| Title of Invention | BENZIMIDAZOLE AND PYRIDYLIMIDAZOLE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS |
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| Abstract | TITLE:BENZIMIDAZOLE AND PYRIDYLIMIDAZOLE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS. This invention relates to benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds, all of which may be described by of Formula I. The invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABAA receptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. Novel processes for preparing compounds of Formula I are disclosed. This invention also relates to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of Formula I in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the localization of GABAA receptors in tissue sections. (FIG.NIL) |
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740-kolnp-2003-granted-abstract.pdf
740-kolnp-2003-granted-assignment.pdf
740-kolnp-2003-granted-claims.pdf
740-kolnp-2003-granted-correspondence.pdf
740-kolnp-2003-granted-description (complete).pdf
740-kolnp-2003-granted-examination report.pdf
740-kolnp-2003-granted-form 1.pdf
740-kolnp-2003-granted-form 13.pdf
740-kolnp-2003-granted-form 18.pdf
740-kolnp-2003-granted-form 3.pdf
740-kolnp-2003-granted-form 5.pdf
740-kolnp-2003-granted-gpa.pdf
740-kolnp-2003-granted-letter patent.pdf
740-kolnp-2003-granted-reply to examination report.pdf
740-kolnp-2003-granted-specification.pdf
| Patent Number | 219366 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Indian Patent Application Number | 740/KOLNP/2003 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| PG Journal Number | 18/2008 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Publication Date | 02-May-2008 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Grant Date | 30-Apr-2008 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Date of Filing | 09-Jun-2003 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Name of Patentee | NEUROGEN CORPORATION ; and | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Applicant Address | 35 NORTHEAST INDUSTRIAL ROAD, BRANFORD, CT 06405, UNITED STATES OF AMERICA. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Inventors:
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| PCT International Classification Number | C07D 401/14 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| PCT International Application Number | PCT/US01/50038 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| PCT International Filing date | 2001-12-21 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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