| Title of Invention | METHOD FOR PREPARATION OF Z-ISOMER OF 4-CHLORO-1, 2-DIPHENYL-1- [4-[2-(N,N-DIMETHYLAMINO) ETHOXY] PHENYL]-1-BUTENE |
|---|---|
| Abstract | The invention relates to a method for isolating toremifene from a mixture of toremifene and its corresponding E isomer. The method comprises contacting the isomer mixture with a first solvent comprising methanol, allowing toremifene to crystallize in said first solvent, allowing the crystallized product of the previous step to crystallize from a second solvent comprising acetone, methyl ethyl ketone or ethyl acetate, and optionally converting toremifene crystallized from the previous step to a pharmaceutically acceptable salt thereof. |
| Full Text |
|---|
02113-kolnp-2005-description complete.pdf
02113-kolnp-2005-international publication.pdf
2113-kolnp-2005-granted-abstract.pdf
2113-kolnp-2005-granted-assignment.pdf
2113-kolnp-2005-granted-claims.pdf
2113-kolnp-2005-granted-correspondence.pdf
2113-kolnp-2005-granted-description (complete).pdf
2113-kolnp-2005-granted-examination report.pdf
2113-kolnp-2005-granted-form 1.pdf
2113-kolnp-2005-granted-form 18.pdf
2113-kolnp-2005-granted-form 3.pdf
2113-kolnp-2005-granted-form 5.pdf
2113-kolnp-2005-granted-gpa.pdf
2113-kolnp-2005-granted-letter patent.pdf
2113-kolnp-2005-granted-reply to examination report.pdf
2113-kolnp-2005-granted-specification.pdf
| Patent Number | 221143 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Indian Patent Application Number | 02113/KOLNP/2005 | |||||||||
| PG Journal Number | 25/2008 | |||||||||
| Publication Date | 20-Jun-2008 | |||||||||
| Grant Date | 18-Jun-2008 | |||||||||
| Date of Filing | 25-Oct-2005 | |||||||||
| Name of Patentee | ORION CORPORATIOIN | |||||||||
| Applicant Address | ORIONINTIE 1, FI-02200 ESPOO | |||||||||
Inventors:
|
||||||||||
| PCT International Classification Number | C07C 213/10 | |||||||||
| PCT International Application Number | PCT/FI2004/000304 | |||||||||
| PCT International Filing date | 2004-05-19 | |||||||||
PCT Conventions:
|
||||||||||