Indian Patents. 223690:A NOVEL 1,2,3 - TRIAZOLE DERIVATIVES OF FORMULA I

Title of Invention	A NOVEL 1,2,3 - TRIAZOLE DERIVATIVES OF FORMULA I
Abstract	The present invention relates to a novel compound of formula I wherein the substituents are as defined in the description; and to intermediates of formula II and Ilia useful in the preparation of compound of formula I. The present invention also encompasses a composition and a method for controlling microorganisms.

Full Text	The present invention relates to novel 1,2,3-triazole derivatives which have microbiocidal activity, in particular fungicidal activity. The invention also relates to novel intermediates used in the preparation of these compounds, to agrochemical compositions which comprise at least one of the novel compounds as active ingredient and to the use of the active ingredients or compositions in agriculture or horticulture for controlling or preventing infestation of plants by phytopathogenic microorganisms, preferably fungi. The present invention provides a compound of formula (I): (A22) Q is a single or a double bond; X is O, N(R1B), S or (CR19R20XCR2,R22)B1(CR2JRM)B: R1 is halogen, cyano, nitro, Cualkyl, CMhaloalkyl, CM alkoxy, CM haloalkoxy or optionally substituted CM alkenyl, optionally substituted CM alkynyl or optionally substituted S02(CM Jalkyl (where the optionally substituted moieties may each have up to 3 substituents, each independently selected from halogen and CM alkoxy); R2 is CM alkyl, CM haloalkyl, CM alkoxy(CM)alkyl or CMaUcylthio(CM)alk:yl or [optionally substituted aryl](CM)alkyl- or [optionally substituted aryl]oxy(CM)alkyl- (where the optionally substituted aryl moieties may each have up to 3 substituents, each independently selected from halogen and CM alkoxy); R3 is hydrogen, CH2C;€R4, CH2CR4=C(H)R\ CH=C=CHj or COR5 or optionally substituted CM alkyl, optionally substituted CM alkoxy or optionally substituted (CM) alkylC(=0)0 (where the optionally substituted moieties may each have up to 3 substituents, each independently selected from halogen, CM alkoxy, CM alkyl, C^ haloalkoxy, hydroxy, cyano, carboxyl, methoxycarbonyl, ethoxycarbonyl, methylsulfonyl and ethylsulfonyl); each R* is, independently, hydrogen, halogen, Chalky!, CMhaloalkyl, C\^a\koxyoiCi^alkoxy(Ci^)a\kyl; Rs is hydrogen or optionally substituted Cu alkyl, optionally substituted CM alkoxy, optionally substituted CM alkoxy(Ci^)alkyl, optionally substituted CM alkylthio(CM)alkyl or optionally substituted aryl (where the optionally substituted moieties may each have up to 3 substituents, each independently selected from halogen, Cj-g alkoxy, Ci-e haloalkoxy, cyano, hydroxy, methoxycarbonyl and ethoxycarbonyl); R6 is phenyl [optionally substituted by up to 3 substituents, each independently selected from halogen, cyano, nitro, CM alkyl, CM haloalkyl, CM alkoxy, CM haloalkoxy, CM haloalkylthio, C(H)=N-OH, C(H)=N-0(Ci.6 alkyl), C(Ci4 alkyl)=N-OH, C(CM alkyl)=N-0-(C,.6 alkyl), (Z)pCsCR25 and (Z)pCR28=CR26R27j, a 5-6 membered heterocyclic ring [in which tie ring contains 1 to 3 heteroatoms (each independently chosen from oxygen, sulphur and nitrogen) and the ring is optionally substituted by up to 3 substituents, each independently selected from halogen, cyano, nitro, CM alkyl, CM haloalkyl, CM alkoxy, CM haloalkoxy, C(HJ=N-0-(Ci-6 alkyl) and C(C,.6 alkyl)=N-0-(C,-6 alkyl)], C3.12 alkyl [optionally substituted by up to 6 substituents, each independently selected from halogen, cyano, CM alkoxy, CM thioalkyl, COO-CM alkyl, =N-OH, =N-0-(CM alkyl), C j.g cycloalkyl (itself optionally substituted by up to 3 substituents, each, independently selected from CM alkyl, halogen, CM alkoxy and CM haloalkoxy) and C4-g cycloalkenyl (itself optionally substituted by up to 3 substituents, each independently selected from CM alkyl, halogen, CM alkoxy and CM haloalkoxy)], C2-12 alkenyl [optionally substituted by up to 6 substituents, each independently selected from halogen, cyano, C\^ alkoxy, CM thioalkyl, COO-(CM alkyl), =N-OH, =N-0-(CM alkyl), C3.g cycloalkyl (itself optionally substituted by up to 3 substituents, each independently selected from CM alkyl, halogen, CMalkoxy and CM haloalkoxy) and C4.B cycloalkenyl (itself optionally substituted by up to 3 substituents, each independently selected from CM alkyl, halogen, CM alkoxy and C\^ haloalkoxy)], C202 alkynyl [optionally substituted by up to 6 substituents, each independently selected from halogen, cyano, CM alkoxy, CM thioalkyl, COO-CM alkyl, =N-OH, =N-0-(CM aikyl), C3.g cycloalkyl (itself optionally substituted by up to 3 substituents, each independently selected from CM alkyl, halogen, CM alkoxy and CM haloalkoxy), Si(CH3)3 and C4.B cycloalkenyl (itself optionally substituted by up to 3 substituents, each independently selected from CM alkyl, halogen, CM alkoxy and CM haloalkoxy)], C3.a cycloalkyl [optionally substituted by up to 3 substituents, each independently selected from halogen, CM alkyl, CM haloalkyl, CM alkoxy, CM haloalkoxy, CM thioalkyl, C3.6 cycloalkyl (itself optionally substituted by up to 3 substituents, each independently selected from CM alkyl, halogen, CM alkoxy and CM haloalkoxy) and phenyl (itself optionally substituted by up to five independently selected halogen atoms)], C4-6 cycloalkenyl [optionally substituted by up to 3 substituents, each independently selected from halogen, CM alkyl, CM haloalkyl, CM alkoxy, CM haloaucoxy, CM thioalkyl, C3.6 cycloalkyl (itself optionally substituted by up to 3 substituents, each independently selected from CM alkyl, halogen, CM alkoxy and CM haloalkoxy) and phenyl (itself optionally substituted by up to five independently selected halogen atoms)], C6.]2 bicycloalkyl [optionally substituted by up to 3 substituents, each independently selected from halogen. CM alkyl and CM haloalkyl] or an aliphatic, saturated or unsaturated group [in which the group contains three to thirteen carbon atoms and at least one silicon atom and, optionally, one to three heteroatoms, each independently selected from oxygen, nitrogen and sulphur, and the group is optionally substituted by up to four independently selected halogen atoms]; R7, Rs, R9, R10, R11 and R12 are each, independently, hydrogen, halogen, cyano, nitro, CM alkyl, CM haloalkyl, CM alkoxy, CM haloalkoxy, CM thioalkyl or CM thiohaloalkyl; R13, RM, RiS, R16 and R17 are each, independently, hydrogen, halogen, CM alkyl. C(0)CH3, CM haloalkyl, CM alkoxy, CM haloalkoxy, CM thioalkyl, CM thiohaloalkyl, hydroxymethyl or CM alkoxymethyl; RIS is hydrogen, CM alkyl, CM alkoxy(CM)aIkyl, formyl, C(=0)CM alkyl (optionally substituted by halogen or Ci-4-alkoxy) or C(=0)0-Cj^ alkyl (optionally substituted by halogen, CM alkoxy or CN); R19, R2°, R21, R22, R23 and R24 are each, independently, Ci-6 alkyl, CM alkenyl [both optionally substituted by halogen, hydroxy, =0, CM alkoxy, 0-C(0)-CM alkyl, aryl or a 3-7 rnembered carbocyclic ring (itself optionally substituted by up to three methyl groups)], a 3-7 rnembered carbocyclic ring (optionally substituted by up to three methyl groups and optionally containing one heteroatom selected from nitrogen and oxygen), hydrogen, halogen, hydroxy or CM alkoxy, or Rl9R20 together with the carbon atom to which they are attached form a carbonyl-group, a 3-5 rnembered carbocyclic ring (optionally substituted by up to three methyl groups), CM alkylidene (optionally substituted by up to three methyl groups) or C3-e cycloalkylidene (optionally substituted by up to three methyl groups); R25 is hydrogen, halogen, CM alkyl, CMhaloalkyl, CM alkoxy(Ci^)alkyl, CMhaloalkoxy{CM)alkyl or S1(CM alkyl)3; R26 and R27 are each, independently, hydrogen, halogen, CM alkyl or CM haloalkyl; R28 is hydrogen, CM alkyl or CM haloalkyl; mis 0 or l;n is 0 or 1; pis 0 or l;andZis CM alkylene. Halogen is fluoro, chloro, bromo or iodo. Each alkyl moiety is a straight or branched chain and is, for example, methyl, ethyl, n-propyl, n-butyl, H-pentyl, /i-hexyl, wo-propyl, sec-butyl, wo-butyl, tert-butyl, Heo-pentyi, H-heptyl, 1,3-dimethylbutyf, 1,3-dimethylpentyl, l-methyl-3-ethyl-butyl or 1,3,3-trimethylbutyl. Haloalkyl moieties are alkyl moieties which are substituted by one or more of the same or different halogen atoms and are, for example, CF3, CF2C1, CHF2, CH2F, CC13, CFjCH?, CHF2CH2, CH2FCH2, CH3CHF or CH3CF2. Alkenyl and alkynyl moieties can be in the form of straight or branched chains. The alkenyl moieties, where appropriate, can be of either the (E)- or (Z)-configuration. Examples are vinyl, allyl, ethynyl and propargyl. Alkylidene moieties can be in the form of straight or branched chains. Alkylidene includes methylidene [CH2=C], ethylidenc [CHjC(H)=C], u-propylidene, i-propylidene [(Cfb^OC], n-butylidene, /-butylidene, 2-butylidene, H-pentylidene, i-pentylidene, neo-pentylidene, 2-pentylidene, n-hexylidene, 2-hexylidene, 3-hexylidene, i-hexylidene and Jieo-hexylidene. Cycloalkyl includes cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl and cyclooctyl. Cycloalkenyl includes cyclobutenyl, cyciopentenyl, cyclohexenyl and cycloheptenyl Cycloalkylidene includes cyclopropylidene [c(CjH4)=C], cyclobutylidene, cyclopentylidene and cyclohexylidene. Bicycloalkyl includes bicyclo[l,l,l]pentyl, bicyc!o[2,l,l]hexyl, bicycIo[2,2,l]heptyl, bicyclo[2,2,2]octyl, bicyclo[3,2,l]octyl and bicyclo[3,2,2]nonyl. Aryl includes phenyl, naphthyl, anthracyl, fluorenyl and indanyl but is preferably phenyl. In one aspect of the invention, A is as defined above provided that it is not (Al). In another aspect of the invention, R6 is as defined above provided that it is not an aliphatic, saturated or unsaturated group [in which the group contains three to thirteen carbon atoms and at least one silicon atom and, optionally, one to three heteroatoms, each independently selected from oxygen, nitrogen and sulphur, and the group is optionally substituted by up to four independently selected halogen atoms]. In a further aspect of the invention, A is as defined above provided that it is not (Al) when R6 is an aliphatic, saturated or unsaturated group [in which the group contains three to thirteen carbon atoms and at least one silicon atom and, optionally, one to three heteroatoms, each independently selected from oxygen, nitrogen and sulphur, and the group is optionally substituted by up to four independently selected halogen atoms]. Preferably Q is a single bond. Preferably n is 0, Preferably m is 0. Preferably A is selected from formulae (Al), (A2), (A3), (A16), (A17), (A18), (AI9),(A20)and(A22). More preferably A is selected from formulae (Al), (A2), (A1S), (A19) and (A22). Even more preferably A is selected from one of the following ortho-substituted rings: Preferably X is O, NR18 or (CRl9R20)(CR21R22)m(CR23R24)„. MorepreferablyXisOorCCR'V^CR^R^WCR^R24^. Even more preferably X is (CR19R20)(CR2iR22)m(CR23R24)n. . Most preferably X is (CRI9R20). Preferably R1 is C, A alkyl, Cw haloalkyl, NOa, CN or OCF3. More preferably R! is CHF2, CF3, CH2F, CF2C1, CH3 or C2H5. Even more preferably R1 is CHF2, CF3, CH2F, CF2C1 or CH3. Most preferably R1 is CHF2, CF3 or CH2F. Preferably R2 is CM alkyl, CM haloalkyl, CM alkoxy(CM)alkyI or ClJ(alkylthio(C!.4)alkyl. More preferably R2 is CH3, CF3, C2Hi, CH2OCH3 or CH2SCH3. Even more preferably R2 is CH3 or C2Hs. Most preferably R2 is CH3. Preferably R3 is hydrogen, CH2C =CR4, CH2CR4=C(H)R4, CH=OCH2 or COR5. More preferably R3 is H, CH2C £H, CH=C=CH2, CH2CH=CH2 or COCH3. Still more preferably R3 is H, CH2CM:H, CH=C=CH2 or CH2CH=CH2. Even more preferably R3 is H, CH2C s€H or CH=C=CH2. Most preferably R3 is H. Preferably each R is, independently, H, halogen, Ci^alkylorCi-ialkoxy. More preferably each R4 is, independently, H, CI, Br, CH3 or CHjO. Still more preferably each R4 is, independently, H, CI or CH3, Most preferably each R4 is H. Preferably R3 is H, Ci.6 alkyl, CM alkoxy or CM alkoxy(CM)aIkyl. More preferably R5 is H, methyl, OC(CH3)3 or CH:OCH3. Even more preferably R5 is H or methyl. Preferably Rs is chosen from C3-i0 alkyl, C3.9 haloalkyl, C3-7 cycloalkyl [optionally substituted by C3 cycloalkyl (itself optionally substituted by C1-2 alkyl) or by up to two CM alkyl groups], an aliphatic group [which contains three to ten carbon atoms and at least one silicon atom and, optionally, one oxygen atom], thienyl [optionally substituted by halo], furyl [optionally substituted by halo], pyridyl [optionally substituted by halo], oxazolyl, isoxazolyl and where Rc and Rd are, independently, H, CI, Br, F, I, CN, N02, CM alkyl, CF3, SCF3, OCF3, CH=NOH, CH=N-OCu alkyl, C^CH, OC-Si(CH3)3, C(H)=CH2 or C(HKH(CH alkyl)- More preferably R6 is C3-7 alkyl, C3_e cycloalkyl [optionally substituted by CM alkyl or a C3 cycloalkyl (itself optionally substituted by C\.2 alkyl)], an aliphatic group (which contains three to eight carbon atoms and at least one silicon atom) or where Re is Ci, Br, F, CF3, OCF3, CH=N-OCM alkyl, C=CH, C=C-Si(CH3)3 or C(H)=CHj [in one aspect it is preferred that Rc is CI, Br, F, CF3, OCF3, CH=N-OC,.4 alkyl, CsCH or C(H)=CH2]. Even more preferably R is chosen from one of the following moieties: where Re is CI, Br, F, CF3, OCH, OC-Si(CH3)3 or CH=N-OCM alkyl [in one aspect it is preferred that Re is CI, Br, F, CF3, C^CH or CH=N-OCM alkyl]- Preferably R7 is H, F or CH3. Preferably R8 is H. Preferably R9 is H. Preferably R10 is H. Preferably R" is H. Preferably R12 is H. Preferably R13, Ru, R15, R1 are each, independently, H, CH3, C2HS, CF3, CH30, C(0)CH3 or CH3OCH2. More preferably R13, R14, R1S, R16 are each, independently, H or CH3. Preferably R17 is H. Preferably R18 is H, CH3, C2HS, C(0)OCi-4 alkyl (optionally substituted with halogen or CM alkoxy) or COH. More preferably R18 is C(0)OCM alkyl (optionally substituted with halogen or CM alkoxy) or COH, Even more preferably R18 is C(0)OCM alkyl (optionally substituted with halogen or CM alkoxy). Most preferably RIB is C(0)OCM alkyl. Preferably R19 and R2C are each, independently, H, halogen, Cu alkyl, d-3 alkoxy, CH20, C3.6 cycloalkyl, CH20-C(=0)CH3, CH2-C3-6 cycloalkyl or benzyl; or R19 and R20 together with the carbon atom to which they are attached form a carbonyl group, a 3-5 membered carbocyclic ring, Ci-s alkylidene or C3-6 cycloalkylidene. More preferably R19 and R20 are, independently, H, CH3, C2H5, H-C3H7,1-C3H7, 1-C+H9, CH(C2H5)2, CHrCyclopropyl or cyclopentyl; or R19 and R20 together with the carbon atom to which they are attached form a 3-membered caibocyclic ring. Preferably R21 is H or CH3. Preferably R22 is H or CH3. Preferably R23 is H or CH3. Preferably R24 is H or CH3. Compounds of formula (H): where R1 and R2 are as defined above for a compound of formula (I) and Y is halogen, hydroxy or Ci .5 alkoxy, are useful as intermediates in the preparation of compounds of formula (I). Some compounds of formula (II) are already known in the literature [B.Iddon et a!. J.Chem. Soc. PerkinTrans. 7,1341 (1996); M.Eegtrup etal., Acta Chemica Scand., 19, 2022 (1965); D.R.Buckie et al., J. Chem,Res, Syn. 10, 292 (1982); and A.Peratoner et al., ScLFis.Mat.Nal.Rend 5,16 (1907)] but others are novel. Therefore, in another aspect the present invention provides a compound of formula (H) where R1 and R2 are as defined above for a compound of formula (I) and Y is halogen, hydroxy or CJ.J alkoxy; provided that when R1 is chloro and R2 is 4-CH30-CsH4-CH3-, Y is not C:H50; when R1 is CH30 and R2 is CH3, Y is not C2H5O; when R1 is bromo and R2 is CH3OCH2, Y is not CH30; and when R1 is CH3 and R2 is C3H5, Y is not OH. Preferably Y is hydroxy, chloro, fluoro orQ.3 alkoxy. Some compounds of formula (ffla) are also novel but some are described in the literature [see, for example, L. A Paquette et al., J. Amer. Chem Soc. 99, 3734 (1977); H. Plieninger et al., Chem. Ber. 109, 2121 (1976); Kasansski et al., Zh. Obshch.Khim. (1959), 29, 2588; and A. J. Kirby et al., J. Chem. Soc, Perkin Trans. 2, 1997, 1081]. Anilines of formula (Ilia) are novel when R13, R.'\ R15, Rl6f Q and X are as defined above for a compound of formula (I); provided that whenR13, RM, R15 and R16 are each H then X is not CH2 when Q is a double bond and X is not CH2CH2 when Q is a single bond or a double bond; and when R13 is CH3, RH is OCH3 and R1S and R16 are both H then X is not CH2CH2 when Q is a single bond. Therefore, in a further aspect, the present invention provides a compound of formula (da) where R!3, R14, R15, R16, Q and X are as defined above for a compound of formula (I); provided that when R13, R14, R15 and R16 are each H then X is not CH2 when Q is a double bond and X is not CH2CH2 when Q is a single bond or a double bond; and when R13 is CH3, R14 is OCH3 and Rli and R16 are both H then X is not CHJCHJ when Q is a single bond. The compounds of formula (I), (II) and (IHa) may exist as different geometric or optical isomers or in different tautomeric forms. This invention covers, for each formula, all such isomers and tautomers and mixtures thereof in all proportions as well as isotopic forms such as deuterated compounds. The compounds in Tables 1 to 28 below illustrate compounds of the invention. Table 1 provides 59 compounds of formula (H) wherein R1, R2 and Y are as defined in Table 1. Table X represents Table 2 [when X is 2], Table 3 [when X is 3], Table 4 [when X is 4], Table 5 [when X is 5], Table 6 [when X is 6] and represents Table 7 [when X is 7]. Table 2 provides 457 compounds of formula (1-2): wherein R2, R3, R6 and R7 are as defined in Table 2. Table 3 provides 457 compounds of formula (1-3): wherein R2, R3, R6 and R7 are as defined in Table 3. Table 4 provides 457 compounds of formula (1-4): wherein R3, R3, R6 and R7 are as defined in Table 4. Table 5 provides 457 compounds of formula (1-5): wherein R3, R3, R6 and R7 are as defined in Table 5. Table 6 provides 457 compounds of formula (1-6): wherein R2, R3, R6 and R7 are as defined in Table 6. Table 7 provides 457 compounds of formula (1-7): wherein R2, R3, R6 and R7 are as defined in Table 7. Table Y represents Table 8 [when Y is 8], Table 9 [when Y is 9], Table 10 [when Y is 10], Table 11 [when Y is 11], Table 12 [when Y is 12], Table 13 [when Y is 13], Table 14 [when Y is 14], Table 15 [when Y is 15], Table 16 [when Y is 16], Table 17 [when Y is 17], Table 18 [when Y is 18] and represents Table 19 [when Y is 19]. Table 8 provides 364 compounds of formula (1-8): wherein R2, R3,.and R6 are as defined in Table 8. Table 9 provides 364 compounds of formula (1-9): wherein R2, R3, and R6 are as defined in Table 9. Table 10 provides 364 compounds of formula (I-10): wherein R2, R3, and R6 are as defined in Table 10. Table 11 provides 364 compounds of formula (1-11): wherein R2, R3, and R6 are as defined in Table 11. Table 12 provides 364 compounds of formula (1-12): wherein R2, R3, and Rfi are as defined in Table 12. Table 13 provides 364 compounds of formula (1-13): wherein R2, R3, and R are as defined in Table 13. Table 14 provides 364 compounds of formula (1-14): wherein R2, R3, and R6 are as defined in Table 14. Table 15 provides 354 compounds of formula (1-15): wherein R2, R3, and R6 are as defined in Table 15. Table 16 provides 364 compounds of formula (1-16): wherein R2, R3, and R6 are as defined in Table 16. Table 17 provides 364 compounds of formula (1-17): wherein R2, R3, and R* are as defined in Table 17. Table 18 provides 364 compounds of formula (I-I8): wherein R2, R3, and R6 are as defined in Table 18. Table 19 provides 364 compounds of formula (1-19): wherein R2, R3, and R6 are as defined in Table 19. Table Z represents Table 20 [when Z is 20], Table 21 [when Z is 21], Table 22 [when Z is 22], Table 23 [when Z is 23], Table 24 [whenZ is 24] and represents Table 25 [when Z is 25]. Table 20 provides 182 compounds of formula (1-20): wherein R2, R3 and A are as defined in Table 20. Table 21 provides 182 compounds of formula (1-21): wherein R2, R3 and A are as defined in Table 21. Table 22 provides 182 compounds of formula (1-22): wherein R2, R3 and A are as defined in Table 22. Table 23 provides 182 compounds of formula (1-23): wherein R2, R3 and A are as denned in Table 23. Table 24 provides 182 compounds of formula (1-24): wherein R2, R3 and A are as defined in Table 24. Table 25 provides 182 compounds of formula (1-25): wherein R2, R3 and A are as defined in Table 25. Table 26 provides 133 compounds of formula (Ula) where R13, Rw, R15, RIS, Q and X are as defined in Table 26. Q is shown to be either a single bond (•) or a double bond (=). Tabic ZZ represents Table 27 (when ZZ is 27) and represents Table 28 (when ZZ is 28). Table 27 provides 42 compounds of formula 0-27) where R1, R2, R3 and R6 are as defined in Table 9. Table 28 provides 42 compounds of formula (1-28) where R1, R2, R3 and R5 are as defined in Table 10. Throughout this description, temperatures are given in degrees Celsius; "NMR" means nuclear magnetic resonance spectrum; MS stands for mass spectrum; "%" is percent by weight, unless corresponding concentrations are indicated in other units; "syn" refers to a syn configuration of the relevant substituent with respect to the annellated benzene ring; and "anti" refers to an anti configuration of the relevant substituent with respect to the anellated benzene ring. The following abbreviations are used throughout this description: m.p. = melting point b.p.= boiling point, s = singlet br = broad d = doublet dd = doublet of doublets t = triplet q = quartet m = multiplet ppm = parts per million Table 29 shows selected melting point data for compounds of Tables 1 to 28. The compounds according to formula (I) may be prepared according to the following reaction schemes. fat Preparation of a compound of formula (II). Schemes 1,2 and 3 demonstrate that a compound of formula E, H, K, L, N, O, P, R, SjLH-ViiViXOTZ [where R1 and R2 are as defined above for formula (II); and R' is C].s aikyl] {each of which is a compound of formula (U), as defined above} maybe prepared by a reaction sequence starting with a 1,2,3-triazole-4,5-dicarboxylic acid diester of formula A [Y.Tanafca et al., Tetrahedron, 29,3271 (1973)] [where each R' is, independently, Ci-5 alkyl] (preferably the dimethyl ester). Scheme 1 Treatment of A with an alkylating agent [such as R2-halo (where R2 is as defined above for formula (II); and halo is preferably iodo) or an appropriate sulphate, sulphonate or carbonate ester] in the presence of a base [such as K2CO3, Na2C03 or NEt3] in a suitable solvent [such as acetonitrile, DMF or dimethylacetamide] at ambient to elevated temperatures furnishes a mixture of regioisomers, of formulae B and C, which may be separated by conventional methods. Saponification of a compound of formula B with up to one equivalent of a base [such as KOH, NaOH or LiOH] in a protic solvent [such as methanol], preferably under reflux conditions, provides a mono-ester of formula D. Subsequent reaction of a compound of formula D with a fmorinating agent [such as DAST (diethylamino sulphur trifloride) or, preferably, SF4] in the presence of hydrofluoric acid gives a 5-CF3-l,2,3-triazole-4-carboxylic acid ester of formula E. Alternatively, treatment of a compound of formula D with a chlorinating agent [such as thionyl chloride or phosgene] under standard conditions results in an acid chloride of formula F which may be reduced catalytically in an inert solvent [for example ethyl acetate or THF] in the presence of a base [for example Htinig base] to give an aldehyde-ester of formula G (modified Rosenmund conditions). Fluorination of a compound of formula G_ by means of DAST, dimethoxy-DAST or SFt in the presence of hydrofluoric acid, optionally with solvent, preferably at elevated temperatures, forms a 5-difluoromethy3-l,2,3-triazole-4-carboxylic acid ester of formula H. Metal hydride reduction of a compound of formula G [for example by NaBHi or LiBHfl] in methanol provides a 5-hydroxymethyI-l ,2,3-triazole of formula J, from which a 5-fluoromethyl derivative of formula K may be obtained by fluorination under mild conditions, preferably with DAST at low temperatures (0 to -78°C) in an inert solvent [such as dichloromethane]. Alternatively, hydride reduction of a compound of formula J by conventional methods [for example via its mesylate, tosylate or iodide] results in a 5-methyl-1,2,3-triazole of formula L. Chlorination of compound of formula D [for example by thionyl chloride] followed by treatment with ammonia, preferably in a protic solvent [such as water, methanol or ethanol] furnishes an amide of formula M from which a 5-cyano-l ,2,3-triazole of formula N may be obtained by means of a dehydrating agent [such as phosphorylchloride]. Further transformations to prepare a compound of formula (TJ) [where R1 and R2 are as defined above for formula (I); Y is OR' and R' is Q.s alkyl] include iHofinann rearrangement of an amide of formula M with NaOBr or NaOCl in the presence of NaOH to give a 5-amino-l,2,3-triazole of formula O. Diazotation of a compound of formula O by means of sodium nitrite under aqueous acidic conditions [for example sulphuric acid] or with a nitrite ester [for example (0-amyl nitrite] in an organic solvent [for example acetone, dichloromethane or THF] in the presence of a halogenide [such as CuCl or CuBr] gives a 5-halo-l,2,3-triazole of formula P [where halo is CI or Br] which on treatment with a fluorinating agent [such as KFor CsF], preferably in DMF orN-methylpyrrolidone at elevated temperatures, results in a S-fluoro-lAS-triazole of formula V. By diazotation of a compound of formula O and subsequent acidic aqueous hydrolysis under heating, a 5-hydroxy-l ,2,3-triazole of formula Q may be obtained. Treatment of a compound of formula 0_ with an alkylating agent [such as methyl iodide, dimethylsulphate or dimethylcarbonate] and a base [for example NaH, K2COj or Na3C03] in a polar solvent [for example DMF, DMSO or CH3CN] gives a 5-methoxy-l,2,3-triazole of formula R which may be converted to a tricbloromethoxy derivative of formula S with a chlorinating agent [such as chlorine] in the presence of azoisobutyronitrile (AJBN) or ultra-violet irradiation at elevated temperature. By treatment of a compound of formula S with a fluorinating agent [for example KF or SbF3] a 5-trifluoromethoxy~l,2,3-triazole of formula T may be prepared. Oxidation of a compound of formula O with {for example sodium perborate] or treatment according to A. Sudalai et al. [ Angew. Chem. Int. Ed. 40,405 (2001)] leads to a 5-nitro derivative of formula U. Alternatively, a compound of formula U may also be obtained by treatment of a compound of formula P or V with NaNO; in an polar solvent [such as DMF, sulpholane or N-methylpyrrolidone] at elevated temperatures. Transformations of a compound of formula (II') [where R1 and R2 are as defined in ' formula (I); Y is OR'; andR' is Ci-salkyl] to give a compound of formula (II) [where Rl and R1 are as defined in formula (I) and Y is halo or hydroxy] includes saponification with a base [such as KOH or NaOH] in a protic solvent [such as methanol, ethanol or water], at ambient or elevated temperature to give a l,2,3-triazole-4-carboxylic acid of formula W. Chlorination of a compound of formula W under standard conditions [for example with thionyl chloride, phosgene or oxaly] chloride] yields an acid chloride of formula Y. Fluorination of a compound of formula W with DAST or SF4 under mild conditions [low to ambient temperatures], preferably in an inert solvent [such as dichloromethane] gives an acid fluoride of formula Z. fb) Preparation of a compound of formula fllli. A compound of formula (IDQ H2N-A (111) where A is as defined above for a compound of formula (I), is useful as an intermediate in the preparation of a compound of formula (I). Most o-substituted amino-aryls and amino-heteroaryls of formula 0H) are known from the literature, but some are novel. A compound of formula (tQa) may be obtained according to scheme 4: Treatment of an ortAo-substituted nitrobenzonorbomadiene of formula AA (where R13, RM, R15, R16 and X are as defined above for a compound of formula (I)) [obtained through Diels-Alder addition of an in situ generated benzyne, for example, starting from a 6-nitroanthranilic acid as described by L.Paquette et al, J. Amer. Chem. Soc. 99, 3734 (1977) or from other suitable benzyne precursers (see H. PeUissier et al. Tetrahedron, 59, 701 (2003) with a 5-7 membered cyclic 1,4-diene according to, or by analogy to, L.Paquette et al, J. Amer. Chem. Soc. 99, 3734 (1977), D. Gravel et al. Can. J. Chem. 69, 1193 (1991), J.R. Malpass et al. Tetrahedron, 48, 861 (1992), D.E. Lewis et al. Synthetic Communications, 23, 993 (1993), R.N. Warrener et al. Molecules, 6, 353 (2001), R.N. Warrener et al. Molecules, 6,194 (2001) or I. Fleming et al. /. Chem. Soc, Perkin Trans. J, 2645 (1998)] with Zn, in the presence of ammonium chloride or an aluminium amalgam, in a protic solvent [such ethanol or water] gives an aniline of formula CC, whilst catalytic hydrogenation of a compound of formula A4 with, for example, RaNi, Pd/C or Rh/C in the presence of a solvent [for example TKF, ethyl acetate, methanol or ethanol] affords an aniline of formula BB. Compounds of formula (fllb) where R is an aliphatic or alicyclic, saturated or unsaturated group [in which the group contains three to thirteen carbon atoms and at least one silicon atom and, optionally, one to three heteroatoms, each independently selected from oxygen, nitrogen and sulphur, and the group is optionally substituted by up to four independently selected halogen atoms] and R7"10 are as defined in formula (I) may be prepared by analogy with literature examples. References include e.g. E.A.Chernyshew et al., Bull. Acad. Sci. USSR ,1960, 1323; K.T.Kang et al., Tetrahedron Utters, 32, 4341 (1991), Synthetic Comm., 24,1507 (1994); MMurata et al., Tetrahedron Letters 40, 9255 (1999); A.Falcou et al., Tetrahedron 56, 225 (2000); A.Arcadi et al., Tetrahedron Letters 27, 6397 (1986); K.C.Nicolaou et al., Chem.Eur. J. 1, 318 (1995); N.Chatani et al., J.Org. Chem. 60, 834 (1995); T. Stuedemann et al,, Tetrahedron 54, 1299 (1998); P.RHurdlik et al., J. Org. Chem. 54, 5613 (1989); K.Karabelas et al., J. Org. Chem. 51, 5286 (1986); TJeffery, Tetrahedron Letters 40, 1673 (1999) and Tetrahedron Letters 41, S445 (2000); K.01ofson et al., J. Org. Chem. 63, 5076 (1998); H.Uirata et al., Bull. Chem. Soc. Jap. 57, 607 (1984); and G.Maas et al., Tetrahedron 49, 881 (1983); and references cited therein. Recent reviews for the introduction of Si-containing functionalities into phenyl derivatives can be found in "The Chemistry of Organosilicon Compounds", Vols. 1 -3, S.Patai, Z.Rappaport and Z.Rappaport, Y-Apeloid eds., "Wiley 1989, 1998, 2001 and "Houben-Weyl Science and Synthesis", Organometallics Vol. 4, LFleming ed., G.Thieme 2002. Another group of anilines comprises compounds of formula (Die) where R! represents C2-i alkyl, C2.4 haloalkyl or C3-6 cycloalkyl (itself optionally substituted by up to 3 substituents, independently selected from halo, Q.j alkyl, Cu haloalkyl and CM haloalkoxy). A compound of formula (Hie) may be prepared by a reaction sequence starting with a crossed aldol condensation of benzaldehyde with a ketone of formula CHiCfCOR' . [where R' is as defined above for a compound of formula (IHc)] in the presence of NaOH or KOH in a solvent (such as water or ethanol) and usually under reflux conditions or alternatively by reaction of benzaldehyde with a Wittig reagent under standard conditions. The resulting a,p-unsaturated ketone of formula (IV) [where R' is as defined above for a compound (Die)]: may then be converted into a compound of formula (V) [where R' is as defined above for a compound (Hie)]: by reacting first with hydrazine hydrate in ethanol under reflux conditions and then heating (in the range of from 150 to 250°C) in the presence of KOH (distilling off the solvent). After nitration with HNO3-H2O or HNOj-acetic anhydride in a cooled vessel (in the range of from -30°C to 0°C), the resulting o/p-mixture of a nitrobenzene of formula (VI) [where R' is as defined above for a compound (IHc)J: may then be separated and catalytically reduced (Pt/C/ H2 or Ra-Ni/H2) in a solvent (such as methanol, ethanol of THF) at ambient temperature to give a compound of formula (inc). Alternatively the synthesis of a compound of formula (Hid) [where R'a is hydrogen or methyl] may be accomplished by a reaction sequence started by a Wittig reaction of o-nitrobenzaldehyde with an ylide, prepared from a cyclopropylmethyltriphenylphosphonium bromide in the presence of a strong base [such as NaH] in a solvent [such as DMSO], in the range of 0-S5"C. The resulting E/Z-mixtuie of a compound of formula (YD) by the application of the Simmons Smith reaction (Zn-Cu, CH2I2, ether as a solvent) to the olefin group of a compound of formula (YD) to give a compound of formula (VET). The reduction of the nitro moiety of a compound of formula (VIH) to give a compound of formula (Die) may be performed by using the same conditions as described above for a compound of formula (VI). fc) Preparation of a compound of formula (I). Schemes A compound of formula (I) £ where A, R1 and R2 are as defined above and R3 is H] may be synthesized by reacting a compound of formula (IT) [where R1 and R2 are as defined above and R' is C1-5 allcyl] with an aniline of formula (12) [where A is as defined above for a compound of formula (I)] in the presence of NaN(TMS)2 at -10 DC to ambient temperature, preferably in. dry THF, as described by J.Wang et al., Synlett, 2001, 1485, Alternatively, a compound of formula (I) [where A, R1 and R2 are as defined above and R3 is H] may be prepared by reacting a compound of formula (D) [where R1 and R2 are as defined above and Y is OH] with a compound of formula (TH) [where A is as defined above for a compound of formula (I)] in the presence of an activating agent [such as BOP-C1] and two equivalents of a base [such as NEt3] or by reacting a compound of formula (II) [where Y is CI, Br or F] with a compound of formula (IE) in the presence of one equivalent of a base [such as NEt3, NaHCOj, KHCO3, Na2C03 or K2C03] in a solvent [such as dichloromethane, ethyl acetate or DMF] preferably at -10 to 30°C. Scheme 7 A compound of formula (I) [where R3 is as defined above for formula (J), except that it is not hydrogen] may be prepared by reacting a compound of formula (I) [where R3 is hydrogen] with a species Y-R3 [where R3 is as defined for formula (I), except that it is not hydrogen; and Y is halogen, preferably CI, Br or I; or Y is such that Y-R3 is an anhydride: that is, when R3 is COR, Y is OCOR] in the presence of a base [for example NaH, NEt3, NaHCOj or K2CO3] in an appropriate solvent [such as ethyl acetate] or in a biphasic mixture [such as dichtoromethane/water mixturte], at-10 to 30DC. Surprisingly, il has now been found that the novel compounds of formula (I) have, for practical purposes, a very advantageous spectrum of activities for protecting plants against diseases that are caused by fungi as well as by bacteria and viruses. The compounds of formula (I) can be used in the agricultural sector and related fields of use as active ingredients for controlling plant pests. The novel compounds are distinguished by excellent activity at low rates of application, by being well tolerated by' plants and by being environmentally safe. They have very useful curative, preventive and systemic properties and are used for protecting numerous cultivated plants. The compounds of formula I can be used to inhibit or destroy the pests that occur on plants or parts of plants (fruit, blossoms, leaves, stems, tubers, roots) of different crops of useful plants, while at the same time protecting also those parts of the plants that grow later, for example from phytopathogenic microorganisms. It is also possible to use compounds of formula (I) as dressing agents for the treatment of plant propagation material, in particular of seeds (fruit, tubers, grains) and plant cuttings (e.g. rice), for the protection against fungal infections as well as against phytopathogenic fungi occurring in the soil. Furthermore the compounds according to present invention may be used for controlling fungi in related areas, for example in the protection of technical materials, including wood and wood related technical products, in food storage, in hygiene management, etc. The compounds of formula (I) are, for example, effective against the phytopathogenic fungi of the following classes: Fungi imperfecta' (e.g. Botrytis, Pyricularia, Helminthosporium, Fusarium, Septoria, Cercospora and Altemaria) and Basidiomycetes (e.g. Rhizoctonia, Hemileia, Puccinia). Additionally, they are also effective against the Ascomycetes classes (e.g. Venturia and Erysiphe, Podosphaera, Monilinia, Uncinula) and of the Oomycetes classes (e.g. Phytophthora, Pythium, Plasmopara). Outstanding activity has been observed against powdery mildew (Erysiphe spp.). Furthermore, the novel compounds of formula I are effective against phytopathogenic bacteria and viruses (e.g. against Xanthomonas spp, Pseudomonas spp, Erwinia amylovora as well as against the tobacco mosaic virus). Within the scope of present invention, target crops to be protected typically comprise the following species of plants: cereal (wheat, barley, rye, oat, rice, maize, sorghum and related species); beet (sugar beet and fodder beet); pomes, drupes and soft fruit (apples, pears, plums, peaches, almonds, cherries, strawberries, raspberries and blackberries); leguminous plants (beans, lentils, peas, soybeans); oil plants (rape, mustard, poppy, olives, sunflowers, coconut, castor oil plants, cocoa beans, groundnuts); cucumber plants (pumpkins, cucumbers, melons); fibre plants (cotton, flax, hemp, jute); citrus fruit (oranges, lemons, grapefruit, mandarins); vegetables (spinach, lettuce, asparagus, cabbages, carrots, onions, tomatoes, potatoes, paprika); lauraceae (avocado, cinnamomum, camphor) or plants such as tobacco, nuts, coffee, eggplants, sugar cane, tea, pepper, vines, hops, bananas and natural rubber plants, as well as ornamentals. The compounds of formula (I) are used in unmodified form or, preferably, together with the adjuvants conventionally employed in the art of formulation. To this end they are conveniently formulated in known manner to emulsifiable concentrates, eoatable pastes, directly sprayable or dilutable solutions, dilute emulsions, wettable powders, soluble powders, dusts, granulates, and also encapsulations e.g. in polymeric substances. As with the type of the compositions, the methods of application, such as spraying, atomising, dusting, scattering, coating or pouring, are chosen in accordance with the intended objectives and the prevailing circumstances. The compositions may also contain .further adjuvants such as stabilizers, antifoams, viscosity regulators, binders or tackifiers as well as fertilizers, micronutrient donors or other formulations for obtaining special effects. Suitable carriers and adjuvants can be solid or liquid and are substances useful in formulation technology, e.g. natural or regenerated mineral substances, solvents, dispersants, wetting agents, tackifiers, thickeners, binders or fertilizers. Such carriers are for example described in WO97/33890. The compounds of formula (I) are normally used in the form of compositions and can be applied to the crop area or plant to be treated, simultaneously or in succession with further compounds. These further compounds can be e.g. fertilizers or micronutrient donors or other preparations which influence the growth of plants. They can also be selective herbicides as well as insecticides, fungicides, bactericides, nematicides, molluscicides or mixtures of several of these preparations, if desired together with further carriers, surfactants or application promoting adjuvants customarily employed in the art of formulation. The compounds of formula (1) can be mixed with other fungicides, resulting in some cases in unexpected synergistic activities. Mixing components which are particularly preferred are azoles, such as azaconazole, BAY 14120, bitertano!, bromuconazole, cyproconazole, difenoconazole, diniconazole, epoxiconazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, hexaconazole, imazalil, imiben-conazole, ipconazole, metconazole, myclobutanil, pefurazoate, penconazole, pyrifenox, prochloraz, propiconazole, simeconazole, iebuconazole, tetraconazole, triadimefon. triadimenol, triflumizole, triticonazole; pyrimidinyl carbinole, such as ancymidol, fenarimol, nuarimol; 2-ambo-pyrirnidraes, such as bupirimate, dimethirimol, ethirimol; moipholines, such as dodemorph, fenpropidine, fenpropimorph, spiroxamine, tridemorph; anilraopyrirnidines, such as cyprodinil, mepanipyrim, pyrimethanil; pyrroles, such as fenpiclonil, fludioxonil; phenylamides, such as benalaxyl, furalaxyl, metalaxyl, R-metalaxyl, ofurace, oxadixyl; benzimidazoles, such as benomyl, carbendazim', debacarb, Albendazole, thiabendazole; dicarboximides, such as chlozolinate, dichlozoline, iprodione, myclozoline, procymidone, vinclozoline; carboxamides, such as carboxin, fenfurara, flutolanil, mepronil, oxycarboxin, thifluzaraide; guanidines, such as guazatine, dodine, iminoctadine; strobilurines, such as azoxystrobin, kresoxim-methyl, metomi-nostrobin, SSF-129, trifloxystrobin, picoxystrobin, BAS 500F proposed name pyraclostrobin), BAS 520; dithiocarbamates, such as ferbam, mancozeb, maneb, metiram, propineb, thiram, zineb, ziram; N-halomethylthiotetrahydrophthalimides, such as captafol, captan, dichlofluanid, fluoromides, folpet, tolyfluanid; Cu-compounds, such as Bordeaux mixture, copper hydroxide, copper oxychloride, copper sulfate, cuprous oxide, mancopper, oxine-copper; nitrophenol-derivatives, such as dinocap, nitrothal-isopropyl; organo-p-derivatives, such as ediferiphos, iprobenphos, isoprothiolane, phosdiphen, pyrazophos, tolclofos-methyl; various others, such as acibenzolar-S-methyl, anilazine, benthiavalicarb, blasticidin-S, chinomethionate, chloroneb, chlorothalonil, cyflufenamid, cyrnoxanil, dichlone, diclomezine, dicloran, diethofencarb, dimethomorph, SYP-LI90 (proposed name: flumorph), dithianon, ethaboxam, etridiazole, famoxadone, fenamidone, fenoxanil, fentin, ferimzone, fluazinam, Ousulfamide, fenhexamid, fosetyl-aluminium, hymexazol, iprovalicarb, DCF-916 (cyazofamid), kasugamycin, methasulfocarb, metrafenone, nicobifen, pencycuron, phthalide, polyoxins, probenazole, propamocarb, pyroquilon, quinoxyfen, quintozene, sulrbr, triazoxide, tricyclazole, triforine, validamycin, zoxamide (RH7281). A preferred method of applying a compound of formula (I), or an agrochemical composition which contains at least one of said compounds, is foliar application. The frequency of application and the rate of application will depend on the risk of infestation by the corresponding pathogen. However, the compounds of formula I can also penetrate the plant through the roots via the soil (systemic action) by drenching the locus of the plant with a liquid formulation, or by applying the compounds in solid form to the soil, e.g. in granular form (soil application). In crops of water rice such granulates can be applied to the flooded rice field. The compounds of formula I may also be applied to seeds (coating) by impregnating the seeds or tubers either with a liquid formulation of the fungicide or coating them with a solid formulation. A formulation [that is, a composition containing the compound of formula (I)] and, if desired, a solid or liquid adjuvant, is prepared in a known manner, typically by intimately mixing and/or grinding the compound with extenders, for example solvents, solid carriers and, optionally, surface active compounds (surfactants). The agrochemical formulations will usually contain from 0.1 to 99% by weight, preferably from 0.1 to 95% byweight, of the compound of formula I, 99.9 to l%by weight, preferably 99.8 to 5% by weight, of a solid or liquid adjuvant, and from 0 to 25% by weight, preferably from 0.1 to 25% by weight, of a surfactant. Advantageous rates of application are normally from 5g to 2kg of active ingredient (a.i.) per hectare (ha), preferably from lOg to 1kg a.i./ha, most preferably from 20g to 600g a.i./ha. When used as seed drenching agent, convenient dosages are from lOmg to lg of active substance per kg of seeds. Whereas it is preferred to formulate commercial products as concentrates, the end user will normally use dilute formulations. The following non-limiting Examples illustrate the above-described invention in more detail. EXAMPLE 1 This Example illustrates the preparation of Compound No. 1.15 [2-methyl-5-trifluoromethyl-2H-l,2,3-triazole-4-carboxylic acid methyl ester] and Compound No. 1.13 [2-methyl-5-trifluoromethyl-2H-l,2,3-triazole-4-carboxylicacid]. al Preparation of 2-methvt-2H-L2,3-triazole-4.5-dicarboxvlic acid dimethvlester and l-methvl-lH-1.2.3-triazoIe-4.5-dicarboxvlic acid dimethylester. l,2,3-Triazole-4,5-dicarboxylic acid dimethyl ester (Y. Tanaka et al. Tetrahedron 29, 3271 (1973)) (74.06g; 0.40mol), potassium carbonate (110.57g; O.SOmol) and methyl iodide (73.81g; 0.52mol) were reacted in acetonitrile (1000ml) at 40°C for 20minutes and then for 20hours at ambient temperature. The mixture was poured onto ice-water and extracted with ether to give the crude product (70.66g) as a mixture of isomers. Separation on silica gel in ethyl acetate-hexane (2:3) yielded 36.51g (46%) of 2-methyl- 2H-l,2,3-triazole~4,5-dicarboxylic acid dimethylester [m.p. 86-87°C; 'H-NMR (300 MHz, DMSO-de), S(ppm): 4.27(s,3H), 3.88(s,6H)] and 26.92g (34%) qf 1-methyl-1H-1,2,3-triazole-4,5-dicarboxylic dimethylester [m.p. 63-64°C; 'H-NMR (300MHZ, DMSO-ds), 5(ppm): 4.19(s,3H), 3.93(s,3H), 3.87(s,3H)J. b) Preparation of 2-roethvl-2H-l,213-triazole-4.5-dicarboxvlic acid roonomethvl ester To a solution of 2-methyl-2H-l,2,3-triazole-4,5-dicarboxylic acid dimethylester (1.2g;6mmol)in30mlmethanolwasadded358mgKOH(assay 86%; 5.5mmol). The mixture was heated at reflux temperature for 48hours. The solvent was evaporated and the residue was then taken into water and extracted with ethyl acetate (3 times). The combined organic phases contained non-reacted starting material. The aqueous phase was acidified with 2N HC1 (pH2-3) and extracted with ethyl acetate (3 times). The extracts were combined, dried (anhydrous MgS04) and evaporated to dryness to give 803mg (72%) of the desired compound (m.p. 125-126°C; 'H-NMR (300 MHz, DMSO-d6), 8(ppm): 13.7(br.s,lH, exchangable withD20), 4.24(s,3H), 3.84(s,3H). cl Preparation of 2-methvl-5-trifluoromethyl-2H-1.23-triazole-4-carboxvlic acid methyl ester [Compound Number 1.151. 2-Methyl-2H-l,2,3-triazole-4,5-dicarboxylic acid monomethyl ester (2.9g; 15.66mmol) and dichloromethane (160ml) were placed in an 0.31itre monel autoclave. Under an inert atmosphere and cooling with dry ice, gaseous HF (27g) was introduced at -50°C followed by gaseous SF4 (distilled, 6.9g; 64.23mmol). The autoclave was heated to 80°C for 6houra. The maximum pressure amounted 9.8bar. After cooling to ambient temperature the reaction mixture was poured onto ice-dichloromethane and adjusted to pH7 with aqueous NaHCOa. Extraction with dichloromethane (3 times), drying over Na2S04 and evaporation under reduced pressure afforded the crude product. Purification by Kugelrohr-distillation at 3mbar and ca.l80°C gave 2.8g (85%) of Compound No.l .15 as a yellowish liquid. 'H-NMR (300 MHz, CDCU), 5(ppm): 4.29(s,3H), 3.97(s,3H); ,9F-NMR (235 MHz, CDClj), 5 (ppm): -61.7. ,3C-NMR(125MHz,CDCl3),6(ppm): 159.05,139.65(^^^ = 40.8 Hz), 137.20, 119.63 (q, 3CF = 269.4 Hz, CF3), 52.96, 43.01. dl Preparation of 2-methvl-5-trifluoromethvl-2H-l,2,3-triazole-4-carboxylic acid rCompound Number1.131 A solution of 2-methyl-5-trifluoromethyl-2H-l,2,3-triazole-4-carboxyIic acid methyl ester [Compound Number 1.15] (2.09g; O.Olmol) and KOH (86 %; 0.783g; 1.2eq.) in THF (50ml) was heated at reflux temperature for 3.5 hours. The solution was evaporated, the residue was dissolved in water and acidified to pH 1-2 with HC1 (1M). Evaporation of the aqueous solution followed by continuous extration in ethylacetate for 20 hours gave of Compound No 1.13 (2.1 Ig; 100%) as a crystalline solid. 'H-NMR (400 MHz, DMSO-d6), 5(ppm): 4.19(s,3H). I9F-NMR (235 MHz, DMSO-d6), 6 (ppm): -59.3, l3C-NMR (125 MHz, DMSO-d6), fifppm): 160.74, 144.08, 135.81 (q, Jc EXAMPLE 2 This Example illustrates the preparation of Compound No. 1.03 [2-methyl-5-difluoromethyl-2H-l,2,3-triazole-5-carboxylic acid methyl ester]. a) Preparation of 5-Chlorocarbonvl-2-methvl-2H-1.2.3-triazole-4-carboxylic acid methyl ester. Methyl 2-methyl-I,2,3-triazole-4,5-dicarboxylate (2.3g; O.Ollmol) was reacted withoxalyl chloride (1.46ml; 0.014mol)plus two drops ofDMFmdichlorornethane (20ml) at 20°C. When the vigourous reaction ceased the temperature was raised to reflux for 15hours. The mixture was evaporated to dryness to give 2.7g of the acid chloride as a solid. 'H-NMR (300 MHz, CDC13), 5 (ppm): 4.48(s, H), 4.0(s,3H). b) Preparation of 5-fonnvl-2-methvl-2H-l,2.3-triazole-4-carboxvlic acid methyj ester. To a solution of freshly prepared 5-ChlorocarbonyI-2-methyl-2H-l,2,3-triazole-4-carboxylic acid methyl ester (2.7g; ca. 13mmoi) in THF (270 m!) was added ethyl-diisopropyl-amine(1.88g; l.leq.). The mixture was hydrogenated in the presence of 2.7g 10% Pd/C at 0-5°C at normal pressure for 2'/2 hours and subsequently filtered from the catalyst. The clear solution was evaporated to give the crude as a solid which was dissolved again in ethyl acetate and stirred for a couple of minutes with silica gel. After filtration and evaporation 1.77 g (84%) of pure product as off-white crystals were obtained [m.p. 107-108°C; 'H-NMR (300 MHz, CDC13), 5 (ppm): 10.43(s,lH), 4.33(s,3H),4.01(s,3H)]. cl Preparation of 2-methvl-5-difluoromethyl-2H-l,2.3-triazole-5-carboxylic acid methyl ester. [Compound No.1.03.] 5-Formy]-2-methyI-2H-l,2,3-triazole-4-carboxylic acid methyl ester (600mg; 3.5mmoI) in 0.5ml CHCU were reacted with (bis(2-methoxyethyl)amino) sulfurtrifluoride (1350mg;6.1mmol)3t ambient temperature to 50°C for 6days. The resulting orange solution was carefully quenched with 6m! of a saturated aqueous NaHCOj solution (vigorous reaction) and extracted with ethyl acetate (twice). The combined organic phases were washed with aqueous NaHCCvsolution, dried over anhydrous MgS04 and evaporated to give 351mg (52%) of colourless crystals. 'H-NMR (300MHZ, CDC13), 5 (ppm): 7.15(t, JHF = 53.5 Hz, 1H, H-CF2), 4.30(s,3H), 3.98(s,3H); ^F-NMR (235 MHz, CDCI3), 5 (ppm): -116.1; ,3C-NMR (125MHz,CDCb), S (ppm): 160.0,143.6 EXAMPLE3 This Example illustrates the preparation of Compound No.l .50 [2-methyI-5-fluorornethyl-2H-l,2,3-triazole-5-carboxylic acid methyl ester]. al Preparation of 5-hvdroxvmethvl-2-methyl-2H-l,2,3-triazole-4-carboxylic acid methyl ester. 2.6g (13.3mmol) of 5-formyl-2-methyl-2H-l,2,3-triazole-4-carboxylic acid methyl ester (see Example 2a) in methanol (100ml) was treated with NaBH4 (601mg) under stirring for lhour at ambient temperature. The reaction mixture was quenched with saturated aqueous ammonium chloride solution, extracted with ethyl acetate, dried with Na2S04 and evaporated to give the crude as an oil. Purification on silica gel in ethyl acetate : hexane (2:1) yielded 1.85g (81%) of the crystalline product,m.p. 112-113°C. 'H-NMR (300MHZ, CDC13), 5 (ppm): 4.86(d, J= 6.9 Hz, 1H), 4.22(s,3H), 3.98(s,3H), 3.53(t; /- 6.9 Hz, exchangeable with D20). bl Preparation of 2-methvl-5-fluoromethyl-2H-l,2,3-triazole-5-carboxylic acid methyl ester. [CompoundNo.1.50.] A solution of 5-hydroxymethyl-2-methyl-2H-l,2,3-triazole-4-carboxylic acid methyl ester (200mg; 1.Immol) in CHjCb (15ml) was reacted with 0.26ml diethylamino sulfurtrifluoride (2mmol) for ISminutes at-40°C followed by 15hours at ambient temperature. After evaporation, the crude product was purified on silica gel in ethyl acetate : hexane (3:1) to give lSlmg (95%) of the desired product, m.p. 64-66°C. 'H-NMR (300MHZ, CDC13), 5 (ppm): 5.66(d, JHF - 47.5 Hz, 2H, Hj-CF), 4.26(s,3H), 3.96(s,3H). 19F-NMR (235 MHz, CDCI3), 5 (ppm): -214. !3C-NMR (125MHz, CDCb), 5 (ppm): 161.6, 145.86 (&,JC(5>F~ 18.7 Hz) , 137.09, 74.82(d,/cF= 166.6 Hz, CH2F), 52.2,42.3. EXAMPLE 4 This Example illustrates the preparation of Compound No.3.017 [5-difluoromethyl-2-methyl-2H-1,2,3-triazole-4-carboxylic acid (4'-chloro-biphenyl-2-yl}-amidej. To a solution of 2-methyl-5-difJuoromethy]-2H-l,2,3-triazoIe-5-carboxylic acid methyl ester (300mg; 1.57mmoI) and 4'-chIoro-bipb.enyl-2-ylamine (320mg; 1.57mmol) in THF (3ml) was added sodium bis(trimethylsilyl)-amide (0.88ml 2M in THF; 1.76mmoI; 1.12eq.) by syringe at 0°C over 1,5minutes. The reaction mixture was stirred at 0°C for 15minutes and then at ambient temperature for 22 hours. It was then poured on cold saturated NH4CI solution and extracted with ethyl acetate. After washing with brine it was dried (anhydrous MgSCv) and evaporated to dryness to give a solid, which was triturated with hexane. The colourless crystalline product was filtered and dried: 300rag (53%) [m.p. 155-156°C; 1H-NMR (300MHz, CDCIj), 5 (ppm): 8.5(br, exchangeable with D20,1H), 8.4 (d, 1H), 7.5-7.2(m,7H), 7.38 {UJHF™ 52.5 Hz,lH, CHF2), 4.2(s,3H), LC-MS:363(M+H)]. EXAMPLE 5 This Example illustrates the preparation of Compound No.2.219 [2-methyl-5-trifluoromethyl-2H-l,2,3-triazole-4-carboxylicacid [2-(l,3-dimethyl-butyl)-phenyl]-amide]. To a solution of 2-methyl-5-trifluoromethyl-2H-1,2,3-triazole-4-carboxylic acid methyl ester (150mg; 0.75mmol) and2-(l,3-dimethyl-butyl)-phenylainiiie (133mg; O.75mmol) in 1.5ml THF was added sodium bis(trimethylsilyl>amide (0.638ml 2M in THF; 1.7eq.) by syringe at ambient temperature. The reaction mixture was stirred for 20hours and was then poured on cold saturated NH4CI solution and extracted with ethyl acetate. After washing with brine it was dried (anhydrous MgSO-O and evaporated to dryness to give the crude product, which was purified on silica gel in cyclohexane-ethyl acetate (18:1) The crystalline product was triturated in hexane, filtered and dried in vacuo to yield 130mg (49%) of Compound No. 2.219 [mp 94.6-95 A°C; 1H-NMR (300MHz} CDCtj), 8 (ppm); 8.5(br.s, exchangeable with D20,1H), 8.0(d,lH), 7.3-7.15(m,3H), 4.33(s,3H), 3.0(m,lH), L55-l,35(m,3H), 1.26(d,3H), 0.9(2d,6H); LC-MS: 355.6{M+H)]. EXAMPLE 6 This Example illustrates the preparation of Compound No.26.014 [1,8-Dimethyl-1 ] -oxa-tricyclo[6.2. J .02.7]undeca-2,4,6-trien-3-yI-amine]. A solution of l,4-dimethyl-5-nitro-l,4-dihydro-l,4-epoxynaphthalene(5.49g; 25.27mmol) (see T. Nishiyama et aL, Rikagaku-hen, 28, 37-43 (2000)) in 55ml THF was hydrogenated in the presence of RaNi (l.lg) at ambient temparature. Hydrogen uptake was2.231itre(97%) after 18hours. After filtering off the catalyst, the filtrate was evaporated and taken into ether, washed with aqueous NaHCOrsoIution and dried (NaSO.0to give 4.60g of crude product, as an oil. Trituration with hexane and a trace of ether furnished a total of 4.5g (94%) of reddish crystalline product, m.p.92-93°C. 'H-NMR(300MHz, CDC13), 6 (ppm): 7.05(t,lH), 6.7(t,2H), ca.5(br.,exchangeablewithD2O,2H),2.0(s,3H),1.9(m,2H), 1.8(s,3H), 1.7(m,lH), I.S(m,IH). EXAMPLE 7 This Example illustrates the preparation of Compound No.26.001 [] ,8-DimethyJ-ll-oxa-tricyclo[6.2.1.02.7]undeca-2,4,6,9-tetraen-3-yl-aniine]. To l,4-dimethyl-5-nitro-l,4-dihydro-l,4-epoxynaphthalene (4.22g; 19.43mmol) (see Example 6) in ethanol (60ml) was added a solution of amrnoniumchloride (2.08g) in H2O (5.2ml) at 47°C. Under vigorous stirring, zinc powder (9.10g; 0.14mol) was added in portions over a period of 5minutes. The suspension was heated to reflux for 5'/ihours followed by filtration through Hyflo to give a clear yellow filtrate. After evaporation, the crude product amounted 4.57g, as a viscous oil. Column chromatography on silica gel in ethyl acetate-hexane (1:4) gave 1.24g (34%) of the desired product, as brownish crystals, m.p. 92-96DC. 'H-NMR (300 MHz, CDCb), 5(ppm): 6.85 and 6.7(two m, 2x2H), 6.47 FORMULATION EXAMPLES FOR COMPOUNDS OF FORMULA O) Working procedures for preparing formulations of the compounds of formula I such as Emulsifiable Concentrates, Solutions, Granules, Dusts and Wettable Powders are described in WO97/33890. BIOLOGICAL EXAMPLES: FUNGICIDAL ACTIONS Example B-1: Action against Puccinia recondita / wheat (Brownrust on wheat) 1 week old wheat plants cv. Arina are treated with the formulated test compound (0.02% active ingredient) in a spray chamber. One day after application, the wheat plants are inoculated by spraying a spore suspension (lxl05uredospores/ml) on the test plants. After an incubation period of 2 days at 20°C and 95%r.h. the plants are kept in a greenhouse for 8days at 20CC and 60%r.h. The disease incidence is assessed 1 Odays after inoculation. Infestation is prevented virtually completely (0-5% infestation) with each of Compounds 2.273, 3.219, 3.273, 3.321, 8.189,9.189, 20.017, 20.022, 21.017 and 21.022. Example B-2: Action against Podosphaera leucotricha / apple fPowdervmildew on apple) 5 week old apple seedlings cv. Mcintosh are treated with the formulated test compound (0.02% active ingredient) in a spray chamber. One day after, the application apple plants are inoculated by shaking plants infected with apple powdery mildew above the test plants. After an incubation period of 12 days at 22°C and 60%r.h. under a light regime of 14/10hours (light/dark) the disease incidence is assessed. Compounds 2.005, 3.017, 3.219 and 9.189 each exhibit strong efficacy ( 4 week old apple seedlings cv. Mcintosh are treated with the formulated test compound (0.02% active ingredient) in a spray chamber. One day after application, the apple plants are inoculated by spraying a spore suspension (4xl05conidia/ml) on the test plants. After an incubation period of 4 days at21°C and95%r.h. the plants are placed for ) 4 days at 21°C and 60%r.h. in a greenhouse. After another 4 day incubation period at 21°C and 95%r.h. the disease incidence is assessed. Compounds 3.017, 3.219 and 9.189 each exhibit strong efficacy ( Example B-4: Action against Erysiphe graminis / barley ("Powdery mildew on barlevl 1 week old barley plants cv. Regina are treated with the formulated test compound (0.02% active ingredient) in a spray chamber. One day after application, the barley plants are inoculated by shaking powdery mildew infected plants above the test plants. After an incubation period of 6 days at 20DC /18°C (day/night) and 60%r.h. in a greenhouse the disease incidence is assessed. Compounds 2.017,2.029, 2.273, 3.005, 3.017,3.029, 3.067, 3.070, 3.219, 3.273, 3.321,3.407, 8.189, 9.189 and21.017 each exhibit strong efficacy ( 5 week old grape seedlings cv. Gutedel are treated with the formulated test compound (0.02% active ingredient) in a spray chamber. Two days after application, the grape plants are inoculated by spraying a spore suspension (1x10 conidia/ml) on the test plants. After an incubation period of 4 days at 21"C and 95%r.h. in a greenhouse the disease incidence is assessed. Compounds 2.029, 3.017 and 3.219 each show good activity in this test ( 4 week old tomato plants cv. Roter Gnom are treated with the formulated test compound (0.02% active ingredient) in a spray chamber. Two days after application, the tomato plants are inoculated by spraying a spore suspension (lxl0iconidia/ml) on the test plants. After an incubation period of 4 days a( 20°C and 95%r.h. in a growth chamber the disease incidence is assessed. Compounds 2.029,3.005, 3.029, 3.067, 3.070,3.219, 3.273, 9.189 and 20.017 each exhibit good efficacy ( 1 week old wheat plants cv. Arina are ireated with 1hs formulated test compound (0.02% active ingredient) in a spray chamber. One day after application, the wheat plants are inoculated by spraying a spore suspension (5x103conidia/ml) on the test plants. After an incubation period of 1 day at 20°C and 95%r.h. the plants are kept for 10 days at 20°C and 60%r.h. in a greenhouse. The disease incidence is assessed 11 days after inoculation. Compounds 3.273 and 9.189 each show good activity in this test ( Example B-8: Action against Helminthosporium teres / barley (Net blotch on barley-) ] week old barley plants cv. Regina are treated with the formulated test compound (0.02% active ingredient) in a spray chamber. Two days after application, the barley plants are inoculated by spraying a spore suspension (3x 104conidia/ml) on the test plants. After an incubation period of 4 days at 20°C and 95%r.h. in a greenhouse the disease incidence is assessed. Compounds 2.005,2.017, 2,029, 2.067, 2.070, 2.273, 3.005, 3.017, 3.029, 3.067, 3.070, 3.219, 3.407,9.189 and 21.017 each show good activity in this test ( 4 week old tomato plants cv. Roter Gnom are treated with the formulated test compound (0.02% active ingredient) in a spray chamber. Two days after application, the tomato plants are inoculated by spraying a spore suspension (2xl05conidia/ml) on the test plants. After an incubation period of 3 days at 20°C and 95%r.h. in a growth chamber the disease incidence is assessed. Compounds 2.005, 2.029, 3.005, 3.017, 3.029 and 9.189 each show good activity in this test ( 5 week old grape seedlings cv. Gutedel are treated with the formulated test compound (0.02% active ingredient) in a spray chamber. One day after application, the grape plants are inoculated by shaking plants infected with grape powdery mildew above the test plants. After an incubation period of 7 days at 26°C and 60%r.h. under a light regime of 14/1 Ohours (light/dark) the disease incidence is assessed. Compounds 3.017, 3.219 and 9.189 each show good activity in this test ( WE CLAIM: 1. A compound of formula (I): (A22) wherein Q is a single or a double bond; X is O, N(R,R) or (CR19R30){CR2,R")m(CR"R24)„; R1 is Ci^haloalkyl; R1 is CM alkyl or CM aJkoxy(CM)alkyl; R3 is hydrogen; R^R^R^R^andR17 arc each, independently, hydrogen orCw alkyl; R,B is hydrogen. CM alkyl, formyl, C(=0)CM alkyl or C(-0)0-Cu alkyl; R,p, R30, K2\ RM, R" and RM are each, independently, Ci-6 alkyl, optionally substituted by aryl, a 3-7 meinbered carbocyclic ring or hydrogen; or R'ROT together with the carbon atom to which they are attached form a 3-5 membered carbocyclic ring or Q ^ alkylidcne (optionally substituted by up to three methyl groups); m is 0 or I; and nisO. 2. An intermediate for the preparation of formula (I) according to claim 1, having the formula where R1 and R1 are as dcGned in claim 1 and Y is halogen, hydroxy or C1.5 alkoxy, provided that when R1 is chtoro and K2 is 4-CHjO-C(H4-CH2-, Y is not C2H3O; when R1 is CHjO and R1 is CHi, Y is not CJHJO; when R1 is bromo and Rz is CH3OCH2, Y is not CH3O; and when R is CHj and R2 is CJHJ, Y is not OH. 3. An intermediate for the preparation of formula (I) according to claim 1, having the formula where R,J, R14, R1 \ R,fl, X and Q are as defined in claim 1; provided that when R", R14, R1 s and R, 4. A composition for controlling microorganisms and preventing attack and infestation of plants therewith, wherein the active ingredient is a compound of formula (I) as claimed in claim 1 together with a suitable carrier. 5. A method of controlling or preventing infestation of cultivated plants by phytopathogenic microorganisms by application of a compound of formula (I) as claimed in claim 1 to plants, to parts thereof or the locus thereof. Dated this 31 day of December 2004

Full Text

The present invention relates to novel 1,2,3-triazole derivatives which have microbiocidal activity, in particular fungicidal activity. The invention also relates to novel intermediates used in the preparation of these compounds, to agrochemical compositions which comprise at least one of the novel compounds as active ingredient and to the use of the active ingredients or compositions in agriculture or horticulture for controlling or preventing infestation of plants by phytopathogenic microorganisms, preferably fungi.
The present invention provides a compound of formula (I):

(A22) Q is a single or a double bond; X is O, N(R1B), S or (CR19R20XCR2,R22)B1(CR2JRM)B: R1 is halogen, cyano, nitro, Cualkyl, CMhaloalkyl, CM alkoxy, CM haloalkoxy or optionally substituted CM alkenyl, optionally substituted CM alkynyl or optionally substituted S02(CM Jalkyl (where the optionally substituted moieties may each have up to 3 substituents, each independently selected from halogen and CM alkoxy); R2 is CM alkyl, CM haloalkyl, CM alkoxy(CM)alkyl or CMaUcylthio(CM)alk:yl or [optionally substituted aryl](CM)alkyl- or [optionally substituted aryl]oxy(CM)alkyl- (where the optionally substituted aryl moieties may each have up to 3 substituents, each independently selected from halogen and CM alkoxy); R3 is hydrogen, CH2C;€R4, CH2CR4=C(H)R\ CH=C=CHj or COR5 or optionally substituted CM alkyl, optionally substituted CM alkoxy or optionally substituted (CM) alkylC(=0)0 (where the optionally substituted moieties may each have up to 3 substituents, each independently selected from halogen, CM alkoxy, CM alkyl, C^ haloalkoxy, hydroxy, cyano, carboxyl, methoxycarbonyl, ethoxycarbonyl, methylsulfonyl and ethylsulfonyl); each R* is, independently, hydrogen, halogen, Chalky!, CMhaloalkyl, C\^a\koxyoiCi^alkoxy(Ci^)a\kyl; Rs is hydrogen or optionally substituted Cu alkyl, optionally substituted CM alkoxy, optionally substituted CM alkoxy(Ci^)alkyl, optionally substituted CM alkylthio(CM)alkyl or optionally substituted aryl (where the optionally substituted moieties may each have up to 3 substituents, each independently selected from halogen, Cj-g alkoxy, Ci-e haloalkoxy, cyano, hydroxy, methoxycarbonyl and ethoxycarbonyl); R6 is phenyl [optionally substituted by up to 3 substituents, each independently selected from halogen, cyano, nitro, CM alkyl, CM haloalkyl, CM alkoxy, CM haloalkoxy, CM haloalkylthio, C(H)=N-OH, C(H)=N-0(Ci.6 alkyl), C(Ci4 alkyl)=N-OH, C(CM alkyl)=N-0-(C,.6 alkyl), (Z)pCsCR25 and (Z)pCR28=CR26R27j, a 5-6 membered heterocyclic ring [in which tie ring contains 1 to 3 heteroatoms (each independently chosen from oxygen, sulphur and

nitrogen) and the ring is optionally substituted by up to 3 substituents, each independently selected from halogen, cyano, nitro, CM alkyl, CM haloalkyl, CM alkoxy, CM haloalkoxy, C(HJ=N-0-(Ci-6 alkyl) and C(C,.6 alkyl)=N-0-(C,-6 alkyl)], C3.12 alkyl [optionally substituted by up to 6 substituents, each independently selected from halogen, cyano, CM alkoxy, CM thioalkyl, COO-CM alkyl, =N-OH, =N-0-(CM alkyl), C j.g cycloalkyl (itself optionally substituted by up to 3 substituents, each, independently selected from CM alkyl, halogen, CM alkoxy and CM haloalkoxy) and C4-g cycloalkenyl (itself optionally substituted by up to 3 substituents, each independently selected from CM alkyl, halogen, CM alkoxy and CM haloalkoxy)], C2-12 alkenyl [optionally substituted by up to 6 substituents, each independently selected from halogen, cyano, C\^ alkoxy, CM thioalkyl, COO-(CM alkyl), =N-OH, =N-0-(CM alkyl), C3.g cycloalkyl (itself optionally substituted by up to 3 substituents, each independently selected from CM alkyl, halogen, CMalkoxy and CM haloalkoxy) and C4.B cycloalkenyl (itself optionally substituted by up to 3 substituents, each independently selected from CM alkyl, halogen, CM alkoxy and C\^ haloalkoxy)], C202 alkynyl [optionally substituted by up to 6 substituents, each independently selected from halogen, cyano, CM alkoxy, CM thioalkyl, COO-CM alkyl, =N-OH, =N-0-(CM aikyl), C3.g cycloalkyl (itself optionally substituted by up to 3 substituents, each independently selected from CM alkyl, halogen, CM alkoxy and CM haloalkoxy), Si(CH3)3 and C4.B cycloalkenyl (itself optionally substituted by up to 3 substituents, each independently selected from CM alkyl, halogen, CM alkoxy and CM haloalkoxy)], C3.a cycloalkyl [optionally substituted by up to 3 substituents, each independently selected from halogen, CM alkyl, CM haloalkyl, CM alkoxy, CM haloalkoxy, CM thioalkyl, C3.6 cycloalkyl (itself optionally substituted by up to 3 substituents, each independently selected from CM alkyl, halogen, CM alkoxy and CM haloalkoxy) and phenyl (itself optionally substituted by up to five independently selected halogen atoms)], C4-6 cycloalkenyl [optionally substituted by up to 3 substituents, each independently selected from halogen, CM alkyl, CM haloalkyl, CM alkoxy, CM haloaucoxy, CM thioalkyl, C3.6 cycloalkyl (itself optionally substituted by up to 3 substituents, each independently selected from CM alkyl, halogen, CM alkoxy and CM haloalkoxy) and phenyl (itself optionally substituted by up to five independently selected halogen atoms)], C6.]2 bicycloalkyl [optionally substituted by up to 3 substituents, each independently selected from halogen. CM alkyl and CM haloalkyl] or an aliphatic,

saturated or unsaturated group [in which the group contains three to thirteen carbon atoms and at least one silicon atom and, optionally, one to three heteroatoms, each independently selected from oxygen, nitrogen and sulphur, and the group is optionally substituted by up to four independently selected halogen atoms]; R7, Rs, R9, R10, R11 and R12 are each, independently, hydrogen, halogen, cyano, nitro, CM alkyl, CM haloalkyl, CM alkoxy, CM haloalkoxy, CM thioalkyl or CM thiohaloalkyl; R13, RM, RiS, R16 and R17 are each, independently, hydrogen, halogen, CM alkyl. C(0)CH3, CM haloalkyl, CM alkoxy, CM haloalkoxy, CM thioalkyl, CM thiohaloalkyl, hydroxymethyl or CM alkoxymethyl; RIS is hydrogen, CM alkyl, CM alkoxy(CM)aIkyl, formyl, C(=0)CM alkyl (optionally substituted by halogen or Ci-4-alkoxy) or C(=0)0-Cj^ alkyl (optionally substituted by halogen, CM alkoxy or CN); R19, R2°, R21, R22, R23 and R24 are each, independently, Ci-6 alkyl, CM alkenyl [both optionally substituted by halogen, hydroxy, =0, CM alkoxy, 0-C(0)-CM alkyl, aryl or a 3-7 rnembered carbocyclic ring (itself optionally substituted by up to three methyl groups)], a 3-7 rnembered carbocyclic ring (optionally substituted by up to three methyl groups and optionally containing one heteroatom selected from nitrogen and oxygen), hydrogen, halogen, hydroxy or CM alkoxy, or Rl9R20 together with the carbon atom to which they are attached form a carbonyl-group, a 3-5 rnembered carbocyclic ring (optionally substituted by up to three methyl groups), CM alkylidene (optionally substituted by up to three methyl groups) or C3-e cycloalkylidene (optionally substituted by up to three methyl groups); R25 is hydrogen, halogen, CM alkyl, CMhaloalkyl, CM alkoxy(Ci^)alkyl, CMhaloalkoxy{CM)alkyl or S1(CM alkyl)3; R26 and R27 are each, independently, hydrogen, halogen, CM alkyl or CM haloalkyl; R28 is hydrogen, CM alkyl or CM haloalkyl; mis 0 or l;n is 0 or 1; pis 0 or l;andZis CM alkylene.
Halogen is fluoro, chloro, bromo or iodo.
Each alkyl moiety is a straight or branched chain and is, for example, methyl, ethyl, n-propyl, n-butyl, H-pentyl, /i-hexyl, wo-propyl, sec-butyl, wo-butyl, tert-butyl, Heo-pentyi, H-heptyl, 1,3-dimethylbutyf, 1,3-dimethylpentyl, l-methyl-3-ethyl-butyl or 1,3,3-trimethylbutyl.
Haloalkyl moieties are alkyl moieties which are substituted by one or more of the same or different halogen atoms and are, for example, CF3, CF2C1, CHF2, CH2F, CC13, CFjCH?, CHF2CH2, CH2FCH2, CH3CHF or CH3CF2.

Alkenyl and alkynyl moieties can be in the form of straight or branched chains. The alkenyl moieties, where appropriate, can be of either the (E)- or (Z)-configuration. Examples are vinyl, allyl, ethynyl and propargyl.
Alkylidene moieties can be in the form of straight or branched chains. Alkylidene includes methylidene [CH2=C], ethylidenc [CHjC(H)=C], u-propylidene, i-propylidene [(Cfb^OC], n-butylidene, /-butylidene, 2-butylidene, H-pentylidene, i-pentylidene, neo-pentylidene, 2-pentylidene, n-hexylidene, 2-hexylidene, 3-hexylidene, i-hexylidene and Jieo-hexylidene.
Cycloalkyl includes cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl and cyclooctyl.
Cycloalkenyl includes cyclobutenyl, cyciopentenyl, cyclohexenyl and cycloheptenyl
Cycloalkylidene includes cyclopropylidene [c(CjH4)=C], cyclobutylidene, cyclopentylidene and cyclohexylidene.
Bicycloalkyl includes bicyclo[l,l,l]pentyl, bicyc!o[2,l,l]hexyl, bicycIo[2,2,l]heptyl, bicyclo[2,2,2]octyl, bicyclo[3,2,l]octyl and bicyclo[3,2,2]nonyl.
Aryl includes phenyl, naphthyl, anthracyl, fluorenyl and indanyl but is preferably phenyl.
In one aspect of the invention, A is as defined above provided that it is not (Al).
In another aspect of the invention, R6 is as defined above provided that it is not an aliphatic, saturated or unsaturated group [in which the group contains three to thirteen carbon atoms and at least one silicon atom and, optionally, one to three heteroatoms, each independently selected from oxygen, nitrogen and sulphur, and the group is optionally substituted by up to four independently selected halogen atoms].
In a further aspect of the invention, A is as defined above provided that it is not (Al) when R6 is an aliphatic, saturated or unsaturated group [in which the group contains three to thirteen carbon atoms and at least one silicon atom and, optionally, one to three heteroatoms, each independently selected from oxygen, nitrogen and sulphur, and the group is optionally substituted by up to four independently selected halogen atoms].
Preferably Q is a single bond.
Preferably n is 0,
Preferably m is 0.

Preferably A is selected from formulae (Al), (A2), (A3), (A16), (A17), (A18), (AI9),(A20)and(A22).
More preferably A is selected from formulae (Al), (A2), (A1S), (A19) and (A22).
Even more preferably A is selected from one of the following ortho-substituted rings:

Preferably X is O, NR18 or (CRl9R20)(CR21R22)m(CR23R24)„. MorepreferablyXisOorCCR'V^CR^R^WCR^R24^. Even more preferably X is (CR19R20)(CR2iR22)m(CR23R24)n. . Most preferably X is (CRI9R20).
Preferably R1 is C, A alkyl, Cw haloalkyl, NOa, CN or OCF3. More preferably R! is CHF2, CF3, CH2F, CF2C1, CH3 or C2H5. Even more preferably R1 is CHF2, CF3, CH2F, CF2C1 or CH3. Most preferably R1 is CHF2, CF3 or CH2F. Preferably R2 is CM alkyl, CM haloalkyl, CM alkoxy(CM)alkyI or ClJ(alkylthio(C!.4)alkyl.
More preferably R2 is CH3, CF3, C2Hi, CH2OCH3 or CH2SCH3.
Even more preferably R2 is CH3 or C2Hs.
Most preferably R2 is CH3.
Preferably R3 is hydrogen, CH2C =CR4, CH2CR4=C(H)R4, CH=OCH2 or COR5.
More preferably R3 is H, CH2C *£H, CH=C=CH2, CH2CH=CH2 or COCH3.
Still more preferably R3 is H, CH2CM:H, CH=C=CH2 or CH2CH=CH2.
Even more preferably R3 is H, CH2C s€H or CH=C=CH2.
Most preferably R3 is H.
Preferably each R is, independently, H, halogen, Ci^alkylorCi-ialkoxy.

More preferably each R4 is, independently, H, CI, Br, CH3 or CHjO.
Still more preferably each R4 is, independently, H, CI or CH3,
Most preferably each R4 is H.
Preferably R3 is H, Ci.6 alkyl, CM alkoxy or CM alkoxy(CM)aIkyl.
More preferably R5 is H, methyl, OC(CH3)3 or CH:OCH3.
Even more preferably R5 is H or methyl.
Preferably Rs is chosen from C3-i0 alkyl, C3.9 haloalkyl, C3-7 cycloalkyl [optionally substituted by C3 cycloalkyl (itself optionally substituted by C1-2 alkyl) or by up to two CM alkyl groups], an aliphatic group [which contains three to ten carbon atoms and at least one silicon atom and, optionally, one oxygen atom], thienyl [optionally substituted by halo], furyl [optionally substituted by halo], pyridyl [optionally substituted by halo], oxazolyl, isoxazolyl and

where Rc and Rd are, independently, H, CI, Br, F, I, CN, N02, CM alkyl, CF3, SCF3, OCF3, CH=NOH, CH=N-OCu alkyl, C^CH, OC-Si(CH3)3, C(H)=CH2 or C(HKH(CH alkyl)-
More preferably R6 is C3-7 alkyl, C3_e cycloalkyl [optionally substituted by CM alkyl or a C3 cycloalkyl (itself optionally substituted by C\.2 alkyl)], an aliphatic group (which contains three to eight carbon atoms and at least one silicon atom) or

where Re is Ci, Br, F, CF3, OCF3, CH=N-OCM alkyl, C=CH, C=C-Si(CH3)3 or C(H)=CHj [in one aspect it is preferred that Rc is CI, Br, F, CF3, OCF3, CH=N-OC,.4 alkyl, CsCH or C(H)=CH2].

Even more preferably R is chosen from one of the following moieties:

where Re is CI, Br, F, CF3, OCH, OC-Si(CH3)3 or CH=N-OCM alkyl [in one aspect it is preferred that Re is CI, Br, F, CF3, C^CH or CH=N-OCM alkyl]-
Preferably R7 is H, F or CH3.
Preferably R8 is H.
Preferably R9 is H.
Preferably R10 is H.
Preferably R" is H.
Preferably R12 is H.
Preferably R13, Ru, R15, R1* are each, independently, H, CH3, C2HS, CF3, CH30, C(0)CH3 or CH3OCH2.
More preferably R13, R14, R1S, R16 are each, independently, H or CH3.
Preferably R17 is H.
Preferably R18 is H, CH3, C2HS, C(0)OCi-4 alkyl (optionally substituted with
halogen or CM alkoxy) or COH.
More preferably R18 is C(0)OCM alkyl (optionally substituted with halogen or
CM alkoxy) or COH,
Even more preferably R18 is C(0)OCM alkyl (optionally substituted with halogen or
CM alkoxy).
Most preferably RIB is C(0)OCM alkyl.
Preferably R19 and R2C are each, independently, H, halogen, Cu alkyl, d-3 alkoxy, CH20, C3.6 cycloalkyl, CH20-C(=0)CH3, CH2-C3-6 cycloalkyl or benzyl; or R19 and R20 together with the carbon atom to which they are attached form a carbonyl group, a 3-5 membered carbocyclic ring, Ci-s alkylidene or C3-6 cycloalkylidene.

More preferably R19 and R20 are, independently, H, CH3, C2H5, H-C3H7,1-C3H7, 1-C+H9, CH(C2H5)2, CHrCyclopropyl or cyclopentyl; or R19 and R20 together with the carbon atom to which they are attached form a 3-membered caibocyclic ring.
Preferably R21 is H or CH3.
Preferably R22 is H or CH3.
Preferably R23 is H or CH3.
Preferably R24 is H or CH3.
Compounds of formula (H):

where R1 and R2 are as defined above for a compound of formula (I) and Y is halogen, hydroxy or Ci .5 alkoxy, are useful as intermediates in the preparation of compounds of formula (I).
Some compounds of formula (II) are already known in the literature [B.Iddon et a!. J.Chem. Soc. PerkinTrans. 7,1341 (1996); M.Eegtrup etal., Acta Chemica Scand., 19, 2022 (1965); D.R.Buckie et al., J. Chem,Res, Syn. 10, 292 (1982); and A.Peratoner et al., ScLFis.Mat.Nal.Rend 5,16 (1907)] but others are novel.
Therefore, in another aspect the present invention provides a compound of formula (H) where R1 and R2 are as defined above for a compound of formula (I) and Y is halogen, hydroxy or CJ.J alkoxy; provided that when R1 is chloro and R2 is 4-CH30-CsH4-CH3-, Y is not C:H50; when R1 is CH30 and R2 is CH3, Y is not C2H5O; when R1 is bromo and R2 is CH3OCH2, Y is not CH30; and when R1 is CH3 and R2 is C3H5, Y is not OH.
Preferably Y is hydroxy, chloro, fluoro orQ.3 alkoxy.
Some compounds of formula (ffla) are also novel but some are described in the literature [see, for example, L. A Paquette et al., J. Amer. Chem Soc. 99, 3734 (1977); H. Plieninger et al., Chem. Ber. 109, 2121 (1976); Kasansski et al., Zh. Obshch.Khim. (1959), 29, 2588; and A. J. Kirby et al., J. Chem. Soc, Perkin Trans. 2, 1997, 1081].

Anilines of formula (Ilia) are novel when R13, R.'\ R15, Rl6f Q and X are as defined above for a compound of formula (I); provided that whenR13, RM, R15 and R16 are each H then X is not CH2 when Q is a double bond and X is not CH2CH2 when Q is a single bond or a double bond; and when R13 is CH3, RH is OCH3 and R1S and R16 are both H then X is not CH2CH2 when Q is a single bond.
Therefore, in a further aspect, the present invention provides a compound of formula (da) where R!3, R14, R15, R16, Q and X are as defined above for a compound of formula (I); provided that when R13, R14, R15 and R16 are each H then X is not CH2 when Q is a double bond and X is not CH2CH2 when Q is a single bond or a double bond; and when R13 is CH3, R14 is OCH3 and Rli and R16 are both H then X is not CHJCHJ when Q is a single bond.
The compounds of formula (I), (II) and (IHa) may exist as different geometric or optical isomers or in different tautomeric forms. This invention covers, for each formula, all such isomers and tautomers and mixtures thereof in all proportions as well as isotopic forms such as deuterated compounds.
The compounds in Tables 1 to 28 below illustrate compounds of the invention.
Table 1 provides 59 compounds of formula (H) wherein R1, R2 and Y are as defined in Table 1.

Table X represents Table 2 [when X is 2], Table 3 [when X is 3], Table 4 [when X is 4], Table 5 [when X is 5], Table 6 [when X is 6] and represents Table 7 [when X is 7].

Table 2 provides 457 compounds of formula (1-2):

wherein R2, R3, R6 and R7 are as defined in Table 2.
Table 3 provides 457 compounds of formula (1-3):

wherein R2, R3, R6 and R7 are as defined in Table 3.
Table 4 provides 457 compounds of formula (1-4):

wherein R3, R3, R6 and R7 are as defined in Table 4.
Table 5 provides 457 compounds of formula (1-5):

wherein R3, R3, R6 and R7 are as defined in Table 5.

Table 6 provides 457 compounds of formula (1-6):

wherein R2, R3, R6 and R7 are as defined in Table 6.
Table 7 provides 457 compounds of formula (1-7):

wherein R2, R3, R6 and R7 are as defined in Table 7.
Table Y represents Table 8 [when Y is 8], Table 9 [when Y is 9], Table 10 [when Y is 10], Table 11 [when Y is 11], Table 12 [when Y is 12], Table 13 [when Y is 13], Table 14 [when Y is 14], Table 15 [when Y is 15], Table 16 [when Y is 16], Table 17 [when Y is 17], Table 18 [when Y is 18] and represents Table 19 [when Y is 19].

Table 8 provides 364 compounds of formula (1-8):

wherein R2, R3,.and R6 are as defined in Table 8.
Table 9 provides 364 compounds of formula (1-9):

wherein R2, R3, and R6 are as defined in Table 9.

Table 10 provides 364 compounds of formula (I-10):

wherein R2, R3, and R6 are as defined in Table 10.
Table 11 provides 364 compounds of formula (1-11):

wherein R2, R3, and R6 are as defined in Table 11.
Table 12 provides 364 compounds of formula (1-12):

wherein R2, R3, and Rfi are as defined in Table 12.
Table 13 provides 364 compounds of formula (1-13):

wherein R2, R3, and R are as defined in Table 13.

Table 14 provides 364 compounds of formula (1-14):

wherein R2, R3, and R6 are as defined in Table 14.
Table 15 provides 354 compounds of formula (1-15):

wherein R2, R3, and R6 are as defined in Table 15.
Table 16 provides 364 compounds of formula (1-16):

wherein R2, R3, and R6 are as defined in Table 16.
Table 17 provides 364 compounds of formula (1-17):

wherein R2, R3, and R* are as defined in Table 17.

Table 18 provides 364 compounds of formula (I-I8):

wherein R2, R3, and R6 are as defined in Table 18.
Table 19 provides 364 compounds of formula (1-19):
wherein R2, R3, and R6 are as defined in Table 19.
Table Z represents Table 20 [when Z is 20], Table 21 [when Z is 21], Table 22 [when Z is 22], Table 23 [when Z is 23], Table 24 [whenZ is 24] and represents Table 25 [when Z is 25].

Table 20 provides 182 compounds of formula (1-20):
wherein R2, R3 and A are as defined in Table 20.
Table 21 provides 182 compounds of formula (1-21):

wherein R2, R3 and A are as defined in Table 21.
Table 22 provides 182 compounds of formula (1-22):

wherein R2, R3 and A are as defined in Table 22.
Table 23 provides 182 compounds of formula (1-23):
wherein R2, R3 and A are as denned in Table 23.

Table 24 provides 182 compounds of formula (1-24):

wherein R2, R3 and A are as defined in Table 24.
Table 25 provides 182 compounds of formula (1-25):

wherein R2, R3 and A are as defined in Table 25.
Table 26 provides 133 compounds of formula (Ula) where R13, Rw, R15, RIS, Q and X are as defined in Table 26. Q is shown to be either a single bond (•) or a double bond (=).

Tabic ZZ represents Table 27 (when ZZ is 27) and represents Table 28 (when ZZ is 28).

Table 27 provides 42 compounds of formula 0-27) where R1, R2, R3 and R6 are as defined in Table 9.
Table 28 provides 42 compounds of formula (1-28) where R1, R2, R3 and R5 are as defined in Table 10.

Throughout this description, temperatures are given in degrees Celsius; "NMR" means nuclear magnetic resonance spectrum; MS stands for mass spectrum; "%" is percent by weight, unless corresponding concentrations are indicated in other units; "syn" refers to a syn configuration of the relevant substituent with respect to the annellated

benzene ring; and "anti" refers to an anti configuration of the relevant substituent with respect to the anellated benzene ring.
The following abbreviations are used throughout this description:
m.p. = melting point b.p.= boiling point,
s = singlet br = broad
d = doublet dd = doublet of doublets
t = triplet q = quartet
m = multiplet ppm = parts per million
Table 29 shows selected melting point data for compounds of Tables 1 to 28.

The compounds according to formula (I) may be prepared according to the following reaction schemes.
fat Preparation of a compound of formula (II).
Schemes 1,2 and 3 demonstrate that a compound of formula E, H, K, L, N, O, P, R,
SjLH-ViiViXOTZ [where R1 and R2 are as defined above for formula (II); and R' is
C].s aikyl] {each of which is a compound of formula (U), as defined above} maybe
prepared by a reaction sequence starting with a 1,2,3-triazole-4,5-dicarboxylic acid diester
of formula A [Y.Tanafca et al., Tetrahedron, 29,3271 (1973)] [where each R' is,
independently, Ci-5 alkyl] (preferably the dimethyl ester).
Scheme 1

Treatment of A with an alkylating agent [such as R2-halo (where R2 is as defined above for formula (II); and halo is preferably iodo) or an appropriate sulphate, sulphonate or carbonate ester] in the presence of a base [such as K2CO3, Na2C03 or NEt3] in a suitable solvent [such as acetonitrile, DMF or dimethylacetamide] at ambient to elevated temperatures furnishes a mixture of regioisomers, of formulae B and C, which may be separated by conventional methods. Saponification of a compound of formula B with up to one equivalent of a base [such as KOH, NaOH or LiOH] in a protic solvent [such as methanol], preferably under reflux conditions, provides a mono-ester of formula D. Subsequent reaction of a compound of formula D with a fmorinating agent [such as DAST (diethylamino sulphur trifloride) or, preferably, SF4] in the presence of hydrofluoric acid gives a 5-CF3-l,2,3-triazole-4-carboxylic acid ester of formula E.

Alternatively, treatment of a compound of formula D with a chlorinating agent [such as thionyl chloride or phosgene] under standard conditions results in an acid chloride of formula F which may be reduced catalytically in an inert solvent [for example ethyl acetate or THF] in the presence of a base [for example Htinig base] to give an aldehyde-ester of formula G (modified Rosenmund conditions). Fluorination of a compound of formula G_ by means of DAST, dimethoxy-DAST or SFt in the presence of hydrofluoric acid, optionally with solvent, preferably at elevated temperatures, forms a 5-difluoromethy3-l,2,3-triazole-4-carboxylic acid ester of formula H.
Metal hydride reduction of a compound of formula G [for example by NaBHi or LiBHfl] in methanol provides a 5-hydroxymethyI-l ,2,3-triazole of formula J, from which a 5-fluoromethyl derivative of formula K may be obtained by fluorination under mild conditions, preferably with DAST at low temperatures (0 to -78°C) in an inert solvent [such as dichloromethane].
Alternatively, hydride reduction of a compound of formula J by conventional methods [for example via its mesylate, tosylate or iodide] results in a 5-methyl-1,2,3-triazole of formula L.
Chlorination of compound of formula D [for example by thionyl chloride] followed by treatment with ammonia, preferably in a protic solvent [such as water, methanol or ethanol] furnishes an amide of formula M from which a 5-cyano-l ,2,3-triazole of formula N may be obtained by means of a dehydrating agent [such as phosphorylchloride].

Further transformations to prepare a compound of formula (TJ) [where R1 and R2 are as defined above for formula (I); Y is OR' and R' is Q.s alkyl] include iHofinann rearrangement of an amide of formula M with NaOBr or NaOCl in the presence of NaOH to give a 5-amino-l,2,3-triazole of formula O.
Diazotation of a compound of formula O by means of sodium nitrite under aqueous acidic conditions [for example sulphuric acid] or with a nitrite ester [for example (0-amyl nitrite] in an organic solvent [for example acetone, dichloromethane or THF] in the presence of a halogenide [such as CuCl or CuBr] gives a 5-halo-l,2,3-triazole of formula P [where halo is CI or Br] which on treatment with a fluorinating agent [such as KFor CsF], preferably in DMF orN-methylpyrrolidone at elevated temperatures, results in a S-fluoro-lAS-triazole of formula V.
By diazotation of a compound of formula O and subsequent acidic aqueous hydrolysis under heating, a 5-hydroxy-l ,2,3-triazole of formula Q may be obtained. Treatment of a compound of formula 0_ with an alkylating agent [such as methyl iodide, dimethylsulphate or dimethylcarbonate] and a base [for example NaH, K2COj or Na3C03] in a polar solvent [for example DMF, DMSO or CH3CN] gives a 5-methoxy-l,2,3-triazole of formula R which may be converted to a tricbloromethoxy derivative of formula S with a chlorinating agent [such as chlorine] in the presence of azoisobutyronitrile (AJBN) or ultra-violet irradiation at elevated temperature. By treatment of a compound of formula S with a fluorinating agent [for example KF or SbF3] a 5-trifluoromethoxy~l,2,3-triazole of formula T may be prepared.

Oxidation of a compound of formula O with {for example sodium perborate] or treatment according to A. Sudalai et al. [ Angew. Chem. Int. Ed. 40,405 (2001)] leads to a 5-nitro derivative of formula U. Alternatively, a compound of formula U may also be obtained by treatment of a compound of formula P or V with NaNO; in an polar solvent [such as DMF, sulpholane or N-methylpyrrolidone] at elevated temperatures.

Transformations of a compound of formula (II') [where R1 and R2 are as defined in ' formula (I); Y is OR'; andR' is Ci-salkyl] to give a compound of formula (II) [where Rl and R1 are as defined in formula (I) and Y is halo or hydroxy] includes saponification with a base [such as KOH or NaOH] in a protic solvent [such as methanol, ethanol or water], at ambient or elevated temperature to give a l,2,3-triazole-4-carboxylic acid of formula W. Chlorination of a compound of formula W under standard conditions [for example with thionyl chloride, phosgene or oxaly] chloride] yields an acid chloride of formula Y.
Fluorination of a compound of formula W with DAST or SF4 under mild conditions [low to ambient temperatures], preferably in an inert solvent [such as dichloromethane] gives an acid fluoride of formula Z.
fb) Preparation of a compound of formula fllli.
A compound of formula (IDQ
H2N-A (111)
where A is as defined above for a compound of formula (I), is useful as an intermediate in the preparation of a compound of formula (I).

Most o-substituted amino-aryls and amino-heteroaryls of formula 0H) are known from the literature, but some are novel.
A compound of formula (tQa) may be obtained according to scheme 4:

Treatment of an ortAo-substituted nitrobenzonorbomadiene of formula AA (where R13, RM, R15, R16 and X are as defined above for a compound of formula (I)) [obtained through Diels-Alder addition of an in situ generated benzyne, for example, starting from a 6-nitroanthranilic acid as described by L.Paquette et al, J. Amer. Chem. Soc. 99, 3734 (1977) or from other suitable benzyne precursers (see H. PeUissier et al. Tetrahedron, 59, 701 (2003) with a 5-7 membered cyclic 1,4-diene according to, or by analogy to, L.Paquette et al, J. Amer. Chem. Soc. 99, 3734 (1977), D. Gravel et al. Can. J. Chem. 69, 1193 (1991), J.R. Malpass et al. Tetrahedron, 48, 861 (1992), D.E. Lewis et al. Synthetic Communications, 23, 993 (1993), R.N. Warrener et al. Molecules, 6, 353 (2001), R.N. Warrener et al. Molecules, 6,194 (2001) or I. Fleming et al. /. Chem. Soc, Perkin Trans. J, 2645 (1998)] with Zn, in the presence of ammonium chloride or an aluminium amalgam, in a protic solvent [such ethanol or water] gives an aniline of formula CC, whilst catalytic hydrogenation of a compound of formula A4 with, for example, RaNi, Pd/C or Rh/C in the presence of a solvent [for example TKF, ethyl acetate, methanol or ethanol] affords an aniline of formula BB. Compounds of formula (fllb)

where R is an aliphatic or alicyclic, saturated or unsaturated group [in which the group contains three to thirteen carbon atoms and at least one silicon atom and, optionally, one to three heteroatoms, each independently selected from oxygen, nitrogen and sulphur, and the group is optionally substituted by up to four independently selected halogen atoms] and R7"10 are as defined in formula (I) may be prepared by analogy with literature examples. References include e.g. E.A.Chernyshew et al., Bull. Acad. Sci. USSR ,1960, 1323; K.T.Kang et al., Tetrahedron Utters, 32, 4341 (1991), Synthetic Comm., 24,1507 (1994); MMurata et al., Tetrahedron Letters 40, 9255 (1999); A.Falcou et al., Tetrahedron 56, 225 (2000); A.Arcadi et al., Tetrahedron Letters 27, 6397 (1986); K.C.Nicolaou et al., Chem.Eur. J. 1, 318 (1995); N.Chatani et al., J.Org. Chem. 60, 834 (1995); T. Stuedemann et al,, Tetrahedron 54, 1299 (1998); P.RHurdlik et al., J. Org. Chem. 54, 5613 (1989); K.Karabelas et al., J. Org. Chem. 51, 5286 (1986); TJeffery, Tetrahedron Letters 40, 1673 (1999) and Tetrahedron Letters 41, S445 (2000); K.01ofson et al., J. Org. Chem. 63, 5076 (1998); H.Uirata et al., Bull. Chem. Soc. Jap. 57, 607 (1984); and G.Maas et al., Tetrahedron 49, 881 (1983); and references cited therein.
Recent reviews for the introduction of Si-containing functionalities into phenyl derivatives can be found in "The Chemistry of Organosilicon Compounds", Vols. 1 -3, S.Patai, Z.Rappaport and Z.Rappaport, Y-Apeloid eds., "Wiley 1989, 1998, 2001 and "Houben-Weyl Science and Synthesis", Organometallics Vol. 4, LFleming ed., G.Thieme 2002.
Another group of anilines comprises compounds of formula (Die)

where R! represents C2-i alkyl, C2.4 haloalkyl or C3-6 cycloalkyl (itself optionally substituted by up to 3 substituents, independently selected from halo, Q.j alkyl, Cu haloalkyl and CM haloalkoxy).
A compound of formula (Hie) may be prepared by a reaction sequence starting with a crossed aldol condensation of benzaldehyde with a ketone of formula CHiCfCOR' . [where R' is as defined above for a compound of formula (IHc)] in the presence of NaOH

or KOH in a solvent (such as water or ethanol) and usually under reflux conditions or alternatively by reaction of benzaldehyde with a Wittig reagent under standard conditions. The resulting a,p-unsaturated ketone of formula (IV) [where R' is as defined above for a compound (Die)]:

may then be converted into a compound of formula (V) [where R' is as defined above for a compound (Hie)]:

by reacting first with hydrazine hydrate in ethanol under reflux conditions and then heating (in the range of from 150 to 250°C) in the presence of KOH (distilling off the solvent). After nitration with HNO3-H2O or HNOj-acetic anhydride in a cooled vessel (in the range of from -30°C to 0°C), the resulting o/p-mixture of a nitrobenzene of formula (VI) [where R' is as defined above for a compound (IHc)J:

may then be separated and catalytically reduced (Pt/C/ H2 or Ra-Ni/H2) in a solvent (such as methanol, ethanol of THF) at ambient temperature to give a compound of formula
(inc).
Alternatively the synthesis of a compound of formula (Hid) [where R'a is hydrogen or methyl]

may be accomplished by a reaction sequence started by a Wittig reaction of o-nitrobenzaldehyde with an ylide, prepared from a
cyclopropylmethyltriphenylphosphonium bromide in the presence of a strong base [such as NaH] in a solvent [such as DMSO], in the range of 0-S5"C. The resulting E/Z-mixtuie of a compound of formula (YD)

by the application of the Simmons Smith reaction (Zn-Cu, CH2I2, ether as a solvent) to the olefin group of a compound of formula (YD) to give a compound of formula (VET). The reduction of the nitro moiety of a compound of formula (VIH) to give a compound of formula (Die) may be performed by using the same conditions as described above for a compound of formula (VI). fc) Preparation of a compound of formula (I).
Schemes

A compound of formula (I) £ where A, R1 and R2 are as defined above and R3 is H] may be synthesized by reacting a compound of formula (IT) [where R1 and R2 are as defined above and R' is C1-5 allcyl] with an aniline of formula (12) [where A is as defined above for a compound of formula (I)] in the presence of NaN(TMS)2 at -10 DC to ambient temperature, preferably in. dry THF, as described by J.Wang et al., Synlett, 2001, 1485,

Alternatively, a compound of formula (I) [where A, R1 and R2 are as defined above and R3 is H] may be prepared by reacting a compound of formula (D) [where R1 and R2 are as defined above and Y is OH] with a compound of formula (TH) [where A is as defined above for a compound of formula (I)] in the presence of an activating agent [such as BOP-C1] and two equivalents of a base [such as NEt3] or by reacting a compound of formula (II) [where Y is CI, Br or F] with a compound of formula (IE) in the presence of one equivalent of a base [such as NEt3, NaHCOj, KHCO3, Na2C03 or K2C03] in a solvent [such as dichloromethane, ethyl acetate or DMF] preferably at -10 to 30°C.
Scheme 7

A compound of formula (I) [where R3 is as defined above for formula (J), except that it is not hydrogen] may be prepared by reacting a compound of formula (I) [where R3 is hydrogen] with a species Y-R3 [where R3 is as defined for formula (I), except that it is not hydrogen; and Y is halogen, preferably CI, Br or I; or Y is such that Y-R3 is an anhydride: that is, when R3 is COR*, Y is OCOR*] in the presence of a base [for example NaH, NEt3, NaHCOj or K2CO3] in an appropriate solvent [such as ethyl acetate] or in a biphasic mixture [such as dichtoromethane/water mixturte], at-10 to 30DC.
Surprisingly, il has now been found that the novel compounds of formula (I) have, for practical purposes, a very advantageous spectrum of activities for protecting plants against diseases that are caused by fungi as well as by bacteria and viruses.
The compounds of formula (I) can be used in the agricultural sector and related fields of use as active ingredients for controlling plant pests. The novel compounds are distinguished by excellent activity at low rates of application, by being well tolerated by'

plants and by being environmentally safe. They have very useful curative, preventive and systemic properties and are used for protecting numerous cultivated plants. The compounds of formula I can be used to inhibit or destroy the pests that occur on plants or parts of plants (fruit, blossoms, leaves, stems, tubers, roots) of different crops of useful plants, while at the same time protecting also those parts of the plants that grow later, for example from phytopathogenic microorganisms.
It is also possible to use compounds of formula (I) as dressing agents for the treatment of plant propagation material, in particular of seeds (fruit, tubers, grains) and plant cuttings (e.g. rice), for the protection against fungal infections as well as against phytopathogenic fungi occurring in the soil.
Furthermore the compounds according to present invention may be used for controlling fungi in related areas, for example in the protection of technical materials, including wood and wood related technical products, in food storage, in hygiene management, etc.
The compounds of formula (I) are, for example, effective against the phytopathogenic fungi of the following classes: Fungi imperfecta' (e.g. Botrytis, Pyricularia, Helminthosporium, Fusarium, Septoria, Cercospora and Altemaria) and Basidiomycetes (e.g. Rhizoctonia, Hemileia, Puccinia). Additionally, they are also effective against the Ascomycetes classes (e.g. Venturia and Erysiphe, Podosphaera, Monilinia, Uncinula) and of the Oomycetes classes (e.g. Phytophthora, Pythium, Plasmopara). Outstanding activity has been observed against powdery mildew (Erysiphe spp.). Furthermore, the novel compounds of formula I are effective against phytopathogenic bacteria and viruses (e.g. against Xanthomonas spp, Pseudomonas spp, Erwinia amylovora as well as against the tobacco mosaic virus).
Within the scope of present invention, target crops to be protected typically comprise the following species of plants: cereal (wheat, barley, rye, oat, rice, maize, sorghum and related species); beet (sugar beet and fodder beet); pomes, drupes and soft fruit (apples, pears, plums, peaches, almonds, cherries, strawberries, raspberries and blackberries); leguminous plants (beans, lentils, peas, soybeans); oil plants (rape, mustard, poppy, olives, sunflowers, coconut, castor oil plants, cocoa beans, groundnuts); cucumber plants (pumpkins, cucumbers, melons); fibre plants (cotton, flax, hemp, jute); citrus fruit (oranges, lemons, grapefruit, mandarins); vegetables (spinach, lettuce, asparagus,

cabbages, carrots, onions, tomatoes, potatoes, paprika); lauraceae (avocado, cinnamomum, camphor) or plants such as tobacco, nuts, coffee, eggplants, sugar cane, tea, pepper, vines, hops, bananas and natural rubber plants, as well as ornamentals.
The compounds of formula (I) are used in unmodified form or, preferably, together with the adjuvants conventionally employed in the art of formulation. To this end they are conveniently formulated in known manner to emulsifiable concentrates, eoatable pastes, directly sprayable or dilutable solutions, dilute emulsions, wettable powders, soluble powders, dusts, granulates, and also encapsulations e.g. in polymeric substances. As with the type of the compositions, the methods of application, such as spraying, atomising, dusting, scattering, coating or pouring, are chosen in accordance with the intended objectives and the prevailing circumstances. The compositions may also contain .further adjuvants such as stabilizers, antifoams, viscosity regulators, binders or tackifiers as well as fertilizers, micronutrient donors or other formulations for obtaining special effects.
Suitable carriers and adjuvants can be solid or liquid and are substances useful in formulation technology, e.g. natural or regenerated mineral substances, solvents, dispersants, wetting agents, tackifiers, thickeners, binders or fertilizers. Such carriers are for example described in WO97/33890.
The compounds of formula (I) are normally used in the form of compositions and can be applied to the crop area or plant to be treated, simultaneously or in succession with further compounds. These further compounds can be e.g. fertilizers or micronutrient donors or other preparations which influence the growth of plants. They can also be selective herbicides as well as insecticides, fungicides, bactericides, nematicides, molluscicides or mixtures of several of these preparations, if desired together with further carriers, surfactants or application promoting adjuvants customarily employed in the art of formulation.
The compounds of formula (1) can be mixed with other fungicides, resulting in some cases in unexpected synergistic activities. Mixing components which are particularly preferred are azoles, such as azaconazole, BAY 14120, bitertano!, bromuconazole, cyproconazole, difenoconazole, diniconazole, epoxiconazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, hexaconazole, imazalil, imiben-conazole, ipconazole, metconazole, myclobutanil, pefurazoate, penconazole, pyrifenox, prochloraz, propiconazole, simeconazole, iebuconazole, tetraconazole, triadimefon.

triadimenol, triflumizole, triticonazole; pyrimidinyl carbinole, such as ancymidol, fenarimol, nuarimol; 2-ambo-pyrirnidraes, such as bupirimate, dimethirimol, ethirimol; moipholines, such as dodemorph, fenpropidine, fenpropimorph, spiroxamine, tridemorph; anilraopyrirnidines, such as cyprodinil, mepanipyrim, pyrimethanil; pyrroles, such as fenpiclonil, fludioxonil; phenylamides, such as benalaxyl, furalaxyl, metalaxyl, R-metalaxyl, ofurace, oxadixyl; benzimidazoles, such as benomyl, carbendazim', debacarb, Albendazole, thiabendazole; dicarboximides, such as chlozolinate, dichlozoline, iprodione, myclozoline, procymidone, vinclozoline; carboxamides, such as carboxin, fenfurara, flutolanil, mepronil, oxycarboxin, thifluzaraide; guanidines, such as guazatine, dodine, iminoctadine; strobilurines, such as azoxystrobin, kresoxim-methyl, metomi-nostrobin, SSF-129, trifloxystrobin, picoxystrobin, BAS 500F proposed name pyraclostrobin), BAS 520; dithiocarbamates, such as ferbam, mancozeb, maneb, metiram, propineb, thiram, zineb, ziram; N-halomethylthiotetrahydrophthalimides, such as captafol, captan, dichlofluanid, fluoromides, folpet, tolyfluanid; Cu-compounds, such as Bordeaux mixture, copper hydroxide, copper oxychloride, copper sulfate, cuprous oxide, mancopper, oxine-copper; nitrophenol-derivatives, such as dinocap, nitrothal-isopropyl; organo-p-derivatives, such as ediferiphos, iprobenphos, isoprothiolane, phosdiphen, pyrazophos, tolclofos-methyl; various others, such as acibenzolar-S-methyl, anilazine, benthiavalicarb, blasticidin-S, chinomethionate, chloroneb, chlorothalonil, cyflufenamid, cyrnoxanil, dichlone, diclomezine, dicloran, diethofencarb, dimethomorph, SYP-LI90 (proposed name: flumorph), dithianon, ethaboxam, etridiazole, famoxadone, fenamidone, fenoxanil, fentin, ferimzone, fluazinam, Ousulfamide, fenhexamid, fosetyl-aluminium, hymexazol, iprovalicarb, DCF-916 (cyazofamid), kasugamycin, methasulfocarb, metrafenone, nicobifen, pencycuron, phthalide, polyoxins, probenazole, propamocarb, pyroquilon, quinoxyfen, quintozene, sulrbr, triazoxide, tricyclazole, triforine, validamycin, zoxamide (RH7281).
A preferred method of applying a compound of formula (I), or an agrochemical composition which contains at least one of said compounds, is foliar application. The frequency of application and the rate of application will depend on the risk of infestation by the corresponding pathogen. However, the compounds of formula I can also penetrate the plant through the roots via the soil (systemic action) by drenching the locus of the plant with a liquid formulation, or by applying the compounds in solid form to the soil,

e.g. in granular form (soil application). In crops of water rice such granulates can be applied to the flooded rice field. The compounds of formula I may also be applied to seeds (coating) by impregnating the seeds or tubers either with a liquid formulation of the fungicide or coating them with a solid formulation.
A formulation [that is, a composition containing the compound of formula (I)] and, if desired, a solid or liquid adjuvant, is prepared in a known manner, typically by intimately mixing and/or grinding the compound with extenders, for example solvents, solid carriers and, optionally, surface active compounds (surfactants).
The agrochemical formulations will usually contain from 0.1 to 99% by weight, preferably from 0.1 to 95% byweight, of the compound of formula I, 99.9 to l%by weight, preferably 99.8 to 5% by weight, of a solid or liquid adjuvant, and from 0 to 25% by weight, preferably from 0.1 to 25% by weight, of a surfactant.
Advantageous rates of application are normally from 5g to 2kg of active ingredient (a.i.) per hectare (ha), preferably from lOg to 1kg a.i./ha, most preferably from 20g to 600g a.i./ha. When used as seed drenching agent, convenient dosages are from lOmg to lg of active substance per kg of seeds.
Whereas it is preferred to formulate commercial products as concentrates, the end user will normally use dilute formulations.
The following non-limiting Examples illustrate the above-described invention in more detail.
EXAMPLE 1 This Example illustrates the preparation of Compound No. 1.15 [2-methyl-5-trifluoromethyl-2H-l,2,3-triazole-4-carboxylic acid methyl ester] and Compound No. 1.13 [2-methyl-5-trifluoromethyl-2H-l,2,3-triazole-4-carboxylicacid]. al Preparation of 2-methvt-2H-L2,3-triazole-4.5-dicarboxvlic acid dimethvlester and l-methvl-lH-1.2.3-triazoIe-4.5-dicarboxvlic acid dimethylester.
l,2,3-Triazole-4,5-dicarboxylic acid dimethyl ester (Y. Tanaka et al. Tetrahedron 29, 3271 (1973)) (74.06g; 0.40mol), potassium carbonate (110.57g; O.SOmol) and methyl iodide (73.81g; 0.52mol) were reacted in acetonitrile (1000ml) at 40°C for 20minutes and then for 20hours at ambient temperature. The mixture was poured onto ice-water and extracted with ether to give the crude product (70.66g) as a mixture of isomers. Separation on silica gel in ethyl acetate-hexane (2:3) yielded 36.51g (46%) of 2-methyl-

2H-l,2,3-triazole~4,5-dicarboxylic acid dimethylester [m.p. 86-87°C; 'H-NMR (300 MHz, DMSO-de), S(ppm): 4.27(s,3H), 3.88(s,6H)] and 26.92g (34%) qf 1-methyl-1H-1,2,3-triazole-4,5-dicarboxylic dimethylester [m.p. 63-64°C; 'H-NMR (300MHZ, DMSO-ds), 5(ppm): 4.19(s,3H), 3.93(s,3H), 3.87(s,3H)J. b) Preparation of 2-roethvl-2H-l,213-triazole-4.5-dicarboxvlic acid roonomethvl ester
To a solution of 2-methyl-2H-l,2,3-triazole-4,5-dicarboxylic acid dimethylester (1.2g;6mmol)in30mlmethanolwasadded358mgKOH(assay 86%; 5.5mmol). The mixture was heated at reflux temperature for 48hours. The solvent was evaporated and the residue was then taken into water and extracted with ethyl acetate (3 times). The combined organic phases contained non-reacted starting material. The aqueous phase was acidified with 2N HC1 (pH2-3) and extracted with ethyl acetate (3 times). The extracts were combined, dried (anhydrous MgS04) and evaporated to dryness to give 803mg (72%) of the desired compound (m.p. 125-126°C; 'H-NMR (300 MHz, DMSO-d6), 8(ppm): 13.7(br.s,lH, exchangable withD20), 4.24(s,3H), 3.84(s,3H). cl Preparation of 2-methvl-5-trifluoromethyl-2H-1.23-triazole-4-carboxvlic acid methyl ester [Compound Number 1.151.
2-Methyl-2H-l,2,3-triazole-4,5-dicarboxylic acid monomethyl ester (2.9g; 15.66mmol) and dichloromethane (160ml) were placed in an 0.31itre monel autoclave. Under an inert atmosphere and cooling with dry ice, gaseous HF (27g) was introduced at -50°C followed by gaseous SF4 (distilled, 6.9g; 64.23mmol). The autoclave was heated to 80°C for 6houra. The maximum pressure amounted 9.8bar. After cooling to ambient temperature the reaction mixture was poured onto ice-dichloromethane and adjusted to pH7 with aqueous NaHCOa. Extraction with dichloromethane (3 times), drying over Na2S04 and evaporation under reduced pressure afforded the crude product. Purification by Kugelrohr-distillation at 3mbar and ca.l80°C gave 2.8g (85%) of Compound No.l .15 as a yellowish liquid.
'H-NMR (300 MHz, CDCU), 5(ppm): 4.29(s,3H), 3.97(s,3H);
,9F-NMR (235 MHz, CDClj), 5 (ppm): -61.7.
,3C-NMR(125MHz,CDCl3),6(ppm): 159.05,139.65(^^^ = 40.8 Hz), 137.20, 119.63 (q, 3CF = 269.4 Hz, CF3), 52.96, 43.01.

dl Preparation of 2-methvl-5-trifluoromethvl-2H-l,2,3-triazole-4-carboxylic acid rCompound Number1.131
A solution of 2-methyl-5-trifluoromethyl-2H-l,2,3-triazole-4-carboxyIic acid methyl ester [Compound Number 1.15] (2.09g; O.Olmol) and KOH (86 %; 0.783g; 1.2eq.) in THF (50ml) was heated at reflux temperature for 3.5 hours. The solution was evaporated, the residue was dissolved in water and acidified to pH 1-2 with HC1 (1M). Evaporation of the aqueous solution followed by continuous extration in ethylacetate for 20 hours gave of Compound No 1.13 (2.1 Ig; 100%) as a crystalline solid.
'H-NMR (400 MHz, DMSO-d6), 5(ppm): 4.19(s,3H).
I9F-NMR (235 MHz, DMSO-d6), 6 (ppm): -59.3,
l3C-NMR (125 MHz, DMSO-d6), fifppm): 160.74, 144.08, 135.81 (q, Jc EXAMPLE 2
This Example illustrates the preparation of Compound No. 1.03 [2-methyl-5-difluoromethyl-2H-l,2,3-triazole-5-carboxylic acid methyl ester].
a) Preparation of 5-Chlorocarbonvl-2-methvl-2H-1.2.3-triazole-4-carboxylic acid methyl
ester.
Methyl 2-methyl-I,2,3-triazole-4,5-dicarboxylate (2.3g; O.Ollmol) was reacted withoxalyl chloride (1.46ml; 0.014mol)plus two drops ofDMFmdichlorornethane (20ml) at 20°C. When the vigourous reaction ceased the temperature was raised to reflux for 15hours. The mixture was evaporated to dryness to give 2.7g of the acid chloride as a solid. 'H-NMR (300 MHz, CDC13), 5 (ppm): 4.48(s, H), 4.0(s,3H).
b) Preparation of 5-fonnvl-2-methvl-2H-l,2.3-triazole-4-carboxvlic acid methyj ester.
To a solution of freshly prepared 5-ChlorocarbonyI-2-methyl-2H-l,2,3-triazole-4-carboxylic acid methyl ester (2.7g; ca. 13mmoi) in THF (270 m!) was added ethyl-diisopropyl-amine(1.88g; l.leq.). The mixture was hydrogenated in the presence of 2.7g 10% Pd/C at 0-5°C at normal pressure for 2'/2 hours and subsequently filtered from the catalyst. The clear solution was evaporated to give the crude as a solid which was dissolved again in ethyl acetate and stirred for a couple of minutes with silica gel. After filtration and evaporation 1.77 g (84%) of pure product as off-white crystals were obtained [m.p. 107-108°C; 'H-NMR (300 MHz, CDC13), 5 (ppm): 10.43(s,lH), 4.33(s,3H),4.01(s,3H)].

cl Preparation of 2-methvl-5-difluoromethyl-2H-l,2.3-triazole-5-carboxylic acid methyl ester. [Compound No.1.03.]
5-Formy]-2-methyI-2H-l,2,3-triazole-4-carboxylic acid methyl ester (600mg; 3.5mmoI) in 0.5ml CHCU were reacted with (bis(2-methoxyethyl)amino) sulfurtrifluoride (1350mg;6.1mmol)3t ambient temperature to 50°C for 6days. The resulting orange solution was carefully quenched with 6m! of a saturated aqueous NaHCOj solution (vigorous reaction) and extracted with ethyl acetate (twice). The combined organic phases were washed with aqueous NaHCCvsolution, dried over anhydrous MgS04 and evaporated to give 351mg (52%) of colourless crystals.
'H-NMR (300MHZ, CDC13), 5 (ppm): 7.15(t, JHF = 53.5 Hz, 1H, H-CF2), 4.30(s,3H), 3.98(s,3H); ^F-NMR (235 MHz, CDCI3), 5 (ppm): -116.1; ,3C-NMR (125MHz,CDCb), S (ppm): 160.0,143.6 EXAMPLE3
This Example illustrates the preparation of Compound No.l .50 [2-methyI-5-fluorornethyl-2H-l,2,3-triazole-5-carboxylic acid methyl ester].
al Preparation of 5-hvdroxvmethvl-2-methyl-2H-l,2,3-triazole-4-carboxylic acid methyl ester.
2.6g (13.3mmol) of 5-formyl-2-methyl-2H-l,2,3-triazole-4-carboxylic acid methyl ester (see Example 2a) in methanol (100ml) was treated with NaBH4 (601mg) under stirring for lhour at ambient temperature. The reaction mixture was quenched with saturated aqueous ammonium chloride solution, extracted with ethyl acetate, dried with Na2S04 and evaporated to give the crude as an oil. Purification on silica gel in ethyl acetate : hexane (2:1) yielded 1.85g (81%) of the crystalline product,m.p. 112-113°C.
'H-NMR (300MHZ, CDC13), 5 (ppm): 4.86(d, J= 6.9 Hz, 1H), 4.22(s,3H), 3.98(s,3H), 3.53(t; /- 6.9 Hz, exchangeable with D20).
bl Preparation of 2-methvl-5-fluoromethyl-2H-l,2,3-triazole-5-carboxylic acid methyl ester. [CompoundNo.1.50.]
A solution of 5-hydroxymethyl-2-methyl-2H-l,2,3-triazole-4-carboxylic acid methyl ester (200mg; 1.Immol) in CHjCb (15ml) was reacted with 0.26ml diethylamino sulfurtrifluoride (2mmol) for ISminutes at-40°C followed by 15hours at ambient

temperature. After evaporation, the crude product was purified on silica gel in ethyl acetate : hexane (3:1) to give lSlmg (95%) of the desired product, m.p. 64-66°C.
'H-NMR (300MHZ, CDC13), 5 (ppm): 5.66(d, JHF - 47.5 Hz, 2H, Hj-CF), 4.26(s,3H), 3.96(s,3H).
19F-NMR (235 MHz, CDCI3), 5 (ppm): -214.
!3C-NMR (125MHz, CDCb), 5 (ppm): 161.6, 145.86 (&,JC(5>F~ 18.7 Hz) , 137.09, 74.82(d,/cF= 166.6 Hz, CH2F), 52.2,42.3.
EXAMPLE 4
This Example illustrates the preparation of Compound No.3.017 [5-difluoromethyl-2-methyl-2H-1,2,3-triazole-4-carboxylic acid (4'-chloro-biphenyl-2-yl}-amidej.
To a solution of 2-methyl-5-difJuoromethy]-2H-l,2,3-triazoIe-5-carboxylic acid methyl ester (300mg; 1.57mmoI) and 4'-chIoro-bipb.enyl-2-ylamine (320mg; 1.57mmol) in THF (3ml) was added sodium bis(trimethylsilyl)-amide (0.88ml 2M in THF; 1.76mmoI; 1.12eq.) by syringe at 0°C over 1,5minutes. The reaction mixture was stirred at 0°C for 15minutes and then at ambient temperature for 22 hours. It was then poured on cold saturated NH4CI solution and extracted with ethyl acetate. After washing with brine it was dried (anhydrous MgSCv) and evaporated to dryness to give a solid, which was triturated with hexane. The colourless crystalline product was filtered and dried: 300rag (53%) [m.p. 155-156°C; 1H-NMR (300MHz, CDCIj), 5 (ppm): 8.5(br, exchangeable with D20,1H), 8.4 (d, 1H), 7.5-7.2(m,7H), 7.38 {UJHF™ 52.5 Hz,lH, CHF2), 4.2(s,3H), LC-MS:363(M+H)].
EXAMPLE 5
This Example illustrates the preparation of Compound No.2.219 [2-methyl-5-trifluoromethyl-2H-l,2,3-triazole-4-carboxylicacid [2-(l,3-dimethyl-butyl)-phenyl]-amide].
To a solution of 2-methyl-5-trifluoromethyl-2H-1,2,3-triazole-4-carboxylic acid methyl ester (150mg; 0.75mmol) and2-(l,3-dimethyl-butyl)-phenylainiiie (133mg; O.75mmol) in 1.5ml THF was added sodium bis(trimethylsilyl>amide (0.638ml 2M in THF; 1.7eq.) by syringe at ambient temperature. The reaction mixture was stirred for 20hours and was then poured on cold saturated NH4CI solution and extracted with ethyl

acetate. After washing with brine it was dried (anhydrous MgSO-O and evaporated to dryness to give the crude product, which was purified on silica gel in cyclohexane-ethyl acetate (18:1) The crystalline product was triturated in hexane, filtered and dried in vacuo to yield 130mg (49%) of Compound No. 2.219 [mp 94.6-95 A°C; 1H-NMR (300MHz} CDCtj), 8 (ppm); 8.5(br.s, exchangeable with D20,1H), 8.0(d,lH), 7.3-7.15(m,3H), 4.33(s,3H), 3.0(m,lH), L55-l,35(m,3H), 1.26(d,3H), 0.9(2d,6H); LC-MS: 355.6{M+H)].
EXAMPLE 6 This Example illustrates the preparation of Compound No.26.014 [1,8-Dimethyl-1 ] -oxa-tricyclo[6.2. J .0*2.7*]undeca-2,4,6-trien-3-yI-amine].
A solution of l,4-dimethyl-5-nitro-l,4-dihydro-l,4-epoxynaphthalene(5.49g; 25.27mmol) (see T. Nishiyama et aL, Rikagaku-hen, 28, 37-43 (2000)) in 55ml THF was hydrogenated in the presence of RaNi (l.lg) at ambient temparature. Hydrogen uptake was2.231itre(97%) after 18hours. After filtering off the catalyst, the filtrate was evaporated and taken into ether, washed with aqueous NaHCOrsoIution and dried (NaSO.0to give 4.60g of crude product, as an oil. Trituration with hexane and a trace of ether furnished a total of 4.5g (94%) of reddish crystalline product, m.p.92-93°C.
'H-NMR(300MHz, CDC13), 6 (ppm): 7.05(t,lH), 6.7(t,2H), ca.5(br.,exchangeablewithD2O,2H),2.0(s,3H),1.9(m,2H), 1.8(s,3H), 1.7(m,lH), I.S(m,IH).
EXAMPLE 7
This Example illustrates the preparation of Compound No.26.001 [] ,8-DimethyJ-ll-oxa-tricyclo[6.2.1.0*2.7*]undeca-2,4,6,9-tetraen-3-yl-aniine].
To l,4-dimethyl-5-nitro-l,4-dihydro-l,4-epoxynaphthalene (4.22g; 19.43mmol) (see Example 6) in ethanol (60ml) was added a solution of amrnoniumchloride (2.08g) in H2O (5.2ml) at 47°C. Under vigorous stirring, zinc powder (9.10g; 0.14mol) was added in portions over a period of 5minutes. The suspension was heated to reflux for 5'/ihours followed by filtration through Hyflo to give a clear yellow filtrate. After evaporation, the crude product amounted 4.57g, as a viscous oil. Column chromatography on silica gel in ethyl acetate-hexane (1:4) gave 1.24g (34%) of the desired product, as brownish crystals, m.p. 92-96DC.

'H-NMR (300 MHz, CDCb), 5(ppm): 6.85 and 6.7(two m, 2x2H), 6.47 FORMULATION EXAMPLES FOR COMPOUNDS OF FORMULA O)
Working procedures for preparing formulations of the compounds of formula I such as Emulsifiable Concentrates, Solutions, Granules, Dusts and Wettable Powders are described in WO97/33890.
BIOLOGICAL EXAMPLES: FUNGICIDAL ACTIONS
Example B-1: Action against Puccinia recondita / wheat (Brownrust on wheat)
1 week old wheat plants cv. Arina are treated with the formulated test compound (0.02% active ingredient) in a spray chamber. One day after application, the wheat plants are inoculated by spraying a spore suspension (lxl05uredospores/ml) on the test plants. After an incubation period of 2 days at 20°C and 95%r.h. the plants are kept in a greenhouse for 8days at 20CC and 60%r.h. The disease incidence is assessed 1 Odays after inoculation.
Infestation is prevented virtually completely (0-5% infestation) with each of Compounds 2.273, 3.219, 3.273, 3.321, 8.189,9.189, 20.017, 20.022, 21.017 and 21.022. Example B-2: Action against Podosphaera leucotricha / apple fPowdervmildew on apple)
5 week old apple seedlings cv. Mcintosh are treated with the formulated test compound (0.02% active ingredient) in a spray chamber. One day after, the application apple plants are inoculated by shaking plants infected with apple powdery mildew above the test plants. After an incubation period of 12 days at 22°C and 60%r.h. under a light regime of 14/10hours (light/dark) the disease incidence is assessed.
Compounds 2.005, 3.017, 3.219 and 9.189 each exhibit strong efficacy ( 4 week old apple seedlings cv. Mcintosh are treated with the formulated test compound (0.02% active ingredient) in a spray chamber. One day after application, the apple plants are inoculated by spraying a spore suspension (4xl05conidia/ml) on the test plants. After an incubation period of 4 days at21°C and95%r.h. the plants are placed for ) 4 days at 21°C and 60%r.h. in a greenhouse. After another 4 day incubation period at 21°C and 95%r.h. the disease incidence is assessed.
Compounds 3.017, 3.219 and 9.189 each exhibit strong efficacy (
Example B-4: Action against Erysiphe graminis / barley ("Powdery mildew on barlevl
1 week old barley plants cv. Regina are treated with the formulated test compound (0.02% active ingredient) in a spray chamber. One day after application, the barley plants are inoculated by shaking powdery mildew infected plants above the test plants. After an incubation period of 6 days at 20DC /18°C (day/night) and 60%r.h. in a greenhouse the disease incidence is assessed.
Compounds 2.017,2.029, 2.273, 3.005, 3.017,3.029, 3.067, 3.070, 3.219, 3.273, 3.321,3.407, 8.189, 9.189 and21.017 each exhibit strong efficacy ( 5 week old grape seedlings cv. Gutedel are treated with the formulated test compound (0.02% active ingredient) in a spray chamber. Two days after application, the grape plants are inoculated by spraying a spore suspension (1x10 conidia/ml) on the test plants. After an incubation period of 4 days at 21"C and 95%r.h. in a greenhouse the disease incidence is assessed.
Compounds 2.029, 3.017 and 3.219 each show good activity in this test ( 4 week old tomato plants cv. Roter Gnom are treated with the formulated test compound (0.02% active ingredient) in a spray chamber. Two days after application, the tomato plants are inoculated by spraying a spore suspension (lxl0iconidia/ml) on the test plants. After an incubation period of 4 days a( 20°C and 95%r.h. in a growth chamber the disease incidence is assessed.
Compounds 2.029,3.005, 3.029, 3.067, 3.070,3.219, 3.273, 9.189 and 20.017 each exhibit good efficacy ( 1 week old wheat plants cv. Arina are ireated with 1hs formulated test compound (0.02% active ingredient) in a spray chamber. One day after application, the wheat plants are inoculated by spraying a spore suspension (5x103conidia/ml) on the test plants. After an incubation period of 1 day at 20°C and 95%r.h. the plants are kept for 10 days at 20°C and 60%r.h. in a greenhouse. The disease incidence is assessed 11 days after inoculation.
Compounds 3.273 and 9.189 each show good activity in this test (
Example B-8: Action against Helminthosporium teres / barley (Net blotch on barley-)
] week old barley plants cv. Regina are treated with the formulated test compound (0.02% active ingredient) in a spray chamber. Two days after application, the barley plants are inoculated by spraying a spore suspension (3x 104conidia/ml) on the test plants. After an incubation period of 4 days at 20°C and 95%r.h. in a greenhouse the disease incidence is assessed.
Compounds 2.005,2.017, 2,029, 2.067, 2.070, 2.273, 3.005, 3.017, 3.029, 3.067, 3.070, 3.219, 3.407,9.189 and 21.017 each show good activity in this test ( 4 week old tomato plants cv. Roter Gnom are treated with the formulated test compound (0.02% active ingredient) in a spray chamber. Two days after application, the tomato plants are inoculated by spraying a spore suspension (2xl05conidia/ml) on the test plants. After an incubation period of 3 days at 20°C and 95%r.h. in a growth chamber the disease incidence is assessed.
Compounds 2.005, 2.029, 3.005, 3.017, 3.029 and 9.189 each show good activity in this test ( 5 week old grape seedlings cv. Gutedel are treated with the formulated test compound (0.02% active ingredient) in a spray chamber. One day after application, the grape plants are inoculated by shaking plants infected with grape powdery mildew above the test plants. After an incubation period of 7 days at 26°C and 60%r.h. under a light regime of 14/1 Ohours (light/dark) the disease incidence is assessed.
Compounds 3.017, 3.219 and 9.189 each show good activity in this test (

WE CLAIM:
1. A compound of formula (I):

(A22)
wherein
Q is a single or a double bond;
X is O, N(R,R) or (CR19R30){CR2,R")m(CR"R24)„;
R1 is Ci^haloalkyl;
R1 is CM alkyl or CM aJkoxy(CM)alkyl;
R3 is hydrogen;
R^R^R^R^andR17 arc each, independently, hydrogen orCw alkyl;
R,B is hydrogen. CM alkyl, formyl, C(=0)CM alkyl or C(-0)0-Cu alkyl;
R,p, R30, K2\ RM, R" and RM are each, independently, Ci-6 alkyl, optionally substituted
by aryl, a 3-7 meinbered carbocyclic ring or hydrogen;

or R'*ROT together with the carbon atom to which they are attached form a 3-5 membered carbocyclic ring or Q ^ alkylidcne (optionally substituted by up to three methyl groups); m is 0 or I; and nisO.
2. An intermediate for the preparation of formula (I) according to claim 1, having the formula

where R1 and R1 are as dcGned in claim 1 and Y is halogen, hydroxy or C1.5 alkoxy, provided that when R1 is chtoro and K2 is 4-CHjO-C(H4-CH2-, Y is not C2H3O; when R1 is CHjO and R1 is CHi, Y is not CJHJO; when R1 is bromo and Rz is CH3OCH2, Y is not CH3O; and when R* is CHj and R2 is CJHJ, Y is not OH.
3. An intermediate for the preparation of formula (I) according to claim 1, having the formula

where R,J, R14, R1 \ R,fl, X and Q are as defined in claim 1; provided that when R", R14, R1 s and R, 4. A composition for controlling microorganisms and preventing attack and infestation of plants therewith, wherein the active ingredient is a compound of formula (I) as claimed in claim 1 together with a suitable carrier.

5. A method of controlling or preventing infestation of cultivated plants by phytopathogenic microorganisms by application of a compound of formula (I) as claimed in claim 1 to plants, to parts thereof or the locus thereof.
Dated this 31 day of December 2004

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Patent Number

223690

Indian Patent Application Number

3147/CHENP/2004

PG Journal Number

47/2008

Publication Date

21-Nov-2008

Grant Date

19-Sep-2008

Date of Filing

31-Dec-2004

Name of Patentee

SYNGENTA PARTICIPATIONS AG

Applicant Address

SCHWARZWALDALLEE 215, CH-4058 BASEL,

Inventors:

#	Inventor's Name	Inventor's Address
1	WALTER, HARALD	SCHWARZWALDALLE 215, CH-4058 BASEL,
2	EHRENFREUND, JOSEF	SCHWARZWALDALLE 215, CH-4058 BASEL,
3	TOBLER, HANS	SCHWARZWALDALLE 215, CH-4058 BASEL,

PCT International Classification Number

C07D249/04

PCT International Application Number

PCT/EP03/09111

PCT International Filing date

2003-08-18

PCT Conventions:

#	PCT Application Number	Date of Convention	Priority Country
1	0310464.3	2003-05-07	U.K.
2	0219612.9	2002-08-22	U.K.