| Title of Invention | N-SUBSTITUTED NONARYL-HETEROCYCLIC NMDA/NR2B ANTAGONISTS |
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| Abstract | TITLE OF THE INVENTION N-SUBSTITUTED NONARYL-HETEROCYCLIC NMDA/NR2B ANTAGONISTS Compounds represented by Formula (I): (I) or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain. |
| Full Text | We claim: 1 A compound having the formula (I): (I) or a pharmaceutically acceptable salt thereof, wherein NonAr is piperidine ring; HetAr is a 6 membered Iheteroaromatic ring containing 2 nitrogen ring atoms; HetAr is optionally substituted with I or 2 substituents, each substituent independently is CMalkyl^ CMalkoxy, C2-4aIkynyl, trifluoromethyl, hydroxy, hydroxyCi^alkyl, fluoro, chloro, bromo, iodo, cyano, methylsulfanyl, cyclopropylethynyl-, phenylethynyH heteroaryleth3myI-,-N(Co-4alkyl)(Co-4alkyl), nitro, (Ci-2aIkyl)(Ci.2alkyl)NCH2- CCl-2alkyl)HNCH2- Si(CH3)3~C- or NH2C(0)- A is methylene; B is aryl(CH2)o.3-0-CCOH and X is H, OH, F, Cl-4alkyl, Ci-4alkoxy, NH2, or X taken with an adjacent bond is =0. 2. The compound as claimed in claim 1, wherein said compound is: 6. A pharmaceutical composition comprising an inert carrier and an amount of a compound according to claim 1 effective to treat pain. |
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1316-chenp-2003 abstract duplicate.pdf
1316-chenp-2003 claims duplicate.pdf
1316-chenp-2003 description (complete) duplicate-1.pdf
1316-chenp-2003 description (complete) duplicate-2.pdf
1316-chenp-2003 description (complete) duplicate.pdf
1316-chenp-2003-correspondnece-others.pdf
1316-chenp-2003-correspondnece-po.pdf
1316-chenp-2003-description(complete).pdf
| Patent Number | 223179 | |||||||||||||||||||||||||||||||||
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| Indian Patent Application Number | 1316/CHENP/2003 | |||||||||||||||||||||||||||||||||
| PG Journal Number | 47/2008 | |||||||||||||||||||||||||||||||||
| Publication Date | 21-Nov-2008 | |||||||||||||||||||||||||||||||||
| Grant Date | 05-Sep-2008 | |||||||||||||||||||||||||||||||||
| Date of Filing | 22-Aug-2003 | |||||||||||||||||||||||||||||||||
| Name of Patentee | MERCK & CO., INC. | |||||||||||||||||||||||||||||||||
| Applicant Address | 126 EAST LINCOLN AVENUE, RAHWY, NJ 07065-0907 | |||||||||||||||||||||||||||||||||
Inventors:
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| PCT International Classification Number | C07D401/12 | |||||||||||||||||||||||||||||||||
| PCT International Application Number | PCT/US02/05226 | |||||||||||||||||||||||||||||||||
| PCT International Filing date | 2002-02-20 | |||||||||||||||||||||||||||||||||
PCT Conventions:
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