| Title of Invention | SUSTAINED RELEASE OF GUAIFENESIN COMBINATION DRUGS |
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| Abstract | The invention relates to a novel pharmaceutical modified release formulation of guaifenesin and optionally a second drug which is preferably selected from dextromethorphan and pseudoephedrine. The formulation may comprise a hydrophilic polymer, preferably a hydroxypropyl methylcellulose, and a waterinsoluble polymer, preferably an acrylic resin, in a ratio range of about one-to-one (1:1) to about nine-to-one (9:1), more preferably a range of about three-to-two (3:2) to about six-to-one (6:1), and most preferably in a range of about two-to-one (2:1) to about four-to-one (4:1) by weight. This formulation capable of providing therapeutically effective bioavailability of guaifenesin for at least twelve hours after dosing in a human subject. The invention also relates to a modified release product which has two portions: a first portion having an immediate release formulation of guaifenesin and a second portion having a sustained release formulation of guaifenesin, wherein one or both portions further comprises dextromethorphan. The modified release product has a maximum guaifenesin serum concentration equivalent to that of an immediate release guaifenesin tablet, and is capable of providing therapeutically effective bioavailability of guaifenesin for at least twelve hours after dosing in a human subject. |
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1599-KOLNP-2004-(13-10-2011)-ASSIGNMENT.pdf
1599-KOLNP-2004-(13-10-2011)-CERTIFIED COPIES(OTHER COUNTRIES).pdf
1599-KOLNP-2004-(13-10-2011)-CORRESPONDENCE.pdf
1599-KOLNP-2004-(13-10-2011)-FORM 13-1.1.pdf
1599-KOLNP-2004-(13-10-2011)-FORM 13.pdf
1599-KOLNP-2004-(13-10-2011)-FORM 16-1.1.pdf
1599-KOLNP-2004-(13-10-2011)-FORM 16-1.2.pdf
1599-KOLNP-2004-(13-10-2011)-FORM 16.pdf
1599-KOLNP-2004-(13-10-2011)-OTHERS.pdf
1599-KOLNP-2004-(13-10-2011)-PA.pdf
1599-KOLNP-2004-(13-10-2011)-PETION UNDER RULE 137-1.1.pdf
1599-KOLNP-2004-(13-10-2011)-PETION UNDER RULE 137.pdf
1599-KOLNP-2004-CORRESPONDENCE-1.1.pdf
1599-KOLNP-2004-CORRESPONDENCE.pdf
1599-kolnp-2004-granted-abstract.pdf
1599-kolnp-2004-granted-assignment.pdf
1599-kolnp-2004-granted-claims.pdf
1599-kolnp-2004-granted-correspondence.pdf
1599-kolnp-2004-granted-description (complete).pdf
1599-kolnp-2004-granted-drawings.pdf
1599-kolnp-2004-granted-examination report.pdf
1599-kolnp-2004-granted-form 1.pdf
1599-kolnp-2004-granted-form 18.pdf
1599-kolnp-2004-granted-form 3.pdf
1599-kolnp-2004-granted-form 5.pdf
1599-kolnp-2004-granted-gpa.pdf
1599-kolnp-2004-granted-letter patent.pdf
1599-kolnp-2004-granted-reply to examination report.pdf
1599-kolnp-2004-granted-specification.pdf
| Patent Number | 221152 | ||||||||||||||||
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| Indian Patent Application Number | 1599/KOLNP/2004 | ||||||||||||||||
| PG Journal Number | 23/2008 | ||||||||||||||||
| Publication Date | 20-Jun-2008 | ||||||||||||||||
| Grant Date | 18-Jun-2008 | ||||||||||||||||
| Date of Filing | 25-Oct-2004 | ||||||||||||||||
| Name of Patentee | ADAMS LABORATORIES, INC. | ||||||||||||||||
| Applicant Address | 14801 SOVEREIGN ROAD, FORT WORTH, TX 76155-2645 | ||||||||||||||||
Inventors:
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| PCT International Classification Number | A61K 9/20 | ||||||||||||||||
| PCT International Application Number | PCT/US03/11500 | ||||||||||||||||
| PCT International Filing date | 2003-04-15 | ||||||||||||||||
PCT Conventions:
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