| Title of Invention | " PHARMACEUTICAL COMPOSITION CONTAINING PERMEABILIZING PEPTIDE FOR ENHANCED MUCOSAL DELIVERY OF THERAPEUTIC COMPOUNDS" |
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| Abstract | Compositions and methods are provided that include a biologically active agent and a permeabilizing agent effective to enhance mucosal delivery of the biologically active agent in a mammalian subject. The permeabilizing agent reversibly enhances mucosal epithelial paracellular transport, typically by modulating epithelial junctional structure and/or physiology at a mucosal epithelial surface in the subject. This effect typically involves inhibition by the permeabilizing agent of homotypic or heterotypic binding between epithelial membrane adhesive proteins of neighboring epithelial cells. Target proteins for this blockade of homotypic or heterotypic binding can be selected from various related junctional adhesion molecules (JAMs), occludins, or claudins. The permeabilizing agent is typically a peptide or peptide analog or mimetic, often selected or derived from an extracellular domain of a mammalian JAM, occludin or claudin protein. (FIG. – 1) |
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1852-kolnp-2004-granted-abstract.pdf
1852-kolnp-2004-granted-assignment.pdf
1852-kolnp-2004-granted-claims.pdf
1852-kolnp-2004-granted-correspondence.pdf
1852-kolnp-2004-granted-description (complete).pdf
1852-kolnp-2004-granted-drawings.pdf
1852-kolnp-2004-granted-examination report.pdf
1852-kolnp-2004-granted-form 1.pdf
1852-kolnp-2004-granted-form 18.pdf
1852-kolnp-2004-granted-form 3.pdf
1852-kolnp-2004-granted-form 5.pdf
1852-kolnp-2004-granted-letter patent.pdf
1852-kolnp-2004-granted-pa.pdf
1852-kolnp-2004-granted-priority document.pdf
1852-kolnp-2004-granted-reply to examination report.pdf
1852-kolnp-2004-granted-specification.pdf
1852-kolnp-2004-granted-translated copy of priority document.pdf
| Patent Number | 219511 | ||||||||
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| Indian Patent Application Number | 01951/KOLNP/2004 | ||||||||
| PG Journal Number | 19/2008 | ||||||||
| Publication Date | 09-May-2008 | ||||||||
| Grant Date | 07-May-2008 | ||||||||
| Date of Filing | 17-Dec-2004 | ||||||||
| Name of Patentee | NASTECH PHARMACEUTICAL COMPANY INC. | ||||||||
| Applicant Address | 3450 MONTE VILLA PARKIWAY BOTHELL USA. | ||||||||
Inventors:
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| PCT International Classification Number | A61K38/00 | ||||||||
| PCT International Application Number | PCT/US2003/019994 | ||||||||
| PCT International Filing date | 2003-06-24 | ||||||||
PCT Conventions:
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