Title of Invention

PYRIDODIAZINES COMPOUND AND A PROCESS FOR PREPARING THE SAME

Abstract

The present invention relates to the compound of the general formula (I); wherein Wand X, Wand Z, X and Y or Y and Z are N and the other two are CR<SUP>8</SUP> ; R<SUP>8</SUP> is H, halo, C<SUB>I-4</SUB> alkyl, C<SUB>I-4</SUB> alkoxy or halo(C<SUB>I-4</SUB> )alkyl; R is halo; - R<SUP>1</SUP> is halo, C<SUB>I-8</SUB> alkyl, C<SUB>2-8</SUB> alkenyl, C<SUB>2-8</SUB> alkynyl, C<SUB>3-8</SUB> cycloalkyl, C<SUB>3-8</SUB> cycJoalkyl(C<SUB>I-6</SUB> )alkyl, C<SUB>I-8</SUB> alkoxy, Clog alkylthio, aryl, aryloxy, arylthio, heteroaryl, heteroaryloxy, heteroarylthio, aryl(C<SUB>I-4</SUB> )alkyl, aryl(C<SUB>I-4</SUB> )alkoxy, heteroaryl(C<SUB>I-4</SUB> )alkyl, heteroaryl(C<SUB>I-4</SUB> )alkoxy, aryl(C<SUB>I-4</SUB> )alkylthio, heteroaryl(C<SUB>I-4</SUB> )alkylthio, morpholino, piperidino or pyrrolidino; R<SUP>2</SUP> is NR<SUP>3</SUP> R<SUP>4</SUP>; R<SUP>3</SUP> and R<SUP>4</SUP> are independently H, C<SUB>I-8</SUB> alkyl, C<SUB>2-8</SUB> alkenyl, C<SUB>2-8</SUB> alkynyl, aryl, aryl(C<SUB>I-8</SUB>)alkyl, C<SUB>3-8</SUB> cycloalkyl, C<SUB>3-8</SUB> cycloalkyl(C<SUB>I-6</SUB> )alkyl, heteroaryl, heteroaryl(C<SUB>I-8</SUB> )alkyl, NR<SUP>5</SUP>R<SUP>6</SUP>, provided that not both R<SUP>3</SUP> and R<SUP>4</SUP> are H or NR<SUP>5</SUP> R<SUP>6</SUP>, or R<SUP>3</SUP> and R<SUP>4</SUP> together form a C3-7 alkylene or C3-7 alkenylene chain substituted or unsubstituted with one or more C<SUB>I-4</SUB> alkyl or C<SUB>I-4</SUB> alkoxy groups, or, together with the nitrogen atom to which they are attached, R<SUP>3</SUP> and R<SUP>4</SUP> form a morpholine, thiomorpholine, thiomorpholine S-oxide or thiomorpholine S-dioxide ring or a piperazine or piperazine N-(C<SUB>I-4</SUB> )alkyl (especially N-rnethyl) ring; and R<SUP>5</SUP> and R<SUP>6</SUP> are independently H, Clog alkyl, C<SUB>2-8</SUB> alkenyl, C<SUB>2-8</SUB> alkynyl, aryl, aryl(C<SUB>I-8</SUB> )alkyl, , C<SUB>3-8</SUB> cycloalkyl, C<SUB>3-8</SUB> cycloalkyl(C<SUB>I-6</SUB> )alkyl, heteroaryl or heteroaryl(C<SUB>I-8</SUB> )alkyl; any of the foregoing alkyl, alkenyl, alkynyl or cycloalkyl groups or moieties (other than for R<SUP>8</SUP> ) being substituted or unsubstituted with halogen, cyano, C<SUB>I-6</SUB> alkoxy, C<SUB>I-6</SUB> alkylcarbonyl, C<SUB>I-6</SUB> alkoxycarbonyl, C<SUB>I-6</SUB> haloalkoxy, C<SUB>I-6</SUB> alkylthio, tri(C<SUB>I-4</SUB> )alkylsilyl, C<SUB>I-6</SUB> alkylamino or C<SUB>I-6</SUB> dialkylamino, any of the foregoing morpholine, thiomorpholine, piperidine, piperazine and pyrrolidine rings being' substituted or unsubstituted with C<SUB>I-4</SUB> alkyl (especially methyl), and

Full Text

PYRIDODIAZINES AS PLANT FUNGICIDES This invention relates to novel derivatives of pyridopyrazines and pyridopyridazines, to processes for preparing them, to certain intermediate chemicals used in their manufacture, to compositions containing them and to methods of using them to combat fungi, especially fungal infections of plants. Derivatives of the nitrogen-containing 5,6 ring system s--,2,4-triazolo[l,5-a1pyri-midine are known from the patent literature as being useful for controlling phytopathogenic fungi. Examples of recent patent publications include EP-A-1249452, WO 02/051845, WO 02/083676, WO 02/083677, WO 02/088125, WO 02/088126, WO 02/088127. Condensed nitrogen heterocycles used as antimycotics are known from US 5821244. Derivatives of pyridopyrazines are known in the chemical literature, for example from J. Med Chem. (1968), 11(6), 1216-18, J. Med. Chem. (1970), 13(5), 853-7 and US 3984412, but not for agrochemical purposes. The present invention is concerned with the provision of novel pyridopyrazines and pyridopyridazines for combating phytopathogenic diseases on plants and harvested food crops. Thus, according to the present invention, there is provided a compound of the general formula (1): that not both R3 and R4 are H or NR5R6, or R3 and R4 together foR"" a C3-7 alkylene or C3.7 alkenylene chain optionally substituted with one or more C1-4alkyl or C1-4alkoxy groups, or, 1 A together with the nitrogen atom to which they are attached, R and R foR"" a morpholine, thiomorpholine, thiomorpholine S-oxide orthiomorpholine S-dioxide ring or a piperazine or piperazine (especially TV-methyl) ring; and R5 and R6 are independently H, C1-8alkyl, C2-8 alkenyl, C2-8 alkynyl, aryl, aryl(Ci-8)alkyl, C3-8 cycloalkyl,C3-8 cycloalkyl(C1-6)alkyl, heteroaryl or heteroaryl(C1-8)alkyl; any of the foregoing alkyl, alkenyl, alkynyl or cycloalkyl groups or moieties (other than for R ) being optionally substituted with halogen, cyano, Cj-e alkoxy, C1-6alkylcarbonyl, C1-6alkoxycarbonyl, C1-6 haloalkoxy, C1-6 alkylthio, tri(CM)alkylsilyl, C1-6 alkylamino or C1-6 dialkylamino, any of the foregoing morpholine, thiomorpholine, piperidine, piperazine and pyrrolidine rings being optionally substituted with C1-4alkyl (especially methyl), and any of the foregoing aryl or heteroaryl groups or moieties being optionally substituted with one or more substituents selected from halo, hydroxy, mercapto, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C2-6 alkenyloxy, C2-6 alkynyloxy, halo(C1-6)alkyl, halo(C1-6)alkoxy, C1-6 alkylthio, halo(C1-6)alkylthio, hydroxy(d-6)alkyl,C1-4alkoxy(C1-6)alkyl, C3-6 cycloalkyl, C3-6 cycloalkyl(C1^)alkyl, phenoxy, benzyloxy, benzoyloxy, cyano, isocyano, thiocyanato, isothiocyanato, nitro, -NR""R""", :NHCOR"", -NHCONR""R"", -CONR",R,,", -S02R"", -OS02R"", -COR'", -CR'=NR"' or -N=CR"R ', in which R" and R"are independently hydrogen, C1-4alkyl, halo(CM)alkyl, C1-4alkoxy, halo(CM)alkoxy, C1-4alkylthio, C3-6 cycloalkyl, C3-6 cycloalkyl(CM)alkyl, phenyl or benzyl, the phenyl and benzyl groups being optionally substituted with halogen, C1-4alkyl or C1-4alkoxy. The invention includes a compound of the general foR""ula (1) as defined immediately above except that: C alkoxy and C1-8alkylthio are excluded as values of R and R ; C7 alkylene and C3.7 alkenylene are excluded as chains foR""ed by R and R ; the C3-6 chain that R3 and R4 may foR"" may only be optionally substituted with one or more methyl groups; thiomorpholine, thiomorpholine S-oxide, thiomorpholine S-dioxide and ^ A piperazine are excluded as rings that R and R may foR""; tri(C1-4)alkylsi1yl is excluded as a substituent of any alkyl, alkenyl, alkynyl or cycloalkyl group or moiety and any morpholine, piperidine or pyrrolidine ring is unsubstituted. The compounds of the invention may contain one or more asymmetric carbon atoms and may exist as enantiomers (or as pairs of diastereoisomers) or as mixtures of such. They may also exist as diastereoisomers by virtue of restricted rotation about a bond. However, mixtures of enantiomers or diastereoisomers may be separated into individual isomers or isomer pairs, and this invention embraces such isomers and mixtures thereof in all proportions. It is to be expected that for any given compound, one isomer may be more fungicidally active than another. Except where otherwise stated, alkyl groups and alkyl moieties of alkoxy, alkylthio, etc., contain from 1 to 8, suitably from 1 to 6 and typically from 1 to 4, carbon atoms in the foR"" of straight or branched chains. Examples are methyl, ethyl, n- and /so-propyl, N-, sec-, iso- and tert-buly1, N-pentyl and n-hexyl. Cycloalkyl groups contain from 3 to 8, typically from 3 to 6, carbon atoms and include bicycloalkyl groups such as the bicyclo[2.2.11heptyl group. Haloalkyl groups or moieties are typically trichloromethyl or trifluoromethyl or contain a trichloromethyl or trifluoromethyl teR""inal group. Except where otherwise stated, alkenyl and alkynyl moieties also contain from 2 to 8, suitably from 2 to 6 and typically from 2 to 4, carbon atoms in the foR"" of straight or branched chains. Examples are allyl, 2-methylallyl and propargyl. Optional substituents include halo, typically fluoro. An example of halo-substituted alkenyl is 3,4,4-trifluoro-n-butenyl. Halo includes fluoro, chloro, bromo and iodo. Most commonly it is fluoro, chloro or bromo and usually fluoro or chloro. Aryl is usually phenyl but also includes naphthyl, anthryl and phenanthryl. Heteroaryl is typically a 5- or 6-membered aromatic ring containing one or more O, N or S heteroatoms, which may be fused to one or more other aromatic or heteroaromatic rings, such as a benzene ring. Examples are thienyl, furyl, pyrrolyl, isoxazolyl, oxazolyl, oxadiazolyl, pyrazolyl, imidazolyl, triazolyl, isothiazolyl; tetrazolyl, thiadiazolyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, triazinyl, benzofuryl, benzothienyl, dibenzofuryl, benzothiazolyl, benzoxazolyl, benzimidazolyl, indolyl, quinolinyl and quinoxalinyl groups and, where appropriate, N-oxides thereof. The 6,6-ring systems embraced by the general foR""ula (1) are pyrido[2,3-c1pyri-dazines (where W and X are both CR8 and Y and Z are both N), pyrido[2,3-d1pyridazines (where W and Z are both CR8 and X and Y are both N), pyrido[3,2-c1pyridazines (where Y and Z are both CR8 and W and X are both N) and pyrido[2,3-b1pyrazine (where X and Y are both CR8 and W and Z are both N). Of particular interest are pyrido[2,3-b1pyrazines. R8, which may be the same or different for the two CR8 values of W, X, Y and Z, is H, halo (for example bromo), C1-4alkyl (for example methyl), C1-4alkoxy (for example methoxy) or halo(CM)alkyl (for example trifluoromethyl). Usually R8 will be H. R is halo, especially chloro or fluoro, and R2 is NR3R4. In the case of pyrido[2,3-b1pyrazine ring systems, the more active compounds are those where R is NR3R4. R3 is typically alkyl (for example ethyl, w-propyl, n-butyl, sec-butyl (the S- or R-isomer or the racemate) and terf-butyl), halo(C1-8)alkyl (for example 2,2,2-trifluoroethyl, 2,2,2-trifluoro-l-methylethyl (the S- or R-isomer or the racemate), 3,3,3-trifluoropropyl and 4,4,4-trifluorobutyl), hydroxy(C1-8)alkyl (for example hydroxyethyl), C1-4alkoxy(C1-8)alkyl (for example methoxymethyl and methoxy-zso-butyl), C1-4alkoxyhalo()alkyl (for example 2-methoxy-2-trifluromethylethyl), tri(C1-6)alkylsilyl(C1-6)alkyl (for example trimethylsilylmethyl), C1-4alkylcarbonyl(C1-8)alkyl (for example 1-acetylethyl and --tert-butylcarbonylethyl), C1-4alkylcarbonylhalo(C1-8)alkyl (for example l-acetyl-2,2,2-trifluoroethyl), phenylG-4)alkyl (for example benzyl), C2-8 alkenyl (for example allyl and methylallyl), halo(C2-8)alkenyl (for example 3-methyl-4,4-difluorobut-3-enyl), C2-8 alkynyl (for "example propargyl), C3-8 cycloalkyl (for example cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl) optionally substituted with chloro, fluoro or methyl, C3-8 cycloal-kyl(Ciuj)alkyl (for example cyclopropylmethyl, cyclobutylmethyl, cyclopentylmethyl and cyclohexylmethyl), phenylamino, piperidino or morpholino, the phenyl ring of phenylalkyl or phenylamino being optionally substituted with one, two or three substituents selected from halo (typically fluoro, chloro or bromo), C1-4alkyl (typically methyl), halo(CM)alkyl (typically trifluoromethyl), C1-4alkoxy (typically methoxy) and halo(CM)alkoxy (typically trifluoromethoxy). R4 is typically H, C1-4alkyl (for example ethyl and n-propyl), O A halo(C1-6)alkyl (for example 2,2,2-trifluoroethyl) or amino. Alternatively R and R together foR"" a C4-6 alkylene chain optionally substituted with methyl, for example 3-methylpentylene, or, together with the nitrogen atom to which they are attached, R3 and R4 foR"" a morpholine, thiomorpholine, thiomorpholine S-oxide or thiomorpholine S-dioxide ring or a piperazine or piperazine iV-(CM)alkyl (especially N-methyl) ring, in which the morpholine or piperazine rings are optionally substituted with methyl. Typically R1 is phenyl optionally substituted with from one to five halogen atoms, particularly fluorine and chlorine atoms and especially fluorine atoms or with from one to three substituents selected from halo (for example fluoro and chloro), C1-4alkyl (for example methyl), halo(C1-4)alkyl (for example trifluoromethyl), C1-4alkoxy (for example methoxy) or halo(C1-6)a example trifluoromethoxy). Examples are 2,6-difluorophenyl, 2-fluoro-6-chlorophenyl, 2,5,6-trifluorophenyl, 2,4,6-trifluorophenyl, 2,6-difluoro-4-methoxyphenyl, pentafluorophenyl, 2-fluorophenyl, 2,3,5,6-tetrafluorophenyl, 2-chloro-4,6-difluorophenyl, 2-chlorophenyl, 2,6-dichlorophenyl, 2,4-dichlorophenyl, 2,4,6-trichlorophenyl, 2,3,6-tri-chlorophenyl, pentachlorophenyl, 2-fluoro-4,6-dichlorophenyI, 4-fluoro-2,6-dichlorophenyI, 2-bromophenyl, 2-fluoro-6-bromophenyl, 2-bromo-4,6-difluorophenyl, 2-fluoro-6-methyl-phenyl, 2-chloro-6-methylphenyl, 2-methoxyphenyl, 2,6-dimethoxyphenyl, 2-fluoro-6-methoxyphenyl, 2-trifluoromethylphenyl, 2-fluoro-6-trifluoromethylphenyl, 2,6-di-(trifluoro-methyl)phenyl, 2-chloro-6-trifluoromethylphenyl, 2,4-difluoro-6-trifluoromethylphenyl, 2,4-difluoro-6-methoxyphenyl and 2,4-difluoro-6-methylphenyl. Also of particular interest are compounds where R1 is pyridyl optionally substituted with from one to four halogen atoms or with from one to three substituents selected from halo (for example fluoro and chloro), C1-4alky1 (for example methyl), halo(C1^)alkyl (for example trifluoromethyl), C1-4alkoxy (for example methoxy) or halo(C1-6)alkoxy (for example trifluoromethoxy). Examples are 2,4-difluoropyrid-3-yl, 3,5-difluoropyrid-4-yl, tetrafluoropyrid-4-yl, 3-fluoropyrid-2-yl, 4-fluoropyrid-3-yl, 3-fluoropyrid-4-yl, 2-fluoro-pyrid-3-yl, 2,4,6-trifluoropyrid-3-yl, 3,5-difluoropyrid-2-yl, 2,6-difluoropyrid-3-yl, 2,4-difluoro-6-methoxypyrid-3-yl, 2-fluorp-4-chloropyrid-3-yl, 3-fluoro-5-chloropyrid-4-yl, 2-chloro-4-fluoropyrid-3-yl, 2,4-dichloropyrid-3-yl, 3-chloropyrid-2-yl I, 4-chloropyrid-3-yl, 3-chloropyrid-4-yl, 2-chloropyrid-3-yl, 3-trifluoromethylpyrid-2-yl, 4-trifluoromethylpyrid-3-yl," 3,5-dichloropyrid-2-yl, 4,6-dichloropyrid-3-yl, 3-trifluoromethylpyrid-4-yl, 2-trifluoro-methylpyrid-3-yl, 2-fluoro-4-trifluoromethylpyrid-3-yl, 3-fluoro-5-trifluoromethylpyrid-4-yl, 4-fluoro-2-trifluoromethylpyrid-3-yl, 2,6-dichloropyrid-3-yl, 3,5-dichloropyrid-4-yl, 3-chloro-6-trrfluoromethylpyrid-2-yl, 3-fluoro-6-trifluoromethylpyrid-2-yl, pyrid-2-yl, pyrid-3-yl and pyrid-4-yl. Also of particular interest are compounds where R1 is 2- or 3-thienyl optionally substituted with from one to three halogen atoms or with from one to three substituents selected from halo (for example fluoro and chloro), C1-4alkyl (for example methyl), halo-(C1-4)alkyl (for example trifluoromethyl), C1-4alkoxy (for example methoxy) or halo(C1-4)alkoxy (for example trifluoromethoxy). Examples are 3-fluorothien-2-yl, 3-chlorothien-2-yl, 2,4-difluorothien-3-yl, 2,4-dichlorothien-3-yl and 2,4,5-tri-chlorothien-3-yl. Examples of other values of R1 of especial interest are unsubstituted piperidino and morpholino, 2-methylpiperidino, 2,6-dimethylpiperidino and 2,6-dimethylmorpholino. In one aspect the invention provides a compound of the general foR""ula (1) wherein W and X, W and Z, X and Y or Y and Z are N and the other two are CR8; R8 is H, halo, C1-4alkyl, C1-4alkoxy or halo(C1-4)alkyl; R is halo; any of the foregoing morpholine, thiomorpholine, piperidine, piperazine and pyrrolidine rings being optionally substituted with C1-4alkyl (especially methyl), and any of the foregoing aryl, heteroaryl, aryloxy or heteroaryl groups being optionally substituted with one or more substituents selected from halo, hydroxy, mercapto, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C2-6 alkenyloxy, C2-6 alkynyloxy, halo()alkyl, halo()alkoxy, C1-6alkylthio, halo(C1-6)alkylthic, hydroxy(C1-6)alkyl, C1-6alkoxy(C1-6)alkyl, C3-6 cycloalkyl, C3-6 cycloalkyl(C1-4)alkyl, phenoxy, benzyloxy, benzoyloxy, cyano, isocyano, thiocyanato, isothiocyanato, nitro, -NR""R"", -NHCOR'", -NHCONR""R"", -CONR"""R"",-S02R",-OS02R,H, -COR'", -CR"=NR,m or -N=CR"R"",in . which R" and R"" are independently hydrogen, C1-4alky1, halo(C1-4)alkyl, C1-4alkoxy, halo-(C1-4)alkoxy, C1-4alkylthio, C3-6 cycloalkyl, C3-6 cycloalkyl(C1-4)alkyl, phenyl or benzyl, the phenyl and benzyl groups being optionally substituted with halogen, C1-4alkyl or C1-4alkoxy. Of particular interest are compounds where W and Z are both N and X and Y are both CH. The invention includes a compound of the general foR""ula (1) as defined immediately above except that: C7 alkylene and C3.7 alkenylene are excluded as chains 1 A ^ A foR""ed by R and R ; the C3-6 chain that R and R may foR"" may only be optionally substituted with one or more methyl groups; thiomorpholine, thiomorpholine S-oxide, thiomorpholine S-dioxide and piperazine are excluded as rings that R and R may foR""; tri(C1-4)alkylsilyl is excluded as a substituent of any alkyl, alkenyl, alkynyl or cycloalkyl group or moiety, and any morpholine, piperidine or pyrrolidine ring is unsubstituted. In another aspect the invention provides a compound of the general foR""ula (1) piperazine N-(C1-6)a-ky,(especially TV-methyl) ring; any of the foregoing alkyl, alkenyl, alkynyl or cycloalkyl groups or moieties (other than for R8) being optionally substituted with halogen, cyano, alkoxy, C1-6alkylcarbonyl, C1-6alkoxycarbonyl, haloalkoxy, C1-6alkylthio, trKCuJalkylsilyl, C1-6 alkylamino or C-4 dialkylamino, being optionally substituted with halogen, C1-4alkyl or C1-4alkoxy. Of particular interest are compounds where W and Z are both N and X and Y are both CH. The invention includes a compound of the general foR""ula (1) as defined immediately above except that: the C4-6 chain that R and R may foR"" may only be optionally substituted with methyl; thiomorpholine, thiomorpholine S-oxide, thiomorpholine S-dioxide and piperazine are excluded as rings that R3 and R4 may foR""; tri(C1.4)alkylsilyl is excluded as a substituent of any alkyl, alkenyl, alkynyl or cycloalkyl group or moiety, and any morpholine, piperidine or pyrrolidine ring is unsubstituted. that not both R3 and R4 are H or NR5R6, or R3 and R4 together foR"" a C3.7 alkylene or C3.7 alkenylene chain optionally substituted with one or more C1-4alkyl or C1-4alkoxy groups, or, Q A together with the nitrogen atom to which they are attached, R and R foR"" a morpholine, thiomorpholine, thiomorpholine S-oxide or thiomorpholine S-dioxide ring or a piperazine or piperazine N-(C1-4)alkyl (especially N-methyl) ring; and R5 and R6 are independently H, C1-8alkyl, C2-8 alkenyl, C2-8 alkynyl, aryl, aryl(Ci-8)alkyl, C3_8cycloalkyl, C3-8cycloalkyl()alkyl, heteroaryl or heteroaryl(C1-8)alkyl; any of the foregoing alkyl, alkenyl, alkynyl or cycloalkyl groups or moieties (other than for R ) being optionally.substituted with halogen, cyano, C-C3-6alkoxy, C1-6 alkylcarbonyl, C1-6alkoxycarbonyl, C1-6 haloalkoxy, C1-6 alkylthio, tri(C1-4)alkylsilyl, C1-6 alkylamino or C1-6 dialkylamino, any of the foregoing morpholine, thiomorpholine, piperidine, piperazine and pyrrolidine rings being optionally substituted with C1-4alkyl (especially methyl), and any of the foregoing aryl or heteroaryl groups or moieties, including the phenyl group of R1, being optionally substituted with one or more substituents selected from halo, hydroxy, mercapto, C).e alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C2-6 alkenyloxy, C2-6 alkynyloxy, halo(C1-6)alkyl, halo(C1-6)alkoxy, C-4 alkylthio, halo(C1-6)alkylthio, hydroxy(C1-6)alkyl, C1-4alkoxy()alkyl, C3-6 cycloalkyl, C3_6 cycloalkyl(C1-4)alkyl, phenoxy, benzyloxy, benzoyloxy, cyano, isocyano, thiocyanato, isothiocyanato, nitro, -NR'"R""M, -NHCOR'", -NHCONR"R'"", -CONR"",R"", -S02R",-OS02R""", -COR"", -CR"=NR'm or -N=CR"",R"", in which R"" and R,,M are independently hydrogen, C1-4alkyl, halo(C1-4)alkyl, C1-4alkoxy, halo(Ci_4)alkoxy, C1-4alkylthio, C3-6 cycloalkyl, C3-6 cycloalkyl(C1-4)alkyl, phenyl or benzyl, the phenyl and benzyl groups being optionally substituted with halogen, C1-4alky' or C1-4alkoxy. Of particular interest are compounds where W and Z are both N and X and Y are both CH. The invention includes a compound of the general foR""ula (1) as defined immediately above except that: C1-8 alkoxy and C1-8 alkylthio are excluded as values of R and R ; C7 alkylene and C3.7 alkenylene are excluded as chains foR""ed by R and R ; the C3-6 chain that R3 and R4 may foR"" may only be optionally substituted with one or more methyl groups; thiomorpholine, thiomorpholine S-oxide, thiomorpholine S-dioxide and piperazine are excluded as rings that R3 and R4 may foR""; tri(C1-4)alkylsilyl is excluded as a substituent of any alkyl, alkenyl, alkynyl or cycloalky1 group or moiety, and the morpholine ring that R3 and R4 may foR"" is unsubstituted. In still yet another aspect the invention provides a compound of the general foR""ula (1) wherein W and X, W and Z, X and Y or Y and Z are N and the other two are CR8; R8 is H, halo(e.g. fluoro, chloro or bromo), C1-4alkyl (e.g. methyl), C1-4alkoxy (e.g. methoxy) or halo(C1-4)alkyl (e.g. trifluoromethyl); R is halo (e.g. fluoro, chloro or bromo); R1 is phenyl optionally substituted with from one to five halogen atoms or with from one to three substituents selected from halo, C1-4alkyl, halo(C1-4)alkyl, C1-4alkoxy or halo(C1-4) alkoxy, pyridyl optionally substituted with from one to four halogen atoms or with from one to three substituents selected from halo, C1-4alkyl, halo(C1-4)alkyl, C1-4alkoxy or halo(C1-4)alkoxy, 2- or 3-thienyl optionally substituted with from one to three halogen atoms or with from one to three substituents selected from halo, C1-4alkyl, halo(C1-4)alkyl, C1-4alkoxy or halo(C1-4)alkoxy, or piperidino or morpholino both optionally substituted with one or two methyl groups; R2 is NR3R4; R3 is C1-8 alkyl, halo(Cj-8)alkyl, hydroxy(C1-8)alkyl, C1-4alkoxy(C1-8)alkyl, C1-4alkoxyhalo-(C1-8)alkyl, tri(C1-4)alkylsilyl(C1-6)alkyl, C1-4alkylcarbonyl(C1-8)alkyl, C1-4alkylcarbonyl-halo(C1-8)alkyl, phenyl(M)alkyl, C2-8 alkenyl, halo(C2-8)alkenyl, C2-8 alkynyl, C3-8 cycloalkyl optionally substituted with chloro, fluoro or methyl,C3-8 cycloalkyl(C1-4)alkyl, phenylamino, piperidino or morpholino, the phenyl ring of phenylalkyl or phenylamino being optionally substituted with one, two or three substituents selected from halo, C1-4alkyl, halo(C1-4)alkyl, C1-4alkoxy and halo(C1-4)alkoxy; and R4 is H, C1-4alkyl, halo(C1-6)alkyl or amino, or R3 and R4 together foR"" a C3.7 alkylene or C3-7 alkenylene chain optionally substituted with methyl, or, "X A together with the nitrogen atom to which they are attached, R and R foR"" a morpholine, thiomorpholine, thiomorpholine S-oxide or thiomorpholine S-dioxide ring or a piperazine or piperazine N-(C1-4)alkyl (especially N-methyl) ring, in which the morpholine or piperazine rings are optionally substituted with methyl. Of particular interest are compounds where W and Z are both N and X and Y are both CH. In still yet another aspect the invention provides a compound of the general foR""ula (1) wherein W and X, W and Z, X and Y or Y and Z are N and the other two are CR8; R8 is H, halo, C1-4alkyl, C1-4alkoxy or haIo(C1-4)a1kyl; R is halo; R1 is phenyl optionally substituted with from one to five halogen atoms or with from one to three substituents selected from halo, C1-4alkyl, halo(C1-6)alkyl, C1-4alkoxy or halo(C1-4) alkoxy; R2 is NR3R4; R3 is C1-4alkyl, halo(C1-4)alkyl, C2-4 alkenyl, C3-6 cycloalkyl, C3-6 cycloalkyl(C1-4)alkyl or phenylamino in which the phenyl ring is optionally substituted with one, two or three substituents selected from halo, C1-4alkyl, halo(C1-4)alkyl, C1-4alkoxy and halo(C1-4)alkoxy; and R4 is H, C1-4alkyl or amino, or R3 and R4 together foR"" a C4-6 alkylene chain optionally substituted with methyl, or, together with the nitrogen atom to which they are attached, R3 and R foR"" a morpholine ring. Of particular interest are compounds where W and Z are both N and X and Y are both CH. Compounds that foR"" part of the invention are illustrated in Tables 1 to 127 below. Characterising data are given later in the Examples and in Table 133. In Table 1 the compounds have the general foR""ula (1 A), where W and Z are N, X 1 1 A and Y are CH, R is CI, R is 2,4,6-trifluorophenyl and R and R are as shown in the table. Table 2 Table 2 consists of 662 compounds of the general foR""ula (1 A), where W and Z are N, X and Y are CH, R is CI, R1 is 2,5,6-trifluorophenyl, and the values of R3 and R4 are as listed in Table 1. Thus, compound 1 of Table 2 is the same as compound 1 of Table 1 except that in compound 1 of Table 2, R1 is 2,5,6-trifluorophenyI. Similarly, compounds 2 to 662 of Table 2 are the same as compounds 2 to 662 of Table 1 except that in the compounds of """' Table 2, R1 is 2,5,6-trifluorophenyl. " Table 3 Table 3 consists of 662 compounds of the general foR""ula (1 A), where W and Z are N, X and Y are CH, R is CI, R1 is 2,3,4,5,6-pentafluorophenyl, and the values of R3 and R4 are as listed in Table 1. Thus, compound 1 of Table 3 is the same as compound 1 of Table 1 except that in compound 1 of Table 3, R1 is 2,3,4,5,6-pentafluorophenyl. Similarly, compounds 2 to 652 of Table 3 are the same as compounds 2 to 662 of Table 1 except that in the compounds of Table 3, R1 is 2,3,4,5,6-pentafluorophenyl Table 4 Table 4 consists of 662 compounds of the general foR""ula (1 A), where W and Z are N, X and Y are CH, R is CI, R1 is 2,6-difluoro-4-methoxyphenyl, and the values of R3 and R4 are as listed in Table 1. Thus, compound 1 of Table 4 is the same as compound 1 of Table 1 except that in compound 1 of Table 4, R1 is 2,6-difluoro-4-methoxyphenyl. Similarly, compounds 2 to 662 of Table 4 are the same as compounds 2 to 662 of Table 1 except that in the compounds of Table 4, R1 is 2,6-difluoro-4-methoxyphenyl. Table 5 Table 5 consists of 662 compounds of the general foR""ula (1A), where W and Z are N, X and Y are CH, R is C!, R1 is 2-fluoro-6-chlorophenyl, and the values of R3 and R4 are as listed in Table 1. Thus, compound 1 of Table 5 is the same as compound 1 of Table 1 except that in compound 1 of Table 5, R1 is 2-fluoro-6-chlorophenyl. Similarly, compounds 2 to 662 of Table 5 are the same as compounds 2 to 662 of Table 1 except that in the compounds of Table 5, R1 is 2-fIuoro-6-chlorophenyl. Table 11 Table 11 consists of 662 compounds of the general foR""ula (1 A), where W and X are N and Y and Z are CH, R is CI, R1 is 2,4,6-trifluorophenyl, and the values of R3 and R4 are as listed in Table 1. Thus, compound 1 of Table 11 is the same as compound 1 of Table 1 except that in compound 1 of Table 11, the compound has the general foR""ula (1 A) where W and X are N and Y and Z are CH. Similarly, compounds 2 to 662 of Table 11 are the same as compounds 2 to 662 of Table 1 except that in the compounds of Table 11, the compounds have the general foR""ula (1 A) where W and X are N and Y and Z are CH. Table 12 Table 12 consists of 662 compounds of the general foR""ula (1A), where W and X are N and Y and Z are CH, R is CI, R is 2,5,6-trifluorophenyl, and the values of R and R are as listed in Table 1. Thus, compound 1 of Table 12 is the same as compound 1 of Table 2 except that in compound 1 of Table 12, the compound has the general foR""ula (1 A) where W and X are N and Y and Z are CH. Similarly, compounds 2 to 662 of Table 12 are the same as compounds 2 to 662 of Table 2 except that in the compounds of Table 12, the compounds have the general foR""ula (1 A) where W and X are N and Y and Z are CH. Table 13 Table 13 consists of 662 compounds of the general foR""ula (1 AX where W and X are N and Y and Z are CH, R is CI, R1 is 2,3,4,5,6-pentafluorophenyl, and the values of R3 and R4 are as listed in Table 1. Thus, compound 1 of Table 13 is the same as compound 1 of Table 3 except that in compound 1 of Table 13, the compound has the general foR""ula (1 A) where W and X are N and Y and Z are CH. Similarly, compounds 2 to 662 of Table 13 are the same as compounds 2 to 662 of Table 3 except that in the compounds of Table 13, the compounds have the general foR""ula (1 A) Where W and X are N and Y and Z are CH. Table 14 Table 14 consists of 662 compounds of the general foR""ula (1 A), where W and X are N and Y and Z are CH, R is CI, R1 is 2,6-difluoro-4-methoxyphenyl, and the values of R3 and R4 are as listed in Table 1. Thus, compound 1 of Table 14 is the same as compound 1 of Table 4 except that in compound 1 of Table 14, the compound has the general foR""ula (1 A) where W and X are N and Y and Z are CH. Similarly, compounds 2 to 662 of Table 14 are the same as compounds 2 to 662 of Table 4 except that in the compounds of Table 14, the compounds have the general foR""ula (1 A) where W and X are N and Y and Z are CH. Table 15 Table 15 consists of 662 compounds of the general foR""ula (1 A), where W and X are N and Y and Z are CH, R is CI, R1 is 2-fluoro-6-chlorophenyl, and the values of R3 and R4 are as listed in Table 1. Thus, compound 1 of Table 15 is the same as compound 1 of Table 5 except that in compound 1 of Table 15, the compound has the general foR""ula (1 A) where W and X are N and Y and Z are CH. Similarly, compounds 2 to 662 of Table 15 are the same as compounds 2 to 662 of Table 5 except that in the compounds of Table 15, the compounds have the general foR""ula (1 A) where W and X are N and Y and Z are CH. Table 21 Table 21 consists of 662 compounds of the general foR""ula (1A), where W and Z are CH and X and Y are N, R is CI, R1 is 2,4,6-trifluorophenyl, and the values of R3 and R4 are as listed in Table 1. Thus, compound 1 of Table 21 is the same as compound 1 of Table 1 except that in compound 1 of Table 21, the compound has the general foR""ula (1 A) where W and Z are CH and X and Y are N. Similarly, compounds 2 to 662 of Table 21 are the same as compounds 2 to 662 of Table 1 except that in the compounds of Table 21, the compounds have the general foR""ula (1 A) where W and Z are CH and X and Y are N. Table 22 Table 22 consists of 662 compounds of the general foR""ula (1 A), where W and Z are 1 ""2 A CH and X and Y are N, R is CI, R is 2,5,6-trifluorophenyl, and the values of R and R are as listed in Table 1. Thus, compound 1 of Table 22 is the same as compound 1 of Table 2 except that in compound 1 of Table 22, the compound has the general foR""ula (1A) where W and Z are CH and X and Y are N. Similarly, compounds 2 to 662 of Table 22 are the same as compounds 2 to 662 of Table 2 except that in the compounds of Table 22, the compounds have the genera) foR""ula (1 A) where W and Z are CH and X and Y are N. Table 23 Table 23 consists of 662 compounds of the general foR""ula (1A), where W and Z are CH and X and Y are N, R is CI, R1 is 2,3,4,5,6-pentafluorophenyl, and the values of R3 and R4 are as listed in Table 1. Thus, compound 1 of Table 23 is the same as compound 1 of Table 3 except that in compound 1 of Table 23, the compound has the general foR""uia (1 A) where W and Z are CH and X and Y are N. Similarly, compounds 2 to 662 of Table 23 are the same as compounds 2 to 662 of Table 3 except that in the compounds of Table 23, the compounds have the general foR""ula (1 A) where W and Z are CH and X and Y are N. , Table 24 Table 24 consists of 662 compounds of the general foR""ula (1 A), where W and Z are CH and X and Y are N, R is CI, R1 is 2,6-difluoro-4-methoxyphenyl, and the values of R3 and R4 are as listed in Table 1. Thus, compound 1 of Table 24 is the same as compound 1 of Table 4 except that in compound 1 of Table 24, the compound has the general foR""ula (1 A) where W and Z are CH and X and Y are N. Similarly, compounds 2 to 662 of Table 24 are the same as compounds 2 to 662 of Table 4 except that in the compounds of Table 24, the compounds have the general foR""ula (1 A) where W and Z are CH and X and Y are N. Table 25 Table 25 consists of 662 compounds of the general foR""ula (1 A), where W and Z are CH and X and Y are N, R is CI, RC3-6is 2-fluoro-6-chlorophenyl, and the values of R3 and R4 are as listed in Table 1. Thus, compound 1 of Table 25 is the same as compound 1 of Table 5 except that in compound 1 of Table 25, the compound has the general foR""ula (1 A) where W and Z are CH and X and Y are N. Similarly, compounds 2 to 662 of Table 25 are the same as compounds 2 to 662 of Table 5 except that in the compounds of Table 25, the compounds have the general foR""ula (1 A) where W and Z are CH and X and Y are N. Table 26 Table 26 consists of 662 compounds of the general foR""ula (1A), where W and X are CH and Y and Z are N, R is CI, R is 2,4,6-trifluorophenyl, and the values of R and R are as listed in Table 1. Thus, compound 1 of Table 26 is the same as compound 1 of Table 1 except that in compound 1 of Table 26, the compound has the general foR""ula (1 A) where W and X are CH and Y and Z are N. Similarly, compounds 2 to 662 of Table 26 are the same as compounds 2 to 662 of Table 1 except that in the compounds of Table 26, the compounds have the general foR""ula (1 A) where W and X are CH and Y and Z are N. Table 27 Table 27 consists of 662 compounds of the general foR""ula (1A), where W and X are CH and Y and Z are N, R is CI, R1 is 2,5,6-trifluorophenyl, and the values of R3 and R4 are as listed in Table 1. Thus, compound 1 of Table 27 is the same as compound 1 of Table 2 except that in compound 1 of Table 27, the compound has the general foR""ula (1 A) where W and X are CH and Y and Z are N. Similarly, compounds 2 to 662 of Table 27 are the same as compounds 2 to 662 of Table 2 except that in the compounds of Table 27, the compounds have the general foR""ula (1 A) where W and X are CH and Y and Z are N. Table 28 Table 28 consists of 662 compounds of the general foR""ula (1 A), where W and X are CH and Y and Z are N, R is CI, R is 2,3,4,5,6-pentafluorophenyl, and the values of R and R4 are as listed in Table 1. Thus, compound 1 of Table 28 is the same as compound 1 of Table 3 except that in compound 1 of Table 28, the compound has the general foR""ula (1 A) where W and X are CH and Y and Z are N. Similarly, compounds 2 to 662 of Table 28 are the same as compounds 2 to 662 of Table 3 except that in the compounds of Table 28, the compounds have the general foR""ula (1 A) where W and X are CH and Y and Z are N. Table 29 Table 29 consists of 662 compounds of the general foR""ula (1A), where W and X are CH and Y and Z are N, R is CI, R1 is 2,6-difluoro-4-methoxyphenyl, and the values of R3 and R4 are as listed in Table 1. Thus, compound 1 of Table 29 is the same as compound 1 of Table 4 except that in compound 1 of Table 29, the compound has the general foR""ula (1 A) where W and X are CH and Y and Z are N. Similarly, compounds 2 to 662 of Table 29 are the same as compounds 2 to 662 of Table 4 except that in the compounds of Table 29, the compounds have the general foR""ula (1 A) where W and X are CH and Y and Z are N. Table 30 Table 30 consists of 662 compounds of the general foR""ula (1 A), where W and X are CH and Y and Z are N, R is CI, R! is 2-fluoro-6-chlorophenyl, and the values of R3 and R4 are as listed in Table 1. Thus, compound 1 of Table 30 is the same as compound 1 of Table 5 except that in compound 1 of Table 30, the compound has the general foR""ula (1 A) where W and X are CH and Y and Z are N. Similarly, compounds 2 to 662 of Table 30 are the same as compounds 2 to 662 of Table 5 except that in the compounds of Table 30, the compounds have the genera1 foR""ula (1 A) where W and X are CH and Y and Z are N. Table 31 Table 31 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 31 R1 is 2,6-difluorophenyl instead of 2-fluoro-6-chlorophenyl. Table 32 Table 32 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 32 R1 is 2-fluorophenyl instead of 2-fluoro-6-chlorophenyl. Table 33 Table 33 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 33 R1 is 2,3,5,6-tetrafluorophenyl instead of 2-fluoro-6-chlorophenyl. Table 34 Table 34 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 34 R1 is 2-chloro-4,6-difluorophenyl instead of 2-fluoro-6-chloro-phenyl. Table 35 Table 35 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 35 R1 is 2-chlorophenyl instead of 2-fluoro-6-chlorophenyl. Table 36 Table 36 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of.Table 36 R1 is 2,6-dichlorophenyl instead of 2-fluoro-6-chlorophenyl. Table 37 Table 37 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 37 R1 is 2,4-dichlorophenyl instead of 2-fluoro-6-chlorophenyl. Table 38 Table 38 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 38 R1 is 2,4,6-trichlorophenyl instead of 2-fluoro-6-chlorophenyl. Table 39 Table 39 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 39 R1 is 2,3,6-trichlorophenyl instead of 2-fluoro-6-chlorophenyl. Table 40 Table 40 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 40 R1 is pentachlorophenyl instead of 2-fluoro-6-chlorophenyl. Table 41 Table 41 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 41 R1 is 2-fluoro-4,6-dichlorophenyl instead of 2-fluoro-6-chloro-phenyl. Table 42 Table 42 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 42 R1 is 4-fluoro-2,6-dichlorophenyl instead of 2-fluoro-6-chloro-phenyl. Table 43 Table 43 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 43 R1 is 2-bromophenyl instead of 2-fluoro-6-chIorophenyI. Table 44 Table 44 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are'exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 44 R1 is 2-fluoro-6-bromophenyl instead of 2-fluoro-6-chlorophenyl. Table 45 Table 45 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 45 R1 is 2-bromo-4,6-difluorophenyl instead of 2-fluoro-6-chloro-phenyl. Table 46 Table 46 consists of 2648 compounds. Compounds 1 to 662 are_ exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 46 R1 is 2-fluoro-6-methylphenyl instead of 2-fIuoro-6-chlorophenyl. Table 47 Table 47 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the - compounds of Table 47 R1 is 2-chloro-6-methylphenyl instead of 2-fluoro-6-chlorophenyl. Table 48 Table 48 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 48 R1 is 2-methoxyphenyl instead of 2-fluoro-6-chlorophenyl. Table 49 Table 49 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 49 R1 is 2,6-dimethoxyphenyl instead of 2-fluoro-6-chlorophenyl. Table 50 Table 50 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table. 5j""espectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 50 R1 is 2-fluoro-6-methoxyphenyl instead of 2-fluoro-6-chlorophenyl. Table 51 Table 51 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 51 R1 is 2-trifluoromethylphenyl instead of 2-fluoro-6-chlorophenyl. Table 52 Table 52 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively^except that in all of the compounds of Table 52 R1 is 2-fluoro-6-trifluoromethylphenyl instead of 2-fluoro-6-chloro-phenyl. Table 53 Table 53 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 53 R1 is 2,6-di-(trifluoromethyl)phenyl instead of 2-fluoro-6-chloro-phenyl. Table 54 Table 54 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of tHe compounds of Table 54 R1 is 2-chloro-6-trifluoromethylphenyl instead of 2-fluoro-6-chlorophenyl. Table 55 Table 55 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 55 R1 is 2,4-difluoro-6-trifluoromethylphenyl instead of 2-fluoro-6-chlorophenyl. Table 56 Table 56 consists of 2648 compounds, Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively," compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 56 R1 is 2,4-difluoro-6-methoxyphenyl instead of 2-fluoro-6-chloro-phenyl. Table 57 Table 57 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are C3-6exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 57 R1 is 2,4-difluoro-6-methy1phenyl instead of 2-fluoro-6-chloro-phenyl. Table 58 Table 58 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 58 R1 is 2,4-difIuoropyrid-3-yl instead of 2-fluoro-6-chlorophenyl. Table 59 Table 59 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 59 R1 is 3,5-difluoropyrid-4-yl instead of 2-fluoro-6-chlorophenyl. Table 60 Table 60 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 60 R1 is tetrafluoropyrid-4-yl instead of 2-fluoro-6-chlorophenyl. Table 61 Table 61 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 61 R1 is 3-fluoropyrid-2-yl instead of 2-fluoro-6-chlorophenyl. Table 62 Table 62 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 62 R1 is 4-fluoropyrid-3-yl instead of 2-fluoro-6-chlorophenyl. Table 63 Table 63 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 63 R1 is 3-fluoropyrid-4-yl instead of 2-fluoro-6-chlorophenyl. Table 64 Table 64 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 64 R1 is 2-fluoropyrid-3-yl instead of 2-fluoro-6-chlorophenyl. Table 65 Table 65 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 65 R1 is 2,4,6-trifluoropyrid-3-yl instead of 2-fluoro-6-chlorophenyl. Table 66 Table 66 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 66 R1 is 3,5-difluoropyrid-2-yl instead of 2-fluoro-6-chlorophenyl. Table 67 Table 67 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 67 R1 is 2,6-difluoropyrid-3-yl instead of 2-fluoro-6-chlorophenyl. Table 68 Table 68 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 68 R is 2,4-difluoro-6-methoxypyrid-3-yl instead of 2-fluoro-6-chloro-phenyl. Table 69 Table 69 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 69 R1 is 2-fluoro-4-chloropyrid-3-yl instead of 2-fluoro-6-chlorophenyl. " Table 70 Table 70 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 70 R1 is 3-fluoro-5-chloropyrid-4-yl instead of 2-fluoro-6-chlorophenyl. Table 71 Table 71 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 71 R1 is 2-chloro-4-fluoropyrid-3-yl instead of 2-fluon>6-chlorophenyl. Table 72 Table 72 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 72 R1 is 2,4-dichloropyrid-3-yl instead of 2-fluoro-6-chlorophenyl. Table 73 Table 73 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 73 R1 is 3-chloropyrid-2-yl instead of 2-fluoro-6-chlorophenyl. Table 74 Table 74 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662%of Table 30 respectively, except that in all of the compounds of Table 74 R1 is 4-chloropyrid-3-yl instead of 2-fluoro-6-chlorophenyl. Table 75 Table 75 .consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 75 R1 is 3-chloropyrid-4-yl instead of 2-fluoro-6-chlorophenyl. Table 76 Table 76 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 76 R is 2-chloropyrid-3-yl instead of 2-fluoro-6-chlorophenyl. Table 77 Table 77 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 77 R! is 3-trifluoromethylpyrid-2-yl instead of 2-fluoro-6-chlorophenyl. Table 78 Table 78 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 78 R1 is 4-trifluoromethylpyrid-3-yl instead of 2-fluoro-6-chlorophenyl. Table 79 Table 79 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 79 R1 is 3,5-dichloropyrid-2-yl instead of 2-fluoro-6-chlorophenyl. Table 80 Table 80 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 80 R1 is 4,6-dichloropyrid-3-yl instead of 2-fluoro-6-chlorophenyl. Table 81 Table 81 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of tHe compounds of Table 81 R1 is 3-trifluoromethylpyrid-4-yl instead of 2-fluoro-6-chlorophenyl. Table 82 Table 82 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 82 R1 is 2-trifluoromethylpyrid-3-yl instead of 2-fluoro-6-chlorophenyl. Table 83 Table 83 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 83 R1 is 2-fluoro-4-trifluorornethylpyrid-3-yl instead of 2-fluoro-6-chlorophenyl. Table 84 Table 84 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 84 R1 is 3-fluoro-5-trifluoromethylpyrid-4-yl instead of 2-fluoro-6-chlorophenyl. Table 85 Table 85 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 85 R1 is 4-fluoro-2-trifluoromethylpyrid-3-yl instead of 2-fluoro-6- chlorophenyl. Table 86 Table 86 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 86 R1 is 2,6-dichloropyrid-3-yl instead of 2-fluoro-6-chlorophenyl. Table 87 Table 87 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 87 R1 is 3,5-dichloropyrid-4-yl instead of 2-fluoro-6-chlorophenyl. Table 88 Table 88 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 88 R1 is 3-chloro-6-trifluoromethylpyrid-2-yl instead of 2-fluoro-6-chlorophenyl. Table 89 Table 89 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 89 R1 is 3-fluoro-6-trifluoromethylpyrid-2-yl instead of 2-fluoro-6-chlorophenyl. Table 90 Table 90 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 90 R1 is pyrid-2-yl instead of 2-fluoro-6-chlorophenyl. Table 91 Table 91 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 91 R1 is pyrid-3-yl instead of 2-fluoro-6-chlorophenyl. - C3-6- Table 92 Table 92 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 92 R1 is pyrid-4-yl instead of 2-fluoro-6-chlorophenyl. Table 93 Table 93 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 93 R1 is 3-fluorothien-2-yl instead of 2-fluoro-6-chlorophenyl. Table 94 Table 94 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 io 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 94 R1 is 3-chlorothien-2-yl instead of 2-fIuoro-6-chlorophenyl. Table 95 Table 95 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 95 R1 is 2,4-difluorothien-3-yl instead of 2-fluoro-6-chlorophenyl. Table 96 Table 96 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 96 R1 is 2,4-dichlorothien-3-yl instead of 2-fluoro-6-chlorophenyl. Table 97 Table 97 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table R1 is 2,4,5-trichlorothien-3-yl instead of 2-fluoro-6-chlorophenyl. Table 98 Table 98 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 98 R1 is piperidino instead of 2-fluoro-6-chlorophenyl. Table 99 Table 99 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1-to 662 of Table 30 respectively, except that in all of the compounds of Table 99 R1 is 2-methylpiperidino instead of 2-fluoro-6-chlorophenyl. Table 100 Table 100 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 100 R1 is 2,6-dimethylpiperidino instead of 2-fluoro-6-chlorophenyl. Table 101 Table 101 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 101 R1 is morpholino instead of 2-fluoro-6-chlorophenyl. Table 102 Table 102 consists of 2648 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectively, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectively, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectively, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectively, except that in all of the compounds of Table 102 R1 is 2,6-dimethylmorpholino instead of 2-fluoro-6-chlorophenyl. Table 103 Table 103 consists of 201,248 compounds. Each of these compounds is exactly the same as the corresponding compound in Tables 1 to 102 (thus, for example, compound 1 of Table 103 is the same as compound 1 of Table 1, compound 663 of Table 103 is the same as compound 1 of Table 2, compound 19,861 of Table 103 is the same as compound 1 of Table 31, compound 305,844 of Table 103 is the same as compound 3,972 of Table 102) except that in all of the compounds of Table 103 R is F instead of CI. Table 104 Table 104 consists of 201,248 compounds. Each of these compounds is exactly the same as the corresponding compound in Tables 1 to 102 (thus, for example, compound 1 "of Table 104 is the same as compound 1 of Table 1, compound 663 of Table 104 is the same as compound 1 of Table 2, compound 19,861 of Table 104 is the same as compound 1 of Table 31, compound 305,844 of Table 104 is the same as compound 3,972 of Table 102) except that in all of the compounds of Table 104 R is Br instead of CI. Table 109 Table 109 consists of 3310 compounds. Each of these compounds is exactly the same as the corresponding compound in Tables 1 to 5 (thus, for example, compound 1 of Table 109 is the same as compound 1 of Table 1, compound 663 of Table 109 is the same as compound 1 of Table 2, etc.) except that in all of the compounds of Table 109 X is CF instead of CH. Table 110 Table 110 consists of 3310c compounds. Each of these compounds is exactly the same as the corresponding compound in Tables 1 to 5 (thus, for example, compound 1 of Table 110 is the same as compound 1 of Table 1, compound 663 of Table 110 is the same as compound 1 of Table 2, etc.) except that in all of the compounds of Table 110 X is CC1 instead of CH. Table 111 Table 111 consists of 3310 compounds. Each of these compounds is exactly the same as the corresponding compound in Tables 1 to 5 (thus, for example, compound 1 of Table 111 is the same as compound 1 of Table 1, compound 663 of Table 111 is the same as compound 1 of Table 2, etc.) except that in all of the compounds of Table 111 X is CBr instead of CH. Table 112 Table 112 consists of 3310 compounds. Each of these compounds is exactly the same as the corresponding compound in Tables 1 to 5 (thus, for example, compound 1 of Table 112 is the same as compound 1 of Table 1, compound 663 of Table 112 is the same as compound 1 of Table 2, etc.) except that in all of the compounds of Table 112 X is CCH3 instead of CH. Table 113 Table 113 consists of 3310 compounds. Each of these compounds is exactly the same as the corresponding compound in Tables 1 to 5 (thus, for example, compound 1 of Table 113 is the same as compound 1 of Table 1, compound 663 of Table 113 is the same as compound 1 of Table 2, etc.) except that in all of the compounds of Table 113 Y is CF instead of CH. Table 114 Table 114 consists of 3310 compounds. Each of these compounds is exactly the same as the corresponding compound in Tables 1 to 5 (thus, for example, compound 1 of Table 114 is the same as compound 1 of Table 1, compound 663 of Table 114 is the same as compound 1 of Table 2, etc.) except that in all of the compounds of Table 114 Y is CC1 instead of CH. Table 115 Table 115 consists of 3310 compounds. Each of these compounds is exactly the same as the corresponding compound in Tables 1 to 5 (thus, for example, compound 1 of Table 115 is the same as compound 1 of Table 1, compound 663 of Table 115 is the same as compound 1 of Table 2, etc.) except that in all of the compounds of Table 115 Y is CBr instead of CH. Table 116 Table 116 consists of 3310 compounds. Each of these compounds is exactly the same as the corresponding compound in Tables 1 to 5 (thus, for example, compound 1 of Table 116 is the same as compound 1 of Table 1, compound 663 of Table 116 is the same as compound 1 of Table 2, etc.) except that in all of the compounds of Table 116 Y is CCH3 instead of CH. Compounds of foR""ula (7) or (8), which are examples of compounds of general foR""ula (1) where one of R and R is NR R , can be made as shown in Scheme 1, in which W, X, Y, Z, R1, R3 and R4 have the meanings given above and R7 is C1-4alkyl. Compounds of general foR""ula (4) can be prepared from compounds of general foR""ula (2), which are either commercially available or made by methods known in the literature, by reaction with acids of general foR""ula β), using standard coupling methods, for example by conversion to the acid chloride using a chlorinating agent such as thionyl chloride, followed by reaction of the resultant acid chloride optionally in the presence of a base such as triethylamine, in a suitable solvent such as dichloromethane or toluene. Compounds of general foR""ula (5) can be prepared by treating compounds of general foR""ula (4) with a base such as sodium hydride, optionally in the presence of a Lewis acid such as magnesium oxide, in a suitable solvent such as N, N-dimethylfoR""amide (DMF) or toluene, at between room temperature and 150°C, but preferably at 60-90°C. Compounds of general foR""ula (6) can be prepared by reaction of compounds of general foR""ula (5) with a chlorination reagent such as phosphorus oxychloride, either neat or in a suitable solvent such as toluene, at between 50 and 150°C, but preferably between 80 and 110°C, or in a microwave reactor at between 150 and 300°C, but preferably between 200 and 250°C Compounds of foR""ula (7) and (8) can be prepared by reaction of compounds of general 1 A foR""ula (6) with an amine R R NH, either neat, or in a suitable solvent such as DMF, between room temperature and 150°C, but preferably between 50 and 80°C. If compounds (7) and (8) are produced as a mixture they can be separated by suitable means such as crystallisation or chromatography under noR""al or reverse phase conditions. Compounds of the general foR""ulae (5), (6), (7) and (8) may be derivatised, via the chloro or hydroxy substituents, using routine chemical techniques to foR"" other compounds of the general foR""ula (1). Alternatively, other compounds of the general foR""ula (1) may be prepared using a similar methodology to that described for preparing the compounds (5) to (8) and employing preparative techniques known from the chemical literature. Compounds of foR""ula (7) can also be made as shown in Scheme 2. Compounds of general foR""ula (10) can be prepared from compounds of general foR""ula (9), which are either commercially available or made by methods known in the literature, by reaction with acids of general foR""ula β), using standard coupling methods, for example by conversion to the acid chloride using a chlorinating agent such as thionyl chloride, followed by reaction of the resultant acid chloride optionally in the presence of a base such as triethylamine, in a suitable solvent such as dichloromethane or toluene. Compounds of general foR""ula (11) can be prepared by treating compounds of general foR""ula (10) with a base such as sodium hydride, optionally in the presence of a Lewis acid such as magnesium oxide, in a suitable solvent such as Af,N-dimethylfoR""amide (DMF) or toluene, at between room temperature and 150°C, but preferably at 60-90°C. Compounds of genera1 foR""ula (12) can be prepared by reaction of compounds of general foR""ula (11) with a chlorination reagent such as phosphorus oxychloride, either neat or in a suitable solvent such as toluene, at between 50 and 150°C, but preferably between 80 and 110°C, or in a microwave reactor at between 150 and 300°C, but preferably between 200 and 250°C. Compounds of foR""ula (7) can be prepared from compounds of foR""ula (12) by reductive amination, for example by reaction with a ketone or aldehyde in a suitable solvent such as ethanol or toluene, at between room temperature and reflux, optionally in the presence of an acid catalyst such as para-toluenesulphonic acid or a drying agent such as molecular sieves, followed by treatment with a suitable reducing agent such as sodium borohydride, at between -20°C and 40°C, but preferably at room temperature. The aldehyde or ketone is chosen so that the desired groups R3 and R4 are foR""ed after reduction of the product of reaction with the amine (12). For example if compounds of foR""ula (12) are reacted with one equivalent of propionaldehyde and then sodium borohydride, compounds of foR""ula (7) where R is n-propyl, and R4 is hydrogen are foR""ed. If required, the reaction can be repeated with a different aldehyde or ketone. For example, if acetone is used for the second reaction, then compounds of foR""ula (7) where R is n-propyl and R is iso-propyl, are foR""ed. Alternatively compounds of foR""ula (7) can be foR""ed from compounds of foR""ula (12) by alkylation with a group R3LG, by treatment with a suitable base such as sodium hydride in a solvent such as DMF, or a base such as potassium carbonate in a solvent such as acetone or DMF, at between -78°C and 100°C, but preferably between room temperature and 60°C, followed by treatment with R4LG in a second step under the same conditions if required. Compounds of foR""ula (13) can be prepared as shown in Scheme 3 from compounds of foR""ula (6) by reaction with a source of fluoride ion, such as potassium fluoride, in a suitable solvent such as sulphol^ne, at a temperature between ""50°C and 200°C, but preferably at 80-150°C Compounds of foR""ula (14) and/or compounds of foR""ula (15) can be prepared from difluoro compounds of foR""ula (13) by reaction with an amine of foR""ula R R NH in a suitable solvent such as DMF or CH2CI2, at a temperature of 0°C-100°C, but preferably at room temperature. The invention as defined by the genera1 foR""ula (5) embraces all such tautomers. Of particular interest are the inteR""ediates listed in Tables 128 to 132 below. In Table 128 the compounds have the general foR""ula (4) where R7 is methyl and W, X, Y, Z and R1 have the values shown in the table. Table 129 Table 129 consists of 48 compounds of the general foR""ula (5), where W, X, Y, Z and R1 have the values given in Table 128. Thus, compound 1 of Table 129 has the same W, X, Y, Z and R1 values as compound 1 of Table 128, etc. Table 130 Table 130 consists of 48 compounds of the general foR""ula (6), where W, X, Y, Z and R1 have the values given in Table 128. Thus, compound 1 of Table 130 has the same W, X, Y, Z and R1 values as compound 1 of Table 128, etc. Table 131 Table 131 consists of 48 compounds of the general foR""ula (13), where W, X, Y, Z and R1 have the values given in Table 128. Thus, compound 1 of Table 131 has the same W, X, Y, Z and R1 values as compound 1 of Table 128, etc. Table 132 Table 132 consists of 48 compounds of the general foR""ula (4), where W, X, Y, Z and R1 have the values given in Table 128 and R7 is ethyl. Thus, compound 1 of Table 132 is the same as compound 1 of Table 128 except that in compound 1 of Table 132, R7 is ethyl instead of methyl. Similarly, compounds 2 to 48 of Table 132 are the same as compounds 2 to 48 of Table 128 except that in the compounds of Table 132, R7 is ethyl. The compounds of foR""ula (1) are active fungicides and may be used to control one or more of the following pathogens: Pyricularia oryzae {Magnaporthe grisea) on rice and wheat and other Pyricularia spp. on other hosts; Puccinia triticina (or recondita), Puccinia striifoR""is and other rusts on wheat, Puccinia hordei, Puccinia striifoR""is and other rusts on barley, and rusts on other hosts (for example turf, rye, coffee, pears, apples, peanuts, sugar beet, vegetables and ornamental plants); Erysiphe cichoracearum on cucurbits (for example melon); Blumeria (or Erysiphe) graminis (powdery mildew) on barley, wheat, rye and turf and other powdery mildews on various hosts, such as Sphaerotheca macularis on hops, Sphaerotheca fusca (Sphaerotheca fuliginea) on cucurbits (for example cucumber), Leveillula taurica on tomatoes, aubergine and green pepper, Podosphaera leucotricha on apples and Uncimda necator on vines; Cochliobolus spp., Helminthosporiwn spp., Drechslera spp. (Pyrenophora spp.), Rhynchosporium spp., Mycosphaerella graminicola (Septoria tritici) and Phaeosphaeria nodorum (Stagonospora nodorum or Septoria nodorum), Pseudocercosporella herpotrichoides and Gaeumannomyces graminis on cereals (for example wheat, barley, rye), turf and other hosts; Cercospora arachidicola and Cercosporidium personatum on peanuts and other Cercospora spp. on other hosts, for example sugar beet, bananas, soya beans and rice; Botrytis cinerea (grey mould) on tomatoes, strawberries, vegetables, vines and other hosts and other Botrytis spp. on other hosts; Alternaria spp. on vegetables (for example carrots), oil-seed rape, apples, tomatoes, potatoes, cereals (for example wheat) and other hosts; Venturia spp. (including Venturia inaequalis (scab)) on apples, pears, stone fruit, tree nuts and other hosts; Cladosporium spp. on a range of hosts including cereals (for example wheat) and tomatoes; Monilinia spp. on stone fruit, tree nuts and other hosts; Didymella spp. on tomatoes, turf, wheat, cucurbits and other hosts; Phoma spp. on oil-seed rape, turf, rice, potatoes, wheat and other hosts; Aspergillus spp. and Aureobasidium spp. on wheat, lumber and other hosts; Ascochyta spp. on peas, wheat, barley and other hosts; Stemphylium spp. (Pleospora spp.) on apples, pears, onions and other hosts; summer diseases (for example bitter rot (Glomerella cingulata), black rot or frogeye leaf spot (Botryosphaeria obtusa), Brooks fruit spot (Mycosphaerella pomi), Cedar apple rust (Gymnosporangiumjuniperi-virginianae), sooty blotch (Gloeodes pomigena), flyspeck (Schizothyrium pomi) and white rot (Botryosphaeria dothidea)) on apples and pears; Plasmopara viticola on vines; other downy mildews, such as Bremia lactucae on lettuce, Peronospora spp. on soybeans, tobacco, onions and other hosts, Pseudoperonospora humiili on hops and Pseudoperonospora cubensis on cucurbits; Pythium spp. (including Pythium ultimum) on turf and other hosts; Phytophthora infestans on potatoes and tomatoes and other Phytophthora spp. on vegetables, strawberries, avocado, pepper, ornamentals, tobacco, cocoa and other hosts; Thanatephorus cucumeris on rice and turf and other Rhizoctonia spp. on various hosts such as wheat and barley, peanuts, vegetables, cotton and turf; Sclerotinia spp. on turf, peanuts, potatoes, oil-seed rape and other hosts; Sclerotium spp. on turf, peanuts and other hosts; Gibberella fujikuroi on rice; Colletotrichum spp. on a range of hosts including turf, coffee and vegetables; Laetisaria fucifoR""is on turf; Mycosphaerella spp. on bananas, peanuts, citrus, pecans, papaya and other hosts; Diaporthe spp. on citrus, soybean, melon, pears, lupin and other hosts; Elsinoe spp. on citrus, vines, olives, pecans, roses and other hosts; Verticillium spp. on a range of hosts including hops, potatoes and tomatoes; Pyrenopeziza spp. on oil-seed rape and other hosts; Oncobasidium theobromae on cocoa causing vascular streak dieback; Fusarium spp., Typhitla spp., Microdochium nivale, Ustilago spp., Urocystis spp., Tilletia spp. and Claviceps purpurea on a variety of hosts but particularly wheat, barley, turf and maize; Ramularia spp. on sugar beet, barley and other hosts; post-harvest diseases particularly of fruit (for example Penicillium digitatum, Penicillium italicum and TrichodeR""a viride on oranges, Colletotrichum musae and Gloeosporium musarum on bananas and Botrytis cinerea on grapes); other pathogens on vines,-notably Eutypa lata, Guignardia bidwellii, Phellinus igniarus, Phomopsis viticola, Pseudopeziza tracheiphila and Stereum hirsutum; other pathogens on trees (for example LophodeR""ium seditiosum) or lumber, notably Cephaloascus fragrans, Ceratocystis spp., Ophiostoma piceae, Penicillium spp., TrichodeR""a pseudokoningii, TrichodeR""a viride, TrichodeR""a harzianum, Aspergillus niger, Leptographium lindbergi and Aureobasidium pullulans; and fungal vectors of viral diseases (for example Polymyxa graminis on cereals as the vector of barley yellow mosaic virus (BYMV) and Polymyxa betae on sugar beet as the vector of rhizomania). A compound of foR""ula (1) may move acropetally, basipetally or locally in plant tissue to be active against one or more fungi. Moreover, a compound of foR""ula (1) may be volatile enough to be active in the vapour phase against one or more fungi on the plant. The invention therefore provides a method of combating or controlling phytopatho-genic fungi which comprises applying a fungicidally effective amount of a compound of foR""ula (1), or a composition containing a compound of foR""ula (1), to a plant, to a seed of a plant, to the locus of the plant or seed or to soil or any other plant growth medium, e.g. nutrient solution. The teR"" "plant" as used herein includes seedlings, bushes and trees. FurtheR""ore, the fungicidal method of the invention includes protectant, curative, systemic, eradicant and antisporulant treatments. The compounds of foR""ula (1) are preferably used for agricultural, horticultural and turfgrass purposes in the foR"" of a composition. In order to apply a compound of foR""ula (1) to a plant, to a seed of a plant, to the locus of the plant or seed or to soil or any other growth medium, a compound of foR""ula (1) is usually foR""ulated into a composition which includes, in addition to the compound of foR""ula (1), a suitable inert diluent or carrier and, optionally, a surface active agent (SFA). SFAs are chemicals that are able to modify the properties of an interface (for example, liquid/solid, liquid/air or liquid/liquid interfaces) by lowering the interfacial tension and thereby leading to changes in other properties (for example dispersion, emulsification and wetting). It is preferred that all compositions (both solid and liquid foR""ulations) comprise, by weight, 0.0001 to 95%, more preferably 1 to 85%, for example 5 to 60%, of a compound of foR""ula (1). The composition is generally used for the control of fungi such that a compound of foR""ula (1) is applied at a rate of from 0.1 g to 10kg per hectare, preferably from lg to 6kg per hectare, more preferably from lg to 1kg per hectare. When used in a seed dressing, a compound of foR""ula (1) is used at a rate of O.OOOJg to lOg (for example 0.00lg or 0.05g), preferably 0.005g to lOg, more preferably 0.005g to 4g, per kilogram of seed. In another aspect the present invention provides a fungicidal composition comprising a fungicidally effective amount of a compound of foR""ula (1) and a suitable carrier or diluent therefor. In a still further aspect the invention provides a method of combating and controlling fungi at a locus, which comprises treating the fungi, or the locus of the fungi with a fungicidally effective amount of a composition comprising a compound of foR""ula (1). The compositions can be chosen from a number of foR""ulation types, including dustable powders (DP), soluble powders (SP), water soluble granules (SG), water dispersible granules (WG), wettable powders (WP), granules (GR) (slow or fast release), soluble concentrates (SL), oil miscible liquids (OL), ultra low volume liquids (UL), emulsifiable concentrates (EC), dispersible concentrates"(DC), emulsions (both oil in water (EW) and water in oil (EO)), micro-emulsions (ME), suspension concentrates (SC), aerosols, fogging/smoke foR""ulations, capsule suspensions (CS) and seed treatment foR""ulations. The foR""ulation type chosen in any instance will depend upon the particular purpose envisaged and the physical, chemical and biological properties of the compound of foR""ula (1). Dustable powders (DP) may be prepared by mixing a compound of foR""ula (1) with one or more solid diluents (for example natural clays, kaolin, pyrophyllite, bentonite, alumina, montmorillonite, kieselguhr, chalk, diatomaceous earths, calcium phosphates, calcium and magnesium carbonates, sulphur, lime, flours, talc and other organic and inorganic solid carriers) and mechanically grinding the mixture to a fine powder. Soluble powders (SP) may be prepared by mixing a compound of foR""ula (1) with C3-6one or more water-soluble inorganic salts (such as sodium bicarbonate, sodium carbonate or magnesium sulphate) or one or more water-soluble organic solids (such as a polysaccharide) and, optionally, one or more wetting agents, one or more dispersing agents or a mixture of said agents to improve water dispersibility/solubility. The mixture is then ground to a fine powder. Similar compositions may also be granulated to foR"" water soluble granules (SG). Wettable powders (WP) may be prepared by mixing a compound of foR""ula (1) with one or more solid diluents or carriers, one or more wetting agents and, preferably, one or more dispersing agents and, optionally, one or more suspending agents to facilitate the dispersion in liquids. The mixture is then ground to a fine powder. Similar compositions may also be granulated to foR"" water dispersible granules (WG). Granules (GR) may be foR""ed either by granulating a mixture of a compound of foR""ula (1) and one or more powdered solid diluents or carriers, or from pre-foR""ed blank granules by absorbing a compound of foR""ula (1) (or a solution thereof, in a suitable agent) in a porous granular material (such as pumice, attapulgite clays, fuller's earth, kieselguhr, diatomaceous earths or ground corn cobs) or by adsorbing a compound of foR""ula (1) (or a solution thereof, in a suitable agent) on to a hard core material (such as sands, silicates, mineral carbonates, sulphates or phosphates) and drying if necessary. Agents which are commonly used to aid absorption or adsorption include solvents (such as aliphatic and aromatic petroleum solvents, alcohols, ethers, ketones and esters) and sticking agents (such as polyvinyl acetates, polyvinyl alcohols, dextrins, sugars and vegetable oils). One or more other additives may also be included in granules (for example an emulsifying agent, wetting agent or dispersing agent). Dispersible Concentrates (DC) may be prepared by dissolving a compound of foR""ula (1) in water or an organic solvent, sych as a ketone, alcohol or glycol ether. These solutions may contain a surface active agent (for example to improve water dilution or prevent crystallisation in a spray tank). Emulsifiable concentrates (EC) or oil-in-water emulsions (EW) may be prepared by dissolving a compound of foR""ula (1) in an organic solvent (optionally containing one or more wetting agents, one or more emulsifying agents or a mixture of said agents). Suitable organic solvents for use in ECs include aromatic hydrocarbons (such as alkylbenzenes or alkylnaphthalenes, exemplified by SOLVESSO 100, SOLVESSO 150 and SOLVESSO 200; SOLVESSO is a Registered Trade Mark), ketones (such as cyclohexanone or methylcyclo-hexanone), alcohols (such as benzyl alcohol, furfuryl alcohol orbutanol), N-alkylpyr-rolidones (such as Ar-methylpyrrolidone or N-octylpyrrolidone), dimethyl amides of fatty acids (such as C8-C10 fatty acid dimethylamide) and chlorinated hydrocarbons. An EC product may spontaneously emulsify on addition to water, to produce an emulsion with sufficient stability to allow spray application through appropriate equipment. Preparation of an EW involves obtaining a compound of foR""ula (1) either as a liquid (if it is net a liquid at room temperature, it may be melted at a reasonable temperature, typically below 70°C) or in solution (by dissolving it in an appropriate solvent) and then emulsifying the resultant liquid or solution into water containing one or more SFAs, under high shear, to produce an emulsion. Suitable solvents for use in EWs include vegetable oils, chlorinated hydrocarbons (such as chlorobenzenes), aromatic solvents (such as alkylbenzenes or alkylnaphthalenes) and other appropriate organic solvents that have a low solubility in water. Microemulsions (ME) may be prepared by mixing water with a blend of one or more solvents with one or more SFAs, to produce spontaneously a theR""odynamically stable isotropic liquid foR""ulation. A compound of foR""ula (1) is present initially in either the water or the solvent/SFA blend. Suitable solvents for use in MEs include those hereinbefore described for use in in ECs or in EWs. An ME may be either an oil-in-water or a water-in-oil system (which system is present may be deteR""ined by conductivity measurements) and may be suitable for mixing water-soluble and oil-soluble pesticides in the same foR""ulation. An ME is suitable for dilution into water, either remaining as a microemulsion or foR""ing a conventional oil-in-water emulsion. Suspension concentrates (SC) may comprise aqueous or non-aqueous suspensions of finely divided insoluble solid particles of a compound of foR""ula (1). SCs may be prepared by ball or bead milling the solid compound of foR""ula (1) in a suitable medium, optionally with one or more dispersing agents, to produce a fine particle suspension of the compound. One or more wetting agents may be included in the composition and a suspending agent may be included to reduce the rate at which the particles settle. Alternatively, a compound of foR""ula (1) may be dry milled and added to water, containing agents hereinbefore described, to produce the desired end product. Aerosol foR""ulations comprise a compound of foR""ula (1) and a suitable propellant (for example ^-butane). A compound of foR""ula (1) may also be dissolved or dispersed in a suitable medium (for example water or a water miscible liquid, such as rc-propanol) to provide compositions for use in non-pressurised, hand-actuated spray pumps. A compound of foR""ula (1) may be mixed in the dry state with a pyrotechnic mixture to foR"" a composition suitable for generating, in an enclosed space, a smoke containing the compound. Capsule suspensions (CS) may be prepared in a manner similar to the preparation of EW foR""ulations but with an additional polymerisation stage such that an aqueous dispersion of oil droplets is obtained, in which each oil droplet is encapsulated by a polymeric shell and contains a compound of foR""ula (1) and, optionally, a carrier or diluent therefor. The polymeric shell may be produced by either an interfacial polycondensation reaction or by a coacervation procedure. The compositions may provide for controlled release of the compound of foR""ula (1) and they may be used for seed treatment. A compound of foR""ula (!) may also be foR""ulated in a biodegradable polymeric matrix to provide a slow, controlled release of the compound. A composition may include one or more additives to improve the biological perfoR""ance of the composition (for example by improving wetting, retention or distribution on surfaces; resistance to rain on treated surfaces; or uptake or mobility of a compound of foR""ula (1)). Such additives include surface active agents, spray additives based on oils, for example certain mineral oils or natural plant oils (such as soy bean and rape seed oil), and blends of these with other bio-enhancing adjuvants (ingredients which may aid or modify the action of a compound of foR""ula (1)). A compound of foR""ula (1) may also be foR""ulated for use as a seed treatment, for example as a powder composition, including a powder for dry seed treatment (DS), a water soluble powder (SS) or a water dispersible powder for slurry treatment (WS), or as a liquid composition, including a flowable concentrate (FS), a solution (LS) or a capsule suspension (CS). The preparations of DS, SS, WS, FS and LS compositions are very similar to those of, respectively, DP, SP, WP, SC and DC compositions described above. Compositions for treating seed may include an agent for assisting the adhesion of the composition to the seed (for example a mineral oil or a film-foR""ing barrier). Wetting agents, dispersing agents and emulsifying agents may be SFAs of the cationic, anionic, amphoteric or non-ionic type. Suitable SFAs of the cationic type include quaternary ammonium compounds (for example cetyltrimethyl ammonium bromide), imidazolines and amine salts. Suitable anionic SFAs include alkali metals salts of fatty acids, salts of aliphatic monoesters of sulphuric acid (for example sodium lauryl sulphate), salts of sulphonated aromatic compounds (for example sodium dodecylbenzenesulphonate, calcium dodecyl-benzenesulphonate, butylnaphthalene sulphonate and mixtures of sodium di-isopropyl- and tri-/sc,propyl-naphthalene sulphonates), ether sulphates, alcohol ether sulphates (for example sodium laureth-3-sulphate), ether carboxylates (for example sodium laureth-3-carboxylate), phosphate esters (products from the reaction between one or more fatty alcohols and phosphoric acid (predominately mono-esters) or phosphorus pentoxide (predominately di-esters), for example the reaction between lauryl alcohol and tetraphosphoric acid; additionally these products may be ethoxylated), sulphosuccinamates, paraffin or olefine sulphonates, taurates and lignosulphonates. Suitable SFAs of the amphoteric type include-betaines, propionates and glycinates. Suitable SFAs of the non-ionic type include condensation products of alkylene oxides, such as ethylene oxide, propylene oxide, butylene oxide or mixtures thereof, with fatty alcohols (such as oleyl alcohol or cetyl alcohol) or with alkylphenols (such as octylphenol, nonylphenol or octylcresol); partial esters derived from long chain fatty acids or hexitol anhydrides; condensation products of said partial esters with ethylene oxide; block polymers (comprising ethylene oxide and propylene oxide); alkanolamides; simple esters (for example fatty acid polyethylene glycol esters); amine oxides (for example lauryl dimethyl amine oxide); and lecithins. Suitable suspending agents include hydrophilic colloids (such as polysaccharides, polyvinylpyrrolidone or sodium carboxymethylcellulose) and swelling clays (such as bentonite or attapulgite). A compound of foR""ula (1) may be applied by any of the known means of applying fungicidal compounds. For example, it may be applied, foR""ulated or unfoR""ulated, to any part of the plant, including the foliage, stems, branches or roots, to the seed before it is planted or to other media in which plants are growing or are to be planted (such as soil surrounding the roots, the soil generally, paddy water or hydroponic culture systems), directly or it may be sprayed on, dusted on, applied by dipping, applied as a cream or paste foR""ulation, applied as a vapour or applied through distribution or incorporation of a composition (such as a granular composition or a composition packed in a water-soluble bag) in soil or an aqueous environment. A compound of foR""ula (1) may also be injected into plants or sprayed onto vegetation using electrodynamic spraying techniques or other low volume methods, or applied by land or aerial irrigation systems. Compositions for use as aqueous preparations (aqueous solutions or dispersions) are generally supplied in the foR"" of a concentrate containing a high proportion of the active ingredient, the concentrate being added to water before use. These concentrates, which may include DCs, SCs, ECs. EWs, MEs SGs, SPs, WPs, WGs and CSs, are often required to withstand storage for prolonged periods and, after such storage, to be capable of addition to water to foR"" aqueous preparations which remain homogeneous for a sufficient time to enable them to be applied by conventional spray equipment. Such aqueous preparations may contain varying amounts of a compound of foR""ula (1) (for example 0.0001 to 10%, by weight) depending upon the purpose for which they are to be used. A compound of foR""ula (1) may be used in mixtures with fertilisers (for example nitrogen-, potassium- or phosphorus-containing fertilisers). Suitable foR""ulation types include granules of fertiliser. The mixtures suitably contain up to 25% by weight of the compound of foR""ula (1). The invention therefore also provides a fertiliser composition comprising a fertiliser and a compound of foR""ula (1). The compositions of this invention may contain other compounds having biological activity, for example micronutrients or compounds having similar or complementary fungicidal activity or which possess plant growth regulating, herbicidal, insecticidal, nematicidal or acaricidal activity. By including another fungicide, the resulting composition may have a broader spectrum of activity or a greater level of intrinsic activity than the compound of foR""ula (1) alone. Further the other fungicide may have a synergistic effect on the fungicidal activity of the compound of foR""ula (1). The compound of foR""ula (1) may be the sole active ingredient of the composition or it may be admixed with one or more additional active ingredients such as a pesticide, fungicide, synergist, herbicide or plant growth regulator where appropriate. An additional active ingredient may: provide a composition having a broader spectrum of activity or increased persistence at a locus; synergise the activity or complement the activity (for example by increasing the speed of effect or overcoming repellency) of the compound of foR""ula (1); or help to overcome or prevent the development of resistance to individual components. The particular additional active ingredient will depend upon the intended utility of the composition. Examples of fungicidal compounds which may be included in the composition of the invention are AC 382042 (N-(l-cyano-l,2-dimethylpropyl)-2-(2,4-dichlorophenoxy) pro-pionamide), acibenzolar-S-methyl, alanycarb, aldimorph, anilazine, azaconazole, azafenidin, azoxystrobin, benalaxyl, benomyl, benthiavalicarb, biloxazol, bitertanol, blasticidin S, boscalid (new name for nicobifen), bromuconazole, bupirimate, captafol, captan, carbendazim, carbendazim chlorhydrate, carboxin, carpropamid, carvone, CGA 41396, CGA 41397, chinomethionate, chlorbenzthiazone, chlorothalonil, chlorozolinate, clozylacon, copper containing compounds such as copper oxychloride, copper oxyquinolate, copper sulphate, copper tallate, and Bordeaux mixture, cyamidazosulfamid, cyazofamid (IKF-916), cyflufenamid, cymoxanil, cyproconazole, cyprodinil, debacarb, di-2-pyridy1 disulphide 1,1-dioxide, dichlofluanid, diclocymet, diclomezine, dicloran, diethofencarb, difenoconazole, difenzoquat, diflumetorim, 0,0-di-iso-propyl-S-benzyl thiophosphate, dimefluazole, dimetconazole, dimethirimol, dimethomorph, dimoxystrobin, diniconazole, dinocap, dithianon, dodecyl dimethyl ammonium chloride, dodemorph, dodine, doguadine, edifenphos, epoxiconazole, ethaboxam, ethirimol, ethyl (Z)-H-benzyl-N([methyl(methyl-thioethylideneaminooxycarbonyl)amino1thio)-β-alaninate, etridiazole, famoxadone, fenamidone, fenarimol, fenbuconazole, fenfuram, fenhexamid, fenoxanil (AC 382042), fenpiclonil, fenpropidin, fenpropimorph, fentin acetate, fentin hydroxide, ferbam, ferimzone, fluazinam, fludioxonil, flumetover, flumorph, fluoroimide, fluoxastrobin, fluquinconazole, flusilazole, flusulfamide, flutolanil, flutriafol, folpet, fosetyl-aluminium, fuberidazole, furalaxyl, furametpyr, guazatine, hexaconazole, hydroxyisoxazole, hymexazole, imazalil, imibenconazole, iminoctadine, iminoctadine triacetate, ipconazole, iprobenfos, iprodione, iprovalicarb, isopropanyl butyl carbamate, isoprothiolane, kasugamycin, kresoxim-methyl, LY186054, LY211795, LY 248908, mancozeb, maneb, mefenoxam, mepanipyrim, mepronil, metalaxyl, metalaxyl M, metconazole, metiram, metiram-zinc, metominostrobin, metra-fenone, MON65500 N-allyl-4,5-dimethyl-2-trimethylsilyIthiophene-3-carboxamide), myc-lobutanil, NTN0301, neoasozin, nickel dimethyldithiocarbamate, nitrothale-isopropyl, nuarimol, ofurace, organomercury compounds, orysastrobin, oxadixyl, oxasulfuron, oxolinic acid, oxpoconazole, oxycarboxin, pefurazoate, penconazole, pencycuron, phenazin oxide, phosphorus acids, phthalide, picoxystrobin, polyoxin D, polyram, probenazole, prochloraz, procymidone, propamocarb, propamocarb hydrochloride, propiconazole, propineb, propionic acid, proquinazid, prothioconazole, pyraclostrobin, pyrazophos, pyrifenox, pyrimethanil, pyroquilon, pyroxyfur, pyrrolnitrin, quaternary ammonium compounds, quinomethionate, quinoxyfen, quintozene, silthiofam (MON 65500), S-imazalil, simeconazole, sipconazole, sodium pentachlorophenate, spiroxamine, streptomycin, sulphur, tebuconazole, tecloftalam, tecnazene, tetraconazole, thiabendazole, thifluzamide, 2-(thiocyanomethylthio)-benzothiazole, thiophanate-methyl, thiram, tiadinil, timibenconazole, tolclofos-methyl, tolylfluanid, triadimefon, triadimenol, triazbutil, triazoxide, tricyclazole, tridemorph, trifloxystrobin, triflumizole, triforine, triticonazole, validamycin A, vapam, vinclozolin, XRD-563, zineb, ziram, zoxamide and compounds of the foR""ulae: The compounds of foR""ula (1) may be mixed with soil, peat or other rooting media for the protection of plants against seed-borne, soil-borne or foliar fungal diseases. Some mixtures may comprise active ingredients, which have significantly different physical, chemical or biological properties such that they do not easily lend themselves to the same conventional foR""ulation type. In these circumstances other foR""ulation types may be prepared. For example, where one active ingredient is a water insoluble solid and the other a water insoluble liquid, it may nevertheless be possible to disperse each active ingredient in the same continuous aqueous phase by dispersing the solid active ingredient as a suspension (using a preparation analogous to that of an SC) but dispersing the liquid active ingredient as an emulsion (using a preparation analogous to that of an EW). The resultant composition is a suspoemulsion (SE) foR""ulation. The invention is illustrated by the following Examples in which the following abbreviations are used: Step 1 Methyl 2-amino-3-pyrazine carboxylate (2.2 g) was dissolved in dry DC1-4(20 ml) to give a cloudy pale yellow solution, and pyridine (2 ml) in dry DC1-4(12 ml) was added. The stirred suspension was cooled in an ice bath, and 2,4,6-trifluorophenylacetyl chloride β.0 g) in dry DC1-4(13 ml) was added dropwise. The reaction gradually became a deep orange, and then went clear. It was stirred for 6 hours and stood overnight. The reaction mixture was washed with water, brine, and then dilute hydrochloric acid, and the DC1-4layer was dried over magnesium sulphate. The solvent was evaporated to yield an orange solid which was triturated with ether, to give methyl 2-[2,4,6-trifluorophenylacetylamino1-3-pyrazine carboxylate as a yellow solid (1.5 g). lU NMR (CDC13) 5ppm: 4.03 (s,5H), 6.74 (t,2H), 8.43 (d,lH), 8.61 (d,lH) 10.9 (s.lH). Step 2 The product of Step 1 β.25 g) was dissolved in DMF (10ml) and added dropwise to a stirred suspension of sodium hydride (0.60 g of an 80% dispersion in mineral oil) in DMF (80 mJ). There was an immediate reaction, and the mixture was stirred at room temperature for 2 hours, and at 80°C for 8 hours. The reaction mixture was cooled and evaporated to give a yellow solid β g), which was then acidified with dilute hydrochloric acid. The resultant white suspension was filtered and collected, washed with ether and dried to give 6,8-dihydroxy-7-(2,4,6-trifluorophenyl)pyrido[2,3-b1pyrazine (1.8 g). 1H NMR (d6-DMSO) 5 ppm: 7.25 (t,2H), 8.6 (fd,lH),8.7 (fd,lH), 12.6 (s,lH). Step 3 The product from Step 2 (0.90 g) was added portion-wise to phosphorus oxychloride (10 ml) with stirring. The reaction was exotheR""ic. The mixture became brown with a fine suspension, and was then refluxed for 6 hours. Excess phosphorus oxychloride was evaporated, the mixture was diluted with DC1-4, and then washed with water to give a black oil, which was purified by flash column chromatography on silica gel (40-60) eluting with diethyl ether, to give 6,8-dichloro-7-(2,4,6-trifluorophenyl)pyrido[2,3-b1pyrazine as a dark oil (0.40g). maintained at a temperature between 79°- 81°C. Stirring was continued at this temperature for 3 hours, and the reaction was then cooled. The mixture was poured carefully into saturated sodium bicarbonate solution (500 ml) keeping the temperature below 30 °C. After stirring for 20 minutes the product was extracted with ethyl acetate, washed with water and brine and dried over sodium sulphate. The solvent was evaporated to yield a dark red oil, which was purified by flash chromatography eluting with cyclohexanerethyl acetate, 4:1 to give 6,8-dichloro-7-(2,4,6-trifluorophenyl)pyrido[2,3-b1pyrazine as a light brown solid (7.5 g),m.p. 139-141 °C A fraction containing a mixture of isomers (0.080 g), was obtained, and a portion of this mixture (0.020g) was purified by reverse phase HPLC on a Kromasil 100-5C18 column, eluting with methanol:water (65:35) to give [6-chloro-7-(2,4,6-trifluorophenyl)-pyrido[2,3-b1pyrazin-8-yl1-isopropylamine as a frothy solid (0.013 g). 1H NMR (CDC13) 5 ppm: 1.1 (d,6H), 3.26 (m,lH), 6.84 (m,2H), 6.95 (bd.lH), 8.67 (d.lH), 9.0 (d,lH). Step 1 6,8-Dichloro-7-(2,4,6-trifluoropheny1)-pyrido[2,3-b1pyrazine (1.25 g) and potassium fluoride (0.66 g, spray dried) in dry sulpholane (5 ml) were heated to 130 °C for 16 hours. The reaction mixture was poured into water and extracted with ethyl acetate. The extract was washed with water and brine and dried over sodium sulphate. After evaporation of the solvent, the remaining oil was purified by flash chromatography on silica gel eluting with cyclohexanerethyl acetate, 3:1 to yield 6,8-difluoro-7-(2,4,6-trifluorophenyl)-pyrido[2,3-b1-pyrazine as a slightly brownish solid (0.79 g), m.p. 120-121 °C. Step 2 The product from Step 1 (0.30 g) was added to a suspension of isopropylamine (0.090 g), potassium carbonate (0.21 g) and a catalytic amount of DMAP in DMF β ml), and the mixture was stirred at room temperature for 19 hours. After addition of ethyl acetate, the mixture was washed with water and brine, dried over sodium sulphate, filtered and the solvent evaporated. The residue was purified by flash chromatography eluting with toluene:ethyl acetate, 9:1 to give [6-fluoro-7-(2,4,6-trifluorophenyl)-pyrido[2,3-b1pyrazin-8-yl1-isopropylamine as a yellow powder (0.20 g), m.p. 127-128 °C. A solution of 4-aminopyridazine-3-carbonitrile (0.248 g, prepared as in J. Het. Chem.(-910), 3, 467-473) in absolute ethanol β0 ml)was saturated with hydrogen chloride gas, the flask being cooled in an ice bath. The ice bath was then removed and the resulting solution was refluxed for 18 hours. It was then cooled, the solvent evaporated, and cold, saturated aqueous sodium bicarbonate was added. The aqueous phase was then extracted with DC1-4, the organic phases were combined, dried over magnesium sulphate, filtered and evaporated to give 4-aminopyridazine-3-carboxy1ic acid ethyl ester as a white solid (0.229g). The aqueous phase was evaporated, DC1-4was added, the organic phase was isolated, dried over magnesium sulphate, filtered and evaporated under vacuo to give further ester as a white solid (0.010 g), m.p. 149-150°C. 1H NMR (CDC13) 6ppm: 1.48 (t,3H), 4.52 (q,2H), 6.73 (d,lH), 8.75 (d,lH). Step 2 A mixture of the product from Step 1 (0.239 g) and DMAP (0.175 g) in dry toluene (1 ml) was added to 2,4,6-trifluorophenylacetyl chloride (crude product from reaction of 0.275 g 2,4,6-trifluorophenylacetic acid and oxalyl chloride) and a few drops of DMF in toluene (1 ml) at room temperature, giving a thick yellow precipitate. The stirred suspension was heated for 3 hours at reflux, becoming dark brown/green with a green precipitate. It was left to stand overnight for 18 hours. The solid was collected and washed with diethyl ether. The dark green filtrate was evaporated to give a dark green liquid which was purified by flash column chromatography on silica gel (40-60) eluting with ethyl acetate to give 4-[2-(2,4,6-trifluorophenyl)-acetylamino1-pyridazine-3-carboxylic acid ethyl ester as green/yellow oil that solidified on standing (0.307 g). 1H NMR (CDCb) 5 ppm: 1.50 (t,3H), 3.87 (s,2H), 4.55 (q,2H), 6.77 (t,2H), 8.78 (d,lH), 9.15 (d,lH), 11.20(bs,lH). Step 3 The product from Step 2 (0.307 g) and potassium carbonate (0.25 g) were stirred in dry DMF (10 ml) at 110°C for 2 hours and then cooled and stood for 18 hours. The DMF was evaporated and the resulting brown solid was triturated with diethyl ether and the organic phase decanted. The solid was dissolved in water then acidified with dilute hydrochloric acid to neutrality. Most of the aqueous phase was then evaporated, leading to precipitation of a black solid that was filtered, and the yellow/brown aqueous phase was evaporated to dryness, affording a residue that was dissolved in methanol, the insoluble inorganic salts were filtered and the organic phase was evaporated to dryness to give 7- (2,4,6-trifluorophenyl)-5H-pyrido[3,2-c1pyridazine-6,8-dione as a light brown/beige solid (0.258 g). 'H NMR (CD3OD) 5 ppm: 6.83 (2d,2H), 7.44 (d.lH), 9.00 (d,lH). Step 4 Phosphorus oxychloride (0.048 ml) was added to the product from Step 3 (0.05 g) in 1,2-dichloroethane (2 mJ) containing a catalytic amount of DMF. The suspension was stirred and refluxed for 1 hour and then stood for 18 hours, and then refluxed for a further hour and then allowed to cool. The excess phosphorus oxychloride was evaporated to give a brown oil, which was dissolved in DC1-4and washed with cold water. The organic layer was separated and dried over magnesium sulphate, filtered and evaporated to give a brown oil, which was purified by flash column chromatography on silica gel (40-60) eluting with diethyl ether to give 6,8-dichloro-7-(2,4,6-trifluorophenyl)-pyrido[3,2-c1pyridazine as a yellow oil (0.015 g). 1H NMR (CDC13) 5 ppm: 6.92 (m,2H), 8.11 (d,lH), 9.71 (d,lH). Step 5 Isopropylamine (0.5 ml) was added to the product from Step 4 (0.015 g) dissolved in DC1-4(1ml) containing dimethylacetamide (0.3 ml) in a sealed tube. The yellow solution became yellow/greenish. The vessel was then sealed and stirred at room temperature. The solvents were evaporated and the crude residue was purified using preparative thin layer chromatography silica gel plates eluting with ethyl acetateihexane 1:1 .to^give [6-Chloro-7-(2,4,6-trifluorophenyl)-pyrido[3,2-c1pyridazin-8-yl1-isopropylamine (0.003 g). 'H NMR (CDCI3) 8 ppm: 1.16 (d,6H), 3.41 (m,lH), 6.85 (dd,2H), 7.79 (bsJH), 7.84 (d,lH). 9.40 (d,lH). Step 1 5-Aminopyridazine-4-carboxylic acid ethyl ester (1.26 g, prepared according to J. Het. Chem., (1968), 5, 845) was dissolved in dry toluene (125 ml) at 90°C, and DMAP (0.92- g) was added. 2,4,6-Trifluorophenylacety1 chloride (1.75 g of 95% purity material) was added dropwise with stirring at 70°C, and a white solid precipitated. The reaction was stirred at reflux for 5 hours and then filtered hot. The filtrate was evaporated to give 5-[2-(2,4,6-trifluorophenyl)-acetylamino1-pyridazine-4-carboxylic acid ethyl ester as a white solid (2.6 g),m.p. 143-144°C JH NMR (CDC13) 5 ppm: 1.45 (t,3H), 3.90 (s,2H), (4.45 (q,2H), 6.75 (m,2H), 9.45 (slH), 10.60 (s,lH), 11.1 (bs,lH). Step 2 The product from Step 1 (2.5 g) was dissolved in dry THF (50 ml) and the flask purged with nitrogen. Sodium bis-trimethylsilylamide (22.1 ml of a 1M solution in THF) was added dropwise with stirring at 0°C. A yellow precipitate appeared, and the reaction was stirred for 3 hours at 0°C. The reaction was quenched with concentrated hydrochloric acid (5 ml) at 0°C and then poured onto ice water, extracted with DC1-4and dried over magnesium sulphate. The solvent was evaporated to give 3-(2,4,6-trifluorophenyl)-l#-pyrido[2,3-d1pyridazine-2,4-dione as a yellow solid. Further product crystallised out of the aqueous solution overnight, to give a total yield of 1.29 g, m.p. >300°C. 1H NMR (d6-DMSO) 5 ppm: 7.25 (m,2H), 9.17 (s,lH), 9.47 (s,lH), 12.30 (bs,lH). Step 3 The product from Step 2 (0.10 g) was heated to 90°C with phosphorus oxychloride (1.6 ml) with stirring. After 1 hour a clear yellow solution was obtained and the excess solvent was evaporated and ice water was added, giving a yellow solid. This was extracted with DC1-4, and the solution dried over magnesium sulphate and evaporated to give 2,4-dichloro-3-(2,4,6-trifluorophenyl)-pyrido[2,3-d1pyridazine as a yellow foamy glass (0.11 g). 1H NMR (CDCI3) 5 ppm: 6.90 (m,2H), 9.80 (s,lH), 10.0 (s, H). Step 4 Isopropylamine (1.5 ml) was added to the product from Step 3 (0.020 g) in DC1-4and the tube stoppered and the reaction stirred overnight at room temperature. The DC1-4was evaporated and water added to the residue, which was then extracted with DC1-4. The extract was dried over magnesium sulphate and evaporated to give an orange oil, which was purified by HPLC eluting with ethyl acetate:hexane 4:1 to give [2-Chloro-3-(2,4,6-trifluorophenyI)-pyrido[2,3-d1pyridazin-4-yl1-isopropy1arnine (0.007 g) 1H NMR (CDC13) 8 ppm: 1.27 (d,6H), 4.05 (m, 1H), 4.90 (bs, 1H), 6.92 (m,2H), 9.55 (s, 1H), 9.90 (s,lH). Step 1 3-Aminopyridazine-4-carboxylic acid (1.68 g, prepared as in JOC, (1985), 50, 346) was refluxed in ethanol (170 ml) with concentrated hydrochloric acid (2 ml) and p-toluene-sulphonyl chloride (0.1 g) for 55 hours. The solvent was evaporated and ice water added to the residue, which was then neutralised with solid sodium bicarbonate. The mixture was extracted with chlorofoR"", insoluble material filtered, the organic extract dried over magnesium sulphate and evaporated to give 3-aminopyridazine-4-carboxylic acid ethyl ester (1.02 g) as a white solid. 1H NMR (CDC13) 8 ppm: 1.40 (t,3H), 4.40 (q,2H), 6.50 (bs,2H), 7.74 (d,lH), 8.72 (d,lH). Step 2 The product from Step 1 (0.36g) was dissolved in dry toluene (25 ml) and DMAP (0.262 g) was added. A solution of 2,4,6-trifluorophenylacetyl chloride (0.45 g) in dry toluene (1 ml) was added dropwise with stirring, and a white precipitate foR""ed. After stirring at room temperature for 10 minutes the reaction was stirred under reflux for 4.5 hours, and then allowed to stand overnight at room temperature. The white solid was filtered and washed with toluene, and the filtrate evaporated to give a brown oil, which was purified by HPLC eluting with ethyl acetateihexane 4:1 to give 3-[2-(2,4,6-trifluorophenyl)-acetylamino1-pyridazine-4-carboxylic acid ethyl ester as a pale yellow solid (0.57 g), m.p. 135°C. 1H NMR (CDCI3) 8 ppm: 1.40 (t,3H), 4.22 (s,2H), 4.41 (q,2H), 6.70 (m,2H), 7.94 (d,lH), 9.15 (d,lH), 10.30 (bs,lH). Step 3 The product from Step 2 (2.0 g) was dissolved in dry THF (50 ml), and sodium bis-trimethylsilylamide (17.7 ml of a 1.0M solution in THF) was added dropwise with stirring under nitrogen at 0°C. The reaction was stirred for 3 hours at 0°C and a yellow precipitate was foR""ed. The reaction was quenched with concentrated hydrochloric acid and then poured into ice water. The solid was filtered, washed with water and air dried to give 6-(2,4,6-trifluorophenyl)-8H-pyrido[2,3-c1pyridazine-5,7-dione as a yellow solid (1.9 2g), m.p. >330°C, still containing some THF, which was used without further purification. 1H NMR (D6-DMSO) 5 ppm: 7.30 (m,2H), 8.10 (d,lH), 9.20 (d,lH), 11.90 (bsJH), 12.60 (s,lH). Step 4 The product from Step 3 (0.060 g) was heated to 90°C in phosphorus oxychloride (1 ml) for 1 hour to give a clear black solution. The mixture was cooled and the excess in phosphorus oxychloride evaporated. The residue was quenched with ice and aqueous sodium bicarbonate, extracted with ethyl acetate, the extract dried over magnesium sulphate and evaporated to give 5,7-dichloro-6-(2,4,6-trifluorophenyl)-pyrido[2,3-c1pyridazine as a black solid (0.087 g). 1H NMR (CDC13) 5 ppm: 6.90 (m,2H), 8.30 (d,lH), 9.75 (d,lH). Step 4 The product from Step 3 (0.080 g) was stirred with isopropylamine (2 ml) in DC1-4(5 ml) at room temperature overnight and then heated to 40°C in a sealed tube for 4 hours. The volatiles were evaporated, water was added and the mixture extracted with DC1-4. The extracts were dried over magnesium sulphate and evaporated to give a dark brown tar, which was purified by preparative TLC on silica gel plates eluting with ethyl acetate:hexane 3:2 to give [7-Ch1oro-6-(2,4,6-trifluorophenyl)-pyrido[2,3-c1pyridazin-5-yl1-isopropylamine (0.008 g), !H NMR (CDCI3) 5 ppm: 1.20 (d,6H), 3.71 (m,lH), 4.45 (bs,lH), 6.87-6.92 (m,2H), 7.97 (d,lH), 9.37 (d,lH). Compounds were tested in a leaf disk assay, with methods described below. Test i i compounds were dissolved in DMSO, and diluted into water to 200 ppm. Plasmopara viticola (downy mildew of grapevine): grapevine leaf disks were placed on agar in a 24-well plate arid sprayed a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the fungus. After appropriate incubation the activity of a compound was assessed seven days after inoculation as preventive fungicidal activity. Phytophthora infestans (late blight of potato on tomato): tomato leaf disks were placed on water agar in a 24-well plate and sprayed with a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with - a spore suspension of the fungus. After appropriate incubation the activity of a compound was assessed four days after inoculation as preventive fungicidal activity. Erysiphe graminisf.sp. hordei (barley powdery mildew): barley leaf segments were placed on agar in a 24-well plate and sprayed with a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the fungus. After appropriate incubation the activity of a compound was assessed four days after inoculation as preventive fungicidal activity. Erysiphe graminisf.sp. tritici (wheat powdery mildew): wheat leaf segments were placed on agar in a 24-well plate and sprayed with a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the fungus. After appropriate incubation the activity of a compound was assessed four days after inoculation as preventive fungicidal activity. Puccinia reconditaf.sp. tritici (wheat brown rust): wheat leaf segments were placed on agar in a 24-well plate and sprayed with a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the fungus. After appropriate incubation the activity of a compound was assessed nine days after inoculation as preventive fungicidal activity. Septoria nodorum (wheat glume blotch): wheat leaf segments were placed on agar in a 24-well plate and sprayed with a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the fungus. After appropriate incubation the activity of a compound was assessed four days after inoculation as preventive fungicidal activity. Pyrenophora teres (barley net blotch): barley leaf segments were placed on agar in a 24-well plate and sprayed with a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the fungus. After appropriate incubation the activity of a compound was assessed four days after inoculation as preventive fungicidal activity. Pyricularia oryzae (rice blast): rice leaf segments were placed on agar in a 24-well plate and sprayed with a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the fungus. After appropriate incubation the activity of a compound was assessed four days after inoculation as preventive fungicidal activity. Botrytis cinerea (grey mould): bean leaf disks were placed on agar in a 24-well plate and sprayed with a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the fungus. After appropriate incubation the activity of a compound was assessed four days after inoculation as preventive fungicidal activity. The following compounds gave greater than 60% control of disease: Plasmopara viticola, Compounds 4 (1), 20 (1), 23 (5); Phytophthora infestans, Compounds 3 (1), 58 (5), 3 (103); on agar in a 24-well plate and sprayed with a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the fungus. After appropriate incubation the activity of a compound was assessed four days after inoculation as preventive fungicidal activity. Puccinia reconditaf.sp. tritici (wheat brown rust): wheat leaf segments were placed on agar in a 24-well plate and sprayed with a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the fungus. After appropriate incubation the activity of a compound was assessed nine days after inoculation as preventive fungicidal activity. Septoria nodorum (wheat glume blotch): wheat leaf segments were placed on agar in a 24-well plate and sprayed with a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the fungus. After appropriate incubation the activity of a compound was assessed four days after inoculation as preventive fungicidal activity. Pyrenophora teres (barley net blotch): barley leaf segments were placed on agar in a 24-well plate and sprayed with a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the fungus. After appropriate incubation the activity of a compound was assessed four days after inoculation as preventive fungicidal activity. Pyricularia oryzae (rice blast): rice leaf segments were placed on agar in a 24-well plate and sprayed with a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the fungus. After appropriate incubation the activity of a compound was assessed four days after inoculation as preventive fungicidal activity. Botrytis cinerea (grey mould): bean leaf disks were placed on agar in a 24-well plate and sprayed with a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the fungus. After appropriate incubation the activity of a compound was assessed four days after inoculation as preventive fungicidal activity. The following compounds gave greater than 609c control of disease: Plasmopara viticola. Compounds 4 (1), 20 (1), 23 (5); Phytophthora infestans. Compounds 3 (1), 58 (5). 3 (103); Erysiphe graminis f.sp. hordei, Compounds 3 (1), 14 (1), 15 (1), 16 (1), 17 (1), 22 (1), 23 (1), 58(1), 108(1), 161 (1), 162(1), 3(5), 4(5), 17 (5), 20 (5), 22 (5), 23 (5), 28 (5), 58 (5), 108 (5), 162 (5), 171 (5), 665 β1), 23 β2), 3 β7-), 16 β7), 171 β7), 665 β7), 678 β7), 3 (43), 23 (43), 685 (43), 3 (103), 12 (103), 23 (103), 58 (103), 92 (103), 2651 (103), 2660 (103), 2671 β03), 23844 (103) diastereoisomer 1, 23844 (103) diastereoisomer 2, 23855 (103), 23890(103; Erysiphe graminis f.sp.tritici, Compounds 3 (1), 4 (1), 15 (1), 16 (1), 22 91), 23 (1), 58 (1), 108 β), 162 (1), 219 (1), 58 95), 161 (5), 3 β1). 16 β7), 665 β7), 3 (103), 12 (103), 23 (103), 58 (103), 92 (103), 2651 (103), 2660 (103j, 2671 (103), 23844 (103) diastereoisomer 1, 23844 (103) diastereoisomer 2, 23855 (103). 23890 (103); Puccinia recondita f.sp. tritici, Compounds 3 (1). 14 (1), 15 (1), 16 (1), 17 (1), 23 (1), 58 (1), 108 (1), 161 (1), 162 (1), 4 (5), 17 (5), 23 (5), 28 (5), 58 (5), 108 (5), 3 β1), 16 β7), 665 β7), 678 β7), 3 (103), 12 (103), 23 (103), 58 (103), 92 (103), 2651 (103), 2660 (103), 2671 (103), 23844 (103) diastereoisomer 1, 23855 (103), 23890 (103); Septoria nodorum, Compounds 3 91), 15(1), 16(1), 17 (1), 23 (1), 58 (1), 58 95), 161 (5), "22 (6), 665 β7), 685 (43), 12 (103), 23 (103), 58 (103), 2660 (103), 2671 (103), 23844 (103) diastereoisomer 1, 23855 (103), 23890(103); Pyrenophora teres, Compounds 3 (1), 14 (1), 15 (1), 16 (1), 17 (1), 23 (1), 58 (1), 161 (1), 3 (5), 20 (5), 16 β7), 665 β7), 3 (103), 12 (103), 23 (103), 58 (103), 2651 (103), 2660 (103), 2671 (103), 23844 (103) diastereoisomer 1,23855(103), 23890(103); - . Pyricularia oryzae, Compounds 3 (1), 4 (1), 14(1), 15(1), 16(1), 17 (1), 20 (1), 23 (1), 58 (1), 108(1), 161 (1), 3 (5), 4 (5), 20 (5), 23 (5). 58(5), 108 (5), 3 β2), 3 β7), 16 β7), 678 β7), 3 (43), 3 (103), 12 (103), 23 (103), 58 (103). 92 (103), 171 (103), 2651 (103), 2669 (103), 2671 (103), 23844 (103) diastereoisomer 1. 23844 (103) diastereoisomer 2, 23855 (103), 23890 (103); Botrytis cinerea, Compounds 4 (1), 14 (1), 15 (1). 16 (1), 17 (1), 22 (1), 58 (1). 108 (1), 4 (5), 22 (5), 28 (5), 58 (5), 108 (5), 162 (5), 16 β7). 678 β7), 23 (103), 92 (103), 2651 (103), 2660 (103), 23844 (103) diastereoisomer 2. 23855 (103), 23890 (103). CLAIMS wherein W and X, W and Z, X and Y or Y and Z are N and the other two are CR8; R8 is H, halo, C1-4 alkyl, C1-4 alkoxy or halo(C1-4)aIkyl; R is halo; R1 is halo, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-8cycloalkyl, C3_8cyc]oa]ky](C1-6)a]ky], C1-8 alkoxy, C1-8alkylthio, aryl, aryloxy, arylthio, heteroaryl, heteroaryloxy, heteroarylthio, aryl(C1-4)alkyl, ary](C1-4)a!koxy, heteroaryl(Ci-4)a]kyl, heteroaryl(C1-4)alkoxy, aryl(C]4)alkylthio, heteroary](C1-4)alkylthio, morpholino, piperidino or pyrrolidino; R2 is NR3R4; 1 A R" and R are independently H, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, aryl, aryl(C1-8)alkyl, C3.8cycloalkyl, C3.8cycloalkyl(C1-6)alkyl, heteroaryl, heteroaryl(C1-8)alkyl, NR5R6, provided that not both R3 and R4 are H or NR5R6, or R and R together form a C3-7 alkylene or C3.7 alkenylene chain optionally substituted with one or more C1-4 alkyl or C1-4 alkoxy groups, or, together with the nitrogen atom to which they are attached, R3 and R4 form a morpholine, thiomorpholine, thiomorpholine S-oxide or thiomcrpholine S-dioxide ring or a piperazine or piperazine A7-(Ci-4)alkyl (especially Af-methyl) ring: and R5 and R6 are independently H, alkyl, C2-8 alkenyl, Q-8 alkynyl, aryl, aryl(C1-8)aIkyl, C3-8cycloalkyI, C3.8cyc]oalky](C1-6)alkyl, heteroaryl or heteroaryl(Cj-8)alkyl; any of the foregoing alkyl, alkenyl, alkynyl or cycloalkyl groups or moieties (other than for R8) being optionally substituted with halogen, cyano, C1-6 alkoxy, C1-4alkylcarbonyl, alkoxycarbonyl, C1-6 haloalkoxy, C1-6 alkylthio. tri(C1-4)alkylsilyl, C1-6 alkylamino or C1-6 dialkylamino, any of the foregoing morpholine, thiomorpholine, piperidine, piperazine and pyrrolidine rings being optionally substituted with C1-4 alkyl (especially methyl), and any of the foregoing ary] or heteroaryl groups or moieties being optionally substituted with one or more substituents selected from halo, hydroxy, mercapto, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C2-6 alkenyloxy, C2-6 alkynyloxy, halo(C1-6)alkyl, halo(C1-6)alkoxy, C1-6 alkylthio, halo(C1-6)alkylthio, hydroxy(C1-6)alkyl, C1-4alkoxy(C1-6)alkyl, C3-6 cycloalkyl, C1-6 cycloalkyl(C1-4)alkyl, phenoxy, benzyloxy, benzoyloxy, cyano, isocyano, thiocyanato, isothiocyanato, nitro, -NITR"", -NHCOR"', -NHCONR'"R"", -CONR"R"", -S02R'", -OS02R,n, -COR"1, -CR" or -N=CR",R,", in which R and R,, are independently hydrogen, C1-4 alkyl, halo(C1-4)alkyl, C1-4 alkoxy, halo(C1-4)alkoxy, C1-4 alkylthio, C3 cycloalkyl, C3-6 cycloalkyl(C1-4)alkyl, phenyl or benzyl, the phenyl and benzyl groups being optionally substituted with halogen, C1-4 alkyl or C1-4 alkoxy. 2. A compound according to claim 1 wherein W and Z are N and X and Y are CH. 3. A compound according to any one of the preceding claims wherein R3 is C1-8 alkyl, halo(C|-g)alkyl, hydroxy(C1-8)alkyl, C1-4 alkoxy(C1-8)alkyl, C1-4 alkoxyhalo- (C1-8)alkyl, tri(C1-4)alkylsilyl(C1-6)alkyl, C1-4 alkylcarbonylC1-8)alkyl, C1-4 alkylcarbonyl- halo(C1-8)alkyl, phenylalkyl, C2-8 alkenyl, halo(C2-8)alkenyI, C2-8 alkynyl, C3-8 cycloalkyl optionally substituted with chloro, fluoro or methyl, C3_8cycloalkyl(C1-4)alkyl, phenylamino, piperidino or morpholino, the phenyl ring of phenylalkyl or phenylamino being optionally substituted with one, two or three substituents selected from halo, C1-4 alkyl, halo(C1-4)alkyl, C1-4 alkoxy and halo(C1-4)alkoxy; and R4 is H, C1-4 alkyl. halo(C1-4)alkyl or amino, or R and R together form a C3.7 alkylene or alkem lene chain optionally substituted with methyl, or, together with the nitrogen atom to which they are attached, R and R form a morpholine, thiomorpholine, thiomorpholine S-oxide or thiomorpholine S-dioxide ring or a piperazine or piperazine Ar-(C1-4)alkyl (especially iV-methyl) ring, in which the morpholine or piperazine rings are optionally substituted with methyl. 4. A compound according to any one of the preceding claims wherein R1 is phenyl optionally substituted with from one to five halogen atoms or with from one to three substituents selected from halo, C1-4 alkyl, halo(C1-4)alkyl, C1-4 alkoxy or halo(C1-4)alkoxy. pyridyl optionally substituted with from one to four halogen atoms or with from one to three substituents selected from halo. C1-4 alkyl, halo(C1-4)alkyl, C1-4 alkoxy or halo(C1-4)aDcoxy, 2- or 3-thienyl optionally substituted with from one to three halogen atoms or with from one to three substituents selected from halo, C1-4 alkyl, halo(C1-4)alkyl, C1-4 alkoxy or halo(C1-4)alkoxy, or piperidino or morpholino both optionally substituted with one or two methyl groups. 5. A compound according to claim 4 wherein R1 is 2,6-difluorophenyl, 2-fluoro-6-chlorophenyl, 2,5,6-trifluorophenyl, 2,4,6-trifluorophenyL 2,6-difluoro-4-methoxyphenyl or pentafluorophenyl. 6. A compound according to claim 1 wherein W and X, W and Z, X and Y or Y and Z are N and the other two are CR8; R8 is H, halo, C1-4 alkyl, C1-4 alkoxy or halo(C1-4)alkyl; R is halo; R1 is halo, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl,C3-8cycloalkyl, C3-8cycloalkyl(C1-6)alkyl, C1-8 alkoxy, C1-8 alkylthio, aryl, aryloxy, arykhio, heteroaryl, heteroaryloxy, heteroarylthio, aryl(Ci_4)alkyl, aryl(C1-4)alkoxy, heteroaryl(C1-4)alkyl, heteroaryl(C1-4)alkoxy, aryl(C1-4)- alkylthio, heteroaryl(C1-4)alkylthio, morpholino. piperidino or pyrrolidino; R2 is NR3R4; R and R are independently H, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, aryl, aryl(Ci.8)alkyl, C3-scycloalkyl, C3-8cycloalkyl(C1-6)alkyl, heteroaryl, heteroaryl(C1-8)alkyl, NR5R6, provided that not both R3 and R4 are H or NR5R6, or RJ and R together form a C3.7 alkylene or C3.7 alkenylene chain optionally substituted with one or more C1-4 alkyl or C1-4 alkoxy groups, or. together with the nitrogen atom to which they are attached. R3 and R4 form a morpholine, thiomorpholine, thiomorpholine S-oxide or thiomorpholine S-dioxide ring or a piperazine or piperazine /V-(C1-4)alkyl (especially /V-methyl) ring; and R3 and R6 are independently H, C1-8 alkyl, C2-8 alkenyl,C2-8alkynyl. aryl, arylC1-8)alkyl, C3-8cycloalkyl, C3-8cycloalkyl(C1-6)alkyl, heteroaryl or heteroaryl(C1-6)alkyI; any of the foregoing alkyl. alkenyl, alkynyl or cycloalkyl groups or moieties (other than for R8) being optionally substituted with halogen, cyano, C1-4 alkoxy, C1-4alkylcarbonyl, alkxycarbonyl, C1-6 haloalkoxy, C1-6alkylthio. tri)alkylsilyl, C1-6 alkylamino or C1-6 dialkylamino. any of the foregoing morpholine, thiomorpholine, piperidine, piperazine and pyrrolidine rings being optionally substituted with C1-4 alky] (especially methyl), and fc any of the aryl, heteroar. aryloxy or heteroaryl groups being optionally substituted with one or more substituents selected from halo, hydroxy, mercapto, alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C2-6 alkenyloxy, C2-6 alkynyloxy, halo(d-6)alkyl, halo(C1-6)alkoxy, C1-6 alkylthio, halo(C1-6)aIkylthio, hydroxy(C1-4)alkyl, C1-4alkoxy(C1-6)alkyl, C3-6 cycloalkyl, C1-6 cycloalkyl(C1-4)alkyl, phenoxy, benzyloxy, benzoyloxy, cyano, isocyano, thiocyanato, isothiocyanato, nitro, -NR'R", -NHCOR"", -NHCONR"R"", -CONR"R", -S02R","-OS02R'", -COR'", -CR"=NR'" or -N=CR,"R"', in which R,M and R,m are independently hydrogen, C1-4 alkyl, halo(C1-4)alkyl, C1-4 alkoxy, halo(C1-4j)alkoxy, C1-4 alkylthio, C3-6 cycloalkyl, C3-6 cycloalkyl(C1-4)alkyl, phenyl or benzyl, the phenyl and benzyl groups being optionally substituted with halogen, C1-4 alkyl or C1-4 alkoxy. 7. A compound according to claim 1 wherein W and X, W and Z, X and Y or Y and Z are N and the other two are CR8; R8 is H, halo, C1-4 alkyl, C1-4 alkoxy or halo(C1-4)alkyl; R is halo; R1 is halo, Cj-g alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-8 cycloalkyl, C3-8cycloalky](C1-6)alkyl, C1-8 alkoxy, Cj.g alkylthio, aryl, aryloxy, arylthio, heteroaryl, heteroaryloxy, heteroarylthio, aryl(C1-4)alkyl, aryl(C1-4)alkoxy, heteroaryl(C1-4)alkyl, heteroaryl(C1-4)alkoxy, aryl(C1-4j)alkylthio, heteroaryl(C1-4)alkylthio, morpholino, piperidino or pyrrolidino; R2 is NR3R4; R'" is C1-4 alkyl, halo(C1-4)alkyl, C2-4alkenyl, C1-6 cycloalkyl, C3-6 cycloalkyl(C1-4)alkyl or phenylamino in which the phenyl ring is optionally substituted with one, two or three substituents selected from halo, C1-4 alkyl, halo)alkyl, alkoxy and halo(C1-4)alkoxy; and R. is H, C1-4 alkyl or amino, or R*3 and R together form a C4-6 alkylene chain optionally substituted with C1-4 alkyl or C1-4 alkoxy. or, 1 A together with the nitrogen atom to which they are attached, R' and R form a morpholine, thiomorpholine, thiomorpholine S-oxide or thiomorpholine S-dioxide ring or a piperazine or piperazine AT-(C1-4)alkyl (especially TV-methyl) ring; any of the alkyl, alkenyl, alkynyl or cycloalkyl groups or moieties (other than for R8) being optionally substituted with halogen, cyano, alkoxy, C1-6alkylcarbony], C1-4alkoxycarbonyl, C1-6 haloalkoxy, C1-6 alkylthio, tri(C1-4)alkylsilyl, C,.e alkylamino or C1-4 dialkylamino, any of the foregoing morpholine, thiomorpholine, piperidine, piperazine and pyrrolidine rings being optionally substituted with C1-4 alky I (especially methyl), and any of the aryl or heteroaryl groups or moieties being optionally substituted with one or more substituents selected from halo, hydroxy, mercapto, C1-6 alky], C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C2-6 alkenyloxy,C2-6alkynyloxy, ha]o(C1-6)alkyl, halo(C1-6)alkoxy, C1-4 alkylthio, halo(C1-4)alkylthio, hydroxy(C1-4)alkyl, C1-4alkoxy(C1-6)alkyl, C3-6 cycloalkyl, C3-6cycloalkyl(C1-4)alkyl, phenoxy, benzyloxy, benzoyloxy, cyano, isocyano, thiocyanato, isothiocyanato, nitro, -NR"",R"", -NHCOR"", -NHCONR""R"" -CONR""R"", -S02R""I, -OS02R'", -COR"', -CR""=NR"" or -N=CR""R"", in which R"' and R"" are independently hydrogen, C1-4 alkyl, halo(C1-4)alkyl, C1-4 alkoxy, halo(C1-4)alkoxy, C1-4 alkylthio, C3-6 cycloalkyl, C1-6 cycloalkyI(Ci4)alkyl, phenyl or benzyl, the phenyl and benzyl groups being optionally substituted with halogen, C,A alkyl or C1-4 alkoxy. R- and R together foR"" a C3.7 alkylene or C3-7 alkenylene chain optionally substituted with one or more C1-4 alkyl or C1-4 alkoxy groups, or, together with the nitrogen atom to which they are attached, R3 and R4 foR"" a morpholine, thiomorpholine, thiomorpholine S-oxide or thiomorpholine S-dioxide ring or a piperazine or piperazine N-(C1-4)alkyl (especially N-methyl) ring; and R3 and R6 are independently H, C1-8 alky], C3-8alkenyl, C2.s alkynyl, aryl, aryl(C1_8)alkyl, C3-8cycloalkyl, C3-8 cycloalkyl(C1-6)alkyl, heteroarvl or heteroaryl)alkyl; any of the alkyl, alkenyl, alkynyl or cycloalkyl groups or moieties (other than for R8) being optionally substituted with halogen, cyano, C1-6 alkoxy, C1-4alkylcarbonyl, C1-6 alkoxycarbonyl, C1-6 haloalkoxy, C1-6 alkylthio. trifC1-4)alkylsilyl, C1-6alkylamino or C1-6 dialkylami'no, any of the foregoing morpholine, thiomorpholine, piperidine, piperazine and pyrrolidine rings being optionally substituted with C1-4 alky] (especially methyl), "and any of the aryl or heteroaryl groups or moieties, including the phenyl group of R1, being optionally substituted with one or more substituents selected from halo, hydroxy, mercapto, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-4 alkoxy, C2-6 alkenyloxy, C2-6 alkynyloxy, halo(C1-6)alkyl, ha]o(C1-6)alkoxy, C1-6alkylthio, halo(C1-6)alkylthio, hydroxy(C1-4)alkyl, C1-4alkoxy(C1-6)alkyl, C3-6 cycloalkyl, C1-6 cycloalkyl(C1-4)alkyl, phenoxy, benzyloxy, benzoyloxy, cyano, isocyano, thiocyanato, isothiocyanato, nitro, -NR""R"", -NHCOR'", -NHCONR"'R"", -CONR""R"", -S02R", -OS02R", -COR"", -CR'"=NR"" or -N=CR"",R"", in which R'" and R"" are independently hydrogen. C1.4 alky], halo(C1-4)alkyl, C1-4 alkoxy, halo(C1-4)alkoxy, C1-4 alkylthio, C3-6 cycloalkyl. C3-6 cyc]oalky](C1-4)alkyl, phenyl or benzyl, the phenyl and benzyl groups being optionally substituted with halogen, C1-4 alkyl or C1-4 alkoxy. halo(C1-4)alkoxy, pyridyl optionally substituted with from one to four halogen atoms or with from one to three substituents selected from halo. C1-4 alkyl, halo(Ci-4)alkyl, C1-4 alkoxy or halo(C1-4)alkoxy, 2- or 3-thienyl optionally substituted with from one to three halogen atoms or with from one to three substituents selected from halo, C1-4 alkyl, halo(C1-4)alkyl, C1-4 alkoxy or halo(C1-4)alkoxy, or piperidino or morpholino both optionally substituted with one or two methyl groups; R2 is NR3R4; R3 is C1.8 alkyl, halo(Cj.s)alkyl, hydroxy(C1-8 'alkyl. C1-4 alkoxy(Ci-g)alkyl, C1-4 alkoxyhalo- C1-8)alkyl, tri(C1-4)alkvlsilyl(Ci.6)alkyl, C1-4 alkylcarbonyl(C1-8)alkyl, C1-4 alkylcarbonyl- halo(C1-4)alkyl, phenyl(M)alkyl, C2-8 alkenyl. halo(C2-8)alkenyl, C2-8 alkynyl, C3-8 cycloalkyl optionally substituted with chloro, fluoro or methyl, C3.8 cycloalkyl(C1-4)alkyl, phenylamino. piperidino or morpholino, the phenyl ring of phenylalkyl or phenylamino being optionally substituted with one, two or three substituents selected from halo, C1-4 alkyl, halo(C1-4)alkyl, C1-4 alkoxy,and halo(C1-4)alkoxy; and R4 is H, C1-4 alkyl, haIo(C1-4)alkyl or amino, or T A R and R together foR"" a C3.7 alkylene or C3.7 alkenylene chain optionally substituted with methyl, or, together with the nitrogen atom to which they are attached, R and R foR"" a morpholine, thiomorpholine, thiomorpholine S-oxide or thiomorpholine S-dioxide ring or a piperazine or piperazine N-(C1-4)alkyl (especially //-methyl) ring, in which the morpholine or piperazine rings are optionally substituted with methyl. and R is H, C1-4 alkyl or amino, or R" and R together foR"" a C4-6 alkylene chain optionally substituted with methyl, or, together with the nitrogen atom to which they are attached. R and R foR"" a morpholine ring. 11. A process for preparing a compound of the general foR""ula (1) according to claim 1 wherein R is chloro or fluoro and R2 is NR3R4 and W, X, Y, Z, R1, R3 and R4 are as defined in claim 1, which comprises reacting an amine of the general foR""ula NR R with a compound of the general foR""ula (6) or (13) wherein W, X, Y, Z and R] are as defined in claim 1 and R7 is C1-4 alkyl, other than the compound of foR""ula (6) wherein X and Y are N, W and Z are C-Cl and R1 is CI. 13. A plant fungicidal composition comprising a fungicidally effective amount of a compound as defined in claim 1 and a suitable carrier or diluent therefor. 14. A method of combating or controlling phytopathogenic fungi which comprises applying to a plant, to a seed of a plant, to the loC1-4s of the plant or seed or to soil or to any other plant growth medium, a fungicidally effective amount of a compound according to claim 1 or a composition according to claim 13.

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