Title of Invention

5-PHENYL-PYRIMIDINE DERIVATIVES

Abstract

ABSTRACT IN/PCT/2001/1649/CHE "5-Phenyl-pyrimidine Derivatives" The present invention relates to compounds of general formula (I) wherein R] is hydrogen or halogen; R2 is hydrogen, halogen, lower alkyl or lower alkoxy; R3 is halogen, trifluoromethyl, lower alkoxy or lower alkyl; R4/R4" are independently from ech other hydrogen or lower alkyl; R5 is lower alkyl, lower alkoxy, amino, hydroxy, hydroxy-lower alkyl, -(CH2)n-piperazinyl, optionally substituted by lower alkyl,-(CH2)n-morpholinyl, -(CH2)n+i - imidazolyl, -0-(CH2)n+i-morpholinyl, -0-(CH2)n+i-piperidinyl, lower alkyl-sulfanyl, lower alkyl-sulfonyl, benzylamino, -NH-(CH2)n+i N(R4)2, -(CH2)n. NH-(CH2)n.1N(R4-)2,-(CH2)n+1N(R4-)2, or-0-(CH2)n+1N(R4)2, wherein R4" is hydrogen or lower alkyl; R6 is hydrogen; R2 and R6 or R1 and R6 may be together with the two carbon ring atoms -CH=CH-CH-CH=CH, with the proviso that n for R1 is 1; n is independently 0-2; and X is -C(0)N(R4> or-N(R4")C(0)-; and pharmaceutical^ acceptable acid addition salts thereof. Compounds of formula (I) have a high affinity to the NK-1 receptor. They are therefore useful for the treatment or diseases which relate to this receptor.

Full Text

5-Phenyl-pyrimidine derivatives The present invention relates to compounds of the general formula wherein R is hydrogen or halogen; 5 R" is hydrogen, halogen, lower alkyl or lower alkoxy; R" is halogen, trifluoromethyl, lower alkoxy or lower alkyl; are independently from each other hydrogen or lower alkyl; R? is lower alkyl, lower alkoxy, amino, hydroxy, hydroxy-lower alkyl, -(CH:)n-piperazinyl, optionally substituted by lower alkyl, 10 -(CH2)n-morpholinyl, -(CH;)„n-imidazolyl, -0-(CH2)n+i-niorpholinyl, -0-(CH2)nti-piperidinyl, lower alkyl-sulfanyl, lower alkyl-sulfonyl, benzylamino, -NH-(CH2)n+1N(R4")2) -(CH2)n-NH-(CH:)n+1N(Rr'):, -(CH2)n+1N(R4'")2, or -0-(CH2)n+tN(R4 )2, wherein R4 is hydrogen or lower alkyl; R6 is hydrogen; 15 R: and R6 or R1 and R6 may be together with the two carbon ring atoms -CH=CH-CH=CH-, with the proviso that n for Rl is 1; n is independently 0-2; and X is -C(0)N(R4")- or -N(R4")C(0)-; and to pharmaceutically acceptable acid addition salts thereof. Pop/07.03.2000 The compounds of formula I and their salts are characterized by valuable therapeutic properties. It has been surprisingly found that the compounds of the present invention are antagonists of the Neurokinin 1 (NK-1, substance P) receptor. Substance P is a naturally occurring undecapeptide belonging to the tachykinin family of peptides, the latter being 5 so-named because of their prompt contractile action on extravascular smooth muscle tissue. The receptor for substance P is a member of the superfamily of G protein-coupled receptors. The neuropeptide receptors for substance P (NK-1) are widely distributed 10 throughout the mammalian nervous system (especially brain and spinal ganglia), the circulatory system and peripheral tissues (especially the duodenum and jejunum) and are involved in regulating a number of diverse biological processes. The central and peripheral actions of the mammalian tachykinin substance P have been associated with numerous inflammatory conditions including migraine, rheumatoid 15 arthritis, asthma, and inflammatory bowel disease as well as mediation of the emetic reflex and the modulation of central nervous system (CNS) disorders such as Parkinson's disease (Neurosci. Res., 1996, 7,187-214), anxiety (Can. J. Phys., 1997, 75, 612-621) and depression (Science, 1998,281,1640-1645). Evidence for the usefulness of tachykinin receptor antagonists in pain, headache, especially 20 migraine, Alzheimer's disease, multiple sclerosis, attenuation of morphine withdrawal, cardiovascular changes, oedema, such as oedema caused by thermal injury, chronic inflammatory diseases such as rheumatoid arthritis, asthma/bronchial hyperreactivity and other respiratory diseases including allergic rhinitis, inflammatory diseases of the gut including ulcerative colitis and Crohn's disease, ocular injury and ocular inflammatory 25 diseases reviewed in "Tachykinin Receptor and Tachykinin Receptor Antagonists", J. Auton. Pharmacol., 13, 23-93,1993. Furthermore, Neurokinin 1 receptor antagonists are being developed for the treatment of a number of physiological disorders associated with an excess or imbalance of tachykinin, in particular substance P. Examples of conditions in which substance P has 30 been implicated include disorders of the central nervous system such as anxiety, depression and psychosis (WO 95/16679, WO 95/18124 and WO 95/23798). The neurokinin-1 receptor antagonists are further useful for the treatment of motion sickness and for treatment induced vomiting. In addition, in The New England Journal of Medicine, Vol. 340, No. 3 190-195,1999 has 35 been described the reduction of cisplatin-induced emesis by a selective neurokinin-1-receptor antagonist. Objects of the present invention are the compounds of formula I and pharma¬ceutical^ acceptable salts thereof, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture as well as the use of the above-mentioned compounds in the control or prevention of illnesses, especially of illnesses and disorders of the kind referred to earlier or in the manufacture of corresponding medicaments. The most preferred indications in accordance with the present invention are those, which include disorders of the central nervous system, for example the treatment or prevention of certain depressive disorders or emesis by the administration of NK-1 receptor antagonists. A major depressive episode has been defined as being a period of at least two weeks during which, for most of the day and nearly every day, there is either depressed mood or the loss of interest or pleasure in all, or nearly all activities. The following definitions of the general terms used in the present description apply irrespective of whether the terms in question appear alone or in combination. As used herein, the term "lower alkyl" denotes a straight- or branched-chain alkyl group containing from 1-7 carbon atoms, for example, methyl, ethyl, propyl, isopropyl, n-butyl, i-butyl, t-butyl and the like. Preferred lower alkyl groups are groups with 1-4 carbon atoms. The term "lower alkoxy" denotes a group wherein the alkyl residues are as defined above, and which is attached via an oxygen atom. The term "halogen" denotes chlorine, iodine, fluorine and bromine. The term "pharmaceutically acceptable acid addition salts" embraces salts with inorganic and organic acids, such as hydrochloric acid, nitric acid, sulfuric acid, phosphoric acid, citric acid, formic acid, fumaric acid, maleic acid, acetic acid, succinic acid, tartaric acid, methane-sulfonic acid, p-toluenesulfonic acid and the like. Exemplary preferred are compounds, in which X is -C(0)N(R4 )-, wherein R is methyl and R? is -(CH2)n-piperazinyl, optionally substituted by methyl, and n is 0 or 1, for example the following compounds: 5-(2-chloro-phenyl)-2-(4-methyl-piperazin-l-yl)-pyrimidine-4-carboxylicacid(3,5-bis- trifluoromethyl-benzyl)-methyl-amide, 5-(4-fluoro-2-methyl-phenyl)-2-(4-methyl-piperazin-l-yl)-pyrimidine-4-carboxylicacid (3,5-bis-trifluoromethyl-benzyl)-methyl-amideor 5-(2-chloro-phenyl)-2-(4-methyl-piperazin-l-ylmethyl)-pyrimidine-4-carboxylicacid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide. Further preferred are compounds, in which X is -C(0)N(R4")-, wherein R4" is methyl and R"1 is -0(CH2)2-morpholinyl. An examples of such a compound is 5-(2-chloro-phenyl)-2-(2-morpholin-4-yl-ethoxy)-pyrimidine-4-carboxylicacid(3,5-bis-trifluoromethyl-benzyl)-methyl-amid. Preferred are further compounds, in which X is -C(0)N(R4")-> R4" is methyl and R5 is-NH(CH2)ntiN(CH,)2, -(CH2)n-NH(CH2)n+1N(CH3)2 or -0(CH2)n+1N(CH3)2, wherein n is 1 or 2, for example the following compounds: 5-(2-chloro-phenyl)-2-(2-dimethylamino-ethylamino)-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide, 2-(2-dimethyIamino-ethylamino)-5-o-tolyl-pyrimidine-4-carboxylicacid (3,5-bis- trifluoromethyl-benzyl)-methyl-amide, 2-(2-dimethylamino-ethylamino)-5-(2-methoxy-phenyl)-pyrimidine-4-carboxylicacid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide, 2-(2-dimethylamino-ethylamino)-5-(4-fluoro-phenyl)-pyrimidine-4-carboxylicacid (3,5- bis-trifluoromethyl-benzyl)-methyl-amide, 2-(2-dimethylamino-ethylamino)-5-(4-fluoro-2-methyl-phenyl)-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-ben2yl)-methyl-amide, 5-(2-chloro-phenyl)-2-(3-dimethylamino-propoxy)-pyrimidine-4-carboxylicacid (3,5-bis- trifluoromethyl-benzyl)-methyl-amide, 5-(2-chloro-phenyl)-2-(2-dimethylamino-ethoxy)-pyrimidine-4-carboxylicacid (3,5-bis- trifluoromethyl-benzyl)-methyl-amide, 2-(2-dimethylamino-ethoxy)-5-o-tolyl-pyrimidine-4-carboxylicacid (3,5-bis- trifluoromethyl-benzyl)-methyl-amide, 2-(3-dimethylamino-propoxy)-5-o-tolyl-pyrimidine-4-carboxylic acid (3,5-bis- trifluoromethyl-benzyl)-methyl-amide, 2-(2-dimethylamino-propoxy)-5-(2-methoxy-phenyl)-pyrimidine-4-carboxylicacid (3,5- bis-trifluoromethyl-benzyl)-methyl-amide, 2-(3-dimethylamino-propoxy)-5-(4-fluoro-2-methyl-phenyl)-pyrimidine-4-carboxylic acid(3,5-bis-trifluoromethyl-benzyl)-methyl-amide, 2-(2-dimethylamino-ethoxy)-5-(4-fluoro-2-methyl-phenyl)-pyrimidine-4-carboxylicacid (3,5-bis-trifluoromethyl-benzyl)-methyl-amideor 5-(2-chloro-phenyl)-2-[(2-dimethylamino-ethylamino)-methyl]-pyrimidine-4-carboxylic acid(3,5-bis-trifluoromethyl-benzyl)-methyl-amide. Further preferred are compounds, wherein X is -CON(R4")2 and R4" is methyl and R5 is SCH3, for example the following compounds: 2-methylsulfanyl-5-o-tolyl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide or 5-(4-fluoro-2-methyl-phenyl)-2-methylsulfanyl-pyrimidine-4-carboxylicacid(3,5-bis-trifluoromethyl-benzyl)-methyl-amide. Other preferred compounds are those, in which X is -CON(R4' )2 and R4" is methyl and R2 and R6or R1 and R6 are together with the two carbon ring atoms -CH=CH-CH=CH-, for example the following compounds: 2-(4-methyl-piperazin-l-yl)-5-naphthalen-l-yl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide, 2-(2-dimethylamino-ethylamino)-5-naphthalen-l-yl-pyrimidine-4-carboxylicacid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide, 2-(2-dimethylamino-ethoxy)-5-naphthalen-l-yl-pyrimidine-4-carboxylicacid(3,5-bis- trifluoromethyl-benzyl)-methyl-amide, 2-(2-morpholin-4-yl-ethoxy)-5-naphthalen-l-yl-pyrimidine-4-carboxylicacid (3,5-bis- trifluoromethyl-benzyl)-methyl-amideor 2-(3-dimethylamino-propoxy)-5-naphthalen-l-yl-pyrimidine-4-carboxylicacid(3,5-bis- trifluoromethyl-benzyl)-methyl-amide. Further preferred are compounds, wherein X is -N(R4 )C(0)-, R4 is lower alkyl and R? is -(CH2)n-piperazinyl, optionally substituted by lower alkyl, -(CH2)n-morpholinyl, -NH-(CH2)n+1N(CH3)2or -0-(CH2)n+iN(CH3)2, for example the following compounds: 2-(3,5-bis-trifluoromethyl-phenyl)-N-methyl-N-[2-(4-methyl-piperazin-l-yl)-5-o-tolyl-pyrimidin-4-yl]-isobutyramide, 2-(3,5-bis-trifluoromethyl-phenyl)-N-methyl-N-(2-piperazin-l-yl-5-o-tolyl-pyrimidin-4-yl) -isobutyramide, 2-(3,5-bis-trifluoromethyl-phenyl)-N-methyl-N-(2-morpholin-4-yl-5-o-tolyl-pyrimidin-4-yl)-isobutyramide, 2-(3,5-bis-trifluoromethyl-phenyl)-N-[2-(2-dimethylamino-ethylamino)-5-o-tolyl-pyrimidin-4-yl]-N-methyl-isobutyramide, 2-(3,5-bis-trifluoromethyl-phenyl)-N-[2-(2-dimethylamino-ethoxy)-5-o-tolyl-pyrimidin-4-yI] -N-methyl-isobutyramide, 2-(3,5-bis-trifluoromethyl-phenyl)-N-[5-(2-chloro-phenyl)-2-(4-methyl-piperazin-l-yl)-pyrimidin-4-yl]-N-methyl-isobutyramide or 2-(3,5-bis-trifluoromethyl-phenyl)-N-[5-(2-chloro-phenyl)-2-(2-dimethylamino-ethylamino)-pyrimidin-4-yl]-N-methyl-isobutyramide. The present compounds of formula I and their pharmaceutical^ acceptable salts can be prepared by methods known in the art, for example, by processes described below, 5 which process comprises wherein R -R" and n have the significances given above, or c) modifying one or more substituents R'-R5 within the definitions given above, and if desired, converting the compound obtained into a pharmaceutically acceptable acid addition salt. In accordance with process variant a) a compound of formula II, for example [5-(2-chloro-phenyl)-2-methylsulfonyl-pyrimidin-4-yl]-methyl-amine is deprotected with KHMDS (potassium hexamethyldisilazide) in THF at 0° for 1 h and a compound of formula III, for example 2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride is added and the mixture is stirred at room temperature. A typical solvent is N,N-dimethylformamide. The desired compound of formula 1-1 is obtained in good yields. Process variant b) describes the reaction of a compound of formula IV with a compound of formula V to a compound of formula 1-2. The reaction is carried out in conventional manner, for example in a solvent, such as dichloromethane in presence of NEt3, EDCI (N-(3-dimethylaminopropyl)-N'-ethyl-carbodiimide hydrochloride) and HOBT (1-hydroxy-benzotriazole). The mixture is stirred for about 12 hs at room temperature. The desired product is obtained after purification in good yields. The salt formation is effected at room temperature in accordance with methods which are known per se and which are familiar to any person skilled in the art. Not only salts with inorganic acids, but also salts with organic acids came into consideration. Hydrochlorides, hydrobromides, sulphates, nitrates, citrates, acetates, maleates, succinates, methan-sulphonates, p-toluenesulphonates and the like are examples of such salts. The following schemes 1-6 describe the processes for preparation of compounds of formula I in more detail. The starting materials of formulae III, VIII, IX, XII, XIII, XVI, XVII and XII are known compounds and may be prepared according to methods known in the art. In the schemes the following abbreviations have been used: THF tetrahydrofuran DIPEA N-ethyldiisopropyl-amine HOBT 1-hydroxy-benzotriazole EDCI N-(3-dimethylaminopropyl)-N'-ethyl-carbodiimide hydrochloride m-CPBA m-chloroperbenzoic acid DPPA diphenylphosphorylazide DMF dimethylformamide NEt3 triethylamine KHMDS potassium hexamethyldisilazide The substituents R1 - R6 are given above. A is an amine group, such as amino, piperazinyl, optionally substituted by lower alkyl, morpholinyl, imidazolyl, piperidinyl.benzylamino or -NH-(CH2)n+iN(R4 )2, and B is lower alkoxy, -0-(CH2)n+i-morpholinyl, -0-(CH2)n+i-piperidinylor -0-(CH2)n+iN(R4 )2; The substituents R1 - R6 are given above. A is an amine group, such as amino, piperazinyl, optionally substituted by lower alkyl, morpholinyl, imidazolyl, piperidinyl,benzylamino or -NH-(CH2)n+iN(R4 )2. The substituents R1 - R6 are given above. A is an amine group, such as amino, piperazinyl, optionally substituted by lower alkyl, morpholinyl, imidazolyl, piperidinyl,benzylamino or -NH-(CH:)nl-iN(R ):, and B is 5 lower alkoxy, -0-(CH2)n+i-morpholinyl, -0-(CH2)n+i-piperidinyl or -0-(CH2)n+iN(R4 )2; As mentioned earlier, the compounds of formula I and their pharmaceutical^ usable addition salts possess valuable pharmacological properties. It has been found that the compounds of the present invention are antagonists of the Neurokinin 1 (NK-1, substance P) receptor. The compounds were investigated in accordance with the tests given hereinafter. The affinity of test compounds for the NKi receptor was evaluated at human NKj receptors in CHO cells infected with the human NKi receptor (using the Semliki virus expression system) and radiolabeled with ['Hjsubstance P (final concentration 0.6 nM). Binding assays were performed in HEPES buffer (50 mM, pH 7.4) containing BSA (0.04 %) leupeptin (8 ug / ml), MnCb (3mM) and phosphoramidon (2 uM). Binding assays consisted of 250 ul of membrane suspension (1.25xl05 cells / assay tube), 0.125 ul of buffer of displacing agent and 125 ul of [* Hjsubstance P. Displacement curves were determined with at least seven concentrations of the compound. The assay tubes were incubated for 60 min at room temperature after which time the tube contents were rapidly filtered under vacuum through GF/C filters presoaked for 60 min with PEI (0.3%) with 2 x 2 ml washed of HEPES buffer (50 mM, pH 7.4). The radioactivity retained on the filters was measured by scintillation counting. All assays were performed in triplicate in at least 2 separate experiments. The affinity to the NK-1 receptor, given as pKi, is in the scope of 8.00-9.30 for the preferred compounds. Examples of such compounds are The compounds of formula I as well as their pharmaceutically usable acid addition salts can be used as medicaments, e.g. in the form of pharmaceutical preparations. The pharmaceutical preparations can be administered orally, e.g. in the form of tablets, coated tablets, dragees, hard and soft gelatine capsules, solutions, emulsions or suspensions. The administration can, however, also be effected rectally, e.g. in the form of suppositories, or parenterally, e.g. in the form of injection solutions. The compounds of formula I and their pharmaceutically usable acid addition salts can be processed with pharmaceutically inert, inorganic or organic excipients for the production of tablets, coated tablets, dragees and hard gelatine capsules. Lactose, corn starch or derivatives thereof, talc, stearic acid or its salts etc can be used as such excipients e.g. for tablets, dragees and hard gelatine capsules. Suitable excipients for soft gelatine capsules are e.g. vegetable oils, waxes, fats, semi¬solid and liquid polyols etc. Suitable excipients for the manufacture of solutions and syrups are e.g. water, polyols, saccharose, invert sugar, glucose etc. Suitable excipients for injection solutions are e.g. water, alcohols, polyols, glycerol, vegetable oils etc. Suitable excipients for suppositories are e.g. natural or hardened oils, waxes, fats, semi-liquid or liquid polyols etc. Moreover, the pharmaceutical preparations can contain preservatives, solubilizers, stabilizers, wetting agents, emulsifiers, sweeteners, colorants, flavorants, salts for varying the osmotic pressure, buffers, masking agents or antioxidants. They can also contain still other therapeutically valuable substances. The dosage can vary within wide limits and will, of course, be fitted to the individual i requirements in each particular case. In general, in the case of oral administration a daily dosage of about 10 to 1000 mg per person of a compound of general formula I should be appropriate, although the above upper limit can also be exceeded when necessary. The following Examples illustrate the present invention without limiting it. All temperatures are given in degrees Celsius. Example 1 2-Methylsulfanyl-5-phenyI-pyrimidine-4-carboxylicacid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide a) 5-Bromo-2-methvlsuIfanvl-pvrimidine-4-carboxvlic acid 3.5-bis-trifluoromethvl- benzylamide To a solution of 3.54 g (14.21 mmol) 5-bromo-2-methylsulfanyl-pyrimidine-4-carboxylic 3.92 ml (28.24 mmol) triethylamin, 2.17 g (14.21 mmol) 1 -hydroxy-benzotriazol and 2.72 g (14.21 mmol) N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride acid in 200 ml CH2CI2 3.80 g (15.63 mmol) 3,5-bis-trifiuormethyl-benzylamin were added. The reaction mixture was stirred for 16 hrs. The reaction mixture was washed with 100 ml 0.5N HC1 and 100 ml H20. The aqueous layers were backextracted with 100 ml CH2Ck The combined organic layers were dried (MgS04), filtered and evaporated. The residue was purified by chromatography (SiOi, CH2G2) to give 4.70 g (69%) 5-bromo-2-methylsulfanyl-pyrimidine-4-carboxylic acid 3,5-bis-trifluoromethyl-benzylamide as a colorless solid. b) 5-Bromo-2-methvlsulfanv]-pvTimidine-4-carboxvlic acid (3,5-bis-trifiuoromethyI- benzvD-methvl-amide To a solution of 4.40 g (9.28 mmol) 5-bromo-2-methylsulfanyl-pyrimidine-4-carboxylic acid 3,5-bis-trifluoromethyl-benzylamide in 50 ml N,N-dimethylformamide 0.48 g (12.06 mmol) sodiumhydride (60% dispersion in mineral oil) was added and the reaction mixture stirred for 1 hr. After the addition of 0.92 ml (14.85 mmol) methyl iodide at 0°, the reaction mixture was stirred for 3 hrs. at RT. The reaction mixture was distributed between 100 ml H20,100 ml brine and 100 ml CH2CI2. The phases were separated, the aqueous layer washed twice with 100 ml CH2CI2. The combined organic layers were dried (MgS04)> filtered and evaporated. The residue was purified by chromatography (SiCb, CH^C^/ethyl acetate 40:1) to give 3.50 g (77 %) 5-bromo-2-methylsulfanyl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide as a colorless oil. c) 2-Methylsulfanvl-5-phenvl-pvrimidine-4-carboxvlic acid (3,5-bis-trifluoromethyl- benzvP-methvl-amide To a suspension of 3.50 g (7.17 mmol) 5-bromo-2-methylsulfanyl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyI-amide, 0.213 g (0.2 mmol) tetrakis-(triphenylphosphin)palladium and 0.96 g (7.89 mmol) phenylboronic acid in 40 ml 1,2-dimethoxyethane a solution of 0.83 g (7.89 mmol) NaiCO.i in 15 ml H2O was added. The resulting reaction mixture was heated at reflux for 16 hrs. After evaporation of the 1,2-dimethoxyethan, the aqueous phase was extracted twice with 50 ml CH2CI2. The combined organic layers were dried (MgSC^), filtered and evaporated. The residue was purified by chromatography (Si02, CH2Cl2/ethyl acetate 40:1) and crystallised to give 2.4 g (69 %) 2-methylsulfanyl-5-phenyl-pyrimidine-4-carboxylicacid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide as off-white crystalls, m.p 109.7-110.7°. Example 2 2-Methanesulfonyl-5-phenyl-pyrimidine-4-carboxylicacid(3>5-bis-trifluoromethyl-benryl)-methyl-amide To a solution of 2.30 g (4.74 mmol) 2-methylsulfanyl-5-phenyl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide in 90 ml CH2CI2 2.92 g (11.4 mmol) 3-chloroperbenzoic acid (70%) was added at 5° and the reaction mixture stirred for 3 hrs. at RT. After addition of 100 ml sat. NaHCO?-solution, the layers were separated, the organic phase washed with sat. NaHCO?-solution, dried (NaiSO.}), filtered and evaporated. The residue was purified by chromatography (SiCb, C^Cli/methanol 40:1) to give 2.30 g (94 %) 2-methanesulfonyl-5-phenyi-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide as a colorless solid, MS (EI): 517 (M+). Example 3 2-MorphoUn-4-yl-5-phenyl-pyrimidine-4-carboxylicacid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide To a solution of 0.3 g (0.58 mmol) 2-methanesulfonyl-5-phenyl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide in 10 ml dioxan 0.12 ml (1.45 mmol) morpholine was added. The reaction mixture was stirred for 16 hrs. After evaporation of the solvent, the residue was distributed between 50 ml CH2CI2 and 50 ml H2O. The aqueous layer was extracted with 50 ml CH2CI2, the combined organic layers dried (MgS04), filtered and evaporated. The residue was purified by chromatography (SiC>2, CH2Cl2/ethyl acetate 9:1) to give 0.16 g (53%) 2-morpholin-4-yl-5-phenyl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide as a off-white solid, m.p. 154.0-155.0°. Example 4 2-Benzylamino-5-phenyl-pyrimidine-4-carboxylicacid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide To a solution of 0.3 g (0.58 mmol) 2-methanesulfonyl-5-phenyl-pyrimidine-4-carboxylic acid (3,5-bis-trifiuoromethyl-benzyl)-methyl-amide in 10 ml dioxan 0.16 ml (1.45 mmol) benzylamine was added. The reaction mixture was stirred for 16 hrs. After evaporation of the solvent, the residue was distributed between 50 ml CH2C12 and 50 ml H20. The aqueous layer was extracted with 50 ml CH2C12, the combined organic layers dried (MgS04), filtered and evaporated. The residue was purified by chromatography (Si02, CH2Cl2/methanol 50:1) to give 0.14 g (44%) 2-benzylamino-5-phenyl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide as a off-white solid, m.p. 128.5-129.5°. Example 5 2-(4-Methyl-piperazin-l-yl)-5-phenyl-pyrimidine-4-carboxylicacid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide To a solution of 0.3 g (0.58 mmol) 2-methanesulfonyl-5-phenyl-pyrimidine-4-carboxylic acid (3,5-bis-trifiuoromethyl-benzyl)-methyl-amide in 10 ml dioxan 0.16 ml (1.45 mmol) 1-methyl-piperazine was added. The reaction mixture was stirred for 16 hrs. After evaporation of the solvent, the residue was distributed between 50 ml CH2C12 and 50 ml H20. The aqueous layer was extracted with 50 ml CH2C12, the combined organic layers dried (MgS04), filtered and evaporated. The residue was purified by chromatography (Si02, CH2Cl2/MeOH/NH4OH 140:10:1) to give 0.15 g (48%) 2-(4-methyl-piperazin-l-yl)-5-phenyl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide as a off-white solid, m.p. 162.0-162.8°. Example 6 2-(2-Dimethylamino-ethylamino)-5-phenyl-pyrimidine-4-carboxylicacid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide To a solution of 0.3 g (0.58 mmol) 2-methanesulfonyl-5-phenyl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide in 10 ml dioxan 0.16 ml (1.45 mmol) 2-dimethylaminoethylamin was added. The reaction mixture was stirred for 16 hrs. After evaporation of the solvent, the residue was distributed between 50 ml CH2C12 and 50 ml H20. The aqueous layer was extracted with 50 ml CH1CI2, the combined organic layers dried (MgS04), filtered and evaporated. The residue was purified by chromatography (Si02, CH2Cl2/MeOH/NH4OH 130:10:1) to give 0.05 g (16 %) 2-(2-dimethylamino-ethylamino)-5-phenyl-pyrimidine-4-carboxylicacid(3,5-bis-trifluoromethyl-benzyl)-methyl-amide as a off-white solid, m.p. 108.5-109.5°. Example 7 2-Hydroxy-5-phenyl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl) -methyl-amide To a solution of 0.3 g (0.58 mmol) 2-methanesulfonyl-5-phenyl-pyrimidine-4-carboxylic acid (3,5-bis-trifiuoromethyl-benzyl)-methyl-amide in 10 ml dioxan/H20 5 ml 2N NaOH solution was added. The reaction mixture was stirred for 3 hrs. The pH of the reaction solution was than adjusted to 4 with 25% HC1. The aqueous layer was extracted three times with 50 ml CHoCU, the combined organic layers dried (MgS04), filtered and evaporated. The residue was purified by chromatography (SiOi, CH^Ck/methanol 9:1) to give 0.20 g (75%) 2-hydroxy-5-phenyl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide as a off-white solid, m.p. 218.5-219.5°. Example 8 2-Amino-5-phenyl-pyrimidine-4-carboxylic acid (3,5-bis-trifiuoromethyl-benzyl)-methyl-amide To a solution of 0.3 g (0.58 mmol) 2-methanesulfonyl-5-phenyl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide in 20 ml N,N-dimethylformamide a stream of NHj-Gas was introduced during 10 Min. The reaction mixture was poured onto 100 ml HiO. The aqueous layer was extracted three times with 50 ml CH2CI2, the combined organic layers dried (MgS04), filtered and evaporated. The residue was purified by chromatography (Si02, CH2Cl2/MeOH/NH4OH 140:10:1) to give 0.17 g (65%) 2-amino-5-phenyl-pyrimidine-4-carboxylicacid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide as a off-white solid, m.p. 181.5-182.5°. Example 9 2-Methoxy-5-phenyl-pyrimidine-4-carboxylicacid(3,5-bis-trifluoromethyl-benzyl)-methyl-amide To a solution of 0.45 g (0.87 mmol) 2-methanesulfonyl-5-phenyl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide in 15 ml methanol 0.123 g (2.17 mmol) sodiummethanolate (95%) were added at RT and the reaction solution stirred for 12 hrs. The reaction mixture was distibuted between 100 ml H20 and 100 ml CH2CI2. The aqueous layer was extracted three times with 50 ml CH2CI2, the combined organic layers dried (NlgSC^), filtered and evaporated. The residue was purified by chromatography (SiC>2, CHiCU/methanol 40:1) to give 0.30 g (73 %) 2-methoxy-5-phenyl-pyrimidine-4- carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide as a off-white solid, m.p. 97.5-98.5°. Example 10 2-Methyl-5-phenyl-pyTimidine-4-carboxylicacid(3,5-bis-trifluoromethyl-benzyl)-methyl-amide a) 5-Bromo-2-methvl-pvrimidine-4-carboxvlic acid 3>5-bis-trifluoromethvl-benzvlamide To a solution of 2.17 g (10 mmol) 5-Bromo-2-methyl-pyrimidine-4-carboxylic acid 3.18 ml (24 mmol) triethylamin, 1.62 g (12 mmol) 1-hydroxy-benzotriazol and 1.91 g (12 mmol) N-^-dimethylaminopropylJ-N'-ethylcarbodiimide hydrochloride in 100 ml CH2CI2 2.91 g (12 mmol) 3,5-bis-trifluormethyl-benzylamin were added. The reaction mixture was stirred for 16 hrs. The reaction mixture was washed with 100 ml 0.5N HC1 and 100 ml H2O. The aqueous layers were backextracted with 100 ml CHoCli. The combined organic layers were dried (MgS04), filtered and evaporated. The residue was purified by chromatography (SiOi, CH2G2) to give 2.95 g (67 %) 5-bromo-2-methyl-pyrimidine-4-carboxylic acid 3,5-bis-trifluoromethyl-benzylamide as a pale yellow solid. b) 5-Bromo-2-methvl-pvrimidine-4-carboxvlic acid (3,5-bis-trifluoromethvI-benzyl)-methvl-amide To a solution of 2.28 g (5 mmol) 5-bromo-2-methyl-pyrimidine-4-carboxylic acid 3,5-bis-trifluoromethyl-benzylamide in 20 ml N.N-dimethylformamide 0.26 g (5.5 mmol) sodiumhydride (60% dispersion in mineral oil) was added and the reaction mixture stirred for 1 hr. After the addition of 0.4 ml (6.5 mmol) methyl iodide at 0°, the reaction mixture was stirred for 3 hrs. at RT. The reaction mixture was distributed between 80 ml HiO, 80 ml brine and 80 ml CH2CI2. The phases were separated, the aqueous layer washed twice with 80 ml CH2CI2. The combined organic layers were dried (MgSC^), filtered and evaporated. The residue was purified by chromatography (SiC>2, CP^CU/MeOH 19:1) to give 1.98 g (87 %) 5-bromo-2-methyl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide as a waxy solid. c) 2-Methvl-5-phenvl-pvrimidine-4-carboxvlic acid (3,5-bis-trifluoromethvl-benzvl)- methvl-amide To a suspension of 0.456 g (1 mmol) 5-bromo-2-methyl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide, 0.034 g (0.2 mmol) tetrakis-(triphenylphosphin)palladium and 0.121 g (1 mmol) phenylboronic acid in 20 ml 1,2-dimethoxyethane a solution of 0.105 g (1 mmol) Na2C03 in 8 ml H2O was added. The resulting reaction mixture was heated at reflux for 16 hrs. After evaporation of the 1,2- dimethoxyethan, the aqueous phase was extracted twice with 50 ml CH2C12. The combined organic layers were dried (MgS04), filtered and evaporated. The residue was purified by chromatography (Si02, CHiCU/MeOH 40:1) and crystallised (Ethanol) to give 0.258 g (57 %) 2-methyl-5-phenyl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide as off-white crystalls, m.p. 149-152°. Example 11 5-(2-Chloro-phenyl)-2-methylsulfanyl-pyrimidine-4-carboxylicacid(3,5-bis-trifluoromethyl-benzyl)-methyl-amide a) 5-(2-Chloro-phenyl)-2-methvlsulfanvl-pvrimidine-4-carboxvlic acid ethvl ester To a solution of 3.20 g (11.55 mmol) 5-bromo-2-methylsulfanyl-pyrimidine-4-carboxylic acid ethyl ester in 40 ml N.N-dimethylformamid 2.70 g (17.32 mmol) 2-chloro-phenyl-boronic acid, 4.82 ml (34.64 mmol) triethylamin, 0.077 g (0.35 mmol) palladium(II)acetate and 0.167 g (0.72 mmol) triphenylphosphin were added and the resulting reaction mixture heated for 4 hrs. at 105°. The reaction mixture was evaporated and the residue dissolved in 100 ml CH^Ck The organic phase was washed with 80 ml 0.5 N NaOH-Solution, 80 ml H2O and 80 ml brine. The organic phase was dried (MgSC^), filtered and evaporated. The residue was purified by chromatography (SiC>2> CH2CI2) to give 3.00 g (84 %) 5-(2-chloro-phenyl)-2-methylsulfanyl-pyrimidine-4-carboxylic acid ethyl ester a as pale brown oil. b) 5-(2-Chloro-phenvl)-2-methvlsulfanvI-pvrimidine-4-carboxvlicacid To a solution of 3.00 g (9.72 mmol) 5-(2-chloro-phenyl)-2-methylsulfanyl-pyrimidine-4-carboxylic acid ethyl ester in 15 ml ethanol a solution of 0.58 g (14.5 mmol) NaOH in 15 ml was added at RT and the reaction solution was stirred for 1 hr. The pH of the solution was than adjusted to 1 by addition of 25% HC1. The resulting solution was extracted twice with 100 ml CH2CI2 /methanol (2:1). The combined organic phases were dried (MgS04), filtered and evaporated. The residue was suspended in 20 ml diisopropylether, filtered and dried to give 2.40 g (88 %) 5-(2-chloro-phenyl)-2-methylsulfanyl-pyrimidine-4-carboxylic acid a as an off-white solid. c) 5-(2-Chloro-phenvl)-2-methvlsulfanvl-pvrimidine-4-carboxvlic acid (3,5-bis- trifluoromethvl-benzvD-methvl-amide To a suspension of 2.40 g (8.55 mmol) 5-(2-chloro-phenyl)-2-methylsulfanyl-pyrimidine-4-carboxylic acid 2.38 ml (17.1 mmol) triethylamin, 1.30 g (8.55 mmol) 1-hydroxy- benzotriazol and 1.63 g (8.55 mmol) N-tS-dimethylammopropyD-N'-ethylcarbodiimide hydrochloride in 80 ml CH2CI2 2.41 g (8.55 mmol) (3,5-bis-trifluoromethyl-benzyl)-methyl-amine were added. The reaction mixture was stirred for 16 hrs. The reaction mixture was washed with 50 ml 0.5N HC1 and 50 ml H20. The aqueous layers were backextracted with 50 ml CHiCk The combined organic layers were dried (MgS04), filtered and evaporated. The residue was purified by chromatography (Si02, CH2Q2) to give 3.80 g (85 %) 5-(2-chloro-phenyl)-2-methylsulfanyl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide as a white foam, MS (ISP): 520.1 (M+H)+. Example 12 5- (2- Chloro-phenyl) -2-methylsulfonyl-pyrimidine-4-carboxylic acid (3,5-bis-trifiuoromethyl-benzyl)-methyl-arnide To a solution of 3.70 g (7.12 mmol) 5-(2-chloro-phenyl)-2-methylsulfanyl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide in 100 ml CH2CI2 4.38 g (17.8 mmol) 3-chloroperbenzoic acid (70%) was added at 5° and the reaction mixture stirred for 2 hrs. at RT. The solution was washed with 80 ml sat. NaHCOj-soIution, 80 ml diluted NaHSOj-solution and 80 ml H2O. The organic phase was dried (Na2SC>4), filtered and evaporated. The residue was purified by chromatography (Si02> CH2Cl2/MeOH 100:1) to give 3.10 g (97 %) 5-(2-chloro-phenyl)-2-methylsulfonyl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide as a white foam, MS (ISP): 551.9 (M+H)+. Example 13 5-(2-Chloro-phenyl)-2-(4-methyl-piperazin-l-yl)-pyrimidine-4-carboxylicacid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide To a solution of 0.40 g (0.72 mmol) 5-(2-chloro-phenyl)-2-methylsulfonyl-pyrirnidine-4-carboxylic acid (3,5-bis-trifiuoromethyl-benzyl)-methyI-amide in 10 ml dioxan 0.20 ml (1.81 mmol) 1-methyl-piperazine was added. The reaction mixture was stirred for 16 hrs. After evaporation of the solvent, the residue was distributed between 50 ml CH2CI2 and 50 ml HiO. The aqueous layer was extracted with 50 ml CH2C12, the combined organic layers dried (MgSO-j), filtered and evaporated. The residue was purified by 1 chromatography (Si02, CH2Cl2/MeOH/NH4OH 110:10:1) to give 0.37 g (89 %) 5-(2-chloro-phenyl)-2-(4-methyl-piperazin-l-yl)-pyrimidine-4-carboxylicacid(3,5-bis-trifluoromethyl-benzyl)-methyl-amideas a white foam, MS (ISP): 572.1 (M+H+). Example 14 5-(2-Chloro-phenyl)-2-(2-dimethylamino-ethylamino)-pyrimidine-4-carboxylicacid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide To a solution of 0.56 g (0.10 mmol) 5-(2-chloro-phenyl)-2-methylsulfonyl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide in 10 ml dioxan 0.27 ml (2.54 mmol) 2-dimethylaminoethylamin was added. The reaction mixture was stirred for 16 hrs. After evaporation of the solvent, the residue was distributed between 50 ml CH2CI2 and 50 ml H2O. The aqueous layer was extracted with 50 ml CH2CI2, the combined organic layers dried (MgS04), filtered and evaporated. The residue was purified by chromatography (Si02, CH2Cl2/MeOH/NH4OH 140:10:1) to give 0.49 g (86 %) 5-(2-chloro-phenyl)-2-(2-dimethyIamino-ethylamino)-pyrimidine-4-carboxylicacid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide as a white foam, MS (ISP): 560.2 (M+H)+. Example 15 5-(2-Chloro-phenyl)-2-(3-dimethylamino-propoxy)-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide To a solution of 0.5 g (0.91 mmol) 5-(2-chloro-phenyl)-2-methylsulfonyl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide in 20 ml acetonitrile 0.14 ml (1.18 mmol) 2-dimethylamino-propanol and 1.47 g (4.53 mmol) CsiCC^were added. The reaction mixture was stirred for 16 hrs. After evaporation of the solvent, the residue was distributed between 50 ml CH2C12 and 50 ml H20. The aqueous layer was extracted with 50 ml CH2CI2, the combined organic layers dried (MgS04), filtered and evaporated. The residue was purified by chromatography (Si02, CH2Cl2/MeOH/NH4OH 110:10:1) to give 0.40 g (77 %) 5-(2-chloro-phenyl)-2-(3-dimethylamino-propoxy)-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide as a colorless oil, MS (ISP): 575.1 (M+H)+. Example 16 5-(2-Chloro-phenyl)-2-(2-dimethylamino-ethoxy)-pyrimidine-4-carboxylicacid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide To a solution of 0.50 g (0.91 mmol) 5-(2-chloro-phenyl)-2-methylsulfonyl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide in 20 ml acetonitrile 0.118 ml (1.18 mmol) 2-dimethylamino-ethanol and 1.47 g (4.53 mmol) Cs2C03were added. The reaction mixture was stirred for 16 hrs. After evaporation of the solvent, the residue was distributed between 50 ml CH2C12 and 50 ml H20. The aqueous layer was extracted with 50 ml CH2C12, the combined organic layers dried (MgS04), filtered and evaporated. The residue was purified by chromatography (Si02, CH2Cl2/MeOH/NH4OH 110:10:1) to give 0.40 g (77 %) 5-(2-chloro-phenyl)-2-(3-dimethylamino-ethoxy)-pyrimidine-4- carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide as a off-white solid, MS (ISP): 561.3 (M+H)+. Example 17 5-(2-Chloro-phenyl)-2-(2-morpholin-4-yl-ethoxy)-pyrimidine-4-carboxylicacid(3,5-bis-trifluoromethyl-benzyl)-methyl-amid To a solution of 0.50 g (0.91 mmol) 5-(2-chloro-phenyl)-2-methylsulfonyl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide in 20 ml acetonitrile 0.143 ml (1.18 mmol) N-(2-hydroxyethyl)morpholine and 1.47 g (4.53 mmol) CsiCOjwere added. The reaction mixture was stirred for 16 hrs. After evaporation of the solvent, the residue was distributed between 50 ml CH^Cli and 50 ml H20. The aqueous layer was extracted with 50 ml CHiCU, the combined organic layers dried (MgS04), filtered and evaporated. The residue was purified by chromatography (SiC^, CHiCVMeOH/Nr^OH 140:10:1) to give 0.40 g (73 %) 5-(2-chloro-phenyl)-2-(2-morpholin-4-yl-ethoxy)-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide as a off-white foam, MS (ISP): 603.0 (M+H)+. Example 18 2-Methylsulfanyl-5-o-tolyl-pyrimidine-4-carboxylicacid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide In an analogus manner to that described in Example 11a) there was obtained from 5-bromo-2-methylsulfanyl-pyrimidine-4-carboxylic acid ethyl ester and o-tolylboronic acid 2-methylsulfanyl-5-o-tolyl-pyrimidine-4-carboxylic acid ethyl ester, which was saponified as described in Example lib) and reacted with (3,5-bis-trifluoromethyl-benzyl)-methyl-amine to give as described in Example 11 c) 2-methylsulfanyl-5-o-tolyl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide as a white foam, MS (ISP): 500.2 (M+H)+. Example 19 2-Methanesulfonyl-5-o-tolyl-pyrimidine-4-carboxylicacid(3,5-bis-trifluoromethyl-benzyl)-methyl-amide i In an analogous manner to that described in Example 12 there was obtained from 2-methylsulfanyl-5-o-tolyl-pyrimidine-4-carboxylicacid(3,5-bis-trifluoromethyl-benzyl)-methyl-amide and 3-chloroperbenzoic acid 2-methylsulfonyl-5-o-tolyl-pyrimidine-4-carboxylic acid (3,5-bis-trifiuoromethyl-benzyl)-methyl-amide as a white foam, MS (EI): 531 (M+). Example 20 2-(2-Dimethylamino-ethylamino)-5-o-tolyl-pyriniidine-4-carboxylic acid (3,5-bis- trifluoromethyl-benzyl)-rnethyl-amide In an analogous manner to that described in Example 14 there was obtained from 2- methylsulfonyl-5-o-tolyl-pyrimidine-4-carboxylicacid(3,5-bis-trifluoromethyl-benzyl)- methyl-amide and 2-dimethylaminoethylamin 2-(2-dimethylamino-ethylamino)-5-o- tolyl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide as a white foam, MS (ISP): 540.3 (M+H)+. Example 21 2-(2-DimethyIamino-ethoxy)-5-o-tolyl-pyrimidine-4-carboxylicacid(3,5-bis-trifluoromethyl-benzyl)-methyl-amide In an analogous manner to that described in Example 16 there was obtained from 2-methylsulfonyl-5-o-tolyl-pyrimidine-4-carboxylicacid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide and 2-dimethylamino-ethanol 2-(2-dimethylamino-ethoxy)-5-o-tolyl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide as a white foam, MS (ISP): 541.2 (M+H)+, which was treated with HC1 in Ethanol in the in the usual way to give 2-(2-dimethylamino-ethoxy)-5-o-tolyl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide hydrochloride, m.p. 147-149°. Example 22 2-(3-Dimethylamino-propoxy)-5-o-tolyl-pyrimidine-4-carboxylicacid (3,5-bis- trifluoromethyl-benzyl)-methyl-amide In an analogous manner to that described in Example 15 there was obtained from 2- methylsulfonyl-5-o-tolyl-pyrimidine-4-carboxylicacid (3,5-bis-trifluoromethyl-benzyl)- methyl-amide and 2-dimethylamino-propanol 2-(2-dimethylamino-propoxy)-5-o-tolyl- pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide as a white foam, MS (ISP): 555.2 (M+H)+. Example 23 2-Methylsulfanyl-5-naphthalen-l-yl-pyrimidine-4-carboxylicacid (3,5-bis- trifluoromethyl-benzyl)-methyl-amide In an analogous manner to that described in Example 11a) there was obtained from 2- bromo-5-methylsulfanyl-benzoic acid ethyl ester and 1-naphthylboronic acid 2- methylsulfanyl-5-naphmalen-l-yl-pyrimidine-4-carboxylic acid ethyl ester, which was saponified as described in Example lib) and reacted with (3,5-bis-trifiuoromet.hyl- benzyl)-methyl-amine to give as described in Example 11 c) 2-methylsulfanyl-5-naphthalen-l-yl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide as a white foam, MS (EI): 535 (M+). Example 24 2-Methanesulfonyl-5-naphthalen-l-yl-pyrimidine-4-carboxylicacid(3,5-bis- trifluoromethyl-benzyl)-rnethyl-amide In an analogous manner to that described in Example 12 there was obtained from 2- methanesulfanyI-5-naphthalen-l-yl-pyrimidine-4-carboxylicacid (3,5-bis- trifluoromethyl-benzyl)-methyl-amide and 3-chloroperbenzoic acid 2-methanesulfonyl-5- naphthalen-l-yl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl- amide as a white foam, MS (EI): 567 (M+). Example 25 2-(4-Methyl-piperazin- l-yl)-5-naphthalen- l-yl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide In an analogous manner to that described in Example 13 there was obtained from 2-methanesulfonyl-5-naphthalen-l-yl-pyrimidine-4-carboxylicacid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide and 1-methyl-piperazin 2-(4-methyl-piperazin-l-yl)-5-naphthalen-l-yl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide as a white foam, MS (ISP): 588.2(M+H)+. Example 26 2-(2-Dimethylamino-ethylamino)-5-naphthalen-l-yl-pyrimidine-4-carboxylic acid (3,5- bis-trifluoromethyl-benzyl)-methyl-amide In an analogous manner to that described in Example 14 there was obtained from 2- methanesulfonyl-5-naphthalen-l-yl-pyrimidine-4-carbox\'licacid(3,5-bis- trifluoromethyI-benzyl)-methyl-amide and 2-dimethylaminoethylamin 2-(2- dimethylamino-ethylamino)-5-naphthalen-l-yl-pyrimidine-4-carboxylicacid (3,5-bis- trifluoromethyl-benzyl)-methyl-amide as a white foam, MS (ISP): 576.2 (M+H)+. Example 27 2-(2-Dimethylamino-ethoxy)-5-naphthalen- l-yl-pyrimidine-4-carboxylic acid (3,5-bis- trifluoromethyI-benzyl)-methyl-amide In an analogous manner to that described in Example 16 there was obtained from 2- methanesulfonyl-5-naphthalen-l-yl-pyrimidine-4-carboxylicacid(3,5-bis- trifluoromethyl-benzyl)-methyl-amide and 2-dimethylamino-ethanol 2-(2- dimethylamino-ethoxy)-5-naphthalen-1 -yl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyI)-methyl-amide as a white foam, MS (TSP): 576 (M+). Example 28 2-(2-Morpholin-4-yl-ethoxy)-5-naphthalen-l-yl-pyrimidine-4-carboxylicacid(3,5-bis- trifluoromethyl-benzyl)-methyI-amide In an analogous manner to that described in Example 17 there was obtained from 2- methanesulfonyl-5-naphthalen-l-yl-pyrimidine-4-carboxylic acid (3,5-bis- trifluoromethyl-benzyl)-methyl-arnide and N-(2-hydroxyethyl)morpholine 2-(2- morpholin-4-yl-ethoxy)-5-naphthalen-l -yl-pyrimidine-4-carboxylic acid (3,5-bis- trifluoromethyl-benzyl)-methyl-amide as a white foam, MS (ISP): 619.2 (M+H)+. Example 29 2-(3-Dimethylarnino-propoxy)-5-naphthalen-l-yl-pyrirnidine-4-carboxylicacid (3,5-bis- trifluoromethyl-benzyl)-methyl-amide In an analogous manner to that described in Example 15 there was obtained from 2- methanesulfonyl-5-naphthalen-l-yl-pyrimidine-4-carboxylicacid (3,5-bis- trifluoromethyl-benzyl)-methyl-amide and 2-dimethylamino-propanol 2-(2- dimethylamino-propoxy)-5-naphthalen-l-yl-pyrimidine-4-carboxylicacid (3,5-bis- trifluoromethyl-benzyl)-methyl-amide as a white foam, MS (ISP): 591.1 (M+H)+. Example 30 5-(2-Methoxy-phenyl)-2-methylsulfanyl-pyrimidine-4-carboxylicacid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide In an analogous manner to that described in Example 11a) there was obtained from 5-bromo-2-methylsulfanyl-pyrimidine-4-carboxylic acid ethyl ester and 2-methoxy-phenyl boronic acid 5-(2-methoxy-phenyl)-2-methylsulfanyl-pyrimidine-4-carboxylic acid ethyl ester, which was saponified as described in Example lib) and reacted with (3,5-bis-trifiuorornethyl-benzyl)-methyl-amine to give as described in Example lie) 5-(2-methoxy-phenyl)-2-methylsulfanyl-pyrimidine-4-carboxylicacid (3,5-bis-trifiuoromethyl-benzyl)-methyl-amide, MS (EI): 515 (M*). Example 31 2-Methanesulfonyl-5-(2-methoxy-phenyl)-pyrimidine-4-carboxylicacid(3,5-bis-trifluoromethyl-benzyl)-methyl-amide In an analogous manner to that described in Example 12 there was obtained from 2-methanesulfanyl-5-(2-methoxy-phenyI)-pyrimidine-4-carboxylicacid(3,5-bis-trifluoromethyl-benzyl)-methyl-amide and 3-chloroperbenzoic acid 2-methanesulfonyl-5-(2-methoxy-phenyl)-pyrimidine-4-carboxylicacid(3,5-bis-trifluoromethyl-benzyl)-methyl-amide as a white foam, MS (TSP): 547 (M+). Example 32 2- (2-Dimethylamino-ethylamino)-5- (2-methoxy-phenyl)-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide In an analogous manner to that described in Example 14 there was obtained from 2- methanesulfonyl-5-(2-methoxy-phenyl)-pyrimidine-4-carboxylic acid (3,5-bis- trifluoromethyl-benzyl)-rnethyl-amide and 2-dimethylaminoethylamin 2-(2- dimethylamino-ethylamino)-5-(2-methoxy-phenyl)-pyrimidine-4-carboxylic acid (3,5- bis-trifluoromethyl-benzyl)-methyl-amide as a white foam, MS (ISP): 556.1 (M+H)+. Example 33 5-(2-Methoxy-phenyl)-2-(4-methyl-piperazin-l-yl)-pyrimidine-4-carboxylicacid (3,5-bis- trifluoromethyl-benzyl)-methyl-amide In an analogous manner to that described in Example 13 there was obtained from 2- methanesulfonyl-5-(2-methoxy-phenyl)-pyrimidine-4-carboxylicacid (3,5-bis- trifluoromethyl-benzyl)-methyl-amide and 1-methyl-piperazine 5-(2-methoxy-phenyl)-2- (4-methyl-piperazin-l-yl)-pyrimidine-4-carboxylicacid (3,5-bis-trifluoromethyl-benzyl)- methyl-amide as a white foam, MS (ISP): 557.2 (M+H)+. Example 34 2-(2-Dimethylamino-ethoxy)-5-(2-methoxy-phenyl)-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide In an analogous manner to that described in Example 16 there was obtained from 2-methanesulfonyl-5-(2-methoxy-phenyl)-pyrimidine-4-carboxylicacid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide and 2-dimethylaminoethanol 2-(2-dimethylamino-ethoxy)-5-(2-methoxy-phenyl)-pyrimidine-4-carboxylicacid(3,5-bis-trifluoromethyl-benzyl)-methyl-amide as a white foam, MS (ISP): 557.2 (M+H)Example 35 2-(2-Dimethylamino-propoxy)-5-(2-methoxy-phenyl)-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide In an analogous manner to that described in Example 15 there was obtained from 2-methanesulfonyi-5-(2-methoxy-phenyl)-pyrimidine-4-carboxylicacid(3,5-bis-trifluoromethyl-benzyl)-methyl-amide and 2-dimethylaminopropanol 2-(2-dimethylamino-propoxy)-5-(2-methoxy-phenyl)-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide as a white foam, MS (ISP): 571.1 (M+H)+. Example 36 5-(2-Methoxy-phenyl)-2-(2-morpholin-4-yl-ethoxy)-pyrimidine-4-carboxyIic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide In an analogous manner to that described in Example 17 there was obtained from 2-methanesulfonyl-5-(2-methoxy-phenyl)-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide and N-(2-hydroxyethyl)morpholine 5-(2-methoxy-phenyl)-2-(2-morpholin-4-yl-ethoxy)-pyrimidine-4-carboxylicacid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide as a white foam, MS (ISP): 599.1 (M+H)+. Example 37 2-Methylsulfanyl-5-naphthalen-2-yl-pyrimidine-4-carboxylicacid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide In an analogus manner to that described in Example 11a) there was obtained from 5-bromo-2-methylsulfanyl-pyrimidine-4-carboxylic acid ethyl ester and 2-naphthylboronic acid 2-methylsulfanyl-5-naphthalen-2-yl-pyrimidine-4-carboxylic acid ethyl ester, which was saponified as described in Example 11 b) and reacted with (3,5-bis-trifluoromethyl-benzyl)-methyl-amine to give as described in Example lie) 2-methylsulfanyl-5-naphthalen-2-yl-pyrimidine-4-carboxylicacid(3,5-bis-trifluoromethyl-benzyl)-methyl-amide as a white foam, MS (ISP): 536.2 (M+H)+. Example 38 2-Methanesulfonyl-5-naphthalen-2-yl-pyrimidine-4-carboxylicacid (3,5-bis- trifluoromethyl-benzyl)-methyl-amide In an analogous manner to that described in Example 12 there was obtained from 2- methanesulfanyl-5-naphthalen-2-yl-pyrimidine-4-carboxylicacid (3,5-bis- trifluoromethyl-benzyl)-methyl-amide and 3-chloroperbenzoic acid 2-methanesulfonyl-5- naphthalen-2-yl-pyrimidine-4-carboxylicacid (3,5-bis-trifluoromethyl-benzyl)-methyl- amide as a white foam, MS (TSP): 567(M+). Example 39 2-(4-Methyl-piperazin-l-yl)-5-naphthalen-2-yl-pyrimidine-4-carboxylicacid(3,5-bis- trifluoromethyI-benzyI)-methyl-aniide In an analogous manner to that described in Example 13 there was obtained from 2- methanesulfonyl-5-naphthaIen-2-yl-p)Timidine-4-carboxylicacid(3,5-bis- trifluoromethyl-benzyl)-methyl-amide and 1-methylpiperazine 2-(4-methyl-piperazin-l- yl)-5-naphthalen-2-yl-pyrimidine-4-carboxylicacid(3,5-bis-trifluoromethyl-benzyl)- methyl-amide as a white foam, MS (ISP): 588.3 (M+H)+. Example 40 2-(2-Dimemylamino-ethylamino)-5-naphthalen-2-yl-pyrimidine-4-carboxylic acid (3,5- bis-trifluoromethyl-benzyl)-methyl-amide In an analogous manner to that described in Example 14 there was obtained from 2- methanesulfonyl-5-naphthalen-2-yl-pyrimidine-4-carboxylic acid (3,5-bis- trifluoromethyl-benzyl)-methyl-amide and 2-dimethylaminoethylamin 2-(2- dimethylamino-ethylamino)-5-naphthalen-2-yl-pyrimidine-4-carboxylicacid(3,5-bis- trifluoromethyl-benzyl)-methyl-amide as a white foam, MS (ISP): 576.1 (M+H)+. Example 41 2-(2-Dimethylamino-ethoxy)-5-naphthalen-2-yl-pyrimidine-4-carboxylicacid (3,5-bis- trifluoromethyl-benzyl)-methyl-amide In an analogous manner to that described in Example 16 there was obtained from 2- methanesulfonyl-5-naphthalen-2-yl-pyrimidine-4-carboxylicacid (3,5-bis- trifluoromethyl-benzyl)-methyl-amide and 2-dimethylaminoethanol 2-(2- dimethylamino-ethoxy)-5-naphthalen-2-yl-pyrimidine-4-carboxylicacid (3,5-bis- trifluoromethyl-benzyl)-methyl-amide as a white foam, MS (ISP): 577.1 (M+H)*. Example 42 5-(4-Fluoro-phenyl)-2-methylsulfanyl-pyrimidine-4-carboxylicacid (3,5-bis- trifluoromethyl-benzyl)-methyl-amide In an analogus manner to that described in Example 11a) there was obtained from 5- bromo-2-methylsulfanyl-pyrimidine-4-carboxylic acid ethyl ester and 4-fluorboronic acid 5-(4-fluoro-phenyl)-2-methylsulfanyl-pyrimidine-4-carboxylic acid ethyl ester, which was saponified as described in Example 11 b) and reacted with (3,5-bis-trifluoromethyl- benzyl)-methyl-amine to give as described in Example lie) 5-(4-fluoro-phenyl)-2- methylsulfanyl-pyrimidine-4-carboxylic acid (3,5-bis-trifiuoromethyl-benzyl)-methyl-amide as a white foam, MS (EI): 503 (M+). Example 43 5-(4-Fluoro-phenyl)-2-methylsulfonyl-pyrimidine-4-carboxylicacid(3,5-bis-trifiuoromethyl-benzyl)-methyl-amide In an analogous manner to that described in Example 12 there was obtained from 5-(4-fluoro-phenyl)-2-methylsuIfanyl-pyrimidine-4-carboxyIicacid(3,5-bis-trifluoromethyl-benzyl) -methyl-amide and 3-chloroperbenzoic acid 5-(4-fluoro-phenyl)-2-methylsulfonyl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide as a white foam, MS (EI): 535 (M+). Example 44 2-(3-Dimethylamino-propoxy)-5-(4-fluoro-phenyl)-pyTimidine-4-carboxylicacid (3,5- bis-trifluoromethyl-benzyl)-methyl-amide In an analogous manner to that described in Example 15 there was obtained from 5-(4- fluoro-phenyl)-2-methylsulfonyl-pyrimidine-4-carboxylicacid(3,5-bis-trifluoromethyl- benzyl)-methyl-amide and 2-dimethylaminopropanol 2-(3-dimethylamino-propoxy)-5- (4-fluoro-phenyl)-pyrimidine-4-carboxylicacid(3,5-bis-trifluoromethyl-benzyl)-methyl- amide as a white foam, MS (ISP): 559.3 (M+H)+. Example 45 2-(2-Dimethylamino-ethoxy)-5-(4-fluoro-phenyl)-pyrimidine-4-carboxylicacid(3,5-bis- trifluoromethyl-benzy])-methyl-amide In an analogous manner to that described in Example 16 there was obtained from 5-(4- fluoro-phenyl)-2-methylsulfonyl-pyrimidine-4-carboxylicacid (3,5-bis-trifluoromethyl- benzyl)-methyl-amide and 2-dimethylaminoethanol 2-(3-dimethylamino-ethoxy)-5-(4- fluoro-phenyl)-pyrimidine-4-carboxylicacid (3,5-bis-trifluoromethyl-benzyl)-methyl- amide as a white foam, MS (ISP): 545.2 (M+H)+. Example 46 2-(2-Dimemylammo-emylamino)-5-(4-fluoro-phenyl)-pyrimidine-4-carboxylic acid (3,5- bis-trifluoromethyl-benzyl)-methyl-amide In an analogous manner to that described in Example 14 there was obtained from 5-(4- fluoro-phenyl)-2-methylsulfonyl-pyrimidine-4-carboxylicacid (3,5-bis-trifluoromethyl- benzyl)-methyl-amide and 2-dimethylaminoethylamin 2-(3-dimethylamino-ethylamino)- 5-(4-fluoro-phenyl)-pyrimidine-4-carboxylicacid(3,5-bis-trifluoromethyl-ben2yl)-methyl-amide as a white foam, MS (ISP): 544.2 (M+H)+. Example 47 5-(4-Fluoro-phenyl)-2-(2-morpholin-4-yl-ethoxy)-pyrimidine-4-carboxylicacid(3,5-bis- trifluoromethyl-benzyl)-methyl-amide In an analogous manner to that described in Example 17 there was obtained from 5-(4- fluoro-phenyl)-2-methylsulfonyl-pyrimidine-4-carboxylicacid (3,5-bis-trifluoromethyl- benzyl)-methyl-amide and N-(2-hydroxyethyl)morpholine 5-(4-fluoro-phenyl)-2-(2- morpholin-4-yl-ethoxy)-pyrimidine-4-carboxylicacid (3,5-bis-trifluoromethyl-benzyl)- methyl-amide as a white foam, MS (ISP): 587.2 (M+H)+. Example 48 5-(4-Fluoro-2-methyl-phenyl)-2-methylsulfanyl-pyrimidine-4-carboxylicacid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide In an analogus manner to that described in Example 11a) there was obtained from 5-bromo-2-methylsulfanyI-pyrimidine-4-carboxylic acid ethyl ester and 4-fluoro-2-methyl -phenyl boronic acid 5-(4-fluoro-2-methyl-phenyl)-2-methylsulfanyl-pyrimidine-4-carboxylic acid ethyl ester, which was saponified as described in Example lib) and reacted with (3,5-bis-trifluoromethyl-benzyl)-methyl-amine to give as described in Example lie) 5-(4-fluoro-2-methyl-phenyl)-2-methylsulfanyl-pyrimidine-4-carboxylicacid(3,5-bis-trifluoromethyl-benzyl)-methyl-amide as a white foam, MS (EI): 517 (M+). Example 49 5-(4-Fluoro-2-methyl-phenyl)-2-methylsulfonyl-pyrimidine-4-carboxylicacid (3,5-bis- trifluoromethyl-benzyl)-methyl-amide In an analogous manner to that described in Example 12 there was obtained from 5-(4- fluoro-2-methyl-phenyl)-2-methylsulfanyl-pyrimidine-4-carboxylicacid (3,5-bis- trifluoromethyl-benzyl)-methyl-amide and 3-chloroperbenzoic acid 5-(4-fluoro-2-methyl- phenyl)-2-methylsulfonyl-pyrimidine-4-carboxylicacid(3,5-bis-trifluoromethyl-benzyl)- methyl-amide as a white foam, MS (EI): 549 (M+). Example 50 5-(4-Fluoro-2-methyl-phenyl)-2-(2-morpholin-4-yl-ethoxy)-pyrimidine-4-carboxylicacid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide In an analogous manner to that described in Example 17 there was obtained from 5-(4-fluoro-2-methyl-phenyl)-2-methylsulfonyl-pyrimidine-4-carboxylicacid(3,5-bis-trifluoromethyl-benzyl)-methyl-amide and N-(2-hydroxyethyl)morpholine 5-(4-fluoro-2-methyl-phenyl)-2-(2-morpholin-4-yl-ethoxy)-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide as a white foam, MS (ISP): 601.1 (M+H)+. Example 51 2-(3-Dimethylarm^o-propoxy)-5-(4-fluoro-2-memyl-phenyl)-pyrirnidine-4-carboxylic acid(3,5-bis-trifluoromethyl-benzyl)-methyl-amide In an analogous manner to that described in Example 15 there was obtained from 5-(4- fluoro-2-methyl-phenyl)-2-methylsulfonyl-pyrimidine-4-carboxylicacid (3,5-bis- trifluoromethyl-benzyl)-methyl-amide and 2-dimethylaminopropanol 2-(3- dimethylamino-propoxy)-5-(4-fluoro-2-methyl-phenyl)-pyrimidine-4-carboxylicacid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide as a white foam, MS (ISP): 573.1 (M+H)+. Example 52 2-(2-Dimethylanuno-ethoxy)-5-(4-fluoro-2-methyl-phenyl)-pyrirnidine-4-carboxylicacid (3,5-bis-trifluoromethyI-benzyI)-methyl-amide In an analogous manner to that described in Example 16 there was obtained from 5-(4- fluoro-2-methyl-phenyl)-2-methylsulfony]^pyrirhidine-4-carboxylicacid(3,5-bis- trifluoromethyl-benzyl)-methyl-amide and 2-dimethylaminoethanol 2-(3-dimefhylamino- ethoxy)-5-(4-fluoro-2-methyI-phenyl)-pyrimidine-4-carboxylicacid (3,5-bis- trifluoromethyl-benzyl)-methyl-amide as a white foam, MS (ISP): 559.2 (M+H)Example 53 5-(4-Fluoro-2-methyl-phenyl)-2-(4-methyl-piperazin-l-yl)-pyrimidine-4-carboxylicacid (S.S-bis-trifluoromethyl-benzy^-methyl-amide In an analogous manner to that described in Example 13 there was obtained from 5-(4- fluoro-2-methyl-phenyl)-2-methylsulfonyl-pyrimidine-4-carboxylicacid(3,5-bis- trifluoromethyl-benzyl)-methyl-amide and 1-methyl-piperazine 5-(4-fluoro-2-methyl- phenyl)-2-(4-methyl-piperazin-l-yl)-pyrimidine-4-carboxylic acid (3,5-bis- trifluoromethyl-benzyl)-methyl-amide as a white foam, MS'(ISP): 570.2 (M+H)+. Example 54 2-(2-Dimethylamino-ethylamino)-5-(4-fluoro-2-methyl-phenyl)-pyrimidine-4-carboxylic acid(3,5-bis-trifluoromethyl-benzyl)-methyl-amide In an analogous manner to that described in Example 14 there was obtained from 5-(4-fluoro-2-methyl-phenyl)-2-methylsulfonyl-pyrimidine-4-carboxylicacid(3,5-bis-trifluoromethyl-benryl)-methyl-amide and 2-dimethylaminoethylamin 2-(2- dimethylamino-ethylamino)-5-(4-fluoro-2-methyl-phenyl)-pyrimidine-4-carboxylicacid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide as a white foam, MS (ISP): 558.3 (M+H)+. Example 55 5-(2-Chloro-phenyl)-2-hydroxymethyl-pyrimidine-4-carboxylicacid(3,5-bis-trifluoromethyl-benzyl)-methyl-amide a) 5-Bromo-2-hvdroxvmethvl-pvrimidine-4-carboxvlic acid ethvl ester A solution of 4.2 g (18.02 mmol) 5-bromo-2-hydroxymethyl-pyrimidine-4-carboxylic acid in 50 ml 5N HCl/EtOH was stirred for 5 hrs. at RT. After evaporation of the solvent the residue was distributed between 50 ml CH2CI2 and 30 ml H20. The organic phase was washed with sat. NaHC03 and brine. The combined organic phases were dried (Na2S04), filtered and evaporated. The residue was purified by chromatography to give 3.80 g (80 %) 5-bromo-2-hydroxymethyl-pyrimidine-4-carboxylic acid ethyl ester as a pale yellow solid. b) 5-(2-Chloro-phenvl)-2-hvdroxvmethvl-pyrimidine-4-carboxvlic acid ethyl ester To a solution of 3.70 g (14.17 mmol) 5-bromo-2-hydroxymethyl-pyrimidine-4-carboxylic acid ethyl ester in 50 ml N,N-dimethylformamide 3.32 g (21.6 mmol) 2-chloro-phenyl-boronic acid, 5.92 ml (42.52 mmol) triethylamine, 0.095 g (0.43 mmol) palladium(II)acetate and 0.223 g (0.85 mmol) triphenylphosphine were added and the resulting reaction mixture heated for 4 hrs. at 105°. The reaction mixture was evaporated and the residue dissolved in 100 ml CH2CI2. The organic phase was washed with 80 ml 0.5 N NaOH-Solution, 80 ml H2O and 80 ml brine. The organic phase was dried (MgS04), filtered and evaporated. The residue was purified by chromatography (Si02, CHiCWethyl acetate) to give 3.40 g (82 %) 5-(2-chloro-phenyl)-2-hydroxymethyl-pyrimidine-4-carboxylic acid ethyl ester a as pale brown oil. c) 5-(2-Chloro-phenvl)-2-hvdroxvmethvl-pvrimidine-4-carboxylicacid To a solution of 3.40 g (11.6 mmol) (2-chloro-phenyl)-2-hydroxymethyl-pyrimidine-4-carboxylic acid ethyl ester in 15 ml ethanol 0.69 g (17.42 mmol) NaOH in 15 ml H2O was added and the mixture stirred for 1 hr. The pH of the solution was adjusted to 1 and the solid was filtered off to give after drying 2.80 g (91 %) 5-(2-chloro-phenyl)-2-hydroxymethyl-pyrimidine-4-carboxylic acid as a pale brown solid. d) 5-(2-Chloro-phenvI)-2-hvdroxvmethvI-pvrimidine-4-carboxvlic acid (3,5-bis-trifluoromethvI-benzvD-methvI-amide To a suspension of 2.80 g (10.58 mmol) 5-(2-chloro-phenyl)-2-hydroxymethyl-pyrimidine-4-carboxylic acid in 70 ml CH2C12 2.94 ml (21.2 mmol) triethylamin, 1.62 g (10.58 mmol) 1-hydroxy-benzotriazol and 2.02 g (10.58 mmol) N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride 2.99 g (11.64 mmol) (3,5-bis-trifluoromethyl-benzyl)-methyl-amine were added. The reaction mixture was stirred for 16 hrs. The reaction mixture was washed with 50 ml 0.5N HC1 and 50 ml H^O. The aqueous layers were backextracted with 50 ml CH2C12. The combined organic layers were dried (MgSCj), filtered and evaporated. The residue was purified by chromatography (Si02, CH2Cl2/MeOH 19:1) to give 3.80 g (71 %) 5-(2-chloro-phenyl)-2-hydroxymethyl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide as a pale brown oil, MS (ISP): 504.2 (M+H+). Example 56 5-(2-Chloro-phenyl)-2-(4-memyl-piperazin-l-ylmethyl)-pyrimidine-4-carboxylicacid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide a) Methanesulfonic acid 4-ff3,5-bis-trifluoromethvl-benzvl)-methyI-carbamovl]-5-(2- chloro-phenvl)-pvrimidin-2-vlmethvl ester and 2-Chloromethvl-5-(2-chloro-phenvl)- pvrimidine-4-carboxvlic acid (3,5-bis-trifluoromethvl-benzvl)-methyl-amide To a solution of 3.80 g (7.54 mmol) 5-(2-chloro-phenyl)-2-hydroxymethyl-pyrimidine-4-carboxylic acid (3,5-bis-trifiuoromethyl-benzyl)-methyl-amide and 1.57 ml (11.31 mmol) triethylamine in 80 ml CHUCK 0.645 ml (8.30 mmol) methansulfonylchloride were added at 0°. The reaction mixture was stirred for 16 hrs. The reaction mixture was poured onto sat. NaHCCV solution and extracted three times with 50 ml CH2C12. The combined organic layers were dried (MgS04), filtered and evaporated. The residue was purified by chromatography (Si02, CH2Cl2/ethyl acetate 8:1) to give 2.70 g (61 %) methanesulfonic acid4-[(3,5-bis-trifluoromethyl-benzyl)-methyl-carbamoyl]-5-(2-chloro-phenyl)-pyrimidin-2-ylmethyl ester as a pale brown oil, MS (ISP): 582.0 (M+H+) and 0.90 g (22%) 2-chloromethyl-5-(2-chloro-phenyl)-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide as a pale brown oil, MS (ISP): 522.1 (M+H+). b) 5-(2-Chloro-phenvl)-2-(4-methvI-piperazin-l-vlmethvl)-pyrimidine-4-carboxvlicacid (3,5-bis-trifluoromethvl-benzvD-methvl-amide To a solution of 0.39 g (0.75 mmol) 2-chloromethyl-5-(2-chloro-phenyl)-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide in 10 ml CH2C12 0.20 ml (1.87 mmol) N-methylpiperazine were added. The reaction mixture was stirred for 16 hrs. at RT and than poured into H20 and extracted three times with 50 ml CH2Ck The combined organic layers were dried (MgS04), filtered and evaporated. The residue was purified by chromatography (Si02, CH2Cl2/MeOH/NH4OH 110:10:1) to give 0.27 g (61 %) 5-(2-chloro-phenyl)-2-(4-methyl-piperazin-l-ylmethyl)-pyrimidine-4-carboxylicacid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide as a colorless oil, MS (ISP): 586.1 (M+H+). Example 57 5-(2-Chloro-phenyl)-2-morpholin-4-ylmethyl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-ben2yl)-methyl-amide To a solution of 0.58 g (1.11 mmol) 2-chloromethyl-5-(2-chloro-phenyl)-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-arnide in 10 ml CH2C12 0.24 ml (2.78 mmol) morpholine were added. The reaction mixture was stirred for 16 hrs. at RT and than poured into H20 and extracted three times with 50 ml CH2CI?. The combined organic layers were dried (MgS04), filtered and evaporated. The residue was purified by chromatography (Si02, CH2Cl2/MeOH/NH4OH 200:10:1) to give 0.40 g (62 %) 5-(2-chloro-phenyl)-2-morpholin-4-ylmethyl-p}oimidine-4-carboxylicacid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide as a colorless foam, MS (ISP): 573.1 (M+H+). Example 58 5-(2-Chloro-phenyl)-2-[(2-dimethylamino-ethylamino)-methyl]-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide To a solution of 0.62 g (1.07 mmol) methanesulfonic acid 4-[(3,5-bis-trifluoromethyl-benzyl)-methyl-carbamoyl]-5-(2-chloro-phenyl)-pyrimidin-2-ylmethyl ester in 10 ml CH2C12 0.29 ml (2.66 mmol) 2-dimethylyminoethylamine were added. The reaction mixture was stirred for 16 hrs. at RT and than poured into H20 and extracted three times with 50 ml CH2C12. The combined organic layers were dried (MgS04), filtered and evaporated. The residue was purified by chromatography (Si02, CH2Cl2/MeOH/NH40H 110:10:1) to give 0.22 g (36 %) 5-(2-chloro-phenyl)-2-[(2-dimethylamino-ethylamino)-methyl]-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide as a colorless oil, MS (ISP): 574.1 (M+H+). Beispiel 59 5- (2-CUoro-phenyl)-2-dimethylaminomethyl-pyrimidine-4-carboxylic acid (3,5-bis-trifiuoromethyl-benzyl) -methyl-amide To a solution of 0.62 g (1.07 mmol) methanesulfonic acid 4-[(3,5-bis-trifluoromethyl-benzyl)-methyl-carbamoyl]-5-(2-chloro-phenyl)-pyrimidin-2-ylmethyl ester in 10 ml CH2CI21.53 ml (8.52 mmol) of a 5.6 M solution of dimethylamine were added. The reaction mixture was stirred for 16 hrs. at RT and than poured into H20 and extracted three times with 50 ml CH2CI2. The combined organic layers were dried (MgS04), filtered and evaporated. The residue was purified by chromatography (SiOi, CH2Cl2/MeOH/NH4OH 200:10:1) to give 0.40 g (70 %) 5-(2-chloro-phenyl)-2-dimethylaminomethyl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide as a colorless oil, MS (ISP): 531.1 (M+H+). Example 60 2-Methylsulfanyl-5-o-tolyl-pyrimidine-4-carboxylicacid(3,5-dimethyl-benzyl)-methyl-amide To a suspension of 0.30 g (1.15 mmol) 2-methylsulfanyl-5-o-tolyl-pyrimidine-4-carboxylic acid in 20 ml CH2C12,0.32 ml (2.3 mmol) triethylamine, 0.17 g (1.15 mmol) 1-hydroxy-benzotriazole and 0.22 g (1.15 mmol) N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride 0.20 g (1.38 mmol) (3,5-dimethyl-benzyl)-methyl-amine were added. The reaction mixture was stirred for 16 hrs. The reaction mixture was washed with 50 ml 0.5N HC1 and 50 ml H2O. The aqueous layers were backextracted with 50 ml CH2CI2. The combined organic layers were dried (MgSC^), filtered and evaporated. The residue was purified by chromatography (Si02, CH2CI2) to give 0.36 g (79 %) 2-methylsulfanyl-5-o-tolyl-pyrimidine-4-carboxylic acid (3,5-dimethyl-benzyl)-methyl-amide as a white foam, MS (EI): 391 (M+). Example 61 2-Methanesulfonyl-5-o-tolyl-pyrimidine-4-carboxylicacid(3,5-dimethyl-benzyl)-methyl-amide To a solution of 0.36 g (0.92 mmol) 2-methylsulfanyl-5-o-tolyl-pyrimidine-4-carboxylic acid (3,5-dimethyl-benzyl)-methyl-amide in 20 ml CH2CI2 0.56 g (0.23 mmol) 3-chloroperbenzoic acid (70%) was added at 5° and the reaction mixture stirred for 3 hrs. at RT. After addition of 50 ml sat. NaHC03-solution, the layers were separated, the organic phase washed with sat. NaHC03-solution, dried (Na2S04), filtered and evaporated. The residue was purified by chromatography (Si02, Cr^CWMeOH 40:1) to give 0.29 g (74 %) 2-methanesulfonyl-5-o-tolyl-pyrimidine-4-carboxylicacid(3,5-dimethyl-benzyl)-methyl-amide as a colorless foam, MS (EI): 423 (M+). Example 62 2-(4-Methyl-piperazm-l-yl)-5-o-tolyl-pyrirnidine-4-carboxylicacid(3,5-dimethyl-benzyl)-methyl-amide To a solution of 0.28 g (0.66 mmol) 2-methanesulfonyl-5-o-tolyl-pyrimidine-4-carboxylic acid (3,5-dimethyl-benzyl)-methyl-amide in 10 ml dioxane 0.18 ml (1.65 mmol) 1-methylpiperazine was added. The reaction mixture was stirred for 16 hrs. After evaporation of the solvent, the residue was distributed between 50 ml CH2CI2 and 50 ml H2O. The aqueous layer was extracted with 50 ml CH2Q2, the combined organic layers dried (MgSC^), filtered and evaporated. The residue was purified by chromatography (Si02, CH2Cl2/MeOH/NH4OH 110:10:1) to give 0.18 g (61 %) 2-(4-methyl-piperazin-l-yl)-5-o-tolyl-pyrimidine-4-carboxylic acid (3,5-dimethyl-benzyl)-methyl-amide as a colorless foam, MS (ISP): 444.5 (M+H+). Example 63 2-Morpholin-4-yl-5-o-tolyl-pyrimidine-4-carboxylicacid (3,5-dimethyl-benzyl)-methyl-amide To a solution of 0.21 g (0.49 mmol) 2-methanesulfonyl-5-o-tolyl-pyrimidine-4-carboxylic acid (3,5-dimethyl-benzyl)-methyl-amide in 10 ml dioxane 0.13 ml (1.48 mmol) morpholine was added. The reaction mixture was stirred for 16 hrs. After evaporation of the solvent, the residue was distributed between 50 ml CH2CI2 and 50 ml H2O. The aqueous layer was extracted with 50 ml CH2CI2, the combined organic layers dried (MgS04), filtered and evaporated. The residue was purified by chromatography (SiO:, CH2Cl2/MeOH 100:1) to give 0.17 g (78 %) 2-morpholin-4-yl-5-o-tolyl-pyrimidine-4-carboxylic acid (3,5-dimethyl-benzyl)-methyl-amide as a colorless foam, MS (ISP): 431.5 (M+H+). Example 64 2-Methylsulfanyl-5-o-tolyl-pyrimidine-4-carboxylicacid (3,5-dimethoxy-benzyl)-methyl-amide To a suspension of 0.30 g (1.15 mmol) 2-methylsulfanyl-5-o-tolyl-pyrimidine-4-carboxylic acid in 20 ml CH2C12,0.32 ml (2.3 mmol) triethylamine, 0.17 g (1.15 mmol) 1-hydroxy-benzotriazole and 0.22 g (1.15 mmol) N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride 0.25 g (1.38 mmol) (3,5-dimethoxy-benzyl)-methyl-amine were added. The reaction mixture was stirred for 16 hrs. The reaction mixture was washed with 50 ml 0.5N HC1 and 50 ml H20. The aqueous layers were backextracted with 50 ml CH2C12. The combined organic layers were dried (MgS04), filtered and evaporated. The residue was purified by chromatography (Si02, CH2Cl2/MeOH 40:1) to give 0.45 g (92 %) 2-methylsulfanyl-5-o-tolyl-pyrimidine-4-carboxyIic acid (3,5-dimethyoxy-benzyl)-methyl-amide as a white foam, MS (EI): 423 (M+). Example 65 2-Memanesulfonyl-5-o-tolyl-pyrimidine-4-carboxylicacid(3,5-dimethoxy-benzyl)-methyl-amide To a solution of 0.45 g (1.06 mmol) 2-methylsulfanyl-5-o-tolyl-pyrimidine-4-carboxylic acid (3,5-dimethyoxy-benzyl)-methyl-amide in 20 ml CH2C12 0.65 g (0.26 mmol) 3-chloroperbenzoic acid (70%) was added at 5° and the reaction mixture stirred for 3 hrs. at RT. After addition of 50ml sat. NaHCCVsolution, the layers were separated, the organic phase washed with sat. NaHCCVsolution, dried (Na2S04), filtered and evaporated. The residue was purified by chromatography (Si02, CH2Cl2/MeOH 40:1) to give 0.20 g (41 %) 2-methanesulfonyl-5-o-tolyl-pyrimidine-4-carboxylicacid (3,5-dimethyoxy-benzyl)-methyl-amide as a colorless foam, MS (EI): 455 (M+). Example 66 2-(4-Methyl-piperazin-l-yl)-5-o-tolyl-pyrimidine-4-carboxylicacid(3,5-dimethoxy-benzyl) -methyl-amide To a solution of 0.18 g (0.4 mmol) 2-methanesulfonyl-5-o-tolyl-pyrimidine-4-carboxylic acid (3,5-dimethoxy-benzyl)-methyl-amide in 10 ml dioxane 0.11 ml (0.99 mmol) 1-methylpiperazine was added. The reaction mixture was stirred for 16 hrs. After evaporation of the solvent, the residue was distributed between 50 ml CH2C12 and 50 ml H20. The aqueous layer was extracted with 50 ml CH2C12) the combined organic layers dried (MgS04), filtered and evaporated. The residue was purified by chromatography (Si02, CH2Cl2/MeOH/NH4OH 110:10:1) to give 0.16 g (85 %) 2-(4-methyl-piperazin-l-yl)-5-o-tolyl-pyrimidine-4-carboxylic acid (3,5-dimethoxy-benzyl)-methyl-amide as a colorless foam, MS (ISP): 476.3 (M+H+). Example 67 2-Methylsulfanyl-5-o-tolyl-pyrimidine-4-carboxylicacid3,5-dichloro-benzylamide To a solution of 1.2 g (4.6 mmol) 2-methylsulfanyl-5-o-tolyl-pyrimidine-4-carboxylic acid in 30 ml CH2C121.28 ml (9.2 mmol) triethylamine, 0.62 g (4.6 mmol) 1-hydroxy-benzotriazole and 0.88 g (4.6 mmol) N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide at RT. The rection mixture was distributed between 50 ml H20, 50 ml brine and 50 ml CH2C12. The phases were separated and the aqueous layer washed twice with 50 ml CH2C12. The combined organic layers were dried (MgS04), filtrered and evaporated. The residue was purified by chromatography (Si02, CH2Cl2/ethyl acetate 40:1) to give 0.57 g (92 %) 2- methylsulfanyl-5-o-tolyl-pyrimidine-4-carboxylicacid(3,5-dichloro-benzyl)-methyl-amide as a colorless oil, MS (ISP): 432.2,434.2 (M+H+). Example 71 2-Methylsulfonyl-5-o-tolyl-pyrimidine-4-carboxylicacid(3,5-dichloro-benzyl)-methyl-amide To a solution of 0.57 g (1.31 mmol) methylsulfanyl-5-o-tolyl-pyrimidine-4-carboxylic acid (3,5-dichloro-benzyl)-methyl-amide in 50 ml CH2C12 0.81 g (3.29 mmol) 3-chloroperbenzoic acid (70%) was added at 5° and the reaction mixture stirred for 3 hrs. at RT. After addition of 40 ml sat. NaHCO.i-solution, the layers were separated, the organic phase washed with sat. NaHCCVsolution, dried (Na2S04), filtered and evaporated. The residue was purified by chromatography (Si02, CH2Cl2/MeOH 100:1) to give 0.58 g (94 %) 2-methylsulfonyl-5-o-tolyl-pyrimidine-4-carboxylicacid (3,5-dichloro-benzyl)-methyl-amide as a colorless foam, MS (EI): 463,465 (M+). Example 72 2-(4-Methyl-piperazin-l-yl)-5-o-tolyl-pyrimidine-4-carboxylicacid (3,5-dichloro-benzyl)-methyl-amide To a solution of 0.25 g (0.538 mmol) 2-methylsulfonyl-5-o-tolyl-pyrimidine-4-carboxylic acid (3,5-dichloro-benzyl)-methyl-amide in 5 ml dioxane 0.15 ml (1.34 mmol) 1-methylpiperazine was added. The reaction mixture was stirred for 16 hrs. After evaporation of the solvent, the residue was distributed between 25 ml CH2C12 and 25 ml H20. The aqueous layer was extracted with 20 ml CH2C12, the combined organic layers dried (MgS04), filtered and evaporated. The residue was purified by chromatography (Si02, CH2Cl2/MeOH/NH4OH) 9:1) to give 0.116 g (44 %) 2-(4-methyl-piperazin-l-yl)-5-o-tolyl-pyrimidine-4-carboxylic acid (3,5-dichloro-benzyl)-mediyl-amide as a colorless oil, MS (ISP): 484.3,486.3 (M+H+). Example 73 2-(3>5-Bis-trifluoromethyl-phenyl)-N-methyl-N-(2-methylsulfanyl-5-o-tolyl-pyrimidin-4- yl)-isobutyramide a) (2-Methvlsulfanyl-5-o-tolvl-pvrimidin-4-vl)-carbamic acid tert.-butvl ester To a solution of 2.29 g (8.8 mmol) 2-methylsuIfanyl-5-o-tolyl-pyrimidine-4-carboxylic acid, 1.26 ml triethylamine (8.8 mmol) and 1.66 ml (17.6 mmol) butyl alcohol in 30 ml THF, 1.90 ml (8.8 mmol) diphenylphosphorylazide were added and the resulting solution heated at reflux for 12 hrs. After evaporation of the solvent, the residue was distributed between CH2C12 and H20. The aqueous phase was extracted twice with CH2C12. The combined organic layers were dried (Na2S04), filtered and evaporated. The residue was purified by chromatography (Si02, CH2Cl2/ethyl acetate 19:1) to give 2.45 g (84%) (2-methylsulfanyl-5-o-tolyl-pyrimidin-4-yl)-carbamic acid ter.-butyl ester as a colorless solid, MS(TSP):331(M+). b) Methvl-f2-methvlsulfanvl-5-o-tolvl-pvrimidin-4-vl)-carbamic acid tert.-butvl ester To a solution of 2.45 g (7.40 mmol) (2-methylsulfanyl-5-o-tolyl-pyrimidin-4-yl)-carbamic acid tert.-butyl ester in 30 ml N,N-dimethylformamide 0.44 g (11.09 mmol) sodiumhydride (60% dispersion in mineraloil) was added and the reaction mixture stirred for 1 hr. After the addition of 0.74 ml (11.83 mmol) methyl iodide at 0°, the reaction mixture was stirred for 3 hrs. The reaction mixture was distributed between 75 ml H20, 75 ml brine and 75 ml CH2CI2. The phases were separated, the aqueous layer washed twice with 75 ml CH2C12. The combined organic layers were dried (Na2SC>4), filtered and evaporated. The residue was purified by chromatography (Si02, CH2C12/ethyl acetate 19:1) to give 2.50 g (98 %) methyl-(2-methylsulfanyl-5-o-tolyl-pyrimidin-4-yl)-carbamic acid tert.-butyl ester as a colorless oil, MS (TSP): 345 (M+). c) Methvl-(2-methvlsulfanvl-5-o-tolyl-pvrimidin-4-vl)-amine A solution of 2.66 g (7.7 mmol) methyl-(2-methylsulfanyl-5-o-tolyl-pyrimidin-4-yl)-carbamic acid tert-butyl ester in 30 ml MeOH/HCl (2N) was stirred at 50° for 3 hr. After evaporation of the solvent, the residue was distributed between 40 ml IN NaOH and 40 ml CH2C12. The phases were separated, the aqueous layer washed twice with 50 ml CH2C12. The combined organic layers were dried (Na2S04), filtered and evaporated. The residue was purified by chromatography (Si02, CH2C12) to give 1.48 g (78 %) methyl-(2-methylsulfanyl-4-o-tolyl-pyrimidin-5-yl)-amine as a white solid, MS (EI): 245 (M+). d) 2-(3,5-Bis-trifluoromethvl-phenvl)-N-methvl-N-f2-methvlsulfanvl-5-o-tolvl- pvrimidin-4-vI)-isobutyramide To a solution of 1.48 g (6.0 mmol) methyl-(2-methylsulfanyl-4-o-tolyl-pyrimidin-5-yl)-amine in 10 ml N,N-dimethylformamide 6.4 ml of a 1M solution potassiumhexamethyldisilazide (6.4 mmol) in THF were added at 0°. After lh, 2.3 g (7.22 mmol) (2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride in 5 ml THF were added and the reaction mixture stirred for 24 hrs. at RT. The reaction mixture was poured onto 50 ml 0.5 N NaOH-solution. After addition of ethyl acetate the phases were separated, the aqueous layer washed twice with 50 ml ethyl acetate. The combined organic layers were dried (Na2SC>4), filtered and evaporated. The residue was purified by chromatography (Si02, CH2Cl2/ethyl acetate 10:1) to give 1.20 g (37 %) 2-(3,5-bis-trifluoromethyl-phenyl)-N-methyl-N-(2-methylsuifanyl-5-o-tolyl-pyrimidin-4-yl)-isobutyramide as a white foam, MS (ISP): 528.2 (M+H+). Example 74 2-(3,5-Bis-trifluoromemyl-phenyl)-N-(2-methanesulfonyl-5-o-toIyl-pyrimidin-4-yl)-N-methyl-isobutyramide To a solution of 1.20 g (2.27 mmol) 2-(3,5-bis-trifluoromethyl-phenyl)-N-methyl-N-(2-methylsulfanyl-5-o-tolyl-pyrimidin-4-yl)-isobutyramide in 50 ml CH2C121.46 g (5.91 mmol) 3-chloroperbenzoic acid (70%) was added at 5° and the reaction mixture stirred for 3 hrs. at RT. After addition of 100 ml sat. NaHCOj-solution, the layers were separated, the organic phase washed with sat. NaHCOj-solution, dried (Na2S04), filtered and evaporated. The residue was purified by chromatography (Si02, CH2C12) to give 1.10 g (86 %)2-(3,5-bis-trifluoromethyI-phenyI)-N-(2-methanesulfonyl-5-o-tolyl-pyrimidin-4-yl)-N-methyl-isobutyramide as a colorless foam, MS (EI): 559 (M+H+). Example 75 2-(3,5-Bis-trifluoromethyl-phenyl)-N-methyl-N-[2-(4-methyl-piperazin-l-yl)-5-o-tolyl-pyrimidin-4-yI]-isobutyramide To a solution of 0.2 g (0.36 mmol) 2-(3,5-bis-trifiuoromethyl-phenyl)-N-(2-methanesulfonyl-5-o-tolyl-pyrimidin-4-yl)-N-methyl-isobutyramide in 10 ml dioxan 0.09 ml (0.89 mmol) 1-methylpiperazine was added. The reaction mixture was stirred for 16 hrs. After evaporation of the solvent, the residue was distributed between 50 ml CH2C12 and 50 ml H20. The aqueous layer was extracted with 50 ml CH2C12, the combined organic layers dried (MgS04), filtered and evaporated. The residue was purified by chromatography (Si02, CH2Cl2/MeOH/NH4OH 140:10:1) to give 0.08 g (36 %) 2-(3,5-bis-trifluoromethyl-phenyl)-N-methyl-N-[2-(4-methyl-piperazin-l-yl)-5-o-tolyl-pyrimidin-4-ylj-isoburyramide as a colorless foam, MS (ISP): 580.1(M+H+). Example 76 2-(3,5-Bis-trifluoromethyl-phenyl)-N-methyl-N-(2-piperazin-l-yl-5-o-tolyl-pyrimidin-4- yl)-isob utyramide To a solution of 0.2 g (0.36 mmol) 2-(3,5-bis-trifluoromethyl-phenyl)-N-(2-methanesulfonyl-5-o-tolyl-pyrimidin-4-yI)-N-methyl-isobutyramide in 10 ml dioxane 0.1 g (0.89 mmol) piperazine was added. The reaction mixture was stirred for 16 hrs. After evaporation of the solvent, the residue was distributed between 50 ml CH2C12 and 50 ml H20. The aqueous layer was extracted with 50 ml CH2C12, the combined organic layers dried (MgS04), filtered and evaporated. The residue was purified by chromatography (Si02, CH2Cl2/MeOH/NH4OH 110:10:1) to give 0.18 g (89 %) 2-(3,5-bis-trifluoromethyl-phenyl)-N-methyl-N-(2-piperazin-l-yl-5-o-tolyl-pyrimidin'4-yl)-isobutyramideasa colorless foam, MS (ISP):556.2 (M+H+). Example 77 2-(3,5-Bis-trifluoromethyl-phenyl)-N-methyl-N-(2-morpholin-4-yl-5-o-tolyl-pyrimidin-4-yl)-isobutyramide To a solution of 0.2 g (0.36 mmol) 2-(3,5-bis-trifluoromethyl-phenyl)-N-(2-methanesulfonyl-5-o-tolyl-pyrimidin-4-yl)-N-methyl-isobutyramide in 10 ml dioxane 0.08 g (0.89 mmol) morpholine was added. The reaction mixture was stirred for 16 hrs. After evaporation of the solvent, the residue was distributed between 50 ml CH2C12 and 50 ml H20. The aqueous layer was extracted with 50 ml CH2C12, the combined organic layers dried (MgSCU), filtered and evaporated. The residue was purified by chromatography (Si02, CH2Cl2/MeOH 90:1) to give 0.18 g (89 %) 2-(3,5-bis-trifluoromethyl-phenyl)-N-methyl-N-(2-morpholin-4-yl-5-o-tolyl-pyrimidin-4-yl)-isobutyramide as a colorless foam, MS (ISP): 567.2 (M+H+). Example 78 2-(3,5-Bis-trifluoromethyl-phenyl)-N-[2-(2-dimethylamino-ethylamino)-5-o-tolyl-pyrimidin-4-yl]-N-methyl-isobutyramide To a solution 0.2 g (0.36 mmol) 2-(3,5-bis-trifluoromethyl-phenyl)-N-(2-methanesulfonyl-5-o-tolyl-pyrimidin-4-yl)-N-methyl-isobutyramide in 10 ml dioxan 0.09 ml (0.89 mmol) 2-dimethylaminoethylamin was added. The reaction mixture was stirred for 16 hrs. After evaporation of the solvent, the residue was distributed between 50 ml CH2C12 and 50 ml H20. The aqueous layer was extracted with 50 ml CH2C12, the combined organic layers dried (MgSCU), filtered and evaporated. The residue was purified by chromatography (Si02, CH2Cl2/MeOH/NH4OH 140:10:1) to give 0.15 g (77 %) 2-(3,5-bis-trifluoromethyl-phenyl)-N-[2-(2-dimethylamino-ethylamino)-5-o-tolyl-pyrimidin-4-yl]-N-methyl-isobutyramide as a colorless foam, MS (ISP): 568.3 (M+H+). Beispiel 79 2-(3,5-Bis-trifluoromethyl-phenyl)-N-[2-(2-dimethylamino-ethoxy)-5-o-tolyl-pyrimidin-4-yl] -N-methyl-isobutyramide To a solution of 0.3 g (0.54 mmol) 2-(3,5-bis-trifluoromethyl-phenyl)-N-(2-methanesulfonyl-5-o-tolyl-pyrimidin-4-yl)-N-methyl-isobutyramide in 10 ml acetonitrile 0.08 ml (0.8 mmol) 2-dimethylamino-ethanol and 0.97 g (2.68 mmol) Cs2C03 were added. The reaction mixture was stirred for 16 hrs. After evaporation of the solvent, the residue was distributed between 40 ml CH2C12 and 40 ml H20. The aqueous layer was extracted with 40 ml CH2C12, the combined organic layers dried (MgS04), filtered and evaporated. The residue was purified by chromatography (Si02, CH2Cl2/MeOH/NH4OH 140:10:1) to give 0.27 g (88 %) 2-(3,5-bis-trifluoromethyl-phenyl)-N-[2-(2-dimethylamino-ethoxy)-5-o-tolyl-pyrimidin-4-yl]-N-methyl-isobutyramide as a colorless solid, MS (ISP): 569.2 (M+H+). Example 80 2-(3,5-Bis-txifluoromemyl-phenyl)-N-[5-(2-chloro-phenyl)-2-methylsulfanyl-pyrimidin-4-yl] -N-methyl-isobutyramide a) f5-(2-Chloro-phenyl)-2-methylsulfanvl-pvrimidin-4-vl1-carbamic acid tert.-butvl ester To a solution of 2.50 g (8.9 mmol) 5-(2-chloro-phenyl)-2-methylsulfanyl-pyrimidine-4-carboxylic acid, 1.24 ml triethylamine (8.9 mmol) and 1.67 ml (17.8 mmol) butyl alcohol in 30 ml THF, 1.91 ml (8.9 mmol) diphenylphosphorylazide were added and the resulting solution heated at reflux for 12 hrs. After evaporation of the solvent, the residue was distributed between CH2C12 and H20. The aqueous phase was extracted twice with CH2C12. The combined organic layers were dried (NaiSC^), filtered and evaporated. The residue was purified by chromatography (Si02, CH2Cl2/ethyl acetate 19:1) to give 2.20 g (70%) [5-(2-chloro-phenyl)-2-methylsulfanyl-pyrimidin-4-yl]-carbamic acid tert.-butyl ester as a colorless solid, MS (EI): 351 (M+). b) [5-(2-Chloro-phenvl)-2-methylsulfanvl-pvrimidin-4-vn-methvl-carbamic acid tert.- butvl ester To a solution of 2.0 g (5.68 mmol) [5-(2-chloro-phenyl)-2-methylsulfanyl-pyrimidin-4-yl]-carbamic acid tert.-butyl ester in 30 ml N.N-dimethylformamide 0.34 g (8.53 mmol) sodiumhydride (60% dispersion in mineraloil) was added and the reaction mixture stirred for 1 hr. After the addition of 0.56 ml (9.09 mmol) methyl iodide at 0°, the reaction mixture was stirred for 3 hrs. The reaction mixture was distributed between 75 ml H20, 75ml brine and 75 ml CH2C12. The phases were separated, the aqueous layer washed twice with 75 ml CH2C12. The combined organic layers were dried (Na2S04), filtered and evaporated. The residue was purified by chromatography (Si02, CH2Cl2/ethyl acetate 19:1) to give 2.0 g (96 %) [5-(2-chJoro-phenyl)-2-methylsulfanyl-pyrimidin-4-yl]-methyl-carbamic acid tert.-butyl ester as a pale yellow oil, MS (EI): 365 (M+). c) f5-(2-Chloro-phenvl)-2-methvlsulfanvl-pvrimidin-4-vn-methvl-amine A solution of 2.40 g (6.5 mmol) [5-(2-chloro-phenyl)-2-methylsulfanyl-pyrimidin-4-yl]-methyl-carbamic acid tert-butyl ester in 30 ml MeOH/HCl (2N) was stirred at 55° for 3 hrs. After evaporation of the solvent, the residue was distributed between 40 ml IN NaOH and 40 ml CH2C12. The phases were separated, the aqueous layer washed twice with 50 ml CH2C12. The combined organic layers were dried (Na2S04), filtered and evaporated. The residue was purified by chromatography (Si02, CH2Cl2/ethyl acetate 19:1) to give 1.70 g (97 %) [5-(2-chloro-phenyl)-2-methylsulfanyl-pyrimidin-4-yl]-methyl-amine as a white solid, MS (EI): 265 (M+). d) 2-(3,5-Bis-trifluoromethvl-phenvl)-N-[5-(2-chloro-phenvl)-2-methvlsulfanvl- pyrimidin-4-vn-N-methvl-isobutvramide To a solution of 0.70 g (2.6 mmol) [5-(2-Chloro-phenyl)-2-methylsulfanyl-pyrimidin-4-yl]-methyl-amine in 4 ml N,N-dimethylformamide 2.6 ml of a 1M solution potassiumhexamethyldisilazide (2.6 mmol) in THF were added at 0°. After lh, 0.92 g (2.6 mmol) (2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride in 2 ml THF were added and the reaction mixture stirred for 24 hrs. at RT. The reaction mixture was poured onto 50 ml 0.5 N NaOH-solution. After addition of ethyl acetate the phases were separated, the aqueous layer washed twice with 50 ml ethyl acetate. The combined organic layers were dried (Na2S04), filtered and evaporated. The residue was purified by chromatography (Si02, CH2Cl2/ethyl acetate 19:1) to give 0.85 g (58 %) 2-(3,5-bis-trifluoromethyl-phenyl)-N-[5-(2-chloro-phenyl)-2-methylsulfanyl-pyrimidin-4-yl]-N-methyl-isobutyramideasa white foam, MS (EI): 547 (M+). Example 81 2-(3,5-Bis-trifluoromethyl-phenyl)-N-[5-(2-chloro-phenyl)-2-methanesulfonyl-pyrimidin-4-yl]-N-methyl-isobutyramide To a solution of 0.8 g (1.64 mmol) 2-(3,5-bis-trifluoromethyl-phenyl)-N-[5-(2-chloro-phenyl)-2-methylsulfanyl-pyrimidin-4-yl]-N-methyl-isobutyramide in 50 ml CH2C12 0.89 g (3.65 mmol) 3-chloroperbenzoic acid (70%) was added at 5° and the reaction mixture stirred for 3 hrs. at RT. After addition of 100 ml sat. NaHC03-solution, the layers were separated, the organic phase washed with sat. NaHCCb-solution, dried (Na2S04)> filtered and evaporated. The residue was purified by chromatography (Si02, CH2Cl2/ethyl acetate) to give 0.73 g (86 %) 2-(3,5-bis-trifluoromethyl-phenyl)-N-[5-(2-chloro-phenyl)-2-methanesulfonyI-pyrimidin-4-yl]-N-methyl-isobutyrarnide as a colorless foam, MS (ISP):580.0 (M+H+). Example 82 2-(3,5-Bis-trifluoromethyl-phenyl)-N-[5-(2-chloro-phenyl)-2-(4-methyl-piperazin-l-yl)-pyrimidin-4-yl]-N-methyl-isobutyramide To a solution of 0.3 g (0.52 mmol) 2-(3,5-bis-trifluoromethyl-phenyl)-N-[5-(2-chloro-phenyl)-2-methanesulfonyl-pyrimidin-4-yl]-N-methyl-isobutyramide in 10 ml dioxane 0.14 ml (1.29 mmol) 1-methylpiperazine was added. The reaction mixture was stirred for 16 hrs. After evaporation of the solvent, the residue was distributed between 50 ml CH2CI2 and 50 ml H2O. The aqueous layer was extracted with 50 ml CH2CI2, the combined organic layers dried (MgS04), filtered and evaporated. The residue was purified by chromatography (Si02, Cr^CWMeOH/NH-jOH 140:10:1) to give 0.25 g (80 %) 2-(3,5-bis-trifluoromethyl-phenyl)-N-[5-(2-chloro-phenyl)-2-(4-methyl-piperazin-l-yl)-pyrimidin-4-ylj-N-methyl-isobutyramide as a colorless foam, MS (ISP): 600.1 (M+H+). Example 83 2-(3,5-Bis-trifluoromethyl-phenyl)-N-[5-(2-chloro-phenyl)-2-(2-dimethylamino-ethylamino)-pyrimidin-4-yl]-N-methyl-isobutyramide To a solution of 0.4 g (0.69 mmol) 2-(3,5-bis-trifluoromethyl-phenyl)-N-[5-(2-chloro-phenyl)-2-methanesulfonyl-pyrimidin-4-yl]-N-methyl-isobutyramide in 10 ml dioxane 0.19 ml (1.72 mmol) 2-dimethylaminoethylamin was added. The reaction mixture was stirred for 16 hrs. After evaporation of the solvent, the residue was distributed between 50 ml CH2CI2 and 50 ml H2O. The aqueous layer was extracted with 50 ml CH2CI2, the combined organic layers dried (MgSO.i)> filtered and evaporated. The residue was purified by chromatography (Si02, CH2Cl2/MeOH/NH4OH 110:10:1) to give 0.30 g (74 %) 2-(3,5-bis-trifluoromethyl-phenyl)-N-[5-(2-chloro-phenyl)-2-(2-dimethylamino-ethylamino)-pyrimidin-4-yl]-N-methyl-isobutyramide as a colorless foam, MS (ISP): 588.2 (M+H+). The active substance, lactose and corn starch are firstly mixed in a mixer and then in a comminuting machine. The mixture is returned to the mixer, the talc is added thereto and mixed thoroughly. The mixture is filled by machine into hard gelatine capsules. The suppository mass is melted in a glass or steel vessel, mixed thoroughly and cooled to 45°C. Thereupon, the finely powdered active substance is added thereto and stirred until it has dispersed completely. The mixture is poured into suppository moulds of suitable size, left to cool, the suppositories are then removed from the moulds and packed individually in wax paper or metal foil. WE CLAIM: 1. Compounds of the general formula wherein R1 is hydrogen or halogen; R" is hydrogen, halogen, lower alkyl or lower alkoxy; R3 is halogen, trifluoromethyl, lower alkoxy or lower alkyl; R4/R4 are independently from each other hydrogen or lower alkyl; R5 is lower alkyl, lower alkoxy, amino, hydroxy, hydroxy-lower alkyl, -(CH;>)n-piperazinyI, optionally substituted by lower alkyl, -(CH2)n-morpholinyl,-(CH2)ntrimidazolyl,-0-(CH2)n+i-morpholinyl, -0-(CH2)nti-piperidinyl, lower alkyl-sulfanyl, lower alkyl-sulfonyl, benzylamino, -NH-(CH2)n+1N(R4'h, -(CH:)n-NH-(CH2)ntlN(Rr:h, -(CH2)„+1N(Rr')2, or -0-(CH2)ntiN(R ):, wherein R is hydrogen or lower alkyl; R6 is hydrogen; R: and R6 or R1 and R6 may be together with the two carbon ring atoms -CH=CH-CH=CH-, with the proviso that n for R1 is 1; n is independently 0 - 2; and X is -C(0)N(R4"')- or -N(R4")C(0)-; or pharmaceutical^ acceptable acid addition salts thereof. 2. A compound according to claim 1, wherein X is -C(0)N(R4')-, R4" is methyl and R5 is -(CH2)n-piperazinyl, otionally substituted by methyl and n is 0 or 1. 3. A compound according to claim 2, which is 5-(2-chloro-phenyl)-2-(4-methyl-piperazin-l-yl)-pyrimidine-4-carboxylicacid(3,5-bis-trifluoromethyl-benzyl)-methyl-amide, 5-(4-fluoro-2-methyl-phenyl)-2-(4-methyl-piperazin-1 -yl)-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide or 5-(2-chloro-phenyl)-2-(4-methyl-piperazin-l-ylmethyl)-pyrimidine-4-carboxylicacid (3,5-bis-trifluoromethyl-benzyI)-methyl-amide. 4. A compound according to claim 1, in which X is -C(0)N(R4 )-> R4 is methyl and R5 is -0(CH2)2-morpholinyl. 5. A compound according to claim 4, which is 5-(2-chloro-phenyl)-2-(2-morpholin-4-yl-ethoxy)-pyrimidine-4-carboxyiicacid(3,5-bis-trifluoromethyl-benzyl)-methyl-amid. 6. A compound according to claim 1, in which X is -C(0)N(R4 )-, R4 is methyl and R5 is-NH(CH2)n+iN(CH3)2> -(CH2)n-NH(CH2)n+iN(CH3)2 or -0(CH2)n+,N(CH3)2, wherein n is 1 or 2, 7. A compound according to claim 6, which is 5-(2-chloro-phenyI)-2-(2-dimethylamino-ethylamino)-pyrimidine-4-carboxylic acid (3,5- bis-trifluoromethyl-benzyl)-methyl-amide, 2-(2-dimethylamino-ethylamino)-5-o-tolyl-pyrimidine-4-carboxylic acid (3,5-bis- trifluoromethyl-benzyty-rnethyl-amide, 2-(2-dimethylamino-ethylamino)-5-(2-methoxy-phenyl)-pyrimidine-4-carboxylicacid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide, 2-(2-dimethylamino-ethylamino)-5-(4-fluoro-phenyl)-pyrimidine-4-carboxylic acid (3,5- bis-trifluoromethyl-benzyl)-methyl-amide, 2-(2-dimethylamino-ethylamino)-5-(4-fluoro-2-methyl-phenyl)-pyrimidine-4-carboxylic acid (S.S-bis-trifluoromethyl-benzyO-methyl-amide, 5-(2-chIoro-phenyl)-2-(3-dimethylamino-propoxy)-pyrimidine-4-carboxylicacid(3,5-bis- trifluoromethyl-benzyl)-methyl-amide, 5-(2-chloro-phenyl)-2-(2-dimethylamino-ethoxy)-pyrimidine-4-carboxylicacid(3,5-bis- trifluoromethyl-benzyl)-methyl-amide, 2-(2-dimethylamino-ethoxy)-5-o-tolyl-pyrimidine-4-carboxylicacid (3,5-bis- trifluoromethyl-benzyl)-methyl-arnide, 2-(3-dimethylamino-propoxy)-5-o-tolyl-pyrimidine-4-carboxylicacid (3,5-bis- trifluoromethyl-benzyl)-methyl-amide, 2-(2-dimethylamino-propoxy)-5-(2-methoxy-phenyl)-pyrimidine-4-carboxylicacid (3,5- bis-trifluoromethyl-benzyl)-methyl-amide, 2-(3-dimethylamino-propoxy)-5-(4-fluoro-2-methyl-phenyl)-pyrimidine-4-carboxylic acid (S.S-bis-trifluoromethyl-benzyO-methyl-amide, 2-(2-dimethyIamino-ethoxy)-5-(4-fluoro-2-methyI-phenyl)-pyrimidine-4-carboxyIicacid (3,5-bis-trifluoromethyl-benzyl)-methyl-amideor 5-(2-chloro-phenyl)-2-[ (2-dimethylamino-ethylamino)-methyl ]-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide. 8. A compound according to claim 1, wherein X is -CON(R4 )j, R4 is methyl and R5 is SCH3. 9. A compounds in accordance with claim 8, which is 2-methylsulfanyl-5-o-tolyl-pyrirnidine-4-carboxylicacid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide or 5-(4-fluoro-2-methyl-phenyl)-2-methylsulfanyl-pyrimidine-4-carboxylicacid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide. 10. A compound according to claim 1, wherein X is -CON(R4 ):, R4 is methyl and R2 and R6 or Rl and R6 are together with the two carbon ring atoms -CH=CH-CH=CH-. 11. A compound in accordance with claim 10, which is 2- (4-methyl-piperazin-1 -yl)-5-naphthalen-1 -yl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide, 2-(2-dimethylamino-ethylamino)-5-naphthalen- l-yl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide, 2-(2-dimethylamino-ethoxy)-5-naphthalen-l-yl-pyTimidine-4-carboxylic acid (3,5-bis- trifluoromethyl-benzyl)-methyl-arriide, 2-(2-morpholin-4-yl-ethoxy)-5-naphthalen-l-yl-pyrimidine-4-carboxylic acid (3,5-bis- trifluoromethyl-benzyl)-methyl-amideor 2-(3-dimethylamino-propoxy)-5-naphthalen-l-yl-pyrimidine-4-carboxylicacid(3,5-bis- trifluoromethyl-benzyl)-methyI-amide. 12. A compound according to claim 1, wherein X is X is -N(R4 )C(0)-, R4 is lower alkyl and R5 is -(CH2)n-piperazinyl, optionally substituted by lower alkyl, -(CH2)„-morpholinyl, -NH-(CH2)„+1N(CH3)2 or -0-(CH2)n+1N(CH3)2.. 13. A compound in accordance with claim 12, which is 2-(3,5-bis-trifluoromethyl-phenyl)-N-methyl-N-[2-(4-methyl-piperazin-l-yl)-5-o-tolyl-pyrimidin-4-yl] -isobutyramide, 2-(3,5-bis-trifluoromethyl-phenyl)-N-methyl-N-(2-piperazin-l-yl-5-o-tolyl-pyrimidin-4-yl) -isobutyramide, 2-(3,5-bis-trifluoromethyl-phenyl)-N-methyl-N-(2-morpholin-4-yl-5-o-tolyl-pyrimidin-4-yl)-isobutyramide, 2-(3,5-bis-trifluoromethyl-phenyl)-N-[2-(2-dimethylamino-ethylamino)-5-o-tolyl-pyrimidin-4-yl ] -N-methyl-isobutyramide, 2-(3,5-bis-trifluoromethyl-phenyl)-N-[2-(2-dimethylamino-ethoxy)-5-o-tolyl-pyrimidin-4-yl] -N-methyl-isobutyramide, 2-(3,5-bis-trifluoromethyl-phenyl)-N-[5-(2-chloro-phenyl)-2-(4-methyl-piperazin-l-yI)-pyrimidin-4-yl] -N-methyl-isobutyramide or 2-(3,5-bis-trifluoromethyl-phenyl)-N-[5-(2-chloro-phenyl)-2-(2-dimethylamino-ethylamino)-pyrimidin-4-yl ] -N-methyl-isobutyramide 14. A medicament containing one or more compounds as claimed in any one of claims 1-13 and pharmaceutically acceptable excipients. 15. A process for preparing a compound of formula I as defined in claim 1, which process comprises a) reacting a compound of formula wherein R'-R5 and n have the significances given in claim 1, or c) modifying one or more substituents R'-R3 within the definitions given above, and if desired, converting the compound obtained into a pharmaceutically acceptable acid addition salt. 16. A compound according to any one of claims 1-13, whenever prepared by a process as claimed in claim 14.

Documents:

in-pct-2001-1649-che abstract.pdf

in-pct-2001-1649-che claims duplicate.pdf

in-pct-2001-1649-che claims.pdf

in-pct-2001-1649-che correspondence-others.pdf

in-pct-2001-1649-che correspondence-po.pdf

in-pct-2001-1649-che description (complete) duplicate.pdf

in-pct-2001-1649-che description (complete).pdf

in-pct-2001-1649-che form-1.pdf

in-pct-2001-1649-che form-18.pdf

in-pct-2001-1649-che form-26.pdf

in-pct-2001-1649-che form-3.pdf

in-pct-2001-1649-che form-5.pdf

in-pct-2001-1649-che pct search report.pdf

in-pct-2001-1649-che pct.pdf

in-pct-2001-1649-che petition.pdf