgctg gcatgcagtg 2220 ccctcacaga gacccacctt caagcagctg gtggaagacc tggaccgcat cgtggccttg 2280 acctccaacc aggagtacct ggacctgtcc atgcccctgg accagtactc ccccagcttt 2340 cccgacaccc ggagctctac gtgctcctca ggggaggatt ccgtcttctc tcatgagccg 2400 ctgcccgagg agccctgcct gccccgacac ccagcccagc ttgccaatgg cggactcaaa 2460 cgccgctga 2469 72 2409 DNA Homo sapiens FGFR4 XM003910 72 atgcggctgc tgctggccct gttgggggtc ctgctgagtg tgcctgggcc tccagtcttg 60 tccctggagg cctctgagga agtggagctt gagccctgcc tggctcccag cctggagcag 120 caagagcagg agctgacagt agcccttggg cagcctgtgc ggctgtgctg tgggcgggct 180 gagcgtggtg gccactggta caaggagggc agtcgcctgg cacctgctgg ccgtgtacgg 240 ggctggaggg gccgcctaga gattgccagc ttcctacctg aggatgctgg ccgctacctc 300 tgcctggcac gaggctccat gatcgtcctg cagaatctca ccttgattac aggtgactcc 360 ttgacctcca gcaacgatga tgaggacccc aagtcccata gggacctctc gaataggcac 420 agttaccccc agcaagcacc ctactggaca cacccccagc gcatggagaa gaaactgcat 480 gcagtacctg cggggaacac cgtcaagttc cgctgtccag ctgcaggcaa ccccacgccc 540 accatccgct ggcttaagga tggacaggcc tttcatgggg agaaccgcat tggaggcatt 600 cggctgcgcc atcagcactg gagtctcgtg atggagagcg tggtgccctc ggaccgcggc 660 acatacacct gcctggtaga gaacgctgtg ggcagcatcc gttataacta cctgctagat 720 gtgctggagc ggtccccgca ccggcccatc ctgcaggccg ggctcccggc caacaccaca 780 gccgtggtgg gcagcgacgt ggagctgctg tgcaaggtgt acagcgatgc ccagccccac 840 atccagtggc tgaagcacat cgtcatcaac ggcagcagct tcggagccga cggtttcccc 900 tatgtgcaag tcctaaagac tgcagacatc aatagctcag aggtggaggt cctgtacctg 960 cggaacgtgt cagccgagga cgcaggcgag tacacctgcc tcgcaggcaa ttccatcggc 1020 ctctcctacc agtctgcctg gctcacggtg ctgccagagg aggaccccac atggaccgca 1080 gcagcgcccg aggccaggta tacggacatc atcctgtacg cgtcgggctc cctggccttg 1140 gctgtgctcc tgctgctggc caggctgtat cgagggcagg cgctccacgg ccggcacccc 1200 cgcccgcccg ccactgtgca gaagctctcc cgcttccctc tggcccgaca gttctccctg 1260 gagtcaggct cttccggcaa gtcaagctca tccctggtac gaggcgtgcg tctctcctcc 1320 agcggccccg ccttgctcgc cggcctcgtg agtctagatc tacctctcga cccactatgg 1380 gagttccccc gggacaggct ggtgcttggg aagcccctag gcgagggctg ctttggccag 1440 gtagtacgtg cagaggcctt tggcatggac cctgcccggc ctgaccaagc cagcactgtg 1500 gccgtcaaga tgctcaaaga caacgcctct gacaaggacc tggccgacct ggtctcggag 1560 atggaggtga tgaagctgat cggccgacac aagaacatca tcaacctgct tggtgtctgc 1620 acccaggaag ggcccctgta cgtgatcgtg gagtgcgccg ccaagggaaa cctgcgggag 1680 ttcctgcggg c ccggcgccc cccaggcccc gacctcagcc ccgacggtcc tcggagcagt 1740 gaggggccgc tctccttccc agtcctggtc tcctgcgcct accaggtggc ccgaggcatg 1800 cagtatctgg agtcccggaa gtgtatccac cgggacctgg ctgcccgcaa tgtgcggtg 1860 actgaggaca atgtgatgaa gattgctgac tttgggctgg cccgcggcgt ccaccacatt 1920 gactactata agaaaaccag caacggccgc ctgcctgtga agtggatggc gcccgaggcc 1980 ttgtttgacc gggtgtacac acaccagagt gacgtgtggt cttttgggat cctgctatgg 2040 gagatcttca ccctcggggg ctccccgtat cctggcatcc cggtggagga gctgttctcg 2100 ctgctgcggg agggacatcg gatggaccga cccccacact gccccccaga gctgtacggg 2160 ctgatgcgtg agtgctggca cgcagcgccc tcccagaggc ctaccttcaa gcagctggtg 2220 gaggcgctgg acaaggtcct gctggccgtc tctgaggagt acctcgacct ccgcctgacc 2280 ttcggaccct attccccctc tggtggggac gccagcagca cctgctcctc cagcgattct 2340 gtcttcagcc acgaccccct gccattggga tccagctcct tccccttcgg gtctggggtg 2400 cagacatga 2409 73 1695 DNA Homo sapiens MT2MMP D86331 73 atgaagcggc cccgctgtgg ggtgccagac cagttcgggg tacgagtgaa agccaacctg 60 cggcggcgtc ggaagcgcta cgccctcacc gggaggaagt ggaacaacca ccatctgacc 120 tttagcatcc agaactacac ggagaagttg ggctggtacc actcgatgga ggcggtgcgc 180 agggccttcc gcgtgtggga gcaggccacg cccctggtct tccaggaggt gccctatgag 240 gacatccggc tgcggcgaca gaaggaggcc gacatcatgg tactctttgc ctctggcttc 300 cacggcgaca gctcgccgtt tgatggcacc ggtggctttc tggcccacgc ctatttccct 360 ggccccggcc taggcgggga cacccatttt gacgcagatg agccctggac cttctccagc 420 actgacctgc atggaaacaa cctcttcctg gtggcagtgc atgagctggg ccacgcgctg 480 gggctggagc actccagcaa ccccaatgcc atcatggcgc cgttctacca gtggaaggac 540 gttgacaact tcaagctgcc cgaggacgat ctccgtggca tccagcagct ctacggtacc 600 ccagacggtc agccacagcc tacccagcct ctccccactg tgacgccacg gcggccaggc 660 cggcctgacc accggccgcc ccggcctccc cagccaccac ccccaggtgg gaagccagag 720 cggcccccaa agccgggccc cccagtccag ccccgagcca cagagcggcc cgaccagtat 780 ggccccaaca tctgcgacgg ggactttgac acagtggcca tgcttcgcgg ggagatgttc 840 gtgttcaagg gccgctggtt ctggcgagtc cggcacaacc gcgtcctgga caactatccc 900 atgcccatcg ggcacttctg gcgtggtctg cccggtgaca tcagtgctgc ctacgagcgc 960 caagacggtc gttttgtctt tttcaaaggt gaccgctact ggctctttcg agaagcgaac 1020 ctggagcccg gctacccaca gccgctgacc agctatggcc tgggcatccc ctatgaccgc 1080 attgacacgg ccatctggtg ggagcccaca ggccacacct tcttcttcca agaggacagg 1140 tactggcgct tcaacgagga gacacagcgt ggagaccctg ggtaccccaa gcccatcagt 1200 gtctggcagg ggatccctgc ctcccctaaa ggggccttcc tgagcaatga cgcagcctac 1260 acctacttct acaagggcac caaatactgg aaattcgaca atgagcgcct gcggatggag 1320 cccggctacc ccaagtccat cctgcgggac ttcatgggct gccaggagca cgtggagcca 1380 ggcccccgat ggcccgacgt ggcccggccg cccttcaacc cccacggggg tgcagagccc 1440 ggggcggaca gcgcagaggg cgacgtgggg gatggggatg gggactttgg ggccggggte 1500 aacaaggaca ggggcagccg cgtggtggtg cagatggagg aggtggcacg gacggtgaac 1560 gtggtgatgg tgctggtgcc actgctgctg ctgctctgcg tcctgggcct cacctacgcg 1620 ctggtgcaga tgcagcgcaa gggtgcgcca cgtgtcctgc tttactgcaa gcgctcgctg 1680 caggagtggg tctga 1695 74 1824 DNA Homo sapiens MT3MMP D85511 74 atgatcttac tcacattcag cactggaaga cggttggatt tttttcttgc aaaccttgct ttggatttta tgtgctacag ttcaatgtgg aggtttggtt acaaaagtac ggctaccttc tcagtgctgc gctctgcaga gaccatgcag tctgccctag ggcattaaca tgacaggaaa agtggacaga aacacaattg tgcggtgtac ctgaccagac aagaggtagc tccaaatttc gcattgacag gacagaaatg gcagcacaag cacatcactt tcgtgcatca ttcgggggtg 60 tctgcggaac ggagcagtat 120 caccgactga ccccagaatg 180 ctgccatgca gcagttctat 240 actggatgaa gaagccccga 300 atattcgtcg aaagcgatat 360 acagtataaa gaacgtaact 420 xaaaagtag gagaccctga gactcgtaaa gctattcgcc gtgcctttga tgtgtggcag 480 latgtaactc ctctgacatt tgaagaagtt ccctacagtg aattagaaaa tggcaaacgt 540 ;atgtggata taaccattat ttttgcatct ggtttccatg gggacagctc tccctttgat 600 ggagagggag gatttttggc acatgcctac ttccctggac caggaattgg aggagatacc 660 cattttgact cagatgagcc atggacacta ggaaatccta atcatgatgg aaatgactta 720 tttcttgtag cagtccatga actgggacat gctctgggat tggagcattc caatgacccc 780 actgccatca tggctccatt ttaccagtac atggaaacag acaacttcaa actacctaat 840 gatgatttac agggcatcca gaagatatat ggtccacctg acaagattcc tccacctaca 900 agacctctac cgacagtgcc cccacaccgc tctattcctc cggctgaccc aaggaaaaat 960 gacaggccaa aacctcctcg gcctccaacc ggcagaccct cctatcccgg agccaaaccc 1020 aacatctgtg atgggaactt taacactcta gctattcttc gtcgtgagat gtttgttttc 1080 aaggaccagt ggttttggcg agtgagaaac aacagggtga tggatggata cccaatgcaa 1140 attacttact tctggcgggg cttgcctcct agtatcgatg cagtttatga aaatagcgac 1200 gggaattttg tgttctttaa aggtaacaaa tattgggtgt tcaaggatac aactcttcaa 1260 cctggttacc ctcatgactt gataaccctt ggaagtggaa ttccccctca tggtattgat 1320 tcagccattt ggtgggagga cgtcgggaaa acctatttct tcaagggaga cagatattgg 1380 agatatagtg aagaaatgaa aacaatggac cctggctatc ccaagccaat cacagtctgg 1440 aaagggatcc ctgaatctcc tcagggagca tttgtacaca aagaaaatgg ctttacgtat 1500 ttctacaaag gaaaggagta ttggaaattc aacaaccaga tactcaaggt agaacctgga 1560 tatccaagat ccatcctcaa ggattttatg ' ggctgtgatg gaccaacaga cagagttaaa 1620 gaaggacaca gcccaccaga tgatgtagac attgtcatcaa actggacaa cacagccagc 1680 actgtgaaag ccatagctat tgtcattccc tgcatcttgg ccttatgcct ccttgtattg 1740 gtttacactg tgttccagtt caagaggaaa ggaacacccc gccacatact gtactgtaaa 1800 cgctctatgc aagagtgggt gtga 1824 75 1818 DNA Homo sapiens MT4MMP AB021225 75 atgcggcgcc gcgcagcccg gggacccggc ctgccgctgc tgccgctgcc gctgctgctg gccgcgccgg aacccgcgcg gcgcgccgag aggttcggtt acctgccccc ggctgacccc ctgtctaagg ccatcacagc catgcagcag gacgaggcca ccctggccct gatgaaaacc ctgacccagg ctcgcaggag acgccaggct ctgtcgtgga gggtccggac gttcccacgg gcactcatgt actacgccct caaggtctgg gtggcgggca gcaccgccga catccagatc taccccttcg acgcccggcg gcaccgtgcc gccgggtaca cccactttaa cgatgacgag gggatggacc tgtttgcagt ggctgtccac gtggccgctg cacactccat catgcggccg cgctacgggc tcccctacga ggacaaggtg tctgtgtctc ccacggcgca gcccgaggag cggtccagcg ccccgcccag gaaggacgtg gtggcccaga tccggggtga agctttcttc cgggaccggc acctggtgtc cctgcagccg ccgctgcacc tggacagcgt ggacgccgtg ttctttaaag gagacaggta ctgggtgttc cgccccgtct ccgacttcag cctcccgcct cacaatgaca ggacttattt ctttaaggac aggcacatgg accccggcta ccccgcccag ctggacgacg ccatgcgctg gtccgacggt tggaaagtgc tggatggcga gctggaggtg gactggctgg tgtgtggaga ctcacaggcc ccgccgcccc cagggcccgg actctcgcgg 60 ctgctggcgc tggggacccg cgggggctgc 120 gacctcagcc tgggagtgga gtggctaagc 180 acaacagggc agctgcagac gcaagaggag 240 tttggtggcx tggaggccac cggcatcctg 300 ccacgctgct ccctgccaga cctccctgtc 360 ccagccccca ccaagtggaa caagaggaac 420 gactcaccac tggggcacga cacggtgcgt 480 agcgacattg cgcccctgaa cttccacgag 540 gacttctcca aggccgacca taacgacggc 600 cacgccttct tccccggcca ccaccacacc 660 gcctggacct tccgctcctc ggatgcccac 720 gagtttggcc acgccattgg gttaagccat 780 tactaccagg gcccggtggg tgacccgctg 840 cgcgtctggc agctgtacgg tgtgcgggag 900 cctcccctgc tgccggagcc cccagacaac 960 ccccacagat gcagcactca ctttgacgcg 1020 ttcaaaggca agtacttctg gcggctgacg 1080 gcacagatgc accgcttctg gcggggcctg 1140 tacgagcgca ccagcgacca caagatcgtc 1200 aaggacaata acgtagagga aggatacccg 1260 ggcggcatcg acgctgcctt ctcctgggcc 1320 cagctgtact ggcgctacga tgaccacacg 1380 agccccctgt ggaggggtgt ccccagcacg 1440 gcctcctact tcttccgtgg ccaggagtac 1500 gcacccgggt acccacagtc cacggcccgg 1560 gatggatctg tggctgcggg cgtggacgcg 1620 gcagaggggc cccgcgcccc tccaggacaa catgaccaga gccgctcgga ggacggttac 1680 gaggtctgct catgcacctc tggggcatcc tctcccccgg gggccccagg cccactggtg 1740 gctgccacca tgctgctgct gctgccgcca ctgtcaccag gcgccctgtg gacagcggcc 1800 caggccctga cgctatga 1818 76 1938 DNA Homo sapiens MT5MMP AB021227 76 atgccgagga gccggggcgg ccgcgccgcg ccggggccgc cgccgccgcc gccgccgccg 60 ggccaggccc cgcgctggag ccgctggcgg gtccctgggc ggctgctgct gctgctgctg 120 cccgcgctct gctgcctccc gggcgccgcg cgggcggcgg cggcggcggc gggggcaggg 180 aaccgggcag cggtggcggt ggcggtggcg cgggcggacg aggcggaggc gcccttcgcc 240 gggcagaact ggttaaagtc ctatggctat ctgcttccct atgactcacg ggcatctgcg 300 ctgcactcag cgaaggcctt gcagtcggca gtctccacta tgcagcagtt ttacgggatc 360 ccggtcaccg gtgtgttgga tcagacaacg atcgagtgga tgaagaaacc ccgatgtggt 420 gtccctgatc acccccactt aagccgtagg cggagaaaca agcgctatgc cctgactgga 480 cagaagtgga ggcaaaaaca catcacctac agcattcaca actatacccc aaaagtgggt 540 gagctagaca cgcggaaagc tattcgccag gctttcgatg tgtggcagaa ggtgacccca 600 ctgacctttg aagaggtgcc ataccatgag atcaaaagtg accggaagga ggcagacatc 660 atgatctttt ttgcttctgg tttccatggc gacagctccc catttgatgg agaaggggga 720 ttcctggccc atgcctactt ccctggccca gggattggag gagacaccca ctttgactcc 780 gatgagccat ggacgctagg aaacgccaac catgacggga acgacctctt cctggtggct 840 gtgcatgagc tgggccacgc gctgggactg gagcactcca gcgaccccag cgccatcatg 900 gcgcccttct accagtacat ggagacgcac aacttcaagc tgccccagga cgatctccag 960 ggcatccaga agatctatgg acccccagcc gagcctctgg agcccacaag gccactccct 1020 acactccccg tccgcaggat ccactcacca teggagagga aacacgagcg ccagcccagg 1080 ccccctcggc cgcccctcgg ggaccggcca tccacaccag gcaccaaacc caacatctgt 1140 gacggcaact tcaacacagt ggccctcttc cggggcgaga tgtttgtctt taaggatcgc 1200 tggttctggc gtctgcgcaa taaccgagtg caggagggct accccatgca gatcgagcag 1260 ttctggaagg gcctgcctgc ccgcatcgac gcagcctatg aaagggccga tgggagattt 1320 gtcttcttca aaggtgacaa gtattgggtg tttaaggagg tgacggtgga gcctgggtac 1380 ccccacagcc tgggggagct gggcagctgt ttgccccgtg aaggcattga cacagctctg 1440 cgctgggaac ctgtgggcaa gacctacttt ttcaaaggcg agcggtactg gcgctacagc 1500 gaggagcggc gggccacgga ccctggctac cctaagccca tcaccgtgtg gaagggcatc 1560 ccacaggctc cccaaggagc cttcatcagc aaggaaggat attacaccta tttctacaag 1620 ggccgggact actggaagtt tgacaaccag aaactgagcg tggagccagg ctacccgcgc 1680 aacatcctgc gtgactggat gggctgcaac cagaaggagg tggagcggcg gaaggagcgg 1740 cggctgcccc aggacgacgt ggacatcatg gtgaccatca acgatgtgcc gggctccgtg 1800 aacgccgtgg ccgtggtcat cccctgcatc ctgtccctct gcatcctggt gctggtctac 1860 accatcttcc agttcaagaa caagacaggc cctcagcctg tcacctacta taagcggcca 1920 gtccaggaat gggtgtga 1938 77 1689 DNA Homo sapiens MT6MMP AJ27137 77 atgcggctgc ggctccggct gccccgaagc cctcggcgca tacctgccgc caccccaccc tctggcgctg ctgcttctgc tgctggcacc gcccgcgcgc 60 ggacgtgagc ctgggcgtgg actggctgac tcgctatggt 120 tgcccaggcc cagctgcaga gccctgagaa gttgcgcgat 180 gccatcaaag tcatgcagag gttcgcgggg ctgccggaga ccggccgcat ggacccaggg 240 acagtggcca ccatgcgtaa gccccgctgc tccctgcctg acgtgctggg ggtggcgggg 300 ctggtcaggc ggcgtcgccg gtacgctctg agcggcagcg tgtggaagaa gcgaaccctg 360 acatggaggg tacgttcctt cccccagagc tcccagctga gccaggagac cgtgcgggtc 420 ctcatgagct atgccctgat ggcctggggc atggagtcag gcctcacatt tcatgaggtg 480 gattcccccc agggccagga gcccgacatc ctcatcgact ttgcccgcgc cttccaccag 540 gacagctacc ccttcgacgg gttggggggc accctagccc atgccttctt ccctggggag 600 caccccatct ccggggacac tcactttgac gatgaggaga cctggacttt tgggtcaaaa 660 gacggcgagg ggaccgacct gtttgccgtg gctgtccatg agtttggcca cgccctgggc 720 ctgggccact cctcagcccc caactccatt atgaggccct tctaccaggg tccggtgggc 780 gaccctgaca agtaccgcct gtctcaggat gaccgcgatg gcctgcagca actctatggg 840 aaggcgcccc aaaccccata tgacaagccc acaaggaaac ccctggctcc tccgccccag 900 cccccggcct cgcccacaca cagcccatcc ttccccatcc ctgatcgatg tgagggcaat 960 tttgacgcca tcgccaacat ccgaggggaa actttcttct tcaaaggccc ctggttctgg 1020 cgcctccagc cctccggaca gctggtgtcc ccgcgacccg cacggctgca ccgcttctgg 1080 gaggggctgc ccgcccaggt gagggtggtg caggccgcct atgctcggca ccgagacggc 1140 cgaatcctcc tctttagcgg gccccagttc tgggtgttcc aggaccggca gctggagggc 1200 ggggcgcggc cgctcacgga gctggggctg cccccgggag aggaggtgga cgccgtgttc 1260 tcgtggccac agaacgggaa gacctacctg gtccgcggcc ggcagtactg gcgctacgac 1320 gaggcggcgg cgcgcccgga ccccggctac cctcgcgacc tgagcctctg ggaaggcgcg 1380 cccccctccc ctgacgatgt caccgtcagc aacgcaggtg acacctactt cttcaagggc 1440 gcccactact ggcgcttccc caagaacagc atcaagaccg agccggacgc cccccagccc 1500 atggggccca actggctgga ctgccccgcc ccgagctctg gtccccgcgc ccccaggccc 1560 cccaaagcga cccccgtgtc cgaaacctgc gattgtcagt gcgagctcaa ccaggccgca 1620 ggacgttggc ctgctcccat cccgctgctc ctcttgcccc tgctggtggg gggtgtagcc 1680 tcccgctga 1689 78 1749 DNA Homo sapiens MTMMP X90925 78 atgtctcccg ccccaagacc ctcccgttgt gcgctcgcct ccctcggctc ggcccaaagc caatatggct acctgcctcc cggggaccta ctctcagcgg ccatcgctgc catgcagaag gatgcagaca ccatgaaggc catgaggcgc gctgagatca aggccaatgt tcgaaggaag cataatgaaa tcactttctg catccagaat tacgaggcca ttcgcaaggc gttccgcgtg gaggtgccct atgcctacat ccgtgagggc tttgccgagg gcttccatgg cgacagcacg catgcctact tcccaggccc caacattgga tggactgtca ggaatgagga tctgaatgga ctgggccatg ccctggggct cgagcattcc taccagtgga tggacacgga gaattttgtg caactttatg ggggtgagtc agggttcccc tcccggcctt ctgttcctga taaacccaaa gggaactttg acaccgtggc catgctccga ttctggcggg tgaggaataa ccaagtgatg tggcggggcc tgcctgcgtc catcaacact ttcttcaaag gagacaagca ttgggtgttt aagcacatta aggagctggg ccgagggctg tggatgccca atggaaagac ctacttcttc gagctcaggg cagtggatag cgagtacccc gagtctccca gagggtcatt catgggcagc aacaaatact ggaaattcaa caaccagaag ctcctgctcc ccctgctcac gctcggcacc 60 agcagcttca gccccgaagc ctggctacag 120 cgtacccaca cacagcgctc accccagtca 180 ttttacggct tgcaagtaac aggcaaagct 240 ccccgatgtg gtgttccaga caagtttggg 300 cgctacgcca tccagggtct caaatggcaa 360 tacaccccca aggtgggcga gtatgccaca 420 tgggagagtg ccacaccact gcgcttccgc 480 catgagaagc aggccgacat catgatcttc 540 cccttcgatg gtgagggcgg cttcctggcc 600 ggagacaccc actttgactc tgccgagcct 660 aatgacatct tcctggtggc tgtgcacgag 720 agtgacccct cggccatcat ggcacccttt 780 ctgcccgatg atgaccgccg gggcatccag 840 accaagatgc cccctcaacc caggactacc 900 aaccccacct atgggcccaa catctgtgac 960 ggggagatgt ttgtcttcaa ggagcgctgg 1020 gatggatacc caatgcccat tggccagttc 1080 gcctacgaga ggaaggatgg caaattcgtc 1140 gatgaggcgt ccctggaacc tggctacccc 1200 cctaccgaca agattgatgc tgctctcttc 1260 cgtggaaaca agtactaccg tttcaacgaa 1320 aagaacatca aagtctggga agggatccct 1380 gatgaagtct tcacttactt ctacaagggg 1440 ctgaaggtag aaccgggcta ccccaagcca 1500 gccctgaggg actggatggg gagacggagg tgatcatcat gccgtggtgc tgcccgtgct ttcttcagac gccatgggac aaggtctga 79 744 DNA Homo sapiens FGF1 XM003647 ctgcccatcg ggaggccggc cggatgaggg gactgaggag 1560 tgaggtggac gaggagggcg gcggggcggt gagcgcggct 1620 gctgctgctc ctggtgctgg cggtgggcct tgcagtcttc 1680 ccccaggcga ctgctctact gccagcgttc cctgctggac 1740 1749 79 atggccgcgg ccatcgctag cggcttgatc cgccagaagc ggcaggcgcg ggagcagcac 60 tgggaccggc cgtctgccag caggaggcgg agcagcccca gcaagaaccg cgggctctgc 120 aacggcaacc tggtggatat cttctccaaa gtgcgcatct tcggcctcaa gaagcgcagg 180 ttgcggcgcc aagatcccca gctcaagggt atagtgacca ggttatattg caggcaaggc 240 tactacttgc aaatgcaccc cgatggagct ctcgatggaa ccaaggatga cagcactaat 300 tctacactct tcaacctcat accagtggga ctacgtgttg ttgccatcca gggagtgaaa 360 acagggttgt atatagccat gaatggagaa ggttacctct acccatcaga actttttacc 420 cctgaatgca agtttaaaga atctgttttt gaaaattatt atgtaatcta ctcatccatg 480 ttgtacagac aacaggaatc tggtagagcc tggtttttgg gattaaataa ggaagggcaa 540 gctatgaaag ggaacagagt aaagaaaacc aaaccagcag ctcattttct acccaagcca 600 ttggaagttg ccatgtaccg agaaccatct ttgcatgatg ttggggaaac ggtcccgaag 660 cctggggtga cgccaagtaa aagcacaagt gcgtctgcaa taatgaatgg aggcaaacca 720 gtcaacaaga gtaagacaac atag 744 80 468 DNA Homo sapiens FGF2 NM002006 80 atggcagccg ggagcatcac cacgctgccc gccttgcccg aggatggegg cagcggcgcc 60 ttcccgcccg gccacttcaa ggaccccaag eggctgtact geaaaaaegg gggcttcttc 120 ctgcgcatcc accccgacgg ccgagttgac ggggtccggg agaagagcga ccctcacatc 180 aagctacaac ttcaagcaga agagagagga gttgtgtcta tcaaaggagt gtgtgctaac 240 cgttacctgg ctatgaagga agatggaaga ttactggctt ctaaatgtgt tacggatgag 300 tgtttctttt ttgaacgatt ggaatctaat aactacaata cttaccggtc aaggaaatac 360 accagttggt atgtggcact gaaacgaact gggcagtata aacttggatc caaaacagga 420 cctgggcaga aagctatact ttttcttcca atgtctgcta agagctga 468 81 756 DNA Home > sapiens FGF23 NM020638 81 atgttggggg cccgcctcag gctctgggtc tgtgccttgt geagegtctg cagcatgagc 60 gtcctcagag cctatcccaa tgcctcccca ctgctcggct ccagctgggg tggectgate 120 cacctgtaca cagccacagc caggaacagc taccacctgc agatccacaa gaatggccat 180 gtggatggcg caccccatca gaccatctac agtgccctga tgatcagatc agaggatget 240 ggctttgtgg tgattacagg tgtgatgagc aacatttttg gatcacacta tttcgacccg gaaaacgggt acgacgtcta ccactctcct gcgaagagag ccttcctgcc aggcatgaac aggaacgaga tccccctaat tcacttcaac gccgaggacg actcggagcg ggaccccctg ccggccccgg cctcctgttc acaggagctc agtgacccat taggggtggt caggggcggt ccggaaggct gccgcccctt cgccaagttc agaagatacc tctgcatgga tttcagaggc 300 gagaactgca ggttccaaca ccagacgctg 360 cagtatcact tcctggtcag tctgggccgg 420 ccacccccgt actcccagtt cctgtcccgg 480 acccccatac cacggcggca cacccggagc 540 aacgtgctga agccccgggc ccggatgacc 600 ccgagcgccg aggacaacag cccgatggcc 660 cgagtgaaca cgcacgctgg gggaacgggc 720 atctag 756 82 720 DNA Homo sapiens FGF3 NM005247 82 atgggcctaa tctggctgct actgctcagc cctggggcgc ggttgcggcg cgatgcgggc ggggcgcccc ggcgccgcaa gctctactgc agcggccgcg tcaacggcag cctggagaac gtggaggtgg gcattgtggc catcaggggt aagaggggac gactctatgc ttcggagcac atccacgagc tgggctataa tacgtatgcc cctggggccc gccggcagcc cagcgccgag ggccggcccc gcaggggctt caagacccgc cgcgtgctgg accacaggga ccacgagatg ccccctggta agggggtcca gccccgacgg ctgctggagc ccggctggcc cgcagcgggc 60 ggccgtggcg gcgtctacga gcaccttggc 120 gccacgaagt accacctcca gctgcacccg 180 agcgcctaca gtattttgga gataacggca 240 ctcttctccg ggcggtacct ggccatgaac 300 tacagcgccg agtgcgagtt tgtggagcgg 360 tcccggctgt accggacggt gtctagtacg 420 agactgtggt acgtgtctgt gaacggcaag 480 cgcacacaga agtcctccct gttcctgccc 540 gtgcggcagc tacagagtgg gctgcccaga 600 cggcggcaga agcagagccc ggataacctg 660 gagccctctc acgttcaggc ttcgagactg 83 807 DNA Homo sapiens FGF5 NM004464 ggctcccagc tggaggccag tgcgcactag 720 83 atgagcttgt ccttcctcct cctcctcttc cacggggaga agcgtctcgc ccccaaaggg cctataggct ccagcagcag acagagcagc tcctcccccg cagcttctct gggcagccaa tggagcccct cggggcgccg gaccggcagc ctgcagatct acccggatgg caaagtcaat ttggaaatat ttgctgtgtc tcaggggatt tttttagcga tgtcaaaaaa aggaaaactc aagttcaggg agcgttttca agaaaatagc actgaaaaaa cagggcggga gtggtatgtt gggtgcagcc cccgggttaa accccagcat cagtcggagc agccagaact ttctttcacg agccctatca agtcaaagat tcccctttct tacagactca agtttcgctt tggataa ttcagccacc tgatcctcag cgcctgggct 60 caacccggac ccgctgccac tgataggaac 120 agtagcgcta tgtcttcctc ttctgcctcc 180 ggaagtggct tggagcagag cagtttccag 240 ctctactgca gagtgggcat cggtttccat 300 ggatcccacg aagccaatat gttaagtgtt 360 gtaggaatac gaggagtttt cagcaacaaa 420 catgcaagtg ccaagttcac agatgactgc 480 tataatacct atgcctcagc aatacataga 540 gccctgaata aaagaggaaa agccaaacga 600 atctctaccc attttcttcc aagattcaag 660 gttactgttc ctgaaaagaa aaatccacct 720 gcacctcgga aaaataccaa ctcagtgaaa 780 807 84 649 DNA Homo sapiens FGF8 NM006119 84 atgggcagcc cccgctccgc gctgagctgc ctgctgttgc acttgctggt caagcccagg taactgttca gtcctcacct aattttacac agcatgtgag ctggtgacgg atcagctcag ccgccgcctc atccggacct accaactcta agcgggaagc acgtgcaggt cctggccaac aagcgcatca acgccatggc gaccccttcg caaagctcat cgtggagacg gacacctttg gaagcagagt ggagccgaga cgggcctcta catctgcatg aacaagaagg ggaagctgat aacggcaaag gcaaggactg cgtcttcacg gagattgtgc tggagaacaa ctgcagaatg ccaagtacga gggctggtac atggccttca cccgcaaggg aagggctcca agacgcggca gcaccagcgt gaggtccact tcatgaagcg ggccaccaca ccaccgagca gagcctgcgc ttcgagttcc tcaactaccc cgcagcctgc gcggcagcca gaggacttgg gccccggaac cccgatagg 85 2466 DNA Homo sapiens cctctgcctc 60 ggagcagagc 120 cagccgcacc 180 agaggacggc 240 tcgagtccga 300 cgccaagagc 360 ctacacagcg 420 ccggccccgc 480 gctgccccgg 540 gcccttcacg 600 649 FGFR2 NM000141 85 atggtcagct ggggtcgttt catctgcctg gtcgtggtca ccatggcaac cttgtccctg 60 gcccggccct ccttcagttt agttgaggat accacattag agccagaaga gccaccaacc 120 aaataccaaa tctctcaacc agaagtgtac gtggctgcgc caggggagtc gctagaggtg 180 cgctgcctgt tgaaagatgc cgccgtgatc agttggacta aggatggggt gcacttgggg 240 cccaacaata ggacagtgct tattggggag tacttgcaga taaagggcgc cacgcctaga 300 gactccggcc tctatgcttg tactgccagt aggactgtag acagtgaaac ttggtacttc 360 atggtgaatg tcacagatgc catctcatcc ggagatgatg aggatgacac cgatggtgcg 420 gaagattttg tcagtgagaa cagtaacaac aagagagcac catactggac caacacagaa 480 aagatggaaa agcggctcca tgctgtgcct gcggccaaca ctgtcaagtt tcgctgccca 540 gccgggggga acccaatgcc aaccatgcgg tggctgaaaa acgggaagga gtttaagcag 600 gagcatcgca ttggaggcta caaggtacga aaccagcact ggagcctcat tatggaaagt 660 gtggtcccat ctgacaaggg aaattatacc tgtgtggtgg agaatgaata cgggtccatc 720 aatcacacgt accacctgga tgttgtggag cgatcgcctc accggcccat cctccaagcc 780 ggactgccgg caaatgcctc cacagtggtc ggaggagacg tagagtttgt ctgcaaggtt 840 tacagtgatg cccagcccca catccagtgg atcaagcacg tggaaaagaa cggcagtaaa 900 tacgggcccg acgggctgcc ctacctcaag gttctcaagg ccgccggtgt taacaccacg 960 gacaaagaga ttgaggttct ctatattcgg aatgtaactt ttgaggacgc tggggaatat 1020 acgtgcttgg cgggtaattc tattgggata tcctttcact ctgcatggtt gacagttctg 1080 ccagcgcctg gaagagaaaa ggagattaca gcttccccag actacctgga gatagccatt 1140 tactgcatag gggtcttctt aatcgcctgt atggtggtaa cagtcatcct gtgccgaatg 1200 aagaacacga ccaagaagcc agacttcagc agccagccgg ctgtgcacaa gctgaccaaa 1260 cgtatccccc tgcggagaca ggtaacagtt tcggctgagt ccagctcctc catgaactcc 1320 aacaccccgc tggtgaggat aacaacacgc ctctcttcaa cggcagacac ccccatgctg 1380 gcaggggtct ccgagtatga acttccagag gacccaaaat gggagtttcc aagagataag 1440 ctgacactgg gcaagcccct gggagaaggt tgctttgggc aagtggtcat ggcggaagca 1500 gtgggaattg acaaagacaa gcccaaggag gcggtcaccg tggccgtgaa gatgttgaaa 1560 gatgatgcca cagagaaaga cctttctgat ctggtgtcag agatggagat gatgaagatg 1620 attgggaaac acaagaatat cataaatctt cttggagcct gcacacagga tgggcctctc 1680 tatgtcatag ttgagtatgc ctctaaaggc aacctccgag aatacctccg agcccggagg 1740 ccacccggga tggagtactc ctatgacatt aaccgtgttc ctgaggagca gatgaccttc 1800 aaggacttgg tgtcatgcac ctaccagctg gccagaggca tggagtactt ggcttcccaa 1860 aaatgtattc atcgagattt agcagccaga aatgttttgg taacagaaaa caatgtgatg 1920 aaaatagcag actttggact cgccagagat atcaacaata tagactatta caaaaagacc 1980 accaatgggc ggcttccagt caagtggatg gctccagaag ccctgtttga tagagtatac 2040 actcatcaga gtgatgtctg gtccttcggg gtgttaatgt gggagatctt cactttaggg 2100 ggctcgccct acccagggat tcccgtggag agaatggata agccagccaa ctgcaccaac catgcagtgc cctcccagag accaacgttc ctcactctca caaccaatga ggaatacttg cctagttacc ctgacacaag aagttcttgt gaccccatgc cttacgaacc atgccttcct acatga 86 2421 DNA Homo sapiens FGFR3 NM000142 gaacttttta agctgctgaa ggaaggacac 2160 gaactgtaca tgatgatgag ggactgttgg 2220 aagcagttgg tagaagactt ggatcgaatt 2280 gacctcagcc aacctctcga acagtattca 2340 tcttcaggag atgattctgt tttttctcca 2400 cagtatccac acataaacgg cagtgttaaa 2460 2466 86 atgggcgccc ctgcctgcgc cctcgcgctc tcctcggagt ccttggggac ggagcagcgc ccagagcccg gccagcagga gcagttggtc tgtcccccgc ccgggggtgg tcccatgggg ctggtgccct cggagcgtgt cctggtgggg cacgaggact ccggggccta cagctgccgg ttcagtgtge gggtgacaga cgctccatcc gctgaggaca caggtgtgga cacaggggcc aagaagctgc tggccgtgcc ggccgccaac aaccccactc cctccatctc ctggctgaag attggaggca tcaagctgcg gcatcagcag tcggaccgcg gcaactacac ctgcgtcgtg tacacgctgg acgtgctgga gcgctccccg tgcgtggccg tggccatcgt ggccggcgcc 60 gtegtggggc gagcggcaga agtcccgggc 120 ttcggcagcg gggatgctgt ggagctgagc 180 cccactgtct gggtcaagga tggcacaggg 240 ccccagcggc tgcaggtgct gaatgcctcc 300 cagcggctca cgcagcgcgt actgtgccac 360 tcgggagatg acgaagacgg ggaggacgag 420 ccttactgga cacggcccga gcggatggac 480 accgtccgct tccgctgccc agccgctggc 540 aacggcaggg agttccgcgg cgagcaccgc 600 tggagcctgg tcatggaaag cgtggtgccc 660 gagaacaagt ttggcagcat ccggcagacg 720 caccggccca tcctgcaggc ggggctgccg 780 gccaaccaga cggcggtgct gggcagcgac gtggagttcc actgcaaggt gtacagtgac 840 gcacagcccc acatccagtg gctcaagcac gtggaggtga acggcagcaa ggtgggcccg 900 gacggcacac cctacgttac cgtgctcaag acggcgggcg ctaacaccac cgacaaggag 960 ctagaggttc tctccttgca caacgtcacc tttgaggacg ccggggagta cacctgcctg 1020 gcgggcaatt ctattgggtt ttctcatcac tctgcgtggc tggtggtgct gccagccgag 1080 gaggagctgg tggaggctga cgaggcgggc agtgtgtatg caggcatcct cagctacggg 1140 gtgggcttct tcctgttcat cctggtggtg gcggctgtga cgctctgccg cctgcgcagc 1200 ccccccaaga aaggcctggg ctcccccacc gtgcacaaga tctcccgctt cccgctcaag 1260 cgacaggtgt ccctggagtc caacgcgtcc atgagctcca acacaccact ggtgcgcatc 1320 gcaaggctgt cctcagggga gggccccacg ctggccaatg tctccgagct cgagctgcct 1380 gccgacccca aatgggagct gtctcgggcc cggctgaccc tgggcaagcc ccttggggag 1440 ggctgcttcg gccaggtggt catggcggag gccatcggca ttgacaagga ccgggccgcc 1500 aagcctgtca ccgtagccgt gaagatgctg aaagacgatg ccactgacaa ggacctgtcg 1560 gacctggtgt ctgagatgga gatgatgaag atgatcggga aacacaaaaa catcatcaac 1620 ctgctgggcg cctgcacgca gggcgggccc ctgtacgtgc tggtggagta cgcggccaag 1680 ggtaacctgc gggagtttct gcgggcgcgg cggcccccgg gcctggacta ctccttcgac 1740 acctgcaagc cgcccgagga gcagctcacc ttcaaggacc tggtgtcctg tgcctaccag 1800 gtggcccggg gcatggagta cttggcctcc cagaagtgca tccacaggga cctggctgcc 1860 cgcaatgtgc tggtgaccga ggacaacgtg atgaagatcg cagacttcgg gctggcccgg 1920 gacgtgcaca acctcgacta ctacaagaag acaaccaacg gccggctgcc cgtgaagtgg 1980 atggcgcctg aggccttgtt tgaccgagtc tacactcacc agagtgacgt ctggtccttt 2040 ggggtcctgc tctgggagat cttcacgctg gggggctccc cgtaccccgg catccctgtg 2100 gaggagctct tcaagctgct gaaggagggc caccgcatgg acaagcccgc caactgcaca 2160 cacgacctgt acatgatcat gcgggagtgc tggcatgccg cgccctccca gaggcccacc 2220 ttcaagcagc tggtggagga cctggaccgt gtccttaccg tgacgtccac cgacgagtac 2280 ctggacctgt cggcgccttt cgagcagtac tccccgggtg gccaggacac ccccagctcc 2340 agctcctcag gggacgactc cgtgtttgcc cacgacctgc tgcccccggc cccacccagc 2400 agtgggggct cgcggacgtg a 2421 87 2102 DNA Homo sapiens HGF E08541 87 atgcagaggg acaaaggaaa agaagaaata caattcatga attcaaaaaa tcagcaaaga 60 ctaccctaat caaaatagat ccagcactga agataaaaac caaaaaagtg aatactgcag 120 accaatgtgc taatagatgt actaggaata aaggacttcc attcacttgc aaggcttttg 180 tttttgataa agcaagaaaa caatgcctct ggttcccctt caatagcatg tcaagtggag 240 tgaaaaaaga atttggccat gaatttgacc tctatgaaaa caaagactac attagaaact 300 gcatcattgg taaaggacgc agctacaagg gaacagtatc tatcactaag agtggcatca 360 aatgtcagcc ctggagttcc atgataccac acgaacacag ctttttgcct tcgagctatc 420 ggggtaaaga cctacaggaa aactactgtc gaaatcctcg aggggaagaa gggggaccct 480 ggtgtttcac aagcaatcca gaggtacgct acgaagtctg tgacattcct cagtgttcag 540 aagttgaatg catgacctgc aatggggaga gttatcgagg tctcatggat catacagaat 600 caggcaagat ttgtcagcgc tgggatcatc agacaccaca ccggcacaaa ttcttgcctg 660 aaagatatcc cgacaagggc tttgatgata attattgccg caatcccgat ggccagccga 720 ggccatggtg ctatactctt gaccctcaca cccgctggga gtactgtgca attaaaacat 780 gcgctgacaa tactatgaat gacactgatg ttcctttgga aacaactgaa tgcatccaag 840 gtcaaggaga aggctacagg ggcactgtca ataccatttg gaatggaatt ccatgtcagc 900 gttgggattc tcagtatcct cacgagcatg acatgactcc tgaaaatttc aagtgcaagg 960 acctacgaga aaattactgc cgaaatccag atgggtctga atcaccctgg tgttttacca 1020 ctgatccaaa catccgagtt ggctactgct cccaaattcc aaactgtgat atgtcacatg 1080 gacaagattg ttatcgtggg aatggcaaaa attatatggg caacttatcc caaacaagat 1140 ctggactaac atgttcaatg tgggacaaga acatggaaga cttacatcgt catatcttct 1200 gggaaccaga tgcaagtaag ctgaatgaga attactgccg aaatccagat gatgatgctc 1260 atggaccctg gtgctacacg ggaaatccac tcattccttg ggattattgc cctatttctc 1320 gttgtgaagg tgataccaca cctacaatag tcaatttaga ccatcccgta atatcttgtg 1380 ccaaaaggaa acaattgcga gttgtaaatg ggattccaac acgaacaaac ataggatgga 144U tggttagttt gagatacaga aataaacata tctgcggagg atcattgata aaggagagtt 1500 gggttcttac tgcacgacag tgtttccctt ctcgagactt gaaagattat gaagcttggc 1560 ttggaattca tgatgtccac ggaagaggag atgagaaatg caaacaggtt ctcaatgttt 1620 cccagctggt atatggccct gaaggatcag atctggtttt aatgaagctt gccaggcctg 1680 ctgtcctgga tgattttgtt agtacgattg atttacctaa ttatggatgc acaattcctg 1740 aaaagaccag ttgcagtgtt tatggctggg gctacactgg attgatcaac tatgatggcc 1800 tattacgagt ggcacatctc tatataatgg gaaatgagaa atgcagccag catcatcgag 1860 ggaaggtgac tctgaatgag tctgaaatat gtgctggggc tgaaaagatt ggatcaggac 1920 catgtgaggg ggattatggt ggcccacttg tttgtgagca acataaaatg agaatggttc 1980 ttggtgtcat tgttcctggt cgtggatgtg ccattccaaa tcgtcctggt atttttgtcc 2040 gagtagcata ttatgcaaaa tggatacaca aaattatttt aacatataag gtaccacagt 2100 ca 2102 88 360 DNA Homo sapiens ID3 XM001539 88 atgaaggcgc tgagcccggt gcgcggctgc tacgaggcgg tgtgctgcct gtcggaacgc 60 agtctggcca tcgcccgggg ccgagggaag ggcccggcag ctgaggagcc gctgagcttg 120 ctggacgaca tgaaccactg ctactcccgc ctgcgggaac tggtacccgg agtcccgaga 180 ggcactcagc ttagccaggt ggaaatccta cagcgcgtca tcgactacat tctcgacctg 240 caggtagtcc tggccgagcc agcccctgga ccccctgatg gcccccacct tcccatccag 300 acagccgagc tcactccgga acttgtcatc tccaacgaca aaaggagctt ttgccactga 360 89 743 DNA Homo sapiens IGF2 NM000612 89 atgggaatcc caatggggaa gtcgatgctg tgctgcattg ctgcttaccg ccccagtgag ctccagttcg tctgtgggga ccgcggcttc cgtcgcagcc gtggcatcgt tgaggagtgc gagacgtact gtgctacccc cgccaagtcc cttccggaca acttccccag ataccccgtg cagtccaccc agcgcctgcg caggggcctg gtgctcgcca aggagctcga ggcgttcagg ctacccaccc aagaccccgc ccacgggggc tgagcaaaac tgccgcaagt ctgcagcccg acggacgttt ccatcaggtt ccatcccgaa tctcctgacc cagtccccgt gccccgcctc ccatcgggct gaggaagcac age gtgettctea ccttcttggc cttcgcctcg 60 accctgtgcg geggggaget ggtggacacc 120 tacttcagca ggcccgcaag ccgtgtgagc 180 tgtttccgca gctgtgacct ggccctcctg 240 gagagggacg tgtcgacccc tccgaccgtg 300 ggcaagttct tccaatatga cacctggaag 360 cctgccctcc tgcgtgcccg ccggggtcac 420 gaggecaaac gtcaccgtcc ectgattget 480 gcccccccag agatggccag caateggaag 540 gcgccaccat cctgcagcct cctcctgacc 600 aatctctegg ttccacgtcc ccctggggct 660 cccgaaacag gctactctcc tcggccccct 720 743 90 7476 DNA Homo sapiens IGF2R NM000876 90 atgggggccg ccgccggccg gagcccccac ctggggcccg cgcccgcccg ccgcccgcag 60 cgctctctgc tcctgctgca gctgctgctg ctcgtcgctg ccccggggtc cacgcaggcc 120 caggccgccc cgttccccga gctgtgcagt tatacatggg aagctgttga taccaaaaat 180 aatgtacttt ataaaatcaa catctgtgga agtgtggata ttgtccagtg cgggccatca 240 agtgctgttt gtatgcacga cttgaagaca cgcacttatc attcagtggg tgactctgtt 300 ttgagaagtg caaccagatc tctcctggaa ttcaacacaa cagtgagctg tgaccagcaa 360 ggcacaaatc acagagtcca gagcagcatt gccttcctgt gtgggaaaac cctgggaact 420 cctgaatttg taactgcaac agaatgtgtg cactactttg agtggaggac cactgcagcc 480 tgcaagaaag acatatttaa agcaaataag gaggtgccat gctatgtgtt tgatgaagag 540 ttgaggaagc atgatctcaa tcctctgatc aagcttagtg gtgcctactt ggtggatgac 600 tccgatccgg acacttctct attcatcaat gtttgtagag acatagacac actacgagac 660 ccaggttcac agctgcgggc ctgtcccccc ggcactgccg cctgcctggt aagaggacac 720 caggcgtttg atgttggcca gccccgggac ggactgaagc tggtgcgcaa ggacaggctt 780 gtcctgagtt acgtgaggga agaggcagga aagctagact tttgtgatgg tcacagccct 840 gcggtgacta ttacatttgt ttgcccgtcg gagcggagag agggcaccat tcccaaactc 900 acagctaaat ccaactgccg ctatgaaatt gagtggatta ctgagtatgc ctgccacaga 960 gattacctgg aaagtaaaac ttgttctctg agcggcgagc agcaggatgt ctccatagac 1020 ctcacaccac ttgcccagag cggaggttca tcctatattt cagatggaaa agaatatttg 1080 ttttatttga atgtctgtgg agaaactgaa atacagttct gtaataaaaa acaagctgca 1140 gtttgccaag tgaaaaagag cgatacctct caagtcaaag cagcaggaag ataccacaat 1200 cagaccctcc gatattcgga tggagacctc accttgatat attttggagg tgatgaatgc 1260 agctcagggt ttcagcggat gagcgtcata aactttgagt gcaataaaac cgcaggtaac 1320 gatgggaaag gaactcctgt attcacaggg gaggttgact gcacctactt cttcacatgg 1380 gacacggaat acgcctgtgt taaggagaag gaagacctcc tctgcggtgc caccgacggg 1440 aagaagcgct atgacctgtc cgcgctggtc cgccatgcag aaccagagca gaattgggaa 1500 gctgtggatg gcagtcagac ggaaacagag aagaagcatt ttttcattaa tatttgtcac 1560 agagtgctgc aggaaggcaa ggcacgaggg tgtcccgagg acgcggcagt gtgtgcagtg 1620 gataaaaatg gaagtaaaaa tctgggaaaa tttatttcct ctcccatgaa agagaaagga 1680 aacattcaac tctcttattc agatggtgat gattgtggtc atggcaagaa aattaaaact 1740 aatatcacac ttgtatgcaa gccaggtgat ggggaaggcg gttgctttta tgagtttgag aagacagaag gggagaactg cacggtcttt tcacctctca caaagaaaaa tggtgcctat ataaatgtgt gtggcccggt gtctgtgagc gtggcaaaaa gtgatgagaa gacttggaac tatgatggga tgatccaact gaactacaga acaccgagag ctacgctcat cacctttctc gaatatcagg aagaggataa ctccacctac ccggaggagc ccctggaatg cgtagtgacc tccagtctgg caaaatctga aggtggcctt ggggaacatg tcacgtggag gaaatactac ccgggctgca accgatatgc atcggcttgc ttcactgaag tggtttccat cagtaacttg gacagcggca gcctccttct ggaatacgtg agacagacca catataccac gaggatccat caccccatct tttctctcaa ctgggagtgt gcctgtccca ttcagacaac gacggataca agtggatttg tgtttaatct taatccgcta attgggaaga tttttatgtt taatgtctgc ggaaaacctg cttctggctg tgaggcagaa ccagcaaggc cagtcggaat tgagaaaagc ctgacctaca aagggcctct ctctgccaaa gtttgcaatg atgatgttta ctcagggccc gggcaaggga tccgaaacac ttactttgag ccagtggact gccaagtcac cgacctggct acagtcagga aaccttggac ggctgttgac tatttgagcg tttgcaatcc tctcccttac tcttgcttag tgtcagaagg caatagctgg gccgcggcga atggatcttt gagcatcatg cgcttctcca ccaggatcac gtttgagtgt ctggaaagtg caccagtgtt gagaacttct 1800 tggcgcacag ctgcggcctg tgtgctgtct 1860 gactcccagg cagggttttc ttttgactta 1920 aaagttgaga caaagaagta tgacttttat 1980 ccctgtcagc cagactcagg agcctgccag 2040 ttgggtctga gtaatgcgaa gctttcatat 2100 ggcggcacac cctataacaa tgaaagacac 2160 tgtgatcgag acgcgggagt gggcttccct 2220 aacttccggt ggtacaccag ctatgcctgc 2280 gacccctcca cgctggagca gtacgacctc 2340 ggaggaaact ggtatgccat ggacaactca 2400 attaacgtgt gtcggcctct gaatccagtg 2460 cagatgaagt atgaaaaaga tcagggctcc 2520 ggaatggcaa agaccggccc ggtggttgag 2580 aatgggtcgg cctgcaccac cagcgatggc 2640 ctcgtctgct ccaggggcag gctgaacagc 2700 gtggtcagtt tcctgtggaa cacagaggct 2760 gaccaggctt gctctataag ggatcccaac 2820 aacagttcgc aaggatataa cgtctctggc 2880 ggcacaatgc ctgtctgtgg gaccatcctg 2940 acccaaactg aagagctcaa gaattggaag 3000 ctccagctgt ccacagaggg cttcatcact 3060 ggtaccgctg atgcttttat cgtccgcttt 3120 ctcaaattcc tgcatcaaga tatcgactct 3180 tttgaaaccg cgttggcctg tgttccttct 3240 ggaaatgagt acgacctgac tggcctaagc 3300 acctctgtcg atgggagaaa gaggactttc 3360 attcctggat gccagggcag cgcagtgggg 3420 aatctgggtg tggtgcagat gagtccccaa 3480 tatgtcaacg gtgacaagtg tgggaaccag 3540 gctcagatat cgggctcacc agcatttcag 3600 cttcaggatg gttgtgagta cgtgtttatc tggagaactg tggaagcctg tcccgttgtc 3660 agagtggaag gggacaactg tgaggtgaaa gacccaaggc atggcaactt gtatgacctg 3720 aagcccctgg gcctcaacga caccatcgtg agcgctggcg aatacactta ttacttccgg 3780 gtctgtggga agctttcctc agacgtctgc cccacaagtg acaagtccaa ggtggtctcc 3840 tcatgtcagg aaaagcggga accgcaggga tttcacaaag tggcaggtct cctgactcag 3900 aagctaactt atgaaaatgg cttgttaaaa atgaacttca cgggggggga cacttgccat 3960 aaggtttatc agcgctccac agccatcttc ttctactgtg accgcggcac ccagcggcca 4020 gtatttctaa aggagacttc agattgttcc tacttgtttg agtggcgaac gcagtatgcc 4080 tgcccacctt tcgatctgac tgaatgttca ttcaaagatg gggctggcaa ctccttcgac 4140 ctctcgtccc tgtcaaggta cagtgacaac tgggaagcca tcactgggac gggggacccg 4200 gagcactacc tcatcaatgt ctgcaagtct ctggccccgc aggctggcac tgagccgtgc 4260 cctccagaag cagccgcgtg tctgctgggt ggctccaagc ccgtgaacct cggcagggta 4320 agggacggac ctcagtggag agatggcata attgtcctga aatacgttga tggcgactta 4380 tgtccagatg ggattcggaa aaagtcaacc accatccgat tcacctgcag cgagagccaa 4440 gtgaactcca ggcccatgtt catcagcgcc gtggaggact gtgagtacac ctttgcctgg 4500 cccacagcca cagcctgtcc catgaagagc aacgagcatg atgactgcca ggtcaccaac 4560 ccaagcacag gacacctgtt tgatctgagc tccttaagtg gcagggcggg attcacagct 4620 gcttacagcg agaaggggtt ggtttacatg agcatctgtg gggagaatga aaactgccct 4680 cctggcgtgg gggcctgctt tggacagacc aggattagcg tgggcaaggc caacaagagg 4740 ctgagatacg tggaccaggt cctgcagctg gtgtacaagg atgggtcccc ttgtccctcc 4800 aaatccggcc tgagctataa gagtgtgatc agtttcgtgt gcaggcctga ggccgggcca 4860 accaataggc ccatgctcat ctccctggac aagcagacat gcactctctt cttctcctgg 4920 cacacgccgc tggcctgcga gcaagcgacc gaatgttccg tgaggaatgg aagctctatt 4980 gttgacttgt ctccccttat tcatcgcact ggtggttatg aggcttatga tgagagtgag 5040 gatgatgcct ccgataccaa ccctgatttc tacatcaata tttgtcagcc actaaatccc 5100 atgcacgcag tgccctgtcc tgccggagcc gctgtgtgca aagttcctat tgatggtccc 5160 cccatagata tcggccgggt agcaggacca ccaatactca atccaatagc aaatgagatt 5220 tacttgaatt ttgaaagcag tactccttgc ttagcggaca agcatttcaa ctacacctcg 5280 ctcatcgcgt ttcactgtaa gagaggtgtg agcatgggaa cgcctaagct gttaaggacc 5340 agcgagtgcg actttgtgtt cgaatgggag actcctgtcg tctgtcctga tgaagtgagg 5400 atggatggct gtaccctgac agatgagcag ctcctctaca gcttcaactt gtccagcctt 5460 tccacgagca cctttaaggt gactcgcgac tcgcgcacct acagcgttgg ggtgtgcacc 5520 tttgcagtcg ggccagaaca aggaggctgt aaggacggag gagtctgtct gctctcaggc 5580 accaaggggg catcctttgg acggctgcaa tcaatgaaac tggattacag gcaccaggat 5640 gaagcggtcg ttttaagtta cgtgaatggt gatcgttgcc ctccagaaac cgatgacggc 5700 gtcccctgtg tcttcccctt catattcaat gggaagagct acgaggagtg catcatagag 5760 agcagggcga agctgtggtg tagcacaact gcggactacg acagagacca cgagtggggc 5820 ttctgcagac actcaaacag ctaccggaca tccagcatca tatttaagtg tgatgaagat 5880 gaggacattg ggaggccaca agtcttcagt gaagtgcgtg ggtgtgatgt gacatttgag 5940 tggaaaacaa aagttgtctg ccctccaaag aagttggagt gcaaattcgt ccagaaacac 6000 aaaacctacg acctgcggct gctctcctct ctcaccgggt cctggtccct ggtccacaac 6060 ggagtctcgt actatataaa tctgtgccag aaaatatata aagggcccct gggctgctct 6120 gaaagggcca gcatttgcag aaggaccaca actggtgacg tccaggtcct gggactcgtt 6180 cacacgcaga agctgggtgt cataggtgac aaagttgttg tcacgtactc caaaggttat 6240 ccgtgtggtg gaaataagac cgcatcctcc gtgatagaat tgacctgtac aaagacggtg 6300 ggcagacctg cattcaagag gtttgatatc gacagctgca cttactactt cagctgggac 6360 tcccgggctg cctgcgccgt gaagcctcag gaggtgcaga tggtgaatgg gaccatcacc 6420 aaccctataa atggcaagag cttcagcctc ggagatattt attttaagct gttcagagcc 6480 tctggggaca tgaggaccaa tggggacaac tacctgtatg agatccaact ttcctccatc 6540 acaagctcca gaaacccggc gtgctctgga gccaacatat gccaggtgaa gcccaacgat 6600 cagcacttca gtcggaaagt tggaacctct gacaagacca agtactacct tcaagacggc 6660 gatctcgatg tcgtgtttgc ctcttcctct aagtgcggaa aggataagac caagtctgtt 6720 tcttccacca tcttcttcca ctgtgaccct ctggtggagg acgggatccc cgagttcagt 6780 cacgagactg ccgactgcca gtacctcttc tcttggtaca cctcagccgt gtgtcctctg 6840 ggggtgggct ttgacagcga gaatcccggg gacgacgggc agatgcacaa ggggctgtca 6900 gaacggagcc aggcagtcgg cgcggtgcte agcctgctgc tggtggcgct cacctgctgc 6960 ctgctggccc tgttgctcta caagaaggag aggagggaaa cagtgataag taagctgacc 7020 acttgctgta ggagaagttc caacgtgtcc tacaaatact caaaggtgaa taaggaagaa 7080 gagacagatg agaatgaaac agagtggctg atggaagaga tccagctgcc tcctccacgg 7140 cagggaaagg aagggcagga gaacggccat attaccacca agtcagtgaa agccctcagc 7200 tccctgcatg gggatgacca ggacagtgag gatgaggttc tgaccatccc agaggtgaaa 7260 gttcactcgg gcaggggagc tggggcagag agctcccacc cagtgagaaa cgcacagagc 7320 aatgcccttc aggagcgtga ggacgatagg gtggggctgg tcaggggtga gaaggcgagg 7380 aaagggaagt ccagctctgc acagcagaag acagtgagct ccaccaagct ggtgtccttc 7440 catgacgaca gcgacgagga cctcttacac atctga 7476 91 4104 DNA Homo sapiens IGF1R NM000875 91 atgaagtctg gctccggagg agggtccccg acctcgctgt gggggctcct gtttctctcc 60 gccgcgctct cgctctggcc gacgagtgga gaaatctgcg ggccaggcat cgacatccgc 120 aacgactatc agcagctgaa gcgcctggag aactgcacgg tgatcgaggg ctacctccac 180 atcctgctca tctccaaggc cgaggactac cgcagctacc gcttccccaa gctcacggtc 240 attaccgagt acttgctgct gttccgagtg gctggcctcg agagcctcgg agacctcttc 300 cccaacctca cggtcatccg cggctggaaa ctcttctaca actacgccct ggtcatcttc 360 gagatgacca atctcaagga tattgggctt tacaacctga ggaacattac tcggggggcc 420 atcaggattg agaaaaatgc tgacctctgt tacctctcca ctgtggactg gtccctgatc 480 ctggatgcgg tgtccaataa ctacattgtg gggaataagc ccccaaagga atgtggggac 540 ctgtgtccag ggaccatgga ggagaagccg atgtgtgaga agaccaccat caacaatgag 600 tacaactacc gctgctggac cacaaaccgc tgccagaaaa tgtgcccaag cacgtgtggg 660 aagcgggcgt gcaccgagaa caatgagtgc tgccaccccg agtgcctggg cagctgcagc 720 gcgcctgaca acgacacggc ctgtgtagct tgccgccact actactatgc cggtgtctgt 780 gtgcctgcct gcccgcccaa cacctacagg tttgagggct ggcgctgtgt ggaccgtgac 840 ttctgcgcca acatcctcag cgccgagagc agcgactccg aggggtttgt gatccacgac 900 ggcgagtgca tgcaggagtg cccctcgggc ttcatccgca acggcagcca gagcatgtac 960 tgcatccctt gtgaaggtcc ttgcccgaag gtctgtgagg aagaaaagaa aacaaagacc 1020 attgattctg ttacttctgc tcagatgctc ctcattaaca tccgacgggg gaataacatt atcgaggtgg tgacgggcta cgtgaagatc ttcctaaaaa accttcgcct catcctagga tacgtcctcg acaaccagaa cttgcagcaa atcaaagcag ggaaaatgta ctttgctttc cgcatggagg aagtgacggg gactaaaggg aacaacgggg agagagcctc ctgtgaaagt tcgaagaatc gcatcatcat aacctggcac atcagcttca ccgtttacta caaggaagca caggatgcct gcggctccaa cagctggaac gacgtggagc ccggcatctt actacatggg gtcaaggctg tgaccctcac catggtggag atcttgtaca ttcgcaccaa tgcttcagtt tcgaactcct cttctcagtt aatcgtgaag ctgagttact acattgtgcg ctggcagcgg aattactgct ccaaagacaa aatccccatc gaggaggtca cagagaaccc caagactgag gcctgcccca aaactgaagc cgagaagcag gtctttgaga atttcctgca caactccatc gatgtcatgc aagtggccaa caccaccatg gacacctaca acatcaccga cccggaagag agagtggata acaaggagag aactgtcatt atcgatatcc acagctgcaa ccacgaggct gtctttgcaa ggactatgcc cgcagaagga gagccaaggc ctgaaaactc catcttttta ttgattctaa tgtatgaaat aaaatacgga tccagacagg aatacaggaa gtatggaggg tacacagccc ggattcaggc cacatctctc ttcttctatg tccaggccaa aacaggatat cccgtcgctg tcctgttgat cgtgggaggg caaggatgca ccatcttcaa gggcaatttg 1080 gcttcagagc tggagaactt catggggctc 1140 cgccattctc atgccttggt ctccttgtcc 1200 gaggagcagc tagaagggaa ttactccttc 1260 ctgtgggact gggaccaccg caacctgacc 1320 aatcccaaat tatgtgtttc cgaaatttac 1380 cgccaaagca aaggggacat aaacaccagg 1440 gacgtcctgc atttcacctc caccaccacg 1500 cggtaccggc cccctgacta cagggatctc 1560 ccctttaaga atgtcacaga gtatgatggg 1620 atggtggacg tggacctccc gcccaacaag 1680 ctgaagccct ggactcagta cgccgtttac 1740 aacgaccata tccgtggggc caagagtgag 1800 ccttccattc ccttggacgt tctttcagca 1860 tggaaccctc cctctctgcc caacggcaac 1920 cagcctcagg acggctacct ttaccggcac 1980 aggaagtatg ccgacggcac catcgacatt 2040 gtgtgtggtg gggagaaagg gccttgctgc 2100 gccgagaagg aggaggctga ataccgcaaa 2160 ttcgtgccca gacctgaaag gaagcggaga 2220 tccagccgaa gcaggaacac cacggccgca 2280 ctggagacag agtacccttt ctttgagagc 2340 tctaaccttc ggcctttcac attgtaccgc 2400 gagaagctgg gctgcagcgc ctccaacttc 2460 gcagatgaca ttcctgggcc agtgacctgg 2520 aagtggccgg aacctgagaa tcccaatgga 2580 tcacaagttg aggatcagcg agaatgtgtg 2640 gccaagctaa accggctaaa cccggggaac 2700 tctgggaatg ggtcgtggac agatcctgtg 2760 gaaaacttca tccatctgat catcgctctg 2820 ttggtgatta tgctgtacgt cttccataga 2880 aagagaaata acagcaggct ggggaatgga gtgctgtatg cctctgtgaa cccggagtac 2940 ttcagcgctg ctgatgtgta cgttcctgat gagtgggagg tggctcggga gaagatcacc 3000 atgagccggg aacttgggca ggggtcgttt gggatggtct atgaaggagt tgccaagggt 3060 gtggtgaaag atgaacctga aaccagagtg gccattaaaa cagtgaacga ggccgcaagc 3120 atgcgtgaga ggattgagtt tctcaacgaa gcttctgtga tgaaggagtt caattgtcac 3180 catgtggtgc gattgctggg tgtggtgtcc caaggccagc caacactggt catcatggaa 3240 ctgatgacac ggggcgatct caaaagttat ctccggtctc tgaggccaga aatggagaat 3300 aatccagtcc tagcacctcc aagcctgagc aagatgattc agatggccgg agagattgca 3360 gacggcatgg catacctcaa cgccaataag ttcgtccaca gagaccttgc tgcccggaat 3420 tgcatggtag ccgaagattt cacagtcaaa atcggagatt ttggtatgac gcgagatatc 3480 tatgagacag actattaccg gaaaggaggc aaagggctgc tgcccgtgcg ctggatgtct 3540 cctgagtccc tcaaggatgg agtcttcacc acttactcgg acgtctggtc cttcggggtc 3600 gtcctctggg agatcgccac actggccgag cagccctacc agggcttgtc caacgagcaa 3660 gtccttcgct tcgtcatgga gggcggcctt ctggacaagc cagacaactg tcctgacatg 3720 ctgtttgaac tgatgcgcat gtgctggcag tataacccca agatgaggcc ttccttcctg 3780 gagatcatca gcagcatcaa agaggagatg gagcctggct tccgggaggt ctccttctac 3840 tacagcgagg agaacaagct gcccgagccg gaggagctgg acctggagcc agagaacatg 3900 gagagcgtcc ccctggaccc ctcggcctcc tcgtcctccc tgccactgcc cgacagacac 3960 tcaggacaca aggccgagaa cggccccggc cctggggtgc tggtcctccg cgccagcttc 4020 gacgagagac agccttacgc ccacatgaac gggggccgca agaacgagcg ggccttgccg 4080 ctgccccagt cttcgacctg ctga 4104 92 726 DNA Homo sapiens PDGFB NM002608 92 atgaatcgct gctgggcgct cttcctgtct gagggggacc ccattcccga ggagctttat tttgatgatc tccaacgcct gctgcacgga gacctgaaca tgacccgctc ccactctgga aggagcctgg gttccctgac cattgctgag accgaggtgt tcgagatctc ccggcgcctc tggccgccct gtgtggaggt gcagcgctgc tgccgcccca cccaggtgca gctgcgacct aagaagccaa tctttaagaa ggccacggtg gagacagtgg cagctgcacg gcctgtgacc gccaaaacgc cccaaactcg ggtgaccatt ggcaagcacc ggaaattcaa gcacacgcat gcctag ctctgctgct acctgcgtct ggtcagcgcc 60 gagatgctga gtgaccactc gatccgctcc 120 gaccccggag aggaagatgg ggccgagttg 180 ggcgagctgg agagcttggc tcgtggaaga 240 ccggccatga tcgccgagtg caagacgcgc 300 atagaccgca ccaacgccaa cttcctggtg 360 tccggctgct gcaacaaccg caacgtgcag 420 gtccaggtga gaaagatcga gattgtgcgg 480 acgctggaag accacctggc atgcaagtgt 540 cgaagcccgg ggggttccca ggagcagcga 600 cggacggtgc gagtccgccg gccccccaag 660 gacaagacgg cactgaagga gacccttgga 720 726 93 1512 DNA Homo sapiens TGFbetaRl NM004612 93 atggaggcgg cggtcgctgc tccgcgtccc gCggCggcgg CggCggCgCt gCtCCCgggg tgtacaaaag acaattttac ttgtgtgaca accacagaca aagttataca caacagcatg gataggccgt ttgtatgtgc accctcttca tgcaatcagg accattgcaa taaaatagaa cggctgctcc tcctcgtgct ggcggcggcg 60 gcgacggcgt tacagtgttt ctgccacctc 120 gatgggctct gctttgtctc tgtcacagag 180 tgtatagctg aaattgactt aattcctcga 240 aaaactgggt ctgtgactac aacatattgc 300 cttccaacta ctgtaaagtc atcacctggc 360 cttggtcctg tggaactggc agctgtcatt gctggaccag tgtgcttcgt ctgcatctca 420 ctcatgttga tggtctatat ctgccacaac cgcactgtca ttcaccatcg agtgccaaat 480 gaagaggacc cttcattaga tcgccctttt atttcagagg gtactacgtt gaaagactta 540 atttatgata tgacaacgtc aggttctggc tcaggtttac cattgcttgt tcagagaaca 600 attgcgagaa ctattgtgtt acaagaaagc attggcaaag gtcgatttgg agaagtttgg 660 agaggaaagt ggcggggaga agaagttgct gttaagatat tctcctctag agaagaacgt 720 tcgtggttcc gtgaggcaga gatttatcaa actgtaatgt tacgtcatga aaacatcctg 780 ggatttatag cagcagacaa taaagacaat ggtacttgga ctcagctctg gttggtgtca 840 gattatcatg agcatggatc cctttttgat tacttaaaca gatacacagt tactgtggaa 900 ggaatgataa aacttgctct gtccacggcg agcggtcttg cccatcttca catggagatt 960 gttggtaccc aaggaaagcc agccattgct catagagatt tgaaatcaaa gaatatcttg 1020 gtaaagaaga atggaacttg ctgtattgca gacttaggac tggcagtaag acatgattca 1080 gccacagata ccattgatat tgctccaaac cacagagtgg gaacaaaaag gtacatggcc 1140 cctgaagttc tcgatgattc cataaatatg aaacattttg aatccttcaa acgtgctgac 1200 atctatgcaa tgggcttagt attctgggaa attgctcgac gatgttccat tggtggaatt 1260 catgaagatt accaactgcc ttattatgat cttgtacctt ctgacccatc agttgaagaa 1320 atgagaaaag ttgtttgtga acagaagtta aggccaaata tcccaaacag atggcagagc 1380 tgtgaagcct tgagagtaat ggctaaaatt atgagagaat gttggtatgc caatggagca 1440 gctaggctta cagcattgcg gattaagaaa acattatcgc aactcagtca acaggaaggc 1500 atcaaaatgt aa 1512 94 4044 DNA Homo sapiens Flkl AF035121 94 atgcagagca aggtgctgct ggccgtcgcc tctgtgggtt tgcctagtgt ttctcttgat cttacaatta aggctaatac aactcttcaa tggctttggc ccaataatca gagtggcagt gatggcctct tctgtaagac actcacaatt tacaagtgct tctaccggga aactgacttg tacagatctc catttattgc ttctgttagt aacaaaaaca aaactgtggt gattccatgt ctttgtgcaa gatacccaga aaagagattt agcaagaagg gctttactat tcccagctac gaagcaaaaa ttaatgatga aagttaccag tataggattt atgatgtggt tctgagtccg aagcttgtct taaattgtac agcaagaact gaataccctt cttcgaagca tcagcataag tctgggagtg agatgaagaa atttttgagc gaccaaggat tgtacacctg tgcagcatcc tttgtcaggg tccatgaaaa accttttgtt gaagccacgg tgggggagcg tgtcagaatc gaaataaaat ggtataaaaa tggaataccc catgtactga cgattatgga agtgagtgaa accaatccca tttcaaagga gaagcagagc ccccagattg gtgagaaatc tctaatctct caaacgctga catgtacggt ctatgccatt cagttggagg aagagtgcgc caacgagccc ccttgtgaag aatggagaag tgtggaggac aaaaatcaat ttgctctaat tgaaggaaaa gcggcaaatg tgtcagcttt gtacaaatgt agggtgatct ccttccacgt gaccaggggt cccactgagc aggagagcgt gtctttgtgg ctcacatggt acaagcttgg cccacagcct cctgtttgca agaacttgga tactctttgg ctgtggctct gcgtggagac ccgggccgcc 60 ctgcccaggc tcagcataca aaaagacata 120 attacttgca ggggacagag ggacttggac 180 gagcaaaggg tggaggtgac tgagtgcagc 240 ccaaaagtga tcggaaatga cactggagcc 300 gcctcggtca tttatgtcta tgttcaagat 360 gaccaacatg gagtcgtgta cattactgag 420 ctcgggtcca tttcaaatct caacgtgtca 480 gttcctgatg gtaacagaat ttcctgggac 540 atgatcagct atgctggcat ggtcttctgt 600 tctattatgt acatagttgt cgttgtaggg 660 tctcatggaa ttgaactatc tgttggagaa 720 gaactaaatg , tggggattga cttcaactgg 780 aaacttgtaa accgagacct aaaaacccag 840 accttaacta tagatggtgt aacccggagt 900 agtgggctga tgaccaagaa gaacagcaca 960 gcttttggaa gtggcatgga atctctggtg 1020 cctgcgaagt accttggtta cccaccccca 1080 cttgagtcca atcacacaat taaagcgggg 1140 agagacacag gaaattacac tgtcatcctt 1200 catgtggtct ctctggttgt gtatgtccca 1260 cctgtggatt cctaccagta cggcaccact 1320 cctcccccgc atcacatcca ctggtattgg 1380 agccaagctg tctcagtgac aaacccatac 1440 ttccagggag gaaataaaat tgaagttaat 1500 aacaaaactg taagtaccct tgttatccaa 1560 gaagcggtca acaaagtcgg gagaggagag 1620 cctgaaatta ctttgcaacc tgacatgcag 1680 tgcactgcag acagatctac gtttgagaac 1740 ctgccaatcc atgtgggaga gttgcccaca 1800 aaattgaatg ccaccatgtt ctctaatagc 1860 acaaatgaca ttttgatcat ggagcttaag aatgcatcct tgcaggacca aggagactat 1920 gtctgccttg ctcaagacag gaagaccaag aaaagacatt gcgtggtcag gcagctcaca 1980 gtcctagagc gtgtggcacc cacgatcaca ggaaacctgg agaatcagac gacaagtatt 2040 ggggaaagca tcgaagtctc atgcacggca tctgggaatc cccctccaca gatcatgtgg 2100 tttaaagata atgagaccct tgtagaagac tcaggcattg tattgaagga tgggaaccgg 2160 aacctcacta tccgcagagt gaggaaggag gacgaaggcc tctacacctg ccaggcatgc 2220 agtgttcttg gctgtgcaaa agtggaggca tttttcataa tagaaggtgc ccaggaaaag 2280 acgaacttgg aaatcattat tctagtaggc acggcggtga ttgccatgtt cttctggcta 2340 cttcttgtca tcatcctacg gaccgttaag cgggccaatg gaggggaact gaagacaggc 2400 tacttgtcca tcgtcatgga tccagatgaa ctcccattgg atgaacattg tgaacgactg 2460 ccttatgatg ccagcaaatg ggaattcccc agagaccggc tgaagctagg taagcctctt 2520 ggccgtggtg cctttggcca agtgattgaa gcagatgcct ttggaattga caagacagca 2580 acttgcagga cagtagcagt caaaatgttg aaagaaggag caacacacag tgagcatcga 2640 gctctcatgt ctgaactcaa gatcctcatt catattggtc accatctcaa tgtggtcaac 2700 cttctaggtg cctgtaccaa gccaggaggg ccactcatgg tgattgtgga attctgcaaa 2760 tttggaaacc tgtccactta cctgaggagc aagagaaatg aatttgtccc ctacaagacc 2820 aaaggggcac gattccgtca agggaaagac tacgttggag caatccctgt ggatctgaaa 2880 cggcgcttgg acagcatcac cagtagccag agctcagcca gctctggatt tgtggaggag 2940 aagtccctca gtgatgtaga agaagaggaa gctcctgaag atctgtataa ggacttcctg 3000 accttggagc atctcatctg ttacagcttc caagtggcta agggcatgga gttcttggca 3060 tcgcgaaagt gtatccacag ggacctggcg gcacgaaata tcctcttatc ggagaagaac 3120 gtggttaaaa tctgtgactt tggcttggcc cgggatattt ataaagatcc agattatgtc 3180 agaaaaggag atgctcgcct ccctttgaaa tggatggccc cagaaacaat ttttgacaga 3240 gtgtacacaa tccagagtga cgtctggtct tttggtgttt tgctgtggga aatattttcc 3300 ttaggtgctt ctccatatcc tggggtaaag attgatgaag aattttgtag gcgattgaaa 3360 gaaggaacta gaatgagggc ccctgattat actacaccag aaatgtacca gaccatgctg 3420 gactgctggc acggggagcc cagtcagaga cccacgtttt cagagttggt ggaacatttg 3480 ggaaatctct tgcaagctaa tgctcagcag gatggcaaag actacattgt tcttccgata 3540 tcagagactt tgagcatgga agaggattct ggactctctc tgcctacctc acctgtttcc 3600 tgtatggagg aggaggaagt atgtgacccc aaattccatt atgacaacac agcaggaatc 3660 agtcagtatc tgcagaacag taagcgaaag agccggcctg tgagtgtaaa aacatttgaa 3720 gatatcccgt tagaagaacc agaagtaaaa gtaatcccag atgacaacca gacggacagt 3780 ggtatggttc ttgcctcaga agagctgaaa actttggaag acagaaccaa attatctcca 3840 tcttttggtg gaatggtgcc cagcaaaagc agggagtctg tggcatctga aggctcaaac 3900 cagacaagcg gctaccagtc cggatatcac tccgatgaca cagacaccac cgtgtactcc 3960 agtgaggaag cagaactttt aaagctgata gagattggag tgcaaaccgg tagcacagcc 4020 cagattctcc agcctgactc gggg 4044 95 4017 DNA Homo sapiens Fltl AF063657 95 atggtcagct actgggacac cggggtcctg ctgtgcgcgc tgctcagctg tctgcttctc 60 acaggatcta gttcaggttc aaaattaaaa gatcctgaac tgagtttaaa aggcacccag 120 cacatcatgc aagcaggcca gacactgcat ctccaatgca ggggggaagc agcccataaa 180 tggtctttgc ctgaaatggt gagtaaggaa agcgaaaggc tgagcataac taaatctgcc 240 tgtggaagaa atggcaaaca attctgcagt actttaacct tgaacacagc tcaagcaaac 300 cacactggct tctacagctg caaatatcta gctgtaccta cttcaaagaa gaaggaaaca 360 gaatctgcaa tctatatatt tattagtgat acaggtagac ctttcgtaga gatgtacagt 420 gaaatccccg aaattataca catgactgaa ggaagggagc tcgtcattcc ctgccgggtt 480 acgtcaccta acatcactgt tactttaaaa aagtttccac ttgacacttt gatccctgat 540 ggaaaacgca taatctggga cagtagaaag ggcttcatca tatcaaatgc aacgtacaaa 600 gaaatagggc ttctgacctg tgaagcaaca gtcaatgggc atttgtataa gacaaactat 660 ctcacacatc gacaaaccaa tacaatcata gatgtccaaa taagcacacc acgcccagtc 720 aaattactta gaggccatac tcttgtcctc aattgtactg ctaccactcc cttgaacacg 780 agagttcaaa tgacctggag ttaccctgat gaaaaaaata agagagcttc cgtaaggcga 840 cgaattgacc aaagcaattc ccatgccaac atattctaca gtgttcttac tattgacaaa 900 atgcagaaca aagacaaagg actttatact tgtcgtgtaa ggagtggacc atcattcaaa 960 tctgttaaca cctcagtgca tatatatgat aaagcattca tcactgtgaa acatcgaaaa 1020 cagcaggtgc ttgaaaccgt agctggcaag cggtcttacc ggctctctat gaaagtgaag 1080 gcatttccct cgccggaagt tgtatggtta aaagatgggt tacctgcgac tgagaaatct 1140 gctcgctatt tgactcgtgg ctactcgtta attatcaagg acgtaactga agaggatgca 1200 gggaattata caatcttgct gagcataaaa cagtcaaatg tgtttaaaaa cctcactgcc 1260 actctaattg tcaatgtgaa accccagatt tacgaaaagg ccgtgtcatc gtttccagac 1320 ccggctctct acccactggg cagcagacaa atcctgactt gtaccgcata tggtatccct 1380 caacctacaa tcaagtggtt ctggcacccc tgtaaccata atcattccga agcaaggtgt 1440 gacttttgtt ccaataatga agagtccttt atcctggatg ctgacagcaa catgggaaac 1500 agaattgaga gcatcactca gcgcatggca ataatagaag gaaagaataa gatggctagc 1560 accttggttg tggctgactc tagaatttct ggaatctaca tttgcatagc ttccaataaa 1620 gttgggactg tgggaagaaa cataagcttt tatatcacag atgtgccaaa tgggtttcat 1680 gttaacttgg aaaaaatgcc gacggaagga gaggacctga aactgtcttg cacagttaac 1740 aagttcttat acagagacgt tacttggatt ttactgcgga cagttaataa cagaacaatg 1800 cactacagta ttagcaagca aaaaatggcc atcactaagg agcactccat cactcttaat 1860 cttaccatca tgaatgtttc cctgcaagat tcaggcacct atgcctgcag agccaggaat 1920 gtatacacag gggaagaaat cctccagaag aaagaaatta caatcagaga tcaggaagca 1980 ccatacctcc tgcgaaacct cagtgatcac acagtggcca tcagcagttc caccacttta 2040 gactgtcatg ctaatggtgt ccccgagcct cagatcactt ggtttaaaaa caaccacaaa 2100 atacaacaag agcctggaat tattttagga ccaggaagca gcacgctgtt tattgaaaga 2160 gtcacagaag aggatgaagg tgtctatcac tgcaaagcca ccaaccagaa gggctctgtg 2220 gaaagttcag catacctcac tgttcaagga acctcggaca agtctaatct ggagctgatc 2280 actctaacat gcacctgtgt ggctgcgact ctcttctggc tcctattaac cctctttatc 2340 cgaaaaatga aaaggtcttc ttctgaaata aagactgact acctatcaat tataatggac 2400 ccagatgaag ttcctttgga tgagcagtgt gagcggctcc cttatgatgc cagcaagtgg 2460 gagtttgccc gggagagact taaactgggc aaatcacttg gaagaggggc ttttggaaaa 2520 gtggttcaag catcagcatt tggcattaag aaatcaccta cgtgccggac tgtggctgtg 2580 aaaatgctga aagagggggc cacggccagc gagtacaaag ctctgatgac tgagctaaaa 2640 atcttgaccc acattggcca ccatctgaac gtggttaacc tgctgggagc ctgcaccaag 2700 caaggagggc ctctgatggt gattgttgaa tactgcaaat atggaaatct ctccaactac 2760 ctcaagagca aacgtgactt attttttctc aacaaggatg cagcactaca catggagcct 2820 aagaaagaaa aaatggagcc aggcctggaa caaggcaaga aaccaagact agatagcgtc 2880 accagcagcg aaagctttgc gagctccggc tttcaggaag ataaaagtct gagtgatgtt 2940 gaggaagagg aggattctga cggtttctac aaggagccca tcactatgga agatctgatt 3000 tcttacagtt ttcaagtggc cagaggcatg gagttcctgt cttccagaaa gtgcattcat 3060 cgggacctgg cagcgagaaa cattctttta tctgagaaca acgtggtgaa gatttgtgat 3120 tttggccttg cccgggatat ttataagaac cccgattatg tgagaaaagg agatactcga 3180 cttcctctga aatggatggc tcctgaatct atctttgaca aaatctacag caccaagagc 3240 gacgtgtggt cttacggagt attgctgtgg gaaatcttct ccttaggtgg gtctccatac 3300 ccaggagtac aaatggatga ggacttttgc agtcgcctga gggaaggcat gaggatgaga 3360 gctcctgagt actctactcc tgaaatctat cagatcatgc tggactgctg gcacagagac 3420 ccaaaagaaa ggccaagatt tgcagaactt gtggaaaaac taggtgattt gcttcaagca 3480 aatgtacaac aggatggtaa agactacatc ccaatcaatg ccatactgac aggaaatagt 3540 gggtttacat actcaactcc tgccttctct gaggacttct tcaaggaaag tatttcagct 3600 ccgaagttta attcaggaag ctctgatgat gtcagatatg taaatgcttt caagttcatg 3660 agcctggaaa gaatcaaaac ctttgaagaa cttttaccga atgccacctc catgtttgat 3720 gactaccagg gcgacagcag cactctgttg gcctctccca tgctgaagcg cttcacctgg 3780 actgacagca aacccaaggc ctcgctcaag attgacttga gagtaaccag taaaagtaag 3840 gagtcggggc tgtctgatgt cagcaggccc agtttctgcc attccagctg tgggcacgtc 3900 agcgaaggca agcgcaggtt cacctacgac cacgctgagc tggaaaggaa aatcgcgtgc 3960 tgctccccgc ccccagacta caactcggtg gtcctgtact ccaccccacc catctag 4017 96 3897 DNA Homo sapiens Flt4 XM003852 96 atgcagcggg gcgccgcgct gtgcctgcga ctggtgagtg gctactccat gacccccccg atcgacaccg gtgacagcct gtccatctcc tggccaggag ctcaggaggc gccagccacc gtgcgagact gcgagggcac agacgccagg gtacatgcca acgacacagg cagctacgtc gagggcacca cggccgccag ctcctacgtg aacaagcctg acacgctctt ggtcaacagg tccatccccg gcctcaatgt cacgctgcgc caggaggtgg tgtgggatga ccggcggggc gccctgtacc tgcagtgcga gaccacctgg ctggtgcaca tcacaggcaa cgagctctat gagctgctgg taggggagaa gctggtcctg ggtgtcacct ttgactggga ctacccaggg gagcgacgct cccagcagac ccacacagaa agccagcacg acctgggctc gtatgtgtgc gagagcaccg aggtcattgt gcatgaaaat cccatcctgg aggccacggc aggagacgag taccccccgc ccgagttcca gtggtacaag ccacatgccc tggtgctcaa ggaggtgaca ctgtggaact ccgctgctgg cctgaggcgc cccccccaga tacatgagaa ggaggcctcc caggccctca cctgcacggc ctacggggtg cggccctgga caccctgcaa gatgtttgcc gacctcatgc cacagtgccg tgactggagg atcgagagcc tggacacctg gaccgagttt ctggtgatcc agaatgccaa cgtgtctgcc ggccaggatg agcggctcat ctacttctat gaatccaagc catccgagga gctactagag gacagctaca agtacgagca tctgcgctgg ctgtggctct gcctgggact cctggacggc 60 accttgaaca tcacggagga gtcacacgtc 120 tgcaggggac agcaccccct cgagtgggct 180 ggagacaagg acagcgagga' cacgggggtg 240 ccctactgca aggtgttgct gctgcacgag 300 tgctactaca agtacatcaa ggcacgcatc 360 ttcgtgagag actttgagca gccattcatc 420 aaggacgcca tgtgggtgcc ctgtctggtg 480 tcgcaaagct cggtgctgtg gccagacggg 540 atgctcgtgt ccacgccact gctgcacgat 600 ggagaccagg acttcctttc caaccccttc 660 gacatccagc tgttgcccag gaagtcgctg 720 aactgcaccg tgtgggctga gtttaactca 780 aagcaggcag agcggggtaa gtgggtgccc 840 ctctccagca tcctgaccat ccacaacgtc 900 aaggccaaca acggcatcca gcgatttcgg 960 cccttcatca gcgtcgagtg gctcaaagga 1020 ctggtgaagc tgcccgtgaa gctggcagcg 1080 gatggaaagg cactgtccgg gcgccacagt 1140 gaggccagca caggcaccta caccctcgcc 1200 aacatcagcc tggagctggt ggtgaatgtg 1260 tcccccagca tctactcgcg tcacagccgc 1320 cccctgcctc tcagcatcca gtggcactgg 1380 cagcgtagtc tccggcggcg gcagcagcaa 1440 gcggtgaccg cgcaggatgc cgtgaacccc 1500 gtggagggaa agaataagac tgtgagcaag 1560 atgtacaagt gtgtggtctc caacaaggtg 1620 gtgaccacca tccccgacgg cttcaccatc 1680 ggccagccgg tgctcctgag ctgccaagcc 1740 taccgcctca acctgtccac gctgcacgat 1800 gcgcacggga acccgcttct gctcgactgc aagaacgtgc atctgttcgc cacccctctg 1860 gccgccagcc tggaggaggt ggcacctggg gcgcgccacg ccacgctcag cctgagtatc 1920 ccccgcgtcg cgcccgagca cgagggccac tatgtgtgcg aagtgcaaga ccggcgcagc 1980 catgacaagc actgccacaa gaagtacctg tcggtgcagg ccctggaagc ccctcggctc 2040 acgcagaact tgaccgacct cctggtgaac gtgagcgact cgctggagat gcagtgcttg 2100 gtggccggag cgcacgcgcc cagcatcgtg tggtacaaag acgagaggct gctggaggaa 2160 aagtctggag tcgacttggc ggactccaac cagaagctga gcatccagcg cgtgcgcgag 2220 gaggatgcgg gacgctatct gtgcagcgtg tgcaacgcca agggctgcgt caactcctcc 2280 gccagcgtgg ccgtggaagg ctccgaggat aagggcagca tggagatcgt gatccttgtc 2340 ggtaccggcg tcatcgctgt cttcttctgg gtcctcctcc tcctcatctt ctgtaacatg 2400 aggaggccgg cccacgcaga catcaagacg ggctacctgt ccatcatcat ggaccccggg 2460 gaggtgcctc tggaggagca atgcgaatac ctgtcctacg atgccagcca gtgggaattc 2520 ccccgagagc ggctgcacct ggggagagtg ctcggctacg gcgccttcgg gaaggtggtg 2580 gaagcctccg ctttcggcat ccacaagggc agcagctgtg acaccgtggc cgtgaaaatg 2640 ctgaaagagg gcgccacggc cagcgagcag cgcgcgctga tgtcggagct caagatcctc 2700 attcacatcg gcaaccacct caacgtggtc aacctcctcg gggcgtgcac caagccgcag 2760 ggccccctca tggtgatcgt ggagttctgc aagtacggca acctctccaa cttcctgcgc 2820 gccaagcggg acgccttcag cccctgcgcg gagaagtctc ccgagcagcg cggacgcttc 2880 cgcgccatgg tggagctcgc caggctggat cggaggcggc cggggagcag cgacagggtc 2940 ctcttcgcgc ggttctcgaa gaccgagggc ggagcgaggc gggcttctcc agaccaagaa 3000 gctgaggacc tgtggctgag cccgctgacc atggaagatc ttgtctgcta cagcttccag 3060 gtggccagag ggatggagtt cctggcttcc cgaaagtgca tccacagaga cctggctgct 3120 cggaacattc tgctgtcgga aagcgacgtg gtgaagatct gtgactttgg ccttgcccgg 3180 gacatctaca aagaccccga ctacgtccgc aagggcagtg cccggctgcc cctgaagtgg 3240 atggcccctg aaagcatctt cgacaaggtg tacaccacgc agagtgacgt gtggtccttt 3300 ggggtgcttc tctgggagat cttctctctg ggggcctccc cgtaccctgg ggtgcagatc 3360 aatgaggagt tctgccagcg gctgagagac ggcacaagga tgagggcccc ggagctggcc 3420 actcccgcca tacgccgcat catgctgaac tgctggtccg gagaccccaa ggcgagacct 3480 gcattctcgg agctggtgga gatcctgggg gacctgctcc agggcagggg cctgcaagag 3540 gaagaggagg tctgcatggc cccgcgcagc tctcagagct cagaagaggg cagcttctcg 3600 caggtgtcca ccatggccct acacatcgcc caggctgacg ctgaggacag cccgccaagc 3660 ctgcagcgcc acagcctggc cgccaggtat tacaactggg tgtcctttcc cgggtgcctg 3720 gccagagggg ctgagacccg tggttcctcc aggatgaaga catttgagga attccccatg 3780 accccaacga cctacaaagg ctctgtggac aaccagacag acagtgggat ggtgctggcc 3840 tcggaggagt ttgagcagat agagagcagg catagacaag aaagcggctt caggtag 3897 97 4071 DNA Homo sapiens KDR AF063658 97 atggagagca tctgtgggtt cttacaatta tggctttggc gatggcctct tacaagtgct tacagatctc aacaaaaaca ctttgtgcaa agcaagaagg gaagcaaaaa tataggattt aagcttgtct gaataccctt tetgggagtg gaccaaggat aggtgctgct tgcctagtgt aggctaatac ccaataatca tctgtaagac tctaccggga catttattgc aaactgtggt gatacccaga gctttactat ttaatgatga atgatgtggt taaattgtac cttcgaagca agatgaagaa tgtacacctg ggccgtcgcc ttctcttgat aactcttcaa gagtggcagt actcacaatt aactgacttg ttctgttagt gattccatgt aaagagattt tcccagctac aagttaccag tctgagtccg agcaagaact tcagcataag atttttgagc tgcagcatcc ctgtggctct ctgcccaggc attacttgca gagcaaaggg ccaaaagtga gcctcggtca gaccaacatg ctcgggtcca gttcctgatg atgatcagct tctattatgt tctcatggaa gaactaaatg aaacttgtaa accttaacta agtgggctga gcgtggagac tcagcataca ggggacagag tggaggtgac tcggaaatga tttatgtcta gagtcgtgta tttcaaatct gtaacagaat atgctggcat acatagttgt ttgaactatc tggggattga accgagacct tagatggtgt tgaccaagaa ccgggccgcc 60 aaaagacata 120 ggacttggac 180 tgagtgcagc 240 cactggagcc 300 tgttcaagat 360 cattactgag 420 caacgtgtca 480 ttcctgggac 540 ggtcttctgt 600 cgttgtaggg 660 tgttggagaa 720 cttcaactgg 780 aaaaacccag 840 aacccggagt 900 gaacagcaca 960 tttgtcaggg tccatgaaaa accttttgtt gcttttggaa gtggcatgga atctctggtg 1020 gaagccacgg tgggggagcg tgtcagaatc cctgcgaagt accttggtta cccaccccca 1080 gaaataaaat ggtataaaaa tggaataccc cttgagtcca atcacacaat taaagcgggg 1140 catgtactga cgattatgga agtgagtgaa agagacacag gaaattacac tgtcatcctt 1200 accaatccca tttcaaagga gaagcagagc catgtggtct ctctggttgt gtatgtccca 1260 ccccagattg gtgagaaatc tctaatctct cctgtggatt cctaccagta cggcaccact 1320 caaacgctga catgtacggt ctatgccatt cctcccccgc atcacatcca ctggtattgg 1380 cagttggagg aagagtgcgc caacgagccc agccaagctg tctcagtgac aaacccatac 1440 ccttgtgaag aatggagaag tgtggaggac ttccagggag gaaataaaat tgaagttaat 1500 aaaaatcaat ttgctctaat tgaaggaaaa aacaaaactg taagtaccct tgttatccaa 1560 gcggcaaatg tgtcagcttt gtacaaatgt gaagcggtca acaaagtcgg gagaggagag 1620 agggtgatct ccttccacgt gaccaggggt cctgaaatta ctttgcaacc tgacatgcag 1680 cccactgagc aggagagcgt gtctttgtgg tgcactgcag acagatctac gtttgagaac 1740 ctcacatggt acaagcttgg cccacagcct ctgccaatcc atgtgggaga gttgcccaca 1800 cctgtttgca agaacttgga tactctttgg aaattgaatg ccaccatgtt ctctaatagc 1860 acaaatgaca ttttgatcat ggagcttaag aatgcatcct tgcaggacca aggagactat 1920 gtctgccttg ctcaagacag gaagaccaag aaaagacatt gcgtggtcag gcagctcaca 1980 gtcctagagc gtgtggcacc cacgatcaca ggaaacctgg agaatcagac gacaagtatt 2040 ggggaaagca tcgaagtctc atgcacggca tctgggaatc cccctccaca gatcatgtgg 2100 *tttaaagata atgagaccct tgtagaagac tcaggcattg tattgaagga tgggaaccgg 2160 aacctcacta tccgcagagt gaggaaggag gacgaaggcc tctacacctg ccaggcatgc 2220 agtgttcttg gctgtgcaaa agtggaggca tttttcataa tagaaggtgc ccaggaaaag 2280 acgaacttgg aaatcattat tctagtaggc acggcggtga ttgccatgtt cttctggcta 2340 cttcttgtca tcatcctacg gaccgttaag cgggccaatg gaggggaact gaagacaggc 2400 tacttgtcca tcgtcatgga tccagatgaa ctcccattgg atgaacattg tgaacgactg 2460 ccttatgatg ccagcaaatg ggaattcccc agagaccggc tgaagctagg taagcctctt 2520 ggccgtggtg cctttggcca agtgattgaa gcagatgcct ttggaattga caagacagca 2580 acttgcagga cagtagcagt caaaatgttg aaagaaggag caacacacag tgagcatcga 2640 gctctcatgt ctgaactcaa gatcctcatt catattggtc accatctcaa tgtggtcaac 2700 cttctaggtg cctgtaccaa gccaggaggg ccactcatgg tgattgtgga attctgcaaa 2760 tttggaaacc tgtccactta cctgaggagc aagagaaatg aatttgtccc ctacaagacc 2820 aaaggggcac gattccgtca agggaaagac tacgttggag caatccctgt ggatctgaaa 2880 cggcgcttgg acagcatcac cagtagccag agctcagcca gctctggatt tgtggaggag 2940 aagtccctca gtgatgtaga agaagaggaa gctcctgaag atctgtataa ggacttcctg 3000 accttggagc atctcatctg ttacagcttc caagtggcta agggcatgga gttcttggca 3060 tcgcgaaagt gtatccacag ggacctggcg gcacgaaata tcctcttatc ggagaagaac 3120 gtggttaaaa tctgtgactt tggcttggcc cgggatattt ataaagatcc agattatgtc 3180 agaaaaggag atgctcgcct ccctttgaaa tggatggccc cagaaacaat ttttgacaga 3240 gtgtacacaa tccagagtga cgtctggtct tttggtgttt tgctgtggga aatattttcc 3300 ttaggtgctt ctccatatcc tggggtaaag attgatgaag aattttgtag gcgattgaaa 3360 gaaggaacta gaatgagggc ccctgattat actacaccag aaatgtacca gaccatgctg 3420 gactgctggc acggggagcc cagtcagaga cccacgtttt cagagttggt ggaacatttg 3480 ggaaatctct tgcaagctaa tgctcagcag gatggcaaag actacattgt tcttccgata 3540 tcagagactt tgagcatgga agaggattct ggactctctc tgcctacctc acctgtttcc 3600 tgtatggagg aggaggaagt atgtgacccc aaattccatt atgacaacac agcaggaatc 3660 agtcagtatc tgcagaacag taagcgaaag agccggcctg tgagtgtaaa aacatttgaa 3720 gatatcccgt tagaagaacc agaagtaaaa gtaatcccag atgacaacca gacggacagt 3780 ggtatggttc ttgcctcaga agagctgaaa actttggaag acagaaccaa attatctcca 3840 tcttttggtg gaatggtgcc cagcaaaagc agggagtctg tggcatctga aggctcaaac 3900 cagacaagcg gctaccagtc cggatatcac tccgatgaca cagacaccac cgtgtactcc 3960 agtgaggaag cagaactttt aaagctgata gagattggag tgcaaaccgg tagcacagcc 4020 cagattctcc agcctgactc ggggaccaca ctgagctctc ctcctgttta a 4071 98 1410 DNA Homo sapiens MMP1 M13509 98 atgcacagct ttcctccact gctgctgctg ctgttctggg gtgtggtgtc tcacagcttc 60 ccagcgactc tagaaacaca agagcaagat gtggacttag tccagaaata cctggaaaaa 120 tactacaacc tgaagaatga tgggaggcaa gttgaaaagc ggagaaatag tggcccagtg 180 gttgaaaaat tgaagcaaat gcaggaattc tttgggctga aagtgactgg gaaaccagat 240 gctgaaaccc tgaaggtgat gaagcagccc agatgtggag tgcctgatgt ggctcagttt 300 gtcctcactg agggaaaccc tcgctgggag caaacacatc tgaggtacag gattgaaaat 360 tacacgccag atttgccaag agcagatgtg gaccatgcca ttgagaaagc cttccaactc 420 tggagtaatg tcacacctct gacattcacc aaggtctctg agggtcaagc agacatcatg 480 atatcttttg tcaggggaga tcatcgggac aactctcctt ttgatggacc tggaggaaat 540 cttgctcatg cttttcaacc aggcccaggt attggagggg atgctcattt tgatgaagat 600 gaaaggtgga ccaacaattt cagagagtac aacttacatc gtgttgcggc tcatgaactc 660 ggccattctc ttggactctc ccattctact gatatcgggg ctttgatgta ccctagctac 720 accttcagtg gtgatgttca gctagctcag gatgacattg atggcatcca agccatatat 780 ggacgttccc aaaatcctgt ccagcccatc ggcccacaaa ccccaaaagc gtgtgacagt 840 aagctaacct ttgatgctat aactacgatt cggggagaag tgatgttctt taaagacaga 900 ttctacatgc gcacaaatcc cttctacccg gaagttgagc tcaatttcat ttctgttttc 960 tggccacaac tgccaaatgg gcttgaagct gcttacgaat ttgccgacag agatgaagtc 1020 cggtttttca aagggaataa gtactgggct gttcagggac agaatgtgct acacggatac 1080 cccaaggaca tctacagctc ctttggcttc cctagaactg tgaagcatat cgatgctgct 1140 ctttctgagg aaaacactgg aaaaacctac ttctttgttg ctaacaaata ctggaggtat 1200 gatgaatata aacgatctat ggatccaagt tatcccaaaa tgatagcaca tgactttcct 1260 ggaattggcc acaaagttga tgcagttttc atgaaagatg gatttttcta tttctttcat 1320 ggaacaagac aatacaaatt tgatcctaaa acgaagagaa ttttgactct ccagaaagct 1380 aatagctggt tcaactgcag gaaaaattga 1410 99 1743 DNA Homo sapiens MMP10 XM006269 99 aaagaaggta agggcagtga gaatgatgca tcttgcattc cttgtgctgt tgtgtctgcc 60 agtctgctct gcctatcctc tgagtggggc agcaaaagag gaggactcca acaaggatct 120 tgcccagcaa tacctagaaa agtactacaa cctcgaaaag gatgtgaaac agtttagaag 180 aaaggacagt aatctcattg ttaaaaaaat ccaaggaatg cagaagttcc ttgggttgga 240 ggtgacaggg aagctagaca ctgacactct ggaggtgatg cgcaagccca ggtgtggagt 300 tcctgacgtt ggtcacttca gctcctttcc tggcatgccg aagtggagga aaacccacct 360 tacatacagg attgtgaatt atacaccaga tttgccaaga gatgctgttg attctgccat 420 tgagaaagct ctgaaagtct gggaagaggt gactccactc acattctcca ggctgtatga 480 aggagaggct gatataatga tctcttttgc agttaaagaa catggagact tttactcttt 540 tgatggccca ggacacagtt tggctcatgc ctacccacct ggacctgggc tttatggaga 600 tattcacttt gatgatgatg aaaaatggac agaagatgca tcaggcacca atttattcct 660 cgttgctgct catgaacttg gccactccct ggggctcttt cactcagcca acactgaagc 720 tttgatgtac ccactctaca actcattcac agagctcgcc cagttccgcc tttcgcaaga 780 tgatgtgaat ggcattcagt ctctctacgg acctccccct gcctctactg aggaacccct 840 ggtgcccaca aaatctgttc cttcgggatc tgagatgcca gccaagtgtg atcctgcttt 900 gtccttcgat gccatcagca ctctgagggg agaatatctg ttctttaaag acagatattt 960 ttggcgaaga tcccactgga accctgaacc tgaatttcat ttgatttctg cattttggcc 1020 ctctcttcca tcatatttgg atgctgcata tgaagttaac agcagggaca ccgtttttat 1080 ttttaaagga aatgagttct gggccatcag aggaaatgag gtacaagcag gttatccaag 1140 aggcatccat accctgggtt ttcctccaac cataaggaaa attgatgcag ctgtttctga 1200 caaggaaaag aagaaaacat acttctttgc agcggacaaa tactggagat ttgatgaaaa 1260 tagccagtcc atggagcaag gcttccctag actaatagct gatgactttc caggagttga 1320 gcctaaggtt gatgctgtat tacaggcatt tggatttttc tacttcttca gtggatcatc 1380 acagtttgag tttgacccca atgccaggat ggtgacacac atattaaaga gtaacagctg 1440 gttacattgc taggcgagat agggggaaga cagatatggg tgtttttaat aaatctaata 1500 attattcatc taatgtatta gaagaagatg agccttgcag acttgctttt gaattgcact atgtattttc atagatgtgt ctt 100 1467 DNA Homo sapiens MMP11 XM009873 tgagccaaaa tggttaattt ttcctgcatg ttctgtgact 1560 atatctgcat gtgtcatgaa gaatgtttct ggaattcttc 1620 gaacagaatt aagaaatact catgtgcaat aggtgagaga 1680 tattacttcc tcaataaaaa gttttatttt gggcctgttc 1740 1743 100 atggctccgg ccgcctggct ccgcagcgcg gccgcgcgcg ccctcctgcc cccgatgctg 60 ctgctgctgc tccagccgcc gccgctgctg gcccgggctc tgccgccgga cgcccaccac 120 ctccatgccg agaggagggg gccacagccc tggcatgcag ccctgcccag tagcccggca 180 cctgcccctg ccacgcagga agccccccgg cctgccagca gcctcaggcc tccccgctgt 240 ggcgtgcccg acccatctga tgggctgagt gcccgcaacc gacagaagag gttcgtgctt 300 tetggcgggc gctgggagaa gacggacctc acctacagga tccttcggtt cccatggcag 360 ttggtgcagg agcaggtgcg gcagacgatg gcagaggccc taaaggtatg gagcgatgtg 420 acgccactca cctttactga ggtgcacgag ggccgtgctg acatcatgat cgacttcgcc 480 aggtactggc atggggacga cctgccgttt gatgggcctg ggggcatcct ggcccatgcc 540 ttcttcccca agactcaccg agaaggggat gtccacttcg actatgatga gacctggact 600 atcggggatg accagggcac agacctgctg caggtggcag cccatgaatt tggccacgtg 660 ctggggctgc agcacacaac agcagccaag gccctgatgt ccgccttcta cacctttcgc 720 tacccactga gtctcagccc agatgactgc aggggcgttc aacacctata tggccagccc 780 tggcccactg tcacctccag gaccccagcc ctgggccccc aggctgggat agacaccaat 840 gagattgcac cgctggagcc agacgccccg ccagatgcct gtgaggcctc ctttgacgcg 900 gtctccacca tccgaggcga gctctttttc ttcaaagcgg gctttgtgtg gcgcctccgt 960 gggggccagc tgcagcccgg ctacccagca ttggcctctc gccactggca gggactgccc 1020 agccctgtgg acgctgcctt cgaggatgcc cagggccaca tttggttctt ccaaggtgct 1080 cagtactggg tgtacgacgg tgaaaagcca gtcctgggcc ccgcacccct caccgagctg 1140 ggcctggtga ggttcccggt ccatgctgcc ttggtctggg gtcccgagaa gaacaagatc 1200 tacttcttcc gaggcaggga ctactggcgt ttccacccca gcacccggcg tgtagacagt 1260 cccgtgcccc gcagggccac tgactggaga ggggtgccct ctgagatcga cgctgccttc 1320 caggatgctg atggctatgc ctacttcctg cgcggccgcc tctactggaa gtttgaccct 1380 gtgaaggtga aggctctgga aggcttcccc cgtctcgtgg gtcctgactt ctttggctgt 1440 gccgagcctg ccaacacttt cctctga 1467 101 1653 DNA Homo sapiens MMP12 XM006272 101 atgaagtttc ttctaatact gctcctgcag gccactgctt ctggagctct tcccctgaac 60 agctctacaa gcctggaaaa aaataatgtg ctatttggtg agagatactt agaaaaattt 120 tatggccttg agataaacaa acttccagtg acaaaaatga aatatagtgg aaacttaatg 180 aaggaaaaaa tccaagaaat gcagcacttc ttgggtctga aagtgaccgg gcaactggac 240 acatctaccc tggagatgat gcacgcacct cgatgtggag tccccgatgt ccatcatttc 300 agggaaatgc caggggggcc cgtatggagg aaacattata tcacctacag aatcaataat 360 tacacacctg acatgaaccg tgaggatgtt gactacgcaa tccggaaagc tttccaagta 420 tggagtaatg ttaccccctt gaaattcagc aagattaaca caggcatggc tgacattttg 480 gtggtttttg cccgtggagc tcatggagac ttccatgctt ttgatggcaa aggtggaatc 540 ctagcccatg cttttggacc tggatctggc attggagggg atgcacattt cgatgaggac 600 gaattctgga ctacacattc aggagnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 660 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 720 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 780 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 840 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 900 nnnnnnnnnn nnnnnnnnnn nnnnngagag gatccaaagg ccgtaatgtt ccccacctac 960 aaatatgttg acatcaacac atttcgcctc tctgctgatg acatacgtgg cattcagtcc 1020 ctgtatggag acccaaaaga gaaccaacgc ttgccaaatc ctgacaattc agraccagct 1080 1200 1260 tttaagacca 1320 gaaaaaaatt 1380 taaccagtat 1440 gattaccaag 1500 actctaaaaa caaatactac tatcaccaaa ctctgtgacc ccaatttgag ttttgatgct gtcactaccg tgggaaataa gatctttttc 1140 ttcaaagaca ggttcttctg gctgaaggtt tctgagagac caaagaccag tgttaattta atttcttcct tatggccaac cttgccatct ggcattgaag ctgcttatga aattgaagcc agaaatcaag tttttctttt taaagatgac aaatactggt taattagcaa gagccaaatt atcccaagag catacattct tttggttttc ctaactttgt gatgcagctg tttttaaccc acgtttttat aggacctact tctttgtaga 1560 1620 1653 tggaggtatg atgaaaggag acagatgatg gaccctggtt atcccaaact tactccaacg aacttccaag gaatcgggcc taaaattgat gcagtcttct tatttcttcc aaggatctaa ccaatttgaa tatgacttcc acactgaaaa gcaatagctg gtttggttgt tag 102 1416 DNA Homo sapiens 102 atgcatccag ccccttccca cgctacctga gcaagctcca ggcaaacttg gtgggtgaat agaattgtga gggtcctggc gtggtggtga gatcatacta tgactgagag acgataacac acaatgtttt attacacccc tgccttcctc tgaagatgat ccatcctaca gctccgagaa cttagatgtc ccctcgaact tgatatgact ttcttgagct ttgtctgagg aatctcgcgg atgcagtctt atgaaaaagc cttaaatggt cattctgaag ggactcattg aagacctcca gaatcctgaa tcttcggctt caagatgcgg ccaaaatgaa tcgaaaaggc tcgggccctg 60 gtttgcagag 120 ggagaatgca 180 agaggtgact 240 ggttcctgat 300 tttaacctac 360 attcaaaaaa 420 gccttcaaag tttggtccga tgtaactcct ctgaatttta ccagacttca gctgacatca tgatctcttt tggaattaag gagcatggcg acttctaccc ccctctggcc tgctggctca tgcttttcct cctgggccaa attatggagg tttgatgatg atgaaacctg gacaagtagt tccaaaggct acaacttgtt gcgcatgagt tcggccactc cttaggtctt gaccactcca aggaccctgg tttcctatct acacctacac cggcaaaagc cactttatgc ttcctgatga gggatccagt ctctctatgg tccaggagat gaagacccca accctaaaca ccagacaaat gtgacccttc cttatccctt gatgccatta ccagtctccg atgatcttta aagacagatt cttctggcgc ctgcatcctc agcaggttga tttttaacga aatcattttg gccagaactt cccaaccgta ttgatgctgc ccttctcatg acctcatctt catcttcaga ggtagaaaat tttgggctct gacattctgg aaggttatcc caaaaaaata tctgaactgg gtcttccaaa aagataagtg cagctgttca ctttgaggat acaggcaaga ctctcctgtt caggtctgga gatatgatga tactaaccat attatggata aagactatcc gaagaagact tcccaggaat tggtgataaa gtagatgctg tctatgagaa atctattttt tcaacggacc catacagttt gaatacagca tctggagtaa cgcgtcatgc cagcaaattc cattttgtgg tgttaa 103 1749 DNA Homo sapiens cgatggcatt 480 atttgatggg 540 agatgcccat 600 tcttgttgct 660 agcactcatg 720 cgatgtacaa 780 tccaaaaacg 840 aggagaaaca 900 tgcggagctg 960 atatgagcac 1020 taatggttat 1080 agaagttaag 1140 ctcaggaaac 1200 gagactaata 1260 aaatggttat 1320 ccgtattgtt 1380 1416 MMP14 NM004995 103 atgtctcccg ccccaagacc cccccgttgt ctcctgctcc ccctgctcac gctcggcacc 60 gcgctcgcct ccctcggctc ggcccaaagc agcagcttca gccccgaagc ctggctacag 120 caatatggct acctgcctcc cggggaccta cgtacccaca cacagcgctc accccagtca 180 ctctcagcgg ccatcgctgc catgcagaag ttttacggct tgcaagtaac aggcaaagct 240 gatgcagaca ccatgaaggc catgaggcgc ccccgatgtg gtgttccaga caagtttggg 300 gctgagatca aggccaatgt tcgaaggaag cgctacgcca tccagggtct caaatggcaa 360 cataatgaaa tcactttctg catccagaat tacaccccca aggtgggcga gtatgccaca 420 tacgaggcca ttcgcaaggc gttccgcgtg tgggagagtg ccacaccact gcgcttccgc 480 gaggtgccct atgcctacat ccgtgagggc catgagaagc aggccgacat catgatcttc 540 tttgccgagg gcttccatgg cgacagcacg cccttcgatg gtgagggcgg cttcctggcc 600 catgcctact tcccaggccc caacattgga ggagacaccc actttgactc tgccgagcct 660 tggactgtca ggaatgagga tctgaatgga aatgacatct tcctggtggc tgtgcacgag 720 ctgggccatg ccctggggct cgagcattcc agtgacccct cggccatcat ggcacccttt 780 taccagtgga tggacacgga gaattttgtg ctgcccgatg atgaccgccg gggcatccag 840 caactttatg ggggtgagtc agggttcccc accaagatgc cccctcaacc caggactacc 900 tcccggcctt ctgttcctga taaacccaaa aaccccacct atgggcccaa catctgtgac 960 gggaactttg acaccgtggc catgctccga ggggagatgt ttgtcttcaa ggagcgctgg 1020 ttctggcggg tgaggaataa ccaagtgatg gatggatacc caatgcccat tggccagttc 1080 tggcggggcc tgcctgcgtc catcaacact gcctacgaga ggaaggatgg caaattcgtc 1140 ttcttcaaag gagacaagca ttgggtgttt gatgaggcgt ccctggaacc tggctacccc 1200 aagcacatta aggagctggg ccgagggctg cctaccgaca agattgatgc tgctctcttc 1260 tggatgccca atggaaagac ctacttcttc cgtggaaaca agtactaccg tttcaacgaa 1320 gagctcaggg cagtggatag cgagtacccc aagaacatca aagtctggga agggatccct 1380 gagtctccca gagggtcatt catgggcagc gatgaagtct tcacttactt ctacaagggg 1440 aacaaatact ggaaattcaa caaccagaag ctgaaggtag aaccgggcta ccccaagtca 1500 gccctgaggg actggatggg ctgcccatcg ggaggccggc cggatgaggg gactgaggag 1560 gagacggagg tgatcatcat tgaggtggac gaggagggcg gcggggcggt gagcgcggct 1620 gccgtggtgc tgcccgtgct gctgctgctc ctggtgctgg cggtgggcct tgcagtcttc 1680 ttcttcagac gccatgggac ccccaggcga ctgctctact gccagcgttc cctgctggac 1740 aaggtctga 1749 104 2010 DNA Homo sapiens MMP15 NM002428 104 atgggcagcg acccgagcgc gcccggacgg ccgggctgga cgggcagcct cctcggcgac 60 cgggaggagg cggcgcggcc gcgactgctg ccgctgctcc tggtgcttct gggctgcctg 120 ggccttggcg tagcggccga agacgcggag gtccatgccg agaactggct gcggctttat 180 ggctacctgc ctcagcccag ccgccatatg tccaccatgc gttccgccca gatcttggcc 240 tcggcccttg cagagatgca gcgcttctac gggatcccag tcaccggtgt gctcgacgaa 300 gagaccaagg agtggatgaa gcggccccgc tgtggggtgc cagaccagtt cggggtacga 360 gtgaaagcca acctgcggcg gcgtcggaag cgctacgccc tcaccgggag gaagtggaac 420 aaccaccatc tgacctttag catccagaac tacacggaga agttgggctg gtaccactcg 480 atggaggcgg tgcgcagggc cttccgcgtg tgggagcagg ccacgcccct ggtcttccag 540 gaggtgccct atgaggacat ccggctgcgg cgacagaagg aggccgacat catggtactc 600 tttgcctctg gcttccacgg cgacagctcg ccgtttgatg gcaccggtgg ctttctggcc 660 cacgcctatt tccctggccc cggcctaggc ggggacaccc attttgacgc agatgagccc 720 tggaccttct ccagcactga cctgcatgga aacaacctct tcctggtggc agtgcatgag 780 ctgggccacg cgctggggct ggagcactcc agcaacccca atgccatcat ggcgccgttc 840 taccagtgga aggacgttga caacttcaag ctgcccgagg acgatctccg tggcatccag 900 cagctctacg gtaccccaga cggtcagcca cagcctaccc agcctctccc cactgtgacg 960 ccacggcggc caggccggcc tgaccaccgg ccgccccggc ctccccagcc accaccccca 1020 ggtgggaagc cagagcggcc cccaaagccg ggccccccag tccagccccg agccacagag 1080 cggcccgacc agtatggccc caacatctgc gacggggact ttgacacagt ggccatgctt 1140 cgcggggaga tgttcgtgtt caagggccgc tggttctggc gagtccggca caaccgcgtc 1200 ctggacaact atcccatgcc catcgggcac ttctggcgtg gtctgcccgg tgacatcagt 1260 gctgcctacg agcgccaaga cggtcgtttt gtctttttca aaggtgaccg ctactggctc 1320 tttcgagaag cgaacctgga gcccggctac ccacagccgc tgaccagcta tggcctgggc 1380 atcccctatg accgcattga cacggccatc tggtgggagc ccacaggcca caccttcttc 1440 ttccaagagg acaggtactg gcgcttcaac gaggagacac agcgtggaga ccctgggtac 1500 cccaagccca tcagtgtctg gcaggggatc cctgcctccc ctaaaggggc cttcctgagc 1560 aatgacgcag cctacaccta cttctacaag ggcaccaaat actggaaatt cgacaatgag 1620 cgcctgcgga tggagecegg ctaccccaag tccatcctgc gggacttcat gggctgccag 1680 gagcacgtgg agccaggccc ccgatggccc gacgtggccc ggccgccctt caacccccac 1740 gggggtgcag agcccggggc ggacagcgca gagggcgacg tgggggatgg ggatggggac 1800 tttggggccg gggtcaacaa ggaeggggge agccgcgtgg tggtgcagat ggaggaggtg 1860 gcacggacgg tgaacgtggt gatggtgctg gtgccactgc tgetgetget ctgcgtcctg 1920 ggcctcacct acgcgctggt gcagatgcag cgcaagggtg cgccacgtgt cctgctttac 1980 tgcaagcgct cgctgcagga gtgggtctga 2010 105 1824 DNA Home ) sapiens MMP16 NM005941 105 atgatcttac tcacattcag cactggaaga cggttggatt tegtgeatea ttcgggggtg 60 tttttcttgc aaaccttget ttggatttta tgtgctacag tetgeggaac ggagcagtat 120 ttcaatgtgg aggtttggtt acaaaagtac ggctaccttc caccgactga ccccagaatg 180 tcagtgctgc getctgeaga gaecatgeag tctgccctag ctgccatgca gcagttctat 240 ggcattaaca tgacaggaaa agtggacaga aacacaattg actggatgaa gaagccccga 300 tgcggtgtac ctgaccagac aagaggtagc tccaaatttc atattegteg aaagegatat 360 gcattgacag gacagaaatg gcagcacaag cacatcactt acagtataaa gaaegtaact 420 ccaaaagtag gagaccctga gaetegtaaa gctattcgcc gtgcctttga tgtgtggcag 480 aatgtaactc ctctgacatt tgaagaagtt ccctacagtg aattagaaaa tggcaaacgt 540 gatgtggata taaccattat ttttgeatet ggtttccatg gggacagctc tccctttgat 600 ggagagggag gatttttggc acatgcctac ttccctggac caggaattgg aggagatacc 660 cattttgact cagatgagee atggacacta ggaaatccta atcatgatgg aaatgactta 720 tttcttgtag cagtccatga actgggacat gctctgggat tggagcattc caatgacccc 780 actgccatca tggctccatt ttaccagtac atggaaacag acaacttcaa actacctaat 840 gatgatttac agggcatcca gaaaatatat ggtccacctg acaagattcc tccacctaca 900 agacctctac cgacagtgcc cccacaccgc tctattcctc cggctgaccc aaggaaaaat 960 gacaggccaa aacctcctcg gcctccaacc ggcagaccct cctatcccgg agccaaaccc 1020 aacatctgtg atgggaactt taacactcta gctattcttc gtcgtgagat gtttgttttc 1080 aaggaccagt ggttttggcg agtgagaaac aacagggtga tggatggata cccaatgcaa 1140 attacttact tetggcgggg cttgcctcct agtatcgatg cagtttatga aaatagcgac 1200 gggaattttg tgttctttaa aggtaacaaa tattgggtgt tcaaggatac aactcttcaa 1260 cctggttacc ctcatgactt gataaccctt ggaagtggaa ttccccctca tggtattgat 1320 tcagccattt ggtgggagga cgtcgggaaa acctatttct tcaagggaga cagatattgg 1380 agatatagtg aagaaatgaa aacaatggac cctggctatc ccaagccaat cacagtctgg 1440 aaagggatcc ctgaatctcc tcagggagca tttgtacaca aagaaaatgg ctttacgtat 1500 ttctacaaag gaaaggagta ttggaaattc aacaaccaga tactcaaggt agaacctgga 1560 catccaagat ccatcctcaa ggattttatg ggctgtgatg gaccaacaga cagagttaaa 1620 gaaggacaca gcccaccaga tgatgtagac attgtcatca aactggacaa cacagccagc 1680 actgtgaaag ccatagctat tgtcattccc tgcatcttgg ccttatgcct ccttgtattg 1740 gtttacactg tgttccagtt caagaggaaa ggaacacccc gccacatact gtactgtaaa 1800 cgctctatgc aagagtgggt gtga 1824 106 1560 DNA Homo sapiens MMP17 NM004141 106 atgcagcagt ttggtggcct ggaggccacc ggcatcctgg acgaggccac cctggccctg 60 atgaaaaccc cacgctgctc cctgccagac ctccctgtcc tgacccaggc tcgcaggaga 120 cgccaggctc cagcccccac caagtggaac aagaggaacc tgtcgtggag ggtccggacg 180 ttcccacggg actcaccact ggggcacgac acggtgcgtg cactcatgta ctacgccctc 240 aaggtctgga gcgacattgc gcccctgaac ttccacgagg tggcgggcag caccgccgac 300 atccagatcg acttctccaa ggccgaccat aacgacggct accccttcga cggccccggc 360 ggcaccgtgg cccacgcctt cttccccggc caccaccaca ccgccgggga cacccacttt 420 gacgatgacg aggcctggac cttccgctcc tcggatgccc acgggatgga cctgtttgca 480 gtggctgtcc acgagtttgg ccacgccatt gggttaagcc atgtggccgc tgcacactcc 540 atcatgcggc cgtactacca gggcccggtg ggtgacccgc tgcgctacgg gctcccctac 600 gaggacaagg tgcgcgtctg gcagctgtac ggtgtgcggg agtctgtgtc tcccacggcg 660 cagcccgagg agcctcccct gctgccggag cccccagaca accggtccag cgccccgccc 720 aggaaggacg tgccccacag atgcagcact cactttgacg cggtggccca gatccggggt 780 gaagctttct tcttcaaagg caagtacttc tggcggctga cgcgggaccg gcacctggtg 840 tccctgcagc cggcacagat gcaccgcttc tggcggggcc tgccgctgca cctggacagc 900 gtggacgccg tgtacgagcg caccagcgac cacaagatcg tcttctttaa aggagacagg 960 tactgggtgt tcaaggacaa taacgtagag gaaggatacc cgcgccccgt ctccgacttc 1020 agcctcccgc ctggcggcat cgacgctgcc ttctcctggg cccacaatga caggacttat 1080 ttctttaagg accagctgta ctggcgctac gatgaccaca cgaggcacat ggaccccggc 1140 taccccgccc agagccccct gtggaggggt gtccccagca cgctggacga cgccatgcgc 1200 tggtccgacg gtgcctccta cttcttccgt ggccaggagt actggaaagt gctggatggc 1260 gagctggagg tggcacccgg gtacccacag tccacggccc gggactggct ggtgtgtgga 1320 gactcacagg ccgatggatc tgtggctgcg ggcgtggacg cggcagaggg gccccgcgcc 1380 cctccaggac aacatgacca gagccgctcg gaggacggtt acgaggtctg ctcatgcacc 1440 tctggggcat cctctccccc gggggcccca ggcccactgg tggctgccac catgctgctg 1500 ctgctgccgc cactgtcacc aggcgccctg tggacagcgg cccaggccct gacgctatga 1560 107 1983 DNA Homo sapiens MMP2 NM004530 107 atggaggcgc taatggcccg gggcgcgctc ggctgcctgc tgagccacgc cgccgccgcg gtcgccccca aaacggacaa agagttggca cccaaggaga gctgcaacct gtttgtgctg tttggactgc cccagacagg tgatcttgac cgctgcggca acccagatgt ggccaactac aagaaccaga tcacatacag gatcattggc gatgatgcct ttgctcgtgc cttccaagtc cgaatccatg atggagaggc agacatcatg ggatacccct ttgacggtaa ggacggactc gttgggggag actcccattt tgatgacgat gtccgtgtga agtatggcaa cgccgatggg ggcaaggagt acaacagctg cactgatact accacctaca actttgagaa ggatggcaag accatgggcg gcaacgctga aggacagccc tcctatgaca gctgcaccac tgagggccgc gaggactacg accgcgacaa gaagtatggc ggtgggaact cagaaggtgc cccctgtgtc gagagctgca ccagcgccgg ccgcagtgac tacgatgacg accgcaagtg gggcttctgc gcagcccacg agtttggcca cgccatgggg atggcaccca tttacaccta caccaagaac attcaggagc tctatggggc ctctcctgac ctgggccctg tcactcctga gatctgcaaa atccgtggtg agatcttctt cttcaaggac gacaagccca tggggcccct gctggtggcc gatgcggtat acgaggcccc acaggaggag acgggtcccc tgagggcgct ctgtctcctg 60 ccgtcgccca tcatcaagtt ccccggcgat 120 gtgcaatacc tgaacacctt ctatggctgc 180 aaggacacac taaagaagat gcagaagttc 240 cagaatacca tcgagaccat gcggaagcca 300 aacttcttcc ctcgcaagcc caagtgggac 360 tacacacctg atctggaccc agagacagtg 420 tggagcgatg tgaccccact gcggttttct 480 atcaactttg gccgctggga gcatggcgat 540 ctggctcatg ccttcgcccc aggcactggt 600 gagctatgga ccttgggaga aggccaagtg 660 gagtactgca agttcccctt cttgttcaat 720 ggccgcagcg atggcttcct ctggtgctcc 780 tacggcttct gtccccatga agccctgttc 840 tgcaagtttc cattccgctt ccagggcaca 900 acggatggct accgctggtg cggcaccact 960 ttctgccctg agaccgccat gtccactgtt 1020 ttccccttca ctttcctggg caacaaatat 1080 ggaaagatgt ggtgtgcgac cacagccaac 1140 cctgaccaag ggtacagcct gttcctcgtg 1200 ctggagcact cccaagaccc tggggccctg 1260 ttccgtctgt cccaggatga catcaagggc 1320 attgaccttg gcaccggccc cacccccaca 1380 caggacattg tatttgatgg catcgctcag 1440 cggttcattt ggcggactgt gacgccacgt 1500 acattctggc ctgagctccc ggaaaagatt 1560 aaggctgtgt tctttgcagg gaatgaatac 1620 tggatctact cagccagcac cctggagcga gggtacccca agccactgac ctgccccctg atgtccagcg agtggatgcc gcctttaact ggagcaaaaa tacatctttg ctggagacaa attctggaga tacaatgagg tgaagaagaa ggctttccca agctcatcgc agatgcctgg aatgccatcc ccgataacct gtggacctgc agggcggcgg tcacagctac ttcttcaagg gtgcctatta gagaaccaaa gtctgaagag cgtgaagttt ggaagcatca aatccgactg tga cagcctggga 1680 caagaagaca 1740 aatggatcct 1800 ggatgccgtc 1860 cctgaagctg 1920 gctaggctgc 1980 1983 108 1434 DNA Homo sapiens MMP2 XM006271 MMP3 XM006271 108 atgaagagtc gatggagctg tactacgacc gttaaaaaaa tccgacactc agaacctttc tatacaccag tgggaagagg atctcttttg ttccaatcct caaggggtga tcgaaaaaga tccgagaaat tggaggtgat ctggcatccc atttgccaaa tgactccact cagttagaga actgttgctg ggacaccagc tgtgaaacag gcagaagttc gcgcaagccc gaagtggagg agatgctgtt cacattctcc acatggagac tgcgtggcag atgaaccttg tttgttagga cttggattgg aggtgtggag aaaacccacc gattctgctg aggctgtatg ttttaccctt tttgctcagc ttcagaaata gaaaggacag aggtgacggg ttcctgacgt ttacatacag ttgagaaagc aaggagaggc ttgatggacc ctatccattg 60 tctagaaaac 120 tggtcctgtt 180 gaagctggac 240 tggtcacttc 300 gattgtgaat 360 tctgaaagtc 420 tgatataatg 480 tggaaatgtt 540 ttggcccatg gaacaatgga ggccactccc cactcactca tccctctatg cctccagaac actctgaggg aagcttgaac gatgccgcat tgggccatca ttccctccaa tatttctttg ggctttccca tttgaagaat aatgcaaaga cctatgcccc caaaggatac tgggtctctt cagacctgac gacctccccc ctgggacgcc gagaaatcct ctgaattgca atgaagttac gaggaaatga ccgtgaggaa tagaggacaa agcaaatagc ttgggttctt aagtgacaca tgggccaggg aacagggacc tcactcagcc tcggttccgc tgactcccct agccaactgt gatctttaaa tttgatctct tagcaaggac ggtacgagct aatcgatgca atactggaga tgaagacttt ttatttcttt cactttgaag attaatggag aatttatttc aacactgaag ctgtctcaag gagacccccc gatcctgctt gacaggcact tcattttggc ctcgttttca ggatacccaa gccatttctg tttgatgaga ccagggattg actggatctt agtaacagct atgcccactt tcgttgctgc ctttgatgta atgatataaa tggtacccac tgtcctttga tttggcgcaa catctcttcc tttttaaagg gaggcatcca ataaggaaaa agagaaattc actcaaagat cacagttgga ggcttaattg tgatgatgat 600 tcatgaaatt 660 cccactctat 720 tggcattcag 780 ggaacctgtc 840 tgctgtcagc 900 atccctcagg 960 ttcaggcgtg 1020 aaatcaattc 1080 caccctaggt 1140 gaacaaaaca 1200 catggagcca 1260 tgatgctgtt 1320 gtttgaccca 1380 ttga 1434 109 1404 DNA Homo sapiens MMP8 NM002424 109 atgttctccc tgaagacgct tccatttctg ctcttactcc atgtgcagat tttcctgtat cttctaaaga gaaaaataca aaaactgttc aggactacct taccaattac caagcaacca gtatcagtct acaaggaaga atggcactaa gaaaagctta aagaaatgca gcgatttttt gggttgaatg tgacggggaa gaaactctgg acatgatgaa aaagcctcgc tgtggagtgc ctgacagtgg ttaaccccag gaaaccccaa gtgggaacgc actaacttga cctacaggat ttccaaggcc 60 ggaaaagttc 120 tgtgatcgtt 180 gccaaatgag 240 tggttttatg 300 tcgaaactat 360 accccacagc tgtcagaggc tgaggtagaa agagctatca aggatgcctt tgaactctgg 420 agtgttgcat cacctctcat cttcaccagg atctcacagg gagaggcaga tatcaacatt 480 gctttttacc aaagagatca cggtgacaat tctccatttg atggacccaa tggaatcctt 540 gctcatgcct ttcagccagg ccaaggtatt ggaggagatg ctcattttga tgccgaagaa 600 acatggacca acacctccgc aaattacaac ttgtttcttg ttgctgctca tgaatttggc 660 cattctttgg ggctcgctca ctcctctgac cctggtgcct tgatgtatcc caactatgct 720 ttcagggaaa ccagcaacta ctcactccct caagatgaca tcgatggcat tcaggccatc 780 tatggacttt caagcaaccc tatccaacct actggaccaa gcacacccaa accctgtgac 840 cccagtttga catttgatgc tatcaccaca ctccgtggag aaatactttt ctttaaagac 900 aggtacttct ggagaaggca tcctcagcta caaagagtcg aaatgaattt tatttctcta 960 ttctggccat cccttccaac tggtatacag gctgcttatg aagattttga cagagacctc 1020 attttcctat ttaaaggcaa ccaatactgg gctctgagtg gctatgatat tctgcaaggt 1080 tatcccaagg atatatcaaa ctatggcttc cccagcagcg tccaagcaat tgacgcagct 1140 gttttctaca gaagtaaaac atacttcttt gtaaatgacc aattctggag atatgataac 1200 caaagacaat tcatggagcc aggttatccc aaaagcatat caggtgcctt tccaggaata 1260 gagagtaaag ttgatgcagt tttccagcaa gaacatttct tccatgtctt cagtggacca 1320 agatattacg catttgatct tattgctcag agagttacca gagttgcaag aggcaataaa 1380 tggcttaact gtagatatgg ctga 1404 110 2124 DNA Homo sapiens MMP9 XM009491 110 atgagcctct ggcagcccct ggtcctggtg cccagacagc gccagtccac ccttgtgctc gacaggcagc tggcagagga atacctgtac ctcctggtgc tgggctgctg ctttgctgcc 60 ttccctggag acctgagaac caatctcacc 120 cgctatggtt acactcgggt ggcagagatg 180 cgtggagagt cgaaatctct ggggcctgcg ctgctgcttc tccagaagca actgtccctg 240 cccgagaccg gtgagctgga tagcgccacg ctgaaggcca tgcgaacccc acggtgcggg 300 gtcccagacc tgggcagatt ccaaaccttt gagggcgacc tcaagtggca ccaccacaac 360 atcacctatt ggatccaaaa ctactcggaa gacttgccgc gggcggtgat tgacgacgcc 420 tttgcccgcg ccttcgcact gtggagcgcg gtgacgccgc tcaccttcac tcgcgtgtac 480 agccgggacg cagacatcgt catccagttt ggtgtcgcgg agcacggaga cgggtatccc 540 ttcgacggga aggacgggct cctggcacac gcctttcctc ctggccccgg cattcaggga 600 gacgcccatt tcgacgatga cgagttgtgg tccctgggca agggcgtcgt ggttccaact 660 cggtttggaa acgcagatgg cgcggcctgc cacttcccct tcatcttcga gggccgctcc 720 tactctgcct gcaccaccga cggtcgctcc gacggcttgc cctggtgcag taccacggcc 780 aactacgaca ccgacgaccg gtttggcttc tgccccagcg agagactcta cacccaggac 840 ggcaatgctg atgggaaacc ctgccagttt ccattcatct tccaaggcca atcctactcc 900 gcctgcacca cggacggtcg ctccgacggc taccgctggt gcgccaccac cgccaactac 960 gaccgggaca agctcttcgg cttctgcccg acccgagctg actcgacggt gatggggggc 1020 aactcggcgg gggagctgtg cgtcttcccc ttcactttcc tgggtaagga gtactcgacc 1080 tgtaccagcg agggccgcgg agatgggcgc ctctggtgcg ctaccacctc gaactttgac 1140 agcgacaaga agtggggctt ctgcccggac caaggataca gtttgttcct cgtggcggcg 1200 catgagttcg gccacgcgct gggcttagat cattcctcag tgccggaggc gctcatgtac 1260 cctatgtacc gcttcactga ggggcccccc ttgcataagg acgacgtgaa tggcatccgg 1320 cacctctatg gtcctcgccc tgaacctgag ccacggcctc caaccaccac cacaccgcag 1380 cccacggctc ccccgacggt ctgccccacc ggacccccca ctgtccaccc ctcagagcgc 1440 cccacagctg gccccacagg tcccccctca gctggcccca caggtccccc cactgctggc 1500 ccttctacgg ccactactgt gcctttgagt ccggtggacg atgcctgcaa cgtgaacatc 1560 ttcgacgcca tcgcggagat tgggaaccag ctgtatttgt tcaaggatgg gaagtactgg 1620 cgattctctg agggcagggg gagccggccg cagggcccct tccttatcgc cgacaagtgg 1680 cccgcgctgc cccgcaagct ggactcggtc tttgaggagc ggctctccaa gaagcttttc 1740 ttcttctctg ggcgccaggt gtgggtgtac acaggcgcgt cggtgctggg cccgaggcgt 1800 ctggacaagc tgggcctggg agccgacgtg gcccaggtga ccggggccct ccggagtggc 1860 agggggaaga tgctgctgtt cagcgggcgg cgcctctgga ggttcgacgt gaaggcgcag 1920 atggtggatc cccggagcgc cagcgaggtg gaccggatgt tccccggggt gcctttggac 1980 acgcacgacg tcttccagta ccgagagaaa gcctatttct gccaggaccg cttctactgg 2040 cgcgtgagtt cccggagtga gttgaaccag gtggaccaag tgggctacgt gacctatgac 2100 atcctgcagt gccctgagga ctag 2124 111 2019 DNA Homo sapiens PKC alpha NM002737 111 atggctgacg ttttcccggg caacgactcc acggcgtctc aggacgtggc caaccgcttc 60 gcccgcaaag gggcgctgag gcagaagaac gtgcacgagg tgaaggacca caaattcatc 120 gcgcgcttct tcaagcagcc caccttctgc agccactgca ccgacttcat ctgggggttt 180 gggaaacaag gcttccagtg ccaagtttgc tgttttgtgg tccacaagag gtgccatgaa 240 tttgttactt tttcttgtcc gggtgcggat aagggacccg acactgatga ccccaggagc 300 aagcacaagt tcaaaatcca cacttacgga agccccacct tctgcgatca ctgtgggtca 360 ctgctctatg gacttatcca tcaagggatg aaatgtgaca cctgcgatat gaacgttcac 420 aagcaatgcg tcatcaatgt ccccagcctc tgcggaatgg atcacactga gaagaggggg 480 cggatttacc taaaggctga ggttgctgat gaaaagctcc atgtcacagt acgagatgca 540 aaaaatctaa tccctatgga tccaaacggg ctttcagatc cttatgtgaa gctgaaactt 600 attcctgatc ccaagaatga aagcaagcaa aaaaccaaaa ccatccgctc cacactaaat 660 ccgcagtgga atgagtcctt tacattcaaa ttgaaacctt cagacaaaga ccgacgactg 720 tctgtagaaa tctgggactg ggatcgaaca acaaggaatg acttcatggg atccctttcc 780 tttggagttt cggagctgat gaagatgccg gccagtggat ggtacaagtt gcttaaccaa 840 gaagaaggtg agtactacaa cgtacccatt ccggaagggg acgaggaagg aaacatggaa 900 ctcaggcaga aattcgagaa agccaaactt ggccctgctg gcaacaaagt catcagtccc 960 tctgaagaca ggaaacaacc ttccaacaac cttgaccgag tgaaactcac ggacttcaat 1020 ttcctcatgg tgttgggaaa ggggagtttt ggaaaggtga tgcttgccga caggaagggc 1080 acagaagaac tgtatgcaat caaaatcctg aagaaggatg tggtgattca ggatgatgac 1140 gtggagtgca ccatggtaga aaagcgagtc ttggccctgc ttgacaaacc cccgttcttg 1200 acgcagctgc actcctgctt ccagacagtg gatcggctgt acttcgtcat ggaatatgtc 1260 aacggtgggg acctcatgta ccacattcag caagtaggaa aatttaagga accacaagca 1320 gtattctatg cggcagagat ttccatcgga ttgttctttc ttcataaaag aggaatcatt 1380 tatagggatc tgaagttaga taacgtcatg ttggattcag aaggacatat caaaattgct 1440 gactttggga tgtgcaagga acacatgatg gatggagtca cgaccaggac cttctgtggg 1500 actccagatt atatcgcccc agagataatc gcttatcagc cgtatggaaa atctgtggac 1560 tggtgggcct atggcgtcct gttgtatgaa atgcttgccg ggcagcctcc atttgatggt 1620 gaagatgaag acgagctatt tcagtctatc atggagcaca acgtttccta tccaaaatcc 1680 ttgtccaagg aggctgtttc tatctgcaaa ggactgatga ccaaacaccc agccaagcgg 1740 ctgggctgtg ggcctgaggg ggagagggac gtgagagagc atgccttctt ccggaggatc 1800 gactgggaaa aactggagaa cagggagatc cagccaccat tcaagcccaa agtgtgtggc 1860 aaaggagcag agaactttga caagttcttc acacgaggac agcccgtctt aacaccacct 1920 gatcagctgg ttattgctaa catagaccag tctgattttg aagggttctc gtatgtcaac 1980 ccccagtttg tgcaccccat cttacagagt gcagtatga 2019 112 2022 DNA Homo sapiens PKC beta X07109 112 atggctgacc cggctgcggg gccgccgccg agcgagggcg aggagagcac cgtgcgcttc 60 gcccgcaaag gcgccctccg gcagaagaac gtgcatgagg tcaagaacca caaattcacc 120 gcccgcttct tcaagcagcc caccttctgc agccactgca ccgacttcat ctggggcttc 180 gggaagcagg gattccagtg ccaagtttgc tgctttgtgg tgcacaagcg gtgccatgaa 240 tttgtcacat tctcctgccc tggcgctgac aagggtccag cctccgatga cccccgcagc 300 aaacacaagt ttaagatcca cacgtactcc agccccacgt tttgtgacca ctgtgggtca 360 ctgctgtatg gactcatcca ccaggggatg aaatgtgaca cctgcatgat gaatgtgcac 420 aagcgctgcg tgatgaatgt tcccagcctg tgtggcacgg accacacgga gcgccgcggc 480 cgcatctaca tccaggccca catcgacagg gacgtcctca ttgtcctcgt aagagatgct 540 aaaaaccttg tacctatgga ccccaatggc ctgtcagatc cctacgtaaa actgaaactg 600 attcccgatc ccaaaagtga gagcaaacag aagaccaaaa ccatcaaatg ctccctcaac 660 cctgagtgga atgagacatt tagatttcag ctgaaagaat cggacaaaga cagaagactg 720 tcagtagaga tttgggattg ggatttgacc agcaggaatg acttcatggg atctttgtcc 780 tttgggattt ctgaacttca gaaggccagt gttgatggct ggtttaagtt actgagccag 840 gaggaaggcg agtacttcaa tgtgcctgtg ccaccagaag gaagtgaggc caatgaagaa 900 ctgcggcaga aatttgagag ggccaagatc agtcagggaa ccaaggtccc ggaagaaaag 960 acgaccaaca ctgtctccaa atttgacaac aatggcaaca gagaccggat gaaactgacc 1020 gattttaact tcctaatggt gctggggaaa ggcagctttg gcaaggtcat gctttcagaa 1080 cgaaaaggca cagatgagct ctatgctgtg aagatcctga agaaggacgt tgtgatccaa 1140 gatgatgacg tggagtgcac tatggtggag aagcgggtgt tggccctgcc tgggaagccg 1200 cccttcctga cccagctcca ctcctgcttc cagaccatgg accgcctgta ctttgtgatg 1260 gagtacgtga atgggggcga cctcatgtat cacatccagc aagtcggccg gttcaaggag 1320 ccccatgctg tattttacgc tgcagaaatt gccatcggtc tgttcttctt acagagtaag 1380 ggcatcattt accgtgacct aaaacttgac aacgtgatgc tcgattctga gggacacatc 1440 aagattgccg attttggcat gtgtaaggaa aacatctggg atggggtgac aaccaagaca 1500 ttctgtggca ctccagacta catcgccccc gagataattg cttatcagcc ctatgggaag 1560 tccgtggatt ggtgggcatt tggagtcctg ctgtatgaaa tgttggctgg gcaggcaccc 1620 tttgaagggg aggatgaaga tgaactcttc caatccatca tggaacacaa cgtagcctat 1680 cccaagtcta tgtccaagga agctgtggcc atctgcaaag ggctgatgac caaacaccca 1740 ggcaaacgtc tgggttgtgg acctgaaggc gaacgtgata tcaaagagca tgcatttttc 1800 cggtatattg attgggagaa acttgaacgc aaagagatcc agccccctta taagccaaaa 1860 gcttgtgggc gaaatgctga aaacttcgac cgatttttca cccgccatcc accagtccta 1920 acacctcccg accaggaagt catcaggaat attgaccaat cagaattcga aggattttcc 1980 tttgttaact ctgaattttt aaaacccgaa gtcaagagct aa 2022 113 2031 DNA Homo sapiens PKC delta NM006254 113 atggcgccgt tcctgcgcat cgccttcaac tcctatgagc tgggctccct gcaggccgag 60 gacgaggcga accagccctt ctgtgccgtg aagatgaagg aggcgctcag cacagagcgt 120 gggaaaacac tggtgcagaa gaagccgacc atgtatcctg agtggaagtc gacgttcgat 180 gcccacatct atgaggggcg cgtcatccag attgtgctaa tgcgggcagc agaggagcca 240 gtgtctgagg tgaccgtggg tgtgtcggtg ctggccgagc gctgcaagaa gaacaatggc 300 aaggctgagt tctggctgga cctgcagcct caggccaagg tgttgatgtc tgttcagtat 360 ttcctggagg acgtggattg caaacaatct atgcgcagtg aggacgaggc caagttccca 420 acgatgaacc gccgcggagc catcaaacag gccaaaatcc actacatcaa gaaccatgag 480 tttatcgcca ccttctttgg gcaacccacc ttctgttctg tgtgcaaaga ctttgtctgg 540 ggcctcaaca agcaaggcta caaatgcagg caatgtaacg ctgccatcca caagaaatgc 600 atcgacaaga tcatcggcag atgcactggc accgcggcca acagccggga cactatattc 660 cagaaagaac gcttcaacat cgacatgccg caccgcttca aggttcacaa ctacatgagc 720 cccaccttct gtgaccactg cggcagcctg ctctggggac tggtgaagca gggattaaag 780 tgtgaagact gcggcatgaa tgtgcaccat aaatgccggg agaaggtggc caacctctgc 840 ggcatcaacc agaagctttt ggctgaggcc ttgaaccaag tcacccagag agcctcccgg 900 agatcagact cagcctcctc agagcctgtt gggatatatc agggtttcga gaagaagacc 960 ggagttgctg gggaggacat gcaagacaac agtgggacct acggcaagat ctgggagggc 1020 agcagcaagt gcaacatcaa caacttcatc ttccacaagg tcctgggcaa aggcagcttc 1080 gggaaggtgc tgcttggaga gctgaagggc agaggagagt actctgccat caaggccctc 1140 aagaaggatg tggtcctgat cgacgacgac gtggagtgca ccatggttga gaagcgggtg 1200 ctgacacttg ccgcagagaa tccctttctc acccacctca tctgcacctt ccagaccaag 1260 gaccacctgt tctttgtgat ggagttcctc aacggggggg acctgatgta ccacatccag 1320 gacaaaggcc gctttgaact ctaccgtgcc acgttttatg ccgctgagat aatgtgtgga 1380 ctgcagtttc tacacagcaa gggcatcatt tacagggacc tcaaactgga caatgtgctg 1440 ttggaccggg atggccacat caagattgcc gactttggga tgtgcaaaga gaacatattc 1500 ggggagagcc gggccagcac cttctgcggc acccctgact atatcgcccc tgagatccta 1560 cagggcctga agtacacatt ctctgtggac tggtggtctt teggggtect tctgtacgag 1620 atgctcattg gccagtcccc cttccatggt gatgatgagg atgaactctt cgagtccatc 1680 cgtgtggaca cgccacatta tccccgctgg atcaccaagg agtccaagga catcctggag 1740 aagctctttg aaagggaacc aaccaagagg ctgggaatga cgggaaacat caaaatccac 1800 cccttcttca agaccataaa ctggactctg ctggaaaagc ggaggttgga gccacccttc 1860 aggcccaaag tgaagtcacc cagagactac agtaactttg accaggagtt cctgaacgag 1920 aaggcgcgcc tctcctacag cgacaagaac ctcatcgact ccatggacca gtctgcattc 1980 gctggcttct cctttgtgaa ccccaaa.ttc gagcacctcc tggaagattg a 2031 114 2049 DNA Homo sapiens PKC eta NM006255 114 atgtcgtctg gcaccatgaa gttcaatggc tatttgaggg tccgcatcgg tgaggcagtg 60 gggctgcagc ccacccgctg gtccctgcgc cactcgctct tcaagaaggg ccaccagctg 120 ctggacccct atctgacggt gagcgtggac caggtgcgcg tgggccagac cagcaccaag 180 cagaagacca acaaacccac gtacaacgag gagttttgcg ctaacgtcac cgacggcggc 240 cacctcgagt tggccgtctt ccacgagacc cccctgggct acgacttcgt ggccaactgc 300 accctgcagt tccaggagct cgtcggcacg accggcgcct cggacacctt cgagggttgg 360 gtggatctcg agccagaggg gaaagtattt gtggtaataa cccttaccgg gagtttcact 420 gaagctactc tccagagaga ccggatcttc aaacatttta ccaggaagcg ccaaagggct 480 atgcgaaggc gagtccacca gatcaatgga cacaagttca tggccacgta tctgaggcag 540 cccacctact gctctcactg cagggagttt atctggggag tgtttgggaa acagggttat 600 cagtgccaag tgtgcacctg tgtcgtccat aaacgctgcc atcatctaat tgttacagcc 660 tgtacttgcc aaaacaatat taacaaagtg gattcaaaga ttgcagaaca gaggttcggg 720 atcaacatcc cacacaagtt cagcatccac aactacaaag tgccaacatt ctgcgatcac 780 tgtggctcac tgctctgggg aataatgcga caaggacttc agtgtaaaat atgtaaaatg 840 aatgtgcata ttcgatgtca agcgaacgtg gcccctaact gtggggtaaa tgcggtggaa 900 cttgccaaga ccctggcagg gatgggtctc caacccggaa atatttctcc aacctcgaaa 960 ctcgtttcca gatcgaccct aagacgacag ggaaaggaga gcagcaaaga aggaaatggg 1020 attggggtta attcttccaa ccgacttggt atcgacaact ttgagttcat ccgagtgttg 1080 gggaagggga gttttgggaa ggtgatgctt gcaagagtaa aagaaacagg agacctctat 1140 gctgtgaagg tgctgaagaa ggacgtgatt ctgctggatg atgatgtgga atgcaccatg 1200 accgagaaaa ggatcctgtc tctggcccgc aatcacccct tcctcactca gttgttctgc 1260 tgctttcaga cccccgatcg tctgtttttt gtgatggagt ttgtgaatgg gggtgacttg 1320 atgttccaca ttcagaagtc tcgtcgtttt gatgaagcac gagctcgctt ctatgctgca 1380 gaaatcattt cggctctcat gttcctccat gataaaggaa tcatctatag agatctgaaa 1440 ctggacaatg tcctgttgga ccacgagggt cactgtaaac tggcagactt cggaatgtgc 1500 aaggagggga tttgcaatgg tgtcaccacg gccacattct gtggcacgcc agactatatc 1560 gctccagaga tcctccagga aatgctgtac gggcctgcag tagactggtg ggcaatgggc 1620 gtgttgctct atgagatgct ctgtggtcac gcgccttttg aggcagagaa tgaagatgac 1680 ctctttgagg ccatactgaa tgatgaggtg gtctacccta cctggctcca tgaagatgcc 1740 acagggatcc taaaatcttt catgaccaag aaccccacca tgcgcttggg cagcctgact 1800 cagggaggcg agcacgccat cttgagacat ccttttttta aggaaatcga ctgggcccag 1860 ctgaaccatc gccaaataga accgcctttc agacccagaa tcaaatcccg agaagatgtc 1920 agtaattttg accctgactt cataaaggaa gagccagttt taactccaat tgatgaggga 1980 catcttccaa tgattaacca ggatgagttt agaaactttt cctatgtgtc tccagaattg 2040 caaccatag 2049 115 948 DNA Homo sapiens PKC epsilon XM002370 115 atgttggcag aactcaaggg caaagatgaa gtatatgctg tgaaggtctt aaagaaggac 60 gtcatccttc aggatgatga cgtggactgc acaatgacag agaagaggat tttggctctg 120 gcacggaaac acccgtacct tacccaactc tactgctgct tccagaccaa ggaccgcctc 180 tttttcgtca tggaatatgt aaatggtgga gacctcatgt ttcagattca gcgctcccga 240 aaattcgacg agcctcgttc acggttctat gctgcagagg tcacatcggc cctcatgttc 300 ctccaccagc atggagtcat ctacagggat ttgaaactgg acaacatcct tctggatgca 360 gaaggtcact gcaagctggc tgacttcggg atgtgcaagg aagggattct gaatggtgtg 420 acgaccacca cgttctgtgg gactcctgac tacatagctc ctgagatcct gcaggagttg 480 gagtatggcc cctccgtgga ctggtgggcc ctgggggtgc tgatgtacga gatgatggct 540 ggacagcctc cctttgaggc cgacaatgag gacgacctat ttgagtccat cctccatgac 600 gacgtgctgt acccagtctg gctcagcaag gaggctgtca gcatcttgaa agctttcatg 660 acgaagaatc cccacaagcg cctgggctgt gtggcatcgc agaatggcga ggacgccatc 720 aagcagcacc cattcttcaa agagattgac tgggtgctcc tggagcagaa gaagatcaag 780 ccacccttca aaccacgcat taaaaccaaa agagacgtca ataattttga ccaagacttt 840 acccgggaag agccggtact cacccttgtg gacgaagcaa ttgtaaagca gatcaaccag 900 gaggaattca aaggtttctc ctactttggt gaagacctga tgccctga 948 116 1764 DNA Homo sapiens PKC iota NM002740 116 atgtcccaca cggtcgcagg cggcggcagc gcctactacc gcggggatat catgataaca ctttgcaatg aggttcgaga catgtgttct tggatagatg aggaaggaga cccgtgtaca tttagacttt atgagctaaa caaggattct ccagaacgtc ctgggatgcc ttgtccagga cgccgctgga gaaagcttta ttgtgccaat aggcgtgctc actgtgccat ctgcacagac aagtgcatca actgcaaact cttggttcat tgtgggcggc attctttgcc acaggaacca tctgaccatg cacagacagt aattccatat gttggtgaag aaaaagaggc aatgaacacc ggtcttcagg attttgattt gctccgggta ttggttcgat taaaaaaaac agatcgtatt gttaatgatg atgaggatat tgattgggta tccaatcatc ctttccttgt tgggctgcat tttgttatag agtatgtaaa tggaggagac cttcctgaag aacatgccag attttactct catgagcgag ggataattta tagagatttg ggccacatta aactcactga ctacggcatg accagcactt tctgtggtac tcctaattac tatggtttca gtgttgactg gtgggctctt aggtctccat ttgatattgt tgggagctcc ctcttccaag ttattttgga aaaacaaatt gcaagtgttc tgaagagttt tcttaataag caaacaggat ttgctgatat tcagggacac atggagcaaa aacaggtggt acctcccttt ggggaccatt cccaccaggt ccgggtgaaa 60 cattttgaac cttccatctc ctttgagggc 120 tttgacaacg aacagctctt caccatgaaa 180 gtatcatctc agttggagtt agaagaagcc 240 gaactcttga ttcatgtgtt cccttgtgta 300 gaagataaat ccatctaccg tagaggtgca 360 ggccacactt tccaagccaa gcgtttcaac 420 cgaatatggg gacttggacg ccaaggatat 480 aagaagtgcc ataaactcgt cacaattgaa 540 gtgatgccca tggatcagtc atccatgcat 600 aatccttcaa gtcatgagag tttggatcaa 660 agggaaagtg gcaaagcttc atccagtcta 720 ataggaagag gaagttatgc caaagtactg 780 tatgcaatga aagttgtgaa aaaagagctt 840 cagacagaga agcatgtgtt tgagcaggca 900 tcttgctttc agacagaaag cagattgttc 960 ctaatgtttc atatgcagcg acaaagaaaa 1020 gcagaaatca gtctagcatt aaattatctt 1080 aaactggaca atgtattact ggactctgaa 1140 tgtaaggaag gattacggcc aggagataca 1200 attgctcctg aaattttaag aggagaagat 1260 ggagtgctca tgtttgagat gatggcagga 1320 gataaccctg accagaacac agaggattat 1380 cgcataccac gttctctgtc tgtaaaagct 1440 gaccctaagg aacgattggg ttgtcatcct 1500 ccgttcttcc gaaatgttga ttgggatatg 1560 aaaccaaata tttctgggga atttggtttg 1620 gacaactttg attctcagtt tactaatgaa cctgtccagc tcactccaga tgacgatgac 1680 attgtgagga agattgatca gtctgaattt gaaggttttg agtatatcaa tcctcttttg 1740 atgtctgcag aagaatgtgt ctga 1764 117 2451 DNA Homo sapiens PKC mu XM007234 117 atgtatgata agatcctgct ttttcgccat gaccctacct ctgaaaacat gtgaaagcgg ccagtgatat ccaggaaggc gatcttattg aagtggtctt gccacctttg aagactttca gattcgtccc cacgctctct ttgttcattc ccagctttct gtgatcactg tggagaaatg ctgtgggggc tggtacgtca tgtgaagggt gtggtctgaa ttaccataag agatgtgcat ttaaaatacc agcggtgtga ggcggagaag gctctcaaac gtttccctca ctggggtcag acatcatctg ctgaactctc tacaagtgcc cctgatgagc cccttctgca tcagagtcgt ttattggtcg agagaagagg tcaaattctc aatcatacat attcaccttg acaagatttt gatgtctaaa gttaaagtgc cgcacacatt tcctacaccc ggcccacagt gtgccagtac tgcaagaagc ttctgaaggg cagggcttgc agtgcaaaga ttgcagattc aactgccata aacgttgtgc ccaaacaact gccttggcga agtgaccatt aatggagatt tgcttagccc tctgatgtgg tcatggaaga agggagtgat gacaatgata gtgaaaggaa atggatgata tggaagaagc aatggtccaa gatgcagaga tggcaatggc aacgacagtg gcgagatgca agatccagac ccagaccacg aggacgccaa agtccatcaa caagcaacaa tatcccactc atgagggtag tgcagtctgt aagaggaaaa gcagcacagt catgaaagaa ggatggatgg tccactacac acgctgcgga aacggcacta ttggagattg gatagcaaat gtattaccct ccttcagctg 60 gtcagcttcc 120 atacagagct 180 aggtcttaaa 240 caacaattgc 300 caccatccgc 360 aaaatcacca 420 tggacgacca 480 tgtcatccac 540 gcttttcagg 600 accgaaagta 660 tggggcagag 720 cagtgggctc 780 agagtgccag 840 cagaaccatc 900 caaacacacg 960 cagcaaggac 1020 ctttcagaat 1080 gacacaggaa gcaggtacta caaggaaatt cctttatctg aaattttgtc tctggaacca 1140 gtaaaaactt cagctttaat tcctaatggg gccaatcctc attgtttcga aatcactacg 1200 gcaaatgtag tgtattatgt gggagaaaat gtggtcaatc cttccagccc atcaccaaat 1260 aacagtgttc tcaccagtgg cgttggtgca gatgtggcca ggatgtggga gatagccatc 1320 cagcatgccc ttatgcccgt cattcccaag ggctcctccg tgggtacagg aaccaacttg 1380 cacagagata tctctgtgag tatttcagta tcaaattgcc agattcaaga aaatgtggac 1440 atcagcacag tatatcagat ttttcctgat gaagtactgg gttctggaca gtttggaatt 1500 gtttatggag gaaaacatcg taaaacagga agagatgtag ctattaaaat cattgacaaa 1560 ttacgatttc caacaaaaca agaaagccag cttcgtaatg aggttgcaat tctacagaac 1620 cttcatcacc ctggtgttgt aaatttggag tgtatgtttg agacgcctga aagagtgttt 1680 gttgttatgg aaaaactcca tggagacatg ctggaaatga tcttgtcaag tgaaaagggc 1740 aggttgccag agcacataac gaagttttta attactcaga tactcgtggc tttgcggcac 1800 cttcatttta aaaatatcgt tcactgtgac ctcaaaccag aaaatgtgtt gctagcctca 1860 gctgatcctt ttcctcaggt gaaactttgt gattttggtt ttgcccggat cattggagag 1920 aagtctttcc ggaggtcagt ggtgggtacc cccgcttacc tggctcctga ggtcctaagg 1980 aacaagggct acaatcgctc tctagacatg tggtctgttg gggtcatcat ctatgtaagc 2040 ctaagcggca cattcccatt taatgaagat gaagacatac acgaccaaat tcagaatgca 2100 gctttcatgt atccaccaaa tccctggaag gaaatatctc atgaagccat tgatcttatc 2160 aacaatttgc tgcaagtaaa aatgagaaag cgctacagtg tggataagac cttgagccac 2220 ccttggctac aggactatca gacctggtta gatttgcgag agctggaatg caaaatcggg 2280 gagcgctaca tcacccatga aagtgatgac ctgaggtggg agaagtatgc aggcgagcag 2340 gggctgcagt accccacaca cctgatcaat ccaagtgcta gccacagtga cactcctgag 2400 actgaagaaa cagaaatgaa agccctcggt gagcgtgtca gcatcctatg a 2451 118 2673 DNA Homo sapiens PKC nu NM005813 118 atgtctgcaa ataattcccc tccatcagcc cagaagtctg tattacccac agctattcct 60 gctgtgcttc cagctgcttc tccgtgttca agtcctaaga cgggactctc tgcccgactc 120 tctaatggaa gcttcagtgc accatcactc accaactcca gaggctcagt gcatacagtt 180 tcatttctac tgcaaattgg cctcacacgg gagagtgtta ccattgaagc ccaggaactg 240 tctttatctg ctgtcaagga tcttgtgtgc tccatagttt atcaaaagtt tccagagtgt 300 ggattctttg gcatgtatga caaaattctt ctctttcgcc atgacatgaa ctcagaaaac 360 attttgcagc tgattacctc agcagatgaa atacatgaag gagacctagt ggaagtggtt 420 ctttcagctt tagccacagt agaagacttc cagattcgtc cacatactct ctatgtacat 480 tcttacaaag ctcctacttt ctgtgattac tgtggtgaga tgctgtgggg attggtacgt 540 caaggactga aatgtgaagg ctgtggatta aattaccata aacgatgtgc cttcaagatt 600 ccaaataact gtagtggagt aagaaagaga cgtctgtcaa atgtatcttt accaggaccc 660 ggcctctcag ttccaagacc cctacagcct gaatatgtag cccttcccag tgaagagtca 720 catgtccacc aggaaccaag taagagaatt ccttcttgga gtggtcgccc aatctggatg 780 gaaaagatgg taatgtgcag agtgaaagtt ccacacacat ttgctgttca ctcttacacc 840 cgtcccacga tatgtcagta ctgcaagcgg ttactgaaag gcctctttcg ccaaggaatg 900 cagtgtaaag attgcaaatt caactgccat aaacgctgtg catcaaaagt accaagagac 960 tgccttggag aggttacttt caatggagaa ccttccagtc tgggaacaga tacagatata 1020 ccaatggata ttgacaataa tgacataaat agtgatagta gtcggggttt ggatgacaca 1080 gaagagccat cacccccaga agataagatg ttcttcttgg atccatctga tctcgatgtg 1140 gaaagagatg aagaagccgt taaaacaatc agtccatcaa caagcaataa tattccgcta 1200 atgagggttg tacaatccat caagcacaca aagaggaaga gcagcacaat ggtgaaggaa 1260 gggtggatgg tccattacac cagcagggat aacctgagaa agaggcatta ttggagactt 1320 gacagcaaat gtctaacatt atttcagaat gaatctggat caaagtatta taaggaaatt 1380 ccactttcag aaattctccg catatcttca ccacgagatt tcacaaacat ttcacaaggc 1440 agcaatccac actgttttga aatcattact gatactatgg tatacttcgt tggtgagaac 1500 aatggggaca gctctcataa tcctgttctt gctgccactg gagttggact tgatgtagca 1560 cagagctggg aaaaagcaat tcgccaagcc ctcatgcctg ttactcctca agcaagtgtt 1620 tgcacttctc cagggcaagg gaaagatcac aaagatttgt ctacaagtat ctctgtatct 1680 aattgtcaga ttcaggagaa tgtggatatc agtactgttt accagatett tgcagatgag 1740 gtgcttggtt caggccagtt tggcatcgtt tatggaggaa aacatagaaa gactgggagg 1800 gatgtggcta ttaaagtaat tgataagatg agattcccca caaaacaaga aagtcaactc 1860 cgtaatgaag tggctatttt acagaatttg caccatcctg ggattgtaaa cctggaatgt 1920 atgtttgaaa ccccagaacg agtctttgta gtaatggaaa agetgeatgg agatatgttg 1980 gaaatgattc tatccagtga gaaaagtcgg cttccagaac gaattactaa attcatggtc 2040 acacagatac ttgttgcttt gaggaatctg cattttaaga atattgtgca ctgtgattta 2100 aagccagaaa atgtgctgct tgcatcagca gagccatttc ctcaggtgaa gctgtgtgac 2160 tttggatttg cacgcatcat tggtgaaaag tcattcagga gatctgtggt aggaactcca 2220 gcatacttag cccctgaagt tctccggagc aaaggttaca accgttccct agatatgtgg 2280 teagtgggag ttatcatcta tgtgagcctc agtggcacat ttccttttaa tgaggatgaa 2340 gatataaatg accaaatcca aaatgctgca tttatgtacc caccaaatcc atggagagaa 2400 atttctggtg aagcaattga tctgataaac aatctgcttc aagtgaagat gagaaaacgt 2460 tacagtgttg acaaatctct tagtcatccc tggctacagg actatcagac ttggcttgac 2520 cttagagaat ttgaaactcg cattggagaa cgttacatta cacatgaaag tgatgatgct 2580 cgctgggaaa tacatgcata cacacataac cttgtatacc caaagcactt cattatggct 2640 cctaatccag atgatatgga agaagatcct taa 2673 119 2121 DNA Homo sapiens PKC tau NM006257 119 atgtcgccat ttctteggat tggcttgtcc aactttgact gcgggtcctg ccagtcttgt 60 cagggegagg ctgttaaccc ttactgtgct gtgetegtea aagagtatgt cgaatcagag 120 aacgggcaga tgtatatcca gaaaaagect accatgtacc caccctggga cagcactttt 180 gatgcccata tcaacaaggg aagagtcatg cagatcattg tgaaaggcaa aaacgtggac 240 ctcatctctg aaaccaccgt ggagctctac tcgctggctg agaggtgcag gaagaacaac 300 gggaagacag aaatatggtt agagctgaaa cctcaaggcc gaatgctaat gaatgcaaga 360 tactttctgg aaatgagtga cacaaaggac atgaatgaat ttgagacgga aggcttcttt 420 gctttgcatc agcgccgggg tgccatcaag caggcaaagg tccaccacgt caagtgccac 480 gagttcactg ccaccttctt cccacagccc acattttgct ctgtctgcca cgagtttgtc 540 tggggcctga acaaacaggg ctaccagtgc cgacaatgca atgcagcaat tcacaagaag 600 tgtattgata aagttatagc aaagtgcaca ggatcagcta tcaatagccg agaaaccatg 660 ttccacaagg agagattcaa aattgacatg ccacacagat ttaaagtcta caattacaag 720 agcccgacct tctgtgaaca ctgtgggacc ctgctgtggg gactggcacg gcaaggactc 780 aagtgtgatg catgtggcat gaatgtgcat catagatgcc agacaaaggt ggccaacctt 840 tgtggcataa accagaagct aatggctgaa gcgctggcca tgattgagag cactcaacag 900 gctcgctgct taagagatac tgaacagatc ttcagagaag gtccggttga aattggtctc 960 ccatgctcca tcaaaaatga agcaaggccg ccatgtttac cgacaccggg aaaaagagag 1020 cctcagggca tttcctggga gtctccgttg gatgaggtgg ataaaatgtg ccatcttcca 1080 gaacctgaac tgaacaaaga aagaccatct ctgcagatta aactaaaaat tgaggatttt 1140 atcttgcaca aaatgttggg gaaaggaagt tttggcaagg tcttcctggc agaattcaag 1200 aaaaccaatc aatttttcgc aataaaggcc ttaaagaaag atgtggtctt gatggacgat 1260 gatgttgagt gcacgatggt agagaagaga gttctttcct tggcctggga gcatccgttt 1320 ctgacgcaca tgttttgtac attccagacc aaggaaaacc tcttttttgt gatggagtac 1380 ctcaacggag gggacttaat gtaccacatc caaagctgcc acaagttcga cctttccaga 1440 gcgacgtttt atgctgctga aatcattctt ggtctgcagt tccttcattc caaaggaata 1500 gtctacaggg acctgaagct agataacatc ctgttagaca aagatggaca tatcaagatc 1560 gcggattttg gaatgtgcaa ggagaacatg ttaggagatg ccaagacgaa taccttctgt 1620 gggacacctg actacatcgc cccagagatc ttgctgggtc agaaatacaa ccactctgtg 1680 gactggtggt ccttcggggt tctcctttat gaaatgctga ttggtcagtc gcctttccac 1740 gggcaggatg aggaggagct cttccactcc atccgcatgg acaatccctt ttacccacgg 1800 tggctggaga aggaagcaaa ggaccttctg gtgaagctct tcgtgcgaga acctgagaag 1860 aggctgggcg tgaggggaga catccgccag caccctttgt ttcgggagat caactgggag 1920 gaacttgaac ggaaggagat tgacccaccg ttccggccga aagtgaaatc accatttgac 1980 tgcagcaatt tcgacaaaga attcttaaac gagaagcccc ggctgtcatt tgccgacaga 2040 gcactgatca acagcatgga ccagaatatg ttcaggaact tttccttcat gaaccccggg 2100 atggagcggc tgatatcctg a 2121 120 1779 DNA Homo sapiens PKC zeta NM2744 120 atgcccagca ggaccgaccc caagatggaa gggagcggcg gccgcgtccg cctcaaggcg 60 cattacgggg gggacatctt catcaccagc gtggacgccg ccacgacctt cgaggagctc 120 tgtgaggaag tgagagacat gtgtcgtctg caccagcagc acccgctcac cctcaagtgg 180 gtggacagcg aaggtgaccc ttgcacggtg tcctcccaga tggagctgga agaggctttc 240 cgcctggccc gtcagtgcag ggatgaaggc ctcatcattc atgttttccc gagcacccct 300 gagcagcctg gcctgccatg tagggagaa gacaaatcta tctaccgccg gggagccaga 360 agatggagga agctgtaccg tgccaacggc cacctcttcc aagccaagcg ctttaacagg 420 agagcgtact gcggtcagtg cagcgagagg atatggggcc tcgcgaggca aggctacagg 480 tgcatcaact gcaaactgct ggtccataag cgctgccacg gcctcgtccc gctgacctgc 540 aggaagcata tggattctgt catgccttcc caagagcctc cagtagacga caagaacgag 600 gacgccgacc ttccttccga ggagacagat ggaattgctt acatttcctc atcccggaag 660 catgacagca ttaaagacga ctcggaggac cttaagccag ttatcgatgg gatggatgga 720 atcaaaatct ctcaggggct tgggctgcag gactttgacc taatcagagt catcgggcgc 780 gggagctacg ccaaggttct cctggtgcgg ttgaagaaga atgaccaaat ttacgccatg 840 aaagtggtga agaaagagct ggtgcatgat gacgaggata ttgactgggt acagacagag 900 aagcacgtgt ttgagcaggc atccagcaac cccttcctgg tcggattaca ctcctgcttc 960 cagacgacaa gtcggttgtt cctggtcatt gagtacgtca acggcgggga cctgatgttc 1020 cacatgcaga ggcagaggaa gctccctgag gagcacgcca ggttctacgc ggccgagatc 1080 tgcatcgccc tcaacttcct gcacgagagg gggatcatct acagggacct gaagctggac 1140 aacgtcctcc tggatgcgga cgggcacatc aagctcacag actacggcat gtgcaaggaa 1200 ggcctgggcc ctggtgacac aacgagcact ttctgcggaa ccccgaatta catcgccccc 1260 gaaatcctgc ggggagagga gtacgggttc agcgtggact ggtgggcgct gggagtcctc 1320 atgtttgaga tgatggccgg gcgctccccg ttcgacatca tcaccgacaa cccggacatg 1380 aacacagagg actacctttt ccaagtgatc ctggagaagc ccatccggat cccccggttc 1440 ctgtccgtca aagcctccca tgttttaaaa ggatttttaa ataaggaccc caaagagagg 1500 ctcggctgcc ggccacagac tggattttct gacatcaagt cccacgcgtt cttccgcagc 1560 atagactggg acttgctgga gaagaagcag gcgctccctc cattccagcc acagatcaca 1620 gacgactacg gtctggacaa ctttgacaca cagttcacca gcgagcccgt gcagctgacc 1680 ccagacgatg aggatgccat aaagaggatc gaccagtcag agttcgaagg ctttgagtat 1740 atcaacccat tattgctgtc caccgaggag tcggtgtga 1779 121 576 DNA Homo sapiens VEGF NM003376 121 atgaactttc tgctgtcttg ggtgcattgg agccttgcct tgctgctcta cctccaccat 60 gccaagtggt cccaggctgc acccatggca gaaggaggag ggcagaatca tcacgaagtg 120 gtgaagttca tggatgtcta tcagcgcagc tactgccatc caatcgagac cctggtggac 180 atcttccagg agtaccctga tgagatcgag tacatcttca agccatcctg tgtgcccctg 240 atgcgatgcg ggggctgctg caatgacgag ggcctggagt gtgtgcccac tgaggagtcc 300 aacatcacca tgcagattat gcggatcaaa cctcaccaag gccagcacat aggagagatg 360 agcttcctac agcacaacaa atgtgaatgc agaccaaaga aagatagagc aagacaagaa 420 aatccctgtg ggccttgctc agagcggaga aagcatttgt ttgtacaaga tccgcagacg 480 tgtaaatgtt cctgcaaaaa cacagactcg cgttgcaagg cgaggcagct tgagttaaac 540 gaacgtactt gcagatgtga caagccgagg cggtga 576 122 624 DNA Homo sapiens VEGF B NM003377 122 atgagccctc tgctccgccg cctgctgctc gccgcactcc tgcagctggc ccccgcccag 60 gcccctgtct cccagcctga tgcccctggc caccagagga aagtggtgtc atggatagat 120 gtgtatactc gcgctacctg ccagccccgg gaggtggtgg tgcccttgac tgtggagctc 180 atgggcaccg tggecaaaca gctggtgccc agctgcgtga ctgtgcagcg ctgtggtggc 240 tgctgccctg acgatggcct ggagtgtgtg cccactgggc agcaccaagt ccggatgcag 300 atcctcatga tccggtaccc gagcagtcag ctgggggaga tgtccctgga agaacacagc 360 cagtgtgaat gcagacctaa aaaaaaggac agtgctgtga agecagacag ggctgccact 420 ccccaccacc gtccccagcc ccgttctgtt ccgggctggg actctgcccc cggagcaccc 480 tccccagctg acatcaccca tcccactcca gccccaggcc cctctgccca cgctgcaccc 540 agcaccacca gcgccctgac ccccggacct gccgccgccg ctgccgacgc cgcagcttcc 600 tccgttgcca agggegggge ttag 624 123 1260 DNA Home ) sapiens VEGF C NM005429 123 atgcacttgc tgggcttctt ctctgtggcg tgttctctgc tcgccgctgc gctgctcccg 60 ggtcctcgcg aggcgcccgc cgccgccgcc gccttcgagt ccggactcga cctctcggac 120 gcggagcccg acgcgggcga ggccacggct tatgcaagca aagatctgga ggagcagtta 180 cggtctgtgt ccagtgtaga tgaactcatg actgtactct acccagaata ttggaaaatg 240 tacaagtgtc agctaaggaa aggaggctgg caacataaca gagaacaggc caacctcaac 300 tcaaggacag aagagactat aaaatttgct gcagcacatt ataatacaga gatcttgaaa 360 agtattgata atgagtggag aaagactcaa tgcatgccac gggaggtgtg tatagatgtg 420 gggaaggagt ttggagtcgc gacaaacacc ttctttaaac ctccatgtgt gtccgtctac 480 agatgtgggg gttgctgcaa tagtgagggg ctgcagtgca tgaacaccag cacgagctac 540 ctcagcaaga cgttatttga aattacagtg cctctctctc aaggccccaa accagtaaca 600 atcagttttg ccaatcacac ttcctgccga tgcatgtcta aactggatgt ttacagacaa 660 gttcattcca ttattagacg ttccctgcca gcaacactac cacagtgtca ggcagcgaac 720 aagacctgcc ccaccaatta catgtggaat aatcacatct gcagatgcct ggctcaggaa 780 gattttatgt tttcctcgga tgctggagat gactcaacag atggattcca tgacatctgt 840 ggaccaaaca aggagctgga tgaagagacc tgtcagtgtg tctgcagagc ggggcttcgg 900 cctgccagct gtggacccca caaagaacta gacagaaact catgccagtg tgtctgtaaa 960 aacaaactct tccccagcca atgtggggcc aaccgagaat ttgatgaaaa cacatgccag 1020 tgtgtatgta aaagaacctg ccccagaaat caacccctaa atcctggaaa atgtgcctgt 1080 gaatgtacag aaagtccaca gaaatgcttg ttaaaaggaa agaagttcca ccaccaaaca 1140 tgcagctgtt acagacggcc atgtacgaac cgccagaagg cttgtgagcc aggattttca 1200 tatagtgaag aagtgtgtcg ttgtgtccct tcatattgga aaagaccaca aatgagctaa 1260 124 1074 DNA Homo sapiens VEGF D AJ000185 124 atattcaaaa tgtacagaga gtgggtagtg gtgaatgttt tcatgatgtt gtacgtccag 60 ctggtgcagg gctccagtaa tgaacatgga ccagtgaagc gatcatctca gtccacattg 120 gaacgatctg aacagcagat cagggctgct tctagtttgg aggaactact tcgaattact 180 cactctgagg actggaagct gtggagatgc aggctgaggc tcaaaagttt taccagtatg 240 gactctcgct cagcatccca tcggtccact aggtttgcgg. caactttcta tgacattgaa 300 acactaaaag ttatagatga agaatggcaa agaactcagt gcagccctag agaaacgtgc 360 gtggaggtgg ccagtgagct ggggaagagt accaacacat tcttcaagcc cccttgtgtg 420 aacgtgttcc gatgtggtgg ctgttgcaat gaagagagcc ttatctgtat gaacaccagc 480 acctcgtaca tttccaaaca gctctttgag atatcagtgc ctttgacatc agtacctgaa 540 ttagtgcctg ttaaagttgc caatcataca ggttgtaagt gcttgccaac agccccccgc 600 catccatact caattatcag aagatccatc cagatccctg aagaagatcg ctgttcccat 660 tccaagaaac tctgtcctat tgacatgcta tgggatagca acaaatgtaa atgtgttttg 720 caggaggaaa atccacttgc tggaacagaa gaccactctc atctccagga accagctctc 780 tgtgggccac acatgatgtt tgacgaagat cgttgcgagt gtgtctgtaa aacaccatgt 840 cccaaagatc taatccagca ccccaaaaac tgcagttgct ttgagtgcaa agaaagtctg 900 gagacctgct gccagaagca caagctattt cacccagaca cctgcagctg tgaggacaga 960 tgcccctttc ataccagacc atgtgcaagt ggcaaaacag catgtgcaaa gcattgccgc 1020 tttccaaagg agaaaagggc tgcccagggg ccccacagcc gaaagaatcc ttga 1074 125 1314 DNA Homo sapiens E2F M96577 125 atggccttgg ccggggcccc tgcgggcggc ccatgcgcgc cggcgctgga ggccctgctc 60 ggggccggcg CgCtgCggCt gctcgactcc tcgcagatcg tcatcatctc cgccgcgcag 120 gacgccagcg ccccgccggc tcccaccggc cccgcggcgc ccgccgccgg cccctgcgac 180 cctgacctgc tgctcttcgc cacaccgcag gcgccccggc ccacacccag tgcgccgcgg 240 cccgcgctcg gccgcccgcc ggtgaagcgg aggctggacc tggaaactga ccatcagtac 300 ctggccgaga gcagtgggcc agctcggggc agaggccgcc atccaggaaa aggtgtgaaa 360 tccccggggg agaagtcacg ctatgagacc tcactgaatc tgaccaccaa gcgcttcctg 420 gagctgctga gccactcggc tgacggtgtc gtcgacctga actgggctgc cgaggtgctg 480 aaggtgcaga agcggcgcat ctatgacatc accaacgtcc ttgagggcat ccagctcatt 540 gccaagaagt ccaagaacca catccagtgg ctgggcagcc acaccacagt gggcgtcggc 600 ggacggcttg aggggttgac ccaggacctc cgacagctgc aggagagcga gcagcagctg 660 gaccacctga tgaatatctg tactacgcag ctgcgcctgc tctccgagga cactgacagc 720 cagcgcctgg cctacgtgac gtgtcaggac cttcgtagca ttgcagaccc tgcagagcag 780 atggttatgg tgatcaaagc ccctcctgag acccagctcc aagccgtgga ctcttcggag 840 aactttcaga tctcccttaa gagcaaacaa ggcccgatcg atgttttcct gtgccctgag 900 gagaccgtag gtgggatcag ccctgggaag accccatccc aggaggtcac ttctgaggag 960 gagaacaggg ccactgactc tgccaccata gtgtcaccac caccatcatc tcccccctca 1020 tccctcacca cagatcccag ccagtctcta ctcagcctgg agcaagaacc gctgttgtcc 1080 cggatgggca gcctgcgggc tcccgtggac gaggaccgcc tgtccccgct ggtggcggcc 1140 gactcgctcc tggagcatgt gcgggaggac ttctccggcc tcctccctga ggagttcatc 1200 agcctttccc caccccacga ggccctcgac taccacttcg gcctcgagga gggcgagggc 1260 atcagagacc tcttcgactg tgactttggg gacctcaccc ccctggattt ctga 1314 126 166 DNA Human papillomavirus EBER-1 Jo2078 tagccacccg 60 cagactctgc 120 166 126 ggacctacgc tgccctagag gttttgctag ggaggagacg tgtgtggctg tcccgggtac aagtcccggg tggtgaggac ggtgtctgtg gttgtcttcc tttctgccgt cttcggtcaa gtaccagctg gtggtccgca tgtttt 127 172 DNA Hepatitis C virus EBER-2 J02078 127 ggacagccgt tgccctagtg gtttcggaca caccgccaac gctcagtgcg gtgctaccga 60 cccgaggtca agtcccgggg gaggagaaga gaggcttccc gcctagagca tttgcaagtc 120 aggattctct aatccctctg ggagaagggt attcggcttg tccgctattt tt 172 128 651 DNA Hepatitis C virus NS2 AJ238799 128 atggaccggg accttgtcac atcaccaggg cgcgatgccg aaaatcttgc ccgtacttcg gggggteatt tatgaccatc gcagttgagc accgcggcgt atacatctgg agatggcagc cgcactataa ccgaggcaca tcatcctcct tcgccatact tgcgcgcaca atgtccaaat tcaccccact ccgtcgtctt gtggggacat gaccggcaga atcgtgcgga gctgttcctc cttgcaagtg cacgtgcgcg cggtccactc cgggctcatt ggctctcatg gcgggactgg ctctgatatg catcttgggc cagccttgaa ggcgcggttt gctaggctca tggatccccc atccacccag atggtgctcc cgtgcatgca aagttggccg gcccacgcgg gagaccaagg ctgcccgtct gggcaggggt tcgtaggtct tatggtggtt ccctcaacgt agctaatctt aggctggtat tgctggtgcg cactgacagg gcctacgaga ttatcacctg ccgcccgcag ggcgactcct gatactcttg 60 acaatatttt 120 tcgggggggc 180 taccatcacc 240 aaccaaagtg 300 gaaggttgct 360 tacgtacgtt 420 ccttgcggtg 480 gggggcagac 540 ggggagggag 600 c 651 129 161 DNA Hepatitis C virus NS4A AJ238799 129 gcacctgggt gctggtaggc ggagtcctag cagctctggc cgcgtattgc ctgacaacag 60 gcagcgtggt cattgtgggc aggatcatct tgtccggaaa gccggccatc attcccgaca 120 gggaagtcct ttaccgggag ttcgatgaga tggaagagtg c 161 130 783 DNA Hepatitis C virus NS4B AJ238799 130 gcctcacacc tcccttacat cgaacaggga atgcagctcg ccgaacaatt caaacagaag 60 gcaatcgggt tgctgcaaac agccaccaag caagcggagg ctgctgctcc cgtggtggaa 120 tccaagtggc ggaccctcga agccttctgg gcgaagcata tgtggaattt catcagcggg 180 atacaatatt tagcaggctt gtccactctg cctggcaacc ccgcgatagc atcactgatg 240 gcattcacag cctctatcac cagcccgctc accacccaac ataccctcct gtttaacatc 300 ctggggggat gggtggccgc ccaacttgct cctcccagcg ctgcttctgc tttcgtaggc 360 gccggcatcg ctggagcggc tgttggcagc ataggccttg ggaaggtgct tgtggatatt 420 ttggcaggtt atggagcagg ggtggcaggc gcgctcgtgg cctttaaggt catgagcggc 480 gagatgccct ccaccgagga cctggttaac ctactccctg ctatcctctc ccctggcgcc 540 ctagtcgtcg gggtcgtgtg cgcagcgata ctgcgtcggc acgtgggccc aggggagggg 600 gctgtgcagt ggatgaaccg gctgatagcg ttcgcttcgc ggggtaacca cgtctccccc 660 acgcactatg tgcctgagag cgacgctgca gcacgtgtca ctcagatcct ctctagtctt 720 accatcactc agctgctgaa gaggcttcac cagtggatca acgaggactg ctccacgcca 780 tgc 783 131 1341 DNA Hepatitis C virus NS5A AJ238799 131 tccggctcgt ggctaagaga tgtttgggat tggatatgca cggtgttgac tgatttcaag 60 acctggctcc agtccaagct cctgccgcga ttgccgggag tccccttctt ctcatgtcaa 120 cgtgggtaca agggagtctg gcggggcgac ggcatcatgc aaaccacctg cccatgtgga 180 gcacagatca ccggacatgt gaaaaacggt tccatgagga tcgtggggcc taggacctgt 240 agtaacacgt ggcatggaac attccccatt aacgcgtaca ccacgggccc ctgcacgccc 300 tccccggcgc caaattattc tagggcgctg tggcgggtgg ctgctgagga gtacgtggag 360 gttacgcggg tgggggattt ccactacgtg acgggcatga ccactgacaa cgtaaagtgc 420 ccgtgtcagg ttccggcccc cgaattcttc acagaagtgg atggggtgcg gttgcacagg 480 tacgctccag cgtgcaaacc cctcctacgg gaggaggtca cattcctggt cgggctcaat 540 caatacctgg ttgggtcaca gctcccatgc gagcccgaac cggacgtagc agtgctcact 600 tccatgctca ccgacccctc ccacattacg gcggagacgg ctaagcgtag gctggccagg 660 ggatctcccc cctccttggc cagctcatca gctagccagc tgtctgcgcc ttccttgaag 720 gcaacatgca ctacccgtca tgactccccg gacgctgacc tcatcgaggc caacctcctg 780 tggcggcagg agatgggcgg gaacatcacc cgcgtggagt cagaaaataa ggtagtaatt 840 ttggactctt tcgagccgct ccaagcggag gaggatgaga gggaagtatc cgttccggcg 900 gagatcctgc ggaggtccag gaaattccct cgagcgatgc ccatatgggc acgcccggat 960 tacaaccctc cactgttaga gtcctggaag gacccggact acgtccctcc agtggtacac 1020 gggtgtccat tgccgcctgc caaggcccct ccgataccac ctccacggag gaagaggacg 1080 gttgtcctgt cagaatctac cgtgtcttct gccttggcgg agctcgccac aaagaccttc 1140 ggcagctccg aatcgtcggc cgtcgacagc ggcacggcaa cggcctctcc tgaccagccc 1200 tccgacgacg gcgacgcggg atccgacgtt gagtcgtact cctccatgcc cccccttgag 1260 ggggagccgg gggatcccga tctcagcgac gggtcttggt ctaccgtaag cgaggaggct 1320 agtgaggacg tcgtctgctg c 1341 132 1772 DNA Hepatitis C virus NS5B AJ238799 132 tcgatgtcct acacatggac aggcgccctg atcacgccat gcgctgcgga ggaaaccaag 60 ctgcccatca atgcactgag caactctttg ctccgtcacc acaacttggt ctatgctaca 120 acatctcgca gcgcaagcct gcggcagaag aaggtcacct ttgacagact gcaggtcctg 180 gacgaccact accgggacgt gctcaaggag atgaaggcga aggcgtccac agttaaggct 240 aaacttctat ccgtggagga agcctgtaag ctgacgcccc cacattcggc cagatctaaa 300 tttggctatg gggcaaagga cgtccggaac ctatccagca aggccgttaa ccacatccgc 360 tccgtgtgga aggacttgct ggaagacact gagacaccaa ttgacaccac catcatggca 420 aaaaatgagg ttttctgcgt ccaaccagag aaggggggcc gcaagccagc tcgccttatc 480 gtattcccag atttgggggt tegtgtgtgc gagaaaatgg ccctttacga tgtggtctcc 540 accctccctc aggccgtgat gggctcttca tacggattcc aatactctcc tggacagcgg 600 gtcgagttcc tggtgaatgc ctggaaagcg aagaaatgcc ctatgggctt cgcatatgac 660 acccgctgtt ttgactcaac ggtcactgag aatgacatcc gtgttgagga gtcaatctac 720 caatgttgtg acttggcccc cgaagccaga caggccataa ggtcgctcac agagcggctt 780 tacatcgggg gccccctgac taattctaaa gggcagaact gcggctatcg ccggtgccgc 840 gcgagcggtg tactgacgac cagctgcggt aataccctca catgttactt gaaggccgct 900 gcggcctgtc gagctgcgaa gctccaggac tgcacgatgc tcgtatgcgg agacgacctt 960 gtcgttatct gtgaaagcgc ggggacccaa gaggacgagg cgagcctacg ggccttcacg 1020 gaggctatga ctagatactc tgccccccct ggggacccgc ccaaaccaga atacgacttg 1080 gagttgataa catcatgctc ctccaatgtg tcagtcgcgc acgatgcatc tggcaaaagg 1140 gtgtactatc tcacccgtga ccccaccacc ccccttgcgc gggctgcgtg ggagacagct 1200 agacacactc cagtcaattc ctggctaggc aacatcatca tgtatgcgcc caccttgtgg 1260 gcaaggatga tcctgatgac tcatttcttc tccatccttc tagctcagga acaacttgaa 1320 aaagccctag attgtcagat ctacggggcc tgttactcca ttgagccact tgacctacct 1380 cagatcattc aacgactcca tggccttagc gcattttcac tccatagtta ctctccaggt 1440 gagatcaata gggtggcttc atgcctcagg aaacttgggg taccgccctt gcgagtctgg 1500 agacatcggg ccagaagtgt ccgcgctagg ctactgtccc agggggggag ggctgccact 1560 tgtggcaagt acctcttcaa ctgggcagta aggaccaagc tcaaactcac tccaatcccg 1620 gctgcgtccc agttggattt atccagctgg ttcgttgctg gttacagcgg gggagacata 1680 tatcacagcc tgtctcgtgc ccgaccccgc tggttcatgt ggtgcctact cctactttct 1740 gtaggggtag gcatctatct actccccaac eg 1772 133 1892 DNA Hepatitis C virus NS3 AJ238799 133 cgcctattac ggcctactcc caacagacgc gaggectact tggctgeate atcactagcc 60 tcacaggccg ggacaggaac caggtcgagg gggaggtcca agtggtctcc accgcaacac 120 aatctttcct ggcgacctgc gtcaatggcg tgtgttggac tgtctatcat ggtgccggct 180 caaagaccct tgccggccca aagggcccaa tcacccaaat gtacaccaat gtggaccagg 240 acctcgtcgg ctggcaagcg ccccccgggg cgcgttcctt gacaccatgc acctgcggca 300 gctcggacct ttacttggtc acgaggcatg ccgatgtcat tccggtgcgc eggeggggeg 360 acagcagggg gagcctactc tcccccaggc ccgtctccta cttgaagggc tettegggeg 420 gtccactgct ctgcccctcg gggcacgctg tgggcatctt tcgggctgcc gtgtgcaccc 480 gaggggttgc gaaggcggtg gactttgtac ccgtcgagtc tatggaaacc actatgeggt 540 ccccggtctt cacggacaac tcgtcccctc cggccgtacc gcagacattc caggtggccc 600 atctacacgc ccctactggt ageggcaaga gcactaaggt gccggctgcg tatgcagccc 660 aagggtataa ggtgcttgtc ctgaacccgt ccgtcgccgc caccctaggt ttcggggcgt 720 atatgtctaa ggcacatggt atcgacccta acatcagaac eggggtaagg accatcacca 780 cgggtgcccc catcacgtac tccacctatg gcaagtttct tgccgacggt ggttgctctg 840 ggggegecta tgacatcata atatgtgatg agtgccactc aactgactcg accactatcc 900 tgggcategg cacagtcctg gaecaagegg agaeggctgg agcgcgactc gtcgtgctcg 960 ccaccgctac gcctccggga tcggtcaccg tgccacatcc aaacatcgag gaggtggctc 1020 tgtccagcac tggagaaatc cccttttatg geaaagecat ccccatcgag accatcaagg 1080 gggggaggca cctcattttc tgccattcca agaagaaatg tgatgagctc gccgcgaagc 1140 tgtccggcct caactagcgg atttcgactc acccgacctt ggcgaggcag ggccctcggg ggtacgagct ggttgcccgt acatagacgc tagcatacca tgtggaagtg ggctgggagc catgcatgtc cggactcaat agacgtcatt agtgatcgac caccattgag gactggtagg catgttcgat cacgcccgcc ctgccaggac ccatttcttg ggctacggtg tctcatacgg cgttcaaaac ggctgacctg gctgtagcat gtcgtagcaa tgcaatacat acgacgaccg ggcaggatgg tcctcggttc gagacctcag catctggagt tcccagacta tgcgccaggg ctaaagccta gaggttacta gaggtcgtca attaccgggg cggacgctct gtgtcaccca tgccacaaga gcatttacag tgtgcgagtg ttaggttgcg tctgggagag agcaggcagg ctcaggctcc cgctgcacgg ccacacaccc cg ccttgatgta aatgacgggc gacagtcgac cgcggtgtca gtttgtgact ctatgacgcg ggcttaccta cgtctttaca agacaacttc acctccatcg gccaacgccc cataaccaaa tccgtcatac tttaccggcg ttcagcctgg cgctcgcagc ccaggagaac ggctgtgctt aacacaccag ggcctcaccc ccctacctgg tgggaccaaa ctgctgtata tacatcatgg 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1860 1892 134 822 DNA Homo sapiens stmn cell factor M59964 134 atgaagaaga cctctcgtca actaaattgg atggatgttt :tgactgatc itagacaaac laggatctaa cacaaacttg aaactgaagg tggcaaatct tgccaagtca ttctggacaa ttgtgaatat aaaaatcatt gattctcact gatctgcagg tccaaaagac ttgttggata gttttcaaat agtcgatgac caagagccca tgcatttatc aatcgtgtga tacatgataa agcgagatgg atttctgaag cttgtggagt gaacccaggc ttcagctgct ctaataatgt ccctcaaata tagtacaatt gcttgagtaa gcgtcaaaga tctttactcc cctatttaat 60 aaaagacgtc 120 tgtccccggg 180 gtcagacagc 240 ttattccatc 300 aaactcatct 360 tgaagaattc 420 tttagaattt ttaatagatc cattgatgcc ttcaaggact ttgtagtggc atctgaaact 480 agtgattgtg tggtttcttc aacattaagt cctgagaaag attccagagt cagtgtcaca 540 aaaccattta tgttaccccc tgttgcagcc agctccctta ggaatgacag cagtagcagt 600 aataggaagg ccaaaaatcc ccctggagac tccagcctac actgggcagc catggcattg 660 ccagcattgt tttctcttat aattggcttt gcttttggag ccttatactg gaagaagaga 720 cagccaagtc ttacaagggc agttgaaaat atacaaatta atgaagagga taatgagata 780 agtatgttgc aagagaaaga gagagagttt caagaagtgt aa 822 135 483 DNA Homo sapiens TGFalpha AF123238 135 atggtcccct cggctggaca gctcgccctg ttcgctctgg gtattgtgtt ggctgcgtgc 60 caggccttgg agaacagcac gtccccgctg agtgcagacc cgcccgtggc tgcagcagtg 120 gtgtcccatt ttaatgactg cccagattcc cacactcagt tctgcttcca tggaacctgc 180 aggtttttgg tgcaggagga caagccagca tgtgtctgcc attctgggta cgttggtgca 240 cgctgtgagc atgcggacct cctggccgtg gtggctgcca gccagaagaa gcaggccatc 300 accgccttgg tggtggtctc catcgtggcc ctggctgtcc ttatcatcac atgtgtgctg 360 atacactgct gccaggtccg aaaacactgt gagtggtgcc gggccctcat ctgccggcac 420 gagaagccca gcgccctcct gaagggaaga accgcttgct gccactcaga aacagtggtc 480 tga 483 136 1071 DNA Homo sapiens GD3 synthase NM003034 136 atgagcccct gcgggcgggc ccggcgacaa acgtccagag gggccatggc tgtactggcg 60 tggaagttcc cgcggacccg gctgcccatg ggagccagtg ccctctgtgt cgtggtcctc 120 tgttggctct acatcttccc cgtctaccgg ctgcccaacg agaaagagat cgtgcagggg 180 gtgctgcaac agggcacggc gtggaggagg aaccagaccg cggccagagc gttcaggaaa 240 caaatggaag actgctgcga ccctgcccat ctctttgcta tgactaaaat gaattcccct 300 atggggaaga gcatgtggta tgacggggag tttttatact cattcaccat tgacaattca 360 acttactctc tcttcccaca ggcaacccca ttccagctgc cattgaagaa atgcgcggtg 420 gtgggaaatg gtgggattct gaagaagagt ggctgtggcc gtcaaataga tgaagcaaat 480 tttgtcatgc gatgcaatct ccctcctttg tcaagtgaat acactaagga tgttggatcc 540 aaaagtcagt tagtgacagc taatcccagc ataattcggc aaaggtttca gaaccttctg 600 tggtccagaa agacatttgt ggacaacatg aaaatctata accacagtta catctacatg 660 cctgcctttt ctatgaagac aggaacagag ccatctttga gggtttatta tacactgtca 720 gatgttggtg ccaatcaaac agtgctgttt gccaacccca actttctgcg tagcattgga 780 aagttctgga aaagtagagg aatccatgcc aagcgcctgt ccacaggact ttttctggtg 840 agcgcagctc tgggtctctg tgaagaggtg gccatctatg gcttctggcc cttctctgtg 900 aatatgcatg agcagcccat cagccaccac tactatgaca acgtcttacc cttttctggc 960 ttccatgcca tgcccgagga atttctccaa ctctggtatc ttcataaaat cggtgcactg 1020 agaatgcagc tggacccatg tgaagatacc tcactccagc ccacttccta g 1071 137 744 DNA Homo sapiens FGF14 NM004115 137 atggccgcgg ccatcgctag cggcttgatc cgccagaagc ggcaggcgcg ggagcagcac 60 tgggaccggc cgtctgccag caggaggcgg agcagcccca gcaagaaccg cgggctctgc 120 aacggcaacc tggtggatat cttctccaaa gtgcgcatct tcggcctcaa gaagcgcagg 180 ttgcggcgcc aagatcccca gctcaagggt atagtgacca ggttatattg caggcaaggc 240 tactacttgc aaatgcaccc cgatggagct ctcgatggaa ccaaggatga cagcactaat 300 tctacactct tcaacctcat accagtggga ctacgtgttg ttgccatcca gggagtgaaa 360 acagggttgt atatagccat gaatggagaa ggttacctct acccatcaga actttttacc 420 cctgaatgca agtttaaaga atctgttttt gaaaattatt atgtaatcta ctcatccatg 480 ttgtacagac aacaggaatc tggtagagcc tggtttttgg gattaaataa ggaagggcaa 540 gctatgaaag ggaacagagt aaagaaaacc aaaccagcag ctcattttct acccaagcca 600 ttggaagttg ccatgtaccg agaaccatct ttgcatgatg ttggggaaac ggtcccgaag 660 cctggggtga cgccaagtaa aagcacaagt gcgtctgcaa taatgaatgg aggcaaacca 720 gtcaacaaga gtaagacaac atag 744 138 1503 DNA Human immunodeficiency virus gag (HIV) NC001802 138 atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg 60 ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag 120 ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata 180 ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat 240 acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct 300 ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct 360 gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg 420 caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa 480 gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc 540 ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg 600 ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca 660 gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact 720 agtacccttc aggaacaaat aggatggatg acaaataatc cacctatccc agtaggagaa 780 atttataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc 840 agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccggttc 900 tataaaactc taagagccga gcaagcttca caggaggtaa aaaattggat gacagaaacc 960 ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagcg 1020 gctacactag aagaaatgat gacagcatgt cagggagtag gaggacccgg ccataaggca 1080 agagttttgg ctgaagcaat gagccaagta acaaattcag ctaccataat gatgcagaga 1140 ggcaatttta ggaaccaaag aaagattgtt aagtgtttca attgtggcaa agaagggcac 1200 acagccagaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga 1260 caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc 1320 tacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa 1380 gagagcttca ggtctggggt agagacaaca actccccctc agaagcagga gccgatagac 1440 aaggaactgt atcctttaac ttccctcagg tcactctttg gcaacgaccc ctcgtcacaa 1500 taa 1503 139 1101 DNA Human immunodeficiency virus TARBP2 NM004178 139 atgagtgaag aggagcaagg ctccggcact accacgggct gcgggctgcc tagtatagag 60 caaatgctgg ccgccaaccc aggcaagacc ccgatcagcc ttctgcagga gtatgggacc 120 agaataggga agacgcctgt gtacgacctt ctcaaagccg agggccaagc ccaccagcct 180 aatttcacct tccgggtcac cgttggcgac accagctgca ctggtcaggg ccccagcaag 240 aaggcagcca agcacaaggc agctgaggtg gccctcaaac acctcaaagg ggggagcatg 300 ctggagccgg ccctggagga cagcagttct ttttctcccc tagactcttc actgcctgag 360 gacattccgg tttttactgc tgcagcagct gctaccccag ttccatctgt agtcctaacc 420 aggagccccc ccatggaact gcagccccct gtctcccctc agcagtctga gtgcaacccc 480 gttggtgctc tgcaggagct ggtggtgcag aaaggctggc ggttgccgga gtacacagtg 540 acccaggagt ctgggccagc ccaccgcaaa gaattcacca tgacctgtcg agtggagcgt 600 ttcattgaga ttgggagtgg cacttccaaa aaattggcaa agcggaatgc ggcggccaaa 660 atgctgcttc gagtgcacac ggtgcctctg gatgcccggg atggcaatga ggtggagcct 720 gatgatgacc acttctccat tggtgtgggc ttccgcctgg atggtcttcg aaaccggggc 780 ccaggttgca cctgggattc tctacgaaat tcagtaggag agaagatcct gtccctccgc 840 agttgctccc tgggctccct gggtgccctg ggccctgcct gctgccgtgt cctcagtgag 900 ctctctgagg agcaggcctt tcacgtcagc tacctggata ttgaggagct gagcctgagt 960 ggactctgcc agtgcctggt ggaactgtcc acccagccgg ccactgtgtg tcatggctct 1020 gcaaccacca gggaggcagc ccgtggtgag gctgcccgcc gtgccctgca gtacctcaag 1080 atcatggcag gcagcaagtg a 1101 140 219 DNA Human immunodeficiency virus TAT (HIV) U44023 140 atggagccag tagatcctag cctagagccc tggaagcatc caggaagtca gcctaagact 60 gcttgtacca cttgctattg taaagagtgt tgctttcatt gccaagtttg tttcataaca 120 aaaggcttag gcatctccta tggcaggaag aagcggagac agcgacgaag aactcctcaa 180 ggtcatcaga ctaatcaagt ttctctatca aagcagtaa 219 141 22 RNA Synthetic sequence Description of the synthetic sequence: sense strand (Rl A) of a dsRNA that is homologous to an MDR1 sequence 141 ccaucucgaa aagaaguuaa ga 22 142 24 RNA Synthetic sequence Description of the synthetic sequence: antisense strand (RIB) of a dsRNA, that it complementary to an MDR1 sequence 142 ucuuaacuuc uuuucgagau gggu 24 143 22 RNA Synthetic sequence Description of the synthetic sequence: sense strand (R2A) of a dsRNA that is homologous to an MDR1 sequence 143 uauagguucc aggcuugcug ua 22 144 22 RNA Synthetic sequence Description of the synthetic sequence: sense strand (R3A) of a dsRNA that is homologous to an MDR1 sequence 144 ccagagaagg ccgcaccugc au 22 145 24 RNA Synthetic sequence Description of the synthetic sequence: antisense strand (R3B) of a dsRNA, that it complementary to an MDR1 sequence 145 augcaggugc ggccuucucu ggcu 24 146 21 RNA Synthetic sequence Description of the synthetic sequence: sense strand (R4A) of a dsRNA that is homologous to an MDR1 sequence 146 ccaucucgaa aagaaguuaa g 21 147 21 RNA Synthetic sequence Description of the synthetic sequence: antisense strand (R4B) of a dsRNA, that it complementary to an MDR1 sequence 147 uaacuucuuu ucgagauggg u 21 148 22 RNA Synthetic sequence Description of the synthetic sequence: sense strand (S1A) of a dsRNA, that is homologous to the YFP- and GFP sequence, respectively 148 ccacaugaag cagcacgacu uc 22 149 22 RNA Synthetic sequence Description of the synthetic sequence: antisense strand(SlB) of a dsRNA that is complementary to the YFP- and GFP sequence, respectively 149 gaagucgugc ugcuucaugu gg 22 150 21 RNA Synthetic sequence Description of the synthetic sequence: antisense strand(S7A) of a dsRNA that is homologous to the YFP- and GFP sequence, respectively 150 ccacaugaag cagcacgacu u 21 151 21 RNA Synthetic sequence Description of the synthetic sequence: antisense strand(S7B) of a dsRNA, that is complementary to the YFP- and GFP sequence, respectively 151 gucgugcugc uucauguggu c 21 152 24 RNA Synthetic sequence Description of the synthetic sequence: antisense strand(R2B) of a dsRNA that is complementary to the MDR-1 sequence 152 uacagcaagc cuggaaccua uagc 24 153 22 RNA Synthetic sequence Description of the synthetic sequence: sense strand (K1A) of a dsRNA that is homologous to the 5V-UTR of the neomycin sequence 153 acaggaugag gaucguuucg ca 22 154 22 RNA Synthetic sequence Description of the synthetic sequence: antisense strand(KlB) of a dsRNA that is complementary to the 5V-UTR of the neomycin sequence 154 ugcgaaacga uccucauccu gu 22 155 21 RNA Synthetic sequence Description of the synthetic sequence: sense strand (K3A) of a dsRNA that is homologous to the 5-UTR of the neomycin sequence 155 gaugaggauc guuucgcaug a 21 156 21 RNA Synthetic sequence Description of the synthetic sequence: antisense strand(K3B) of a dsRNA that complementary to the 5-UTR of the neomycin sequence 156 augcgaaacg auccucaucc u 21 157 24 RNA Synthetic sequence Description of the synthetic sequence: sense strand (K2A) of a dsRNA that is homologous to the 5^-UTR of the neomycin sequence 157 acaggaugag gaucguuucg caug 24 158 24 RNA Synthetic sequence Description of the synthetic sequence: antisense strand(K2B) of a dsRNA that is complementary to the 5-UTR of the neomycin sequence 158 ugcgaaacga uccucauccu gucu 24 159 24 RNA Synthetic sequence Description of the synthetic sequence: antisense srrand(S4B) of a dsRNA that is complementary to the YFP- and GFP sequence, respectively 159 gaagucgugc ugcuucaugu gguc 24 160 24 RNA Synthetic sequence Description of the synthetic sequence: sense strand (PKC1 A) of a dsRNA that is homologous to the proteinkinase C sequence 160 cuucuccgcc ucacaccgcu gcaa 24 161 22 RNA Synthetic sequence Description of the synthetic sequence: antisense strand(PKC2 B) of a dsRNA that is complementary to the proteinkinase C sequence 161 gcagcggugu gaggcggaga ag 22 162 21 RNA Synthetic sequence Description of the synthetic sequence: antisense strand(S12B) of a dsRNA that is complementary to the YFP- and GFP sequence, respectively 162 aagucgugcu gcuucaugug g 21 163 23 RNA Synthetic sequence Description of the synthetic sequence: antisense strand(S11B) of a dsRNA that is complementary to the YFP- and GFP sequence, respectively 163 aagucgugcu gcuucaugug guc 23 164 20 RNA Synthetic sequence Description of the synthetic sequence: sense strand (S13A) of a dsRNA that is homologous to the YFP- and GFP sequence, respectively 164 ccacaugaag cagcacgacu 20 165 22 RNA Synthetic sequence Description of the synthetic sequence: antisense strand(S13B) of a dsRNA that is complementary to the YFP- and GFP sequence, respectively 165 agucgugcug cuucaugugg uc 22 166 20 RNA Synthetic sequence Description of the synthetic sequence: antisense strand(S14B) of a dsRNA that is complementary to the YFP- and GFP sequence, respectively 166 agucgugcug cuucaugugg 20 167 24 RNA Synthetic sequence Description of the synthetic sequence: sense strand (S4A) of a dsRNA that is homologous to the YFP- and GFP sequence, respectively 167 ccacaugaag cagcacgacu ucuu 24 168 21 RNA Synthetic sequence Description of the synthetic sequence: sense strand (ES-7A) of a dsRNA that is homologous to the human EGFR sequence 168 aacaccgcag caugucaaga u 21 169 21 RNA Synthetic sequence Description of the synthetic sequence: antisense strand(ES-7B) of a dsRNA that is complementary to the human EGFR sequence 169 cuugacaugc ugcgguguuu u 170 22 RNA Synthetic sequence Description of the synthetic sequence: sense strand (ES-8A) of a dsRNA that is homologous to the human EGFR sequence 170 aaguuaaaau ucccgucgcu au 171 22 RNA Synthetic sequence Description of the synthetic sequence: antisense strand(ES-8B) of a dsRNA that is complementary to the human EGFR sequence 171 ugauagcgac gggaauuuua ac 172 22 RNA Synthetic sequence Description of the synthetic sequence: sense strand (ES-2A) of a dsRNA that is homologous to the human EGFR sequence 172 agugugaucc aagcuguccc aa 173 24 RNA Synthetic sequence Description of the synthetic sequence: antisense strand(ES-5B) of a dsRNA that is complementary to the human EGFR sequence 173 uugggacagc uuggaucaca cuuu We Claim: 1. Medicament for inhibiting the expression of a target gene in a cell, containing a double-stranded ribonucleic acid (dsRNA I) in a dosage sufficient to inhibit the expression of the target gene, wherein dsRNA I exhibits a double-stranded structure consisting of a maximum of 49 successive nucleotide pairs, and wherein one strand (asl) or at least one segment of the strand (asl) of the double-stranded structure is complementary to the target gene, and wherein at least one end (El, E2) of the dsRNA I exhibits an overhang consisting of 1 to 4 nucleotides. 2. Medicament as claimed in Claim 1, wherein dsRNA I exhibits the overhang at the 3'-end of one strand (asl) and/or at the 3'-end of the other strand (ssl). 3. Medicament as claimed in Claim 1 or 2, wherein the dsRNA I has a smooth configuration at one end (El, E2). 4. Medicament as claimed in Claim 3, wherein the smooth end (El, E2) contains the 5'-end of the first strand (asl). 5. Medicament as claimed in Claims 1 to 4, wherein the overhang consists of 1 to 4 nucleotides, preferably of 1 or 2 nucleotides. Medicament as claimed in one of the Claims 1 to 5, wherein at least one further double-stranded ribonucleic acid (dsRNA II) having a configuration according to the dsRNA I as defined in Claims 1 to 5, and wherein the one strand (asl) of dsRNA I is complementary to a first region (Bl) of the target gene, and wherein another strand (as2) or at least one segment of the other strand (as2) of dsRNA II is complementary to a second region (B2) of the target gene. Medicament as claimed in one of the Claims 1 to 6, wherein the dsRNA I and/or dsRNA II exhibits a length of fewer than 25, preferably in 19 to 23, successive nucleotide pairs. Medicament as claimed in one of the Claims 1 to 7, wherein the first (Bl) and the second region (B2) overlap segmentally or adjoin each other. Medicament as claimed in one of the Claims 1 to 8, wherein the target gene exhibits one of the sequences SQ001 to SQ140. Medicament as claimed in one of the Claims 1 to 9, wherein the target gene is selected from the following group: oncogene, cytokine gene, Id protein gene, prion gene, genes from angiogenesis-inducing molecules, from adhesion molecules, and from cell-surface receptors; genes from proteins that are involved in metastatic and/or invasive processes; genes from proteinases as well as molecules that regulate apoptosis and the cell cycle. Medicament as claimed in one of the Claims 1 to 10, wherein the target gene is the MRD1 gene. Medicament as claimed in one of the Claims 1 to 11, wherein one of the sequences SQ141-173 or a dsRNA construct being combined of two antisense-(asl/2) and sense sequences (ssl/2) belonging together and belonging to sequences SQ141-173 are used as the dsRNA I/II. Medicament as claimed in one of the Claims 1 to 12, wherein expression is inhibited according to the principle of RNA interference. Medicament as claimed in one of the Claims 1 to 13, wherein the target gene is expressed in pathogenic organisms, most advantageously in plasmodia. 15. Medicament as claimed in one of the Claims 1 to 14, wherein the target gene is a component of a virus or viroid. 16. Medicament as claimed in Claim 15, wherein the virus is a human pathogenic virus or viroid. 17. Medicament as claimed in Claim 15, wherein the virus or viroid is a virus or viroid that is pathogenic in animals or plants. 18. Medicament as claimed in one of the Claims 1 to 17, wherein unpaired nucleotides are substituted with nucleoside thiophosphates. 19. Medicament as claimed in one of the Claims 1 to 18, wherein at least one end (El, E2) of dsRNA I/II is modified in order to counter decomposition in the cell or dissociation in the individual strand. 20. Medicament as claimed in one of the Claims 1 to 19, wherein the cohesion of the double-stranded structure effected by the complementary nucleotide pairs is increased by at least one chemical bond. 21. Medicament as claimed in one of the Claims 1 to 20, wherein the chemical link is achieved either by a covalent or ionic bond, a hydrogen bond, hydrophobic interaction, preferably by means of van der Waals or stacking interactions, or by means of metal-ion coordination. 22. Medicament as claimed in one of the Claims 1 to 21, wherein the chemical link is formed in the vicinity of one end (El, E2). 23. Medicament as claimed in one of the Claims 1 to 22, wherein the chemical link is created by one or several linkage groups, wherein the linkage groups are preferably poly-(oxyphosphinico-oxy-l,3-propandiol) and/or oligoethyleneglycol chains. 24. Medicament as claimed in one of the Claims 1 to 23, wherein the chemical link is formed by using branched nucleotide analogs instead of nucleotides. 25. Medicament as claimed in one of the Claims 1 to 24, wherein the chemical link is formed by purine analogs. 26. Medicament as claimed in one of the Claims 1 to 25, wherein the chemical link is formed by azabenzene units. 27. Medicament as claimed in one of the Claims 1 to 26, wherein at least one of the following groups is used in creating the chemical link: methylene blue; bifunctional groups, preferably bis-(2-chlorethyl)-amine; N-acetyl-N'-(p-glyoxyl-benzoyl)-cystamine; 4-thiouracil; psoralen. 28. Medicament as claimed in one of the Claims 1 to 27, wherein the chemical link is formed by thiophosphoryl groups that are attached in the vicinity of the ends (El, E2) of the double-stranded region. 29. Medicament as claimed in one of the Claims 1 to 28, wherein the chemical link is formed by triple helix bonds that are present in the vicinity of the ends (El, E2). 30. Medicament as claimed in one of the Claims 1 to 29, wherein the dsRNA I/II is enclosed in micellar structures, most advantageously in liposomes. 31. Medicament as claimed in one of the Claims 1 to 30, wherein the dsRNA I/II is bound to, associated with, or enclosed by at least one viral case protein that stems from a virus, is derived from it, or is synthetically produced. Dated this 26th day of May, 2003. HIRAL CHANDRAKANT JOSHI AGENT FOR RIBOPHARMA AG

Documents:

537-mumnp-2003-cancelled page(08-12-2005).pdf

537-mumnp-2003-claim(granted)-(08-12-2005).doc

537-mumnp-2003-claim(granted)-(08-12-2005).pdf

537-mumnp-2003-correspondence(14-12-2005).pdf

537-mumnp-2003-correspondence(ipo)-(04-05-2006).pdf

537-mumnp-2003-form 1(26-05-2003).pdf

537-mumnp-2003-form 19(17-02-2004).pdf

537-mumnp-2003-form 2(granted)-(08-12-2005).doc

537-mumnp-2003-form 2(granted)-(08-12-2005).pdf

537-mumnp-2003-form 3(26-05-2003).pdf

537-mumnp-2003-form 5(26-05-2003).pdf

537-mumnp-2003-pct-ipea-409(26-05-2003).pdf