Title of Invention	FUNGICIDES BASED ON NITROGEN-CONTAINING HETEROCYCLES
Abstract	A compound of the general formula (I) which is concerned with the provision of novel pyridotriazines for combating phytopathogenic diseases on plants and harvested food crops.

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FUNGICIDES BASED ON NITROGEN-CONTAINING HETEROCYCLES This invention relates to novel derNatNes of pyridotriazines, to processes for preparing them, to certain intermediate chemicals used in their manufacture, to compositions containing them and to methods of using them to combat fungi, especially fungal infections of plants. DerNatNes of the nitrogen-containing 5,6 ring system s-l,2,4-triazolo[l,5-a]pyri-midine are known from the patent literature as being useful for controlling phytopathogenic fungi. Examples of recent patent publications include EP-A-1249452, WO 02/051845, WO 02/083676, WO 02/083677, WO 02/0SS125, WO 02/088126, WO 02/0S8127. The present invention is concerned with the provision of novel pyridotriazines for combating phytopathogenic diseases on plants and harvested food crops. Thus, according to the present invention, there is provided a compound of the general formula (1): wherein W, Z and one of X and Y are N and the other one of X and Y is CR8; R8 is H, halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio or halo(C1-4)alkyl; R and R are independently H, halo, C1-8alkyl, C1-8 alkoxy,C1-8 alkylthio, C2-8 alkenyl, C2-8 alkynyl, cyano or NR3R4, provided that at least one ofR and R2 is NR3R4; R1 is halo, C1-8alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-8 cycloalkyl, C3-8 cycloalkyl(C1-6)alkyl, C1-8alkoxy, C1-8alkylthio, aryl, aryloxy, arylthio, heteroaryl, heteroaryloxy, heteroarylthio, aryl(C1-4)alkyl, aryl(C1-4)alkoxy, heteroaryl(C1-4)alkyl, heteroaryl(C1-4)alkoxy, aryl(C1-4)alkyl- thio, heteroarYL ,l(C1-4)alkylthio, morpholino, piperidino or pyrrolidino; R3 and R4 are independently H,C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, aryl, aryl(C1-8)alkyl, C3-8 cycloalkyl, C3-8cycloalkyl(C1-6)alkyl, heteroaryl, heteroaryl(C1-8)alkyl, NR5R6, provided that not both R3 and R4 are H or NR5R6, or R3 and R4 together form a C3-7 alkylene or C3-7 alkenylene chain together with the nitrogen atom to which they are attached, R and R foR"" a morpholine, thiomorpholine, thiomorpholine S-oxide or thiomorpholine S-dioxide ring or a piperazine or piperazine N-(C1-4)a\kyl (especially NN-methyl) ring: and R5 and R6 are independently H, C1-8alkyl, C2-8 alkenyl, C2-8alkynyl, aryl, aryl(C1-8)alkyl,C3-8 cycloalkyl, C3-8cycIoalkyl(C1-6)aIkyl, heteroaryl or heteroaryl(C1-8)alkyl; any of the foregoing alkyl, alkenyl, alkynyl or cycloalkyl groups or moieties (other than for R ) being optionally substituted with halogen, cyano, C1-6alkoxy, C1-6alkylcarbonyl, C1-6 alkoxycarbonyl, C1-6 haloalkoxy, C1-6 alkylthio, tri(C1-4)alkylsilyl, C1-6 alkylamino or C1-6 dialkylamino, any of the foregoing morpholine, thiomorpholine, piperidine, piperazine and pyrrolidine rings being optionally substituted with C1-4 alkyl (especially methyl), and any of the foregoing aryl or heteroaryl groups or moieties being optionally substituted with one or more substituents selected from halo, hydroxy, mercapto, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6alkoxy, C2-6 alkenyloxy, C2-6 alkynyloxy, haIo(C1-6)alkyl, halo(C1-6)alkoxy, C1-6 alkylthio, halo(C1-6)alkylthio, hydroxy(C1-6)alkyl, C1-4 alkoxy(C1-6)alkyl, C3-6 cycloalkyl, C3-6 cycloalkyl(C1-4)alkyl, phenoxy, benzyloxy, benzoyloxy, cyano, isocyano, thiocyanato, iso- thiocyanato, nitro, -NR""R"", -NHCOR'", -NHCONR""R"", -CONR""R"", -S02R"", -OS02R"", -COR'", -CR""=NR,," or -N=CR"'R"", in which R"" and R," are independently hydrogen, C1-4 alkyl, halo(C1-4)alkyl, C1-4 alkoxy, halo(C1-4)alkoxy, C1-4 alkylthio, C3-6 cycloalkyl, C3-6 cycloalkyl(C1-4)alkyl, phenyl or benzyl, the phenyl and benzyl groups being optionally substituted with halogen, C1-4 alkyl or C1-4 alkoxy. • The invention includes a compound of the general foR""ula (1) as defined immediately above except that: C1-4 alkoxy and C1-8 alkylthio are excluded as values of R and R ; C7 alkylene and C3-7 alkenylene are excluded as chains foR""ed by R3 and R4; the C3-6 chain that R3 and R4 may foR"" may only be optionally substituted with one or more methyl groups; thiomorpholine, thiomorpholine S-oxide, thiomorpholine S-dioxide and piperazine are excluded as rings that R- and R4 may foR""; tri(C1-4)alkylsilyl is excluded as a substituent of any alkyl, alkenyl, alkynyl or cycloalkyl group or moiety; any morpholine, piperidine or pyrrolidine ring is unsubstituted and C1-4 alkylthio is excluded as a value of R8. The compounds of the invention may contain one or more asymmetric carbon atoms and may exist as enantiomers (or as pairs of diastereoisomers) or as mixtures of such. They may also exist as diastereoisomers by virtue of restricted rotation about a bond. However, mixtures of enantiomers or diastereoisomers may be separated into indNidual isomers or isomer pairs, and this invention embraces such isomers and mixtures thereof in all proportions. It is to be expected that for any gNen compound, one isomer may be more fungicidally actNe than another. Except where otherwise stated, alkyl groups and alkyl moieties of alkoxy, alkylthio, etc., contain from 1 to 8, suitably from 1 to 6 and typically from 1 to 4, carbon atoms in the foR"" of straight or branched chains. Examples are methyl, ethyl, NN- and iso-pvopyl, n-. sec-, iso- and ten-butyl, n-pentyl and /z-hexyl. Cycloalkyl groups contain from 3 to S, typically from 3 to 6, carbon atoms and include bicycloalkyl groups such as the bicyclo[2.2.1]heptyl group. Haloalkyl groups or moieties are typically trichloromethyl or trifiuoromethyl or contain a trichloromethyl or trifiuoromethyl teR""inal group. Except where otherwise stated, alkenyl and alkynyl moieties also contain from 2 to S, suitably from 2 to 6 and typically from 2 to 4, carbon atoms in the foR"" of straight or branched chains. Examples are allyl, 2-methylallyl and propargyl. Optional substituents include halo, typically fluoro. An example of halo-substituted alkenyl is 3,4,4-trifluoro-/i-butenyh" Halo includes fluoro, chloro, bromo and iodo. Most commonly it is fluoro, chloro or bromo and usually fluoro or chloro. Aryl is usually phenyl but also includes naphthyl, anthryl and phenanthryl. Heteroaryl is typically a 5- or 6-membered aromatic ring containing one or more O, N or S heteroatoms, which may be fused to one or more other aromatic or heteroaromatic rings, such as a benzene ring. Examples are thienyl, furyl, pyrrolyl, isoxazolyl, oxazolyl, oxadiazolyl, pyrazolyl, imidazolyl, triazolyl, isothiazolyl, tetrazolyl, thiadiazolyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, triazinyl, benzofuryl, benzothienyl, dibenzofiiryl, benzothiazolyl, benzoxazolyl, benzimidazolyl, indolyl, quinolinyl and quinoxalinyl groups and, where appropriate, N-oxides thereof. The 6,6-ring systems embraced by the general foR""ula (1) are pyrido[2,3-e][ 1,2,4]-triazines (where Y is CR and W, X and Z are all N) and pyrido[3,2-e][l,2,4]triazines (where X is CR8 and W, Y and Z are all N). R8 is H, halo (for example bromo), C1-4 alkyl (for example methyl), C1-4 alkoxy (for One of R and R2, preferably R2, is NR3R4. The other is typically halo, especially chloro or fluoro. The more actNe compounds are usually those where R is NR R . R is typicallyC1-8 alkyl (for example ethyl,Ni-propyl, n-butyl, sec-butyl (the S- or R-isomer or the racemate) and terr-butyl), halo(C1-8)alkyl (for example 2,2,2-trifluoroethyl, 2,2,2-trifluoro-l-methylethyl (the S- or R-isomer or the racemate), 3?3,3-trifluoropropyl and 4,4,4-trifluorobutyl), hydroxy(C1-8)alkyl (for example hydroxyethyl). C1-4 alkoxy(C1-8)alkyl (for example methoxymethyl and methoxy-wobutyl), C1-4 alkoxyhalo(C1-8)alkyl (for example 2-methoxy-2-trifluromethylethyl), tri(C1-4)alkylsilyl(C1-6)alkyl (for example trimethylsHylmethyl), C1-4 alkylcarbonyl(C1-8)alkyl (for example 1-acetylethyl and l-tert-butylcarbonylethyl), C1-4 alkylcarbonylhalo(Ci,s)alkyl (for example l-acetyl-2,2,2-trifluoroethyl), phenyl(i-4)alkyl (for example benzyl), C2-8 alkenyl (for example allyl and methylallyl), halo(C2-8)alkenyl (for example 3-methyl-4,4-difluorobut-3-enyl), C2.3 alkynyl (for example propargyl), C3-8 cycloalkyl (for example cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl) optionally substituted with chloro, fluoro or methyl, C3-8 cycloalkyl(C1-4)-alkyl (for example cyclopropylmethyl, cyclobutylmethyl, cyclopentylmethyl and cyclohexylmethyl), phenylamino, piperidino or morpholino, the phenyl ring of phenylalkyl or phenylamino being optionally substituted with one, two or three substituents selected from halo (typically fluoro, chloro orbromo), C1-4 alkyl (typically methyl), halo(C1-4)alkyl (typically trifluoromethyl), C1-4 alkoxy (typically methoxy) and halo(C1-4)alkoxy (typically trifluoromethoxy). R4 is typically H, C1-4 alkyl (for example ethyl and N-propyl), haIo"(C1-4)-alkyl (for example 2,2,2-trifluoroethyl) or amino. AlternatNely R3 and R4 together foR"" a C4-6 alkylene chain optionally substituted with methyl, for example 3-methylpentylene, or, together with the nitrogen atom to which they are attached, R3 and R4 foR"" a morpholine, thiomorpholine, thiomorpholine S-oxide or thiomorpholine S-dioxide ring or a piperazine or piperazine N-(C1-6alkyl (especially TV-methyl) ring, in which the morpholine or piperazine rings are optionally substituted with methyl. Typically R1 is phenyl optionally substituted with from one to fNe halogen atoms, particularly fluorine and chlorine atoms and especially fluorine atoms or with from one to three substituents selected from halo (for example fluoro and chloro), C1-4 alkyl (for example methyl), halo(C1-4)alkyl (for example trifluoromethyl), C1-4 alkoxy (for example methoxy) or halo(C].4)alkoxy (for example trifluoromethoxy). Examples are 2,6-difluorophenyl, 2-fluoro-6-chlerophenyl, 2,5,6-trifluorophenyl, 2,4,6-trifluorophenyl, 2,6-difluoro-4-methoxyphenyl, pentafluorophenyl, 2-fluorophenyl, 2,3,5,6-tetrafluoropheny], 2-chloro-4,6-difluorophenyl, 2-chlorophenyl, 2,6-dichlorophenyl, 2,4-dichlorophenyl, 2,4,6-trichlorophenyL 2,3,6-trichloro-phenyl pcntachlorophenyl, 2-fluoro-4,6-dichlorophenyI, 4-fluoro-2,6-dichlorophenyl, 2-bromophenyl, 2-fluoro-6-bromophenyK 2-bromo-4,6-difluorophenyl, 2-fluoro-6-methyl-phenyl, 2-chloro-6-methyIphenyl, 2-methoxyphenyI, 2,6-dimethoxyphenyI. 2-fluoro-6-methoxyphenyl, 2-trifluoromethylphenyl, 2-fluoro-6-triflu6romethylphenyl, 2,6-di-(trifluoro-methyl)phenyk 2-chloro-6-trifluoromethylphenyl, 2,4-difluoro-6-trifluoromethylphenyl, 2,4-difluoro-6-methoxyphenyl and 2,4-difluoro-6-methylphenyl. Also of particular interest are compounds where R1 is pyridyl optionally substituted with from one to four halogen atoms or with from one to three substituents selected from halo (for example fluoro and chloro), C1-4 alkyl (for example methyl), halo(C1-4)alkyl (for example trifluoromethyl), C1-4 alkoxy (for example methoxy) or halo(C1-4)a!koxy (for example trifluoromethoxy). Examples are 2,4-difluoropyrid-3-yl, 3,5-difluoropyrid-4-yI, tetrafluoropyrid-4-yl, 3-fluoropyrid-2-yl, 4-fluoropyrid-3-yl, 3-fluoropyrid-4-yl, 2-fluoro-pyrid-3-yl, 2,4,6-trifluoropyrid-3-yl, 3,5-difluoropyrid-2-yl, 2J6-difluoropyrid-3-yl, 2,4-difluoro-6-methoxypyrid-3-yl, 2-fluoro-4-chloropyrid-3-yl, 3-fluoro-5-chloropyrid-4-yl, 2-chloro-4-fluoropyrid-3-yl, 2,4-dichloropyrid-3-yl, 3-chloropyrid-2-yl I, 4-chloropyrid-3-yl, 3-chloropyrid-4-yl, 2-chloropyrid-3-yl, 3-trifluoromethylpyrid-2-yl, 4-trifluoromethylpyrid-3-yl, 3,5-dichloropyrid-2-yl, 4,6-dichloropyrid-3-yl, 3-trifluoromethylpyrid-4-yh 2-trifluoro-. methylpyrid-3-yl, 2-fluoro-4-trifluoromethylpyrid-3-yl, 3-fluoro-5-trifluoromethylpyrid-4-yl, 4-fluoro-2-trifluoromethylpyrid-3-yl, 2,6-dichloropyrid-3-yl, 3,5-dichloropyrid-4-yl, 3-chloro-6-trifluoromethylpyrid-2-yl, 3-fluoro-6-trifluoromethylpyrid-2-yl, pyrid-2-yI, pyrid-3-yl and pyrid-4-yl. Also of particular interest are compounds where R1 is 2- or 3-thienyI optionally substituted with from one to three halogen atoms or with from one to three substituents selected from halo (for example fluoro and chloro), C1-4 alkyl (for example methyl), halo-(C1-4)alkyl (f°r example trifluoromethyl), C1-4 alkoxy (for example methoxy) or halo(C1-4)-alkoxy (for example trifluoromethoxy). Examples are 3-fluorothren-2-yl, 3-chIorothien-2-yI, 2,4-difluorothiej}-3-yl, 2,4-dichlorothien-3-yl and 2,4,5-trichlorothien-3-yl. Examples of other values of R of especial interest are unsubstituted piperidino and In one aspect the invention provides a compound of the general foR""ula (1) wherein W, Z and one of X and Y are N and the other one of X and Y is CR ; R is H, halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio or halo(C1-4)alkyl; one of R and R3 (preferably R2) is NR3R4 and the other is halo; R1 is halo, C1-8 alkyl, C2-8 alkenyl. C1-4 alkynyl, C3-8 cycloalkyl, C3-8cycloalkyl(C1-6)alkyl, C1-3 alkoxy,C1-8 alkylthio, aryl, aryloxy, arylthio, heteroaryl, heteroaryloxy, heteroarylthio, aryl(C1-4)alkyl, aryl(C1-4)alkoxy, heteroaryl(C1-4)alkyl, heteroaryl(C1-4)alkoxy, aryl(C1-4)alkyl- thio, heteroaryl(C1-4)alkylthio, morpholino, piperidino or pyrrolidino; R3 and R4 are independently H, C1-8alkyl, C2-8 alkenyl, C2-8 alkynyl,'aryl, aryl(Ci-8)alkyl, C3-8 cycloalkyl, C3-8cycIoalkyl(C1-6)alkyl, heteroaryl, heteroaryl(C1-8)alkyl, NRDR6, provided that not both R3 and R4 are H 01NR5R6, or R3 and R4 together foR"" a C3-7 alkylene or C3.7 alkenylene chain optionally substituted with one or more C1-4 alkyl or C1-4 alkoxy groups, or, together with the nitrogen atom to which they are attached, R3 and R4 foR"" a morpholine, thiomorpholine, thiomorpholine S-oxide or thiomorpholine S-dioxide ring or a piperazine or piperazine N-(C1-4)alkyl (especially vV-methyl) ring; and R5 and R6 are independently H, C1-8alkyl, C2-8 alkenyl, C2-8 alkynyl, aryl, aryl(Ci-.s)alkyl, C3-8 cycloalkyl, C3-8 cycloalkyI(C1-6)alkyl, heteroaryl or heteroaryl(C1-8)alkyl; any of the foregoing alkyl, alkenyl, alkynyl or cycloalkyl groups or moieties (other than for R ) being optionally substituted with halogen, cyano, C1-6 alkoxy, C1-6 alkylcarbonyl, C1-4 alkoxycarbonyl, C1-4 haloalkoxy, Cue alkylthio, tri(C1-6)alkylsilyl, C1-4 alkylaminp or dialkylamino, any of the foregoing morpholine, thiomorpholine, piperidine, piperazine and pyrrolidine rings being optionally substituted with C1-4 alkyl (especially methyl), and any of the foregoing aryl, heteroaryl, aryloxy or heteroaryl groups being optionally substituted with one or more substituents selected from halo, hydroxy, mercapto, C1-4 alkyl, > C2-6 alkenyl, C2-6 alkynyl, C1-4 alkoxy, C2-6 alkenyloxy, C2-6 alkynyloxy, halo(C1-6)alkyl, ha!o(C1-6)alkoxy, C1-4 alkylthio, halo(C1-6)alkylthio, hydroxy(C1-6)alkyl, C1-4 alkoxy(C1-4)- alkyl, C3-6 cycloalkyl, C3-6 cycloalkyl(C1-4)alkyl, phenoxy, benzyloxy, benzoyloxy, cyano, isocyano, thiocyanato, isothiocyanato, nitro, -NR"'R"" -NHCOR"", -NHCONR',R," -CONR"'R"",-S02R"", -OS02R"", -COR", -CR'^NR"" or -N=CR'"R"",in which R"" and R" are independently hydrogen, C1-4 alkyl, halo(C1-4)alkyl, alkoxy, halo(C1-4)alkoxy, C1-4 alkylthio, C3-6 cycloalkyl, C3-6 cycloalkyl(C1-4)alkyl, phenyl or benzyl, the phenyl and benzyl groups being optionally substituted with halogen, C1-4 alkyl or C1-4 alkoxy. Of particular interest are compounds where R is H. The invention includes a compound of the general foR""ula (1) as defined immediately above except that: C7 alkylene and C3.7 alkenylene are excluded as chains foR""ed by R"1 and R4; the C3-6 chain that R and R4 may foR"" may only be optionally substituted with one or more methyl groups; thiomorpholine, thiomorpholine S-oxide, thiomorpholine S-dioxide and piperazine are excluded as rings that R and R4 may foR""; tri(C1-4)alkylsilyl is excluded as a substituent of any alkyl, alkenyl, alkynyl or cycloalkyl group or moiety; any morpholine, piperidine or pyrrolidine ring is unsubstituted and C1.4 alkylthio is excluded as a value of R . In another aspect the invention provides a compound of the general foR""ula (1) wherein W, Z and one of X and Y are N and the other one of X and Y is CR ; R8 is H, halo, C1-4 alkyl* C1-4 alkoxy, C1-4 alkylthio or halo(C1-4)alkyl; one of R and R" (preferably R ) is MR R and the other is halo; R1 is halo,C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-8 cycloalkyl,C3-8cycloalkyI(C1-6)alkyl, C1-8 alkoxy, C1-8 alkylthio, aryl, aryloxy, arylthio, heteroaryl, heteroaryloxy, heteroarylthio, aryl(C1-4)alkyl, aryl(C1-4)alkoxy,.heteroaryl(C1-4)alkyl, heteroaryl(C1-4)alkoxy, aryl(C1-4)alkyl-thio, heteroaryl(C1-4)alkylthio, morpholino, piperidino orpyrrolidino; R3 is C1-4 alkyl, halo(C1-4)alkyl, C2-4 alkenyl, C3-6 cycloalkyl, C3-6 cycloalkyl(C1-4)alkyl or phenylamino in which the phenyl ring is optionally substituted with one, two or three subs-tituents selected from halo, C1-4 alkyl, halo(C1-6)alkyl, C1-4 alkoxy and halo(C1-4)alkoxy; and R4 is H, C1-4 alkyl or amino, or R3 and R4 together foR"" a C4-6 alkylene chain optionally substituted with C1-4 alkyl or C1-4 alkoxy, or, together with the nitrogen atom to which they are attached, R3 and R4R"" a morpholine, thiomorpholine, thiomorpholine S-oxide or thiomorpholine S-dioxide ring or a piperazine or piperazine N-(C1-4)alkyl (especially N-methyl) ring; any of the foregoing alkyl, alkenyl, alkynyl or cycloalkyl groups or moieties (other than for R8) being optionally substituted with halogen, cyano, C1-6alkoxy, C1-6 alkylcarbonyl, C1-6"" any of the foregoing morpholine, thiomorpholine, piperidine, piperazine and pyrrolidine rings being optionally substituted with C1-4 alkyl (especially methyl), and any of the foregoing aryl or heteroaryl groups or moieties being optionally substituted with one or more substituents selected from halo, hydroxy, mercapto, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C2-6 alkenyloxy, C1-6 alkynyloxy, halo(C1-6)alkyl, halo(C1-6)alkoxy, C1-6alkylthio, halo(C1-6)alkylthio, hydroxy(C1-6)aIkyl C1-4alkoxy(C1-6)alkyl, C3-6 cycloalkyl, C3-6 cycloalkyl(C1-4)alkyl, phenoxy, benzyloxy, benzoyloxy, cyano, isocyano, thiocyanato, iso-thiocyanato, nitro, -NR,HR"", -NHCOR'", -NHCONR"'R'",-CONR,"R"", -S02R",-OS02R",-COR",-CRW=NR"" or -N=CRWR"", in which R"" and R"" are independently hydrogen, C1-4 alkyl, halo(C1-4)alkyl, C1-4 alkoxy, halo(C1-4)alkoxy, C1-4 alkylthio, C3-6 cycloalkyl, cycloalkyl(C1-4)alkyl, phenyl or benzyl, the phenyl and benzyl groups being optionally substituted with halogen, C1-4 alkyl or C1-4 alkoxy. Of particular interest are compounds where R is H. The invention includes a compound of the general foR""ula (1) as defined immediately above except that: the C4-6 chain that R3 and R4 may foR"" may only be optionally substituted with methyl; thiomorpholine, thiomorpholine S-oxide, thiomorpholine S-dioxide and piperazine are excluded as rings that R and R4 may foR""; tri(C1-4)alkylsilyl is excluded as a substituent of any alkyl, alkenyl alkynyl or cycloalkyl group or moiety; any morpholine, piperidine or pyrrolidine ring is unsubstituted and C1-4 alkylthio is excluded as a value of R . In yet another aspect the invention provides a compound of the general foR""ula (1) wherein W, Z and one of X and Y are N and the other one of X and Y is CR8; R8 is H, halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio or halo(C1-4)aIkyl; R and R2 are independently H, halo, Cj.g alkyl, C1-8 alkoxy, C1-8alkylthio, C2-8 alkenyl, C2-8 alkynyl, cyano or NR3R4, provided that at least one of R and R2 (preferably R2) is NR3R4; R1 is optionally substituted phenyl; R and R are independently H, C1-8alkyl, C2-8 alkenyl, C2-8 alkynyl, aryl, aryl(Ci.s)alkyl, C3-8 cycloalkyl, C3_8cycloalkyl(C1-6)alkyl; heteroaryl, heteroaryl(C1-8)alkyl, NR5R6, provided that not both R3 and R4 are H or NR5R6, or R3 and R4 together foR"" a C3-7 alkylene or C3.7 alkenylene chain optionally substituted with one or more C1-4 alkyl or C1-4 alkoxy groups, or, together with the nitrogen atom to which they are attached, R3 and R4 foR"" a morpholine. thiomorpholine, thiomorpholine S-oxide or thiomorpholine S-dioxide ring or a piperazine or piperazine7V-(C1-4)aIkyl (especially yV-methyl) ring; and R/5 and Rb are independently H, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, aryl, aryl(C1-8)alkyI, C3-8 cycloalkyl,C3-8cycloalkyl(Ci-6)alkyl, heteroaryl or heteroaryl(C|.8.)aIkyI; any of the foregoing alkyl, alkenyl, alkynyl or cycloalkyl groups or moieties (other than for R8) being optionally substituted with halogen, cyano. C1-4 alkoxy, C1-6alkylcarbonyl, C1-6 alkoxycarbonyl,C1-6 haloalkoxy, C1-4 alkylthio, tri(C1-6)alkylsilyl, C1-4 alkylaminoor C1-4 dialkylamino, any of the foregoing morpholine, thiomorpholine, piperidine, piperazine and pyrrolidine rings being optionally substituted with C1-4 alkyl (especially methyl), and any of the foregoing aryl or heteroaryl groups or moieties, including Jhe phenyl group of R1, being optionally substituted with one or more substituents selected from halo, hydroxy, mercapto, C1-4 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-4 alkoxy, C2-6 alkenyloxy, C2-6 alkynyloxy, halo(C1-6)alkyI, halo(Cj.6)alkoxy, C1-4 alkylthio, halo(C1-6)alkylthio, hydroxy(C1-6)alkyl, C1-4 alkoxy(C1-6)alkyl, C3-6 cycloalkyl, C3-6 cycloalkyl(C1-4)alkyl, phenoxy, benzyloxy, benzoyl- oxy, cyano, isocyano, thiocyanato, isothiocyanato, nitro, -NRf"R"", -NHCOR'", -NHCONR""R"", -CONR'"R"", -S02R"", -OS02R,H, -COR"', -CR""=NR"" or-N=CR,rfR"", in which R"f and R"" are independently hydrogen, C1-4 alkyl, halo(C1-4)alkyl C1-4 alkoxy, halo- (C1-6)alkoxy, C1-4 alkylthio, C3-6 cycloalkyl, C3-6 cycloalkyl(C1-4)alkyl, phenyl or benzyl, the 1 phenyl and benzyl groups being optionally substituted with halogen, C1-4 alkyl or C1-4 alkoxy. Q Of particular interest are compounds where R is H. The invention includes a compound of the general foR""ula (1) as defined immediately above except that: C1-8alkoxy and C1-8 alkylthio are excluded as values of R and R"; C7 alkylene and C3.7 alkenylene are excluded as chains foR""ed by R3 and R4; the C3-6 chain that R3 and R4 may foR"" may only be optionally substituted with one or more methyl groups; thiomorpholine, thiomorpholine S-oxide, thiomorpholine S-dioxide and piperazine are excluded as rings that R3 and R4 may foR""; tri(C1-4)alkylsilyl is excluded as a substituent of any alkyl, alkenyl, alkynyl or cycloalkyl group or moiety; the morpholine ring that R3 and R4 may foR"" is unsubstituted and C1-4 alkylthio is excluded as a value of R8. In still yet another aspect the invention provides a compound of the general foR""ula (1) wherein W, Z and one of X and Y are N and the other one of X and Y is CR8; R8 is H, halo (e.g. fluoro, chloro or bromo), C1-4 alkyl (e.g. methyl). C1-4 alkoxy (e.g. methoxy), C1-4 alkylthio (e.g. methylthio) or haIo(C1-4)alkyl (e.g. trifluorometbyl); R isH, halo (e.g. fluoro, chloro or bromo). C1-4 alkyl (e.g. methyl), C1-4 alkoxy (e.g. methoxy) orcyano; R1 is phenyl optionally substituted with from one to fNe halogen atoms or with from one to three substituents selected from halo, C1-4 alkyl, halo(C1-4)alkyl, C1-4 alkoxy or halo(C1-4)- alkoxy, pyridyl optionally substituted with from one to four halogen atoms or with from one to three substituents selected from halo, C1-4 alkyl, halo(C1-4)alkyl, C1-4 alkoxy or haIo(C1-4)- alkoxy, 2- or 3-thienyl optionally substituted with from one to three halogen atoms or with from one to three substituents selected from halo, C1-4 alkyl, halo(C1-4)alkyl, C1-4 alkoxy or halo(C1-4)aIkoxy, or piperidino or morpholino both optionally substituted with one or two methyl groups; R2 is NR3R4; R3 is Cj-8 alkyl, haIo(Ci-8)alkyl, hydroxy(Ci-8)alkyl, C1-4 alkoxy(C1-8)alkyI, C1-4 alkoxyhalo- (C1-8)alkyl, tri(C1-4)alkylsilyI(C1-6)aIkyl, C1-4 alkylcarbonyi(C1-8)alkyl, C1-4 alkylcarbonyl- hald(C1-8)alkyl, phenyl(M)aIkyl, C2-8 alkenyl, halo(C:-8)alkenyl, C2-8 alkynyl, C3-8 cycloalkyl optionally substituted with chloro, fluoro or methyl, C3-8 cyc!oalkyl(C1-4)alkyl, phenylamino, piperidino or morpholino, the phenyl ring of phenylalkyl or phenylamino being optionally substituted with one, two or three substituents selected from halo, C1-4 alkyl, halo(C1-4)alkyl, C1-4 alkoxy and halo(C1-4)alkoxy; and R4 is H, C1-4 alkyl halo(C1-4)alkyl or amino, or R3 and R4 together foR"" a C3-7 alkylene or C3.7 alkenylene chain optionally substituted with methyl, or, together with the nitrogen atom to which they are attached, R and R foR"" a morpholine, thiomorpholine, thiomorpholine S-oxide or thiomorpholine S-dioxide ring or a piperazine or piperazine N-(C1-4)alky,(especially TV-methyl) ring, in which the morpholine or piperazine rings are optionally substituted with methyl. Of particular interest-are compounds where R is H. In still yet another aspect the invention provides a compound of the general foR""ula (1) wherein W, Z and one of X and Y are N and the other one of X and Y is CR8; R8 is H, halo, Cj^aHcyl, C1-4 alkoxy or halo(C1-4)alkyl; R is halo; R! is phenyl optionally substituted with from one to fNe halogen atoms or with from one to three substituents selected from halo, C1-4 alkyl, halo(C1-4)alkyl, C1-4 alkoxy or halo(C1-4)- alkoxy; R2 is NR3R4; R3 is C1-4 alkyl, halo(C1-4)alkyl, C2.4 alkenyl. C3-6 cycloalkyl, C3-6 cycloalkyl(C1-4)alkyl or phenylamino in which the phenyl ring is optionally substituted with one, two or three substituents selected from halo, C1-4 alkyl, halo(C1-4)alkyl, C1-4 alkoxy and halo(C1-4)alkoxy; and R is H, C1-4 alkyl or amino, or R" and R5 together foR"" a C4-6 alkylene chain optionally substituted with methyl, or, together with the nitrogen atom to which they are attached, R3 and R4 foR"" a moipholine ring. Of particular interest are compounds where R5 is H. Compounds that foR"" part of the invention are illustrated in Tables 1 to 130 below. Characterising data are gNen later in the Examples and in Table 136. In Table 1 the compounds have the general foR""ula (1 A), where W, X and Z are N ' and Y is CH, R is CI, Rl is 2,4,6-trifluorophenyl and R3 and R4 are as shown in the table. Table 2 Table 2 consists of 662 compounds of the general foR""ula (1 A), where W, X and Z are N and Y is CH, R is CI, R1 is 2,5,6-trifluorophenyI, and the values of R3 and R4 are as listed in Table 1. Thus, compound 1 of Table 2 is the same as compound 1 of Table 1. except that in compound 1 of Table 2, R1 is 2,5,6-trifluorophenyI. Similarly, compounds 2 to 662 of Table 2 are the same as compounds 2 to 662 of Table 1 except that in the compounds of Table 2, Rl is 2,5,6-trifluorophenyl. Table 3 Table 3 consists of 662 compounds of the general foR""ula (1A), where W, X and Z are N and Y is CH, R is CI, R1 is 2,3,4,5,6-pentafluorophenyl, and the values of R3 and R4 are as listed in Table 1. Thus, compound 1 of Table 3 is the same as compound 1 of Table 1 except that in compound 1 of Table 3, R1 is 2,3,4,5.6-pentafluorophenyl. Similarly, compounds 2 to 662 of Table 3 are the same as compounds 2 to 662 of Table 1 except that in the compounds of Table 3, R1 is 2,3,4,5,6-pentafluorophenyl. Table 4 Table 4 consists of 662 compounds of the general foR""ula (1 A), where W, X and Z are N and Y is CH, R is CI, R1 is 2,6-difluoro-4-methoxyphenyI, and the values of R3 and R4 are as listed in Table 1. Thus, compound 1 of Table 4 is the same as compound 1 of Table 1 except that in compound 1 of Table 4, R1 is 2,6-difluoro-4-methoxyphenyL Similarly, compounds 2 to 662 of Table 4 are the same as compounds 2 to 662 of Table 1 except that in the compounds of Table 4, R1 is 2,6-difluoro-4-methoxyphenyl. Table 5 Table 5 consists of 662 compounds of the general foR""ula (1A), where W, X and Z are N and Y is CH, R is CI, R1 is 2-fluon>6-chlorophenyl, and the values of R3 and R4 are as listed in Table I. Thus, compound 1 of Table 5 is the same as compound 1 of Table 1 except that in compound 1 of Table 5, Rl is 2-fluoro-6-chlorophenyl. Similarly, compounds 2 to 662 of Table 5 are the same as compounds 2 to 662 of Table 1 except that in the compounds of Table 5, R1 is 2-fluoro-6-chlorophenyl. Table 6 consists of 662 compounds of the general foR""ula (IB), where W, X and Z are N and Y is CH, R is CI, R1 is 2,4,6-trifluorophenyl, and the values of R3 and R4 are as listed in Table 1. Thus, compound 1 of Table 6 is the same as compound 1 of Table 1 except that in compound 1 of Table 6, the compound has the general foR""ula (IB). Similarly, compounds 2 to 662 of Table 6 are the same as compounds 2 to 662 of Table 1 except that in the compounds of Table 6, the compounds have the general foR""ula (IB). Table 7 Table 7 consists of 662 compounds of the general foR""ula (IB), where W, X and Z are N and Y is CH, R is CI, R1 is 2,5,6-trifIuorophenyl, and the values of R3 and R4 are as listed in Table 1. Thus, compound 1 of Table 7 is the same as compound 1 of Table 2 except that in compound 1 of Table 7, the compound has the general foR""ula (IB). Similarly, compounds 2 to 662 of Table 7 are the same as compounds 2 to 662 of Table 2 except that in the compounds of Table 7, the compounds have the general foR""ula (IB). Table 8 Table 8 consists of 662 compounds of the general foR""ula (IB), where W, X and Z are N and Y is CH, R is CI, R1 is 2,3,4,5,6-pentafluorophenyl, and the values of R3 and R4 are as listed in Table 3. Thus, compound 1 of Table 8 is the same as compound 1 of Table 3 except that in compound 1 of Table 8, the compound has the general foR""ula (IB). Similarly, compounds 2 to 662 of Table 8 are the same as compounds 2 to 662 of Table 3 except that in the compounds of Table 8, the compounds have the general foR""ula (IB). Table 9 Table 9 consists of 662 compounds of the general foR""ula (IB), where W, X and Z are N and Y is CH, R is CI, Rl is 2,6-difluoro-4-methoxyphenyl, and the values of R3 and R4 are as listed in Table 1. Thus, compound 1 of Table 9 is the same as compound 1 of Table 4 except that in compound 1 of Table 9, the compound has the general foR""ula (IB). Similarly, compounds 2 to 662 of Table 9 are the same as compounds 2 to 662 of Table 4 except that in the compounds of Table 9, the compounds have the general foR""ula ttBV Table 10 Table 10 consists of 662 compounds of the general foR""ula (IB), where W, X and Z are N and Y is CH, R is CI, R1 is 2-fluoro-6-chlorophenyl, and the values of R3 and R4 are as listed in Table 1. Thus, compound 1 of Table 10 is the same as compound 1 of Table 5 except that in compound 1 of Table 10, the compound has the general foR""ula (IB). Similarly, compounds 2 to 662 of Table 10 are the same as compounds 2 to 662 of Table 5 except that in the compounds of Table 10, the compounds have the general foR""ula (IB). Table 11 Table 11 consists of 662 compounds of the general foR""ula (1 A), where W, Y and Z are N and X is CH, R is CI, R1 is 2,4,6-trifluorophenyh and the values of R3 and R4 are as listed in Table 1. Thus, compound 1 of Table 11 is the same as compound 1 of Table 1 except that in compound 1 of Table 11, the compound has the general foR""ula (1 A) where W, Y and Z are N and X is CH. Similarly, compounds 2 to 662 of Table 11 are the same as compounds 2 to 662 of Table 1 except that in the compounds of Table 11, the compounds have the general foR""ula (1 A) where W, Y and Z are N and X is CH. . Table 12 Table 12 consists of 662 compounds of the general foR""ula (1 A), where W, Y and Z-. are N and X is CH, R is CI, R1 is 2,5,6-trifluorophenyl, and the values of R3 and R4 are as listed in Table 1. Thus, compound 1 of Table 12 is the same as compound 1 of Table 2 except that in compound 1 of Table 12, the compound has the general foR""ula (1 A) where W, Y and Z are N and X is CH. Similarly, compounds 2 to 662 of Table 12 are the same as compounds 2 to 662 of Table 2 except that in the compounds of Table 12, the compounds have the general foR""ula (1 A) where W, Y and Z are N and X is CH. Table 13 Table 13 consists of 662 compounds of the general foR""ula (1 A), where W, Y and Z are N and X is CH, R is CI, R1 is 2,3,4,5,6-pentafluorophenyl, and the values of R3 and R4 are as listed in Table 1. Thus, compound 1 of Table 13 is the same as compound 1 of Table 3 except that in compound 1 of Table 13, the compound has the general foR""ula (1A) where W, Y and Z are N and X is CH. Similarly, compounds 2 to 662 of Table 13 are the same as compounds 2 to 662 of Table 3 except that in the compounds of Table 13, the compounds Table 14 Table 14 consists of 662 compounds of the general foR""ula (1 A), where W, Y and Z are N and X is CH, R is CI, R1 is 2,6-difluoro-4-methoxyphenyl, and the values of R3 and R4 are as listed in Table 1. Thus, compound 1 of Table 14 is the same as compound 1 of Table 4 except that in compound 1 of Table 14, the compound has the general foR""ula (1 A) where W, Y and Z are N and X is CH. Similarly, compounds 2 to 662 of Table 14 are the same as compounds 2 to 662 of Table 4 except that in the compounds of Table 14, the compounds have the general foR""ula (1A) where W, Y and Z are N and X is CH. Table 15 Table 15 consists of 662 compounds of the general foR""ula (1 A), where W, Y and Z are N and X is CH, R is CI, R1 is 2-fluoro-6-chlorophenyl, and the values of R3 and.R4 are as listed in Table 1. Thus, compound 1 of Table 15 is the same as compound 1 of Table 5 except that in compound 1 of Table 15, the compound has the general foR""ula (1A) where W, Y and Z are N and X is CH. Similarly, compounds 2 to 662 of Table 15 are the same as * compounds 2 to 662 of Table 5 except that in the compounds of Table 15, the compounds have the general foR""ula (1 A) where W, Y and Z are N and X is CH. Table 16 Table 16 consists of 662 compounds of the general foR""ula (IB), where W, Y and Z are N and X is CH, R is CI, R is 2,4,6-trifluorophenyl, and the values of R and R areas listed in Table 1. Thus, compound 1 of Table 16 is the same as compound 1 of Table 11 except that in compound 1 of Table 16, the compound has the general foR""ula (IB). Similarly, compounds 2 to 662 of Table 16 are the same as compounds 2 to 662 of Table 11 except that in the compounds of Table 16, the compounds have the general foR""ula (IB). Table 17 Table 17 consists of 662 compounds of the general foR""ula (IB), where W, Y and Z are N and X is CH, R is CI, R1 is 2,5,6-trifluorophenyl, and the values of R3 and R4 are as listed in Table 1. Thus, compound 1 of Table 17 is the same as compound 1 of Table 12 except that in compound 1 of Table 17, the compound has the general foR""ula (IB). Similarly, compounds 2 to 662 of Table 17 are the same as compounds 2 to 662 of Table 12 except that in the compounds of Table 17, the compounds have the general fonnula (IB). Table 18 Table 18 consists of 662 compounds of the general foR""ula (IB), where W, Y and Z are N and X is CH, R is CI, R is 2,3,4,5,6-pentafluorophenyl, and the values of R3 and R4 are as listed in Table 1. Thus, compound I of Table IS is the same as compound 1 of Table 13 except that in compound 1 of Table 18: the compound has the general foR""ula (IB). Similarly, compounds 2 to 662 of Table IS are the same as compounds 2 to 662 of Table 13 except that in the compounds of Table IS, the compounds have the general foR""ula (IB). Table 19 Table 19 consists of 662 compounds of the general foR""ula (IB), where W, Y and Z 1 1 A are N and X is CH, R is CI, R is 2,6-difluoro-4-me:hoxyphenyl, and the values of R and R are as listed in Table 1. Thus, compound 1 of Table 19 is the same as compound 1 of Table 14 except that in compound 1 of Table 19, the compound has the general foR""ula (IB). Similarly, compounds 2 to 662 of Table 19 are the same as compounds 2 to 662 of Table 14 except that in the compounds of Table 19, the compounds have the general foR""ula (IB). Table 20 Table 20 consists of 662 compounds of the general foR""ula (IB), where W, Y and Z are N and X is CH, R is CI, R1 is 2-fluoro-6-chlorophenyl, and the values of R3 and R4 are as listed in Table 1. Thus, compound 1 of Table 20 is the same as compound 1 of Table 15 except that in compound 1 of Table 20, the compound has the general foR""ula (IB). Similarly, compounds 2 to 662 of Table 20 are the same as compounds 2 to 662 of Table 15 except that in the compounds of Table 20, the compounds have the general foR""ula (IB). Table 21 Table 21 consists of 662 compounds of the general foR""ula (1A), where W, X and Z are N and Y is CH, R is F, R1 is 2,4,6-trifluorophenyl, and the values of R3 and R4 are as listed in Table 1. Thus, compound 1 of Table 21 is the same as compound 1 of Table 1 except that in compound 1 of Table 21, R is F instead of CI. Similarly, compounds 2 to 662 of Table 21 are the same as compounds 2 to 662 of Table 1 except that in the compounds of Table 21, R is F instead of CI. Table 22 Table 22 consists of 662 compounds of the general foR""ula (1A), where W, X and Z are N and Y is CH, R is F, R1 is 2,5,6-trifluorophenyl, and the values of R3 and R4 are as listed in Table 1. Thus, compound 1 of Table 22 is the same as compound 1 of Table 2 except that in compound 1 of Table 22, R is F instead of CI. Similarly, compounds 2 to 662 of Table 22 are the same as compounds 2 to 662 of Table 2 except that in the compounds of Table 22, R is F instead of CI. Table 23 Table 23 consists of 662 compounds of the general foR""ula (1A), where W, X and Z are N and Y is CH, R is F, R1 is 2,3,4,5,6-pentafluorophenyl, and the values of R3 and R4 are as listed in Table 1. Thus, compound 1 of Table 23 is the same as compound 1 of Table 3 except that in compound 1 of Table 23, R is F instead of CI. Similarly, compounds 2 to 662 of Table 23 are the same as compounds 2 to 662 of Table 3 except that in the compounds of Table 23, R is F instead of CI. Table 24 Table 24 consists of 662 compounds of the general foR""ula (1A), where W, X and Z are N and Y is CH, R is F, R1 is 2,6-difluoro-4-methoxyphenyl, and the values of R" and R4 are as listed in Table 1. Thus, compound 1 of Table 24 is the same as compound 1 of Table 4 except that in compound 1 of Table 24, R is F instead of CI. Similarly, compounds 2 to 662 of Table 24 are the same as compounds 2 to 662 of Table 4 except that in the compounds of Table 24/R is F instead of CI. Table 25 Table 25 consists of 662 compounds of the general foR""ula (1 A), where W, X and Z are N and Y is CH, R is F, R! is 2-fluoro-6-chlorophenyl, and the values of R3 and R4 are as listed in Table 1. Thus, compound 1 of Table 25 is the same as compound 1 of Table 5 except that in compound 1 of Table 25, R is F instead of CI. Similarly, compounds 2 to 662 of Table 25 are the same as compounds 2 to 662 of Table 5 except that in the compounds of Table 25, R is F instead of CI. Table 26 Table 26 consists of 662 compounds of the general foR""ula (1A), where W, Y and Z are N and X is CH, R is F, R1 is 2,4,6-trifluorophenyl, and the values of R3 and R4 are as listed in Table 1. Thus, compound 1 of Table 26 is the same as compound 1 of Table 11 except that in compound 1 of Table 26, R is F instead of CI. Similarly, compounds 2 to 662 of Table 26 are the same as compounds 2 to 662 of Table 11 except that in the compounds of > Table 26, R is F instead of CI. Table 27 Table 27 consists of 662 compounds of the general foR""ula (1A), where W, Y and Z are N and X is CH, R is F, R is 2,5,6-trifluorophenyI, and the values of R3 and R4 are as listed in Table 1. Thus, compound 1 of Table 27 is the sambas compound 1 of Table 12 except that in compound 1 of Table 27, R is F instead of CI. Similarly, compounds 2 to 662 of Table 27 are the same as compounds 2 to 662 of Table 12 except that in the compounds of Table 27, R is F instead of CI. Table 28 Table 2S consists of 662 compounds of the general foR""ula (1 A), where W, Y and Z are N and X is CH, R is F, R1 is 2,3,4,5,6-pentafluorophenyl, and the values of R3 and R4 are as listed in Table I. Thus, compound 1 of Table 2S is the same as compound 1 of Table 13 except that in compound 1 of Table 28, R is F instead of CI. Similarly, compounds 2 to 662 of Table 2S are the same as compounds 2 to 662 of Table 13 except that in the compounds of Table 28, R is F instead of CI. Table 29 Table 29 consists of 662 compounds of the general foR""ula (1 A), where W, Y and Z are N and X is CH, R is F, R1 is 2,6-difluoro-4-methoxyphenyl, and the values of R3 and R4 are as listed in Table 1. Thus, compound 1 of Table 29 is the same as compound 1 of Table 14 except that in compound 1 of Table 29, R is F instead of CI. Similarly, compounds 2 to 662 of Table 29 are the same as compounds 2 to 662 of Table 14 except that in the compounds of Table 29, R is F instead of CI. Table 30 Table 30 consists of 662 compounds of the general foR""ula (1 A), where W, Y and Z are N and X is CH, R is F, R1 is 2-fluoro-6-chlorophenyI, and the values of R3 and R4 are as listed in Table 1. Thus, compound 1 of Table 30 is the same as compound 1 of Table 15 except that in compound 1 of Table 30, R is F instead of CI. Similarly, compounds 2 to 662 of Table 30 are the same as compounds 2 to 662 of Table 15 except that in the compounds of Table 30, R is F instead of CI. Table 31 Table 31 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 fo 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 31 R1 is 2,6-difluorophenyl instead of 2-fluoro-6-chlorophenyl. Table 32 Table 32 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same-as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 32 R1 is 2-fluorophenyl instead of 2-fluoro-6-chlorophenyl. Table 33 Table 33 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely/compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 33 R1 is 2,3,5,6-tetrafluorophenyl instead of 2-fluoro-6-chlorophenyl. Table 34 Table 34 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 34 R1 is 2-chloro-4,6-difluorophenyl instead of 2-fluoro-6-chlon> phenyl. Table 35 Table 35 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 35 R1 is 2-chlorophenyl instead of 2-fluoro-6-chlorophenyl. Table 36 Table 36 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 19S6 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as Compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 36 R1 is 2,6-dichlorophenyl instead of 2-fluoro-6-chlorophenyl. Table 37 Table 37 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 37 R1 is 2,4-dichlorophenyl instead of 2-fluoro-6-chlorophenyl. * Table 38 Table 38 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 38 R1 is 2,4,6-trichlorophenyl instead of 2-fluoro-6-chlorophenyI. Table 39 Table 39 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 39 R1 is 2,3,6-trichlorophenyl instead of 2-fluoro-6-chlorophenyl. Table 40 Table 40 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 40 R1 is pentachlorophenyl instead of 2-fluoro-6-chlorophenyl. Table 41 Table 41 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds-1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the Table 42 Table 42 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds" 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 42 R1 is 4-fluoro-2,6-dichlorophenyl instead of 2-fluoro-6-chloro-phenyl. Table 43 Table 43 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as ' compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds I to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the sameas compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 43 R1 is 2-bromophenyl instead of 2-fluoro-6-chlorophenyl. Table 44 Table 44 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 44 RJ is 2-fiuoro-6-bromophenyl instead of 2-fluoro-6-chlorophenyl. Table 45 Table 45 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the 5 compounds of Table 45 R1 is 2-bromo-4:6-difluorophenyl instead of 2-fluoro-6-chIoro-phenyl. Table 46 Table 46 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 264S are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely,-except that in all of the compounds of Table 46 R1 is 2-fluoro-6-methylphenyl instead of 2-fluoro-6-chlorophenyl. Table 47 Table 47 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds. 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 47 R is 2-chloro-6-methyIphenyl instead of 2-fluoro-6-chlorophenyl. Table 48 Table 48 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely,-compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 48 R1 is 2-methoxyphenyl instead of 2-fluoro-6-chlorophenyl. Table 49 Table 49 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 19S7 to 264S are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds I to 662 of Table 30 respectNely, except that in all of the compounds of Table 49 R1 is 2,6-dimethoxyphenyl instead of 2-fluoro-6-chlorophenyl. Table 50 Table 50 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds I to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 50 R1 is 2-fluoro-6-methoxyphenyl instead of 2-fhioro-6-chlorophenyl. Table 51 Table 51 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds I to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 51 R1 is 2-trifluoromethylphenyl instead of 2-fluoro-6-chlorophenyl. Table 52 compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 52 R1 is 2-fluoro-6-trifluoromethylphenyl instead of 2-fluoro-6-chIoro-phenyl. Table 53 Table 53 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 53 R1 is 2,6-di-(trifluoromethyI)phenyl instead of 2-fluoro-6-chloro-phenyl. Table 54 Table 54 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 54 R1 is 2-chloro-6-trifluoromethylphenyl instead of 2-fluoro-6-chlorophenyl. Table 55 Table 55 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 55 R1 is 2,4-ditluoro-6-trifluoromethylphenyl instead of 2-fIuoro-6-chlorophenyl. Table 56 Table 56 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 264S are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 56 R1 is 2,4-difluoro-6-methoxyphenyl instead of 2-fluoro-6-chloro-phenyl. Table 57 Table 57 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 57 R1 is 2,4-difIuoro-6-methylphenyl instead of 2-fluoro-6-chloro-phenyl. Table 58 Table 58 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 58 R1 is 2,4-difluoropyrid-3-yl instead of 2-fluoro-6-chlorophenyl. Table 59 Table 59 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 59 R1 is 3,5-difluoropyriC1-4-yl instead of 2-fluoro-6-chlorophenyl. Table 60 Table 60 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 19S6 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 60 Rl is tetrafluoropyriC1-4-yl instead of 2-fluoro-6-chlorophenyl. Table 61 Table 61 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the" compounds of Table 61 R1 is 3-fluoropyrid-2-yl instead of 2-fluoro-6-chlorophenyl. Table 62 compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 62 R1 is 4-fluoropyrid-3-yl instead of 2-fluoro-6-chlorophenyI. Table 63 Table 63 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 63 Rl is 3-fluoropyriC1-4-yl instead of 2-fluoro-6-chlorophenyl. Table. 64 Table 64 consistsof 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 1.5 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 64 R is 2-fluoropyrid-3-yl instead of 2-fluoro-6-chlorophenyl. Table 65 Table 65 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 65 R1 is 2,4,6-trifiuoropyrid-3-yl instead of 2-fIuoro-6-chlorophenyl. Table 66 Table 66 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 66 R1 is 3,5-difluoropyrid-2-yl instead of 2-fluoro-6-chlorophenyl. Table 67 -Table 67 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 19S7 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 331.1 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 67 R1 is 2,6-difluoropyrid-3-yl instead of 2-fluoro-6-chlorophenyl. Table 68 Table 68 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1-to 662 of Table 30 respectNely, except that in all of the compounds of Table 68 R1 is 2,4-difluoro-6-methoxypyrid-3-yI instead of 2-fluoro-6-chloro-phenyl. Table 69 Table 69 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 264S are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 69 R1 is 2-fluoro-4-chloropyrid-3-yI instead of 2-fluoro-6-chlorophenyl. Table 70 Table 70 consists of 3972 compounds. Compounds 1 to 6.62 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 19S7 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 70 R1 is 3-fluoro-5-chloropyriC1-4-yl instead of 2-fluoro-6-chlorophenyl. Table 71 Table 71 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 71 R1 is 2-chloro-4-fluoropyrid-3-yl instead of 2-fluoro-6-chlorophenyl. Table 72 Table 72 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 72 Rl is 2,4-dichloropyrid-3-yl instead of 2-fluoro-6-chlorophenyI. Table 73 Table 73 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 19S6 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 19S7 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 73 R1 is 3-chloropyrid-2-yl instead of 2-iluoro-6-chlorophenyl. Table 74 Table 74 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662"of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 74 R1 is 4-chloropyrid-3-yl instead of 2-fIuoro-6-chlorophenyl. Table 75 Table 75 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the Table 76 Table 76 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 19S7 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 76 R is 2-chloropyrid-3-yl instead of 2-fluoro-6-chlorophenyl. Table 77 Table 77 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to-662 of Table 15 respectNely, compounds 19S7to264S are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly *■*■ the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 77 R1 is 3-trifluoromethylpyrid-2-yl instead of 2-fluoro-6-chlorophenyL Table 7S Table 78 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 78 R1 is 4-trifluoromethylpyrid-3-yl instead of 2-fluoro-6-chlorophenyl - Table 79 Table 79 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 79 R1 is 3,5-dichloropyrid-2-yl instead of 2-fluoro-6-chlorophenyl. Table 80 Table 80 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 80 R1 is 4,6-dichloropyrid-3-yl instead of 2-fluoro-6-chlorophenyl. Table 81 Table 81 consists of 3972 compounds. Compounds-1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 81 R1 is 3-trifluoromethylpyriC1-4-yl instead of 2-fluoro-6-chlorophenyl. Table 82 Table 82 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the Table 83 Table S3 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 19S6 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 19S7 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table S3 R1 is 2-fluoro-4-trifIuoromethylpyrid'-3-yl instead of 2-fluoro-6-chlorophenyl. Table S4 Table 84 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are-exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 84 R1 is 3-fluoro-5-trifluoromethylpyriC1-4-yl instead of 2-fluoro-6-chlorophenyl. Table 85 Table 85 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 85 R1 is 4-fluoro-2-trifluoromethylpyrid-3-yl instead of 2-fluoro-6-chlorophenyl. Table S6 Table 86 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 19S7 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table S6 R] is 2,6-dichloropyrid-3-yl instead of 2-fluoro-6-chlorophenyl. Table 87 Table 87 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 87 R1 is 3,5-dichloropyriC1-4-yl instead of 2-fIuoro-6-chlorophenyl. Table 88 Table 88 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 19S6 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 88 R1 is 3-chloro-6-trifluoromethylpyrid-2-yl instead of 2-fluoro-6-chlorophenyl. Table S9 Table 89 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 89 R1 is 3-fluoro-6-trifluoromethylpyrid-2-yl instead of 2-fluoro-6-chlorophenyl. Table 90 Table 90 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 90 R! is pyrid-2-yl instead of 2-fluoro-6-chlorophenyl. Table 91 Table 91 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 91 R1 is pyrid-3-yl instead of 2-fluoro-6-chlorophenyl. Table 92 Table 92 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 92 R1 is pyriC1-4-yl instead of 2-fluoro-6-chlorophenyl. Table 93 Table 93 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 93 R1 is 3-fluorothien-2-yl instead of 2-fluoro-6-chlorophenyl. . Table 94 Table 94 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 3.0 respectNely, except that in all of the compounds of Table 94 R1 is 3-chlorothien-2-yl instead of 2-fluoro-6-chlorophenyl. Table 95 Table 95 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 95 R1 is 2,4-difluorothien-3-yl instead of 2-fluoro-6-chlorophenyl. Table 96 compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 96 R1 is 2,4-dichlorothien-3-yl instead of 2-fluoro-6-chlorophenyl. Table 97 Table 97 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1. to 662 of Table 30 respectNely, except that in all of the compounds of Table 97 R1 is 2,4,5-trichIorothien-3-yl instead of 2-fluoro-6-chlorophenyl. Table 98 Table 98 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 98 R1 is piperidino instead of 2-f]uoro-6-chlorophenyl. Table 99 Table 99 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds Lto 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 99 R1 is 2-methylpiperidino instead of 2-fluoro-6-chlorophenyl. Table 100 Table 100 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds T325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 264S are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 100 R is 2,6-dimethylpiperidino instead of 2-fluoro-6-chlorophenyl. Table 101 Table 101 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 2648 are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 101 R1 is morpholino instead of 2-fluoro-6-chlorophenyl. Table 102 Table 102 consists of 3972 compounds. Compounds 1 to 662 are exactly the same as compounds 1 to 662 of Table 5 respectNely, compounds 663 to 1324 are exactly the same as compounds 1 to 662 of Table 10 respectNely, compounds 1325 to 1986 are exactly the same as compounds 1 to 662 of Table 15 respectNely, compounds 1987 to 264S are exactly the same as compounds 1 to 662 of Table 20 respectNely, compounds 2649 to 3310 are exactly the same as compounds 1 to 662 of Table 25 respectNely, and compounds 3311 to 3972 are exactly the same as compounds 1 to 662 of Table 30 respectNely, except that in all of the compounds of Table 102 R1 is 2,6-dimethylmorpholino instead of 2-fIuoro-6-chlorophenyl. Table 103 Table 103 is the same as compound 1 of Table 1, compound 663 of Table 103 is the same as compound 1 of Table 2, compound 19,861 of Table 103 is the same as compound 1 of Table 31, compound 305,844 of Table 103 is the same as compound 3,972 of Table 102) except that in all of the compounds of Table 103 R is ethyl instead of CI or F. Table 104 Table 104 consists of 305,844 compounds. Each of these compounds is exactly the same as the corresponding compound in Tables 1 to 102 (thus, for example, compound 1 of Table 104 is the same as compound 1 of Table 1, compound 663 of Table 104 is the same as compound 1 of Table 2, compound 19,861 of Table 104 is the same as compound 1 of Table 31, compound 305,844 of Table 104 is the same as compound 3,972 of Table 102) except that in all of the compounds of TNle 104 R is Br instead of CI or F. Table 105 Table 105 consists of 305,844 compounds. Each of these compounds is exactly the same as the corresponding compound in Tables 1 to 102 (thus, for example, compound 1 "of Table 105 is the same as compound 1 of Table 1, compound 663 of Table 105 is the same as compound 1 of Table 2, compound 19,861 of Table 105 is the same as compound 1 of Table 31, compound 305,844 of Table 105 is the same as compound 3,972 of Table 102) except that in all of the compounds of Table 105 R is methyl instead of CI or F. Table 106 Table 106 consists of 305,844 compounds. Each of these compounds is exactly the same as the corresponding compound in Tables 1 to 102 (thus, for example, compound 1 of Table 106 is the same as compound 1 of Table 1, compound 663 of Table 106 is the same as compound 1 of Table 2, compound 19,861 of Table 106 is the same as compound 1 of Table 31, compound 305,844 of Table 106 is the same as compound 3,972 of Table 102) except that in all of the compounds of Table 106 R is H instead of CI or F. Table 107 Table 107 consists of 305,844 compounds. Each of these compounds is exactly the same as the corresponding compound in Tables 1 to 102 (thus, for example, compound 1 of Table 107 is the same as compound 1 of Table 1, compound 663 of Table 107 is the same as compound 1 of Table 2, compound 19,861 of Table 107 is the same as compound 1 of Table Table 108 . Table 108 consists of 305,844 compounds. Each of these compounds is exactly the same as the corresponding compound in Tables 1 to 102 (thus, for example, compound 1 of Table 10S is the same as compound 1 of Table 1, compound 663 of Table 108 is the same as compound 1 of Table 2, compound 19,861 of Table 108 is the same as compound 1 of Table 31; compound 305,844 of Table 10S is the same as compound 3,972 of Table 102) except that in all of the compounds of Table 108 R is methoxy instead of CI or F. Table 109 Table 109 consists of 6620 compounds. Each of these compounds is exactly the same as the corresponding compound in Tables 1 to 10 (thus, for example, compound 1 of Table 109 is the same as compound 1 of Table 1, compound 663 of Table 109 is the same as compound 1 of Table 2, etc.) except that in all of the compounds of Table 109 Y is CF instead of CH. Table 110 . Table 110 consists of 6620 compounds. Each of these compounds is exactly the same as the corresponding compound in Tables 1 to 10 (tfius, for example, compound 1 of Table 110 is the same as compound 1 of Table 1, compound 663 of Table 110 is the same as compound 1 of Table 2, etc.) except that in all of the compounds of Table 110 Y is CC1 instead of CH. Table 111 Table 111 consists of 6620 compounds. Each of these compounds is exactly the same as the corresponding compound in Tables 1 to 10 (thus, for example, compound 1 of Table 111 is the same as compound 1 of Table 1, compound 663 of Table 111 is the same as compound 1 of Table 2, etc.) except that in all of the compounds of Table 111 Y is CBr instead of CH. Table 112 Table 112 consists of 6620 compounds. Each of these compounds is exactly the same as thexorresponding compound in Tables 1 to 10 (thus, for example, compound 1 of Table 112 is the same as compound 1 of Table 1, compound 663 of Table 112 is the same as compound 1 of Table 2, etc.) except that in all of the compounds of Table 112 Y is CSCH3 Table 113 Table 113 consists of 6620 compounds. Each of these compounds is exactly the same as the corresponding compound in Tables 11 to 20 (thus, for example, compound 1 of Table 113 is the same as compound 1 of Table 11, compound 663 of Table 113 is the same as compound 1 of Table 12, etc.) except that in all of the compounds of Table 113 X is CF instead of CH. Table 114 Table 114 consists of 6620 compounds. Each of these compounds is exactly the same as the corresponding compound in Tables 11 to 20 (thus, for example, compound 1 of Table 114 is the same as compound 1 of Table 11, compound 663 of Table 114 is the same as compound 1 of Table 12, etc.) except that in all of the compounds of Table 114 X is CC1 - - instead of CH. Table 115 Table 115 consists of 6620 compounds. Each of these compounds is exactly the same as the corresponding compound in Tables 11 to 20 (thus, for example, compound 1 of Table 115 is the same as compound 1 of Table 11, compound 663 of Table 115 is the same as compound 1 of Table 12, etc.) except that in all of the compounds of Table 115 X is CBr instead of CH. Table 116 Table 116 consists of 6620 compounds. Each of these compounds is exactly the same as the corresponding compound in Tables 11 to 20 (thus, for example, compound I of Table 116 is the same as compound 1 of Table 11, compound 663 of Table 116 is the same as compound 1 of Table 12, etc.) except that in all of the compounds of Table 116 X is CSCH3 instead of CH. Table 117 Table 117 consists of 662 compounds of the general foR""ula (IB), where W, X and Z are N and Y is CH, R isF, R is 2,4,6-trifluorophenyl, and the values of R and R areas listed in Table 1. Thus, compound 1 of Table 117 is the same as compound 1 of Table 21 except that in compound 1 of Table 117, the compound has the general foR""ula (IB). Similarly, compounds 2 to 662 of Table 117 are the same as compounds 2 to 662 of Table 21 except that in the compounds of Table 117, the compounds have the general foR""ula (IB). Table 113 Table 1 IS consists of 662 compounds of the general foR""ula (IB where W, X and Z are N and V is CH, R is F, R1 is 2,5,6-trifluorophenyI, and the values of R3 and R4 are as listed in Table 1. Thus, compound 1 of Table 1 IS is the same as compound 1 of Table 22 except that in compound 1 of Table 118, the compound has the general foR""ula (IB). Similarly, compounds 2 to 662 of Table 1 IS are the same as compounds 2 to 662 of Table 22 except that in the compounds of Table 1 IS, the compounds have the general foR""ula (IB). Table 119 Table 119 consists of 662 compounds of the general foR""ula (IB), where W, X and Z - are N and V is CH, R is F, R1 is 2,3,4,576-pentafIuorophenyl, and the values of R3 and R4 are as listed in Table 1. Thus, compound 1 of Table 119 is the same as compound 1 of Table 23 except that in compound 1 of Table 119, the compound has the general foR""ula (IB). Similarly, compounds 2 to 662 of Table 119 are the same as compounds 2 to 662 of Table 23 except that in the compounds of Table 119, the compounds have the general foR""ula (IB). Table 120 Table 120 consists of 662 compounds of the general-foR""ula (IB), where W, X and Z 1 "3 A are N and Y is CH, R is F, R is 2,6-difluoro-4-methoxyphenyl, and the values of R and R are as listed in Table 1. Thus, compound 1 of Table 120 is the same as compound 1 of Table 24 except that in compound 1 of Table 120, the compound has the general foR""ula (IB). Similarly, compounds 2 to 662 of Table 120 are the same as compounds 2 to 662 of Table 24 except that in the compounds of Table 120, the compounds have the general foR""ula (IB). Table 121 Table 121 consists of 662 compounds of the general foR""ula (IB), where W, X and Z are N and Y is CH, R is F, R1 is 2-fIuoro-6-chlorophenyl, and the values of R3 and R4 are as listed in Table 1. Thus, compound 1 of Table 121 is the same as compound 1 of Table 25 except that in compound 1 of Table 121, the compound has the general foR""ula (IB). Similarly, compounds 2 to 662 of Table 121 are the same as compounds 2 to 662 of Table 25 except that in the compounds of Table 121, the compounds have the general foR""ula (IB). Table 122 Table 122 consists of 662 compounds of the general foR""ula (IB), where W, Y and Z are N and X is CH, RisF, R is 2,4,6-trifluorophenyl, and the values of R and R areas listed in Table 1. Thus, compound 1 except that in compound 1 of Table 122, the compound has the general foR""ula (IB). Similarly, compounds 2 to 662 of Table 122 are the same as compounds 2'to 662 of Table 26 except that in the compounds of Table 122, the compounds have the general foR""ula (IB). Table 123 Table 123 consists of 662 compounds of the general foR""ula (IB), where W, Y and Z are N and X is CH, R is F, R1 is 2,4,5-trifluorophenyl, and the values of R3 and R4 are as listed in Table 1. Thus, compound 1 of Table 123 is the same as compound 1 of Table 27 except that in compound 1 of Table 123, the compound has the general foR""ula (IB). Similarly, compounds 2 to 662 of Table 123 are the same as compounds 2 to 662 of Table 27 except that in the compounds of Table 123, the compounds have the general foR""ula (IB). Table 124 Table 124 consists of 662 compounds of the general foR""ula (IB), where W, Y and Z are N and X is CH, R is F, R is 2,3,4,5,6-pentafluorophenyl, and the values of R" and R are as listed in Table 1. Thus, compound 1 of Table 124 is the same as compound 1 of Table 28 except that in compound 1 of Table 124, the compound has the general foR""ula (IB). Similarly, compounds 2 to 662 of Table 124 are the same as compounds 2 to 662 of Table 28 except that in the compounds of Table 124, the compounds have the general foR""ula (IB). Table 125 Table* 125 consists of 662 compounds of the general foR""ula (IB), where W, Y and Z are N and X is CH, R is F, R1 is 2,6-difluoro-4-methoxyphenyl, and the values of R3 and R4 are as listed in Table 1. Thus, compound 1 of Table 125 is the same as compound 1 of Table 29 except that in compound 1 of Table 125, the compound has the general foR""ula (IB). Similarly, compounds 2 to 662 of Table 125 are the same as compounds 2 to 662 of Table 29 except that in the compounds of Table 125, the compounds have the general foR""ula (IB). Table 126 Table 126 consists of 662 compounds of the general foR""ula (IB), where W,Y and Z are N and X is CH, RisF, R is 2-fluoro-6-chlorophenyl, and the values of R and R areas listed in Table 1. Thus, compound 1 of Table 126 is the same as compound 1 of Table 30 except that in compound 1 of Table 126, the compound has the general foR""ula (IB). Similarly, compounds 2 to 662 of Table 126 are the same as compounds 2 to 662 of Table 30 except that in the compounds of Table 126, the compounds have the general foR""ula (IB). Table 127 Table 127 consists of 662 compounds of the general foR""ula (1A), where W, X and Z are N and Y is CH, R is NR3R4, R1 is 2,4,6-trifluorophenyI and the values of R3 and R4 are listed in Table 1. Thus, compound 1 of Table 127 is the same as compound 1 of Table 1 except that in compound 1 of Table 127, R is NR R . Similarly, compounds 2 to 662 of Table 127 are the same as compounds 2 io 662 of Table 1 except that in the compounds of Table 127, R is NR3R4. It should be noted that in each compound there are the two NR3R4 groups, both of which are the same. In other words R^ and R4 in the NR3R4 group shown in foR""ula (1A) and in the NR3R4 group that is R, have the same values. These are the values set out in Table 1. Table 128 Table 128 consists of 662 compounds of the general foR""ula (lA), where W, X and Z are N and Y is CH, R is NR3R4, R1 is 2-fluoro-6-chlorophenyI and the values of R3 and R4 are listed in Table 1. Thus, compound 1 of Table 128 is the same as compound 1 of Table 5 except that in compound 1 of Table 128, R is NR'R . Similarly, compounds 2 to 662 of Table 128 are the same as compounds 2 to 662 of Table 5 except that in the compounds of - Table 128, R is NR3R4. It should be noted that in each compound there are the two NR3R4 groups, both of which are the same. In other words R3 and R4 in the NR3R4 group shown in foR""ula (1 A) and in the NR3R4 group that is R, have the same values. These are the values set out in Table 1. Table 129 Table 129 consists of 662 compounds of the general foR""ula (1A), where W, Y and Z are N and X is CH, R is NR3R4, R1 is 2,4,6-trifluorophenyl and the values of R3 and R4 are listed in Table 1. Thus, compound 1 of Table 129 is the same as compound 1 of Table 1 except that in compound 1 of Table 129, R is NR3R4. Similarly, compounds 2 to 662 of Table 129 are the same as compounds 2 to 662 of Table 1 except that in the compounds of Table 129, R is NR3R4. It should be noted that in each compound there are the two NR3R4 groups, both of which are the same. In other words R3 and R4 in the NR3R4 group shown in foR""ula (1A) and in the NR3R group that is R, have the same values. These are the values set out in Table 1. Table 130 Table 130 consists of 662 compounds of the general foR""ula (1 A), where W, Y and Z are N and X is CH, R is NR3R4, R! is 2-fluoro-6-chlorophenyl and the values of R3 and R4 Table 130 are the same as compounds 2 to 662 of Table 5 except that in the compounds of Table 130, R is NR3R4. It should be noted that in each compound there are the two NR3R4 groups, both of which are the same. In other words R and R in the NR-R group shown in foR""ula (1 A) and in the NR3R4 group that is R, have the same values. These are the values set out in Table 1. Compounds of foR""ula (7) or (8), which are examples of compounds of general foR""ula (1) where one of R and R is NR R , can be made as shown in Scheme 1, in which W, X, Y, Z, R1, R and R4 have the meanings gNen above and R7 is C1-4 alkyl. Compounds of general foR""ula (4) can be prepared from compounds of general foR""ula (2), which are either commercially available or made by methods known in the literature, by reaction with acids of general foR""ula (3), using standard coupling methods, for example by conversion to the acid chloride using a chlorinating agent such as thionyl chloride, followed by reaction of the resultant acid chloride optionally in the presence of a base such as triethylamine, in a suitable solvent such as dichloromethane or toluene. foR""ula (4) with a base such as sodium hydride, optionally in the presence of a Lewis acid such as magnesium oxide, in a suitable solvent such as AOV-dimethylfoR""amide (DMF)'or toluene, at between room temperature and 150°C, but preferably at 60-90°C. Compounds of general foR""ula (6) can be prepared by reaction of compounds of general foR""ula (5) with a chlorination reagent such as phosphorus oxychloride, either neat or in a suitable solvent such as toluene, at between 50 and 150°C, but preferably between 80 and 110°C or in a microwave reactor at between 150 and 300°C, but preferably between 200 and 250°C. Compounds of foR""ula (7) and (8) can be prepared by reaction of compounds of general - foR""ula (6) with an amine R3R4NH, either neat, or in a suitable solvent such as DMF, between room temperature and 150°C, but preferably between 50 and 80°C If compounds (7) and (8) are produced as a mixture they can be separated by suitable means such as crystallisation or chromatography under noR""al or reverse phase conditions. Compounds of the general foR""ulae (5), (6), (7) and (8) may be derNatised, via the chloro or hydroxy substituents, using routine chemical techniques to foR"" other compounds of the general foR""ula (1). AlternatNely, other compounds of the general foR""ula (1) may be prepared using a similar methodology to that described for preparing the compounds (5) to (8) and employing preparatNe techniques known from the chemical literature. Compounds of foR""ula (7) can also be made as shown in scheme 2. Compounds of general foR""ula (10) can be prepared from compounds of general foR""ula (9), which are either commercially available or made by methods known in the literature, by reaction with acids of general foR""ula (3), using standard coupling methods, for example by conversion to the acid chloride using a chlorinating agent such as thionyl chloride, followed by reaction of the resultant acid chloride optionally in the presence of a base such as triethylamine, in a suitable solvent such as dichloromethane or toluene. Compounds of general foR""ula (11) can be prepared by treating compounds of general foR""ula (10) with a base such as sodium hydride, optionally in the presence of a Lewis acid such as magnesium oxide, in a suitable solvent sucJi\s NV-dimethylfoR""arnide (DMF) or toluene, at between room temperature and 150°C, but preferably at 60-90°C. Compounds of general foR""ula (12) can be prepared by reaction of compounds of general foR""ula (11) with a chlorination reagent such as phosphorus oxychloride, either neat or in a suitable solvent such as toluene, at between 50 and 150°C, but preferably between 80 and 110°C, or in a microwave reactor at between 150 and 300°C, but preferably between 200 and 250°C. Compounds of foR""ula (7) can be prepared from compounds of foR""ula (12) by reductNe amination, for example by reaction with a ketone or aldehyde in a suitable solvent such as ethanol or toluene, at between room temperature and reflux, optionally in the presence of an acid catalyst such as para-toluenesulphonic acid or a drying agent such as molecular sieves, followed by treatment with a suitable reducing agent such as sodium borohydride, at between -20°C and 40°C, but preferably at room temperature. The aldehyde or ketone is chosen so that the desired groups R and R are foR""ed after reduction of the product of reaction with the amine (12). For example if compounds of foR""ula (12) are reacted with one equNalent of propionaldehyde and then sodium borohydride, compounds of foR""ula (7) where R3 is n-propyl, and R is hydrogen are foR""ed. If required, the reaction can be repeated with a different aldehyde or ketone. For example, if acetone is used for the second reaction, then compounds of foR""ula (7) where R3 is /z-propyl and R4 is /50-propyl, are foR""ed. AlternatNely compounds of foR""ula (7) can be foR""ed from compounds of foR""ula (12) by alkylation with a'group R LG, where LG is a leaving group, by treatment with a suitable base such as sodium hydride in a solvent such as DMF, or a base such as potassium carbonate in a solvent such as acetone or DMF, at between -78°C and 100°C, but preferably between room temperature and 60°C, followed by treatment with R4LG in a second step under conditions if required. Compounds of foR""ula (13) can be prepared as shown in Scheme 3 from compounds of foR""ula (6) by reaction with a source of fluoride ion, such as potassium fluoride, in a suitable solvent such as sulpholane, at a temperature between 50°C and 200°C, but preferably at S0-150°C. Compounds of foR""ula (14) and/or compounds of foR""ula (15) can be prepared from difluoro compounds of foR""ula (13) by reaction with an amine of foR""ula R3R4NH in a suitable solvent such as DMF or CH2CI2, at a temperature of 0°C-100°C, but preferably at room temperature. Compounds of general foR""ula (16), where Hal1 is chlorine or fluorine, can be converted into compounds of foR""ula (17), (18), (19), (20), (21), (22) or (23) as shown in Scheme 4. Compounds of general foR""ula (17) where Hal" is bromine or iodine can be foR""ed by reacting compounds of general foR""ula (16) with a metal halide, for example cuprous bromide, in a suitable solvent, for example DMF, at between room temperature and 155°C, but preferably between 70°C and 155°C. Compounds of general foR""ula (18) where V is oxygen or sulphur and R9 is C1-3 alkyl, can be foR""ed by reacting compounds of general foR""ula (16) with a metal alkoxide or thioalkoxide MVR9 in a suitable solvent, for example sodium methoxide in methanol, at room temperature to 65°C. Compounds of general foR""ula (19) can be foR""ed by reacting compounds of generaj foR""ula (16) with a metal cyanide in a suitable solvent, for example cuprous cyanide in DMF, at between room temperature and 155°C but preferably between 50°C and 155°C. Compounds of general foR""ula (20) where Ri0 is C1-8 alkyl, can be foR""ed by reacting compounds of general foR""ula (16) with an alkyl metal derNatNe in a suitable solvent, for example methyl magnesium bromide in THF, optionally in the presence of catalyst such as cuprous bromide or Pd(Ph)4, between -40°C and 50°C. Compounds of general foR""ula (21) can be foR""ed by reduction of compounds of general foR""ula (16), where Hal1 is chlorine, for example by hydrogenolysis with hydrogen gas and a metal catalyst such as palladium on carbon in a suitable solvent such as ethanol, at room temperature. Compounds of general foR""ula (22) where R is hydrogen or C1-6 alkyl, can be foR""ed by reaction of compounds of general foR""ula (16) with an alkyl acetylene under the Sonogashira conditions, for example with 1-propyne in triethylamine in the presence of a cuprous salt such as cuprous iodide and a palladium catalyst such as Pd(Ph)4, between room temperature and 70°C. Compounds of general foR""ula (23) where R12 is hydrogen or C1-4 alkyl, can be foR""ed by reaction of compounds of general foR""ula (16) with an alkenyl metal derNatNe in a suitable solvent, such as ethenylboronic acid in THF, in the presence of a palladium catalyst such as Pd(Ph)4 and a base such as caesium carbonate, between room temperature and 65°C. In Scheme 6, compounds of general foR""ula (25), which are useful for preparation as shown in Scheme 1 of compounds of foR""ula (1) where W, X and Z are N and Y is CH, can be prepared by reduction of compounds of foR""ula (24), which are known in the literature, using for example Raney Nickel in a suitable solvent such as ethanol, at between room temperature and reflux. In Scheme 7, compounds of general foR""ula (28) which are useful for the preparation, as shown in Scheme 1, of compounds of foR""ula (1) where W, X and Z are N and Y is CH, can be prepared by reduction of compounds of foR""ula (26) where n is 0,1 or 2, which can prepared from compounds of foR""ula (24) as shown in Scheme 1, using for example Raney Nickel in a suitable solvent, such as ethanol, at between room temperature and reflux. AlternatNely, compounds of general foR""ula (26) can be converted into hydrazino compounds of general foR""ula (27), with hydrazine hydrate in a suitable solvent such as methanol, between room temperature and reflux. Compounds of foR""ula (27) are then treated with an oxidising agent, such as copper sulphate or mercuric oxide, in a suitable solvent such as aqueous ethanol, between room temperature and reflux, to gNe compounds of foR""ula (28). Further assistance in the preparation of the compounds of foR""ula (1) may be derNed from the following publications: Emilio, Toja, et. al, J. Heterocyclic Che,n.y 23, 1955 (1986), H. Schafer, et at, J.f.prakt. Chemie, 321(4), 695 (1970) and H. Bredereck et a/„ Chem. Ber. 96,1868-1872 (1993). The inteR""ediate chemicals having the general foR""ulae (4), (5), (6) and (13): 1 7 wherein W, X, Y, Z, R and R are as define above, arc believed to be novel compounds and foR"" a further part of this invention. It should be noted that the inteR""ediate of general foR""ula (5) may exist in the 5 tautomeric foR""s (a), (b) and (c) as well as in the foR"" shown in foR""ula (5): The invention as defined by the general foR""ula (5) embraces all such tautomers. Of particular interest are the inteR""ediates listed in Tables 131 to 135 below. In Table 131 the compounds have the general foR""ula (4) where R7 is methyl and W, X, Y, Z and R1 ) have the values shown in the table. i Table 132 Table 132 consists of 25 compounds of the general foR""ula (5), where W, X, Y, Z and R1 have the values gNen in Table 131. Thus, compound 1 of Table 132 has the same W, X, Y, Z and R1 values as compound 1 of Table 131, etc. Table 133 Table 133 consists of 25 compounds of the general foR""ula (6), where W, X, Y, Z and R1 have the values gNen in Table 131. Thus, compound 1 of Table 133 has the same W, X, Y, Z and R1 values as compound 1 of Table 131, etc. Table 134 Table 134 consists of 25 compounds of the general foR""ula (13), where W, X, Y, Z and R1 have the values gNen in Table 131. Thus, compound 1 of Table 134 has the same W, X, Y, Z and R1 values as compound 1 of Table 131, etc. Table 135 Table 135 consists of 25 compounds of the general foR""ula (4), where W, X, Y, Z and R have the values gNen in Table 131 and R is ethyl. Thus, compound 1 of Table 135 is the same as compound 1 of Table 131 except that in compound 1 of Table 135, R7 is ethyl instead of methyl. Similarly, compounds 2 to 24 of Table 135 are the same as compounds 2 to 24 of Table 131 except that in the compounds of Table 135, R7 is ethyl. The compounds of foR""ula (1) are actNe fungicides and may be used to control one or more of the following pathogens: Pyriculana oiyzae (Magnaporthe grisea) on rice and wheat and other Pyricularia spp. on other hosts; Puccinia triticina (or recondita), Puccinia striifoR""is and other rusts on wheat, Puccinia hordei, Puccinia striifoR""is and other rusts on barley, and rusts on other hosts (for example turf, rye, coffee, pears, apples, peanuts, sugar beet, vegetables and ornamental plants); £,ysiphe cichoracearum on cucurbits (for example melon); Blumeria (or Eiysiphe) gra/ninis (powdery mildew) on barley, wheat, rye and turf and other powdery mildews on various hosts, such as Sphaerotheca macularis on hops, Sphaerotheca fusca (Sphaerotheca fuliginea) on cucurbits (for example cucumber), Leveillula taurica on tomatoes, aubergine and green pepper, Podosphaera leucotricha on apples and Uncinxda necatoron vines; Cochliobolus spp., Helminthosporium spp., Drechslera spp. (Pyrenophora spp.), Rhynchosporium spp., Mycosphaerella graminicola (Septoria tritici) and Phaeosphaeria nodorum (Stagonospora nodorwn or Septoria nodonun), Pseudocercosporella herpotrichoides and Gaeumannomyces graminis on cereals (for example wheat, barley, rye), turf and other hosts; Cercospora arachidicola and Cercosporidium personatum on peanuts and other Cercospora spp. on other hosts, for example sugar beet, bananas, soya beans and rice; Botiytis cinerea (grey mould) on tomatoes, strawberries, vegetables, vines and other hosts and other Botiytis spp. on other hosts; Alternaria spp. on vegetables (for example carrots), oil-seed rape, apples, tomatoes, potatoes, cereals (for example wheat) and other hosts; Venturia spp. (including Ventnria inaequalis (scab)) on apples, pears, stone fruit, tree nuts and other hosts; Cladosporium spp. on a range of hosts including cereals (for example wheat) and tomatoes; Monilinia spp. on stone fruit, tree nuts and other hosts; Didymella spp. on tomatoes, turf, wheat, cucurbits and other hosts; Phoma spp. on oil-seed rape, turf, rice, potatoes, wheat and other hosts; Aspergillus spp. and Aureobasidiwn spp. on wheat, lumber and other hosts; Ascochyta spp. on peas, wheat, barley and other hosts; Stemphyliam spp. (Pleospora spp.) on apples, pears, onions and other hosts; summer diseases (for example bitter rot (Glomerella cingidata), black rot or frogeye leaf spot (Botryosphaeria obtusa)y Brooks fruit spot (Mycosphaerella porni), Cedar apple rust (Gymnosporangium juniperi-virginianae), sooty Giocodes pomigena), flyspeck (Schizothyrium pomi) and white rot (Botryosphaeria dothidea)) on apples and pears; Plasmopara viticola on vines; other downy mildews, such as Brernia lactucae on lettuce, Peronospora spp. on soybeans, tobacco, onions and other hosts, Pseudoperonospora humuli on hops and Pseudoperonospora cubensis on cucurbits; Pythium spp. (including Pvthium ultimum) on turf and other hosts; Phytophthora infestans on potatoes and tomatoes and other Phytophthora spp. on vegetables, strawberries, avocado, pepper, ornamentals, tobacco, cocoa and other hosts; Thanatephorus cucumeris on rice and turf and other Rhizoctonia spp. on various hosts such as wheat and barley, peanuts, vegetables, cotton and turf; Sclerotinia spp. on turf, peanuts, potatoes, oil-seed rape and other hosts; Sclerotiwn spp. on turf, peanuts and other hosts; Gibberella fitjikuroi on rice; Colletotrichum spp. on a range of hosts including turf, coffee and vegetables; Laetisaria facifoR""is on turf; Mycosphaerella spp. on bananas, peanuts, citrus, .pecans, papaya and other hosts; Diaporthe spp. on citrus, soybean, melon, pears, lupin and other hosts; Elsinoe spp. on citrus, vines, olNes, pecans, roses and other hosts; Verticillium spp. on a range of hosts including hops, potatoes and tomatoes; Pyrenopeziza spp. on oil-seed rape and other hosts; Oncobasidiam theobromde on cocoa causing vascular streak dieback; Fusarium spp., Typhula spp., Microdochium nNale, Ustilago spp., Urocystis spp., Tilletia spp. and Claviceps purpurea on a variety of hosts but particularly wheat, barley, turf and maize; Ramularia spp. on sugar beet, barley and other hosts; post-harvest diseases particularly of fruit (for example Pemcillium digitatwn, Penicillium italicwn and TrichodeR""a viride on oranges, Colletotrichum musae and Gloeosporium musarum on bananas and Botiytis cinerea on grapes); other pathogens on vines, notably Eutypa lata, Guignardia bidwellii, Phellinus igniams, Phomopsis viticola, Pseudopeziza tracheiphila and Steream hirsutum,other pathogens on trees (for example LophodeR""ium seditiosuni) or lumber, notably Cephaloascus fragrans, Ceratocystis spp., Ophiostomapiceae, Penicillium spp., TrichodeR""a pseudokoningii, TrichodeR""a viride, TrichodeR""a harziamon, Aspergillus niger, Leptographium lindbergi and Aureobasidium pullulans; and fungal vectors of viral diseases (for example Polymyxa graminis on cereals as the vector of barley yellow mosaic virus (BYMV) and Polymyxa betae on sugar beet as the vector of rhizomania). A compound of foR""ula (1) may move acropetally, basipetally or locally in plant tissue to be actNe against one or more fungi. Moreover, a compound of foR""ula (1) may be volatile enough to be actNe in the vapour phase against one or more fungi on the plant. The invention therefore provides a method of combating or controlling phytopatho-genic fungi which comprises applying a fungicidally effectNe amount of a compound of foR""ula (1), or a composition containing a compound of foR""ula (1), to a plant, to a seed of a plant, to the locus of the plant or seed or to soil or any other plant growth medium, e.g. nutrient solution. The teR"" '"plant'1 as used herein includes seedlings, bushes and trees. FurtheR""ore, the fungicidal method of the invention includes protectant, curatNe, systemic, eradicant and antisporulant treatments. The compounds of foR""ula (1) are preferably used for agricultural, horticultural and turfgrass purposes in the foR"" of a composition. In order to apply a compound of foR""ula (1) to a plant, to a seed of a plant, to the locus of the plant or seed or to soil or any other growth medium, a compound of foR""ula (1) is usually foR""ulated into a composition which includes, in addition to the compound of foR""ula (1), a suitable inert diluent or carrier and, optionally, a surface actNe agent (SFA). SFAs are chemicals that are able to modify the properties of an interface (for example, liquid/solid, liquid/air or liquid/liquid interfaces) by lowering the interfacial tension and thereby leading to changes in other properties (for example dispersion, emulsification and wetting). It is preferred that all compositions (both solid and liquid foR""ulations) comprise, by weight, 0.0001 to 95%, more preferably 1 to 85%, for example 5 to 60%, of a compound of foR""ula (1). The composition is generally used for the control of fungi such that a compound of foR""ula (1) is applied at a rate of from O.lg to 10kg per hectare, preferably from lg to 6kg per hectare, more preferably from lg to 1kg per hectare. When used in a seed dressing, a compound of foR""ula (1) is used at a rate of 0.000 lg to lOg (for example 0.00lg or 0.05g), preferably 0.005g to lOg, more preferably 0.005g to 4g, per kilogram of seed. In another aspect the present invention provides a fungicidal composition comprising a fungicidally effectNe amount of a compound of foR""ula (1) and a suitable carrier or diluent therefor. In a still further aspect the invention provides a method of combating and controlling fungi at a locus, which comprises treating the fungi, or the locus of the fungi with a fungicidally effectNe amount of acorn: The compositions can be chosen from a number of foR""ulation types, including dustable powders (DP), soluble powders (SP), water soluble granules (SG), water dispersible granules (WG), wettable powders (WP), granules (GR) (slow or fast release), soluble concentrates (SL), oil miscible liquids (OL), ultra low volume liquids (UL), emulsifiable concentrates (EC), dispersible concentrates (DC), emulsions (both oil in water (E\V) and water in oil (EO)), micro-emulsions (ME), suspension concentrates (SC), aerosols, fogging/smoke foR""ulations, capsule suspensions (CS) and seed treatment foR""ulations. The foR""ulation type chosen in any instance will depend upon the particular purpose envisaged and the physical; chemical and biological properties of the compound of foR""ula (1). Dustable powders (DP) may be prepared by mixing a compound of foR""ula (1) with one or more solid diluents (for example natural clays, kaolin, pyrophyllite, bentonite, alumina, montmorillonite, kieselguhr, chalk, diatomaceous earths, calcium phosphates, calcium and magnesium carbonates, sulphur, lime, flours, talc and other organic and inorganic solid carriers) and mechanically grinding the mixture to a fine powder. Soluble powders (SP) may be prepared by mixing a compound of foR""ula (1) with one or more water-soluble inorganic salts (such as sodium bicarbonate, sodium carbonate or magnesium sulphate) or one or more water-soluble organic solids (such as a polysaccharide) and, optionally, one or more wetting agents, one or more dispersing agents or a mixture of said agents to improve water dispersibility/solubility. The mixture is then ground to a fine powder. Similar compositions may also be granulated to foR"" water soluble granules (SG). Wettable powders (WP) may be prepared by mixing a compound of foR""ula (1) with one or more solid diluents or carriers, one or more wetting agents and, preferably, one or more dispersing agents and, optionally, one or more suspending agents to facilitate the dispersion in liquids. The mixture is then ground to a fine powder. Similar compositions may also be granulated to foR"" water dispersible granules (WG). Granules (GR) may be foR""ed either by granulating a mixture of a compound of foR""ula (1) and one or more powdered solid diluents or carriers, or from pre-foR""ed blank granules by absorbing a compound of foR""ula (1) (or a solution thereof, in a suitable agent) in a porous granular material (such as pumice, attapulgite clays, fuller's earth, kieselguhr, diatomaceous earths or ground corn cobs) or by adsorbing a compound of foR""ula (1) (or a solution thereof, in a suitable agent) on to a hard core material (such as sands, silicates, mineral carbonates, sulphates or phosphates) and drying if necessary. Agents which are commonly used to aid absorption or adsorption include solvents (such as aliphatic and aromatic petroleum solvents, alcohols, ethers, ketones and esters) and sticking agents (such as polyvinyl acetates, polyvinyl alcohols, dextrins, sugars and vegetable oils). One or more other additNes may also be included in granules (for example an emulsifying agent, wetting agent or dispersing agent). Dispersible Concentrates (DC) may be prepared by dissolving a compound of foR""ula (1) in water or an organic solvent, such as a ketone, alcohol or glycol ether. These solutions may contain a surface actNe agent (for example to improve water dilution or prevent crystallisation in a spray tank). Emulsifiable concentrates (EC) or oil-in-water emulsions (EW) may be prepared by dissolving a compound of foR""ula (1) in an organic solvent (optionally containing one or more wetting agents, one or more emulsifying agents or a mixture of said agents). Suitable organic solvents for use in ECs include aromatic hydrocarbons (such as alkylbenzenes or alkylnaphthalenes, exemplified by SOLVESSO 100, SOLVESSO 150 and SOLVESSO 200; SOLVESSO is a Registered Trade Mark), ketones (such as cyclohexanone or methylcyclo-hexanone); alcohols (such as benzyl alcohol, furfuryl alcohol or butanol), Af-alkylpyr-rolidones (such as Af-rnethylpyrrolidone or TV-octylpyrrolidone), dimethyl amides of fatty acids (such as Cg-Cio fatty acid diethylamide) and chlorinated hydrocarbons. An EC product may spontaneously emulsify on addition to water, to produce an emulsion with sufficient stability to allow spray application through appropriate equipment. Preparation of an EW involves obtaining a compound of foR""ula (1) either as a liquid (if it is not a liquid at room temperature, it may be melted at a reasonable temperature, typically below 70°C) or in solution (by dissolving it in an appropriate solvent) and then emulsifying the resultant liquid or solution into water containing one or more SFAs, under high shear, to produce an emulsion. Suitable solvents for use in EWs include vegetable oils, chlorinated hydrocarbons (such as chlorobenzenes), aromatic solvents (such as alkylbenzenes or alkylnaphthalenes) and other appropriate organic solvents that have a low solubility in water. Microemulsions (ME) may be prepared by mixing water with a blend of one or more solvents with one or more SFAs, to produce spontaneously a theR""odynamically stable isotropic liquid foR""ulation. A compound of foR""ula (1) is present initially in either the system (which system is present may be deteR""ined by conductNity measurements) and may be suitable for mixing water-soluble and oil-soluble pesticides in the same foR""ulation. An ME is suitable for dilution into water, either remaining as a microemulsion or foR""ing a conventional oil-in-water emulsion. Suspension concentrates (SC) may comprise aqueous or non-aqueous suspensions of finely dNided insoluble solid particles of a compound of foR""ula (1). SCs may be prepared by ball or bead milling the solid compound of foR""ula (1) in a suitable medium, optionally with one or more dispersing agents, to produce a fine particle suspension of the compound. One or more wetting agents may be included in the composition and a suspending agent may be included to reduce the rate at which the particles settle. AlternatNely, a compound of foR""ula (1) may be dry milled and added to water, containing agents hereinbefore described, to produce the desired end product. Aerosol foR""ulations comprise a compound of foR""ula (1) and a suitable propellant (for example /7-butane). A compound of foR""ula (1) may also be dissolved or dispersed in a suitable medium (for example water or a water miscible liquid, such as /7-propanol) to provide compositions for use in non-pressurised, hand-actuated spray pumps. A compound of foR""ula (1) may be mixed in" the dry state with a pyrotechnic mixture to foR"" a composition suitable for generating, in an enclosed space, a smoke containing the compound. Capsule suspensions (CS) may be prepared in a manner similar to the preparation of EW foR""ulations but with an additional polymerisation stage such that an aqueous dispersion of oil droplets is obtained, in which each oil droplet is encapsulated by a polymeric shell and contains a compound of foR""ula (1) and, optionally, a carrier or diluent therefor. The polymeric shell may be produced by either an interfacial polycondensation reaction or by a coacervation procedure. The compositions may provide for controlled release of the compound of foR""ula (1) and they may be used for seed treatment. A compound of foR""ula (1) may also be foR""ulated in a biodegradable polymeric matrix to provide a slow, controlled release of the compound. A composition may include one or more additNes to improve the biological perfoR""ance of the composition (for example by improving wetting, retention or distribution on surfaces; resistance to rain on treated surfaces; or uptake or mobility of a compound of foR""ula (1)). Such additNes include surface actNeagents, spray adliifNes based on oils, for example certain mineral oils or natural plant oils (such as soybean and rape seed oil), and blends of these with other bio-enhancing adjuvants (ingredients which may aid or modify the action of a compound of foR""ula (1)). A compound of foR""ula (1) may also be foR""ulated for use as a seed treatment, for example as a powder composition, including a powder for dry seed treatment (DS), a water soluble powder (SS) or a water dispersible powder for slurry treatment (WS), or as a liquid composition, including a flowable concentrate (FS), a solution (LS) or a capsule suspension (CS). The preparations of DS, SS, WS, FS and LS compositions are very similar to those of, respectNely, DP, SP, WP, SC and DC compositions described above. Compositions for treating seed may include an agent for assisting the adhesion of the composition to the seed (for example a mineral oil or a film-foR""ing barrier). Wetting agents, dispersing agents and emulsifying agents may be SFAs of the cationic, anionic, amphoteric or non-iorfic type. Suitable SFAs of the cationic type include quaternary ammonium compounds (for example cetyltrimethyl ammonium bromide), imidazolines and amine salts. Suitable anionic SFAs include alkali metals salts of fatty acids, salts of aliphatic monoesters of sulphuric acid (for example sodium lauryl sulphate), salts of sulphonated aromatic compounds (for example sodium dodecylbenzenesulphonate, calcium dodecylbenzenesulphonate, butylnaphthalene sulphonate and mixtures of sodium di-wopropyl- and tri-zsopropyl-naphthalene sulphonates), ether sulphates, alcohol ether sulphates (for example sodium laureth-3-sulphate), ether carboxylates (for example sodium laureth-3-carboxylate), phosphate esters (products from, the reaction between one or more fatty alcohols and phosphoric acid (predominately mono-esters) or phosphorus pentoxide (predominately di-esters), for example the reaction between lauryl alcohol and tetraphosphoric acid; additionally these products may be ethoxylated), sulphosuccinamates, paraffin or olefine sulphonates, taurates and lignosulphonates. Suitable SFAs of the amphoteric type include betaines, propionates and glycinates. Suitable SFAs of the non-ionic type include condensation products of alkylene oxides, such as ethylene oxide, propylene oxide, butylene oxide or mixtures thereof, with fatty alcohols (such as oleyl alcohol orcetyl alcohol) or with alkylphenols (such as octylphenol, (comprising ethylene oxide and propylene oxide); alkanolamides; simple esters (for example fatty acid polyethylene glycol esters); amine oxides (for example lauryl dimethyl amine oxide); and lecithins-Suitable suspending agents include hydrophilic colloids (such as polysaccharides, polyvinylpyrrolidone or sodium carboxymethylcellulose) and swelling clays (such as bentonite or attapulgite). A compound of foR""ula (1) may be applied by any of the known means of applying fungicidal compounds. For example, it maybe applied, foR""ulated or unfoR""ulated, to any part of the plant, including the foliage, stems, branches or roots, to the seed before it is § planted or to other media in which plants are growing or are to be planted (such as soil surrounding the roots, the soil generally, paddy water or hydroponic culture systems), difectly or it may be sprayed on, dusted on, applied by dipping, applied as a cream or paste foR""ulation, applied as a vapour or applied through distribution or incorporation of a composition (such as a granular composition or a composition packed in a water-soluble bag) in soil or an aqueous environment, A compound of foR""ula (1) may also be injected into plants or sprayed onto vegetation using electrodynamic spraying techniques or other low volume methods, or applied by land or aerial irrigation systems. Compositions for use as aqueous preparations (aqueous solutions or dispersions) are generally supplied in the foR"" of a concentrate containing a high proportion of the actNe ingredient, the concentrate being added to water before use. These concentrates, which may include DCs, SCs, ECs, EWs, MEs SGs, SPs, WPs, WGs and CSs, are often required to withstand storage for prolonged periods and, after such storage, to be capable of addition to water to foR"" aqueous preparations which remain homogeneous for a sufficient time to enable them to be applied by conventional spray equipment. Such aqueous preparations may contain varying amounts of a compound of foR""ula (1) (for example 0.0001 to 10%, by weight) depending upon the purpose for which they are to be used. A compound of foR""ula (1) may be used in mixtures with fertilisers (for example nitrogen-, potassium- or phosphorus-containing fertilisers). Suitable foR""ulation types include granules of fertiliser. The mixtures suitably contain up to 25% by weight of the Compound of foR""ula (1). The invention therefore also provides a fertiliser composition comprising a fertiliser and a compound of foR""ula (1). The compositions of this invention may contain other compounds having biological actNity, for example micronutrients or compounds having similar or complementary fungicidal actNity or which possess plant growth regulating, herbicidal, insecticidal, nematicidal or acaricidal actNity. By including another fungicide, the resulting composition may have a broader spectrum of actNity or a greater level of intrinsic actNity than the compound of foR""ula (1) alone. Further the other fungicide may have a synergistic effect on the fungicidal actNity of the compound of foR""ula (1). The compound of foR""ula (1) may be the sole actNe ingredient of the composition or it may be admixed with one or more additional actNe ingredients such as a pesticide, fungicide, synergist, herbicide or plant growth regulator, where appropriate. An additional actNe ingredient may: provide a composition having a broader spectrum of actNity or increased persistence at a locus; synergise the actNity or complement the actNity (for example by increasing the speed of effect or overcoming repellency) of the compound of foR""ula (1); or help to overcome or prevent the development of resistance to indNidual components. The particular additional actNe ingredient will depend upon the intended utility of the composition. Examples of fungicidal compounds which may be included in the composition of the invention are AC 382042 (Ar-(l-cyano-l,2-dimethylpropyl)-2-(2,4-dichlorophenoxy) pro-pionamide), acibenzolar-S-methyl, alanycarb, aldimorph, anilazine, azaconazole, azafenidin, azoxystrobin, benalaxyl, benomyl, benthiavalicarb, biloxazol, bitertanol, blasticidin S, boscalid (new name for nicobifen), bromuconazole, bupirimate, captafol, captan, carbendazim, carbendazim chlorhydrate, carboxin, carpropamid, carvone, CGA 41396, CGA 41397, chinomethionate, chlorbenzthiazone, chlorothalonil, chlorozolinate, clozylacon, copper containing compounds such as copper oxychloride, copper oxyquinolate, copper sulphate, copper tallate, and Bordeaux mixture, cyamidazosulfamid, cyazofamid (DCF-916), cyflufenamid, cymoxanil, cyproconazole, cyprodinil, debacarb, di-2-pyridyl disulphide l,r-dioxide, dichlofluanid, diclocymet, diclomezine, dicloran, diethofencarb, dinocap, dithianon, dodecyl dimethyl ammonium chloride, dodemorph, dodine, doguadine, edifenphos, epoxiconazole, ethaboxam, ethirimol, ethyl (2)-N-benzyl-N([methyl(methyl-thioethylideneaminooxycarbonyl)amino]thio)-P-a!aninate, etridiazole, famoxadone, fenamidone, fenarimol, fenbuconazole, fenfuram. fenhexamid, fenoxanil (AC 382042), fenpiclonil, fenpropidin, fenpropimorph, fentin acetate, fentin hydroxide, ferbam, ferimzone, fluazinam, fludioxonil, flumetover, flumorph, fluoroimide, fluoxastrobin, fluquinconazole, flusilazole, flusulfamide, flutolanil, flutriafol, folpet, fosetyl-aluminium, fuberidazole, furalaxyl, furametpyr, guazatine, hexaconazole, hydroxyisoxazole, hymexazole, imazalil, imibenconazole, iminoctadine, iminoctadine triacetate, ipconazole, iprobenfos, iprodione, iprovalicarb, isopropanyl butyl carbamate, isoprothiolane, kasugamycin, kresoxim-methyl, LY186054, LY211795, LY 248908, mancozeb, maneb, mefenoxam, mepanipyrim, mepronil, metalaxyl, metalaxyl M, metconazole, metiram, metiram-zinc, metominostrobin, metra-fenone, MON65500 (^V-allyl-4,5-dimethyl-2-trimethylsilylthiophene-3-carboxamide), myc-lobutanil, NTN0301, neoasozin, nickel dimethyldithiocarbamate, nitrothale-isopropyl, nuarimol, ofiirace, organomercury compounds, orysastrobin, oxadixyl, oxasulfuron, oxolinic acid, oxpbconazole, oxycarboxin, pefurazoate, penconazole, pencycuron, phenazin oxide, phosphorus acids, phthalide, picoxystrobin, polyoxin D, polyram, probenazole, prochloraz, procymidone, propamocarb, propamocarb hydrochloride, propiconazole, propineb, propionic acid, proquinazid, prothioconazole, pyraclostrobin, pyrazophos, pyrifenox, pyrimethanil, pyroquilon, pyroxyfur, pyrrolnitrin, quaternary ammonium compounds, quinomethionate, quinoxyfen, quintozene, siithiofam (MON 65500), S-imazalil, simeconazole, sipconazole, sodium pentachlorophenate, spiroxamine, streptomycin, sulphur, tebuconazole, tecloftalam, tecnazene, tetraconazole, thiabendazole, thifluzamide, 2-(thiocyanomethylthio)benzothiazole, thiophanate-methyl, thiram, tiadinil, timibenconazole, tdlclofos-methyl, tolylfluanid, triadimefon, triadimenol, triazbutil, triazoxide, tricyclazole, tridemorph, trifloxystrobin, triflumizole, triforine, triticonazole, validamycin A, vapam, vinclozolin, XRD-563, zineb, ziram, zoxamide and compounds of the foR""ulae: The compounds of foR""ula (1) may be mixed with soil, peat or other rooting media for the protection of plants against seed-borne, soil-borne or foliar fungal diseases. Some mixtures may comprise active ingredients, which have significantly different physical, chemical or biological properties such that they do not easily lend themselves to the same conventional foR""ulation type. In these circumstances other foR""ulation types may be prepared. For example, where one active ingredient is a water insoluble solid and the other a water insoluble liquid, it may nevertheless be possible to disperse each active ingredient in the same continuous aqueous phase by dispersing the solid active ingredient as a suspension (using a preparation analogous to that of an SC) but dispersing the liquid active ingredient as an emulsion (using a preparation analogous to that of an EW). The resultant composition is a suspoemulsion (SE) foR""ulation. Step I 4,6-Dichloropyrimidin-5-ylamine (20.Og) was stirred while hydrazine hydrate (200ml) was added to the solid rapidly over 2 minutes. The texture of the solid changed and ; the mobile phase looked greenish, and the temperature rose to 35°C. The reaction was then cooled, the thick solid was collected and washed with isopropyl alcohol, and was dried to (4,6-dichloro-pyrimidin-5-yl)-hydrazine as a white fluffy solid (16.4g). *H NMR (d6-DMSO) 5 ppm: 4.4-4.6 (bs, 3H), 7.75 (s, 1H)," 8.15 (bs, 2H) Step 2 The product from Step 1 (10.6g) was suspended in trimethylorthofoR""ate (150ml), followed by the addition of concentrated hydrochloric acid (2ml). The colour changed to orange and the reaction was brought to reflux for 6 hours with stirring. The bright yellow reaction mixture was cooled and the solid collected, washed with diethyl ether and dried overnight to give 5-chloro-l,2-dihydropyrimido[5,4-e][l,2,4]triazine as a yellow solid (5.5g). JH NMR (d6-DMSO) 5 ppm: 6,2 (fd, 1H), 7.4 (s,lH), 8.0 (bs,lH), 9.1(bs,lH) Step 3 The product from Step 2 (5.5g) was suspended in ethanol (350ml) and a solution of bromine (3.1ml) in ethanol (50ml) was added slowly over a period of 10 minutes. The suspension dissolved to give a dark straw colour. After 15 minutes of stirring, water (5ml) was added and stirring was continued for 3 hours. The reaction mixture was then allowed to stand for 18 hours. The liquid was decanted from the solid, which was washed with diethyl ether, collected and discarded. The combined washings were evaporated to give Nbrown sludge, which was dissolved in water (5ml) and neutralised with aqueous sodium bicarbonate and then extracted with DC1-4 (2 x 200ml) to give a yellow solution. This solution was dried over magnesium sulphate and evaporated to give 6-amino-[l,2,4]triazine-5-carboxylic acid ethyl ester as a straw solid (3.6g). 1HNMR (CDC13) 5 ppm: 1.5 (t,3H), 4.5 (q,2H), 6.4-6.7 (bs,2H), 9.3 (s,lH). Step 4 The product from Step 3 (1.4g) was dissolved in dry toluene (30 ml), and DMAP (l.Og) added to give a dark brown solution. To this was added (2,4,6-trifluoro-phenyl)-acetyl chloride (1.7g) in toluene (20ml), giving a thick precipitate. The stirred suspension was heated for 5 hours at reflux, and the reaction was then cooled and the solid collected and washed with diethyl ether to yield an off white solid. The pale red filtrate was evaporated to give a viscous liquid, which was purified by column chromatography on silica gel (40-60) eluting with diethyl ether to give 6-[2-(2,4,6-trifluorophenyI)-acetylamino]-[l,2,4]triazine-5-carboxylic acid ethyl ester as a viscous oil which solidified (l.Og). Step 5 The product of Step 4 (l.Og) was dissolved in DMF (20ml) and potassium carbonate (0.5g) was added and the reaction brought to 130°C for 2 hours. The reaction was cooled and the solvent evaporated to give a solid, which was triturated with diethyl ether. The solid was dissolved in water (10ml) and acidified with 2M aqueous hydrochloric acid, which precipitated a dark brown solid (0.30g)."The aqueous fraction was acidified again with 2M aqueous hydrochloric acid and extracted with ethyl acetate. The organic layers were evaporated to give a brown solid, which was triturated with diethyl ether and collected to give pure 6-(2,4,6-trifluorophenyl)-8H-pyrido[3)2-e][l,234]triazine-5)7-dione as a pale brown solid (0.160g). !H NMR (CD3OD) 5 ppm: 6.95(t, 2H), 9.65(s, 1H). Step 6 The product from Step 5 (0.05g) was dissolved in phosphorus oxychloride (3.0ml) and brought to 100°C for 2 hours. The reaction was cooled and the solvent evaporated to give an oil, which was diluted with DC1-4 (100ml) and washed with aqueous sodium bicarbonate. The DC1-4 fraction was filtered through phase separation paper and evaporated to give 5,7-dichloro-6-(2,4>6-trifluorophenyl)-pyrido[372-e][l)2,4]triazine as a reddish oil, which was used without further purification. -Step 7 The product from Step 6 (0.02g) was dissolved in DC1-4 (3.0ml) and then isopropylamine (1.0ml) was added, with stirring. The reaction was stirred in a sealed tube at room temperature (32°C) for 30 minutes, the volatiles were evaporated and the residue was purified by flash column chromatography on silica gel (40-60) eluting with diethyl ether to yield an inseparable mixture of 4:6 [7-chloro-6-(2,4,6-trifluorophenyI)-pyrido[3,2-e][l,2,4]-triazin-5-yIJ-isopropylamine, and [5-chloro-6-(2,4,6-trifluorophenyl)-pyrido[3,2-e][l,2,4J-triazin-7-ylj-isopropylamine, as a yellow oil (0.006g). [7-Chloro-6-(2,4,6-trifluorophenyI)-p>Tido[372-e][l,2,4]triazin-5-yl]-isopropyIarnine; !H NMR (CDCI3) 8 ppm: 1.15 (d,6H), 3.5 (b,lH). 6.7 (bflatJH), 6.9 (t,2H). 9.85 (s,lH). [5-Chloro-6-(2A6-trifluorophenyl)-pyrido[3,2-e][l,2,4]triazin-7-yl]-isopropylarnine: !H NMR (CDCI3) 5 ppm: 1.3 (d,6H), 4.75 (m,lH), 4.85 (bd,lH), 7.0 (t,2H). 9.S0 (s,lH). EXAMPLE 2 This Example illustrates the preparation of [7-fluoro-6-(2,4,6-trifluorophenyl)-pyrido[3,2-e]-[l,2,4]triazin-5-yl]-isopropylamine (Compound No. 3, Table 26) and Ar,-5->A'"-7-diisopropyl-6-(2,4,6-trifluorophenyl)-pyrido[3,2-e][i;2,4]triazine-5,7-diamine (Compound No. 3,Table 129). Step 1 5,7-Dichloro-6-(2,4,6-trifluorophenyl)-pyrido[3,2-e]triazine (1.0 g), potassium fluoride (0.53 g, spray dried) were suspended in sulpholane (5 ml) and heated to 130°C for 16 hours. After cooling, the mixture was poured into water and extracted with ethyl acetate. The organic phase was washed with water, brine and then dried over sodium sulphate. The ethyl acetate was evaporated and the residue purified by flash chromatography eluting with cyclohexane:ethyl acetate, 3:1, to give 5,7-difluoro-6-(2,4,6-trifluorophenyl)-pyrido[3,2-e]-[l,2,4]triazine as a yellow powder (0.51 g), m.p. 160-161 °C. Step 2 The product from Step 1 (0.20 g) was added to a mixture of isopropylamine (0.060g), potassium carbonate (0.140 g) and a catalytic amount of DMAP in DMF (3 ml). The mixture was stirred at room temperature for 19 hours, and then poured into ethyl acetate, washed with water and brine and the organic phase dried over sodium sulphate. The ethyl acetate was evaporated and the residue was purified by flash chromatography eluting with cyclo- hexane:ethyl acetate, 3:1, to give: [7-fluoro-6-(2,4,6-trilluorophenyl)-pyrido[3,2-e][ 1 ;2,4]triazin-5-yl]-isopropylamine (0.040 g),m.p. 91-92°C,and Ar-5-,vVf-7-diisopropyl-6-(2,4,64rifluorophenyl)-pyrido[3,2-e][l,2,4]triazine-5,7-diam (0.130 g),m.p. 166-167°C. Stepl 5-Chloro-3-methylsulfanyl-[l,2,4]triazine-6-carboxylic acid ethyl.ester (2.15 g, prepared according to the procedure in EurJ.Med.Chem.-Chim.Ther. (19S0), 15, 269) was dissolved in dioxane (300 ml) and cooled to 5°C. A solution of ammonia in methanol (3.0 ml of a 7M solution) was added dropwise the colour changed and a small exotheR"" was noticed. After about 5 minutes the reaction mixture was evaporated to give a sludge, which was extracted with ethyl acetate and was washed with water. The ethyl acetate was dried over magnesium sulphate and evaporated, and the residue purified by flash column chromatography on silica gel eluting with diethyl ether, to give 5-amino-3-methylsulfanyl-[ 1,2,4]-triazine-6-carboxyhc acid ethyl ester as a buff solid (1.3 g). *H NMR (CDCI3) 5 ppm: 1.4 (t,3H), 2.6 (s,3H), 4.5 (q,2H), 5.6 (bs,lH), 7.9 (bs,lH). Step 2 The product from Step 1 (0.428 g) was dissolved in dry toluene (30 ml), and DMAP (0.250 g) was added to give dark a brown solution. 2-Chloro-6-fIuorophenylacetyl chloride (0.414 g) in dry toluene (20 ml) was then added to give a thick precipitate, and the stirred suspension was heated for 3 hours at reflux. The reaction was cooled and the solid collected and washed with diethyl ether to yield an off white solid. The pale red filtrate was evaporated to give a liquid that was purified by flash column chromatography eluting with diethyl ether, to give 5-[2-(2-chloro-6-fluorophenyl)-acet}ianiino]-3-methylsulfanyl-[l,2,4]triazine-6-carboxylic acid ethyl ester as a viscous oil (0.160 g). !H NMR (CDCI3) 5 ppm: 1.45 (t,3H), 2.65 (s,3H)A5 (q,2H), 7.0 (m,lH), 7.2 (m,2H). Step 3 The product from Step 2 (0.20 g) was dissolved in DMF (10 ml) and potassium carbonate (0.50 g) was added and the reaction brought to 130°C for 2 hours. The reaction was cooled and the solvent evaporated to give a solid, which was triturated with diethyl ether. Thetsolid was dissolved in water (10ml) and then acidified with 2M aqueous hydrochloric acid. The aqueous fraction was evaporated to give a solid, which was then triturated with methanol to give 3-methylsulfanyl-7-(2-chloro-6-fluorophenyl)-5H-pyrido[2,3-e][ 1,2,4]-triazine-6,S-dione as an orange solid (0.210 g). 1HNMR (D6-DMSO) 5 ppm: 3.5 (s,3H), 7.0 (m,lH), 7.2 (m,2H). Step 4 The product from Step 3 (0.10 g) was suspended in 1,2-dichloroethane (5 ml) and phosphorus oxychloride (1.0 ml) was added dropwise to the suspension. The suspension dissolved, and two drops of DMF were added. The reaction was re fluxed for 3 hours and became dark but clear. The reaction was cooled and evaporated to give a dark brown oil. Saturated aqueous sodium bicarbonate (2 ml) was added and the mixture was extracted with DC1-4. The DC1-4 fraction was dried and evaporated to give an oil, which was purified by flash column chromatography on silica gel, eluting with diethyl ether, to give 6,8-dichloro-3-methylsulfanyI-7-(2-chloro-6-fluorophenyl)-p>/rido[2,3-e][l:,2,4]triazine as a yellow oil (0.025g). 1H NMR (CDCI3) 5 ppm: 2.8 (s,3H), 7.35 (m,lH), 7.45 (d,lH), 7.55 (m,lH). Step 5 To the product from Step 4 (O.D25 g) in DC1-4 (5.0 ml), isopropylamine (0.10 g) was added dropwise. The reaction was stirred at room temperature for 1 hour and the volatiles were evaporated to give a yellow oil, which was purified by flash column chromatography eluting with diethyl ether, to give a 1:1 mixture of the two isomers as a yellow oil (0.015 g): EXAMPLE 4 This Example illustrates the fungicidal properties of the compounds of the general foR""ula Compounds were tested in a leaf disk assay, with methods described below. Test compounds were dissolved in DMSO, and diluted into water to 200 ppm. Erysiphe graminis f.sp. hordei (barley powdery mildew): barley leaf segments were placed on agar in a 24-well plate and sprayed with a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the fungus. After appropriate incubation the activity of a compound was assessed four days after inoculation as preventive fungicidal activity. Erysiphe graminis f.sp. tritici (wheat powdery mildew): wheat leaf segments were placed on agar in a 24-well plate and sprayed with a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the fungus. After appropriate incubation the activity of a compound was assessed four days after inoculation "as preventive fungicidal activity. Puccinia reconduct f.sp. tritici (wheat brown rust): wheat leaf segments were placed on agar in a 24-well plate and sprayed with a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the fungus. After appropriate incubation the activity of a compound was assessed nine days after inoculation as preventive fungicidal activity. Pyrenophora teres (barley net blotch): barley leaf segments were placed on agar in a 24-well plate and sprayed with a solution of the test compound. After allowing to dry completely, for between 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the ftingus. After appropriate incubation the activity of a compound was assessed four days after inoculation as preventive fungicidal activity. Pyricularia oryzae (rice blast): rice leaf segments were placed on agar in a 24-well plate and sprayed with a solution of the test compound. After allowing to dry completely, for between . 12 and 24 hours, the leaf disks were inoculated with a spore suspension of the fungus. After appropriate incubation the activity of a compound was assessed four days after inoculation as preventive fungicidal activity. The following compounds gave greater than 60% control of disease (number of compound first, followed by table number in brackets): Eiysivhe graminis f.sp. hordei, Compounds 3 (26), 23 (26), 5S (26), 23 (129), 58 (129); E)ysiphe graminisfsp.tnticl Compounds 3 (11), 3 (16), 3 (26).12 (26), 23 (26), 5S (26); Pucania reconditaf.sp. tritici, Compounds 3 (11), 3 (16). Pyrenophora teres, Compounds 12 (26). 23 (26), 58 (26); Pyricularia oryzae, Compounds 3 (26). 12 (26), 23 (26), 58 (26). CLAIMS 1. wherein W, Z and one of X and Y areN and the other one of X and Y is CRl; R8 is H, halo, C1-4 alkyl, C1-4 alkoxy,C1-4 alkylthio or halo(C1-4)alkyl; R and R are independently H, halo, C1-8 alkyl, C1-8alkoxy, C1-8 alkylthio, C2-8 alkenyl, C2-8 alkynyl, cyano orNR3R4, provided that at least one of R and R2 is NR R4; R1 is halo, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-8 cycloalkyl, C3-8cycloalkyl(Ci.6.)alkyl, C1-8 alkoxy, C1-8 alkylthio, aryl, aryloxy, arylthio, heteroaryl, heteroaryloxy, heteroarylthio, aryl(C1-4)alkyl, aryl(C1-4)alkoxy, heteroaryl(C1-4)alkyl, heteroaryl(C1-4)alkoxy, aryrl(C1-4alkylthio, heteroaryl(C1-4)alkylthio, morpholino, piperidino orpyrrolidino; R3 and R4 are independently H, C1-8alkyl, C2-8 alkenyl, C2-8 alkynyl, aryl, aryl(Cj-8)alkyl, C3-8 cycloalkyl, C3-8cycloalkyl(Ci.6)alkyl, heteroaryl, heteroaryl(C|-8)a!kyl, NR5R6, provided that not both R3 and R4 are H or NR5R6, or R3 and R4 together form a C3.7 alkylene or C3.7 alkenylene chain optionally substituted with one or more C1-4 alkyl or C 1.4 alkoxy groups, or, together with the nitrogen atom to which they are attached, R3 and R4 form a morpholine, thiomorpholine, thiomorpholine S-oxide or thiomorpholine S-dioxide ring or a piperazine or piperazine iV-(C1-4)alkyl (especially N-methyl) ring; and R5 and R6 are independently H, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, aryl, aryl(C1-8)alkyl, C3-8 cycloalkyl, C3-8 cycloalkyl(C1-6)alkyI, heteroaryl or heteroaryl(C1-8)alkyl; any of the foregoing alkyl, alkenyl, alkynyl or cycloalkyl groups or moieties (other than for Rs) being optionally substituted with halogen, cyano, C1-6 alkoxy, C1-6 alkylcarbonyl,C1-6 alkoxycarbonyl, C1-6 haloalkoxy, C1-6 alkylthio, tri(C1-4)alkylsilyl, C1-6 alkylamino or C1-6 dialkylamino, any of the foregoing morpholine, thiomorpholine, piperidine, piperazine and pyrrolidine rings being optionally substituted with C1-4 alkyl (especially methyl), and A compound according to claim 1 wherein W, Z and one of X and Y are N and the other one of X and Y is CH. A compound according to claim 1 or 2 wherein R" is NR'R . A compound according to claim 3 wherein R is halo. A compound according to any one of the preceding claims wherein R3 is C1-8 alkyl, halo(C1-8)alkyl, hydroxy(C1-8)alkyI, C1-4 alkoxyC1-8)alkyI, C1-4 alkoxyhalo(C1-8)alkyl, tri(C1-4)alkylsilyl(C1-6)alkyl, C1-4 alkylcarbonyl(C1-8)alkyl, C1-4 alkylcarboriylhalo(C1-8)aIkyl, phenyl(C1-4)alkyl, C2-s alkenyl, halo(C2-8)aIkenyl, C2-8 alkynyl, C3-8 cycloalkyl optionally substituted with chloro, fluoro or methyl C3-8 cycloaIkyl(C1-4)alkyl, phenylamino, piperidino or morpholino, the phenyl ring of phenylalkyl or phenylamino being optionally substituted with one, two or three substituents selected from halo, C1-4 alkyl, halo(C1-4)alkyl, C1-4 alkoxy and halo- (C1-4)alkoxy; and - - R4 is H, C1-4 alkyl, halo(C1-4)alkyl or amino, or R3 and R4 together form a C3-7 alkylene or alkenylene chain optionally substituted with methyl, or, together with the nitrogen atom to which they are attached, R3 and R4 form a morpholine, thiomorpholine, thiomorpholine S-oxide or thiomorpholine S-dioxide ring or a piperazine or piperazine N-(C1-4)alkyI (especiallyN-methyl) ring, in which the morpholine or piperazine rings are optionally substituted with methyl. A compound according to any one of the preceding claims wherein R1 is phenyl optionally substituted with from one to five halogen atoms or with from one to three substituents selected from halo. C1-4 alkyl, halo(C1-4)alkyL C1-4 alkoxy or halo(C1-4)alkoxy, pyridyl optionally substituted with from one to four halogen atoms or with from one to three substituents selected from halo, C1-4 alkyl, halo(C1-4)alkyl, C1-4 alkoxy or halo(C1-4)alkoxy, 2- or 3-thienyl optionally substituted with from one to three halogen atoms or with from one to three substituents selected from halo, C1-4 alkyl, haIo(C1-4)aIkyls C1-4 alkoxy or haIo(C1-4)alkoxy, or piperidino or morpholino both optionally substituted with one or two methyl groups. A compound according to claim 6 wherein R1 is 2,6-difluorophenyl,2-fluoro-6-chlorophenyl, 2,5,6-trifIuorophenyi, 2,4,6-trifluorophenyl, 2,6-difluoro-4-methoxy-phenyl orpentafluorophenyl. A compound according to claim 1 wherein W, Z and one of X and Y are N and the other one of X and Y is CR8; R8 is H, halo, C1-4 alkyl,.C1-4 alkoxy, C1-4 alkylthio or halo(C|.4)alkyl; one of R and R2 (preferably R2) is NR3R4 and the other is halo; R1 is halo, C1-8lkyl, C2-8alkenyl, C2-8 alkynyl, C3-8cycloalkyl, C3-8cycloaLKcyl(C1-6)- alkyl, C1-8 alkoxy, C3.s alkylthio, aryl, aryloxy, arylthio, heteroaryl, heteroaryloxy, heteroarylthio, aryl(C1-4)alkyI, aryl(C1-4)alkoxy, heteroaryl(C1-4)alkyl, heteroaiyl- (C1-4)alkoxy, aiyl(C1-4)alkylthio, heteroaiyl(C1-4)alkylthio, morpholino, piperidino or pyrrolidino; R3 and R4 are independently H, C1-8 alkyl, C3-8alkenyl, C2-8 alkynyl, aryl, aryl(Cj-s)- alkyl, C3-8 cycloalkyl, C3-8cycloalkyl(C1-6)alkyl, heteroaryl, heteroaryI(C1-8)alkyl, NR5R6, provided that not both R3 and R4 are H or NR5R6, or R3 and R4 together form a C3-7 alkylene or C3-7 alkenylene chain optionally substituted with one or more C1-4 alkyl or C1-4 alkoxy groups, or, 1 I together with the nitrogen atom to which they are attached, RJ and R form a morpholine, thiomorpholine, thiomorpholine S-oxide or thiomorpholine S-dioxide ring or a piperazine or piperazine .Y-(C1-4)aIlcyl (especially iV-methyl) ring; and R" and R6 are independently H. C1-4 alkyl, C2-8alkenyl, C2-8alkynyl. aryl, aryl(C1-8)-alkyl, C3-8 cycloalkyl,C3-8cycIoa!kyKCi-o)alkyI, heteroaryl or heteroaryI(C1-8)aIkyl; any of the foregoing alkyl alkenyl. alkynyl or cycloalkyl groups or moieties (other than for Rs) being optionally substituted with halogen, cyano, C1-6 alkoxy, C1-6 alkylcarbonyl, C]-6aIkoxycarbonyl. C1-6haloalkoxy, C1-6alkylthio, tn(C1-4)alkyIsilyl, C1-6 alkylamino or C1-6 dialkylaimno. iiny of the foregoing morpholine, thiomorpholine, piperidine, piperazine and pyrrolidine rings being optionally substituted with C1-4 alkyl (especially methyl), and any of the aryl, heteroaryl, aryloxy or heteroaryl groups being optionally substituted with one or more substituents selected from halo, hydroxy, mercapto, C1-6 alkyl, C2-6 alkenyl, C2-6alkynyl, C1-6 alkoxy, C2-6 alkenyloxy, C2-6 alkynyloxy, halo(C1-6)alkyl, haIo(C1-6)alkoxy,C1-6 alkylthio, halo(C1-6)alkylthio, hydroxy(C1-6)alkyl,. C1-4 alkoxy(C1-6)aIkyl, C3-6 cycloalkyl, C3-6 cycloalkyl(C1-4)alkyl, phenoxy, benzyloxy, benzoyloxy, cyano, isocyano, thiocyanato, isothiocyanato, nitro, -NR"R", -NHCOR', -NHCONRf,R", -CONRf,,R"", -S0R"',-OS02Rm, -COR, ", -CR'"=NR"" or -N=CR,nR"', in which R'" and R"" are independently hydrogen, C1-4 alkyl, halo-(C1-4)alkyl, C,A alkoxy, halo(C1-4)alkoxy, C1-4 alkylthio, C3-6 cycloalkyl, C3-6 cycloalkyl(C1-4)alkyl, phenyl or benzyl, the phenyl and benzyl groups being optionally substituted with halogen, C1-4 alkyl or C1-4 alkoxy. A compound according to claim 1 wherein W, Z and one of X and Y are N and the other one of X and Y is CRS; R8 is H, halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio or halo(C1-4)alkyl; one of R and R3 (preferably R ) is NR R and the other is halo; R1 is halo, C1-8 alkyl, C2-s alkenyl, C2-8 alkynyl, C3-8 cycloalkyl, C3-8 cycloalkyl(C1-4)- alkyl,"C1-8 alkoxy, C1-8alkylthio, aryl, aryloxy, arylthio, heteroaryl, heteroaryloxy, heteroarylthio, aryl(C1-4)alkyl, aryl(C1-4)alkoxy, heteroaryl(C1-4)alkyl, heteroaryl- (C1-4)alkoxy, aryl(C1-4)alkylthio, heteroaryl(C1-4)alkylthio, morpholino, piperidino or pyrrolidino; R3 is C1-4 alky], halo(C1-4)a]kyI, C2-4 alkenyl, C1-8 cycloalkyl, C3-6 cycIoa!kyl(C1-4)-alkyl or phenylamino in which the phenyl ring is optionally substituted with one, two or three substituents selected from halo, C1-4 alkyl, ha!o(C1-4)aIkyl, C1-4 alkoxy and halo(C1-4)alkoxy; and R4 is H/C1-4 alky] or amino, or R3 and R4 together form a C4-6 alkylene chain optionally substituted with C1-4 alkyl or C1-4 alkoxy, or, together with the nitrogen atom to which they are attached, R3 and R4 form a morpholine, thiomorpholine, thiomorpholine S-oxide or thiomorpholine S-dioxide ring or a piperazine or piperazine N-(C1-4)alkyl (especially iV-methyl) ring; any of the alkyl, alkenyl, alkynyl or cycloalkyl groups or moieties (other than for Rs) being optionally substituted with halogen, cyano, C1-4 alkoxy, C1-6alkylcarbonyl, C1-4 alkoxycarbonyl, C1-4 haloalkoxy, C1-6alkylthio, tri(C1-4)alkylsilyI, Calkylamino or C1-6 dialkylamino, any of the foregoing morpholine, thiomorpholine, piperidine, piperazine and pyrrolidine rings being optionally substituted with C1-4 alkyl (especially methyl), and any of the aryl or heteroaryl groups or moieties being optionally substituted with one or more substituents selected from halo, hydroxy, mercapto, C1-4 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C2-6 aikenyloxy, C2-6 alkynyloxy, halo(C!.6)alkyl, halo(C-1 6)alkoxy, C1-6 alkylthio, halo(C1-6)alkyIthio, hydroxy(C1-6)alkyl, C1-4alkoxy(C1-6)-alkyi, C3-6 cycloalkyl, C3-6 cycloalkyl(C1-4)alkyl, phenoxy, benzyloxy, benzoyloxy, cyano, isocyano, thiocyanato, isothiocyanato, nitro, -NRmR"", -NHCOR'", -NHCONRmRm, -CONRmRm', -S02Rw, -OS02Rw, -CORm, -CR,M=NRn" or -N=CR',,R,,M, in which R"' and R,m are independently hydrogen, C1-4 alkyl, halo-(C1-4)alkyl, C1-4 alkoxy, halo(C1-4)alkoxy, C1-4 alkylthio, C3-6 cycloalkyl C3-6 cycloalkyl(C1-4)alkyl, phenyl or benzyl, the phenyl and benzyl groups being optionally substituted with halogen, C1-4 alkyl or C1-4 alkoxy. A compound according to claim 1 wherein W, Z and one of X and Y are N and the other one of X and Y is CR8; R8 is H, halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio or halo(C|.4)alkyl; R and R2 are independently H, halo, C1-3 alkyl, C1-8 alkoxy, C1-8 alkylthio, C2-8 alkenyl, C2-8 alkynyl, cyano or NR R , provided that at least one of R and R" (preferably R2) is NR3R4; R1 is optionally substituted phenyl: RJ and R are independently H. C1-8alkyl, C2-8 alkenyh C2-8 alkynyl aryl, aryl(C1-8)- ulkyl, C3-8 cycloalkyl, C3-8 cycloalkyKC1-4alkyl, heteroaryl, heteroaryI(C]-s)aIkyI, NR5R6, provided that not both R:" and R4 are H or NR5RC, or R3 and Ra together form a C3-7 alkylcne or C3-7 alkenylene chain optionally substituted with one or more C1-4 alkyl or C1-4 alkoxy groups, or, together with the nitrogen atom to which they are attached, R3 and R" form a morphoiine, thiomorpholine. thiomorpholine S-oxide or thiomorpholine S-dioxide ring or a piperazine or piperazine A-(C1-4)alkyl (especiallyN-methyl) ring; and R" and RD are independently H. C1-8alkyl C1-8alkenyl, C2-8 alkynyl. aryl, aryl(C1-8)- alkyl, C3-8 cycloalkyl, C3-8cycIoalkyl(C1-6)alkyI, heteroaryl or heteroaryl(C1-8)aIkyl; any of the alkyl, aikenyl, alkynyl or cycloalkyl groups or moieties (other than for R ) being optionally'substituted with halogen, cyano,C1-6 alkoxy, C1-4alkylcarbonyl, C1-6 - r alkoxycarbonyl, C,.s haloalkoxy, C1-6 alkylthio, tri(C1-4)alkylsilyL C1-6 alkylamino or C1-6 dialkylamino, any of the foregoing morpholine, thiomorpholine, piperidine, piperazine and pyrrolidine rings being optionally substituted with C1-4 alkyl (especially methyl), and any of the aryl or heteroaryl groups or moieties, including the phenyl group of R , being optionally substituted with one or more substituents selected from halo, hydroxy, mercapto, C1-6 alkyl, C2-6alkenyl, C2-6 alkynyl, C1-4 alkoxy, C1-6alkenyloxy, C2-6 alkynyloxy, halo(C1-6)alkyl, halo(C1-6)alkoxy, C1-6alkylthio, halo(C1-6)alkylthio, hydroxy(C1-6)alkyI,'C1-4 alkoxy(C1-6)alkyl, C3-6 cycloalkyl, C3-6 cycloalkyl(C1-4)aIkyl, phenoxy, benzyloxy, benzoyloxy, cyano. isocyano, thiocyanato, isothiocyanato, nitro, -NR,"R"", -NHCOR'", -NHCONR""R"", -CONR"'R"", -S02R", -OS02R"', -COR"', -CR"-NR"" or -N=CRmR"', in which R"' and R,m are independently hydrogen, C3-8 alkyl, halo(C1-4)alkyl, C1-4 alkoxy, halo(C1-4)aIkoxy, C1-4 alkylthio, C3-6 cycloalkyl, C3-6 cycloalkyl(C1-4)alkyl, phenyl or benzyl, the phenyl and benzyl groups being optionally substituted with halogen. C1-4 alkyl or C1-4 alkoxy. A compound according to claim 1 wherein W, Z and one of X and Y are N and the other one of X and Y is CR8; R8 is H, halo, C1-4 alky], C1-4 alkoxy, C1-4 alkylthio orha!o(C1-4)alkyl; R is H, halo, C1-4 alkyl), C1-4alkoxy or cyano; R is phenyl optionally substituted with from one to five halogen atoms or with from one to three substituents selected from halo, C1-4 alky), haIo(C1-4)aIkyl, C1-4 alkoxy or ha!o(C1-4)alkoxy, pyridyl optionally substituted with from one to four halogen atoms or with from one to three substituents selected from halo, C1-4 alkyl, halo(C1-4)alkyl, C1-4 alkoxy or halo(C1-4)alkoxy, 2- or 3-thienyl optionally substituted with from one to three halogen atoms or with from one to three substituents selected from halo, C alkyl, halo(C1-4)alkyl, C1-4alkoxy or halo(C1-4)alkoxy, or piperidino or morpholino both optionally substituted with one or two methyl groups; '* R2 is NR3R4; R3 is C|.8 alkyl, halo(CN8)alkyl, hydroxy(C1-8)alkyl, C1-4 alkoxy(d.8)alkyI, C1-4 alkoxyhaIo(C1-8)alkyl, tri(C1 _4)alkylsilyl(C1 _6)alkyl, C1-4 alkylcarbonyl(C1-8)alkyl, C1-4 alkylcarbonylhalo(C1-8)alkyl, phenyl(C1-4)alkyk C2-8 alkenyl, halo(C2-8)alkenyl, C1-8 alkynyl, C1-8 cycloalkyl optionally substituted with chloro, fluoro or methyl, C3-8 cycloalkyl(C1-4)aIkyl, phenylamino, piperidino or morpholino, the phenyl ring of phenylalkyl or phenylamino being optionally substituted with one, two or three substituents selected from halo, C1-4 alkyl, halo(C1-4)alkyl, C1-4 alkoxy and halo- (C1-4)alkoxy; and R4 is H, C1-4alkyl, halo(C1-4)aIkyl or amino, or R3 and R4 together form a C3-7 alkylene or C3.7 alkenylene chain optionally substituted with methyl, or, together with the nitrogen atom to which they are attached, R3 and R4 form a morpholine, thiomorpholine, thiomorpholine S-oxide or thiomorpholine S-dioxide ring or a piperazine or piperazine jV-(C1-4)alkyl (especially TV-methyl) ring, in which the morpholine or piperazine rings are optionally substituted with methyl A compound according to claim 1 wherein W, Z and one of X and Y are N and the other one of X and Y is CR8; R8 is H, halo, C1-4 alkyl, C3-8 alkoxy or halo(C1-4)aIkyl; R is halo; R1 is phenyl optionally substituted with from one to five halogen atoms or with from 4 A method of combating or controlling phytopathogenic ftingi which comprises applying to a plant, to a seed of a plant, to the locus of the plant or seed or to soil or to any other plant growth medium, a fungicidally effective amount of a compound according to claim 1 or a composition according to claim 15.

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