| Title of Invention | PROCESS FOR THE PREPARATION OF SUBSTITUTED 3-ARYL-BUTYL-AMINE COMPOUNDS. |
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| Abstract | The present invention relates to a process for the dehydration of substituted 1-amino-3-aryl-butan-3-ol compounds for the preparation of substituted 3- aryl-butyl-amine compounds. |
| Full Text | Patent application by Grünenthal GmbH, D-52078 Aachen (Applicant's reference: GRA 3191) Process for the preparation of substituted 3-aryl-butyl- amine compounds The present invention relates to a process for the dehydration of substituted 1-amino-3--aryl-butan-3-ol compounds for the preparation of substituted 3-aryl-butyl- amine compounds. The treatment of chronic and non-chronic states of pain is of great importance in medicine. This is reflected in the large number of publications. EP 0 693 475 discloses an active compound class of 3-aryl- butyl-amine compounds, in particular dimethyl-(3-aryl- butyl)-amine compounds, with an excellent analgesic activity and very good tolerability. The preparation of these pharmaceutical active compounds starts from tertiary alcohols, these first being converted into the corresponding chloride compound, which is then reduced with zinc borohydride, zinc cyanoborohydride or tin cyanoborohydride. This process has the disadvantage that the preparation of the chloride compound takes place using comparatively aggressive chlorinating agents, such as thionyl chloride, and this furthermore also has to be used in a high excess. In addition, there is a considerable risk of fire and health hazard from the hydrogenation reagents. This process moreover does not proceed with a satisfactory yield in all cases. The object of the present invention was therefore to provide a process for eliminating the tertiary alcohol function from substituted 4-amino-2-aryl-butan-2-ol compounds, with which the correspondingly substituted 3- aryl-butyl-amine compounds are obtained in good yields under environment-friendly conditions. A further aim of the process is to obtain enantiomer purity in the case of the substituted stereochemically pure compounds employed. This object is achieved according to the invention by providing the process described below for the dehydration of substituted l-amino-3-aryl~butan-3-ol compounds of the general formula II given below for the preparation of substituted 3-aryl-butyl-amine compounds of the general formula I given below. The compounds of the general formula I are preferably employed as pharmaceutical active compounds in medicaments and are suitable in particular for combating pain. The present invention therefore provides a process for the preparation of a substituted 3-aryl-butyl-amine compound of the general formula I wherein R1 is chosen from H, C1-3-alkyl, branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted, R2 and R3 in each case independently of one another are chosen from H or C1-4-alkyl, branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted, or R2 and R3 together form a saturated C4-7-cycloalkyl radical, unsubstituted or mono- or polysubstituted, R4 is chosen from H, Ci-3-alkyl, branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted, R7 and R8 in each case independently of one another are chosen from H or C1-3-alkyl, branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted, R9 to R13 in each case independently of one another are chosen from H, F, Cl, Br, I, CH2F, CHF2, CF3, OH, SH, OR14, OCF3, SR14, NR17R18, SOCH3, SOCF3; SO2CH3, SO2CF3, CN, COOR14, N02, CONR17R18; C1-6-alkyl, branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted; phenyl, unsubstituted or mono- or polysubstituted; where R14 is chosen from C1-6-alkyl; pyridyl, thienyl, thiazolyl, phenyl, benzyl or phenethyl, in each case unsubstituted or mono- or polysubstituted; PO (O-C1-4-alkyl) 2, CO(OC1-5-alkyl), CONH-C6H4-(C1-3-alkyl) , CO (C1-5-alkyl) , CO-CHR17- NHR18, CO-C6H4-R15, where R15 is ortho-OCOC1-3-alkyl or meta- or para-CH2N (R16) 2, where R16 is C1-4-alkyl or 4-morpholino, wherein in the radicals R14, R15 and R16 the alkyl groups can be branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted; where R17 and R18 in, each case independently of one another are chosen from H; C1-6-alkyl, branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted; phenyl, benzyl or phenethyl, in each case unsubstituted or mono- or polysubstituted, or R9 and R10 or R10 and R11 together form an OCH2O, OCH2CH2O, OCH=CH, CH=CHO, CH=C (CH3) 0, OC (CH3) =CH, (CH2) 4 or OCH=CHO ring, in each case in the form of one of its pure stereoisomers, in particular enantiomers or diastereomers, its racemates or in the form of a mixture of stereoisomers, in particular the enantiomers or diastereomers, in any desired mixing ratio, or in each case in the form of a physiologically acceptable salt, or in each case in the form of a solvate, characterized in that in a first step a) a 1-amino-3-aryl- butan-3-ol compound of the general formula II wherein R1, R2, R3, R4, R7, R8, R9, R10, R11, R12 and R13 have the abovementioned meaning, in each Case optionally in the form of one of its pure stereoisomers, in particular enantiomers or diastereomers, its racemates or in the form of a mixture of stereoisomers, in particular the enantiomers or diastereomers, in any desired mixing ratio, or in each case in the form of a physiologically acceptable salt, or in each case in the form of a solvate, is employed and elimination is carried out under the action of an acid to give a substituted 3-aryl-but-3-enyl-amine compound of the general formula III wherein R1, R2, R3, R4, R7, R8, R9, R10, R11, R12 and R13 have the abovementioned meaning, in each case optionally in the form of one of its pure stereoisomers, in particular enantiomers or diastereomers, its racemates or in the form of a mixture of stereoisomers, in particular the enantiomers or diastereomers, in any desired mixing ratio, or in each case in the form of a physiologically acceptable salt, or in each case in the form of a solvate, and in a second step b) the substituted 3-aryl-but-3-enyl-amine compound according to the general formula III formed is then hydrogenated under the participation of a metal catalyst and hydrogen to give a substituted 3-aryl-butyl- amine compound of the general formula I. This process allows a synthesis with high yields, good environment-friendliness and high stereoselectivity. In the context of this invention, alkyl and cycloalkyl radicals are understood as meaning saturated and unsaturated (but not aromatic), branched, unbranched and cyclic hydrocarbons, which can be unsubstituted or mono- or polysubstituted. Here, C1-2-alkyl represents C1- or C2- alkyl, C1-3-alkyl represents C1-, C2- or C3-alkyl, C1-4-alkyl represents C1-, C2-, C3- or C4-alkyl, C1-5-alkyl represents C1-, C2-, C3-, C4- or C5-alkyl, C1-6-alkyl represents C1-, C2-, C3-, C4-, C5- or C6-alkyl, C1-7-alkyl represents C1-, C2-, C3-, C4-, C5-, C6- or C7-alkyl, C1-8-alkyl represents C1-, C2-, C3-, C4-, C5-, C6-, C7- or C8-alkyl, C1-10-alkyl represents C1-, C2-, C3-, C4-, C5-, C6-, C7-, C8-, C9- or C1O-alkyl and C1-18-alkyl represents C1-, C2-, C3-, C4-, C5-, C6-, C7-, C8-, C9-, C10-, C11-, C12-, C13-, C14-, C15-, C16-, C17- or C18-alkyl. Furthermore, C3-4-cycloalkyl represents C3- or C4-cycloalkyl, C3-5-cycloalkyl represents C3-, C4- or C5-cycloalkyl, C3-6-cycloalkyl represents C3-, C4-, C5- or C6-cycloalkyl, C3.7-cycloalkyl represents C3-, C4-, C5-, C6- or C7-cycloalkyl, C3-8-cycloalkyl represents C3-, C4-, C5-, C6-, C7- or C8-cycloalkyl, C4-5-cycloalkyl represents C4- or C5-cycloalkyl, C4-6-cycloalkyl represents C4-, C5- or C6-cycloalkyl, C4-7-cycloalkyl represents C4-, C5-, C6-, or C7-cycloalkyl, C5-6-cycloalkyl represents C5- or C6-cycloalkyl and C5-7-cycloalkyl represents C5-, C6- or C7-cycloalkyl. In respect of cycloalkyl, the term also includes saturated cycloalkyls in which one or 2 carbon atoms are replaced by a heteroatom, S, N or 0. The term cycloalkyl however also includes, in particular, mono- or poly-, preferably monounsaturated cycloalkyls without a heteroatom in the ring, as long as the cycloalkyl is not an aromatic system. The alkyl and cycloalkyl radicals are preferably methyl, ethyl, vinyl (ethenyl), propyl, allyl (2-propenyl), 1-propinyl, methylethyl, butyl, 1- methylpropyl, 2-methylpropyl, 1,1-dimethylethyl, pentyl, 1,1-dimethylpropyl, 1,2-dimethylpropyl, 2,2-dimethylpropyl, hexyl, 1-methylpentyl, cyclopropyl, 2-methylcyclopropyl, cyclopropylmethyl, cyclobutyl, cyclopentyl, cyclopentylmethyl, cyclohexyl, cycloheptyl, cyclooctyl, and also adamantyl, CHF2, CF3 or CH2OH as well as pyrazolinone, oxopyrazolinone, [1,4]-dioxane or dioxolane. In connection with alkyl and cycloalkyl - as long as this is not expressly defined otherwise - the term substituted in the context of this invention is understood here as meaning substitution of at least one (optionally also several) hydrogen radical(s) by F, Cl, Br, I, NH2, SH or OH, "polysubstituted" or "substituted" in the case of multiple substitution being understood as meaning that the substitution occurs several times both on different and on the same atoms by identical or different substituents, for example three times on the same C atom, as in the case of CF3, or at different places, as in the case of -CH(OH)- CH=CH-CHC12. Particularly preferred substituents here are F, Cl and OH. In respect of cycloalkyl, the hydrogen radical can also be replaced by OC1-3-alkyl or C1-3-alkyl (in each case mono- or polysubstituted or unsubstituted), in particular methyl, ethyl, n-propyl, i-propyl, CF3, methoxy or ethoxy. The term (CH2)3-6 is to be understood as meaning -CH2-CH2- CH2-, -CH2-CH2-CH2-CH2-, -CH2-CH2-CH2-CH2-CH2- and -CH2-CH2-CH2- CH2-CH2-CH2-, (CH2)1-4 is to be understood as meaning -CH2-, -CH2-CH2-, -CH2-CH2-CH2- and -CH2-CH2-CH2-CH2-, (CH2)4-5 is to be understood as meaning -CH2-CH2-CH2-CH2- and -CH2-CH2-CH2- CH2-CH2-, etc. An aryl radical is understood as meaning ring systems with at least one aromatic ring but without heteroatoms in even only one of the rings. Examples are phenyl, naphthyl, fluoranthenyl, fluorenyl, tetralinyl or indanyl, in particular 9H-fluorenyl or anthracenyl radicals, which can be unsubstituted or mono- or polysubstituted. A heteroaryl radical is understood as meaning heterocyclic ring systems with at least one unsaturated ring, which contain one or more heteroatoms from the group consisting of nitrogen, oxygen and/or sulfur and can also be mono- or polysubstituted. Examples which may be mentioned from the group of heteroaryls are furan, benzofuran, thiophene, benzothiophene, pyrrole, pyridine, pyrimidine, pyrazine, quinoline, isoquinoline, phthalazine, benzo-1,2,5- thiadiazole, benzothiazole, indole, benzotriazole, benzodioxolane, benzodioxane, carbazole, indole and quinazoline. In connection with aryl and heteroaryl, substituted is understood here as meaning substitution of the aryl or heteroaryl by R23, OR23, a halogen, preferably F and/or Cl, a CF3, a CN, an N02/ an NR24R25, a C1-6-alkyl (saturated), a C1-6-alkoxy, a C3-8-cycloalkoxy, a C3-8-cycloalkyl or a C2-6-alkylene. The radical R23 here represents H, a C1-10-alkyl, preferably a C1-6-alkyl, an aryl or heteroaryl or an aryl or heteroaryl radical bonded via a C1-3-alkyl group, where these aryl and heteroaryl radicals may not themselves be substituted by aryl or heteroaryl radicals, the radicals R24 and R25, which are identical or different, represent H, a C1-10-alkyl, preferably a C1-6-alkyl, an aryl, a heteroaryl or an aryl or heteroaryl radical bonded via a C1-3-alkylene group, where these aryl and heteroaryl radicals may not themselves be substituted by aryl or heteroaryl radicals, or the radicals R24 and R25 together denote CH2CH2OCH2CH2, CH2CH2NR26CH2CH2 or (CH2)3-6, and the radical R26 represents H, a C1-10-alkyl, preferably a C1-6-alkyl, an aryl or heteroaryl radical or an aryl or heteroaryl radical bonded via a C1-3-alkylene group, where these aryl and heteroaryl radicals may not themselves be substituted by aryl or heteroaryl radicals. The term salt in the context of this invention is to be understood as meaning any form of the active compound according to the invention in which this assumes an ionic form or is charged and is coupled with a counter-ion (a cation or anion) or is in solution. This is also to be understood as meaning complexes of the active compound with other molecules and ions, in particular complexes complexed via ionic interactions. The term of the physiologically acceptable salt (in particular with cations or bases) in the context of this invention is understood as meaning salts of at least one of the compounds according to the invention - usually of a (deprotonated) acid - as the anion with at least one preferably inorganic cation, which are physiologically - especially when used in humans and/or mammals - acceptable. The salts of the alkali metals and alkaline earth metals and also with NH4+ are particularly preferred, but in particular (mono-) or (di-)sodium, (mono-) or (di-)potassium, magnesium or calcium salts. The term of the physiologically acceptable salt (in particular with anions or acids) in the context of this invention is furthermore understood as meaning salts of at least one of the compounds according to the invention - usually protonated, for example on the nitrogen - as the cation with at least one anion, which are physiologically - especially when used in humans and/or mammals - acceptable. In particular, in the context of this invention this is understood as meaning the salt formed with a physiologically acceptable acid, that is to say salts of the particular active compound with inorganic or organic acids which are physiologically - especially when used in humans and/or mammals - acceptable. Examples of physiologically acceptable salts of particular acids are salts of: hydrochloric acid, hydrobromic acid, sulfuric acid, methanesulfonic acid, formic acid, acetic acid, oxalic acid, succinic acid, malic acid, tartaric acid, mandelic acid, fumaric acid, lactic acid, citric acid, glutamic acid, 1,1-dioxo-l,2-dihydroip6-benzo[d]isothiazol- 3-one (saccharic acid), monomethylsebacic acid, 5-oxo- proline, hexane-1-sulfonic acid, nicotinic acid, 2-, 3- or 4-aminobenzoic acid, 2 , 4 , 6-trimethyl-benzoic acid, a- liponic acid, acetylglycine, acetylsalicylic acid, hippuric acid and/or aspartic acid. The hydrochloride salt is particularly preferred. Suitable salts in the context of this invention and in each use described and each of the medicaments described are salts of the particular active compound with inorganic or organic acids and/or a sugar substitute, such as saccharin, cyclamate or acesulfam. However, the hydrochloride is particularly preferred. Compounds according to formula I and according to formula II and their preparation are known from DE 44 26 245 Al and US 6,248,737. Compounds according to formula III are known from EP 799 819 and US 5,811,582. In some cases it is preferable for the product to be isolated between step a and step b. For this, after the elimination according to step a) the mixture is first neutralized with a base, preferably an ammonium compound or a hydroxide compound, in particular a solution of an alkali metal or alkaline earth metal hydroxide, preferably NaOH or KOH solution, and/or a basic pH, preferably > pH 9, in particular > pH 10, preferably between pH 10 and pH 12.5, is first established. An organic solvent, preferably a weakly water-soluble, polar organic solvent, in particular an organic acid ester, preferably ethyl acetate or methyl acetate, is then added and the mixture is stirred. This step is also possible without a solvent or using diisopropyl ester. The aqueous phase which remains is then discarded and the desired product is isolated from the organic phase, preferably by distillation, in particular in vacuo. It is preferable for the process according to the invention if, for compounds according to formula I, formula II and formula III, R4 is chosen from H or CH3, preferably R4 denotes H. It is preferable for the process according to the invention if, for compounds according to formula I, formula II and formula III, R1 is chosen from C1-3-alkyl, saturated or unsaturated, substituted or unsubstituted, branched or unbranched. It is preferable for the process according to the invention if, for compounds according to formula I, formula II and formula III, R4 is chosen from H or CH3, preferably R4 denotes H, and/or R1 is chosen from C1-3-alkyl, saturated or unsaturated, substituted or unsubstituted, branched or unbranched. It is preferable for the process according to the invention if, for compounds according to formula I, formula II and formula III, R7 and R8 in each case independently of one another are chosen from H or CH3, preferably R7 and R8 denote H or R7 and R8 denote CH3 or R7 denotes H and R8 denotes CH3, in particular R7 and R8 denote CH3. It is preferable for the process according to the invention if, for compounds according to formula I, formula II and formula III, R1 is chosen from C1-3-alkyl, saturated and unsubstituted, branched or unbranched, preferably from CH3, C2H5, i-propyl or n-propyl, in particular from CH3 or C2H5. It is preferable for the process according to the invention if, for compounds according to formula I, formula II and formula III, R2 and R3 independently of one another are chosen from H, C1-4-alkyl, saturated and unsubstituted, branched or unbranched; preferably from H, CH3, C2H5, i-propyl or t-butyl, in particular from H or CH3 or C2H5. It is preferable for the process according to the invention if, for compounds according to formula I, formula II and formula III, R3 = H and R2 ? H, preferably R3 = H and R2 = CH3 or C2H5, in particular R3 = H and R2 = CH3. It is preferable for the process according to the invention if, for compounds according to formula I, formula II and formula III, R2 and R3 together form a C5-6-cycloalkyl radical, saturated or unsaturated, unsubstituted or mono- or polysubstituted, preferably saturated and unsubstituted, in particular cyclohexyl. It is preferable for the process according to the invention if, for compounds according to formula I, formula II and formula III, R9 to R13, where 3 or 4 of the radicals R9 to R13 must correspond to H, independently of one another are chosen from H, Cl, F, OH, CF2H, CF3 or C1-4-alkyl, saturated and unsubstituted, branched or unbranched; OR14 or SR14, where R14 is chosen from C1-3-alkyl, saturated and unsubstituted, branched or unbranched; preferably from H, Cl, F, OH, CF2H, CF3, OCH3 or SCH3 or R12 and R11 form a 3,4-OCH=CH ring in particular if R9, R11 and R13 correspond to H, one of R10 or R12 also corresponds to H, while the other is chosen from: Cl, F, OH, CF2H, CF3/ OR14 or SR14, preferably from OH, CF2H, OCH3 or SCH3 or if R9 and R13 correspond to H and R11 corresponds to OH, OCH3, Cl or F, preferably Cl, one of R10 or R12 also corresponds to H, while the other corresponds to OH, OCH3, Cl or F, preferably Cl, or if R9, R10, R12 and R13 correspond to H, R11 is chosen from CF3; CF2H, Cl or F, preferably from F, or if R10; R11 and R12 correspond to H, one of R9 or R13 also corresponds to H, while the other is chosen from OH, OC2H5 or OC3H7. It is preferable for the process according to the invention if, for compounds according to formula I, formula II and formula III, R1 is chosen from C1-3-alkyl, saturated and unsubstituted, branched or unbranched; preferably CH3, C2H5, or C3H7, in particular CH3 or C2H5, and/or R2 and R3 independently of one another are chosen from H, C1-4-alkyl, saturated and unsubstituted, branched or unbranched; preferably from H, CH3, C2H5, i-propyl or t-butyl, in particular from H or CH3 or C2H5, preferably: R3 = H and R2 ? H, preferably R3 = H and R2 = CH3 or C2H5, in particular R3 = H and R2 = CH3, or R2 and R3 together form a C5-6-cycloalkyl radical, saturated or unsaturated, unsubstituted or mono- or polysubstituted, preferably saturated and unsubstituted, in particular cyclohexyl, and/or R4 is chosen from H, and/or R7 and R8 in each case independently of one another are chosen from H or CH3/ preferably R7 and R8 denote H or R7 and R8 denote CH3 or R7 denotes H and R8 denotes CH3, in particular R7 and R8 denote CH3; and/or R9 to R13, where 3 or 4 of the radicals R9 to R13 must correspond to H, independently of one another are chosen from H, Cl, F, OH, CF2H, CF3 or C1-4-alkyl, saturated and unsubstituted, branched or unbranched; OR14 or SR14, where R14 is chosen from C1-3-alkyl, saturated and unsubstituted, branched or unbranched; preferably from H, Cl, F, OH, CF2H, CF3, OCH3 or SCH3 or R12 and R11 form a 3,4-OCH=CH ring in particular if R9, R11 and R13 correspond to H, one of R10 or R12 also corresponds to H, while the other is chosen from: Cl, F, OH, CF2H, CF3/ OR14 or SR14, preferably from OH, CF2H, OCH3 or SCH3 or if R9 and R13 correspond to H and R11 corresponds to OH, OCH3, Cl or F, preferably Cl, one of R10 or R12 also corresponds to H, while the other corresponds to OH, OCH3, Cl or F, preferably Cl, or if R9, R10, R12 and R13 correspond to H, R11 is chosen from CF3, CF2H, Cl or F, preferably from F, or if R10, R11 and R12 correspond to H, one of R9 or R13 also corresponds to H, while the other is chosen from OH, OC2H5 or OC3H7. It is preferable for the process according to the invention if, for compounds according to formula I where R3 = H and R2 ? H, these are in the configurations Ia or Ib It is preferable for the process according to the invention if, for compounds according to formula II where R3 = H and R2 ? H, these are in the configurations IIa or IIb or in the configurations IIc and IId It is preferable for the process according to the invention if, for compounds according to formula III where R3 = H, R2 ? H, R4 = H and R1 ? H, these are in the configurations IIIa or IIIb or for compounds according to formula III where R3 = H, R2 ? H, R4 = H and R1 ? H, these are in the configurations IIIc or IIId It is preferable for the process according to the invention if, for the compound/compounds according to formula I, at least one of these, preferably as the free base or as the hydrochloride, is chosen from the following group: ¦ 3-(3-dimethylamino-l-ethyl-2-methyl-propyl)- phenol, ¦ (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl- propyl)-phenol ¦ (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl- propyl)-phenol, ¦ (1S,2S)-3-(3-dimethylamino-1-ethyl-2-methyl- propyl)-phenol ¦ (+)-(1S,2S)-3-(3-dimethylamino-1-ethyl-2-methyl- propyl)-phenol ¦ (+)-(1RS,2RS)-3-(3-dimethylamino-1-ethyl-2- methyl-propyl)-phenol ¦ rac-(1RS,2RS)-3-(3-dimethylamino-l-ethyl-2- methyl-propyl)-phenol, ¦ [3-(3-methoxy-phenyl)-2-methyl-pentyl]- dimethylamine, ¦ (2R,3R)-[3-(3-methoxy-phenyl)-2-methyl-pentyl]- dimethylamine, ¦ (-)-(2R,3R)-[3-(3-methoxy-phenyl)-2-methyl- pentyl]-dimethylamine, ¦ (2S,3S)-[3-(3-methoxy-phenyl)-2-methyl-pentyl]- dimethylamine, ¦ (+)-(2S,3S)-[3-(3-methoxy-phenyl)-2-methyl- pentyl]-dimethylamine, ¦ (±)-(2RS,3RS)-[3-(3-methoxy-phenyl)-2-methyl- pentyl]-dimethylamine, ¦ rac(2RS,3RS)-[3-(3-methoxy-phenyl)-2-methyl- pentyl]-dimethylamine, ¦ 3{ [3- (p-isopropyl-phenyl-carbamoyl) -oxy-phenyl] - 2-methyl-pentyl}-dimethylamine, ¦ (2R,3R)-{3[3-(p-isopropyl-phenyl-carbamoyl)-oxy- phenyl] -2-methyl-pentyl}-dimethylamine, ¦ (2S,3S)-{3[3-(p-isopropyl-phenyl-carbamoyl)-oxy- phenyl] -2-methyl-pentyl}-dimethylamine, ¦ (2SR,3SR)-{3[3-(p-isopropyl-phenyl-carbamoyl)- oxy-phenyl]-2-methyl-pentyl}-dimethylamine preferably ¦ 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)- phenol, ¦ (1R,2R)-3-(3-dimethylamino-l-ethyl-2-methyl- propyl)-phenol, ¦ (-)-(1R,2R)-3-(3-dimethylamino-l-ethyl-2-methyl- propyl)-phenol, ¦ (1S,2S)-3-(3-dimethylamino-l-ethyl-2-methyl- propyl)-phenol, ¦ (+)-(IS,2S)-3-(3-dimethylamino-l-ethyl-2-methyl- propyl)-phenol, ¦ (±)-(1RS,2RS)-3-(3-dimethylamino-l-ethyl-2- methyl-propyl)-phenol, ¦ rac-(1RS,2RS)-3-(3-dimethylamino-l-ethyl-2- methyl-propyl)-phenol, ¦ [3-(3-methoxy-phenyl)-2-methyl-pentyl]- dimethylamine, ¦ (2R,3R)-[3-(3-methoxy-phenyl)-2-methyl-pentyl]- dimethylamine, ¦ (-)-(2R,3R)-[3-(3-methoxy-phenyl)-2-methyl- pentyl]-dimethylamine, ¦ (2S,3S)-[3-(3-methoxy-phenyl)-2-methyl-pentyl]- dimethylamine, ¦ (+)-(2S,3S)-[3-(3-methoxy-phenyl)-2-methyl- pentyl]-dimethylamine, in particular ¦ [3-(3-methoxy-phenyl)-2-methyl-pentyl]- dimethylamine, ¦ (2R,3R)-[3-(3-methoxy-phenyl)-2-methyl-pentyl]- dimethylamine, ¦ (-)-(2R,3R)-[3-(3-methoxy-phenyl)-2-methyl- pentyl]-dimethylamine, ¦ (2S,3S)- [3-(3-methoxy-phenyl)-2-methyl-pentyl]- dimethylamine, ¦ ( + )-(2S,3S)-[3- (3-methoxy-phenyl) - 2-methyl- pentyl]-dimethylamine. It is preferable for the process according to the invention if, for the compound/compounds according to formula II employed, at least one of these, preferably as the free base or as the hydrochloride, is chosen from the following group: ¦ 3-(3-dimethylamino-l-ethyl-l-hydroxy-2-methyl- propyl)-phenol, ¦ (1S,2S)-3-(3-dimethylamino-l-ethyl-l-hydroxy-2- methyl-propyl)-phenol, ¦ (1R,2S)-3-(3-dimethylamino-l-ethyl-l-hydroxy-2- methyl-propyl)-phenol, ¦ (1RS,2SS)-3-(3-dimethylamino-l-ethyl-l-hydroxy-2- methyl-propyl)-phenol, ¦ (1S,2R)-3-(3-dimethylamino-l-ethyl-l-hydroxy-2- methyl-propyl)-phenol, ¦ (1R,2R)-3-(3-dimethylamino-l-ethyl-l-hydroxy-2- methyl-propyl)-phenol, ¦ (1RS,2RR)-3-(3-dimethylamino-l-ethyl-l-hydroxy-2- methyl-propyl)-phenol, ¦ [3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol]- dimethylamine, ¦ (2S,3S)-[3-(3-methoxy-phenyl)-2-methyl-pentan-3- ol]-dimethylamine, ¦ (2S,3R)-[3-(3-methoxy-phenyl)-2-methyl-pentan-3- ol]-dimethylamine, ¦ (2SS,3RS)-[3-(3-methoxy-phenyl)-2-methyl-pentan- 3-ol]-dimethylamine, ¦ (2R,3S)-[3-(3-methoxy-phenyl)-2-methyl-pentan-3- ol]-dimethylamine, ¦ (2R,3R)-[3-(3-methoxy-phenyl)-2-methyl-pentan-3- ol]-dimethylamine ¦ (2RR,3RS)-[3-(3-methoxy-phenyl)-2-methyl-pentan- 3-ol]-dimethylamine, ¦ {3[3-(p-isopropyl-phenyl-carbamoyl)-oxy-phenyl]- 2-methyl-pentan-3-ol}-dimethylamine, ¦ (2S,3R)-{3[3-(p-isopropyl-phenyl-carbamoyl)-oxy- phenyl] -2-methyl-pentan-3-ol}-dimethylamine, ¦ (2S,3S)-{3[3-(p-isopropyl-phenyl-carbamoyl)-oxy- phenyl] -2-methyl-pentan-3-ol}-dimethylamine ¦ (2SS,3RS)-{3[3-(p-isopropyl-phenyl-carbamoyl)- oxy-phenyl]-2-methyl-pentan-3-ol}-dimethylamine, ¦ (2R,3S)-{3[3-(p-isopropyl-phenyl-carbamoyl)-oxy- phenyl] -2-methyl-pentan-3-ol}-dimethylamine, ¦ (2R,3R)-{3[3-(p-isopropyl-phenyl-carbamoyl)-oxy- phenyl] -2-methyl-pentan-3-ol}-dimethylamine, ¦ (2RR,3RS)-{3[3-(p-isopropyl-phenyl-carbamoyl)- oxy-phenyl]-2-methyl-pentan-3-ol}-dimethylamine, preferably ¦ 3-(3-dimethylamino-l-ethyl-l-hydroxy-2-methyl- propyl)-phenol, ¦ (1S,2S)-3-(3-dimethylamino-l-ethyl-l-hydroxy-2- methyl-propyl)-phenol, ¦ (1R,2S)-3-(3-dimethylamino-l-ethyl-l-hydroxy-2- methyl-propyl)-phenol, ¦ (1RS,2SS)-3-(3-dimethylamino-l-ethyl-l-hydroxy-2- methyl-propyl)-phenol, ¦ (1S,2R)-3-(3-dimethylamino-l-ethyl-l-hydroxy-2- methyl-propyl)-phenol, ¦ (1R,2R)-3-(3-dimethylamino-l-ethyl-l-hydroxy-2- methyl-propyl)-phenol, ¦ (IRS,2RR)-3-(3-dimethylamino-l-ethyl-l-hydroxy-2- methyl-propyl)-phenol, ¦ [3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol]- dimethylamine, ¦ (2S,3S)-[3-(3-methoxy-phenyl)-2-methyl-pentan-3- ol]-dimethylamine, ¦ (2S,3R)-[3-(3-methoxy-phenyl)-2-methyl-pentan-3- ol]-dimethylamine, ¦ (2SS,3RS)-[3-(3-methoxy-phenyl)-2-methyl-pentan- 3-ol]-dimethylamine, ¦ (2R,3S)-[3-(3-methoxy-phenyl)-2-methyl-pentan-3- ol]-dimethylamine, ¦ (2R,3R)-[3-(3-methoxy-phenyl)-2-methyl-pentan-3- ol]-dimethylamine, ¦ (2RR,3RS)-[3-(3-methoxy-phenyl)-2-methyl-pentan- 3-ol]-dimethylamine, in particular ¦ [3- (3-methoxy-phenyl)-2-methyl-pentan-3-ol]- dimethylamine, ¦ (2S,3S)- [3-(3-methoxy-phenyl)-2-methyl-pentan-3- ol]-dimethylamine, ¦ (2S,3R)-[3-(3-methoxy-phenyl)-2-methyl-pentan-3- ol]-dimethylamine, ¦ (2SS,3RS)-[3-(3-methoxy-phenyl)-2-methyl-pentan- 3-ol]-dimethylamine, ¦ (2R,3S)-[3-(3-methoxy-phenyl)-2-methyl-pentan-3- ol]-dimethylamine, ¦ (2R,3R)-[3-(3-methoxy-phenyl)-2-methyl-pentan-3- ol]-dimethylamine, ¦ (2RR,3RS)-[3-(3-methoxy-phenyl)-2-methyl-pentan- 3-ol]-dimethylamine, preferably ¦ (2S,3S)-[3-(3-methoxy-phenyl)-2-methyl-pentan-3- ol]-dimethylamine, ¦ (2S,3R)-[3-(3-methoxy-phenyl)-2-methyl-pentan-3- ol]-dimethylamine, or ¦ (2R,3R)-[3-(3-methoxy-phenyl)-2-methyl-pentan-3- ol]-dimethylamine or ¦ (2R,3S)-[3-(3-methoxy-phenyl)-2-methyl-pentan-3- ol]-dimethylamine. It is preferable for the process according to the invention if, for the compound/compounds according to formula III, at least one of these, preferably as the free base or as the hydrochloride, is chosen from the following group: ¦ 3-(3-dimethylamino-l-ethenyl-2-methyl-propyl)- phenol, ¦ (Z)-(2R)-3-(3-dimethylamino--l-ethenyl-2-methyl- propyl)-phenol, ¦ (E)-(2R)-3-(3-dimethylamino-l-ethenyl-2-methyl- propyl)-phenol, ¦ (Z,E)-(2R)-3-(3-dimethylamino-l-ethenyl-2-methyl- propyl)-phenol, ¦ (Z)-(2S)-3-(3-dimethylamino-l-ethenyl-2-methyl- propyl)-phenol, ¦ (E)-(2S)-(3-dimethylamino-l-ethenyl-2-methyl- propyl)-phenol, ¦ (Z,E)-(2S)-3-(3-dimethylamino-l-ethenyl-2-methyl- propyl)-phenol, ¦ 3-(3-dimethylamino-l-ethenyl-2-methyl-propyl)- phenol, ¦ (Z)-(2R)-3-(3-dimethylamino-l-ethenyl-l-2-methyl- propyl)-phenol, ¦ (E)-(2R)-3-(3-dimethylamino-l-ethenyl-l-2-methyl- propyl)-phenol, ¦ (Z,E)-(2R)-3-(3-dimethylamino-l-ethenyl-l-2- methyl-propyl)-phenol, ¦ (Z)-(2S)-3-(3-dimethylamino-l-ethenyl-l-2-methyl- propyl)-phenol, ¦ (E)-(2S)-(3-dimethylamino-l-ethenyl-l-2-methyl- propyl)-phenol, ¦ (Z,E)-(2S)-3- (3-dimethylamino-l-ethenyl-2-methyl- propyl)-phenol, ¦ [3-(3-methoxy-phenyl)-2-methyl-pent-3-enyl]- dimethylamine, ¦ (Z)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (E)- (2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (Z,E) - (2R) - [3- (3-methoxy-phenyl) -2-methyl-pent-3- enyl]-dimethylamine, ¦ (Z)- (2S)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (E)-(2S)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (Z,E)-(2S)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ {3 [3- (p-isopropyl-phenyl-carbamoyl)-oxy-phenyl]- 2-methyl-pent-3-enyl}-dimethylamine, ¦ (Z)-(2R)-{3[3-(p-isopropyl-phenyl-carbamoyl)-oxy- phenyl] -2-methyl-pent-3-enyl}-dimethylamine, ¦ (E)-(2R)-{3[3-(p-isopropyl-phenyl-carbamoyl)-oxy- phenyl] -2-methyl-pent-3-enyl}-dimethylamine, ¦ (Z,E)-(2R)-{3[3-(p-isopropyl-phenyl-carbamoyl)- oxy-phenyl]-2-methyl-pent-3-enyl}-dimethylamine, ¦ (Z)-(2S)-{3[3-(p-isopropyl-phenyl-carbamoyl)-oxy- phenyl] -2-methyl-pent-3-enyl}-dimethylamine, ¦ (E)-(2S)-{3[3-(p-isopropyl-phenyl-carbamoyl)-oxy- phenyl] -2-methyl-pent-3-enyl}-dimethylamine, ¦ (Z,E)-(2S)-{3[3-(p-isopropyl-phenyl-carbamoyl)- oxy-phenyl]-2-methyl-pent-3-enyl}-dimethylamine, preferably ¦ 3-(3-dimethylamino-l-ethenyl-l-2-methyl-propyl)- phenol, ¦ (Z)-(2R)-3-(3-dimethylamino-l-ethenyl-2-methyl- propyl)-phenol, ¦ (E)-(2R)-3-(3-dimethylamino-l-ethenyl-2-methyl- propyl)-phenol, ¦ (Z,E)-(2R)-3-(3-dimethylamino-l-ethenyl-2-methyl- propyl)-phenol, ¦ (Z) - (2S) -3- (3-dimethylatnino-l-ethenyl-2-methyl- propyl)-phenol, ¦ (E)-(2S)-(3-dimethylamino-l-ethenyl-2-methyl- propyl)-phenol, ¦ (Z,E)-(2S)-3-(3-dimethylamino-l-ethenyl-2-methyl- propyl)-phenol, ¦ [3-(3-methoxy-phenyl)-2-methyl-pent-3-enyl]- dimethylamine, ¦ (Z)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (E)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (Z,E)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (Z)-(2S)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (E)-(2S)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (Z,E)-(2S)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, in particular ¦ [3-(3-methoxy-phenyl)-2-methyl-pent-3-enyl]- dimethylamine, ¦ (Z)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (E)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (Z,E)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (Z)-(2S)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl] -dimethylatnine, ¦ (E)- (2S)- [3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (Z,E)-(2S)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, preferably ¦ (Z)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (E)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine or ¦ (Z,E)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, or ¦ (Z)-(2S)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (E)-(2S)- [3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl}-dimethylamine or ¦ (Z,E)-(2S)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine. It is particularly preferable for the process according to the invention if a chiral centre is present in the compound according to formula II employed, at position 2 according to formula II. It is particularly preferable for the process according to the invention if a chiral centre is present in the compound according to formula I, at position 2 according to formula I. It is preferable for the process according to the invention if a chiral centre is present in the compound according to formula III, at position 2 according to formula III. It is preferable for the process according to the invention if the compound according to formula II employed is enantiomerically pure. It is preferable for the process according to the invention if the compound according to formula II employed is diastereomerically pure. It is preferable for the process according to the invention if the compound according to formula II employed is enantiomerically and diastereomerically pure. It is particularly preferable for the process according to the invention if the compound according to formula II employed is chosen from: • (2S),3S)-[3-(3-methoxy-phenyl)-2-methyl- pentan-3-ol]-dimethylamine, • (2S,3R)-[3-(3-methoxy-phenyl)-2-methyl- pentan-3-ol]-dimethylamine or is a mixture of (2S, 3S)-[3-(3-methoxy-phenyl)-2- methyl-pentan-3-ol]-dimethylamine and (2S, 3R) - [3-(3- methoxy-phenyl)-2-methyl-pentan-3-ol]-dimethylamine, or (2SS,3RS)-[3-(3-methoxy-phenyl)-2-methyl-pentan-3- ol]-dimethylamine. It is particularly preferable for the process according to the invention if the compound according to formula II employed is chosen from: • (2R,3R)-[3-(3-methoxy-phenyl)-2-methyl- pentan-3-ol]-dimethylamine, • (2R,3S)-[3-(3-methoxy-phenyl)-2-methyl- pentan-3-ol]-dimethylamine or is a mixture of (2R,3R)-[3-(3-methoxy-phenyl)-2- methyl-pentan-3-ol]-dimethylamine and (2R, 3S) - [3-(3- methoxy-phenyl)-2-methyl-pentan-3-ol]-dimethylamine, or (2RR,3RS)-[3-(3-methoxy-phenyl)-2-methyl-pentan-3- ol]-dimethylamine. It is preferable for the process according to the invention if the compound according to formula II employed is chosen from: • (2S,3S)-l-dimethylamino-3-(3-methoxy- phenyl) -2-methyl-pentan-3-ol, • (2S,3R)-l-dimethylamino-3-(3-methoxy- phenyl) -2-methyl-pentan-3-ol or is a mixture of (2S,3S)-l-dimethylamino-3-(3-methoxy- phenyl) -2-methyl-pentan-3-ol and (2S,3R)-1- dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3- ol, or (2SS,3RS)- [3-(3-methoxy-phenyl)-2-methyl- pentan-3-ol]-dimethylamine. It is preferable for the process according to the invention if the compound according to formula II employed is chosen from: • (2R,3R)-1-dimethylamino-3-(3-methoxy- phenyl)-2-methyl-pentan-3-ol, • (2R,3S)-l-dimethylamino-3-(3-methoxy- phenyl)-2-methyl-pentan-3-ol or is a mixture of (2R,3R)-l-dimethylamino-3-(3-methoxy- phenyl)-2-methyl-pentan-3-ol and (2R,3S)-1- dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3- ol, or (2RR,3RS)-[3-(3-methoxy-phenyl)-2-methyl- pentan-3-ol]-dimethylamine. It is preferable for the process according to the invention if organic acids or halogen halide acids are used in step a) . It is preferable for the process according to the invention if formic acid, hydrochloric acid or hydrobromic acid are used in step a). It is preferable for the process according to the invention if formic acid is used in step a). It is preferable for the process according to the invention if hydrochloric acid is used in step a). It is preferable for the process according to the invention if hydrobromic acid is used in step a). It is preferable for the process according to the invention if the acid in step a) is employed in a high concentration. It is preferable for the process according to the invention if the hydrochloric acid in step a) is > 2 0%, preferably > 30%, in particular > 35%. It is preferable for the process according to the invention if, after step a), the compounds according to formula III which have undergone elimination are crystallized with hydrochloric acid gas. It is preferable for the process according to the invention if the reaction time of step a) is between 2 and 10 h, preferably between 3 and 8 h, in particular between 4 and 6 h. It is preferable for the process according to the invention if the reaction temperature in step a) is between 35 and 100°C, preferably 45 and 80°C, in particular between 50 and 60°C. It is preferable for the process according to the invention if the solvent in step a) is chosen from: H2O or alcohol or aqueous alcohol solutions. It is preferable for the process according to the invention if the solvent in step a) is aqueous acid. It is preferable for the process according to the invention if, in step a), the compound according to formula II employed is dissolved in aqueous acid. It is preferable for the process according to the invention if, in step a), the compound according to formula II employed is dissolved in aqueous hydrochloric acid. It is preferable for the process according to the invention if, in step b), the solvent is chosen from: H20 or alcohol or aqueous alcoholic or aqueous acidic solutions, preferably from aqueous acidic solutions. It is preferable for the process according to the invention if, in step b), the solvent is chosen from: H20 or ethanol or aqueous ethanolic solution or aqueous hydrochloric acid, preferably from aqueous hydrochloric acid. It is preferable for the process according to the invention if, in step b), the catalyst used comprises a noble metal, preferably platinum, gold or palladium., in particular palladium. It is preferable for the process according to the invention if, in step b), the catalyst used is palladium-on-active charcoal or palladium(II) chloride. It is preferable for the process according to the invention if, in step b), the catalyst used is palladium-on-active charcoal (1 - 10 wt.%, preferably 5 wt.%). It is preferable for the process according to the invention if the temperature in step b) is kept between 20 and 40°C, preferably between 20 and 35, in particular 25°C. It is preferable for the process according to the invention if, in step b), an inert gas atmosphere, in particular a nitrogen inert gas, is applied before the hydrogenation. It is preferable for the process according to the invention if, in step b), the hydrogenation step takes place under a hydrogen pre-pressure of 3-10 bar, preferably 4-7 bar, in particular 5 bar and/or the hydrogenation step takes place under a hydrogen internal pressure of 0.5-3 bar, preferably 0.75-2 bar, in particular 1 bar. It is preferable for the process according to the invention if, in step b), the starting substances are highly dilute/diluted in the solvent at the start. It is preferable for the process according to the invention if the solvent for both steps a) and b) is an aqueous acidic solution, preferably aqueous hydrochloric acid. It is preferable for the process according to the invention if no product is isolated between step a) and step b). It is particularly preferable here if the starting substances are highly dilute/diluted in the solvent at the start or the compound according to formula II employed is dissolved in aqueous acid, in particular the compound according to formula II employed is dissolved in aqueous hydrochloric acid. The invention also provides a process, called part process in the following, for the preparation of a substituted 3- aryl-butyl-amine compound of the general formula I wherein R1 is chosen from H, C1-3-alkyl, branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted, R2 and R3 in each case independently of one another are chosen from H or C1-4-alkyl, branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted, or R2 and R3 together form a saturated C4-7-cycloalkyl radical, unsubstituted or mono- or polysubstituted, R4 is chosen from H, C1-3-alkyl, branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted, R7 and R8 in each case independently of one another are chosen from H or C1-3-alkyl, branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted, R9 to R13 in each case independently of one another are chosen from H, F, Cl, Br, I, CH2F, CHF2, CF3, OH, SH, OR14, OCF3, SR14, NR17R18, SOCH3, SOCF3; SO2CH3, SO2CF3, CN, COOR14, N02, CONR17R18; C1-6-alkyl, branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted; phenyl, unsubstituted or mono- or polysubstituted; where R14 is chosen from C1-6-alkyl; pyridyl, thienyl, thiazolyl, phenyl, benzyl or phenethyl, in each case unsubstituted or mono- or polysubstituted; PO (O-C1-4-alkyl) 2, CO (OC1-5-alkyl) , CONH-CSH4-(d-3-alkyl) , CO (C1-5-alkyl) , CO-CHR17- NHR18, CO-C6H4-R15, where R15 is ortho-OCOC1-3-alkyl or meta- or para-CH2N(R16) 2, where R16 is C1-4-alkyl or 4-morpholino, wherein in the radicals R14, R15 and R16 the alkyl groups can be branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted; where R17 and R18 in each case independently of one another are chosen from H; C1-6-alkyl, branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted; phenyl, benzyl or phenethyl, in each case unsubstituted or mono- or polysubstituted, or R9 and R10 or R10 and R11 together form an OCH2O, OCH2CH2O, OCH=CH, CH=CHO, CH=C (CH3) 0, OC (CH3) =CH, (CH2) 4 or OCH=CHO ring, in each case in the form of one of its pure stereoisomers, in particular enantiomers or diastereomers, its racemates or in the form of a mixture of stereoisomers, in particular the enantiomers or diastereomers, in any desired mixing ratio, or in each case in the form of a physiologically acceptable salt, or in each case in the form of a solvate, characterized in that a substituted 3-aryl-but-3-enyl-amine compound of the general formula III wherein R1, R2, R3, R4, R7, R8, R9, R10, R11, R12 and R13 have the abovementioned meaning, in each case optionally in the form of one of its pure stereoisomers, in particular enantiomers or diastereomers, its racemates or in the form of a mixture of stereoisomers, in particular the enantiomers or diastereomers, in any desired mixing ratio, or in each case in the form of a physiologically acceptable salt, or in each case in the form of a solvate, is hydrogenated with the participation of a metal catalyst and hydrogen to give a substituted 3-aryl-butyl-amine compound of the general formula I. It is particularly preferable for the part process according to the invention if, for compounds according to formula I and formula III, R4 is chosen from H or CH3, preferably R4 denotes H. It is particularly preferable for the part process according to the invention if, for compounds according to formula I and formula III, R1 is chosen from C1-3-alkyl, saturated or unsaturated, substituted or unsubstituted, branched or unbranched. It is particularly preferable for the part process according to the invention if, for compounds according to formula I and formula III, R4 is chosen from H or CH3, preferably R4 denotes H, and/or R1 is chosen from C1-3-alkyl, satiarated or unsaturated, substituted or unsubstituted, branched or unbranched. It is particularly preferable for the part process according to the invention if, for compounds according to formula I and formula III, R7 and R8 in each case independently of one another are chosen from H or CH3, preferably R7 and R8 denote H or R7 and R8 denote CH3 or R7 denotes H and R8 denotes CH3, in particular R7 and R8 denote CH3. It is particularly preferable for the part process according to the invention if, for compounds according to formula I and formula III, R1 is chosen from C1-3-alkyl, saturated and unsubstituted, branched or unbranched, preferably from CH3, C2H5, i-propyl or n-propyl, in particular from CH3 or C2H5. It is particularly preferable for the part process according to the invention if, for compounds according to formula I and formula III, R2 and R3 independently of one another are chosen from H, C1-4-alkyl, saturated and unsubstituted, branched or unbranched; preferably from H, CH3, C2H5, i-propyl or t-butyl, in particular from H or CH3 or C2H5. It is particularly preferable for the part process according to the invention if, for compounds according to formula I and formula III, R3 = H and R2 ? H, preferably R3 = H and R2 = CH3 or C2H5, in particular R3 = H and R2 = CH3. It is particularly preferable for the part process according to the invention if, for compounds according to formula I and formula III, R2 and R3 together form a C5-6-cycloalkyl radical, saturated or unsaturated, unsubstituted or raono- or polysubstituted, preferably saturated and unsubstituted, in particular cyclohexyl. It is particularly preferable for the part process according to the invention if, for compounds according to formula I and formula III, R9 to R13, where 3 or 4 of the radicals R9 to R13 must correspond to H, independently of one another are chosen from H, Cl, F, OH, CF2H, CF3 or C1-4-alkyl, saturated and unsubstituted, branched or unbranched; OR14 or SR14, where R14 is chosen from C1-3-alkyl, saturated and unsubstituted, branched or unbranched; preferably from H, Cl, F, OH, CF2H, CF3, OCH3 or SCH3 or R12 and R11 form a 3,4-OCH=CH ring in particular if R9, R11 and R13 correspond to H, one of R10 or R12 also corresponds to H, while the other is chosen from: Cl, F, OH, CF2H, CF3, OR14 or SR14, preferably from OH, CF2H, OCH3 or SCH3 or if R9 and R13 correspond to H and R11 corresponds to OH, OCH3, Cl or F, preferably Cl, one of R10 or R12 also corresponds to H, while the other corresponds to OH, OCH3, Cl or F, preferably Cl, or if R9, R10, R12 and R13 correspond to H, R11 is chosen from CF3, CF2H, Cl or F, preferably from F, or if R10, R11 and R12 correspond to H, one of R9 or R13 also corresponds to H, while the other is chosen from OH, OC2H5 or OC3H7. It is particularly preferable for the part process according to the invention if, for compounds according to formula I and formula III, R1 is chosen from Ci-3-alkyl, saturated and unsubstituted, branched or unbranched; preferably CH3, C2H5, or C3H7, in particular CH3 or C2H5, and/or R2 and R3 independently of one another are chosen from H, C1-4-alkyl, saturated and unsubstituted, branched or unbranched; preferably from H, CH3, C2H5, i-propyl or t-butyl, in particular from H or CH3 or C2H5, preferably: R3 = H and R2 ? H, preferably R3 = H and R2 = CH3 or C2H5, in particular R3 = H and R2 = CH3, or R2 and R3 together form a C5-6-cycloalkyl radical, saturated or unsaturated, unsubstituted or mono- or polysubstituted, preferably saturated and unsubstituted, in particular cyclohexyl, and/or R4 is chosen from H, and/or R7 and R8 in each case independently of one another are chosen from H or CH3/ preferably R7 and R8 denote H or R7 and R8 denote CH3 or R7 denotes H and R8 denotes CH3, in particular R7 and R8 denote CH3; and/or R9 to R13, where 3 or 4 of the radicals R9 to R13 must correspond to H, independently of one another are chosen from H, Cl, F, OH, CF2H, CF3 or Ci-4-alkyl, saturated and unsubstituted, branched or unbranched; OR14 or SR14, where R14 is chosen from C1-3-alkyl, saturated and unsubstituted, branched or unbranched; preferably from H, Cl, F, OH, CF2H, CF3, OCH3 or SCH3 or R12 and R11 form a 3,4-OCH=CH ring in particular if R9, R11 and R13 correspond to H, one of R10 or R12 also corresponds to H, while the other is chosen from: Cl, F, OH, CF2H, CF3, OR14 or SR14, preferably from OH, CF2H, OCH3 or SCH3 or if R9 and R13 correspond to H and R11 corresponds to OH, OCH3, Cl or F, preferably Cl, one of R10 or R12 also corresponds to H, while the other corresponds to OH, OCH3, Cl or F, preferably Cl, or if R9, R10, R12 and R13 correspond to H, R11 is chosen from CF3, CF2H, Cl or F, preferably from F, or if R10, R11 and R12 correspond to H, one of R9 or R13 also corresponds to H, while the other is chosen from OH, OC2H5 or OC3H7. It is particularly preferable for the part process according to the invention if, for compounds according to formula I where R3 = H and R2 ? H, these are in the configurations Ia or Ib It is particularly preferable for the part process according to the invention if, for compounds according to formula III where R3 = H, R2 ? H, R4 = H and R1 ? H, these are in the configurations IIIa or IIIb or for compounds according to formula III where R3 = H, R2 ? H, R4 = H and R1 ? H, these are in the configurations IIIc or IIId It is particularly preferable for the part process according to the invention if, for the compound/compounds according to formula I, at least one of these, preferably as the free base or as the hydrochloride, is chosen from the following group: ¦ 3-(3-dimethylamino-l-ethyl-2-methyl-propyl)- phenol, ¦ (1R,2R)-3-(3-dimethylamino-l-ethyl-2-methyl- propyl)-phenol ¦ (-) - (1R,2R) -3- (3-dimethylami.no-1-ethyl-2-methyl - propyl)-phenol, ¦ (1S,2S)-3-(3-dimethylamino-l-ethyl-2-methyl- propyl)-phenol ¦ ( + )- (1S,2S)-3-(3-dimethylamino-l-ethyl-2-methyl- propyl)-phenol ¦ (±)-(1RS,2RS)-3-(3-dimethylamino-l-ethyl-2- methyl-propyl)-phenol ¦ rac-(1RS,2RS)-3-(3-dimethylamino-l-ethyl-2- methyl-propyl)-phenol, ¦ [3-(3-methoxy-phenyl)-2-methyl-pentyl]- dimethylamine, ¦ (2R,3R)-[3-(3-methoxy-phenyl)-2-methyl-pentyl]- dimethylamine, ¦ (-)-(2R,3R)-[3-(3-methoxy-phenyl)-2-methyl- pentyl]-dimethylamine, ¦ (2S,3S)-[3-(3-methoxy-phenyl)-2-methyl-pentyl]- dimethylamine, ¦ (+)-(2S,3S)-[3-(3-methoxy-phenyl)-2-methyl- pentyl]-dimethylamine, ¦ (±)-(2RS,3RS)-[3-(3-methoxy-phenyl)-2-methyl- pentyl]-dimethylamine, ¦ rac(2RS,3RS)-[3-(3-methoxy-phenyl)-2-methyl- pentyl]-dimethylamine, ¦ 3{ [3-(p-isopropyl-phenyl-carbamoyl)-oxy-phenyl]- 2-methyl-pentyl}-dimethylamine, ¦ (2R,3R)-{3[3-(p-isopropyl-phenyl-carbamoyl)-oxy- phenyl] -2-methyl-pentyl}-dimethylamine, ¦ (2S,3S)-{3[3-(p-isopropyl-phenyl-carbamoyl)-oxy- phenyl] -2-methyl-pentyl}-dimethylamine, ¦ (2SR,3SR)-{3[3-(p-isopropyl-phenyl-carbamoyl)- oxy-phenyl]-2-methyl-pentyl}-dimethylamine preferably ¦ 3-(3-dimethylamino-l-ethyl-2-methyl-propyl)- phenol, ¦ (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl- propyl)-phenol, ¦ (-)-(1R,2R)-3-(3-dimethylamino-l-ethyl-2-methyl- propyl)-phenol, ¦ (1S,2S)-3-(3-dimethylamino-l-ethyl-2-methyl- propyl)-phenol, ¦ ( + ) -(1S, 2S) -3-(3-dimethylamino-l-ethyl-2-methyl- propyl)-phenol, ¦ (±)-(1RS,2RS)-3-(3-dimethylamino-1-ethyl-2- methyl-propyl)-phenol, ¦ rac-(1RS,2RS)-3-(3-dimethylamino-l-ethyl-2- methyl-propyl)-phenol, ¦ [3-(3-methoxy-phenyl)-2-methyl-pentyl] - dimethylamine, ¦ (2R,3R)-[3-(3-methoxy-phenyl)-2-methyl-pentyl]- dimethylamine, ¦ (-)-(2R,3R)-[3-(3-methoxy-phenyl)-2-methyl- pentyl]-dimethylamine, ¦ (2S,3S)- [3-(3-methoxy-phenyl)-2-methyl-pentyl]- dimethylamine, ¦ (+)-(2S,3S)-[3-(3-methoxy-phenyl)-2-methyl- pentyl]-dimethylamine, in particular ¦ [3-(3-methoxy-phenyl)-2-methyl-pentyl] - dimethylamine, ¦ (2R,3R)-[3-(3-methoxy-phenyl)-2-methyl-pentyl]- dimethylamine, ¦ (-)-(2R,3R)-[3-(3-methoxy-phenyl)-2-methyl- pentyl]-dimethylamine, ¦ (2S,3S)-[3-(3-methoxy-phenyl)-2-methyl-pentyl]- dimethylamine, ¦ (+)-(2S,3S)-[3-(3-methoxy-phenyl)-2-methyl- pentyl]-dimethylamine. It is particularly preferable for the part process according to the invention if, for the compound/compounds according to formula III employed, at least one of these, preferably as the free base or as the hydrochloride, is chosen from the following group: ¦ 3-(3-dimethylamino-l-ethenyl-2-methyl-propyl)- phenol, ¦ (Z)-(2R)-3-{3-dimethylamino-1-ethenyl-2-methyl- propyl)-phenol, ¦ (E)-(2R)-3-(3-dimethylamino-l-ethenyl-2-methyl- propyl)-phenol, ¦ (Z,E)-(2R)-3-(3-dimethylamino-l-ethenyl-2-methyl- propyl)-phenol, ¦ (Z)-(2S)-3-(3-dimethylamino-l-ethenyl-2-methyl- propyl)-phenol, ¦ (E)-(2S)-(3-dimethylamino-l-ethenyl-2-methyl- propyl)-phenol, ¦ (Z,E)-(2S)-3-(3-dimethylamino-l-ethenyl-2-methyl- propyl)-phenol, ¦ [3-(3-methoxy-phenyl)-2-methyl-pent-3-enyl]- dimethylamine, ¦ (Z)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (E)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (Z,E)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3 - enyl]-dimethylamine, ¦ (Z)-(2S)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (E)-(2S)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (Z,E)-(2S)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ {3 [3-(p-isopropyl-phenyl-carbamoyl)-oxy-phenyl] - 2-methyl-pent-3-enyl}-dimethylamine, ¦ (Z)-(2R)-{3[3-(p-isopropyl-phenyl-carbamoyl)-oxy- phenyl] -2-methyl-pent-3-enyl}-dimethylamine, ¦ (E)-(2R)-{3[3-(p-isopropyl-phenyl-carbamoyl)-oxy- phenyl]-2-methyl-pent -3 -enyl}-dimethylamine, ¦ (Z,E)-(2R)-{3[3-(p-isopropyl-phenyl-carbamoyl)- oxy-phenyl]-2-methyl-pent-3-enyl}-dimethylamine, ¦ (Z)-(2S)-{3[3-(p-isopropyl-phenyl-carbamoyl)-oxy- phenyl] -2-methyl-pent-3-enyl}-dimethylamine, ¦ (E)-(2S)-{3[3-(p-isopropyl-phenyl-carbamoyl)-oxy- phenyl] -2-methyl-pent-3-enyl}-dimethylamine, ¦ (Z,E)-(2S)-{3[3-(p-isopropyl-phenyl-carbamoyl)- oxy-phenyl]-2-methyl-pent-3-enyl}-dimethylamine, preferably ¦ 3-(3-dimethylamino-l-ethenyl-2-methyl-propyl)- phenol, ¦ (Z)-(2R)-3-(3-dimethylamino~l-ethenyl-2-methyl- propyl)-phenol, ¦ (E)-(2R)-3-(3-dimethylamino-l-ethenyl-2-methyl- propyl)-phenol, ¦ (Z,E)-(2R)-3-(3-dimethylamino-l-ethenyl-2-methyl- propyl)-phenol, ¦ (Z)-(2S)-3-(3-dimethylamino-l-ethenyl-2-methyl- propyl)-phenol, ¦ (E)-(2S)-(3-dimethylamino-l-ethenyl-2-methyl- propyl)-phenol, ¦ (Z,E)-(2S)-3-(3-dimethylamino-l-ethenyl-2-methyl- propyl)-phenol, ¦ [3-(3-methoxy-phenyl)-2-methyl-pent-3-enyl]- dimethylamine, ¦ (Z)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (E)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (Z,E)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (Z)-(2S)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (E)-(2S)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (Z,E)-(2S)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, in particular ¦ [3-(3-methoxy-phenyl)-2-methyl-pent-3-enyl]- dimethylamine, ¦ (Z)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (E)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (Z,E)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (Z)-(2S)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, " (E)-(2S)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (Z,E)-(2S)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, preferably ¦ (Z)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (E)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine or ¦ (Z,E)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, or ¦ (Z)-(2S)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (E)-(2S)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl}-dimethylamine or ¦ (Z,E)- (2S)- [3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine. It is particularly preferable for the part process according to the invention if a chiral centre is present in the compound according to formula III employed, at position 2 according to formula III. It is particularly preferable for the part process according to the invention if a chiral centre is present in the compound according to formula I, at position 2 according to formula I. It is particularly preferable for the part process according to the invention if the compound according to formula III employed is enantiomerically pure. It is particularly preferable for the part process according to the invention if the compound according to formula III employed is diastereomerically pure. It is particularly preferable for the part process according to the invention if the compound according to formula III employed is enantiomerically and diastereomerically pure. It is particularly preferable for the part process according to the invention if the compound according to formula III employed is chosen from: • (Z)-(2R)-[3-(3-methoxy-phenyl)-2-methyl- pent-3-enyl]-dimethylamine, • (E)-(2R)-[3-(3-methoxy-phenyl)-2-methyl- pent-3-enyl]-dimethylamine or is a mixture of (Z)-(2R)-[3-(3-methoxy-phenyl)-2- methyl-pent-3-enyl]-dimethylamine and (E)-(2R)- [3-(3- methoxy-phenyl)-2-methyl-pent-3-enyl]-dimethylamine, or (Z,E)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine. It is particularly preferable for the part process according to the invention if the compound according to formula III employed is chosen from: • (Z)-(2S)-[3-(3-methoxy-phenyl)-2-methyl- pent-3-enyl]-dimethylamine, • (E)-(2S)-[3-(3-methoxy-phenyl)-2-methyl- pent-3-enyl]-dimethylamine or is a mixture of (Z)-(2S)-[3-(3-methoxy-phenyl)-2- methyl-pent-3-enyl]-dimethylamine and (E)-(2S)- [3-(3- methoxy-phenyl)-2-methyl-pent-3-enyl]-dimethylamine, or (Z,E)-(2S)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine. It is particularly preferable for the part process according to the invention if the solvent is chosen from: H20 or alcohol or aqueous alcoholic or aqueous acidic solutions, preferably from aqueous acidic solutions. It is particularly preferable for the part process according to the invention if the solvent is chosen from: H20 or ethanol or aqueous ethanolic solution or aqueous hydrochloric acid, preferably from aqueous hydrochloric acid. It is particularly preferable for the part process according to the invention if the catalyst used comprises a noble metal, preferably platinum, gold or palladium, in particular palladium. It is particularly preferable for the part process according to the invention if the catalyst used is palladium-on-active charcoal or palladium(II) chloride. It is particularly preferable for the part process according to the invention if the catalyst used is palladium-on-active charcoal (1 - 10 wt.%, preferably 5 wt.%). It is particularly preferable for the part process according to the invention if the temperature is kept between 2 0 and 4 0°C, preferably between 2 0 and 35, in particular 25°C. It is preferable for the process according to the invention if, in step b), an inert gas atmosphere, in particular a nitrogen inert gas, is applied before the hydrogenation. It is particularly preferable for the part process according to the invention if the hydrogenation takes place under a hydrogen pre-pressure of 3-10 bar, preferably 4- 7 bar, in particular 5 bar and/or the hydrogenation step takes place under a hydrogen internal pressure of 0.5-3 bar, preferably 0.75-2 bar, in particular 1 bar. It is particularly preferable for the part process according to the invention if the starting substances are highly dilute/diluted in the solvent at the start. It is particularly preferable for the part process according to the invention if the compound according to formula III employed is dissolved in aqueous acid. It is particularly preferable for the part process according to the invention if the compound according to formula III employed is dissolved in aqueous hydrochloric acid. It is particularly preferable both for the process according to the invention and for the part process according to the invention if the products are precipitated in an organic solvent at the end of the process. It is particularly preferable both for the process according to the invention and for the part process according to the invention if the products are precipitated with acid or acid gas, preferably hydrochloric acid or hydrochloric acid gas, in particular hydrochloric acid gas, at the end of the process. It is particularly preferable both for the process according to the invention and for the part process according to the invention if the products are precipitated in an organic solvent with acid or acid gas, preferably hydrochloric acid or hydrochloric acid gas, in particular hydrochloric acid gas, at the end of the process. General: The elimination step (step a) of the process according to the invention It has been found that in step a) of the process according to the invention formic acid, hydrochloric acid and hydrobromic acid are very particularly suitable for eliminating the tertiary OH group and achieving high yields. If a chiral centre is adjacent to the OH group, it is necessary to carry out the elimination regioselectively in order to prevent the chiral information from being lost. This is achieved astonishingly very well by the use of formic acid, hydrochloric acid and hydrobromic acid. In particular, the use of inexpensive hydrochloric acid, which can be converted into sodium chloride by neutralization after the end of the reaction, is preferred in this process. The regioselectivity of the elimination can be further influenced in a positive manner by modification of the reaction time, reaction temperature and concentration of the acid. High concentrations of the acid increasingly lead to the desired compounds. Particularly suitable reaction conditions are 36% hydrochloric acid over a reaction time of 5 hours and at a temperature of 55°C. The Z isomers are obtained in good yields by crystallization of the compounds which have undergone elimination using hydrochloric acid gas in solvents. Small amounts of (Z,E)-dimethyl-(3-aryl-pent-2-enyl)-amine compounds, which are not desirable for this process, remain in solution or can be depleted by recrystallization. The hydrogenation step (step b) in the process according to the invention and part process according to the invention This part process or step b) is of interest for compounds which have a chiral centre in the vicinity of the OH group. As is described above in the elimination step, it is possible to control the elimination such that the chiral centre is involved in the elimination to only a small extent. By crystallization of the compounds which have undergone elimination, the (Z,E)-dimethyl-(3-aryl-pent-2- enyl)-amine compounds are depleted, so that no racemization on the adjacent C atom to the OH group can occur after the hydrogenation. Astonishingly, the (Z,E)-dimethyl-(3-aryl-pent-2-enyl)- amine compounds cannot be hydrogenated on the double bond under the hydrogenation conditions described in this process, rather a loss of the dimethylamino group with secondary hydrogenations occurs in a first reaction. For this reason it is possible to employ products which have undergone elimination in the hydrogenation without purification. Residual amounts of (Z,E)-dimethyl-(3-aryl- pent-2-enyl)-amine compounds contained in the crude products of the elimination are subjected to splitting off of dimethylamine during the elimination. During the precipitation of the hydrogenated compounds with hydrochloric acid gas in organic solvents, the deaminated compounds cannot form salts, and therefore remain dissolved in the organic mother liquor. As a result, astonishingly also no racemization can then occur, even if the starting substances for the hydrogenation step still contain residues of (Z,E)- dimethyl-(3-aryl-pent-2-enyl)-amine compounds. The first hydrogenation was carried out in ethanol with the addition of palladium/C 10% and astonishingly a diastereomer ratio of 70:30 in favour of the diastereomers desired in this process, the (R,R)-(3-aryl-2-methyl- pentyl)-amines, was obtained. It was found that at a high dilution of the starting substances in the solvent, the content of the desired diastereomer increases further up to 90%. Astonishingly, by slow addition of the double bond component into the solvent, which has been initially introduced into the reaction vessel, with catalyst and hydrogen, a diastereomer concentration of 75% can be achieved. An addition of catalytic amounts of hydrochloric acid also produces an increase in the desired diastereomer to 85% at a lower dilution. The combination of dilution and acidification with aqueous hydrochloric acid produces an increase in the desired diastereomer to 90%. In addition to palladium, palladium chloride can also be employed. Here also, the desired product is obtained in a good yield with a diastereomer excess of 70%. This process has the great advantage that the palladium obtained can be dissolved again in nitric acid after the hydrogenation and can be employed in the next hydrogenation almost without loss. Combination of the two processes (process according to the invention) It was particularly astonishing and satisfying that the elimination and hydrogenation can be carried out in a one- pot process. Astonishingly, studies showed that the Z,E ratio of the (Z,E)-(2RS)-dimethyl-(3-aryl-2-methyl-pent-3-enyl)-amine compounds has no influence on the diastereomer ratio of the hydrogenated end products. It was therefore not necessary to isolate the pure Z products, which had undergone elimination, by crystallization. The elimination was first carried out in aqueous hydrochloric acid, the palladium catalyst was subsequently added and the hydrogenation was then carried out. The desired (R,R)-diastereomer is obtained in an amount of 73%. The invention is explained in the following with the aid of examples. These explanations are merely by way of example and do not limit the general inventive idea. EXAMPLES Example 1: 15 kg (59.7 mol) (2S,3S)-1-dimethylamino-3-(3-methoxy- phenyl)-2-methyl-pentan-3-ol were initially introduced into a 100 1 double-walled reaction unit with an electrical anchor stirrer, PtlOO temperature-measuring device and oil- based cooling/heating system at 20°C and a stirring speed of 100 rpm, and 26.25 1 36 wt.% (308 mol) aqueous hydrochloric acid were added in the course of 10 min. The reaction mixture was heated to 50CC in the course of 2 0 min and stirred at this temperature for 4-6 hours. Thereafter, the mixture was cooled to 25°C and diluted with 13 1 water. Approx. 32 1 32 wt.% (256 mol) sodium hydroxide solution were added at an internal temperature of 20°C, while cooling with a jacket temperature of 5°C, until a pH of 10 - 12.5 was reached. Thereafter, 22.5 1 ethyl acetate were added and, after 10 min under stirring, the stirrer was switched off for the phase separation. The lower aqueous phase was drained off and the upper oirganic phase was distilled off at a maximum internal temperature of 50°C under a vacuum to 10 mbar. The pale yellow oily residue which remained is the desired (Z,E)-(2R)-[3-(3-methoxy- phenyl)-2-methyl-pent-3-enyl]-dimethyl-amine. The yield is 13.6 kg (98% of theory) with an HPLC purity of 90% and a Z/E ratio of 70:30. Example 2: 15 kg (52.15 mol) (2S,3S)-1-dimethylamino-3-(3-methoxy- phenyl)-2-methyl-pentan-3-ol hydrochloride were initially introduced into a 100 1 double-walled reaction unit with an electrical anchor stirrer, PtlOO temperature-measuring device and oil-based cooling/heating system at 20°C and a stirring speed of 100 rpm, and 26.25 1 36 wt.% (308 mol) aqueous hydrochloric acid were added in the course of 10 min. The reaction mixture was heated to 50°C in the course of 20 min and stirred at this temperature for 4-6 hours. Thereafter, the mixture was cooled to 25°C and diluted with 13 1 water. Approx. 32 1 32 wt.% (256 mol) sodium hydroxide solution were added at an internal temperature of 20°C, while cooling with a jacket temperature of 5°C, until a pH of 10 - 12.5 was reached. Thereafter, 22.5 1 ethyl acetate were added and, after 10 min under stirring, the stirrer was switched off for the phase separation. The lower aqueous phase was drained off and the upper organic phase was distilled off at a maximum internal temperature of 50°C under a vacuum to 10 mbar. The pale yellow oily residue which remained is the desired (Z,E)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3-enyl]- dimethyl-amine. The yield is 11.9 kg (98% of theory) (54.4 mol) with an HPLC purity of 90% and a Z/E ratio of 70:30. Example 3: 15 kg (59.68 mol) of a 70:30 mixture of (2S,3S)-1- dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol and (2S,3R)-l-dimethylamino-3-(3-methoxy-phenyl)-2-methyl- pentan-3-ol were initially introduced into a 100 1 double- walled reaction unit with an electrical anchor stirrer, Pt100 temperature-measuring device and oil-based cooling/heating system at 20°C and a stirring speed of 100 rpm, and 26.25 1 36 wt.% (307.9 mol) aqueous hydrochloric acid were added in the course of 10 min. The reaction mixture was heated to 50°C in the course of 2 0 min and stirred at this temperature for 4-6 hours. Thereafter, the mixture was cooled to 25°C and diluted with 13 1 water. Approx. 32 1 32 wt.% sodium hydroxide solution (256 mol) were added at an internal temperature of 20°C, while cooling with a jacket temperature of 5°C, until a pH of 10 - 12.5 was reached. Thereafter, 22.5 1 ethyl acetate were added and, after 10 min under stirring, the stirrer was switched off for the phase separation. The lower aqueous phase was drained off and the upper organic phase was distilled off at a maximum internal temperature of 50°C under a vacuum to 10 mbar. The pale yellow oily residue which remained is the desired (Z,E)-(2R)-[3-(3-methoxy- phenyl) -2-methyl-pent-3-enyl] -dimethyl-amine. The yield is 13.6 kg (58.3 mol) (98% of theory) with an HPLC purity of 90% and a 2/E ratio of 70:30. Example 4: 15 kg (59.68 mol) of a mixture of (2S,3S)-1-dimethylamino- 3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol (35 wt.%), (2R,3R)-l-dimethylamino-3-(3-methoxy-phenyl)-2-methyl- pentan-3-ol (35 wt.%), (2R,3S)-l-dimethylamino-3-(3- methoxy-phenyl)-2-methyl-pentan-3-ol (15 wt.%) and (2S,3R)- l-dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol (15 wt.%) were initially introduced into a 100 1 double- walled reaction unit with an electrical anchor stirrer, PtlOO temperature-measuring device and oil-based cooling/heating system at 20°C and a stirring speed of 100 rpm, and 26.25 1 36 wt.% aqueous hydrochloric acid were added in the course of 10 min. The reaction mixture was heated to 50°C in the course of 20 min and stirred at this temperature for 4-6 hours. Thereafter, the mixture was cooled to 25°C and diluted with 13 1 water. Approx. 32 1 32 wt.% sodium hydroxide solution were added at an internal temperature of 20°C, while cooling with a jacket temperature of 5°C, until a pH of 10 - 12.5 was reached. Thereafter, 22.5 1 ethyl acetate were added and, after 10 min under stirring, the stirrer was switched off for the phase separation. The lower aqueous phase was drained off and the upper organic phase was distilled off at a maximum internal temperature of 50°C under a vacuum to 10 mbar. The pale yellow oily residue which remained is the desired mixture of (Z,E)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent- 3-enyl]-dimethyl-amine and (Z,E)-(2S)-[3-(3-methoxy- phenyl)-2-methyl-pent-3-enyl]-dimethyl-amine. The yield is 13.6 kg (98% of theory) with an HPLC purity of 90% and a Z/E ratio of 70:30. Example 5: 28.7 g (o.l mol) (2S,3S)-l-dimethylamino-3-(3-methoxy- phenyl)-2-methyl-pentan-3-ol hydrochloride were initially introduced into a 250 ml three-necked flask with a thermometer, mechanical compressed air stirrer, reflux condenser and oil bath heating, and 150 ml formic acid were added. The mixture was boiled under reflux for 4 hours. It was cooled and poured into a 500 ml round-bottomed flask and the formic acid was distilled off on a Buchi 5 1 rotary evaporator at 60°C to a pressure of 10 mbar. 150 ml ethyl acetate and 100 ml water were added to the oily residue. A pH of 11 was established with 33 wt.% sodium hydroxide solution, the phases were separated and the ethyl acetate was distilled off on a rotary evaporator at 60°C to a pressure of 10 mbar. The oily residue consists of (Z,E)- (2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3-enyl]-dimethyl- amine with a GC purity of 92%, a Z/E ratio of 2.2:1 and a yield of 21.0 g (90% of theory). In the purity analysis, 0.37% of unreacted starting substance and 2.01% of (Z,E)- [3-(3-methoxy-phenyl)-2-methyl-pent-2-enyl]-dimethyl-amine hydrochloride were also found. Example 6: 28.7 g (0.1 mol) (2S,3S)-l-dimethylamino-3-(3-methoxy- phenyl) -2-methyl-pentan-3-ol hydrochloride were initially introduced into a 250 ml three-necked flask with a thermometer, mechanical compressed air stirrer, reflux condenser and oil bath heating, and 75 ml 47 wt.% hydrobromic acid were added. The mixture was heated at 50°C for 1 hour. It was cooled to 20°C and a pH of 11 was established with 33 wt.% sodium hydroxide solution at 20°C, while cooling. 150 ml ethyl acetate were added, the mixture was stirred for 10 min, the. stirrer was switched off, the phases were separated and the ethyl acetate was distilled off on a rotary evaporator at 60°C to a pressure of 10 mbar. The oily residue consists of (Z, E) - (2R) - [3-(3- methoxy-phenyl)-2-methyl-pent-3-enyl]-dimethyl-amine with a GC purity of 93%, a Z/E ratio of 4:1 and a yield of 21 g (90% of theory). In the purity analysis, 1.52% of unreacted starting substance and 2.1% of (Z,E)-[3-(3- methoxy-phenyl)-2-methyl-pent-2-enyl]-dimethyl-amine hydrochloride were also found. Example 7: 28.7 g (0.1 mol) (2R,3R)-l-dimethylamino-3-(3-methoxy- phenyl)-2-methyl-pentan-3-ol hydrochloride were initially introduced into a 250 ml three-necked flask with a thermometer, mechanical compressed air stirrer, reflux condenser and oil bath heating, and 75 ml 47 wt.% hydrobromic acid were added. The mixture was heated at 35°C for 4 hours. It was cooled to 20°C and a pH of 11 was established with 33 wt.% sodium hydroxide solution at 20°C, while cooling. 150 ml ethyl acetate were added, the mixture was stirred for 10 min, the stirrer was switched off, the phases were separated and the ethyl acetate was distilled off on a rotary evaporator at 60°C to a pressure of 10 mbar. The oily residue consists of (Z,E)- (2S)- [3- (3- methoxy-phenyl)-2-methyl-pent-3-enyl]-dimethyl-amine with a GC purity of 90.5%, a Z/E ratio of 2.9:1 and a yield of 21 g (90% of theory) . In the purity analysis, 4.92% of unreacted starting substance and 1.5% of (Z,E)-[3-(3~ methoxy-phenyl)-2-methyl-pent-2-enyl]-dimethyl-amine hydrochloride were also found. Example 8: 28.7 g (0.1 mol) (2R,3R)-l-dimethylamino-3-(3-methoxy- phenyl)-2-methyl-pentan-3-ol hydrochloride were initially introduced into a 250 ml three-necked flask with a thermometer, mechanical compressed air stirrer, reflux condenser and oil bath heating, and 75 ml 47 wt.% hydrobromic acid were added. The mixture was heated at 35°C for 4 hours. It was cooled to 20°C and a pH of 11 was established with 33 wt.% sodium hydroxide solution at 20°C, while cooling. 150 ml ethyl acetate were added, the mixture was stirred for 10 min, the stirrer was switched off, the phases were separated and the ethyl acetate was distilled off on a rotary evaporator at 60°C to a pressure of 10 mbar. The oily residue consists of (Z,E)- (2S)- [3-(3- methoxy-phenyl)-2-methyl-pent-3-enyl]-dimethyl-amine with a GC purity of 90.5%, a Z/E ratio of 2.9:1 and a yield of 21 g (90% of theory). In the purity analysis, 4.92% of unreacted starting substance and 1.5% of (Z,E)-[3-(3- methoxy-phenyl)-2-methyl-pent-2-enyl]-dimethyl-amine hydrochloride were also found. Example 9: 28.7 g (0.1 mol) (2S,3R)-l-dimethylamino-3-(3-methoxy- phenyl)-2-methyl-pentan-3-ol hydrochloride were initially introduced into a 250 ml three-necked flask with a thermometer, mechanical compressed air stirrer, reflux condenser and oil bath heating, and 150 ml aqueous 36 wt.% hydrochloric acid were added. The mixture was heated at 55°C for 19 hours. It was cooled to 20°C and a pH of 11 was established with 33 wt.% sodium hydroxide solution at 20°C, while cooling. 150 ml ethyl acetate were added, the mixture was stirred for 10 min, the stirrer was switched off, the phases were separated and the ethyl acetate was distilled off on a rotary evaporator at 60°C to a pressure of 10 mbar. The oily residue consists of (Z,E)-(2R)-[3-(3- methoxy-phenyl)-2-methyl-pent-3-enyl]-dimethyl-amine with a GC purity of 40%, a Z/E ratio of 3.5:1 and a yield of 21 g (90% of theory). In the purity analysis, no starting substance and 40% of (Z,E)-[3-(3-methoxy-phenyl)-2-methyl- pent-2-enyl]-dimethyl-amine was found. Example 10: 28.7 g (0.1 mol) (2S,3R)-1-dimethylamino-3-(3-methoxy- phenyl) -2 -methyl-pentan-3-ol hydrochloride were initially introduced into a 250 ml three-necked flask with a thermometer, mechanical compressed air stirrer, reflux condenser and oil bath heating, and 150 ml aqueous 3 6 wt.% hydrochloric acid were added. The mixture was heated at 100°C for 1 hour. It was cooled to 20°C and a pH of 11 was established with 33 wt.% sodium hydroxide solution at 20°C, while cooling. 150 ml ethyl acetate were added, the mixture was stirred for 10 min, the stirrer was switched off, the phases were separated and the ethyl acetate was distilled off on a rotary evaporator at 60°C to a pressure of 10 mbar. The oily residue consists of (Z, E) - (2R) - [3-(3- methoxy-phenyl)-2-methyl-pent-3-enyl3-dimethyl-amine with a GC purity of 86%, a Z/E ratio of 6.5:1 and a yield of 21 g (90% of theory). In the purity analysis, no starting substance and 8.5% of (Z,E)~[3-(3-methoxy-phenyl)-2-methyl- pent-2-enyl]-dimethyl-amine was found. Example 11 10 kg (42.85 mol) (Z,E)-(2R)-[3-(3-methoxy-phenyl)-2- methyl-pent-3-enyl]-dimethyl-amine were dissolved in 25 1 ethanol abs. denat. in a coolable and heatable 50 1 double- walled hydrogenation apparatus with a permanently attached cover plate with a hydrogen and nitrogen feed, electrical gassing stirrer, baffle, PT 100 temperature-measuring device, inspection glass, hand hole and "Buchi bpc" gas controller at 25°C and a stirrer speed of 850 ± 150 rpm. The reaction unit was rendered inert with nitrogen. A suspension of 750 g palladium-on-active charcoal (5 wt.%) in 5 1 ethanol was added to the solution under nitrogen as an inert gas. After the reaction unit had been rendered inert again, hydrogenation was carried out with a hydrogen pre-pressure of 5 bar and an internal pressure of 1 bar until the uptake of hydrogen had ended. When the reaction had ended the unit was rendered inert again with nitrogen and the reaction mixture was filtered over a single-layer filter covered with filter earth in order to remove the catalyst. The clear filtrate was concentrated to constant weight on a rotary evaporator under a continuously reduced pressure. The clear oil which remains is a mixture of the desired (2R,3R)-[3-(3-methoxy-phenyl)-2-methyl- pentyl]dimethylamine and (2R,3S)-[3-(3-methoxy-phenyl)-2- methyl-pentyl]dimethylamine. The yield is 9.96 kg (42.3 mol) (99% of theory) with a GC purity of 90%. The diastereomer ratio (R,R enantiomer to R,S enantiomer) is 2.8:1. Example 12 0.8 kg (3.43 mol) (Z,E)-(2R)-[3-(3-methoxy-phenyl)-2- methyl-pent-3-enyl]-dimethyl-amine was dissolved in 25 1 ethanol abs. denat. in a coolable and heatable 50 1 double- walled hydrogenation apparatus with a permanently attached cover plate with a hydrogen and nitrogen feed, electrical gassing stirrer, baffle, PT 100 temperature-measuring device, inspection glass, hand hole and "Büchi bpc" gas controller at 25°C and a stirrer speed of 850 ± 150 rpm. The reaction unit was rendered inert with nitrogen. A suspension of 60 g palladium-on-active charcoal (5 wt.%) in 5 1 ethanol was added to the solution under nitrogen as an inert gas. After the reaction unit had been rendered inert again, hydrogenation was carried out with a hydrogen pre- pressure of 5 bar and an internal pressure of 1 bar until the uptake of hydrogen had ended. When the reaction had ended the unit was rendered inert again with nitrogen and the reaction mixture was filtered over a single-layer filter covered with filter earth in order to remove the catalyst. The clear filtrate was concentrated to constant weight on a rotary evaporator under a continuously reduced pressure. The clear oil which remained was a mixture of the desired (2R,3R)-[3-(3-methoxy-phenyl)-2-methyl- pentyljdimethylamine and (2R,3S)-[3-(3-methoxy-phenyl)-2- methyl-pentyl]dimethylamine. The yield is 0.80 kg (99% of theory) with a GC purity of 94%. The diastereomer ratio (R,R enantiomer to R,S enantiomer) is 5.9:1. Example 13: 5 kg (21.43 mol) (Z,E)-(2R)-[3-(3-methoxy-phenyl)-2-methyl- pent-3-enyl]-dimethyl-amine were dissolved in 13 1 ethanol abs. denat. in a coolable and heatable 50 1 double-walled hydrogenation apparatus with a permanently attached cover plate with a hydrogen and nitrogen feed, electrical gassing stirrer, baffle, PT 100 temperature-measuring device, inspection glass, hand hole and "Buchi bpc" gas controller at 25°C and a stirrer speed of 850 ± 150 rpm. The reaction unit was rendered inert with nitrogen. 375 g palladium-on-active charcoal (5 wt.%) were suspended in 0.675 kg 32 wt.% hydrochloric acid under nitrogen as an inert gas The catalyst suspension was added to the reaction solution, while stirring. After the reaction unit had been rendered inert again, hydrogenation was carried out with a hydrogen pre-pressure of 5 bar and an internal pressure of 1 bar until the uptake of hydrogen had ended. When the reaction had ended the unit was rendered inert with nitrogen and the reaction mixture was filtered over a single-layer filter covered with filter earth in order to remove the catalyst. The slightly cloudy filtrate was concentrated to constant weight on a rotary evaporator under a continuously reduced pressure. The white solid suspension which remained was taken up in 10 1 ethyl acetate, 3.7 1 10 wt.% sodium hydroxide solution were added at 20°C and a pH of 10 - 12 was established. The lower aqueous phase was separated off and discarded. The upper organic phase was concentrated to constant weight in a rotary evaporator at 45 - 50°C under a continuously reduced pressure. The clear oil which remains is a mixture of the desired (2R,3R)-[3-(3-methoxy-phenyl)-2-methyl- pentyl]dimethylamine and (2R,3S)-[3-(3-methoxy-phenyl)-2- methyl-pentyl]dimethylamine. The yield is 4.5 kg (90% of theory) with a GC purity of 90%. The diastereomer ratio (R,R enantiomer to R,S enantiomer) is 5.5:1 after isolation of the base. Example 14: 5 kg (21.43 mol) (Z,E)-(2R)-[3-(3-methoxy-phenyl)-2-methyl- pent-3-enyl]-dimethyl-amine were dissolved in 12.5 1 ethanol abs. denat. in a coolable and heatable 50 1 double- walled hydrogenation apparatus with a permanently attached cover plate with a hydrogen and nitrogen feed, electrical gassing stirrer, baffle, PT 100 temperature-measuring device, inspection glass, hand hole and "Büchi bpc" gas controller at 25°C and a stirrer speed of 850 ± 150 rpm. The reaction unit was rendered inert with nitrogen. A suspension of 1.87 g palladium-on-active charcoal (1 wt.%) in 2.5 1 ethanol and 630 g water was added to the solution under nitrogen as an inert gas. After the reaction unit had been rendered inert again, hydrogenation was carried out with a hydrogen pre-pressure of 5 bar and an internal pressure of 1 bar until the uptake of hydrogen had ended. When the reaction had ended the unit was rendered inert with nitrogen and the reaction mixture was filtered over a single-layer filter covered with filter earth in order to remove the catalyst. The clear filtrate was concentrated to constant weight on a rotary evaporator under a continuously reduced pressure. The clear oil which remains is a mixture of the desired (-)(2R,3R)-[3-(3-methoxy- phenyl) -2-methyl-pentyl] dimethylamine and (2R,3S) - [3-(3- methoxy-phenyl)-2-methyl-pentyl]dimethylamine. The yield is 4.90 kg (98% of theory) with a GC purity of 89%. The diastereomer ratio (R,R enantiomer to R,S enantiomer) is 2.7:1 after isolation of the base. Example 15 5 kg (21.43 mol) (Z,E)-(2R)-[3-(3-methoxy-phenyl)-2-methyl- pent-3-enyl]-dimethyl-amine were dissolved in 12.5 1 ethanol abs. denat. in a coolable and heatable 50 1 double- walled hydrogenation apparatus with a permanently attached cover plate with a hydrogen and nitrogen feed, electrical gassing stirrer, baffle, PT 100 temperature-measuring device, inspection glass, hand hole and "Büchi bpc" gas controller at 25°C and a stirrer speed of 850 ± 150 rpm. The reaction unit was rendered inert with nitrogen. A suspension of 0.19 kg palladium-on-active charcoal (10 wt.%) in 2.5 1 ethanol and 63 0 g water was added to the solution under nitrogen as an inert gas. After the reaction unit had been rendered inert again, hydrogenation was carried out with a hydrogen pre-pressure of 5 bar and an internal pressure of 1 bar until the uptake of hydrogen had ended. When the reaction had ended the unit was rendered inert with nitrogen and the reaction mixture was filtered over a single-layer filter covered with filter earth in order to remove the catalyst. The clear filtrate was concentrated to constant weight on a rotary evaporator under a continuously reduced pressure. The clear oil which remains is a mixture of the desired (2R, 3R)--[3-(3-methoxy-phenyl)- 2-methyl-pentyl]dimethylamine and (2R,3S)-[3-(3-methoxy- phenyl) -2 -methyl -pentyl] dimethylamine. The yield is 4.90 kg (98% of theory) with a GC purity of 87%. The diastereomer ratio (R,R enantiomer to R,S enantiomer) is 3.0:1 after isolation of the base. Example 16 5.76 kg (22.9 mol) (2S, 3R)-l-dimethylamino-3-(3-methoxy- phenyl) -2-methyl-pentan-3-ol were initially introduced into a 100 1 double-walled reaction unit with an electrical anchor stirrer, PtlOO temperature-measuring device and oil- based cooling/heating system at 20°C and a stirring speed of 100 rpm, and 12.22 1 3 6 wt.% aqueous hydrochloric acid were added in the course of 10 min. The reaction mixture was heated to 70°C in the course of 30 min and stirred at this temperature for 1 hour. The solution was then cooled to 20°C and 10 1 25 wt.% sodium hydroxide solution and 5 kg NaCl were added. A white suspension formed. The suspension was transferred to the hydrogenation apparatus. In a coolable and heatable 50 1 double-walled hydrogenation apparatus with a permanently attached cover plate with a hydrogen and nitrogen feed, electrical gassing stirrer, baffle, PT 100 temperature-measuring device, inspection glass, hand hole and "Büchi bpc" gas controller, a suspension of 0.230 kg palladium-on-active charcoal (1 wt.%) in 2.5 1 water was added to the suspension under nitrogen as an inert gas and the components were mixed at 25°C and a stirrer speed of 850 ± 150 rpm. The reaction unit was rendered inert with nitrogen. Hydrogenation was then carried out with a hydrogen pre-pressure of 5 bar and an internal pressure of 1 bar until the uptake of hydrogen had ended. When the reaction had ended the unit was rendered inert with nitrogen and the reaction mixture was filtered over a single-layer filter covered with filter earth in order to remove the catalyst. 18 1 32 wt.% sodium hydroxide solution were added to the clear filtrate and a pH of 11 - 12 was established, a precipitate occurring. tert-Butyl methyl ether was added and a phase separation was carried out. The organic phase was concentrated to constant weight on a rotary evaporator under a continuously reduced pressure. The clear oil which remains is a mixture of the desired (2R,3R)-[3-(3-methoxy-phenyl)-2-methyl- pentyl]dimethylamine and (2R,3S)-[3-(3-methoxy-phenyl)-2- methyl-pentyl]dimethylamine. The yield is 4.10 kg (76% of theory) with a GC purity of 90%. The diastereomer ratio (R,R enantiomer to R,S enantiomer) is 2.7:1 after isolation of the base. Example 17 5.42 kg (20 mol) (Z,E)-(2R)-[3 -(3-methoxy-phenyl)-2-methyl- pent-3-enyl]-dimethyl-amine hydrochloride were dissolved in 25 1 water in a coolable and heatable 50 1 double-walled hydrogenation apparatus with a permanently attached cover plate with a hydrogen and nitrogen feed, electrical gassing stirrer, baffle, PT 100 temperature-measuring device, inspection glass, hand hole and "Büchi bpc" gas controller at 45°C and a stirrer speed of 850 ± 150 rpm. The reaction unit was rendered inert with nitrogen. A suspension of 0.086 kg palladium-on-active charcoal (5 wt.%) in 2.5 1 water was added to the solution under nitrogen as an inert gas. After the reaction unit had been rendered inert again, hydrogenation was carried out with a hydrogen pre- pressure of 5 bar and an internal pressure of 1 bar until the uptake of hydrogen had ended. When the reaction had ended the unit was rendered inert with nitrogen and the reaction mixture was filtered over a single-layer filter covered with filter earth in order to remove the catalyst. 1.5 1 10 wt.% sodium hydroxide solution were added to the clear filtrate, a precipitate occurring. tert-Butyl methyl ether was added and a phase separation was carried out. The organic phase was concentrated to constant weight on a rotary evaporator under a continuously reduced pressure. The clear oil which remains is a mixture of the desired (2R,3R)-[3-(3-methoxy-phenyl)-2-methyl-pentyl]dimethylamine and (2R,3S)-[3-(3-methoxy-phenyl)-2-methyl- pentyl]dimethylamine. The yield is 4.10 kg (87% of theory) with a GC purity of 85%. The diastereomer ratio (R,R enantiomer to R,S enantiomer) is 2.6:1 after isolation of the base. Example 18 0.8 kg (3.44 mol) (Z,E)-(2R)-[3-(3-methoxy-phenyl)-2- methyl-pent-3-enyl]-dimethyl-amine were dissolved in 25 1 ethanol abs. denat. in a coolable and heatable 50 1 double- walled hydrogenation apparatus with a permanently attached cover plate with a hydrogen and nitrogen feed, electrical gassing stirrer, baffle, PT 100 temperature-measuring device, inspection glass, hand hole and "Büchi bpc" gas controller at 25°C and a stirrer speed of 850 ± 150 rpm. The reaction unit was rendered inert with nitrogen. 60 g palladium-on-active charcoal (5 wt.%) were suspended in 0.675 kg 32 wt.% hydrochloric acid under nitrogen as an inert gas. The catalyst suspension was added to the reaction solution, while stirring. After the reaction unit had been rendered inert again, hydrogenation was carried out with a hydrogen pre-pressure of 5 bar and an internal pressure of 1 bar until the uptake of hydrogen had ended. When the reaction had ended the unit was rendered inert again with nitrogen and the reaction mixture was filtered over a single-layer filter covered with filter earth in order to remove the catalyst. The clear filtrate was concentrated to constant weight on a rotary evaporator under a continuously reduced pressure. The clear oil which remained was a mixture of the desired (2R,3R)-[3-(3- methoxy-phenyl)-2-methyl-pentyl]dimethylamine and (2R,3S)- [3-(3-methoxy-phenyl)-2-methyl-pentyl]dimethylamine. The yield is 0.80 kg (99% of theory) with a GC purity of 94%. The diastereomer ratio (R,R enantiomer to R,S enantiomer) is 8.5:1. Example 19 5.76 kg (22.9 mol) (2S,3R)-1-dimethylamino-3-(3-methoxy- phenyl) -2-methyl-pentan-3-ol were initially introduced into a 100 1 double-walled reaction unit with an electrical anchor stirrer, PtlOO temperature-measuring device and oil- based cooling/heating system at 20°C and a stirring speed of 100 rpm, and 12.22 1 36 wt.% aqueous hydrochloric acid were added in the course of 10 min. The reaction mixture was heated to 70°C in the course of 30 min and stirred at this temperature for 1 hour. The solution was then cooled to 20°C and 10 1 25 wt.% sodium hydroxide solution and 5 kg NaCl were added. A white suspension formed. The suspension was transferred to the hydrogenation apparatus. In a coolable and heatable 50 1 double-walled hydrogenation apparatus with a permanently attached cover plate with a hydrogen and nitrogen feed, electrical gassing stirrer, baffle, PT 100 temperature-measuring device, inspection glass, hand hole and "Büchi bpc" gas controller, a solution of 0.288 kg palladium(II) chloride in 2.5 1 water was added to the suspension under nitrogen as an inert gas and the components were mixed at 25°C and a stirrer speed of 850 + 150 rpm. The reaction unit was rendered inert with nitrogen. Hydrogenation was then carried out with a hydrogen pre-pressure of 5 bar and an internal pressure of 1 bar until the uptake of hydrogen had ended. When the reaction had ended the unit, was rendered inert with nitrogen and the reaction mixture was filtered over a single-layer filter covered with filter earth in order to remove the catalyst. 18 1 32 wt.% sodium hydroxide solution were added to the clear filtrate and a pH of 11- 12 was established, a precipitate occurring. tert-Butyl methyl ether was added and a phase separation was carried out. The organic phase was concentrated to constant weight on a rotary evaporator under a continuously reduced pressure. The clear oil which remains is a mixture of the desired (2R,3R)-[3-(3-methoxy-phenyl)-2-methyl- pentyl]dimethylamine and (2R,3S)-[3-(3-methoxy-phenyl)-2- methyl-pentyl]dimethylamine. The yield is 4.10 kg (76% of theory) with a GC purity of 90%. The diastereomer ratio (R,R enantiomer to R,S enantiomer) is 10:1 after isolation of the base. Example 17: GC method for the analysis Sample preparation: tert-BME is added to the sample material. Hydrochlorides are liberated with Dowex MWA-1 to give the base. The clear organic phase is injected. Gas chromatography conditions: Capillary column : 6% cyanopropyl-phenyl- 94% dimethylpolysiloxane e.g. OPTIMA 1301-DF 1.0 (am; 30 m x 0.32 mm i.d. Carrier gas: : Helium Pre-pressure : 70 kPa; Split: 20 ml/min Oven temperature program .- Initial 160°C / 5 min Rate 5°C / min 190°C / 9 min Rate 10°C / min 150°C / 14 minutes Detector : FID Detector temperature : 260°C Injector temperature : 250°C We Claim: 1. Process for the preparation of a substituted 3-aryl-butyl-amine compound of the general formula I wherein R1 is chosen from H, C1-3-alkyl, branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted, R2 and R3 in each case independently of one another are chosen from H or C1-4-alkyl, branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstitued, R4 is chosen from H, C1-3-alkyl, branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted, R7 and R8 in each case independently of one another are chosen from H or C1-3-alkyl, branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted, R9 to R13, where 3 or 4 of the radicals R9 to R13 must correspond to H, independently of one another are chosen from H, Cl, F, OH, CF2H, CF3 or C1-4-alkyl, saturated and unsubstituted, branched or unbranched; OR14 or SR14, R14 is chosen from C1-3-alkyl, saturated and unsubstituted, branched or unbranched. where R17 and R18 in each case independently of one another are chosen from H; C1-6-alkyl, branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted; phenyl, benzyl or phenethyl, in each case unsubstituted or mono- or polysubstituted, or R9 and R10 or R10 and Ru together form an OCH2O, OCH2CH2O, OCH=CHO, CH=C(CH3)O, OC(CH3)=CH, (CH2)4 or OCH=CHO ring, in each case in the form of one of its pure stereoisomers, in particular enantiomers or diastereomers, its racemates or in the form of a mixture of stereoisomers, in particular the enantiomers or diastereomers, in any desired mixing ratio, or in each case in the form of a physiologically acceptable salt, or in each case in the form of a solvate, characterized in that in a first step a) a l-amino-3-aryl-butan-3-ol compound of the general formula II wherein R1, R2, R3, R4, R7, R8, R9, R!0, R11, R12 and R13 have the abovementioned meaning, in each case optionally in the form of one of its pure stereoisomers, in particular enantiomers or diastereomers, its racemates or in the form of a mixture of stereoisomers, in particular the enantiomers or diastereomers, in any desired mixing ratio, or in each case in the form of a physiologically acceptable salt, or in each case in the form of a solvate, is employed and elimination is carried out under the action of a formic acid, hydrochloric acid or hydrobromic acid to give a substituted 3-aryl-but-3-enyl-amine compound of the general formula III wherein R1, R2, R3, R4, R7, R8, R9, R10, R11, R12 and R13 have the abovementioned meaning, in each case optionally in the form of one of its pure stereoisomers, in particular enantiomers or diastereomers, its racemates or in the form of a mixture of stereoisomers, in particular the enantiomers or diastereomers, in any desired mixing ratio, or in each case in the form of a physiologically acceptable salt, or in each case in the form of a solvate, and in a second step b) the substituted 3-aryl-but-3-enyl- amine compound according to the general formula III formed is then hydrogenated under the participation of a metal catalyst and hydrogen to give a substituted 3-aryl-butyl-amine compound of the general formula I. 2. Process as claimed in claim 1, wherein for compounds according to formula I, formula II and formula III R4 is chosen from H or CH3, preferably R4 denotes H. 3. Process as claimed in claim 1, wherein for compounds according to formula I, formula II and formula III R1 is chosen from C1-3-alkyl, saturated or unsaturated, substituted or unsubstituted, branched or unbranched. 4. Process as claimed in claim 1, wherein for compounds according to formula I, formula II and formula III R4 is chosen from H or CH3, preferably R4 denotes H, and/or R1 is chosen from C1-3-alkyl, saturated or unsaturated, substituted or unsubstituted, branched or unbranched. 5. Process as claimed in one of claims 1 to 4, wherein for compounds according to formula I, formula II and formula III R7 and R8 in each case independently of one another are chosen from H or CH3, preferably R7 and R8 denote H or R7 and R8 denote CH3 or R7 denotes H and R8 denotes CH3, in particular R7 and R8 denote CH3. 6. Process as claimed in one of claims 1 to 5, wherein for compounds according to formula I, formula II and formula III R1 is chosen from C1-3-alkyl, saturated and unsubstituted, branched or unbranched, preferably from CH3, C2H5, I-propyl or n-propyl, in particular from CH3 or C2H5. 7. Process as claimed in one of claims 1 to 6, wherein for compounds according to formula I, formula II and formula III R and R independently of one another are chosen from H, C1-4- alkyl, saturated and unsubstituted, branched or unbranched; preferably from H, CH3, C2H5, I-propyl or t-butyl, in particular from H or CH3 or C2H5. 8. Process as claimed in claim 7, wherein for compounds according to formula I, formula II and formula III R3 = HandR2?H, preferably R3 = H and R2 = CH3 or C2H5, in particular R3 = H and R2 = CH3. 9. 9. Process as claimed in one of claims 1 to 6, wherein for compounds according to formula I, formula II and formula III R and R together form a C5-6-cycloalkyl radical, saturated or unsaturated, unsubstituted or mono- or polysubstituted, preferably saturated and unsubstituted, in particular cyclohexyl. 10. Process as claimed in one of claims 1 to 9, wherein for compounds according to formula I, formula II and formula III R9 and R13, where 3 or 4 of the radicals R9 to R13 must correspond to H, independently of one another are chosen from H, Cl, F, OH, CF2H, CF3 or C1-4-alkyl, saturated and unsubstituted, branched or unbranched; OR14 or SR14, where R4 is chosen from C1-3-alkyl, saturated and unsubstituted, branched or unbranched; preferably from H, Cl, F, OH, CF2H, CF3, OCH3 or SCH3 or R12 and R11 form a 3,4-OCH=CH ring in particular if R9, R11 and R13 correspond to H, one of R10 or R12 also corresponds to H, while the other is chosen from: Cl, F, OH, CF2H, CF3, OR14 or SR14, preferably from OH, CF2H, OCH3 or SCH3 or if R9 and R13 correspond to H and R11 corresponds to OH, OCH3, Cl or F, preferably Cl, one of R10 or R12 also corresponds to H, while the other corresponds to OH, OCH3, Cl or F, preferably Cl, or if R9, R10, R12 and R13 correspond to H, R11 is chosen from CF3, CF2H, Cl or F, preferably from F, or if R10, R11 and R12 correspond to H, one of R9 or R13 also corresponds to H, while the other is chosen from OH, OC2H5 or OC3H7. 11. Process as claimed in claim 1, wherein for compounds according to formula I, formula II and formula III R1 is chosen from C1-3-alkyl, saturated and unsubstituted, branched or unbranched; preferably CH3, C2H5, or C3H7/ in particular CH3 or C2H5, and/or R2 and R3 independently of one another are chosen from H, C1-4-alkyl, saturated and unsubstituted, branched or unbranched; preferably from H, CH3, C2H5, i-propyl or t-butyl, in particular from H or CH3 or C2H5, preferably: R3 = H and R2 ? H, preferably R3 = H and R2 = CH3 or C2H5, in particular R3 = H and R2 = CH3, or R2 and R3 together form a C5-6-cycloalkyl radical, saturated or unsaturated, unsubstituted or mono- or polysubstituted, preferably saturated and unsubstituted, in particular cyclohexyl, and/or R4 is chosen from H, and/or R7 and R8 in each case independently of one another are chosen from H or CH3, preferably R7 and R8 denote H or R7 and R8 denote CH3 or R7 denotes H and R8 denotes CH3, in particular R7 and R8 denote CH3; and/or R9 to R13, where 3 or 4 of the radicals R9 to R13 must correspond to H, independently of one another are chosen from H, Cl, F, OH, CF2H, CF3 or C1-4-alkyl, saturated and unsubstituted, branched or unbranched; OR14 or SR14, where R14 is chosen from C1-3-alkyl, saturated and unsubstituted, branched or unbranched; preferably from H, Cl, F, OH, CF2H, CF3, OCH3 or SCH3 or R12 and R11 form a 3,4-OCH=CH ring in particular if R9, R11 and R13 correspond to H, one of R10 or R12 also corresponds to H, while the other is chosen from: Cl, F, OH, CF2H, CF3, OR14 or SR14, preferably from OH, CF2H, OCH3 or SCH3 or if R9 and R13 correspond to H and R11 corresponds to OH, OCH3/ Cl or F, preferably Cl, one of R10 or R12 also corresponds to H, while the other corresponds to OH, OCH3, Cl or F, preferably Cl, or if R9, R10, R12 and R13 correspond to H, R11 is chosen from CF3, CF2H, Cl or F, preferably from F, or if R10, R11 and R12 correspond to H, one of R9 or R13 also corresponds to H, while the other is chosen from OH, OC2H5 or OC3H7. 12. Process as claimed in one of claims 1 to 11, wherein for compounds according to formula I where R3 = H and R2 ? H these are in the configurations Ia or Ib 13. Process as claimed in one of claims 1 to 12, wherein for compounds according to formula II where R3 = H and R2 ? H these are in the configurations IIa or IIb or in the configurations IIc and IId 14. Process as claimed in one of claims 1 to 13, wherein for compounds according to formula III where R3 = H, R2 ? H, R4 = H and R1 ? H these are in the configurations IIIa or IIIb or for compounds according to formula III where R3 = H, R2 ? H, R4 = H and R1 ? H there are in the configurations IIIc or IIId 15. Process as claimed in claim 1, wherein for the compound/compounds according to formula I at least one of these, preferably as the free base or as the hydrochloride, is chosen from the following group: ¦ 3-(3-dimethylamino-1 -ethyl-2-methyl-propyl)-phenol, ¦ (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl- propyl)-phenol ¦ (-)-(1R,2R)-3-(3-dimethylamino-l-ethyl-2-methyl» propyl)-phenol, ¦ (1S,2S)-3-(3-dimethylamino-l-ethyl-2-methyl- propyl)-phenol ¦ (+)-(1S,2S)-3-(3-dimethylamino-l-ethyl-2-methyl- propyl)-phenol ¦ (±) - (1RS,2RS) -3- (3-dimethylcimino-l-ethyl-2- methyl-propyl)-phenol ¦ rac-(IRS,2RS)-3-(3-dimethylamino-1-ethyl-2- methyl-propyl)-phenol, ¦ [3-(3-methoxy-phenyl)-2-methyl-pentyl]- dimethylamine, ¦ (2R,3R)-[3-(3-methoxy-phenyl)-2-methyl-pentyl]- dimethylamine, ¦ (-)-(2R,3R)-[3-(3-methoxy-phenyl)-2-methyl- pentyl]-dimethylamine, ¦ (2S,3S)-[3-(3-methoxy-phenyl)-2-methyl-pentyl]- dimethylamine, (+)-(2S,3S)-[3-(3-methoxy-phenyl)-2-methyl- pentyl]-dimethylamine, ¦ (±)-(2RS,3RS)-[3-(3-methoxy-phenyl)-2-methyl- pentyl]-dimethylamine, ¦ rac(2RS,3RS)-[3-(3-methoxy-phenyl)-2-methyl- pentyl]-dimethylamine, ¦ 3{[3-(p-isopropyl-phenyl-carbamoyl)-oxy-phenyl] - 2-methyl-pentyl}-dimethylamine, ¦ (2R,3R)-{3[3-(p-isopropyl-phenyl-carbamoyl)-oxy- phenyl] -2-methyl-pentyl}-dimethylamine, ¦ (2S,3S)-{3[3-(p-isopropyl-phenyl-carbamoyl)-oxy- phenyl] -2-methyl-pentyl}-dimethylamine, ¦ (2SR,3SR)-{3[3-(p-isopropyl-phenyl-carbamoyl)- oxy-phenyl]-2-methyl-pentyl}-dimethylamine preferably ¦ 3-(3-dimethylamino-l-ethyl-2-methyl-propyl)- phenol, ¦ (1R,2R)-3-(3-dimethylamino-l-ethyl-2-methyl- propyl)-phenol, ¦ (-)-(1R,2R)-3-(3-dimethylamino-l-ethyl-2-methyl- propyl)-phenol, ¦ (1S,2S)-3-(3-dimethylamino-1-ethyl-2-methyl- propyl)-phenol, ¦ (+)-(1S,2S)-3-(3-dimethylamino-l-ethyl-2-methyl- propyl)-phenol, ¦ (±)-(1RS,2RS)-3-(3-dimethylamino-l-ethyl-2- methyl-propyl)-phenol, ¦ rac-(1RS,2RS)-3-(3-dimethylamino-l-ethyl-2- methyl-propyl)-phenol, ¦ [3-(3-methoxy-phenyl)-2-methyl-pentyl]- dimethylamine, ¦ (2R,3R)-[3-(3-methoxy-phenyl)-2-methyl-pentyl]- dimethylamine, ¦ (-)-(2R,3R)-[3-(3-methoxy-phenyl)-2-methyl- pentyl]-dimethylamine, ¦ (2S,3S)-[3-(3-methoxy-phenyl)-2-methyl-pentyl]- dimethylamine, ¦ (+)-(2S,3S)-[3-(3-methoxy-phenyl)-2-methyl- pentyl]-dimethylamine, I in particular [3-(3-methoxy-phenyl)-2-methyl-pentyl]- dimethylamine, ¦ (2R,3R)-[3-(3-methoxy-phenyl)-2-methyl-pentyl]- dimethylamine, ¦ (-)-(2R,3R)-[3-(3-methoxy-phenyl)-2-methyl- pentyl]-dimethylamine, ¦ (2S,3S)-[3-(3-methoxy-phenyl)-2-methyl-pentyl]- dimethylamine, ¦ (+)-(2S,3S)-[3-(3-methoxy-phenyl)-2-methyl- pentyl]-dimethylamine. 16. Process as claimed in claim 1, wherein for the compound/compounds according to formula II employed at least one of these, preferably as the free base or as the hydrochloride, is chosen from the following group: ¦ 3-(3-dimethylamino-l-ethyl~l-hydroxy-2-methyl- propyl)-phenol, ¦ (1S,2S)-3-(3-dimethylamino-l-ethyl-l-hydroxy-2- methyl-propyl)-phenol, ¦ (1R,2S)-3-(3-dimethylamino-l-ethyl-l-hydroxy-2- methyl-propyl)-phenol, ¦ (1RS,2SS)-3-(3-dimethylamino-l-ethyl-l-hydroxy-2~ methyl-propyl)-phenol, ¦ (1S,2R)-3-(3-dimethylamino-l-ethyl-l-hydroxy-2- methyl-propyl)-phenol, ¦ (1R,2R)-3-(3-dimethylamino-l-ethyl-l-hydroxy-2- methyl-propyl)-phenol, ¦ (1RS,2RR)-3-(3-dimethylamino-l-ethyl-l-hydroxy-2- methyl-propyl)-phenol, ¦ [3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol]- dimethylamine, ¦ (2S,3S)-[3-(3-methoxy-phenyl)-2-methyl-pentan-3- ol]-dimethylamine, ¦ (2S,3R)-[3-(3-methoxy-phenyl)-2-methyl-pentan-3- ol]-dimethylamine, ¦ (2SS,3RS)- [3-(3-methoxy-phenyl)-2-methyl-pentan- 3-ol]-dimethylamine, ¦ (2R,3S)-[3-(3-methoxy-phenyl)-2-methyl-pentan-3- ol]-dimethylamine, " (2R,3R)- [3-(3-methoxy-phenyl)-2-methyl-pentan-3- ol] -dimethylamine ¦ (2RR,3RS)-[3-(3-methoxy-phenyl)-2-methyl-pentan- 3-ol]-dimethylamine, ¦ {3[3-(p-isopropyl-phenyl-carbamoyl)-oxy-phenyl]- 2-methyl-pentan-3-ol}-dimethylamine, ¦ (2S,3R)-{3[3-(p-isopropyl-phenyl-carbamoyl)-oxy- phenyl] -2-methyl-pentan-3-ol}-dimethylamine, ¦ (2S,3S)-{3[3-(p-isopropyl-phenyl-carbamoyl)-oxy- phenyl] -2-methyl-pentan-3-ol}-dimethylamine " (2SS,3RS)-{3[3-(p-isopropyl-phenyl-carbamoyl)- oxy-phenyl]-2-methyl-pentan-3-ol}-dimethylamine, ¦ (2R,3S)-{3[3-(p-isopropyl-phenyl-carbamoyl)-oxy- phenyl] -2-methyl-pentan-3-ol}-dimethylamine, ¦ (2R,3R)-{3 [3-(p-isopropyl-phenyl-carbamoyl)-oxy- phenyl] -2-methyl-pentan-3-ol}-dimethylamine, ¦ (2RR,3RS)-{3[3-(p-isopropyl-phenyl-carbamoyl)- oxy-phenyl]-2-methyl-pentan-3-ol}-dimethylamine, preferably ¦ 3-(3-dimethylamino-l-ethyl-l-hydroxy-2-methyl- propyl)-phenol, ¦ (1S,2S)-3-(3-dimethylamino-r-ethyl-l-hydroxy-2- methyl-propyl)-phenol, ¦ (1R,2S)-3-(3-dimethylamino-l-ethyl-l-hydroxy-2- methyl-propyl)-phenol, ¦ (1RS,2SS)-3-(3-dimethylamino-l-ethyl-l-hydroxy-2- methyl-propyl)-phenol, ¦ (1S,2R)-3-(3-dimethylamino-l-ethyl-l-hydroxy-2- methyl-propyl)-phenol, ¦ (1R,2R)-3-(3-dimethylamino-l-ethyl-l-hydroxy-2- tnethyl-propyl) -phenol, ¦ (lRS,2RR)-3-(3-dimethylamino-l-ethyl-l-hydroxy-2- methyl-propyl)-phenol, [3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol]- dimethylamine, ¦ (2S,3S)-[3-(3-methoxy-phenyl)-2-methyl-pentan-3- ol]-dimethylamine, ¦ (2S,3R)-[3-(3-methoxy-phenyl)-2-methyl-pentan-3- ol]-dimethylamine, ¦ (2SS,3RS)-[3-(3-methoxy-phenyl)-2-methyl-pentan- 3-ol]-dimethylamine, ¦ (2R,3S)-[3-(3-methoxy-phenyl)-2-methyl-pentan-3- ol]-dimethylamine, ¦ (2R,3R)-[3-(3-methoxy-phenyl)-2-methyl-pentan-3- ol]-dimethylamine, ¦ (2RR,3RS)-[3-(3-methoxy-phenyl)-2-methyl-pentan- 3-ol]-dimethylamine, in particular ¦ [3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol]- dimethylamine, ¦ (2S,3S)-[3-(3-methoxy-phenyl)-2-methyl-pentan-3- ol]-dimethylamine, ¦ (2S,3R)-[3-(3-methoxy-phenyl)-2-methyl-pentan-3- ol]-dimethylamine, ¦ (2SS,3RS)-[3-(3-methoxy-phenyl)-2-methyl-pentan- 3-ol] -dimethylamine, ¦ (2R,3S)-[3-(3-methoxy-phenyl)-2-methyl-pentan-3- ol]-dimethylamine, ¦ (2R,3R)-[3-(3-methoxy-phenyl)-2-methyl-pentan-3- ol]-dimethylamine, ¦ (2RR,3RS)-[3-(3-methoxy-phenyl)-2-methyl-pentan- 3-ol]-dimethylamine, preferably ¦ (2S,3S)-[3-(3-methoxy-phenyl)-2-methyl-pentan-3- ol]-dimethylamine, ¦ (2S,3R)-[3-(3-methoxy-phenyl)-2-methyl-pentan-3- ol]-dimethylamine, or ¦ (2R,3R)-[3-(3-methoxy-phenyl)-2-methyl-pentan-3- ol]-dimethylamine or • (2R,3S)-[3-(3-methoxy-phenyl)-2-methyl-pentan-3- ol]-dimethylamine. 17. Process as claimed in claim 1, wherein for the compound/compounds according to formula III at least one of these, preferably as the free base or as the hydrochloride, is chosen from the following group: ¦ 3-(3-dimethylamino-1-ethenyl-2-methyl-propyl)- phenol, ¦ (Z)-(2R)-3-(3-dimethylamino-1-ethenyl-2-methyl- propyl)-phenol, ¦ (E)-(2R)-3-(3-dimethylamino-1-ethenyl-2-methyl- propyl)-phenol, ¦ (Z,E)-(2R)-3-(3-dimethylamino-1-ethenyl-2-methyl- propyl)-phenol, ¦ (Z) - (2S) -3- (3-dimethylamino-1-ethenyl-2-methyl- propyl)-phenol, ¦ (E)- (2S)-(3-dimethylamino-1-ethenyl-2-methyl- propyl)-phenol, ¦ (Z,E)- (2S)-3-(3-dimethylamino-1-ethenyl-2-methyl- propyl)-phenol, ¦ 3-(3-dimethylamino-1-ethenyl-2-methyl-propyl)- phenol, ¦ (Z)-(2R)-3-(3-dimethylamino-1-ethenyl-l-2-methyl- propyl)-phenol, ¦ (E)-(2R)-3-(3-dimethylamino-1-ethenyl-l-2-methyl- propyl)-phenol, ¦ (Z,E)-(2R)-3-(3-dimethylamino-1-ethenyl-l-2- methyl-propyl)-phenol, ¦ (Z)-(2S)-3-(3-dimethylamino-1-ethenyl-l-2-methyl- propyl)-phenol, ¦ (E)-(2S)-(3-dimethylamino-1-ethenyl-l-2-methyl- propyl)-phenol, ¦ (Z,E)-(2S)-3-(3-dimethylamino-1-ethenyl-2-methyl- propyl)-phenol, ¦ [3-(3-methoxy-phenyl)-2-methyl-pent-3-enyl]- dimethylamine, ¦ (Z)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (E)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (Z,E)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (Z)-(2S)- [3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (E)-(2S)- [3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (Z,E)-(2S)-[3-(3-methoxy-pnenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ {3[3-(p-isopropyl-phenyl-carbamoyl)-oxy-phenyl]- 2-methyl-pent-3-enyl}-dimethylamine, ¦ (Z)-(2R)-{3[3-(p-isopropyl-phenyl-carbamoyl)-oxy- phenyl] -2-methyl-pent-3-enyl}-dimethylamine, ¦ (E)-(2R)-{3[3-(p-isopropyl-phenyl-carbamoyl)-oxy- phenyl] -2-methyl-pent-3-enyl}-dimethylamine, ¦ (Z,E)-(2R)-{3[3-(p-isopropyl-phenyl-carbamoyl)- oxy-phenyl]-2-methyl-pent-3-enyl}-dimethylamine, ¦ (Z)-(2S)-{3[3-(p-isopropyl-phenyl-carbamoyl)-oxy- phenyl] -2-methyl-pent-3-enyl}-dimethylamine, ¦ (E)-(2S)-{3[3-(p-isopropyl-phenyl-carbamoyl)-oxy- phenyl] -2-methyl-pent-3-enyl}-dimethylamine, ¦ (Z,E)-(2S)-{3[3-(p-isopropyl-phenyl-carbamoyl)- oxy-phenyl]-2-methyl-pent-3 -enyl}-dimethylamine, preferably ¦ 3-(3-dimethylamino-1-ethenyl-2-methyl-propyl)- phenol, ¦ (Z)-(2R)-3-(3-dimethylamino-1-ethenyl-2-methyl- propyl)-phenol, " (E)-(2R)-3-(3-dimethylamino-1-ethenyl-2-methyl- propyl)-phenol, ¦ (Z,E)-(2R)-3-(3-dimethylamino-1-ethenyl-2-methyl- propyl)-phenol, " (Z) - (2S) -3- (3-dimethylamino-1-ethenyl-2-methyl- propyl)-phenol, ¦ (E)-(2S)-(3-dimethylamino-1-ethenyl-2-methyl- propyl)-phenol, ¦ (Z,E)-(2S)-3-(3-dimethylamino-1-ethenyl-2-methyl- propyl)-phenol, ¦ [3-(3-methoxy-phenyl)-2-methyl-pent-3-enyl]- dimethylamine, ¦ (Z)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (E)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (Z,E)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (Z)- (2S)- [3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (E)- (2S)- [3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (Z,E)-(2S)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, in particular ¦ [3-(3-methoxy-phenyl)-2-methyl-pent-3-enyl]- dimethylamine, ¦ (Z)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (E)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (Z,E)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (Z)-(2S)- [3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (E)-(2S)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (Z,E)-(2S)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, preferably ¦ (Z) - (2R) - [3- (3-methoxy-phenyl)-2-methyl-pent-3-enyl]- dimethylamine, ¦ (E) - (2R) - [3- (3-methoxy-phenyl)-2-methyl-pent-3-enyl]- dimethylamine or ¦ (Z,E) - (2R) - [3- (3-methoxy-pehnyl) -2-methyl-pent-3-enyl]- dimethylamine, or ¦ (Z) - (2S) - [3-(3-methoxy-phenyl)-2-methyl-pent-3-enyl]- dimethylamine, • (E) - (2S) - [3- (3-methoxy-pehnyl)-2-methyl-pent-3-enyl}- dimethylamine or ¦ (Z, E) -(2S) - [3- (3-methoxy-phentyl) -2-methyl-pent-3-enyl]- dimethylamine. 18. Process as claimed in claim 1, wherein a chiral center is present in the compound according to formula II employed, at position 2 according to formula II. 19. Process as claimed in claim 1, wherein a chiral center is present in the compound according to formula I, at position 2 according to formula I. 20. Process as claimed in claim 1, wherein a chiral center is present in the compound according to formula III, at position 2 according to formula III. 21. Process as claimed in claim 1, wherein the compound according to formula II employed is enantiomerically pure. 22. Process as claimed in claim 1, wherein the compound according to formula II employed is diastereomerically pure. 23. Process as claimed in claim 1, wherein the compound according to formula II employed is enantiomerically and diastereomerically pure. 24. Process as claimed in claim 1, wherein the compound according to formula II employed is chosen from: • (2S), 3S) - [3-(3-methoxy-phenyl) -2-methyl-pentan-3-ol]- dimethylamine, • (2S, 3R) - [3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol]- dimethylamine or is a mixture of (2S, 3S) - [3-(3-methoxy-phenyl)-2-methyl-pentan- 3-ol]-dimethylamine and (2S, 3R) -[3-(3-methoxy-phenyl)-2- methyl-pentan-3-ol]-dimethylamine, or (2SS, 3RS) - [3-(3- methoxy-phenyl)-2-methyl-pentan-3-ol]-dimethylamine. 25. Process as claimed in claim 1, wherein the compound according to formula II employed is chosen from: • (2R), 3R) - [3-(3-methoxy-phenyl) -2-methyl-pentan-3-ol]- dimethylamine, • (2R, 3S) - [3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol]- dimethylamine or is a mixture of (2R, 3R) - [3-(3-methoxy-phenyl)-2-methyl- pentan-3-ol]-dimethylamine and (2R, 3S) -[3-(3-methoxy-phenyl)- 2-methyl-pentan-3-ol]-dimethylamine, or (2RR, 3RS) - [3-(3- methoxy-phenyl)-2-methyl-pentan-3-ol]-dimethylamine. 26. Process as claimed in claim 1, wherein the compound according to formula II employed is chosen from: • (2S), 3S) - [3-(3-methoxy-phenyl) -2-methyl-pentan-3-ol, • (2S, 3R) - [3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol or is a mixture of (2S, 3S) -l-dimethylamino-3-(3-methoxy-phenyl)- 2-methyl-pentan-3-ol and (2S, 3R.) -l-dimethylamino-3-(3- methoxy-phenyl)-2-methyl-pentan-3-ol, or (2SS, 3RS)-[3-(3- methoxy-phenyl)-2-methyl-pentan-3-ol]-dimethylamine. 27. Process as claimed in claim 1, wherein the compound according to formula II employed is chosen from: • (2R), 3R) -l-dimethylamino-3-(3-methoxy-phenyl)-2-methyl- pentan-3-ol, • (2R, 3S) -l-dimethylamino-3-(3-methoxy-phenyl)-2-methyl- pentan-3-ol or is a mixture of (2R, 3R) -1-dimethylamino-3-(3-methoxy-phenyl)- 2-methyl-pentan-3-ol and (2R, 3S) -1-dimethylamino-3-(3- methoxy-phenyl)-2-methyl-pentan-3-ol, or (2RR, 3RS) - [3-(3- methoxy-phenyl)-2-methyl-pentan-3-ol]-dimethylamine. 28. Process as claimed in one of claims 1 to 17, wherein organic acids or halogen halide acids are used in step a). 29. Process as claimed in claim 18, wherein formic acid, hydrochloric acid or hydrobromic acid are used is step a). 30. Process as claimed in claim 18, wherein formic acid is used in step a). 31. Process as claimed in claim 18, wherein hydrochloric acid is used in step a). 32. Process as claimed in claim 18, wherein hydrobromic acid is used in step a). 33. Process as claimed in claim 18, wherein the acid in step a) is employed in a high concentration. 34. Process as claimed in claim 21, wherein the hydrochloric acid in step a) is > 20%, preferably > 30%, in particular > 35%. 35. Process as claimed in one of claims 1 to 24, wherein after step a), the compounds according to formula III which have undergone elimination are crystallized with hydrochloric acid gas. 36. Process as claimed in one of claims 1 to 25, wherein the reaction time of step a) is between 2 and 10 h, preferably between 3 and 8 h, in particular between 4 and 6 h. 37. Process as claimed in one of claims 1 to 26, wherein the reaction temperature in step a) is between 35 and 100°C, preferably 45 and 80°C, in particular between 50 and 60°C. 38. Process as claimed in one of claims 1 to 27, wherein the solvent in step a) is chosen from: H2O or alcohol or aqueous alcohol solutions. 39. Process as claimed in one of claims 18 to 24, wherein the solvent in step a) is aqueous acid. 40. Process as claimed in one of claims 18 to 24, wherein in step a), the compound according to formula II employed is dissolved in aqueous acid. 41. Process as claimed in one of claims 21 or 24, wherein in step a), the compound according to formula II employed is dissolved in aqueous hydrocholoric acid. 42. Process as claimed in claim 1, wherein in step b), the solvent is chosen from: H2O or alcohol or aqueous alcoholic or aqueous acidic solutions, preferably from aqueous acidic solutions. 43. Process as claimed in claim 1, wherein in step b), the solvent is chosen from: H2O or ethanol or aqueous ethanolic solution or aqueous hydrochloric acid, preferably from aqueous hydrochloric acid. 44. Process as claimed in claim 1, wherein in step b), the catalyst used comprises a noble metal, preferably platinum, gold or palladium, in particular palladium. 45. Process as claimed in claim 44, wherein in step b), the catalyst used is palladium-on-active charcoal or palladium (II) chloride. 46. Process as claimed in claim 44, wherein in step b), the catalyst used is palladium-on-active charcoal (1-10 wt.%, preferably 5 wt.%). 47. Process as claimed in claim 1, wherein the temperature in step b) is kept between 20 and 40°C, preferably between 20 and 35, in particular 25°C. 48. Process as claimed in claim 1, wherein in step b), an inert gas atmosphere, in particular a nitrogen inert gas, is applied before the hydrogenation. 49. Process as claimed in claim 1, wherein in step b), the hydrogenation step takes place under a hydrogen pre-pressure of 3- 10 bar, preferably 4-7 bar, in particular 5 bar and/or the hydrogenation step takes place under a hydrogen internal pressure of 0.5-3 bar, preferably 0.75-2 bar, in particular 1 bar. 50. Process as claimed in claim 1, wherein in step b), the starting substances are highly dilute/diluted in the solvent at the start. 51. Process as claimed in claim 1, wherein the solvent for both steps a) and b) is an aqueous acidic solution, preferably aqueous hydrochloric acid. 52. Process as claimed in claims 1 and 51, wherein no product is isolated between step a) and step b). 53. Process as claimed in claim 52, wherein the starting substances are highly dilute/diluted in the solvent at the start. 54. Process as claimed in one of claims 1 or 52, wherein the compound according to formula II employed is dissolved in aqueous acid. 55. Process as claimed in claim 54, wherein the compound according to formula II employed is dissolved in aqueous hydrochloric acid. 56. Process for the preparation of a substituted 3-aryl-butyl-amine compound of the general formula I wherein R1 is chosen from H, C1-3-alkyl, branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted, R and R in each case independently of one another are chosen from H or C1-4-alkyl, branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted, R4 is chosen from H, C1-3-alkyl, branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted, R and R in each case independently of one another are chosen from H or C1-3-alkyl, branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted, R9 to R13, where 3 or 4 of the radicals R9 to R13 must correspond to H, independently of one another are chosen from H, Cl, F, OH, CF2H, CF3 or C1-4-alkyl, saturated and unsubstituted, branched or unbranched; OR14 or SR14, R14 is chosen from C1-3-alkyl, saturated and unsubstituted, branched or unbranched. where R17 and R18 in each case independently of one another are chosen from H; C1-6-alkyl, branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted; phenyl, benzyl or phenethyl, in each case unsubstituted or mono- or polysubstituted, or R9 and R10 or R10 and R11 together form an OCH2O, OCH2CH2O, OCH=CHO, CH=C(CH3)O, OC(CH3)==CH, (CH2)4 or OCH=CHO ring, in each case in the form of one of its pure stereoisomers, in particular enantiomers or diastereomers, its racemates or in the form of a mixture of stereoisomers, in particular the enantiomers or diastereomers, in any desired mixing ratio, or in each case in the form of a physiologically acceptable salt, or in each case in the form of a solvate, characterized in that a substituted 3-aryl-but-3-enyl-amine compound of the general formula III wherein R1, R2, R3, R4, R7, R8, R9, R10, Rn, R12 and R13 have the abovementioned meaning, in each case optionally in the form of one of its pure stereoisomers, in particular enantiomers or diastereomers, its racemates or in the form of a mixture of stereoisomers, in particular the enantiomers or diastereomers, in any desired mixing ratio, or in each case in the form of a physiologically acceptable salt, or in each case in the form of a solvate, is hydrogenated with the participation of a metal catalyst and hydrogen to give a substituted 3-aryl-butyl-amine compound of the general formula I. 57. Process as claimed in claim 56, wherein for compounds according to formula I and formula III R4 is chosen from H or CH3, preferably R4 denotes H. 58. Process as claimed in claim 56, wherein for compounds according to formula I and formula III R1 is chosen from C1-3-alkyl, saturated or unsaturated, substituted or unsubstituted, branched or unbranched. 59. Process as claimed in claim 56, wherein for compounds according to formula I and formula III, R4 is chosen from H or CH3, preferably R4 denotes H, and/or R1 is chosen from C1-3-alkyl, saturated or unsaturated, substituted or unsubstituted, branched or unbranched. 60. Process as claimed in one of claims 56 to 60, wherein for compounds according to formula I and formula III R and R in each case independently of one another are chosen from H or CH3, preferably R7 and R8 denote H or R7 and R8 denote CH3 or R7 denotes H and R8 denotes CH3, in particular R7 and R8 denote CH3. 61. Process as claimed in one of claims 56 to 60, wherein for compounds according to formula I and formula III R1 is chosen from C1-3-alkyl, saturated and unsubstituted, branched or unbranched, preferably from CH3, C2H5, i-propyl or n-propyl, in particular from CH3 or C2H5. 62. Process as claimed in one of claims 56 to 61, wherein for compounds according to formula I and formula III R2 and R3 independently of one another are chosen from H, C1-4-alkyl, saturated and unsubstituted, branched or unbranched; preferably from H, CH3, C2H5, i-propyl or t-butyl, in particular from H or CH3 or C2H5. 63. Process as claimed in claim 62, wherein for compounds according to formula I and formula III R3 = HandR2 ? H, preferably R3 = H and R2 = CH3 or C2H5, in particular R3 = H and R2 = CH3. 64. Process as claimed in one of claims 56 to 61, wherein for compounds according to formula I and formula III R and R together form a C5-6-cycloalkyl radical, saturated or unsaturated, unsubstituted or mono- or polysubstituted, preferably saturated and unsubstituted, in particular cyclohexyl. 65. Process as claimed in one of claim 56 to 64, wherein for compounds according to formula I and formula III R9 and R13, where 3 or 4 of the radicals R9 to R13 must correspond to H, independently of one another are chosen from H, Cl, F, OH, CF2H, CF3 or d.4-alkyl, saturated and unsubstituted, branched or unbranched; OR14 or SR14, R14 is chosen from C1-3-alkyl, saturated and unsubstituted, branched or unbranched; preferably from H, Cl, F, OH, CF2H, CF3, OCH3 or SCH3 or R12 and R11 form a 3,4-OCH=CH ring in particular if R9, R11 and R13 correspond to H, one of R10 or R12 also corresponds to H, while the other is chosen from: Cl, F, OH, CF2H, CF3, OR14 or SR14, preferably from OH, CF2H, OCH3 or SCH3 or if R9 and R13 correspond to H and R11 corresponds to OH, OCH3, Cl or F, preferably Cl, one of R10 or R12 also corresponds to H, while the other corresponds to OH, OCH3/ Cl or F, preferably Cl, or if R9, R10, R12 and R13 correspond to H, R11 is chosen from CF3, CF2H, Cl or F, preferably from F, or if R10, R11 and R12 correspond to H, one of R9 or R13 also corresponds to H, while the other is chosen from OH, OC2H5 or OC3H7. 66. Process as claimed in claim 56, wherein for compounds according to formula I and formula III R1 is chosen from C1-3-alkyl, saturated and unsubstituted, branched or unbranched; preferably CH3, C2H5, or C3H7, in particular CH3 or C2H5, and/or R2 and R3 independently of one another are chosen from H, C1-4-alkyl, saturated and unsubstituted, branched or unbranched; preferably from H, CH3, C2H5, i-propyl or t-butyl, in particular from H or CH3 or C2H5, preferably: R3 = H and R2 ? H, preferably R3 = H and R2 = CH3 or C2H5, in particular R3 = H and R2 = CH3, or R2 and R3 together form a C5-6-cycloalkyl radical, saturated or unsaturated, unsubstituted or mono- or polysubstituted, preferably saturated and unsubstituted, in particular cyclohexyl, and/or R4 is chosen from H, and/or R7 and R8 in each case independently of one another are chosen from H or CH3, preferably R7 and R8 denote H or R7 and R8 denote CH3 or R7 denotes H and R8 denotes CH3, in particular R7 and R8 denote CH3; and/or R9 to R13, where 3 or 4 of the radicals R9 to R13 must correspond to H, independently of one another are chosen from H, Cl, F, OH, CF2H, CF3 or C1-4-alkyl, saturated and unsubstituted, branched or unbranched; OR14 or SR14, where R14 is chosen from C1-3-alkyl, saturated and unsubstituted, branched or unbranched; preferably from H, Cl, F, OH, CF2H, CF3, OCH3 or SCH3 or R12 and R11 form a 3,4-OCH=CH ring in particular if R9, R11 and R13 correspond to H, one of R10 or R12 also corresponds to H, while the other is chosen from: Cl, F, OH, CF2H, CF3, OR14 or SR14, preferably from OH, CF2H, OCH3 or SCH3 or if R9 and R13 correspond to H and R11 corresponds to OH, OCH3, Cl or F, preferably Cl, one of R10 or R12 also corresponds to H, while the other corresponds to OH, OCH3, Cl or F, preferably Cl, or if R9, R10, R12 and R13 correspond to H, R11 is chosen from CF3, CF2H, Cl or F, preferably from F, or if R10, R11 and R12 correspond to H, one of R9 or R13 also corresponds to H, while the other is chosen from OH, OC2H5 or OC3H7. 67. Process as claimed in one of claims 56 to 66, wherein that for compounds according to formula I where R3 = H and R2 ? H these are in the configurations Ia or Ib 68. Process as claimed in one of claims 56 to 67, wherein for comgounds according to formula III where R3 = H, R2 ? H, R4 = H and R1 ? H these are in the configurations IIIa or IIIb or for compounds according to formula III where R3 = H, R2 ? H, R4 = H and R1 ? H these are in the configurations IIIc or IIId 69. Process as claimed in claim 56, wherein for the compound/compounds according to formula I at least one of these, preferably as the free base or as the hydrochloride, is chosen from the following group: ¦ 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)- phenol, ¦ (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl- propyl)-phenol ¦ (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl- propyl)-phenol, ¦ (1S,2S)-3-(3-dimethylamino-1-ethyl-2-methyl- propyl)-phenol ¦ (+)-(IS,2S)-3-(3-dimethylamino-1-ethyl-2-methyl- propyl)-phenol ¦ (±)-(1RS,2RS)-3-(3-dimethylamino-1-ethyl-2- methyl-propyl)-phenol ¦ rac-(1RS,2RS)-3-(3-dimethylamino-1-ethyl-2- methyl-propyl)-phenol, ¦ [3-(3-methoxy-phenyl)-2-methyl-pentyl]- dimethylamine, ¦ (2R,3R)-[3-(3-methoxy-phenyl)-2-methyl-pentyl]- dimethylamine, ¦ (-)-(2R,3R)-[3-(3-methoxy-phenyl)-2-methyl- pentyl]-dimethylamine, ¦ (2S,3S)-[3-(3-methoxy-phenyl)-2-methyl-pentyl]- dimethylamine, ¦ (+)-(2S,3S)-[3-(3-methoxy-phenyl)-2-methyl- pentyl]-dimethylamine, ¦ (±)-(2RS,3RS)-[3-(3-methoxy-phenyl)-2-methyl- pentyl]-dimethylamine, ¦ rac(2RS,3RS)-[3-(3-methoxy-phenyl)-2-methyl- pentyl]-dimethylamine, ¦ 3{ [3- (p-isopropyl-phenyl-cairbamoyl) -oxy-phenyl] - 2-methyl-pentyl}-dimethylamine, ¦ (2R,3R)-{3[3-(p-isopropyl-phenyl-carbamoyl)-oxy- phenyl] -2-methyl-pentyl}-dimethylamine, ¦ (2S,3S)-{3[3-(p-isopropyl-phenyl-carbamoyl)-oxy- phenyl] -2-methyl-pentyl}-dimethylamine, ¦ (2SR,3SR)-{3[3-(p-isopropyl-phenyl-carbamoyl)- oxy-phenyl]-2-methyl-pentyl}-dimethylamine preferably ¦ 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)- phenol, ¦ (1R,2R)-3-(3-dimethylaminO"l-ethyl-2-methyl- propyl)-phenol, ¦ (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl- propyl)-phenol, ¦ (IS,2S)-3-(3-dimethylamino-1-ethyl-2-methyl- propyl)-phenol, ¦ (+)-(IS,2S)-3-(3-dimethylamino-1-ethyl-2-methyl- propyl)-phenol, ¦ (±)-(1RS,2RS)-3-(3-dimethylamino-1-ethyl-2- methyl-propyl)-phenol, ¦ rac-(1RS,2RS)-3-(3-dimethylamino-1-ethyl-2- methyl-propyl)-phenol, ¦ [3-(3-methoxy-phenyl)-2-methyl-pentyl]- dimethylamine, ¦ (2R,3R)-[3-(3-methoxy-phenyl)-2-methyl-pentyl]- dimethylamine, ¦ (-)-(2R,3R)-[3-(3-methoxy-phenyl)-2-methyl- pentyl]-dimethylamine, ¦ (2S,3S)- [3-(3-methoxy-phenyl)-2-methyl-pentyl] - dimethylamine, ¦ (+)-(2S,3S)-[3-(3-methoxy-phenyl)-2-methyl- pentyl]-dimethylamine, in particular ¦ [3-(3-methoxy-phenyl)-2-methyl-pentyl]- dimethylamine, ¦ (2R,3R)-[3-(3-methoxy-phenyl)-2-methyl-pentyl]- dimethylamine, ¦ (-)-(2R,3R)-[3-(3-methoxy-phenyl)-2-methyl- pentyl]-dimethylamine, ¦ (2S,3S)-[3-(3-methoxy-phenyl)-2-methyl-pentyl]- dimethylamine, ¦ ( + )-(2S,3S)- [3-(3-methoxy-phenyl)-2-methyl- pentyl]-dimethylamine. 70. Process as claimed in claim 56, wherein for the compound/compounds according to formula III employed at least one of these, preferably as the free base or as the hydrochloride, is chosen from the following group: ¦ 3-(3-dimethylamino-1-ethenyl-2-methyl-propyl)- phenol, ¦ (Z)-(2R)-3-(3-dimethylamino-1-ethenyl-2-methyl- propyl)-phenol, ¦ (E)-(2R)-3-(3-dimethylamino-1-ethenyl-2-methyl- propyl)-phenol, ¦ (Z,E)-(2R)-3-(3-dimethylamino-1-ethenyl-2-methyl- propyl)-phenol, ¦ (Z)-(2S)-3-(3-dimethylamino-1-ethenyl-2-methyl- propyl)-phenol, ¦ (E)-(2S)-(3-dimethylamino-1-ethenyl-2-methyl- propyl)-phenol, ¦ (Z,E)-(2S)-3-(3-dimethylamino-1-ethenyl-2-methyl- propyl)-phenol, ¦ 3-(3-dimethylamino-1-ethenyl-2-methyl-propyl)- phenol, ¦ (Z)-(2R)-3-(3-dimethylamino-1-ethenyl-l-2-methyl- propyl)-phenol ¦ (E)-(2R)-3-(3-dimethylamino-1-ethenyl-l-2-methyl- propyl)-phenol ¦ (Z,E)-(2R)-3-(3-dimethylamino-1-ethenyl-1-2- methyl-propyl)-phenol ¦ (Z)-(2S)-3-(3-dimethylamino-1-ethenyl-1-2-methyl- propyl)-phenol ¦ (E)-(2S)-(3-dimethylamino-1-ethenyl-l-2-methyl- propyl)-phenol ¦ (Z,E)-(2S)-3-(3-dimethylamino-1-ethenyl-2-methyl- propyl)-phenol ¦ [3-(3-methoxy-phenyl)-2-methyl-pent-3-enyl]- dimethylamine, ¦ (Z)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (E)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (Z,E)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (Z)-(2S)- [3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (E)-(2S)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (Z,E)- (2S)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ {3[3-(p-isopropyl-phenyl-carbamoyl)-oxy-phenyl] - 2-methyl-pent-3-enyl}-dimethylamine, ¦ (Z)-(2R)-{3[3-(p-isopropyl-phenyl-carbamoyl)-oxy- phenyl] -2-methyl-pent-3-enyl}-dimethylamine, ¦ (E)-(2R)-{3[3-(p-isopropyl-phenyl-carbamoyl)-oxy- phenyl] -2-methyl-pent-3-enyl}-dimethylamine, ¦ (Z,E)-(2R)-{3[3-(p-isopropyl-phenyl-carbamoyl)- oxy-phenyl]-2-methyl-pent-3-enyl}-dimethylamine, ¦ (Z)-(2S)-{3[3-(p-isopropyl-phenyl-carbamoyl)-oxy- phenyl ]-2-methyl-pent-3 -enyl}-dimethylamine, ¦ (E)-(2S)-{3 [3-(p-isopropyl-phenyl-carbamoyl)-oxy- phenyl] -2-methyl-pent-3-enyl}-dimethylamine, ¦ (Z,E)-(2S)-{3[3-(p-isopropyl-phenyl-carbamoyl)- oxy-phenyl]-2-methyl-pent-3-enyl}-dimethylamine, preferably ¦ 3-(3-dimethylamino-1-ethenyl-2-methyl-propyl)- phenol, ¦ (Z)-(2R)-3-(3-dimethylamino-1-ethenyl-2-methyl- propyl)-phenol, ¦ (E)-(2R)-3-(3-dimethylamino-1-ethenyl-2-methyl- propyl)-phenol, ¦ (Z,E) - (2R) -3- (3-dimethylamino-1-ethenyl-2-methyl- propyl)-phenol, ¦ (Z)- (2S)-3- (3-dimethylamino-1-ethenyl-2-methyl- propyl)-phenol, ¦ (E)-(2S)-(3-dimethylamino-1-ethenyl-2-methyl- propyl)-phenol, ¦ (Z,E)-(2S)-3-(3-dimethylamino-1-ethenyl-2-methyl- propyl)-phenol, ¦ [3-(3-methoxy-phenyl)-2-methyl-pent-3-enyl]- dimethylamine, ¦ (Z)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (E)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (Z,E)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (Z)-(2S)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (E)-(2S)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (Z,E)-(2S)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, in particular ¦ [3-(3-methoxy-phenyl)-2-methyl-pent-3-enyl]- dimethylamine, ¦ (Z)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (E)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (Z,E)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (Z)-(2S)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (E)- (2S)- [3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (Z,E)-(2S)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, preferably ¦ (Z)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (E)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine or ¦ (Z,E)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, or ¦ (Z)-(2S)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine, ¦ (E)-(2S)-[3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl}-dimethylamine or ¦ (Z,E)- (2S)- [3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine. 71. Process as claimed in claim 56, wherein chiral centre is present in the compound according to formula III employed, at position 2 according to formula III. 72. Process as claimed in claim 56, wherein chiral centre is present in the compound according to formula I, at position 2 according to formula I. 73. Process as claimed in claim 56 ,wherein the compound according to formula III employed is enantiomerically pure. 74. Process as claimed in claim 56, wherein the compound according to formula III employed is diastereomerically pure. 75. Process as claimed in claim 56, wherein the compound according to formula III employed is enantiomerically and diastereomerically pure. 76. Process as claimed in claim 56, wherein the compound according to formula III employed is chosen from: • (Z) - (2R) - [3-(3-methoxy-phenyl)-2-methyl-pent-3-enyl]- dimethylamine, • (E) - (2R) - [3-(3-methoxy-phenyl)-2-methyl-pent-3-enyl]- dimethylamine or is a mixture of (2)-(2R) - [3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine and (E)-(2R)-[3-(3-methoxy-phenyl)-2- methyl-pent-3-enyl]-dimethylamine, or (Z,E)-(2R)-[3-(3-methoxy- phenyl)-2-methyl-pent-3-enyl]-dimethylamine. 77. Process as claimed in claim 56, wherein the compound according to formula III employed is chosen from: • (Z) - (2S) - [3-(3-methoxy-phenyl)-2-methyl-pent-3-enyl]- dimethylamine, • (E) - (2S) - [3-(3-methoxy-phenyl)-2-methyl-pent-3-enyl]- dimethylamine or is a mixture of (Z)-(2S) - [3-(3-methoxy-phenyl)-2-methyl-pent-3- enyl]-dimethylamine and (E)-(2S)-[3-(3-methoxy-phenyl)-2- methyl-pent-3-enyl]-dimethylamine, or (Z,E)-(2S)-[3-(3-methoxy- phenyl)-2-methyl-pent-3-enyl]-dimethylamine. 78. Process as claimed in claim 56, wherein the solvent is chosen from: H2O or alcohol or aqueous alcoholic or aqueous acidic solutions, preferably from aqueous acidic solutions. 79. Process as claimed in claim 56, wherein the solvent is chosen from: H2O or ethanol or aqueous ethanolic solution or aqueous hydrochloric acid, preferably from aqueous hydrochloric acid. 80. Process as claimed in claim 56, wherein the catalyst used comprises a noble metal, preferably platinum, gold or palladium, in particular palladium. 81. Process as claimed in claim 80, wherein the catalyst used in palladium-on-active charcoal or palladium(II) chloride. 82. Process as claimed in claim 80, wherein the catalyst used is palladium-on-active charcoal (1-10 wt.%, preferably 5 wt.%). 83. Process as claimed in claim 56, wherein the temperature is kept between 20 and 40°C, preferably between 20 and 35, in particular 25°C. 84. Process as claimed in claim 56, wherein an inert gas atmosphere, in particular a nitrogen inert gas, is applied before the hydrogenation. 85. Process as claimed in claim 56, wherein the hydrogenation step takes place under a hydrogen pre-pressure of 3-10 bar, preferably 4-7 bar, in particular 5 bar. and/or the hydrogenation step takes place under a hydrogen internal pressure of 0.5-3 bar, preferably 0.75-2 bar, in particular 1 bar. 86. Process as claimed in claim 56, wherein the starting substances are highly dilute/diluted in the solvent at the start. 87. Process as claimed in claim 56, wherein the compound according to formula III employed is dissolved in aqueous acid. 88. Process as claimed in claim 87, wherein the compound according to formula III employed is dissolved in aqueous hydrochloric acid. 89. Process as claimed in one of claims 1 or 56, wherein the products are precipitated in an organic solvent at the end of the process. 90. Process as claimed in one of claims 1 or 56, wherein the products are precipitated with acid or acid gas, preferably hydrochloric acid or hydrochloric acid gas, in particular hydrochloric acid gas, at the end of the process. 91. Process as claimed in one of claims 1 or 56, wherein the products are precipitated in an organic solvent with acid or acid gas, preferably hydrochloric acid or hydrochloric acid gas, in particular hydrochloric acid gas, at the end of the process. The present invention relates to a process for the dehydration of substituted 1-amino-3-aryl-butan-3-ol compounds for the preparation of substituted 3- aryl-butyl-amine compounds. |
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| Patent Number | 223817 | ||||||||||||||||||||||||||||||
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| Indian Patent Application Number | 02307/KOLNP/2005 | ||||||||||||||||||||||||||||||
| PG Journal Number | 39/2008 | ||||||||||||||||||||||||||||||
| Publication Date | 26-Sep-2008 | ||||||||||||||||||||||||||||||
| Grant Date | 23-Sep-2008 | ||||||||||||||||||||||||||||||
| Date of Filing | 18-Nov-2005 | ||||||||||||||||||||||||||||||
| Name of Patentee | GRUNENTHAL GMBH, | ||||||||||||||||||||||||||||||
| Applicant Address | GERMANY ZIEGLERSTRASSE 6, 52078 AACHEN | ||||||||||||||||||||||||||||||
Inventors:
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| PCT International Classification Number | C07C 217/62 | ||||||||||||||||||||||||||||||
| PCT International Application Number | PCT/EP2004/006027 | ||||||||||||||||||||||||||||||
| PCT International Filing date | 2004-06-04 | ||||||||||||||||||||||||||||||
PCT Conventions:
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