Title of Invention	A COMPOUND OF FORMULA I HAVING AN ACTIVITY TO INHIBIT MATRIX METALLOPROTEINASES
Abstract	Compounds having formula (I) are matric metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.

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THE PATENTS ACT, 1970 COMPLETE SPECIFICATION Section 10 "A Compound of Formula I haying an Activity to Inhibit Matrix Metalloproteinases" Abbott Laboratories, U.S.A. a corporation organized and existing under the laws of Illinois, of 100, Abbott Park Road, Abbott Park, Illinois 60064-6008, USA. GRANTED 9-8-2007 The following specification particularly describes the nature of this invention and the manner in which it is to be performed: ORIGINAL IN/PCT/2001/747/MUM (1) hydrogen, and (2) alkyl, or R3 and R4 taken together are oxo, or R3 and R4 , taken together with the carbon atom to which they are attached, form a cycloalkyl ring; R5 and R6 are independently selected from the group consisting of (l)hydrogen, (2) alkyl, (3) perfmoroalkyl, (4) halo, (5) haloalkyl, (6) alkoxy, (7) hydroxy, (8) hydroxyalkyl, (9) alkoxyalkyl, and (10) nitro; Y is selected from the group consisting of (l)acovalentbond, (2)-O-, (3) alkylene of two to four carbon atoms, (4) piperidineneyl, (5) alkenylene of two carbon atoms, (6) alkynylene of two carbon atoms, (7)-S02-, and (8)-C(0)-; Ar is selected from the group consisting of (1) phenyl, (2) pyridyl, Technical Field This invention relates to compounds having activity to inhibit matrix metalloproteinases, to pharmaceutical compositions comprising these compounds, and to a medical method of treatment. More particularly, this invention concerns reverse hydroxamate-containing compounds which inhibit matrix metalloproteinases, pharmaceutical compositions comprising the compounds, and methods of inhibiting matrix metalloproteinases in a mammal. Background of the Invention The matrix metalloproteinases (MMP's) are a class of extracellular enzymes including collagenase, stromelysin, and gelatinase which are believed to be involved in the tissue destruction which accompanies a large number of disease states varying from arthritis to cancer. Typical connective tissue cells are embedded within an extracellular matrix of high molecular weight proteins and glycoproteins. In healthy tissue, there is a continual and delicately-balanced series of processes which include cell division, matrix synthesis and matrix degradation. In certain pathological conditions, an imbalance of these three processes can lead to improper tissue restructuring. In arthritis, for example, joint mobility can be lost when there is improper remodeling of load-bearing joint cartilage. With cancer, lack of coordination of cell division and the two processes of matrix synthesis and degradation may lead to conversion of transformed cells to invasive phenotypes in which increased matrix turnover permits tumor cells to penetrate basement membranes surrounding capillaries which, in turn, may lead to subsequent metastasis. There has been heightened interest in discovering therapeutic agents which bind to and inhibit MMP's. The discovery of new therapeutic agents possessing this activity will lead to new drugs having a novel mechanism of action for combating disease states involving tissue degenerative processes including, for example, rheumatoid arthritis, osteoarthritis, osteopenias such as osteoporosis, periodontitis, gingivitis, corneal, epidermal or gastric ulceration, and tumor growth and metastasis or invasion. This invention discloses a series of MMP inhibitors having a unique combination of potency, pharmacokinetics, and fewer side effects. Summary of the Invention In its principle embodiment, the present invention provides a matrix metalloproteinase inhibitory compound of formula (I), or a pharmaceutical] y acceptable salt or prodrug thereof, wherein W is selected from the group consisting of (l)-O-, (2)-CH20-, and (3)-CH2s wherein each group is drawn with its left-hand end being the end which attaches to the carbon containing R1 and R2, and its right-hand end being the end which attaches to the carbon containing R and R ; X is selected from the group consisting of (l)-O-, and (2) -N(R7)-, wherein R7is selected from the group consisting of (a) hydrogen, (b) alkyl, (c) -S02-alkyl, and (d) alkanoyl; R1 and R2 are independently selected from the group consisting of (1) hydrogen, (2) alkyl, and (3) hydroxyalkyl; R3and R4 are independently selected from the group consisting of (3) pyrazinyl, (4) pyridazinyl, (5)furyl, (6) thienyl, (7) isoxazolyl, (8) oxazolyl, (9) thiazolyl, and (l0)isothiazolyl, wherein (1)-(10) can be optionally substituted with one, two, or three substituents independently selected from the group consisting of (a)alkyl, (b) alkoxy, wherein the alkoxy can be optionally substituted with alkoxy, (c) -(alkylene)-CC>2R8 , wherein R8 is either hydrogen or alkyl, (d) -(alkylene)-NR 9R10 , wherein R9 and R10 are independently selected from the group consisting of (i) alkyl, (ii) phenyl, and (iii) phenylalkyl, wherein for (ii) and (iii), the phenyl and the phenyl part of die phenylalkyl can be optionally substituted with one or two substituents independently selected from the group consisting of halo and alkoxy, (e) alkoxyalkyl, (f) cyano, (g) cyanoalkyl, (h)halo, (i) haloalkyl, (j) hydroxy, (k) hydroxyalkyl, (1) thioalkoxy, (m) thioalkoxyalkyl, (n) phenylalkoxy, (o) phenoxy, (p) phenoxyalkyl, (q) (heterocycle)oxy, (r) (heterocycle)oxyalkyl, (s) perfluoroalkyl, (t) perfluoroalkoxy, (u) sulfmylalkyl, (v) sulfonylalkyl, (w) , wherein A is selected from the group consisting of -CH2-, -CH2O- and -O-, and B is selected from the group consisting of -C(O)- and - R" is either hydrogen or alky], and v is 1-3, and (x) -N(R )S02R , wherein R11 is selected from the group consisting of (i) hydrogen, (ii) alkyl, and (iii) -N(R8 )(R 12 ), wherein R is hydrogen or alkyl, wherein for (q) and (r), the heterocycle part of the (heterocycle)oxy and the (heterocycle)oxyalkyl are selected from the group consisting of (i) pyridyl, (ii) pyrazinyl, (iii) pyridazinyl, (iv) furyl, (v) thienyl, (vi) isoxazolyl, (vii) oxazolyl, (viii) thiazoloyl, and (ix) isothiazolyl, and wherein for (q) and (r), the heterocycle part of the (heterocycle)oxy and the (heterocycle)oxyaIkyl can be optionally substituted with one or two substituents independently selected from the group consisting of (i) alkyl, (ii) alkoxy, (iii) perfluoroalkyl, (iv) halo, (v) cyano, (vi) cyanoalkyl, (vii) haloalkyl, and (viii) alkanoyl, and wherein for (o) and (p), the phenyl pan of the phenoxy and the phenoxyalkyl can be optionally substituted with one or two substituents independently selected from the group consisting of (i)alkyl, (ii) alkoxy, (iii) perfluoroalkyl, (iv) halo, (v) cyano, (vi) cyanoalkyl, (vii) haloalkyl, and (viii) alkanoyl. Preferred compounds of the invention are those wherein both X and W of formula I are oxygen. In another embodiment, the present invention provides pharmaceutical compositions which comprise a therapeutically effective amount of compound of formula I in combination with a pharmaceuticaly acceptable carrier. In yet another embodiment, the present invention provides a method of inhibiting matrix metalloproteinases in a mammal in recognized need of such treatment comprising administering to the mammal a therapeutically effective amount of a compound of formula I. Detailed Description of the Invention As used throughout this specification and the appended claims, the following terms have the meanings specified: The term "alkanoyl," as used herein, represents an alkyl group attached to the parent molecular moiety through a carbonyl group. The term "alkenylene," as used herein, represents a divalent group derived from a straight or branched chain hydrocarbon containing at least one double bond. The term "alkoxy," as used herein, represents an alkyl group attached to the parent molecular moiety through an oxygen atom. The alkoxy groups of this invention can be optionally substituted. The term "alkoxyalkyl," as used herein, represents an alkoxy group attached to the parent molecular moiety through an alkylene group. The term "alkyl," as used herein, represents a saturated straight or branched chain hydrocarbon radical. The term "alkylene," as used herein, represents a saturated divalent hydrocarbon group derived from a straight or branched chain saturated hydrocarbon by the removal of two hydrogen atoms. The term "alkynylene," as used herein, represents a divalent group derived from a straight or branched chain hydrocarbon containing at least one triple bond. The term "cyano," as used herein, represents -CN. The term "cyanoalkyl," as used herein, represents a cyano group attached to the parent molecular moiety through an alkyl group. The term "halo," as used herein, represents -F, -C1, -Br, and -I. The term "haloalkyl," as used herein, represents an alkyl group substituted by one, two, three, or four halogen atoms. The term "heterocycle," as used herein, represents a five-, six-, or seven-membered ring containing one, two, or three heteroatoms independently selected from the group consisting of nitrogen, oxygen, and sulfur. The five-membered ring has zero to two double bonds and the six- and seven-membered rings have zero to three double bonds. The heterocycle groups of this invention can be optionally substituted. The term "(heterocycle)oxy," as used herein, represents a heterocycle group attached to the parent molecular moiety through an oxygen atom. The (heterocycle)oxy groups of this invention can be optionally substituted. The term "(heterocycle)oxyalkyl," as used herein, represents a (heterocycle)oxy group attached to the parent molecular moiety through an alkyl group. The (heterocycle)oxyalkyl groups of this invention can be optionally substituted. The term "hydroxy," as used herein, represents -OH. The term "hydroxyalkyl," as used herein, represents a hydroxy group attached to the parent molecular moiety through an alkyl group. The term "nitro," as used herein, represents -NO2. The term "oxo," as used herein, represents (=0). The term "perfluoroalkoxy,' as used herein, represents a perfluoroalkyl group attached to the parent molecular moiety through an oxygen atom. The term "perfluoroalkyl," as used herein, represents an alkyl group wherein each hydrogen radical bound to the alkyl group has been replaced by a fluoride radical. The term "pharmaceutically acceptable prodrug," as used herein, represents those prodrugs of the compounds of the present invention which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of humans and lower animals with undue toxicity, irritation, allergic response, and the like, commensurate with a reasonable benefit/risk ratio, and effective for their intended use, as well as the zwitterionic forms, where possible, of the compounds of this invention. The term "pharmaceutically acceptable salt," as used herein, represents salts which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of humans and lower animals without undue toxicity, irritation, allergic response and the like and are commensurate with a reasonable benefit/risk ratio. The salts can be prepared in situ during the final isolation and purification of the compounds of the invention or separately by reacting the free base group with a suitable organic acid. Representative acid addition salts include acetate, adipate, alginate, ascorbate, aspartate, benzenesulfonate, benzoate, bisulfate, borate, butyrate, camphorate, camphersulfonate, citrate, cyclopentanepropionate, digluconate, dodecylsulfate, ethanesulfonate, fumarate, glucoheptonate, glycerophosphate, hemisulfate, heptonate, hexanoate, hydrobromide, hydrochloride, hydroiodide, 2-hydroxy-ethanesulfonate, lactobionate, lactate, laurate, lauryl sulfate, malate, maleate, malonate, methanesulfonate, 2-naphthalenesulfonate, nicotinate, nitrate, oleate, oxalate, palmitate, pamoate, pectinate, persulfate, 3-phenylpropionate, phosphate, picrate, pivalate, propionate, stearate, succinate, sulfate, tartrate, thiocyanate, toluenesulfonate, trifluoroacetate, undecanoate, valerate salts and the like. Representative alkali or alkaline earth metal salts include sodium, lithium, potassium, calcium, magnesium and the like, as well as nontoxic ammonium, quaternary ammonium, and amine cations, including, but not limited to ammonium, tetramethylammonium, tetraethylammonium, methylamine, dimethylamine, trimethylamine, triethylamine, ethylamine and the like. The term "phenoxy," as used herein, represents a phenyl group attached to the parent molecular moiety through an oxygen atom. The phenoxy groups of this invention can be optionally substituted. The term "phenoxyalkyl," as used herein, represents a phenoxy goup attached to the parent molecular moiety through an alkyl group. The phenoxyalkyl groups of this invention are optionally substituted. The term "phenylalkoxy," as used herein, represents a phenyl group attached to the parent molecular moiety through an alkoxy group. The term "phenylalkyl," as used herein, represents a phenyl group attached to the parent molecular moiety through an alkyl group. The phenylalkyl groups of this invention can be optionally substituted. The term "prodrug," as used herein, represents compounds which are rapidly transformed in vivo to parent compounds defined above, such as, by hydrolysis in blood. The term "sulfinyl," as used herein, represents -S(O)-. The term "sulfinylalkyl," as used herein, represents an alkyl group attached to the parent molecular moiety through a sulfinyl group. The term "sulfonyl," as used herein, represents -SO,-. The term "sulfonylalkyl," as used herein, represents an alkyl group attached to the parent molecular moiety through a sulfonyl group. The term "thioalkoxy," as used herein, represents an alkyl group attached to the parent molecular moiety through a sulfur atom. The term "thioalkoxyalkyl," as used herein, represents a thioalkoxy group attached to the parent molecular moiety through an alkyl group. Compounds of the present invention can exist as stereoisomers, wherein asymmetric or chiral centers are present These compounds are designated by the symbols "R" or "S," depending on the configuration of substituents around the chiral carbon atom. The present invention contemplates various stereoisomers and mixtues thereof. Stereoisomers include eriantiomers and diastereomers, and mixtures of enantiomers or diastereomers are designated (RS). Individual stereoisomers of compounds of the present invention may be prepared synthetically from commercially available starting materials which contain asymmetric or chiral centers or by preparation of racemic mixtures followed by resolution well-known to those of ordinary skill in the art. These methods of resolution are exemplified by (1) attachment of a mixture of enantiomers to a chiral auxiliary, separation of the resulting mixture of diastereomers by recrystallization or chromatography and liberation of the optically pure product from the auxiliary or (2) direct separation of the mixture of optical enantiomers on chiral chromatographic columns. In accordance with methods of treatment and pharmaceutical compositions of the invention, the compounds can be administered alone or in combination with other matrix metalloproteinase inhibiting agents. When using the compounds, the specific therapeutically effective dose level for any particular patient will depend upon factors such as the disorder being treated and the severity of the disorder, the activity of the particular compound used; the specific composition employed; the age, body weight, general health, sex, and diet of the patient; the time of administration; the route of administration; the rate of excretion of the compound employed; the duration of treatment; and drugs used in combination with or coincidently with the compound used. The compounds can be administered orally, parenterally, osmotically (nasal sprays), rectally, vaginally, or topically in unit dosage formulations containing carriers, adjuvants, diluents, vehicles, or combinations thereof. The term "parenteral" includes infusion as well as subcutaneous, intravenous, intramuscular, and intrastemal injection. Parenterally adminstered aqueous or oleaginous suspensions of the compounds can be formulated with dispersing, wetting, or suspending agents. The injectable preparation can also be an injectable solution or suspension in a diluent or solvent. Among the acceptable diluents or solvents employed are water, saline, Ringer's solution.buffers, monoglycerides, diglycerides, fatty acids such as oleic acid, and fixed oils such as monoglycerides or diglycerides. The inhibitory effect of parenterally administered compounds can be prolonged by slowing their absorption. One way to slow the absorption of a particular compound is adminstering injectable depot forms comprising suspensions of crystalline, amorphous, or otherwise water-insoluble forms of the compound. The rate of absorption of the compound is dependent on its rate of dissolution which is, in turn, dependent on its physical state. Another way to slow absorption of a particular compound is administering injectable depot forms comprising the compound as an oleaginous solution or suspension. Yet another way to slow absorption of a particular compound is administering injectable depot forms comprising microcapsule matrices of the compound trapped within liposomes, microemulsions, or biodegradable polymers such as polylactide-polyglycolide, polyorthoesters or polyanhydrides. Depending on the ratio of drug to polymer and the composition of the polymer, the rate of drug release can be controlled. Transdermal patches can also provide controlled delivery of the compounds. The rate of absorption can be slowed by using rate controlling membranes or by trapping the compound within a polymer matrix or gel. Conversely, absorption enhancers can be used to increase absorption. Solid dosage forms for oral administration include capsules, tablets, pills, powders, and granules. In these solid dosage forms, the active compound can optionally comprise diluents such as sucrose, lactose, starch, talc, silicic acid, aluminum hydroxide, calcium silicates, polyamide powder, tableting lubricants, and tableting aids such as magnesium stearate or microcrystalline cellulose. Capsules, tablets and pills can also comprise buffering agents, and tablets and pills can be prepared with enteric coatings or other release-controlling coatings. Powders and sprays can also contain excipients such as talc, silicic acid, aluminum hydroxide, calcium silicate, polyamide powder, or mixtures thereof. Sprays can additionally contain customary propellants such as chlorofluorohydrocarbons or substitutes therefor. Liquid dosage forms for oral administration include emulsions, microemulsions, solutions, suspensions, syrups, and elixirs comprising inert diluents such as water. These compositions can also comprise adjuvants such as wetting, emulsifying, suspending, sweetening, flavoring, and perfuming agents. Topical dosage forms include ointments, pastes, creams, lotions, gels, powders, solutions, sprays, mhatents, and transdermal patches. The compotmu is mixed, troder sterile conditions with a carrier and any needed preservatives or buffers. These dosage fofms can also include excipients such as animal and vegetable fats, oils, waxes, paraffins, starch, tragacanth, cellulose derivatives, polyethylene glycols, silicones, bentonites, silicic acid, talc and zinc oxide, or mixtures thereof. Suppositories for rectal or vaginal administration can be prepared by mixing the compounds with a suitable nonirritating excipient such as cocoa butter or polyethylene glycol each of which is solid at ordinary temperature but fluid in the rectum or vagina. Ophthalmic formulations comprising eye drops, eye ointments, powders, and solutions are also contemplated as being within the scope of this invention. The total daily dose of the compounds administered to a host in single or divided doses can be in amounts from about 0.1 to about 200 mg/kg body weight or preferably from about 0.25 to about 100 mg/kg body weight. Single dose compositions can contain these amounts or submultiples thereof to make up the daily dose. Preferred compounds of the invention are those wherein both X and W of formula I are oxygen. Additional preferred embodiments are: compounds of formula (I), wherein R and R are hydrogen, compounds of formula (I), wherein Y is -O-, and compounds of formula (I), wherein Y is a covalent bond. Most preferred is the compound of Example 1 • Specific compounds of the instant invention include, but are not limited to, (l5)-l-((4S)-2,2-dimethyl-l,3-dioxolan-4-yl)-2-((4-(4-(trifluoromethoxy)phenoxy)phenyl)sulfonyl)ethyl(hydroxyXormamide, (lP)-l-((4S)-2,2-dimethyl-l,3-dioxolan-4-yI)-2-((4-(4-(trifluoromethoxy)phenoxy)phenyl)sulfonyl)ethyl(hydroxy)formamide, (lR)l-((4R)-2,2-dimethyl-l,3-dioxolan-4-yl)-2-((4-(4-(trifluoromemoxy)phenoxy)phenyl)sulfonyl)emyl(hydroxy)formamide, (lS)-(4R)-2,2-dimethyl-l,3-dioxolan-4-yl)-2-((4-(4-(trifluoromethoxy)phenoxy)phenyl)sulfonyl)ethyl(hydroxy)formamide, 4-chloro-4,-(((2S)2-((4S)2,2-dimethy]-l,3-dioxolan-4-yl)-2-(formyl(hydroxy)amino)ethyl)sulfonyl)-l,r-biphenyl, (lS)-l-((4S)-2,2-diethyl-l,3-dioxolan-4-yl)-2-((4-(4-(trifluoromethoxy)phenoxy)phenyl)sulfonyl)ethyl(hydroxy)formamide, 1,4,5-trideoxy-4-(formyl(hydroxy)amino)-2,3-0-( 1-methylethylidene)-5-((4-(4- (trifluoromethoxy)phenoxy)phenyl)suIfony])-D-xylitol, (lS)-l-((4S)-2,2-dimethyl-l,3-dioxolan-4-yl)-2-((4-(4- methoxyphenoxy)phenyl)sulfonyl)ethyI(hydroxy)formamide, (lS)-2-((4-(4-chlorophenoxy)phenyl)sulfonyl)-l-((4S)-2,2-dimethyl-l,3-dioxolan-4- yl)ethyl(hydroxy)formamide, (lS)-l-((4S)-2,2-dimethyl-l,3-dioxolan-4-yl)-2-((4-(4- (trifIuoromethyI)phenoxy)phenyl)sulfonyl)ethyI(hydroxyXormarnide, (lS)-l-((4S)-2,2-dimethy1-1,3-dioxolan-4-yl)-2-((4-(4- methylphenoxy)phenyl)sulfonyl)ethyl(hydroxy)fonnamide, 4-(((2S)-2-((4S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2- (fonnyl(hydroxy)amino)dimethyl)sulfonyl)-4,-'rif]uoromethyl)-l,l '-biphenyl, (lS)-l-((4S)-l,3-dioxolan-4-yl)-2-((4-(4- (trifluoromethoxy)phenoxy)phenyl)sulfonyl)ethyl(hydroxy)fonnamide, 4-(((2S)-2-((4S)-2,2-dimethyl-l,3-dioxoIan4-yl)-2- (fonnyl(hydroxy)amino)ethyl)sulfony])-4'-(2-methoxyethoxy)-1 .l'-biphenyl, (lS)-l-((4S)-2,2-dimethy]-l,3-dioxolan-4-yI)-2-((4-(4-(2- methoxyethoxy)phenoxy)phenyI)sulfonyl)ethyl(hiydroxy)forraainide, l,2,4-trideoxy-2-(formyl(hydroxy)amino)-4,4-dimethyl-3,5-0-(l-methylethylidene)-l-((4- (4-(trifluoromethoxy)phenoxy)phenyl)sulfonyI)-D-threo-pentitol, hydroxy((lS)-l-((2R)-tetrahydro-2-furanyI)-2-((4-(4- (trifluoromedioxy)phenoxy)pheiiyl)sulfonyl)ethyl)fonnamide, hydroxy((lR)-l-((2R)-tetrahydro-2-furanyl)-2-((4-(4- (trifluoromethoxy)phenoxy)phenyl)sulfonyl)ethylXonnamide, hydroxy((lS)-l-((2R)-l-(methylsulfonyl)pyrrolidinyl)-2-((4-(4- (trifluoromethoxy)phenoxy)phenyl)sulfonyl)ethyl)onnamide, hydroxy((lRS)-l-((4S)-2-oxo-l,3-oxa20lidin-4-yl)-2-((4-(4- (trifluoromethoxy)phenoxy)phenyl)sulfonyI)ethyl)ormamide, hydroxy((lRS)-l-((4S)-3-methyl-2-oxo-l,3-oxazolidin-4-yl)-2-((4-(4- (trifluoromethoxy)phenoxy)phenyl)sulfonyl)ethyl)onnamide, and l,2-dideoxy-2-(foraiyl(hydroxy)amino)-3,4-0-(l-methylethylidene)-l-((4-(4- (trifluoromethoxy)phenoxy)phenyl)sulfonyl)-L-threo-pentitol. A more preferred compound for the practice of the instant invention is (lS)-l-((4S)-2,2-dimethyl-l,3-dioxolan-4-yl)-2-((4-(4-(trifluoromethoxy)phenoxy)phenyl)sulfonyl)ethyl(hydroxy)formamide. Determination of Biological Activity The efficacy of the compounds of the invention as matrix metalloproteinase inhibitors was determined by measuring inhibition as outlined below for Gelatinase A, a member of this family of enzymes. Recombinant active gelatinase-A (MMP-2) is purchased from Oncogene Research. The enzyme is assayed by its cleavage of a fluorescent substrate in 15C volume in a microfluor plate as described in Science 1990, 247,954-958. Upon cleavage of the substrate, the fluorescence of the EDANS group is increased 30-fold, and this increase is monitored using a f-max (Molecular Devices) fluorescent plate reader (ex: 335 nm; em: 485 nm). The rates of cleavage of the substrate by gelatinase-A in the presence or absence of inhibitors are measured in a 40 min assay at ambient temperature. Stock solutions of the compounds in DMSO are prepared, and these solutions are diluted into the assay buffer (50 mM Tris HC1, pH 7.4, with 150 mM NaCl and 10 mM CaCb), which is also used for dilution of the enzyme and substrate. The potencies of the compounds [IC50], shown below in Table 1, are calculated by plotting the logit function of the percent inhibition data relative to control vs. the logarithm of the inhibitor concentrations. Synthetic Methods Abbreviations which have been used in the descriptions of the schemes and the examples that follow are: DMSO for dimethylsulfoxide; MTBE for methyl tert-butyl ether, THF for tetrahydrofuran, and DMF for N,N-dimethylfonnamide. The compounds and processes of the present invention will be better understood in connection with the following synthetic scheme which illustrates methods by which the compounds of the invention can be prepared. The compounds can be prepared by a variety of synthetic routes. Representative procedures are shown in Scheme 1. The groups R1 , R2 R3 , R4 , R5 , and R6 are defined above. It will be readily apparent to one of ordinary skill in the art that the compounds defined above can be synthesized by substitution of the appropriate reactants and agents in the syntheses shown below. Scheme 1 (1) (2) As shown in Scheme 1, compounds of formula (1) can be converted to compounds of formula (3) by treatment with base followed by condensation with compounds of formula (2). Representative bases include n-butyllithium, tert-butyllithium, lithium hexamethyldisilazide, and lithium diisopropylamide. Examples of solvents used in these reactions include THF, diethyl ether, toluene, hexanes, or mixtures thereof. The reaction temperature is about -100 °C to 30 °C and depends on the method chosen. Reaction times are typically 0.5 to 8 hours. In a preferred embodiment, compounds of formula (1) are treated with n-butyllithium in THF at -78 °C, then treated with compounds of formula (2) in THF at -78°C for 3 hours to provide compounds of formula (3). Compounds of formula (3) can be converted to compounds of formula (4) by treatment with a reducing agent. Representative reducing agents include sodium borohydride, diisobutylaluminum hydride, lithium tri-tert-butoxyaluminohydride, and sodium triacetoxyborohydride. Examples of solvents used in these reactions include toluene, hexanes, THF, ethanol, methanol, or mixtures thereof. The reaction temperature is about -78 °C to 60 °C, and depends on the method chosen. Reaction times are typically about 15 minutes to 12 hours. In a preferred embodiment, compounds of formula (3) are treated with sodium borohydride in ethanol at room temperature for 0.5 hours to provide compounds of formula (4). Conversion of compounds of formula (4) to compounds of formula (5) can be accomplished by treatment with an acylating agent in the presence of excess base. Representative acylating agents include methanesulfonyl chloride, p-toluenesulfonyl chloride, trifluoracetic anhydride, and benzenesulfonyl chloride. Examples of bases include triethylamine, diisopropylethylamine, and pyridine. Representative solvents used in these reactions include dichloromethane, carbon tetrachloride, chloroform, THF, and diethyl ether. The reaction temperature is about -40 °C to 100 °C, and depends on the method chosen. Reaction times are typically 0.5 to 24 hours. In a preferred embodiment, compounds of formula (4) are treated with methanesulfonyl chloride and excess triethylamine in dichloromethane at 0 °C for 15 minutes, then warmed to room temperature for 1 hour to provide compounds of formula (5). Compounds of formula (5) can be converted to compounds of formula (6) by treatment with hydroxylamine. Examples of solvents used in this reaction include THF, diethyl ether, water, dioxane, or mixtures thereof. The reaction temperature is about -78 °C to 30 °C and depends on the method chosen. Reaction times are typically 0.5 to 24 hours. In a preferred embodiment, compounds of formula (5) are treated with aqueous hydroxylamine in THF at -35 °C and warmed to 0 °C over 4 hours to provide compounds of formula (6). Conversion of compounds of formula (6) to compounds of formula (7) can be accomplished by treatment with 2,2,2-trifluoroethyl formate or formic acetic anhydride. Examples of solvents used in these reactions includes MTBE, diethyl ether, THF, dichloromethane, and dioxane. The reaction temperature is about 25 °C to 120 °C and depends on the method chosen. Reaction times are typically 2 to 36 hours. In a preferred embodiment, compounds of formula (6) are treated with 2,2,2-trifluorethyl formate in MTBE at reflux for 20 hours to provide compounds of formula (7). The instant invention will now be described in connection with certain preferred embodiments which are not intended to limit its scope. On the contrary, the instant invention covers all alternatives, modifications, and equivalents as can be included within the scope of the claims. Thus, the following examples, which include preferred embodiments, will illustrate the preferred practice of the instant invention, it being understood that the examples are for the purposes of illustration of certain preferred embodiments and are presented to provide what is believed to be the most useful and readily understood description of its procedures and conceptual aspects. Example 1 (lS)-l-(4S)-2.2-dimethvl-1.3-dioxolan-4-vlV2-f(4-(4- (trifluoromethoxvbhenoxy phenvI)sulfonvl)ethl)hydroxvlformamide Example 1A 4-(4'-trifluoromethoxvphenoxy)phenyl methvIsulfone A mixture of anhydrous potassium carbonate (159.0 g, 1.15 mol), 4-trifluoromethoxyphenol (150 mL, 1.16 mol), and 4-fluorophenyl methyl sulfone (200.0 g, 1.15 mol) in DMSO (1.5 L) was heated to 120 °C and stirred vigorously for 18 hours. The mixture was cooled to room temperature, filtered through a glass wool plug with MTBE, and concentrated. The concentrate was diluted with water (1 L), and cooled to 0 °C. The resulting precipitate was collected by filtration, washed with water, and dried under vacuum at 50 °C. Recrystallization from MTBE/hexanes provided the desired product, mp: 71.5-72 °C. Example 1B l-((4Ry2.2-dimethvI-1.3-dioxolan-4-vlV2-((4-(4-(trifluoromethoxv)phenoxv)phenvi)sulfonvl)ethanone A solution of 4-(4'-trifluoromethoxyphenoxy)phenyl methyl sulfone (36.6 g, 0.11 mol) in THF (600 mL) at -78 °C was treated with n-butyllithium (2.5M in hexanes, 48.0 mL, 0.12 mol) over 5 minutes and stirred for 1 hour. The solution was transferred by cannula to a -78 °C solution of methyl (4R)-2,2-dimethyl-l,3-dioxolane-4-carboxylate (19.6 g, 0.12 mol) in THF (400 mL) over 30 minutes, stirred for 3 hours, treated with 1M H2SO4 (75 mL), and warmed to 0 °C. The aqueous phase was extracted with MTBE (500 mL), and the combined organic phases were washed with water and brine, dried (NazS04), and filtered. The solution was passed through a pad of silica gel (100 g), the pad was washed with MTBE, and the resulting solution was concentrated to 1/5 the original volume, treated with hexanes (300 mL), and cooled to room temperature. The resulting precipitate was collected by filtration, washed with MTBE/hexanes, and dried to provide the desired product. Example 1C (trifluoromethoxv)phenoxvtphenvl)teulfonvl)ethenvl)-1.3-dioxolane A suspension of Example 1B (37.3 g, 81 mmol) in ethanol (250 mL) at room temperature was treated with sodium borohydride (1.40 g, 37 mmol), stirred for 30 minutes, treated dropwise with acetic acid (1 mL), and concentrated. The concentrate was partitioned between ethyl acetate and water, and the organic phase was washed sequentially with 1 M NaHC03, water, and brine, dried (Na2S04), and filtered. The solution was passed through a pad of silica gel (200 g) using 3:2/hexanes:ethyl acetate, concentrated, redissolved in CH2CI2 (250 mL), treated with triethylamine (31.1 mL, 222 mmol), cooled to 0 °C, and treated with methanesulfonyl chloride (8.0 mL, 103 mmol) over 40 minutes. The mixture was stirred for 15 minutes, warmed to room temperature, stirred for 1 hour, washed sequentially with water, 1MHC1, water, 1M NaHC03, water, and brine, dried (Na2SO4), and filtered. The concentrate was purified by flash column chromatography on silica gel using 98:2/dichloromethane:ethyl, acetate. The purified concentrate was recrystallized from MTBE/hexanes to provide the desired product as a mixture of cis- and trans-isomers. mp: 67-71 °C. Examples ID and IE (trifluoromethoxv)phenoxv)phenvl)suIfonvl)ethvl)-2.2-dimethyI-l,3-dioxolane and (trifluoromethoxv)phenoxv)phenvl)sulfonyl)ethyl)-2,2-dimethvl-1.3'dioxolane A solution of Example 1C (28.6 g, 64.3 mmol) in THF (800 mL) at -35 °C was treated with 50% aqueous hydroxylamine (6.4 g, 193 mmol), warmed to 0 °C over 4 hours, and concentrated. The concentrate was dissolved in MTBE, washed with water and brine, dried (Na2S04), filtered, and concentrated. The concentrate was recrystallized from MTBE/hexanes to provide a mixture of two diastereomers, which were separated by flash column chromatography on silica gel using 70:30/hexanes:ethyl acetate to provide the desired products. Example IF (lSVl-((4SV2.2-dimethvl-1.3-dioxolan-4-vn-2-((4-(4- (trifluoromethoxy)phenoxv)phenvl)sulfonvnethylmvdroxv)formamide A mixture of 2,2,2-trifluoroethanol (500 mL) and formic acid (95-97%, 1140 mL) at 75 °C was stirred for 16 hours, t,hen distilled (64-66 °C) to provide 2,2,2-trifluoroethyl formate (TFE-F reagent) as an 8.9M solution. 'H NMR (300 MHz, CDC13): 4.55 (q, 2H), 8.12 (s, 1H). A solution of Example ID (21.6 g, 45.2 mmol) in MTBE (200 mL) was treated with TFE-F reagent (8.9M, 50 mL, 443 mmol), heated to reflux, stirred for 20 hours, and slowly cooled to room temperature. The mixture was cooled to 0 °C, and the resulting precipitate was collected by filtration, washed with cold MTBE, and dried to provide the desired product. mp: 127.5-128.5 °C; + 4.85 ° (c 2.14, CH2C12); MS (APCI) m/z 506 (M+H)+; 'H NMR (300 MHz, DMSO-cfc): 5 1.20 (s, 1.2H), 1.23 (s, 1.8H), 1.26 (s, 1.2H), 1.30 (s, 1.8H), 3.32 (t, 0.6H, J=7.5 Hz), 3.59-3.76 (m, 2.1H), 3.92-4.15 (m, 3H), 4.57 (t, 0.4H, 1=8.4 Hz), 7.18-7.32 (m, 4H), 7.48 (d, 2H, J=9.6 Hz), 7.82 (s, 0.6H), 7.88 (d, 0.8H, J=9.6 Hz), 7.94 (d, 1.2H, J=9.6 Hz), 8.13 (s, 0.4H), 9.63 (s, 0.6H), 10*00 (s, 0.4 H); Anal. Calcd. for C, 49.90; H, 4.39; N, 2.77; S, 6.34. Found: C, 49.88; H, 4.24; N, 2.76; S, 6.43. Example 2 (1R )1 -((4S )-2.2-dimeth vl-1.3-dioxolan-4-vn-2-( (4-(4-(trifluoromethoxv)phenoxv)phenvl)sulfonv)ethvl(hvdroxv)fonnamide The desired product was prepared by substituting Example IE for Example ID in Example 1F. mp: 149-150°C; MS (ESI) m/z 506 (M+H)+; "HNMR : S 1.04 (s, 1.5H), 1.13 (s, 1.5H), 1.20 (s, 1.5H), 1.23 (s, 1.5H), 3.57-4.11 (m, 5.5H), 4.39 (t, 0.5H, J=9.80 Hz), 7.19-7.30 (m, 4H), 7.49 (d, 2H, J=8.70 Hz), 7.86-7.97 (m, 2.5H), 8.15 (s, 0.5H), 9.71 (bs, 0.5H), 10.20 (s, 0.5H); Anal. Calcd. for C21H22N08SF3: C, 49.90; H, 4.38; N, 2.77. Found: C, 49.90; H, 4.35; N, 2.52. 13 Example 3 (1R)l-((4RV2.2-dimethvl-1.3-dioxolan-4-vI)-2-((4-(4- (trifluoromethoxv)phenoxv)phenvl)sulfonvl)ethvl(hvdroxy)formamide Examples 3A and 3B (4R)-1-((4R)l-fhvdroxvamino)-2-((4-(4- (trifIuoromethoxy)phenoxv)phenvl)suIfonvnethvlV2.2-dimethvl-1,3-dioxolatie and (4S)-4-((lS)l-mvdroxvaminoV2-((4--(4-(trifluoromethoxy)phenoxv)phenvl)sulfonvnethvn-2.2-dimethvl-1.3-dioxolane The desired product was prepared by substituting methyl (4S>2,2-dimethyl-l,3-dioxolane-4-carboxylate for methyl (4R)-2,2-dimethyl-l,3-dioxolane-4-carboxylate in Examples 1A-1E. MS (ESI) m/z 506 (M+H)+; 'H NMR (300 MHz, DMSO-dfi): 5 1.21 (s, 1.5H), 1.23 (s, 1.5H), 1.26 (s, 1.5H), 1.30 (s, 1.5H), 3.3-3.4 (m, 1H), 3.60-3.75 (m, 2H), 3.9-4.1 (m, 2.5H), 4.5-4.6 (m, 0.5H), 7.2-7.3 (m, 4H), 7.48 (d, 2H, J=8.7 Hz), 7.81 (s, 0.5H), 7.85-7.95 (m, 2H), 8.13 (s, 0.5H), 9.63 (br s,0.5H), 10.0(brs,0.5H); Anal. Calcd. for C21H22F3N08S: C, 49.90; H, 4.38; N, 2.77. Found: C, 49.90; H, 4.51; N, 2.66. Example 3C (lR)-l-(f4RV2.2-dimethvl-1.3-dioxolan-4-vlV2-((4-(4-(trifluoromethoxv)phenoxv)phenvl)sulfonvl)ethvl(hvdroxy)formamide The desired product was prepared by substituting Example 3B for Example IE in Example 2. Example 4 (1S)-l-((4RV2.2-dimethvl-1.3-dioxolan-4-vn-2-((4-r4-(trifluoromethoxv)phenoxv)phenvl)sulfonvl)ethyl(hvdroxv¥ormamide The desired product was prepared by substituting Example 3A for Example ID in Example IF. MS (ESI) m/z 506 (M+H)+; 'H NMR (300 MHz, DMSO-d6): 1.05 (s, 1.5H), 1.14 (s, 1.5H), 1.20 (s, 1.5H), 1.23 (s, 1.5H), 3.3-3:4 (m, 1H), 3.5-4.1 (m, 4.5H), 4.3-4.4 (m, 0.5H), 7.2-7.3 (m, 4H), 7.48 (d, 2H), 7.8-8.0 (m, 2.5H), 8.15 (s, 0.5H), 9.68 (br s, 0.5H), 10.10 (br s, 0.5H). £0 Example 5 Example 5A 4'-chIorof 1.1 '-biphenvlV4-vl methyhulfone The desired product was prepared by substituting 4-chlorophenylboronic acid for 4-trifluoromethylphenylboronic acid in Example 12A. Example 5B The desired product was prepared by substituting Example 5A for 4-(4'-trifluoromethoxyphenoxyjphenyl methyl sulfone in Example 1. MS (ESI) m/z 440 (M+H)+; !H NMR (DMSO-dg): 5 1.20 (s, 1.5H), 1.22 (s, 1.5H), 1.26 (s, 1.5H), 2.30 (s, 1.5H), 3.32-3.40 (m, 1H), 3.62-3.78 (m, 2H), 3.93-4.15 (m, 2.5H), 4.64 (t, 0.5H, J=8.4 Hz), 7.58 (d, 2H, J=8.4 Hz), 7.77-7.83 (m, 2H), 7.89 (s, 0.5H), 7.93-8.02 (m, 4H), 8.13 (s, 0.5H), 9.62 (bs, 0.5H), 9.97 (bs, 0.5H); Anal. Calcd. for C20H22NO6SCI: C, 54.60; H, 5.04; N, 3.18. Found: C, 54.48; H, 5.30; N, 3.13. Example 6 (trifluoromethoxy)phenoxy)phenvl)suulfonvl)ethvl(hvdroxy)formamide Example 6A A solution of Example 1A (1.0 g, 3.0 mmol) in THF (50 mL) at -78 °C was treated with n-butyllithium (2.5M in hexanes, 1.3 mL, 3.3 mmol) and stirred for 1.5 hours. The solution was added by cannula to a -78 °C solution of (R)2,2-diethyl-l,3-dioxolane-4-carboxaldehyde (0.95 g, 6.0 mmol) (prepared according to the procedure described in Synthesis, 1992, p. 587) in THF (10 mL), stirred for 3 hours, treated with saturated NH4C1, and extracted with ethyl acetate. The combined extracts were washed with brine, dried (MgSO4), filtered, and concentrated. The concentrate was purified first by flash column chromatography on silica gel with 3:l/hexanes:ethyl acetate to 3:2/hexanes:ethyl acetate, then by HPLC with 3:2/hexanes:ethyl acetate to provide the desired product as a mixture of diasteieomers. Example 6B The desired product was prepared by substituting Example 6 A for Example IB in Example 1C (omitting the sodium borohydride reduction), then substituting the resulting product for Example 1C in Examples 1D and 1F. MS (ESI) m/z 534 (M+H)+; 1H NMR (300 MHz, DMSO-d6): 5 0.7-0.8 (m, 6H), 1.4-1.6 (m, 4H), 3.2-3.3 (m, 1H), 3.45-3.55 (m, 1H), 3.69 (dd, 1H, J=8.7,15.6 Hz), 3.95-4.15 (m, 2.5H), 4.5-4.6 (m, 0.5H), 7.2-7.3 (m, 4H), 7.47 (d, 2H, J=8.4 Hz), 7.81 (s, 0.5H), 7.85-7.95 (m, 2H), 8.14 (s, 0.5H), 9.66 (br s, 0.5H), 10.11 (br s, 0.5H); Anal. Calcd for C23H26NO8SF3: C, 51.77; H, 4.91; N, 2.62. Found: C, 51.98; H, 5.12; N, 2.63. The desired product was prepared by substituting methyl 3,4-isopropylidene-L-threonate for methyl (R)-2,2-dimethyl-l,3-dioxolane-4-carboxylate in Example 1. MS (ESI) m/z 520 (M+H)+; 'H NMR (300 MHz, DMSO-d6): 6 1.2-1.3 (m, 9H), 3.3-3.5 (m, 2H), 3.6-3.9 (m, 3H), 4.1- 4.2 (apparent t, 0.5H, J=5.0 Hz), 4.6-4.7 (apparent t, 0.5H, J=5.0 Hz), 7.2-7.3 (m, 4H), 7.48 (d, 2H, J=9.0 Hz), 7.85-8.00 (m, 2.5H), 8.15 (s, 0.5H), 9.69 (s, 0.5H), 9.95 (s, 0.5H); Anal. Calcd. for C22H24NO8SF3: C, 50.86; H, 4.65; N, 2.69. Found: C, 51.01; H, 4.38; N, 2.47. The desired product was prepared by substituting 4-methoxyphenol for 4-trifluoromethoxyphenol in Example 1. 35 1H NMR (DMSO-d6): 5 1.20-1.32 (m, 6H), 3.24-3.35 (m, 1H), 3.58-3.70 (m, 2H), 3.78 (s, 3H), 3.92-4.13 (m, 2.5H), 4.57 (t, 0.5H, J=8.1 Hz), 7.00-7.14 (m, 6H), 7.84 (dd, 2H, J=12.3,2.1 Hz), 7.89 (s, 0.5H), 8.13 (s, 0.5H), 9.64 (s, 0.5H), 10.02 (s, 0.5H); Anal. Calcd. for C21H25N08S: C, 55.87; H, 5.58; N, 3.10. Found: C, 55.72; H, 5.59; N, 2.96. The desired product was prepared by substituting 4-chlorophenol for 4-trifluoromethoxyphenol in Example 1. mp: 157-158 °C; -f-2.2°(c 0.4, CH3OH); MS (ESI) m/z 456 (M+H)+; 'H NMR (DMSO-d6): 1.19-1.33 (m, 6H), 3.28-3.36 (m, 1H), 3.50-3.72 (m, 2H), 3.92-4.13 (m, 2.5H), 4.55 (t, 0.5H, J=8.1 Hz), 7.15-7.24 (m, 4H), 7.49-7.56 (m, 2H), 7.81 (s, 0.5H), 7.90 (t, 2H, J=9.3 Hz), 8.12 (s, 0.5H), 9.62 (s, 0.5H), 10.03 (s, 0.5H); Anal. Calcd. for C20H22NO7SCI: C, 52.69; H, 4.86; N, 3.07. Found: C, 52.67; H, 4.79; N, 2.87. 1 The desired product was prepared by substituting 4-trifluoromethylphenol for 4-trifluoromethoxyphenol in Example 1. mp: 141-143 °C; (a)D+2.0°(c 0.1, CH3OH); MS (APCI) m/z 490 (M+H)+; 'HNMR (DMSO-d6): 8 1.20-1.33 (m, 6H), 3.35-3.41 (m, 1H), 3.62-3.77 (m, 2H), 3.95-4.15 (m, 2.5H), 4.57 (t, 0.5H, J=8 Hz), 7.27-7.35 (m, 4H), 7.77-7.85 (m, 2.5H), 7.91-7.99 (m, 2H), 8.13 (s, 0.5H), 9.50-9.85 (m, 1H); Anal. Calcd. for C21H22F3NO7S: C, 51.53; H, 4.53; N, 2.86 Found: C, 51.60; H, 4.61; N, 2.88. The desired product was prepared by substituting 4-methylphenol for 4-trifluoromethoxyphenol in Example 1. mp: 156-158 °C; (x)D+5.0°(c 0.2, CH3OH); MS (APCI) m/z 436 (M+H)+; lH NMR (DMSO-dfi): 5 1.17-1.36 (m, 6H), 3.21-3.31 (m, 1H), 3.34 (s, 3H), 3.58-3.73 (m, 2H), 3.91-4.16 (m, 2.5H), 4.57-4.64 (m, 0.5H), 6.97-7.06 (m, 2H), 7.10 (d, 2H, J=9 Hz), 7.26 (d, 2H, J=9 Hz), 7.78-7.93 (m, 2.5H), 8.13 (s, 0.5H), 9.41-10.12 (bs, 1H); Anal. Calcd. for C21H25NO7S: C, 57.92; H, 5.79; N, 3.22;S,7.36. Found: C.57.63; H, 5.81; N, 3.11;S,7.21. A solution of 4-(trifluoromethyl)phenylboronic acid (12.0g, 62 mmol) and 4-bromophenyl methyl sulfone (14.93g, 62 mmol) in DMF (200 mL) was treated with Cs2C03 (61g, 187 mmol) and PdCl2(dppf)2 (1.5g), heated to 60 °C, stirred for 3 hours, cooled to room temperature, and stirred for 16 hours. The mixture was partitioned between ethyl acetate and water and the organic phase was washed sequentially with l:l/brine:water and brine, dried (Na2SO4), filtered, and concentrated. The concentrate was recrystallized from ethyl acetate/hexanes to provide the desired product. MS (APCI) m/z 318 (M+NH4)+ The desired product was prepared by substituting Example 12A for Example 1A in Examples 1B-1F. mp: 204-205 °C; (x)D+6.0°(c 0.1, CH3OH); MS (ESI) m/z 474 (M+H)+; >H NMR (DMSO-de): 5 1.13-1.42 (m, 6H), 3.35-3.48 (m, 1H), 3.62-3.85 (m, 2H), 3.93-4.24 (m, 2.5H), 4.61-4.76 (m, 0.5H), 7.79-8.27 (m, 9H), 9.79-10.20 (m, 1H); Anal. Calcd. for C2,H22F3N06S: C, 53.27; H, 4.68; N, 2.96; S, 6.77; F, 12.04. Found: C, 53.09; H, 4.74; N, 2.89; S, 6.79; F, 12.21. Example 13 A solution of Example 1C (760 mg, 0.95 mmol) in THF (15mL) was treated with 3N HC1 (3 mL), heated to 45 °C, stirred for 1.5 hours, cooled to room temperature, and extracted with diethyl ether. The combined extracts were washed with brine, dried (Na2S04), filtered and concentrated to provide the desired product. MS(DCI) m/z 422 (M+NH4)+. A solution of Example 13 A (970 mg) in DMSO (12 mL) at 65 °C was treated with POCb, stirred for 2.5 hours, and partitioned between diethyl ether and water. The organic phase was washed with brine, dried (Na2S04), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel using 9:l/dichlorornethane:hexanes, then dichloromethane, then 9:l/dichloromethane:ethyl acetate to provide the desired product. MS(DCI) m/z 434 (M+NH4)+. The desired product was prepared by substituting Example. 13B for Example IB in Examples 1D and 1F. MS (ESI) m/z 476 (M-HV; 1H NMR (DMSO-de): 6 3.53-4.16 (m, 5.5H), 4.51-4.63 (m, 0.5H), 4.74 (d, 1H, J=12 Hz), 4.84 (s, 0.5H), 4.95 (s, 0.5H), 7.23 (d, 2H, J=9 Hz), 7.28 (d, 2H, J=9 Hz), 7.48 (d, 2H, J=9 Hz), 7.83 (s, 0.5H), 7.94 (dd, 2H, J=9,8.8 Hz), 8.17 (s, 0.5H), 9.15 (s, 0.5H), 10.03 (s, 0.5H); Anal. Caicd. for C19H18NO8SF3. C, 47.80; H, 3.80; N, 2,93. Found: C, 47.55; H, 3.76; N, 2.82. Example 14 The desired product was prepared by substituting 4-(methyIsulfanyl)phenylboronic acid and l-bromo-4-(2-methoxyethoxy)benzene for 4-(trifluoromethyl)phenylboronic acid and 4-bromophenyl methyl sulfone, respectively, in Example 12A. A suspension of Example 14A (2.8g, 10.2 mmol) in 2:l/methanol:water (100 mL) at 0 °C was treated with NaHC03 (2.14g, 25.3 mmol) and oxone (15.7g, 25.3 mmol), stirred for 1 hour, warmed to room temperature, and stirred for 48 hours. The mixture was partitioned between water and dichloromethane and the aqueous phase was extracted with dichloromethane. The combined extracts were washed with brine, dried (Na2SO4), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with l:l/hexanes:ethyl acetate to provide the desired product. MS (ESI) m/z 307 (M+H)+. (formyl(hydroxv)amino)ethyl)sulfonvl)4'-(2-methoxyethoxy)-l.r;biphenyl The desired product was prepared by substituting Example 14B for Example 1A in Examples IB-ID and 1F. MS (ESI) m/z 478 (M-HT; 'H NMR (DMSO-do) .21 (d, 3H, J=9 Hz), 1.25-1.35 (m, 3H), 3.28-3.42 (m, 4H), 3.46- 3.57 (m, 1H), 3.10-3.26 (m, 3H), 3.86-4.20 (m, 4H), 4.29-4.45 (m, 0.5H), 4.57-4.68 (m, 0.5H), 7.08 (d, 2H, J=9 Hz), 7.68-7.77 (m, 2H), 7.83-7.97 (m, 4.5H), 8.14 (s, 0.5H), 9.62 (s, 0.5H), 9.98 (s, 0.5H); Anal. Calcd. for C23H29NO8S: C, 57.60; H, 6.09; N, 2.92. Found: C, 57.61; H, 6.10; N, 2.92. Example 15A l-(benzvioxv)-4-f2-methoxvethoxv)benzene A solution of 4-(benzyloxy)phenol (6.1g, 30.5 mmol), 2-methoxyethanol (2.4 mL, 30.5 mmol) and triphenylphosphine (8.78g, 30.5 mmol) in THF (150 mL) at 0 °C was treated with diethylazodicarboxylate (5.3 mL, 33.5 mmol), stirred for 10 minutes, warmed to room temperature, and stirred for 12 hours. The mixture was diluted with ethyl acetate, washed with 2N NaOH and brine, dried (Na2Sd4), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 9:l/hexanes:ethyl acetate to provide the desired product Example 15B 4-f2-methoxvethoxyVphenol A solution of Example 15A (4.8 g, 18.6 mmol) in methanol (48 mL) was treated with 20% Pd(OH)2 on carbon (0.48 g) and stirred under 60 psi of hydrogen at 50 °C for 1 hour. The mixture was filtered and the filtrate was concentrated to provide the desired product. MS (DCI) m/z 186 (M+NH4)+. Example 15C (lS)l-((4SV2.2-dimethvl-1.3-dioxolan-4-vl)2-((4-(4-(2-methoxvethoxv)phenoxv)phenvl)sulfonvl)ethvl(hvdroxy)formamide The desired product was prepared by substituting Example 15B for 4-trifluoromethoxyphenol in Example 1. 'H NMR (DMSO-de): 8 1.22 (d, 3H, J=9 Hz), 1.28 (d, 3H, J=12 Hz), 3.22-3.35 (m, 3H), 3.57-3.60 (m, 4H), 3.93-4.15 (m, 5.5H), 4.52-4.63 (m, 0.5H), 7.0-7.13 (m, 6H), 7.83 (d, 0.5H, J=3 Hz), 7.87 (d, 2H, J=10 Hz), 8.12 (s, 0.5H), 9.63 (s, 0.5H), 9.98 (s, 0.5H); Anal. Calcd. for C23H29O9SN: C, 55.74; H, 5.89; N, 2.82. Found: C, 55.65; H, 5.82; N, 2.79. Example 16 1,2.4-trideoxv-2-ffonnvlmvdroxy)aminoxy)-4.4-dimethyl)-3.5-0-(l-methylpthylidene)-l-((4-(4-(trifluoromethoxv)phenoxv)phenvl)sulfonvl)-D-threo-pentitol Example 16 A (3R)3-rrtert-butvl(dimethvl)siIvl)oxv)-5-hvdroxv-4.4-dimethvl-l-((4-(4- (trifluoromethoxy)phenoxy)phenyl)sulfonvl)-2-pentanone The desired product was prepared by substituting (3R)-3-((tert-butyl(dimethyl)silyl)oxy)-4.4-dimethyldihydro-2(3H)-furanone and memyl 4-(4-(trifluoromethoxy)phenoxy)phenyl sulfone for methyl (4R)-2,2-dimethyl-l,3-dioxolane-4-carboxylate and 4-(4'-trifluoromethoxyphenoxy)phenyl methyl sulfone, respectively, in Example 1B. A solution of Example 16A (1.7 g, 2.9 mmol) in THF (10 mL) at 0 °C was treated with tetrabutylammonium fluoride (1M in THF, 8.7 mL, 8.7 mmol), stirred for 1 hour, warmed to room temperature, stirred for 3 hours, and partitioned between ethyl acetate and brine. The organic phase was washed with brine, dried (MgSO4), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 65:35/hexanes:ethyl acetate to provide the desired product. A solution of Example 16B (l.lg, 2.4 mmol) and 2,2-propanediol (350 mL) in DMF (10 mL) at room temperature was treated with catalytic camphorsulfonic acid, stirred for 15 hours, and partitioned between water and ethyl acetate. The organic phase was washed with brine, dried (MgS04), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 3:l/hexanes:ethyl acetate to provide the desired product. The desired product was prepared by substituting Example 16C for Example IB in Examples 1C, 1D, and 1F. MS(ESI)m/z 546(M-H)"; 1H NMR (DMSO-de): 6 0.64-0.83 (m, 3H), 0.90 (s, 3H), 1.25-1.33 (m, 6H), 3.03-3.14 (m, 1H), 3.33-3.54 (m, 2H), 3.62-3.72 (m, 1H), 3.73-3.85 (m, 1H), 3.92-4.05 (m, 0.5H), 4.69-4.78 (m, 0.5H), 7.19-7.20 (m, 4H), 7.48 (d, 2H, J=9 Hz), 7.76 (s, 0.5H), 7.88-7.97 (m, 2H), 8.05 (s, 0.5H), 9.28 (s, 1H); Anal. Calcd. for C24H28N08SF3: C, 52.64; H, 5.15; N, 2.55. Found: C, 52.83; H, 5.30; N, 2.30. and The desired product was prepared by substituting methyl (2R)-tetrahydro-2-furancarboxylate for methyl (4R)-2,2-dimethyl-l,3-dioxolane-4-carboxylate in Examples 1A-1E. The desired product was prepared by substituting Example 17A for Example ID in Example 1F. mp: 121-122 °C; =-2.5° (c 1.08, CH3OH); MS (ESI, +Q1MS) m/z 476 (M+H)+; 'H NMR (500MHz, DMSO-d6): 8 1.37-1.45 (m, 1H), 1.71-1.82 (m, 2H), 1.88-1.99 (m, 1H), 3.28 (m, 0.6H), 3.56-3.73 (m, 4H), 3.81-3.91 (m, 2H), 4.46 (t, 0.4H, J=10.0 Hz), 7.22 (d, 2H, J=9.0 Hz), 7.25-7.29 (m, 2H), 7.46 (d, 2H, J=8.5 Hz), 7.77 (s, 0.6H), 7.90 (d, 2H, J=9.0 Hz), 7.93 (d, 2H, J=8.5 Hz), 8.12 (S, 0.4H), 9.45 (s, br, 0.6H), 9.82 (s, br, 0.4H); Anal. Calcd. for C20H20F3NO7S: C, 50.52; H, 4.24; N, 2.95. Found: C, 50.69; H, 4.47; N, 2.89. The desired product was prepared by substituting Example 17B for Example 1E in Example 2. mp: 142.5-143.5 °C; = -23.8° ( +2.0°(c 0.98, CH3OH); MS (ESI, +Q1MS) m/z 476 (M+H)+; 1H NMR (400MHz, DMSO-d6): 5 1.47-3.93 (m, 4H), 3.38-3.93 (m, 5.5H), 4.36 (t, 0.5H, J=8.8 Hz), 7.20-7.30 (m, 4H), 7.46 (d, 2H, J=8.88 Hz), 7.87-7.92 (m, 2.5H), 8.11 (s, 0.5H), 9.63 (s, br, 0.5H), 10.05 (s, br, 0.5H); Anal. Calcd. for: C20H20F3NO7S: C, 50.52; H, 4.24; N, 2.95. Found: C, 50.76; H, 4.34; N, 2.77. A 0 °C; solution of D-proline methyl ester hydrochloride (4.5g, 27mmol) (prepared according to the procedure described in Synthesis, 195,p. 772) in dichloromethane (2Qo mL) at room temperature was treated with triethylamine (11.3 mL, 81 mmol) and methylsulfonyl chloride (3.13 mL, 40 mmol), then stirred for 4 hours. The reaction wa.s partitioned between saturated NH4C1 and dichloromethane, and the organic phase was washed sequentially with saturated NaHCO3) and brine, dried (Na2S04), filtered, and concentrated \Q provide the desired product. MS (DCI) m/* 225 (M+NEUf. The d6,sired product was prepared by substituting Example 19A for methyl (R)-2,2-dimethyl-l,3-dioxolane-4-carboxylate in Example 1. MS (ESI) m/e 553 (M+H)+, 570 (M+NHt)+, 551 (M-H)'; (ά)D:-12.33°C, (CHC13, c 0.3); 'H NMR (30Q MHz, DMSO-d6): 5 1.65-1.78 (m, 3H), 1.93-2.08 (m, 1H), 2.85 (s, 0.4% 2.88 (s, 0.6H), 3.12-3.45 (m, 3H), 3.71-3.79 (m, 0.6H), 4.23-4.28 (m, 0.4H), 7.19-7.29 (m, 4H), 7.43-7.45 (d, 2H, J=8.7 Hz), 7.80 (s, 0.6H), 7.86-7.92 (m, 2H), 8.17 (s, 0.4H), 9.48 (s, 0.6H),9.71(s,o.4H). High resolution MS (FAB) Calc. m/z for (M+H)+ 553.0926, observed m/z 553.0930. The desired product was prepared as a mixture of diastereomers by substituting methyl (4R)-2-oxo-l,3-oxazolidine-4-carboxylate (prepared according to the procedure described in Tet. Lett. 1994, p. 2397) for methyl (R)-2,2-dimethyl-l,3-dioxolane-4-carboxylate in Example 1. MS (ESI +Q1MS) m/z 508 (M+NH4)+; lH NMR (400MHz, DMSO-de): 5 3.42-3.60 (m, 1H), 3.68-400 (m, 3H), 4.05-4.60 (m, 2H), 7.20-7.32 (m, 4H), 7.47 (d, 2H, J=6.6 Hz), 7.80-7.96 (M, 3.5H), 8.15 (S, 0.5H), 9.53 (S, br, 0.25H), 9.71 (S, br, 0.25H), 9.97 (s, br, 0.25H), 10.12 (s, br, 0.25H); Anal. Calcd. for C19H17F3OgS: C, 46.53; H, 3.49; N, 5.71. Found: C, 46.26; H, 3.43; N, 5.57. Example 21 hvdroxv((lRSyi-f(4SV3-methvl-2-oxo-1.3-oxazolidin-4-vlV2-f(4-(4-(trifluoromethoxy)phenoxv)phenvl)sulfonyl')ethvl¥ormamide The desired product was prepared as a mixture of diastereomers by substituting methyl (4R)-3-methyI-2-oxo-l,3-oxazolidine-4-carboxylate for methyl (R)-2,2-dimethyl-l,3-dioxolane-4-carboxylate in Example 1. MS (ESI, Q+1MS) m/z 505 (M+H)+, 522 (M+NH*)*; 'H NMR (400MHz, DMSO-d*): S 2.69 (s, 1.5H), 2.76 (s, 1.5H), 3.54-3.65 (m, IH), 3.79-3.94 (m, 2H), 4.21 (t, IH, J-8.8 Hz), 4.27-4.35 (m, IH), 4.49 (m, 0.5H), 4.89 (m, 0.5H), 7.22-7.32 (m, 4H), 7.47 (d, 2H), 7.90-7.98 (m, 2.5H), 8.17 (s, (X5H), 9.88 (s, br, 0.5H), 10.20 (s, br, 0.5H); Anal. Calcd. for CzoH^NaOgS: C, 47.62; H, 3.80; N, 5.55. Found: C, 47.95; H, 4.03; N, 5.34. Example 22 1.2-dideoxv-2-fformvlfhvdroxv')aminoV3.4-Q-( 1-methvlethvlideneV 1 -((4-(4-(trifluoromethoxv)phenoxv)phenvl)sulfonvl)-L-threo-pentitol The desired product was prepared by substituting (2S,3S)-2,3-0-isopropylidine-2,3,4-trihydroxybutanal tert-butyldimethylsilyl ether (prepared by the procedure described in J. Org. Chem. 1993,v. 58, p. 5153) for (R)-2,2-diethyl-l,3-dioxolane-4-carboxaldehyde in Example 6A, then substituting the resulting product for Example 6A in Example 6B and Example 16B. MS (ESI) m/z 536 (M+H)+, 553 (M+NHO*; 'H NMR (400 MHz, DMSO-d6): 5 9.96 (s, 0.5H), 9.62 (s, 0.5H), 8.14 (s, 0.5H), 7.94-7.88 (m, 2H), 7.81 (s, 0.5H), 7.48-7.45 (m, 2H), 7.29-7.20 (m, 4H), 5.18-5.12 (m, IH), 4.72-4.62 (m, IH), 4.10-3.92 (m, 2H), 3.80-3.62 (m, 2H), 3.60-3.30 (m, 4H), 1.29-1.22 (m, 6H). 3 It will be evident to one skilled in the art that the instant invention is not limited to the forgoing illustrative examples, and that it can be embodied in other specific forms without departing from the essential attributes thereof. It is therefore desired that the examples be considered in all respects as illustrative and not restrictive, reference being made to the appended claims, rather than to the foregoing examples, and all changes which come within die meaning and range of equivalency of the claims and therefore intended to be embraced therein. We claim: 1. A compound of formula (I) having an activity to inhibit matrix metalloproteinases, or a pharmaceutically acceptable salt or prodrug thereof, wherein W1 is selected from the group consisting of (1) -O-, (2) -CH2O-, and (3) -CH2-; wherein each group is drawn with its left-hand end being the end which attaches to the carbon containing R1 and R2, and its right-hand end being the end which attaches to the carbon containing R3 and R4 ; X is selected from the group consisting of (1) -O, and (2) -N(R7)-, wherein R7 is selected from the group consisting of (a) hydrogen, (b) alkyl, (c) -SCValkyl, and (d) alkanoyl; R1 and R2 are independently selected from the group consisting of (1) hydrogen, (2) alkyl, and (3) hydroxyalkyl; R3 and R4 are independently selected from the group consisting of (1) hydrogen, and (2) alkyl, or R3 and R4 taken together are oxo, or R3 and R4, taken together with the carbon atom to which they are attached, form a cycloalkyl ring; R5 and R6 are independently selected from the group consisting of (1) hydrogen, (2) alkyl, (3) perfluoroalkyl, (4) halo, (5) haloalkyl, (6) alkoxy, (7) hydroxy, (8) hydroxyalkyl, (9) alkoxyalkyl, and (10) nitro; Y1 is selected from the group consisting of (1) a covalent bond, (2) -O-, (3) alkylene of two to four carbon atoms, (4) piperidineneyl, (5) alkenylene of two carbon atoms, (6) alkynylene of two carbon atoms, (7) -SO2-, and (8) -C(O)-; Ar is selected from the group consisting of (1) phenyl, (2) pyridyl, (3) pyrazinyl, (4) pyridazinyl, (5) furyl, (6) thienyl, (7) isoxazolyl, (8) oxazolyl, (9) thiazolyl and (10) isothiazolyl, wherein (1)- (10) can be optionally substituted with one, two, or three substituents independently selected from the group consisting of (a) alkyl, (b) alkoxy, wherein the alkoxy can be optionally substituted with alkoxy, (c) -(alkylene)-CO2R8, wherein R8 is either hydrogen or alkyl, (d) -(alkylene)-NR9R10 wherein R9 and R10 are independently selected from the group consisting of (i) alkyl (ii) phenyl, and (iii) phenylalkyl, wherein for (ii) and (iii), the phenyl and the phenyl part of the phenylalkyl can be optionally substituted with one or two substituents independently selected from the group consisting of halo and alkoxy, (e) alkoxyalkyl, (f) cyano, (g) cyanoalkyl, (h) halo, (i) haloalkyl, (j) hydroxy, (k) hydroxyalkyl, (1) thioalkoxy, (m) thioalkoxyalkyl, (n) phenylalkoxy, (o) phenoxy, (p) phenoxyalkyl, (q) (heterocycle) oxy, (r) (r) (heterocycle) oxyalkyl, (s) perfluoroalkyl, (t) perfluoroalkoxy, (u) sulfinylalkyl, (v) sulfonylalkyl, {-A\ B (w) {-O/ wherein A is selected from the group consisting of -CH2-,-CH20-and -O-, and B is selected from the group consisting of-C (O)- and- (C (R") i)v, wherein R" is either hydrogen or alkyl and v is 1-3, and (x) -N(R8)S02Rn, wherein R11 is selected from the group consisting of (i) hydrogen, (ii) alkyl, and (iii) -N(R8) (R12), wherein R12 is hydrogen or alkyl, wherein for (q) and (r), the heterocycle part of (heterocycle) oxy, and (heterocycle) oxyalkyl are selected from the group consisting of (i) pyridyl, (ii) pyrazinyl, (iii) pyridazinyl, (iv) furyl, (v) thienyl, (vi) isoxazolyl, (vii) oxazolyl, (viii) thiazoloyl, and (ix) isothiazolyl, and wherein for (q) and (r), the heterocycle part of the (heterocycle) oxy and the (heterocycle) oxyalkyl can be optionally substituted with one or two substituents independently selected from the group consisting of (i) alkyl, (ii) alkoxy, (iii) perfluoroalkyl, (iv) halo, (v) cyano, (vi) cyanoalkyl, (vii) haloalkyl, and (viii) alkanoyl, and wherein for (o) and (p), the phenyl part of the phenoxy and the phenoxyalkyl can be optionally substituted with one or two substituents independently selected from the group consisting of (i) alkyl, (ii) alkoxy, (iii) perfluoroalkyl, (iv) halo, (v) cyano, (vi) cyanoalkyl, (vii) haloalkyl, and (viii) alkanoyl. 2. A compound of formula I as claimed in claim 1, wherein Ar is phenyl. 3. A compound of formula I as claimed in claim 2, wherein Y1 is -O-. 4. A compound of formula I as claimed in claim 3, wherein W1 is-O-. 5. A compound of formula I as claimed in claim 4, wherein X is-O-. 6. A compound of formula I as claimed in claim 5 selected from the group consisting of (1 S)-l- ((4S)-2,2-dimethyl-1, 3-dioxolan-4-yl)-2- ((4-(4-(trifluoromethoxy) phenoxy) phenyl) sulfonyl) ethyl (hydroxy) formamide, (lR)-l-((4S)-2,2-dimethyl-l, 3-dioxolan-4-yl)-2-((4-(4-(trifluoromethoxy) phenoxy) phenyl) sulfonyl) ethyl (hydroxy) formamide, (lR)-l-( (4R)-2,2-dimethyl-l, 3-dioxolan-4-yl)-2- ((4- (4-(trifluoromethoxy) phenoxy) phenyl) sulfonyl) ethyl (hydroxy) formamide, (lS)-l-((4R)-2,2-dimethyl-l, 3-dioxolan-4-yl)-2-((4-(4-(trifluoromethoxy) phenoxy) phenyl) sulfonyl) ethyl (hydroxy) formamide, (lS)-l-((4S)-2,2-diethyl-l, 3-dioxolan-4-yl)-2- ((4- (4-(trifluoromethoxy) phenoxy) phenyl) sulfonyl) ethyl (hydroxy) formamide, l,4,5-trideoxy-4-(formyl(hydroxy)amino)-2,3-0-(l-methylethylidene)-5- ( (4- (4- (trifluoromethoxy) phenoxy) phenyl) sulfonyl)-D-xylitol, (lS)-l-((4S)-2,2-dimethyl-l, 3-dioxolan-4-yl)-2- ((4- (4-methoxyphenoxy) phenyl) sulfonyl) ethyl (hydroxy) formamide, (lS)-2-((4-(4-chlorophenoxy) phenyl) sulfonyl)-l-((4S)-2, 2-dimethyl-l,3-dioxolan-4- yl) ethyl (hydroxy) formamide, (lS)-l-((4S)-2,2-dimethyl-l,3-dioxolan-4-yl)-2- ((4- (4-(trifluoromethyl) phenoxy) phenyl) sulfonyl) ethyl (hydroxy) formamide, (1S)-1- ((4S)-2,2-dimethyl-l, 3-dioxolan-4-yl)-2- ((4- (4-methylphenoxy) phenyl) sulfonyl) ethyl (hydroxy) formamide, (1S)-1-((4S)-1,3-dioxolan-4-yl)-2- ((4- (4- (trifluoromethoxy) phenoxy) phenyl) sulfonyl) ethyl (hydroxy) formamide, (lS)-l-((4S)-2,2-dimethyl-l, 3-dioxolan-4-yl)-2-((4-(4-(2-methoxyethoxy) phenoxy) phenyl) sulfonyl) ethyl (hydroxy) formamide, and l,2-dideoxy-2-(formyl (hydroxy) arnino)-3,4-0-(l-methylethylidene)-l-((4-(4-(trifluoromethoxy) phenoxy) phenyl) sulfonyl)-L-threo-pentitol. A compound of formula I as claimed in claim 4, wherein X is-N (R7)-. A compound of formula I as claimed in claim 7 selected from the group consisting of hydroxy((lRS)-l-((4S)-2-oxo-l, 3-oxazolidin-4- yl)-2-((4-(4-(trifluoromethoxy) phenoxy) phenyl) sulfonyl) ethyl) formamide and hydroxy((lRS)-l-((4S)-3-methyl-2-oxo-l, 3-oxazolidin-4-yl)-2-((4-(4- (trifluoromethoxy) phenoxy) phenyl) sulfonyl) ethyl) formamide. A compound of formula I as claimed in claim 3, wherein W1is -CH2-. A compound of formula I as claimed in claim 9 wherein X is -O-. A compound according to Claim 10 selected from the group consisting of hydroxy((lS)-l-((2R)-tetrahydro-2-furanyl)-2-((4-(4-(trifluoromethoxy) phenoxy) phenyl) sulfonyl) ethyl) formamide and hydroxy((lR)-l-((2R)-tetrahydro-2-furanyl)-2-((4-(4-(trifluoromethoxy) phenoxy) phenyl) sulfonyl) ethyl) formamide. A compound of formula I as claimed in claim 9, wherein X is-N (R7)-. A compound of formula I as claimed in claim 12 which is hydroxy ((lS)-l-((2R)-l-(methylsulfonyl)pyrrolidinyl)-2-((4-(4-(trifluoromethoxy) phenoxy) phenyl) sulfonyl) ethyl) formamide. A compound of formula I as claimed in claim 3, wherein W is-CH20-. 15. A compound of formula I as claimed in claim 14 which is l,2,4-trideoxy-2- (formyl (hydroxy) amino)-4,4-dimethyl-3,5-0- ( 1-methylethylidene)-l- ( (4-(4- (trifluoromethoxy) phenoxy) phenyl) sulfonyl)-D-threo-pentitol. 16. A compound of formula I as claimed in claim 2, wherein Y is a covalent bond, W1 is -O, and X is-O-. 17. A compound according to Claim 16 consisting of 4-chloro-4'-(((2S)-2- ((4S)-2,2-dimethyl-l,3-dioxolan-4-yl)-2-(formyl (hydroxy) amino) ethyl) sulfonyl)-l, l'-biphenyl, 4-(((2S)-2-((4S)-2,2-dimethyl-l,3-dioxolan-4-yl)-2- (formyl (hydroxy) amino) ethyl) sulfonyl)-4'-(trifluoromethyl)-l, l'-biphenyl, and 4- (((2S)-2-((4S)-2, 2-dimethyl-l,3-dioxolan-4-yl)-2-(formyl (hydroxy) amino) ethyl) sulfonyl)-4'- (2-methoxyethoxy)-l, l'-biphenyl. 18. A compound of formula I as claimed in claim 1, which is selected from the group consisting of (lS)-l-((4S)-2,2-dimethyl-l,3-dioxolan-4-yl)-2-((4-(4-(trifluoromethoxy)phenoxy)phenyl)sulfonyl)ethyl(hydroxy) formamide, (lR)-l-((4S)-2,2-dimethyl-l, 3-dioxolan-4-yl)-2- ((4-(4- (trifluoromethoxy) phenoxy) phenyl) sulfonyl) ethyl (hydroxy) formamide, (lR)-l-((4R)-2,2-dimethyl-l,3-dioxolan-4-yl)-2-((4-(4- (trifluoromethoxy) phenoxy) phenyl) sulfonyl) ethyl (hydroxy) formamide, (lS)-l-((4R)-2,2-dimethyl-l,3-dioxolan-4-yl)-2-((4-(4- (trifluoromethoxy) phenoxy) phenyl) sulfonyl) ethyl (hydroxy) formamide, 4-chloro-4'-(((2S)-2-((4S)-2,2-dimethyl-l,3-dioxolan-4-yl)-2- (formyl (hydroxy) amino) ethyl) sulfonyl)-!, l'-biphenyl, (lS)-l-((4S)-2,2-diethyl-l,3-dioxolan-4-yl)-2-((4-(4- (trifluoromethoxy) phenoxy) phenyl) sulfonyl) ethyl (hydroxy) formamide, l,4,5-trideoxy-4-(formyl(hydroxy)amino)-2,3-0-(l- methylethyhdene)-5-((4-(4-(trifluoromethoxy)phenoxy)phenyl) sulfonyl)-D-xylitol, (lS)-1-((4S)-2,2-dimethyl-l,3-dioxolan-4-yl)-2-((4-(4- methoxyphenoxy) phenyl) sulfonyl) ethyl (hydroxy) formamide, (lS)-2-((4-(4-chlorophenoxy) phenyl) sulfonyl)-l-((4S)-2/ 2-dimethyl- 1,3-dioxolan-4- yl) ethyl (hydroxy) formamide, (lS)-l-((4S)-2,2-dimethyl-l, 3-dioxolan-4-yl)-2- ((4-(4- (trifluoromethyl)phenoxy)phenyl)sulfonyl)ethyl(hydroxy) formamide, (lS)-l-((4S)-2,2-dimethyl-l, 3-dioxolan-4-yl)-2- ((4- (4- methylphenoxy) phenyl) sulfonyl) ethyl (hydroxy) formamide, 4-(({2S)-2-((4S)-2,2-dimethyl-l,3-dioxolan-4-yl)-2- (formyl (hydroxy) amino) ethyl) sulfonyl)'-rifluoromethyl)-1, 1'- biphenyl, (lS)-l-( (4S)-1,3-dioxolan-4-yl)-2- ((4- (4- (trifluoromethoxy) phenoxy) phenyl) sulfonyl) ethyl (hydroxy) formamide, 4-(((2S)-2-( (4S)-2,2-dimethyl-l,3-dioxolan-4-yl)-2- (formyl (hydroxy) amino) ethyl) sulfonyl)-4'- (2-methoxyethoxy)-L 1'-biphenyl, (lS)-l-((4S)-2,2-dimethyl-l,3-dioxolan-4-yl)-2-((4-(4-(2- methoxyethoxy) phenoxy) phenyl) sulfonyl) ethyl (hydroxy) formamide, l,2/4-trideoxy-2-(formyl(hydroxy)amino)-4,4-dimethyl-3,5-0-(l- methylethylidene)-l- ( (4--(4- (trifluoromethoxy) phenoxy) phenyl) sulfonyl)-D-threo-pentitol, hydroxy((lS)-l-((2R)-tetrahydro-2-furanyl)-2-((4-(4- (trifluoromethoxy) phenoxy) phenyl) sulfonyl) ethyl) formamide, hydroxy ((lR)-l-((2R)-tetrahydro-2-furanyl)-2-((4-(4- (trifluoromethoxy) phenoxy) phenyl) sulfonyl) ethyl) formamide, hydroxy ((lS)-l-((2R)-l-(methylsulfonyl) pyrrolidinyl)-2-((4-(4- (trifluoromethoxy) phenoxy) phenyl) sulfonyl) ethyl) formamide, hydroxy ((lRS)-l-((4S)-2-oxo-l, 3-oxazolidin-4-yl)-2-((4-(4-(trifluoromethoxy) phenoxy) phenyl) sulfonyl) ethyl) formamide, hydroxy((lRS)-l-((4S)-3-methyl-2-oxo-l,3-oxazolidin-4-yl)-2-((4-(4-(trifluoromethoxy) phenoxy) phenyl) sulfonyl) ethyl) formamide, and l,2-dideoxy-2- (formyl (hydroxy) amino)-3,4-0-(l-methylethylidene)-l-((4-(4- (trifluoromethoxy) phenoxy) phenyl) sulfonyl)-L-threo-pentitol. 19. The compound of formula I as claimed in claim 1 which is (lS)-l-((4S)-2,2-dimethyl-l, 3-dioxolan-4-yl)-2- ((4- (4-(trifluoromethoxy) phenoxy) phenyl) sulfonyl) ethyl (hydroxy) formamide. Dated this 21st day of June 2001. Archana Shanker of Anand And Anand Advocates Attorney for the Applicant

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