Title of Invention	A BLOOD PROCESSING SYSTEM COMMUNICATING WITH A BLOOD SEPARATION DEVICE
Abstract	Blood processing systems (10) and related methods place first (PP1) and second (PP2) fluid actuated pump stations in in-line communication between a source and a destination. The systems and methods apply fluid pressure pump strokes to the first and second pump stations to convey fluid from the source to the destination. The systems and methods switch between a first flow mode and a second flow mode. The first flow draws a fluid volume into the first pump station from the source and expel a fluid volume from the second pump station to the destination. In the second flow mode, the pump strokes draw a fluid volume into the second pump station from the source and expel a fluid volume from the first pump station to the destination. The pump strokes are synchronized so that flow from the source is essentially continuous while fluid flow to the destination is pulsatile.

Title of Invention

A BLOOD PROCESSING SYSTEM COMMUNICATING WITH A BLOOD SEPARATION DEVICE

Abstract

Blood processing systems (10) and related methods place first (PP1) and second (PP2) fluid actuated pump stations in in-line communication between a source and a destination. The systems and methods apply fluid pressure pump strokes to the first and second pump stations to convey fluid from the source to the destination. The systems and methods switch between a first flow mode and a second flow mode. The first flow draws a fluid volume into the first pump station from the source and expel a fluid volume from the second pump station to the destination. In the second flow mode, the pump strokes draw a fluid volume into the second pump station from the source and expel a fluid volume from the first pump station to the destination. The pump strokes are synchronized so that flow from the source is essentially continuous while fluid flow to the destination is pulsatile.

Full Text	FORM 2 THE PATENTS ACT 1970 [39 OF 1970] 8B THE PATENTS RULES, 2003 COMPLETE SPECIFICATION [See Section 10; rule 13] "A BLOOD PROCESSING SYSTEM COMMUNICATING WITH A BLOOD SEPARATION DEVICE" BAXTER INTERNATIONAL INC., a Delaware corporation of One Baxter Parkway, Deerfield, Illinois, 60015, U.S.A. The following specification particularly describes the invention and the manner in which it is to be oerformed: Field of the Invention This invention relates to systems and methods for processing and collecting blood, blood constituents, or other suspensions of cellular material. Background of the Invention Today people routinely separate whole blood, usually by centrifugation, into its various therapeutic components, such as red blood cells, platelets, and plasma. Conventional blood processing methods use durable centrifuge equipment inassociation with single use, sterile processing systems, typically made of plastic. The operator loads the disposable systems' upon the centrifuge before processing and removes them"afterwards., Conventional blood centrifuges are of a size that does not permit easy transport between collection sites. Furthermore, loading and unloading operations can sometimes be time consuming and tedious- In addition, a need exists for further improved systems and methods for collecting blood components in a way that lends itself to use in high volume, on line blood collection environments, where higher yields of critically WE CLAIM; 1. A blood processing system communicating with a blood separation device comprising first and second fluid pressure actuated pump stations, and a fluid pressure actuator operating to selectively apply fluid pressure pump strokes in tandem to the first and second pump stations to convey fluid from a source to a destination, the fluid pressure actuator including a control function to switch between a first flow mode, in which the pump strokes draw a fluid volume into the first pump station from the source and expel a fluid volume from the second pump station to the destination, and a second flow mode, in which the pump strokes draw a fluid volume into the second pump station from the source and expel a fluid volume from the first pump station to the destination, the control function operating to synchronize the pump strokes so that fluid flow from the source is essentially continuous while fluid flow to the destination is pulsatile. 2. A system as claimed in claim 1 wherein the fluid pressure actuator applies positive fluid pressure to expel a volume of fluid from the first and second pump stations. 3. A system as claimed in claim 1 wherein the fluid pressure actuator applies negative fluid pressure to draw a volume of fluid into the first and second pump stations. 4. A system as claimed in claim 1 wherein the fluid pressure actuator applies pneumatic pressure. 5. A system as claimed in claim 1 wherein at least one of the first and second pump stations includes a pump chamber having a stroke volume which is essentially constant. 6. A system as claimed in claim 1 wherein each of the first and second pump stations includes a pump chamber having a stroke volume which is essentially constant. 7. A system as claimed in claim 1 wherein first and second pump stations each includes a pump chamber having a stroke volume which is essentially constant, the stroke volumes of the first and second pump stations being essentially equal. 8. A system as claimed in claim 1 wherein the control function synchronizes the pump strokes so that an expel pump stroke expels a fluid volume from a respective one of the pump stations and a draw pump stroke draws a fluid volume into a respective other one of the pump stations. 9. A system as claimed in claim 8 wherein the draw pump stroke comprises the application of negative fluid pressure. 10. A system as claimed in claim 9 wherein the draw pump stroke comprises the application of negative pneumatic pressure. 11. A system as claimed in claim 8 wherein the expel pump stroke comprises the application of positive fluid pressure. 12 A system as claimed in claim 11 wherein the expel pump stroke comprises the application of positive pneumatic pressure. 13. A system as claimed in claim 8 wherein the draw pump stroke has a duration longer than the expel pump stroke. 14. A system as claimed in claim 13 wherein an expel pump stroke for a respective one of the pump stations occurs at a beginning of a draw pump stroke for a respective other one of the pump stations. 15. A system as claimed in claim 1 wherein the source comprises a venipuncture. 16. A system as claimed in claim 1 wherein the destination communicates with the blood separation device. 17. A system as claimed in claim 1 wherein the destination comprises a reservoir. 18. A system as claimed in claim 1 wherein the source comprises a venipuncture, wherein the destination comprises a reservoir to hold blood drawn from the venipuncture. 19. A system as claimed in claim 18 wherein an inlet flow path coupling the reservoir in communication with a blood separation device, and an inlet pump in the inlet flow path to convey blood from the reservoir to the blood separation device. 20. A system as claimed in claim 19 wherein the inlet pump comprises a third pressure actuated pump station. 21. A system as claimed in claim 20 wherein the fluid pressure actuator operates to selectively apply fluid pressure pump strokes to the third pump station to draw a volume of blood from the reservoir into the third pump station and to expel a volume of blood from the third pump station in a pulsatile flow into the blood separation device. 22. A system as claimed in claim 21 wherein the fluid pressure actuator applies positive fluid pressure to expel a volume of blood from the third pump station. 23. A system as claimed in claim 21 wherein the fluid pressure actuator applies negative fluid pressure to draw a volume of blood into the third pump station. 24. A system as claimed in claim 21 wherein the fluid pressure actuator applies pneumatic pressure. 25. A system as claimed in claim 19 wherein an outlet flow path communication with the blood separation device and an outlet pump in the outlet flow path to convey a separated blood component from the blood separation device. 26. A system as claimed in claim 25 wherein the outlet pump comprises a fourth pressure actuated pump station. 27. A system as claimed in claim 26 wherein the fluid pressure actuator operates to selectively apply fluid pressure pump strokes to the fourth pump station to draw a volume of separated blood from the blood separation device into the fourth pump station and to expel a volume of separated blood from the fourth pump station in a pulsatile flow to a second destination. 28. A system as claimed in claim 27 wherein the fluid pressure actuator applies positive fluid pressure to expel a volume of separated blood from the fourth pump station, 29. A system according to claim 27 wherein the fluid pressure actuator applies negative fluid pressure to draw a volume of separated blood into the fourth pump station. 30. A system as claimed in claim 27 wherein the fluid pressure actuator applies pneumatic pressure. 31. A system as claimed in claim 27 wherein it comprises a flow path coupling the second destination in communication with the first and second pump stations. 32. A system as claimed in claim 31 wherein the fluid pressure actuator also operates to selectively apply fluid pressure pump strokes in tandem to the first and second pump stations to convey the separated blood component from the second destination to the source, the control function operating to switch between a third flow mode, in which the pump strokes draw a separated blood volume into the first pump station from the second destination and expel a separated blood volume from the second pump station to the source, and a fourth flow mode, in which the pump strokes draw a separated blood volume into the second pump station from the second destination and expel a separated blood volume from the first pump station to the source. 33. A system as claimed in claim 32 wherein the control function operates during the third and fourth flow modes to synchronize the pump strokes so that blood flow from the second destination is essentially continuous while blood flow to the source is pulsatile. 34. A system as claimed in claim 1 wherein the source includes a processing fluid container. 35. A system as claimed in claim 1 wherein the source includes a blood collection container. 36. A system as claimed in claim 1 wherein the destination includes a blood collection container. 37. A system as claimed in claim 1 wherein the destination includes an in-line blood filter. 38. A system as claimed in claim 1 wherein the destination includes a venipuncture. 39. A system as claimed in any of the preceding claims, wherein the draw pump stroke has a duration longer than the expel pump stroke, 40. A system as claimed in claim 39, wherein an expel pump stroke for a respective one of the pump stations occurs at a beginning of a draw pump stroke for a respective other one of the pump stations. Dated this 26th day of April, 2001 (RANJNA MEHTA DUTT) OF REMFRY 8B SAGAR ATTORNEY FOR THE APPLICANTS

Full Text

FORM 2
THE PATENTS ACT 1970
[39 OF 1970]
8B
THE PATENTS RULES, 2003
COMPLETE SPECIFICATION
[See Section 10; rule 13]
"A BLOOD PROCESSING SYSTEM COMMUNICATING WITH A BLOOD
SEPARATION DEVICE"
BAXTER INTERNATIONAL INC., a Delaware corporation of One Baxter Parkway, Deerfield, Illinois, 60015, U.S.A.
The following specification particularly describes the invention and the manner in which it is to be oerformed:

Field of the Invention
This invention relates to systems and methods for processing and collecting blood, blood constituents, or other suspensions of cellular material. Background of the Invention
Today people routinely separate whole blood, usually by centrifugation, into its various therapeutic components, such as red blood cells, platelets, and plasma.
Conventional blood processing methods use durable centrifuge equipment inassociation with single use, sterile processing systems, typically made of plastic. The operator loads the disposable systems' upon the centrifuge before processing and removes them"afterwards.,
Conventional blood centrifuges are of a size that does not permit easy transport between collection sites. Furthermore, loading and unloading operations can sometimes be time consuming and tedious- In addition, a need exists for further improved systems and methods for collecting blood components in a way that lends itself to use in high volume, on line blood collection environments, where higher yields of critically

WE CLAIM;
1. A blood processing system communicating with a blood separation device comprising first and second fluid pressure actuated pump stations, and a fluid pressure actuator operating to selectively apply fluid pressure pump strokes in tandem to the first and second pump stations to convey fluid from a source to a destination, the fluid pressure actuator including a control function to switch between a first flow mode, in which the pump strokes draw a fluid volume into the first pump station from the source and expel a fluid volume from the second pump station to the destination, and a second flow mode, in which the pump strokes draw a fluid volume into the second pump station from the source and expel a fluid volume from the first pump station to the destination, the control function operating to synchronize the pump strokes so that fluid flow from the source is essentially continuous while fluid flow to the destination is pulsatile.
2. A system as claimed in claim 1 wherein the fluid pressure actuator applies positive fluid pressure to expel a volume of fluid from the first and second pump stations.
3. A system as claimed in claim 1 wherein the fluid pressure actuator applies negative fluid pressure to draw a volume of fluid into the first and
second pump stations.
4. A system as claimed in claim 1 wherein the fluid pressure actuator applies pneumatic pressure.
5. A system as claimed in claim 1 wherein at least one of the first and second pump stations includes a pump chamber having a stroke volume which is essentially constant.

6. A system as claimed in claim 1 wherein each of the first and second pump stations includes a pump chamber having a stroke volume which is essentially constant.
7. A system as claimed in claim 1 wherein first and second pump stations each includes a pump chamber having a stroke volume which is essentially constant, the stroke volumes of the first and second pump stations being essentially equal.
8. A system as claimed in claim 1 wherein the control function synchronizes the pump strokes so that an expel pump stroke expels a fluid volume from a respective one of the pump stations and a draw pump stroke draws a fluid volume into a respective other one of the pump stations.
9. A system as claimed in claim 8 wherein the draw pump stroke comprises the application of negative fluid pressure.
10. A system as claimed in claim 9 wherein the draw pump stroke comprises the application of negative pneumatic pressure.
11. A system as claimed in claim 8 wherein the expel pump stroke comprises the application of positive fluid pressure.
12 A system as claimed in claim 11 wherein the expel pump stroke comprises the application of positive pneumatic pressure.
13. A system as claimed in claim 8 wherein the draw pump stroke has a duration longer than the expel pump stroke.

14. A system as claimed in claim 13 wherein an expel pump stroke for a respective one of the pump stations occurs at a beginning of a draw pump stroke for a respective other one of the pump stations.
15. A system as claimed in claim 1 wherein the source comprises a venipuncture.
16. A system as claimed in claim 1 wherein the destination communicates with the blood separation device.
17. A system as claimed in claim 1 wherein the destination comprises a reservoir.
18. A system as claimed in claim 1 wherein the source comprises a venipuncture, wherein the destination comprises a reservoir to hold blood drawn from the venipuncture.
19. A system as claimed in claim 18 wherein an inlet flow path coupling the reservoir in communication with a blood separation device, and an inlet pump in the inlet flow path to convey blood from the reservoir to the blood separation device.
20. A system as claimed in claim 19 wherein the inlet pump comprises a third pressure actuated pump station.
21. A system as claimed in claim 20 wherein the fluid pressure actuator operates to selectively apply fluid pressure pump strokes to the third pump station to draw a volume of blood from the reservoir into the third pump station and to expel a volume of blood from the third pump station in a pulsatile flow into the blood separation device.

22. A system as claimed in claim 21 wherein the fluid pressure actuator applies positive fluid pressure to expel a volume of blood from the third pump station.
23. A system as claimed in claim 21 wherein the fluid pressure actuator applies negative fluid pressure to draw a volume of blood into the third pump station.
24. A system as claimed in claim 21 wherein the fluid pressure actuator applies pneumatic pressure.
25. A system as claimed in claim 19 wherein an outlet flow path communication with the blood separation device and an outlet pump in the outlet flow path to convey a separated blood component from the blood separation device.
26. A system as claimed in claim 25 wherein the outlet pump comprises a fourth pressure actuated pump station.
27. A system as claimed in claim 26 wherein the fluid pressure actuator operates to selectively apply fluid pressure pump strokes to the fourth pump station to draw a volume of separated blood from the blood separation device into the fourth pump station and to expel a volume of separated blood from the fourth pump station in a pulsatile flow to a second destination.
28. A system as claimed in claim 27 wherein the fluid pressure actuator applies positive fluid pressure to expel a volume of separated blood from the fourth pump station,
29. A system according to claim 27 wherein the fluid pressure actuator

applies negative fluid pressure to draw a volume of separated blood into the fourth pump station.
30. A system as claimed in claim 27 wherein the fluid pressure actuator applies pneumatic pressure.
31. A system as claimed in claim 27 wherein it comprises a flow path coupling the second destination in communication with the first and second pump stations.
32. A system as claimed in claim 31 wherein the fluid pressure actuator also operates to selectively apply fluid pressure pump strokes in tandem to the first and second pump stations to convey the separated blood component from the second destination to the source, the control function operating to switch between a third flow mode, in which the pump strokes draw a separated blood volume into the first pump station from the second destination and expel a separated blood volume from the second pump station to the source, and a fourth flow mode, in which the pump strokes draw a separated blood volume into the second pump station from the second destination and expel a separated blood volume from the first pump station to the source.
33. A system as claimed in claim 32 wherein the control function operates during the third and fourth flow modes to synchronize the pump strokes so that blood flow from the second destination is essentially continuous while blood flow to the source is pulsatile.
34. A system as claimed in claim 1 wherein the source includes a processing fluid container.

35. A system as claimed in claim 1 wherein the source includes a blood collection container.
36. A system as claimed in claim 1 wherein the destination includes a blood collection container.
37. A system as claimed in claim 1 wherein the destination includes an in-line blood filter.
38. A system as claimed in claim 1 wherein the destination includes a venipuncture.
39. A system as claimed in any of the preceding claims, wherein the draw pump stroke has a duration longer than the expel pump stroke,
40. A system as claimed in claim 39, wherein an expel pump stroke for a respective one of the pump stations occurs at a beginning of a draw pump stroke for a respective other one of the pump stations.
Dated this 26th day of April, 2001
(RANJNA MEHTA DUTT) OF REMFRY 8B SAGAR ATTORNEY FOR THE APPLICANTS

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Patent Number

219972

Indian Patent Application Number

IN/PCT/2001/00462/MUM

PG Journal Number

33/2008

Publication Date

15-Aug-2008

Grant Date

15-May-2008

Date of Filing

26-Apr-2001

Name of Patentee

BAXTER INTERNATIONAL INC

Applicant Address

ONE BAXTER PARKWAY, DEERFIELD, ILLINOIS, 60015, USA

Inventors:

#	Inventor's Name	Inventor's Address
1	ROHIT VISHNOI
2	MARK R. VANDLIK
3	TOM WESTBERG

PCT International Classification Number

A61M37/00 C02F1/00

PCT International Application Number

PCT/US00/23675

PCT International Filing date

2000-08-29

PCT Conventions:

#	PCT Application Number	Date of Convention	Priority Country
1	09/390,265	1999-09-03	U.S.A.