Title of Invention

PYRIMIDO COMPOUNDS HAVING ANTIPROLIFERATIVE ACTIVITY

Abstract

Disclosed are novel pyrimido compounds of the formula (I) wherein R<sup>1</sup> to R<sup>9</sup> are as defined in the specification, that are selective inhibitors of the Src family of tyrosine kinases. These compounds and their pharmaceutical^ acceptable salts are anti-proliferative agents useful in the treatment or control of solid tumors, in particular breast, colon, hepatic and pancreatic tumors. Also disclosed are pharmaceutical compositions containing these compounds and the use for treating cancer.

Full Text

Pyrimido compounds having antiproliferative activity (II) or a pharmaceutically acceptable salt thereof, wherein R1 is selected from the group H, C1-10 alkyl, CMO alkyl substituted by up to three groups selected from aryl, cycloalkyl, heteroaryl, heterocycle, NR10RH, OR12, SR12, halogen, COR13, C02R13, CONR13R14, S02NRI3R14, SOR13, S02R13, CN and N02( wherein the aryl, cycloalkyl, heteroaryl, and heterocycle groups may each independently be substituted by up to three groups selected from NR10RU, OR12, SR12,, halogen, COR13, C02R13, CONR13R14, S02NR13R14, SOR13, S02R13, CN and N02, aryl, aryl substituted by up to three groups selected from lower alkyl, NR R , OR , SR12, halogen, COR13, C02R13, CONRI3R14, S02NR13R14, SOR33, S02R13, CN and N02, heteroaryl, heteroaryl substituted by up to three groups selected from lower alkyl, NR10RH,, OR12, SR12, halogen, COR13, C02R13, CONR13R14, S02NR13R14, SOR13, S02R13, CN and N02, heterocycle, heterocycle substituted by up to three groups selected from lower alkyl, NR10RU, OR12, SR12, halogen, COR13, C02R13, CONR13R14, S02NR13RM, SOR13, S02R13, CN and N02, C3.10 cycloalkyl, C3.10 cycloalkyl substituted by up to three groups selected from lower alkyl NRl0Rl\ OR12, SR12, halogen, COR13, C02R13, CONRl3R14, S02NR13R14, SOR13, S02R13,CNandN02, C2_10alkenyl, C2-10 alkenyl substituted by up to three groups selected from NR10Rn, OR12, SR12, halogen, COR13, C02R13, CONR13R14, S02NRI3R14, SOR13, S02R13, CN and N02) and C2-10 alkynyl, substituted by up to three groups selected from NR10R11 , OR , SR1 , halogen, COR13, C02R13, CONR13R14, S02NR13R14, SOR13, S02R13, CN and N02; R", R and R are independently selected from the group consisting of H, NR10R11, OR12, SR12, C1-10 alkyl, C1-10 alkyl substituted by up to three groups selected from cycloalkyl, heteroaryl, heterocycle, NR10RU, OR12, SR12, halogen, COR13, C02R13, CONR13R14, S02NR13R14, SOR13, S02R13, CN and N02; and wherein the cycloalkyl, heteroaryl, and heterocycle groups may each independently be substituted by up to three groups selected from lower alkyl, NR10RH, OR12, SR12, halogen, COR113, C02R13, C0NR13R14, S02NR13R14, SOR13, S02R13, CN and N02, heteroaryl, heteroaryl substituted by up to three groups selected from lower alky!, NR10RH, OR12, SR12, halogen, COR13, C02R13, CONR13R14, S02NR13R14, SOR13, S02R13, CN and N02, heterocycle, substituted by up to three groups selected from lower alkyl, NR10Rn3 OR12, SR12, halogen, COR13, C02R13, CONR13R14, S02NR13Ru, SOR13, S02R13, CN and N02> C3-10 cyclo alkyl, C3-10 cycloalkyl substituted by up to three groups selected from lower alkyl, NR10RU, OR12, SR12, halogen, COR13, O02R13, CONR13R14, S02NR13R14, SOR13, S02R13, CN and N02, C2_i0alkenyl, C2-10 alkenyl substituted by up to three groups selected from NR10R1!, OR12, SR12, halogen, COR13, C02R13, CONR13R14, S02NR13R14, SOR13, S02R13, CN and N02, C2-10 alkynyl, and C2-10 alkynyl substituted by up to three groups selected from NRI0RU, OR12, SR12, halogen, COR13, C02R13, CONR13R14, S02NRI3R14, SOR13, S02R13, CN andNQ2, provided that at least one of R , R or R is not H; R5, R5, R7 and R are independently selected from the group H, lower alkyl, lower alkyl substituted by hydroxy or alkoxy, NRI5R16, OH, OR17, SR17, halogen, COR17, C02R17, CONR17R18, S02NR17R18, SOR17, S02R17, and CN; R is selected from the group H, n1? R20 O R \ /R O II \/ II 21 -C~0-C-0-C-R21and COR17; R10 and R11 are independently selected from the group H, COR13, C02R13, CONR13R14, S02R13, S02NR13R14, lower alley!, lower alkyl substituted by hydroxy, alkoxy or NR R , cycloalkyl, cycloalkyl substituted by hydroxy, alkoxy, lower alkyl,orNR^R , heterocycle, and heterocycle substituted by hydroxy, alkoxy, lower alkyl, or NR1:>R16, or, alternatively, NR10Ril can form a ring having 3 to 7 atoms, said ring optionally including one or more additional hetero atoms and being optionally substituted by the group consisting of one or more lower alkyl, OR12, COR13, C02R13> CONR13R14, SOR13, S02R13, and S02NR13R14; R is selected from the group H, lower alkyl, COR13, CONR13R14, C2-6 alkyl substituted by hydroxy, alkoxy, or NR15R16, cycloalkyl, cycloakyl substituted by hydroxy, alkoxy, lower alkyl, or NR15R16, heterocycle, and heterocycle substituted by hydroxy, alkoxy, lower alkyl, or NR15R16; R and R are independently selected from the group H, lower alkyl, C2-6 alkyl substituted by hydroxy, alkoxy, or NR15R16, cycloalkyl, cycloaklyl substituted by hydroxy, alkoxy, lower alkyl, or NR15Rl , heterocycle, and heterocycle substituted by hydroxy, alkoxy, lower alkyl, or NR R , or, alternatively, NRI3R14 can form a ring having 3 to 7 atoms, said ring optionally including one or more additional hetero atoms and being optionally substituted by the group consisting of one or more lower alkyl, OR , COR , CO2R , CONR R , S02Ri7,andS02NR17R18; heterocycle substituted by hydroxy, alkoxy, lower alkyl, or NR11R16, or, alternatively, NR10R11 can form a ring having 3 to 7 atoms, said ring optionally including one or more additional hetero atoms and being optionally substituted by the group consisting of one or more lower alkyl, OR12, COR13, C02R13, CONRi3Ri4, SOR13, S02R13, and S02NR13R14; R is selected from the group H, lower alkyl, COR13, CONRI3R14, C2-6 alkyl substituted by hydroxy, alkoxy, or NR15R16, cycloalkyl, cycloakyl substituted by hydroxy, alkoxy, lower alkyl, or NR15R16, heterocycle, and heterocycle substituted by hydroxy, alkoxy, lower alkyl, or NR15R16; R and R are independently selected from the group H, lower alkyl, C2-6 alkyl substituted by hydroxy, alkoxy, or NR15R16, cycloalkyl, cycloaklyl substituted by hydroxy, alkoxy, lower alkyl, or NRI5R , heterocycle, and heterocycle substituted by hydroxy, alkoxy, lower alkyl, or NR15R! , or, alternatively, NRl R can form a ring having 3 to 7 atoms, said ring optionally including one or more additional hetero atoms and being optionally substituted by the group consisting of one or more lower alkyl, OR17, COR17, C02R 7, CONR R , S02Ri7, and S02NR17R18; R is selected from the group H,lower alkyl, COR17, and C02R17; and R , R and R are independently selected from the group H, and lower alkyl, or, alternatively, NRI5R16 and NR17R18 can each independently form a ring having 3 to 7 atoms, said ring optionally including one or more additional hetero atoms; R and R are independently selected from the group H, and lower alkyl; and R is selected from lower alkyl, and C2-6 alkyl substituted by hydroxy, alkoxy or NR15R16. These compounds inhibit the Src family of non-receptor tyrosine kinases (SFKs). These compounds and their pharmaceutically acceptable salts have antiproliferative activity and are useful in the treatment or control of cancer, in particular in the treatment or control of solid tumors. In addition these compounds have advantageous bioavailability profiles. This invention is also directed to pharmaceutical compositions containing such compounds and to methods of treating or controlling cancer, most particularly the treatment or control of breast, colon, hepatic and pancreatic tumors. Protein kinases are a class of proteins (enzymes) that regulate a variety of cellular functions. This is accomplished by the phosphorylation of specific amino acids on protein substrates resulting in conformational alteration of the substrate protein. The conformational change modulates the activity of the substrate or its ability to interact with other binding partners. The enzyme activity of the protein kinase refers to the rate at which the kinase adds phosphate groups to a substrate. It can be measured, for example, by determining the amount of a substrate that is converted to a product as a function of time. Phosphorylation of a substrate occurs at the active-site of a protein kinase. Tyrosine kinases are a subset of protein kinases that catalyze the transfer of the terminal phosphate of adenosine triphosphate (ATP) to tyrosine residues on protein substrates. These kinases play an important part in the propagation of growth factor signal transduction that leads to cellular proliferation, differentiation and migration. For example, the Src family of non-receptor tyrosine kinases has been specifically implicated in cancer cell modulation and growth. See D, H. Boschelli and F. Boschelli, "Small molecule inhibitors of Src family kinases," Drugs of the Future 2000, 25(7):717-736. Src over expression has been detected in colon, breast, hepatic and pancreatic tumors, as well as in certain B-cell leukemias and lymphomas. Id at 719. Increased Src expression and activity has also been shown to correlate with an increase in tumor malignancy. Id at 719. Thus, Src inhibitors can be useful as antitumor agents. There are several examples of small molecule inhibitors of protein kinase catalytic activity. In particular, small molecule inhibitors typically block the phosphorylation of substrates by tightly interacting with the protein kinase ATP binding site (or "active site"). See WO 98/24432 and Hennequin L. F. et. al., J. Med. Chem. 2002, 45(6), ppl300. Several of these compounds inhibit multiple targets. For example, W099/61444 (Warner-Lambert) discloses bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines of formula that are asserted to inhibit cyclin dependent kinases Cdkl, Cdk2 and Cdk4 as well as the growth factor receptor tyrosine kinase enzymes PDGFR and FGFR. Some compounds are also asserted to inhibit Cdk6. US Patent No. 6,150,373 (Hoffmann-La Roche Inc.) discloses bicyclic nitrogen heterocycles of formula that are stated to inhibit the T-cell tyrosine kinase p56lck. WO 01/29041 Al and WO 01/29042 (F. Hoffmann-La Roche AG) disclose alkylamino substituted bicyclic nitrogen heterocycles of formula that are stated to inhibit p38 mediated cellular functions and are thus inhibitors of cellular proliferation. WO 01/64679 Al (SmithKline Beecham) discloses l,5-disubstituted-3,4-dihydro-lH-pyrimido[4,5-D]pyrimidin-2-one compounds of formula that are stated to be useful in treating CSBP/P38 kinase mediated diseases. There continues to be a need for easily synthesized, small-molecule compounds effective in inhibiting the catalytic activity of protein kinases, in particular the Src family of non-receptor tyrosine kinases ("SFKs"), for treating one or more types of cancers, particularly solid tumors. It is preferable that such small molecule inhibitors also possess advantageous bioavailability profiles. It is thus an object of this invention to provide such compounds and pharmaceutical compositions containing these compounds. The present invention relates to novel pyrimido compounds capable of inhibiting the activity of SFKs. These compounds are useful in the treatment or control of cancer, in particular the treatment or control of solid tumors. In particular this invention relates to compounds of formula or the pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8 and R are as hereinafter defined. The present invention also relates to pharmaceutical compositions comprising a therapeutically effective amount of one or more compounds of formula I and a pharmaceutically acceptable carrier or excipient. The present invention further relates to a method for treating or controlling solid tumors, in particular treatment or control of breast, lung, colon and prostate tumors, most particularly breast or colon tumors, by administering to a human patient in need of such therapy an effective amount of a compound of formula I and/or a pharmaceutical^ acceptable salt thereof. The present invention is further directed to novel intermediate compounds useful in the preparation of compounds of formula I. As used herein, the following terms shall have the following definitions. "Alkenyl" denotes a straight-chain or branched aliphatic hydrocarbon having at least one set of carbon-carbon double bond, for example vinyl, 2-butenyl, and3-methyl-2-butenyl. "Alkynyl" denotes a straight-chain or branched aliphatic hydrocarbon haying at least one set of carbon-carbon triple bond, for example ethynyl, and 2-butynyl. "Alkyl" denotes a straight-chain or branched saturated aliphatic hydrocarbon having 1 to 10, preferably 1 to 6, and more preferably 1 to 4 carbon atoms. Alkyl groups having 1 to 6 carbon atoms are also referred to herein as "lower alkyi." Typical lower alkyl groups include methyl, ethyl, propyl, isopropyl, butyl, t-butyl, 2-butyl, pentyl and hexyl. As used herein the sample designation C1-4 alkyl means alkyl having from 1 to 4 carbon atoms. "Alkoxy" means an alkyl radical that is attached to the remainder of the molecule by oxygen ( RO -), e.g. methoxy, ethoxy. "Aryl" means an aromatic carbocyclic radical, for example a 6 -10 membered aromatic or partially aromatic ring system. Preferred aryl groups include, but are not limited to, phenyl, naphthyl, tolyl and xylyl. "Cycloalkyl" means a non-aromatic, partially or completely saturated cyclic aliphatic hydrocarbon group containing 3 to 8 atoms. Examples of cycloalkyl groups include cyclopropyl, cyclopentyl and cyclohexyl. "Effective amount" or "therapeutically effective amount" means an amount of at least one compound for formula I, or a pharmaceutical^ acceptable salt thereof, that significantly inhibits proliferation of tumor cells, including human tumor cell lines. "Halogen" means fluorine, chlorine, bromine or iodine, preferably chlorine, fluorine or bromine. "Hetero atom" means an atom selected from N, O and S, preferably N. If the hetero atom is N, it can be present as -NH- or -N-lower alkyl-. If the hetero atom is S, it can be present as S, SO or S02. "Heteroaryl" means an aromatic heterocyclic ring system containing up to two rings. Preferred heteroaryl groups include, but are not limited to, thienyl, furyl, indolyl, pyrrolyl, pyridinyl, pyrazinyl, oxazolyl, thiaxolyl, quinolinyl, pyrimidinyl, imidazole and tetrazolyl. "Heterocycle" or "heterocyclyl" means a 3- to 10-membered saturated or partially unsaturated non-aromatic monovalent cyclic radical having from one to 3 hetero atoms selected from nitrogen, oxygen or sulfur or a combination thereof. Examples of preferred heterocycles are piperidine, piperazine, pyrrolidine, and morpholine. "Hydroxy" is a prefix indicating the presence of a monovalent OH group. "IC50" refers to the concentration of a particular compound according to the invention required to inhibit 50% of a specific measured activity, IC50 can be measured, inter alia, as is described in Example 12, infra. "Pharmaceutically acceptable salt" refers to conventional acid-addition salts or base-addition salts that retain the biological effectiveness and properties of the compounds of formula I and are formed from suitable non-toxic organic or inorganic acids or organic or inorganic bases. Sample acid-addition salts include those derived from inorganic acids such as hydrochloric acid, hydrobromic acid, hydroiodic acid, sulfuric acid, sulfamic acid, phosphoric acid and nitric acid, and those derived from organic acids such as p-toluenesulfonic acid, salicylic acid, methanesulfonic acid, oxalic acid, succinic acid, citric acid, malic acid, lactic acid, fumaric acid, and the like. Sample base-addition salts include those derived from ammonium, potassium, sodium and, quaternary ammonium hydroxides, such as for example, tetramethylammonium hydroxide. The chemical modification of a pharmaceutical compound (i.e. drug) into a salt is a technique well known to pharmaceutical chemists to obtain improved physical and chemical stability, hygroscopicity, flowability and solubility of compounds. See, e.g., H. Ansel et. al, Pharmaceutical Dosage Forms and Drug Delivery Systems (6th Ed. 1995) at pp. 196 and 1456-1457. "Pharmaceutically acceptable," such as pharmaceutically acceptable carrier, excipient, etc., means pharmacologically acceptable and substantially non-toxic to the subject to which the particular compound is administered. "Substituted," as in substituted alkyl, means that the substitution can occur at one or more positions and, unless otherwise indicated, that the substituents at each substitution site are independently selected from the specified options. or a pharmaceutically acceptable salt thereof, wherein R1 is selected from the group H, C1-10alkyl, C1-10alkyl substituted by up to three groups selected from aryl, cycloalkyl, heteroaryl, heterocycle, NR10,R11, OR12, SR12, halogen, COR13, C02R13, CONRI3R14, S02NR13R14, SOR13, S02R13, CN and N02) wherein the aryl, cycloalkyl, heteroaryl, and heterocycle groups may each independently be substituted by up to three groups selected from NR10Rn, OR12, SR12, halogen, COR13, C02R13, CONR13R14, S02NRi3R14, SOR13, S02R13, CN and N02, aryl, aryl substituted by up to three groups selected from lower alkyl, NR10RH, OR12, SR12, halogen, COR13, C02R13, CONR13R14, S02NR13RM, SOR13, S02R13, CN and N02, heteroaryl, heteroaryl substituted by up to three groups selected from lower alkyl, NRI0Rn, OR12, SR12, halogen, COR13, C02R13, CONR13R14, S02NR13R14, SOR13, S02R13, CN and N02, heterocycle, heterocycle substituted by up to three groups selected from lower alkyl, NR R , OR12, SR12, halogen, COR13, C02R13, C0NR13R14, S02NR13R14, SOR13, S02R13, CN and N02> C3-10 cycloalkyl, C3-10 cycloalkyl substituted by up to three groups selected from lower alkyl, NR10RU, OR12, SR12, halogen, COR13, C02R13, CONRI3R14, S02NR13R14, SOR13, S02R13, CN and N02, C2-10 alkenyl, C2-10 alkenyl substituted by up to three groups selected from NR R , OR ", SR , halogen, COR13, C02R13, CONR13R14, S02NR13R14, SOR13, S02R13, CN and N02) and C2.10 alkynyl, substituted by up to three groups selected from NR R , OR , SR ", halogen, COR13, C02R13, CONR13R14, S02NR13R14, SOR13, S02R13, CN and N02; R , R and R are independently selected from the group consisting of H, NR10R11, OR12, SR12, C1-10 alkyl, C1-10 alkyl substituted by up to three groups selected from cycloalkyl, heteroaryl, heterocycle, NR10RU, OR12, SR12, halogen, COR13, C02R13, CONR13R14, S02NR13R14, SOR13, S02R13, CN and N02; and wherein the cycloalkyl, heteroaryl, and heterocycle groups may each independently be substituted by up to three groups selected from lower alkyl, NR10R11, OR12, SR12, halogen, COR13, C02R13, CONR13R14, S02NR13R14, SOR13, S02R13, CN and N02, heteroaryl, heteroaryl substituted by up to three groups selected from lower alkyl, NR10R11, OR12, SR12, halogen, COR13, C02R13, CONR13R14, S02NR13R14, SOR13, S02R13, CNandN02, heterocycle, substituted by up to three groups selected from lower alkyl, NR10R11, OR12, SR12, halogen, COR13, C02R13, CONR13R14, S02NR13R14, SOR13, S02R13, CN and N02, C3.10 cycloalkyl, C3-10 cycloalkyl substituted by up to three groups selected from lower alkyl, NR10R", OR12, SR12, halogen, COR13, C02R13, CONR13R14, S02NR13R14, SOR13, S02R13, CNandN02, C2-10alkenyl, C2-10 alkenyl substituted by up to three groups selected from NR R , OR , SR , halogen, COR13, C02R13, CONR13R14, S02NR13R14, SOR13, S02RB, CN and N02, C2-10alkynyl, and C2-10 alkynyl substituted by up to three groups selected from NR R , OR12,, SR12, halogen, COR13, C02R13, CONR13Rl\ S02NRi3R14, SOR13, S02R13, CN and N02, provided that at least one of R2, R3 or R4 is not H; COR13, C02Rl3, CONR13R14, S02R13, S02NR13R14, lower alkyl, lower alkyl substituted by hydroxy, alkoxy or NR15R16, cycloalkyl, cycloalkyl substituted by hydroxy, alkoxy, lower alkyl, or NRI5R16, heterocycle, and heterocycle substituted by hydroxy, alkoxy, lower alkyl, or NR15R16, or, alternatively, NR1 R11 can form a ring having 3 to 7 atoms, said ring optionally including one or more additional hetero atoms and being optionally substituted by the group consisting of one or more lower alkyl, OR12, COR13, C02R13, CONRI3R14, SOR13, S02Ri3, and S02NR13R14; 12 R is selected from the group H, lower alkyl, COR13, CONR13R14, C2-6 alkyl substituted by hydroxy, alkoxy, or NRI5R16, cycloalkyl, cycloakyl substituted by hydroxy, alkoxy, lower alkyl, or NRl5R! , heterocycle, and heterocycle substituted by hydroxy, alkoxy, lower alkyl, or NR 15R 16 R13 and R14 are independently selected from the group H, lower alkyl, C2-6 alkyl substituted by hydroxy, alkoxy, or NR15R16, cycloalkyl, cycloalkyl substituted by hydroxy, alkoxy, lower alkyl, or NR15R16, heterocycle, and heterocycle substituted by hydroxy, alkoxy, lower alkyl, or NRl5R16, or , alternatively, NR R can form a ring having 3 to 7 atoms, said ring optionally including one or more additional hetero atoms and being optionally substituted by the group consisting of one or more lower alkyl, OR17, COR17, C02RI7, CONR17R18, S02R17, and S02NR17R18; R15 is selected from the group H, lower alkyl, COR17, and C02R17; and R16, R17 and R18 are independently selected from the group H, and lower alkyl, or, alternatively, NR15R16 and NR17R18 can each independently form a ring having 3 to 7 atoms, said ring optionally including one or more additional hetero atoms; R19 and R20 are independently selected from the group H, and lower alkyl; and R21 is selected from lower alkyl, and C2-6 alkyl substituted by hydroxy, alkoxy or NRl5R16. Compounds disclosed herein and covered by formula I above may exhibit tautomerism or structural isomerism. It is intended that the invention encompasses any tautomeric or structural isomeric form of these compounds, or mixtures of such forms (e.g. racemic mixtures), and is not limited to any one tautomeric or structural isomeric form depicted in formula I above. In a preferred embodiment, the invention relates to a compound of formula I wherein R1 is selected from aryl, and aryl substituted by CN or CONR R . Especially preferred are those compounds, wherein aryl is phenyl. In another preferred embodiment of the compounds of formula I, R is selected from lower alkyl and C2-6 alkyl substituted by OR12 or CONR13R14. Especially preferred are those compounds, wherein R is lower alkyl. In another preferred embodiment of the compounds of formula I, R and R are each independently selected from C1-100 alkyl and C1-10 alkyl substituted by OR or NR10R11. In another preferred embodiment of the compounds of formula I, R is OK.12 In a further preferred embodiment of the compounds of formula I, R is H. In another preferred embodiment of the compounds of formula I, R and R are H. In another preferred embodiment of the compounds of formula I, R4 is C1-10 alkyl substituted by NR10R11. In another preferred embodiment of the compounds of formula I, R5, R6 and R8 are H and R7 is O-lower alkyl, preferably 0-CH3. In another preferred embodiment of the compounds of formula I, R5 is halogen, preferably Br. In another preferred embodiment of the compounds of formula I, R9 is H. The following compounds are preferred embodiments according to the present invention: (±)-3-[7-[3-(2-hydroxy-ethyl)-phenylamino]-3-(4-methoxy-phenyl)-4-methyl-2-oxo-3J4-dihydro~2H-pyrimido[4)5-d]pyrimidin-l-yl]-benzonitrile (Example 4); (±)-3-[7-[3-(2-diethylamino-ethyl)-phenylamino]-3-(4-methoxy-phenyl)-4-methyl-2-oxo-3,4-dihydro-2H-pyrimido[4)5-d]pyrimidin-l-yl]-benzonitrile (Example 5b); (±)-3-[7-[3-(2-dimethylamino-ethyl)-phenylamino]-3-(4-methoxy-phenyl)-4-methyl-2-oxo-3,4-dihydro-2H-pyrimido[4,5-d]pyrimidin-l-yl]-benzonitrile (Example 6); (±)-3-(3-(4-methoxy~phenyl)-4-methyl-7-(3-[2-(4-methyl-piperazin-l-yl)-ethyl]-phenylamino}-2-oxo-3)4-dihydro-2H-pyrimido[4)5-d]pyrimidin-l-yl)-benzonitrile (Example 7); (±)-3-[7-[3-(2-diethylamino-ethyl)-phenylamino]-3-(4-methoxy-phenyl)-4-methyl-2-oxo-3)4-dihydro-2H-pyrimido[4>5-d]pyrimidin-l-yl]-benzamide (Example 8); (±)-3-[7-[3-(2-dimethylamino-ethyl)-phenylamino]-3~(4-methoxy-phenyl)-4-methyl-2-oxo-3)4-dihydro-2H-pyrimido[4)5-d]pyrimidin-l-yl]-benzamide (Example 9); (±)-3-(3-(4-methoxy-phenyl)-4-methyl-7-{3-[2-(4-methyl-piperazin-l-yl)-ethyl]-phenylammo}-2-oxo-3>4~dihydro-2H-pyrimido[4J5-d]pyrimidin-l-yl)-benzamide (Example 10); 3-(2-bromo-phenyl)-7-[4-(2-diethylamino-ethoxy)-phenylamino]-l,4-dimethyl-3,4-dihydro-lH-pyrimido[4,5-d]pyrimidin-2-one (enantiomer 1) Example 1 If); 3-(2-bromo-phenyl)~7-[4-(2-diethylamino-ethox)r)-phenylamino]-l)4-dimethyl-354-dihydro-lH-pyrimido[4,5-d]pyrimidin-2-one (enantiomer 2) Example llg ); and (±)-(3-(2-Bromo-phenyl)-7-[4-(2-diethylamino-ethoxy)-phenylamino]-l,4-dimethyl-3)4-dihydro-lH-pyrimido[4,5-d]pyrimidin-2-one. The compounds of the invention inhibit Src tyrosine kinases. These compounds are useful in the treatment or control of cancer, in particular the treatment or control of solid tumors, specifically breast, colon, hepatic and pancreatic tumors. These compounds are highly permeable to cell membranes and thus possess advantageous bioavailability profiles such as improved oral bioavailability. In an alternative embodiment, the present invention relates to pharmaceutical compositions comprising at least one compound of formula I, or a pharmaceutical^ acceptable salt or ester thereof. These pharmaceutical compositions can be administered orally, for example in the form of tablets, coated tablets, dragees, hard or soft gelatin capsules, solutions, emulsions or suspensions. They can also be administered rectally, for example, in the form of suppositories, or parenterally, for example, in the form of injection solutions. The pharmaceutical compositions of the present invention comprising compounds of formula I, and/or the salts thereof, may be manufactured in a manner that is known in the art, e.g. by means of conventional mixing, encapsulating, dissolving, granulating, emulsifying, entrapping, dragee-making, or lyophilizing processes. These pharmaceutical preparations can be formulated with therapeutically inert, inorganic or organic carriers. Lactose, corn starch or derivatives thereof, talc, steric acid or its salts can be used as such carriers for tablets, coated tablets, dragees and hard gelatin capsules. Suitable carriers for soft gelatin capsules include vegetable oils, waxes and fats. Depending on the nature of the active substance, no carriers are generally required in the case of soft gelatin capsules. Suitable carriers for the manufacture of solutions and syrups are water, polyols, saccharose, invert sugar and glucose. Suitable carriers for injection are water, alcohols, polyols, glycerine, vegetable oils, phospholipids and surfactants. Suitable carriers for suppositories are natural or hardened oils, waxes, fats and semi-liquid polyols. The pharmaceutical preparations can also contain preserving agents, solubilizing agents, stabilizing agents, wetting agents, emulsifying agents, sweetening agents, coloring agents, flavoring agents, salts for varying the osmotic pressure, buffers, coating agents or antioxidants. They can also contain other therapeutically valuable substances, including additional active ingredients other than those of formula I. The present invention is further directed to the use of a compound of formula I for treating cancer, in particular breast, colon, hepatic and pancreatic cancer, by administering to a human patient in need of such therapy an effective amount of a compound of formula I and/or its salt. As mentioned above, the compounds of the present invention, including the compounds of formula I, are useful in the treatment or control of cell proliferative disorders, in particular oncological disorders. These compounds and formulations containing said compounds are particularly useful in the treatment or control of solid tumors, such as, for example, breast, colon, hepatic and pancreatic tumors. Thus, the present invention is further directed to a method for treating such solid tumors by administering to a patient in need of such therapy an effective amount of a compound of formula I and/or its salt. A therapeutically effective amount of a compound in accordance with this invention means an amount of compound that is effective to prevent, alleviate or ameliorate symptoms of disease or prolong the survival of the subject being treated. Determination of a therapeutically effective amount is within the skill in the art. The therapeutically effective amount or dosage of a compound according to this invention can vary within wide limits and may be determined in a manner known in the art. Such dosage will be adjusted to the individual requirements in each particular case including the specific compound(s) being administered, the route of administration, the condition being treated, as well as the patient being treated. In general, in the case of oral or parenteral administration to adult humans weighing approximately 70 kg, a daily dosage of about 10 mg to about 10,000 mg, preferably from about 200 mg to about 1,000 mg, should be appropriate, although the upper limit may be exceeded when indicated. The daily dosage can be administered as a single dose or in divided doses, or for parenteral administration, it maybe given as continuous infusion. In another embodiment, the invention is directed to a process for the preparation of a compound of formula I of claim 1, which process comprises wherein R is H, and if desired, b) reacting the compound of formula lb with an acid halide or anhydride to obtain P19 R20 O R \ P O II \/ II 21 a compound of formula I, wherein R9 is C—O-C—O-C—R or COR17, and wherein R17, R19, R20 and R21 are as defined in claim L and/or c) if desired, converting the compound of formula I into a pharmaceutical^ acceptable salt. The present invention is also directed to the following novel intermediates useful in the synthesis of compounds of formula I: (±)-acetic acid 2-{3-[8~(3-cyano-phenyl)-6-(4-methoxy-phenyl)-5-methyl-7-oxo- 5,6>7,8-tetrahydro-pyrimido[4,5-d]pyrimidin-2-ylamino]-phenyl}-ethyl ester (Example 3c); and , (±)-methanesulfonic acid (2-{3-[8-(3-cyano-phenyl)-6-(4-methox)r-phenyl)-5-methyl-7-0X0-5,6,7,8~tetrahydro-pyrimido[4j5-d]pyrimidin-2-ylamino] -phenyl} -ethyl) -ester (Example 5a). Examples The following examples illustrate preferred methods for synthesizing the compounds and formulations of the present invention. Example 1 Example la (±)-l-(2,4-Dichloro-pyrimidin-5-yl)-ethanol was synthesized from 2,4-dichloropyrimidine (Aldrich) according to the literature procedure of Pie, N.; Turck, A.; Martin, P.; Barbey, S.; Queguiner, G. Tet. Lett, 1993 (34), 1605-1608. Example lb To a solution of (±)-l-(2,4-dichloro-pyrimidin-5-yl)-ethanol (1.27 g, 6.60 mmol) (from Example la supra) in phosphorus oxychloride (5.0 mL, 53.11 mmol) (Aldrich), at 0 °C, was added diisopropylethyl-amine (2.60 mL, 14.78 mmol) (Aldrich). The reaction was stirred at 0 °C for 5 minutes, at ambient temperature for 15 minutes and then at 115 °C for 3 hours. The reaction was cooled to room temperature, diluted with toluene (10 mL) and the mixture was then poured into ice (15 g). After stirring for 10 minutes, the layers were separated and the aqueous extract was back washed with toluene. The combined organic extracts were dried over anhydrous sodium sulfate, filtered, and concentrated. Purification by flash chromatography (Biotage, 40M, 10:90 to 15:85 ethyl acetate - hexanes gradient) gave (±)-2,.4-dichloro~5-(l-chloroethyl)-pyrimidine as an oil. (Yield 1.233 g; 88.3%). Example lc (±)-2,4-Dichloro-5-(l-bromoethyl)-pyrirnidine 255.93 A solution of (±)-l-(2,4-dichloro-pyrimidin-5~yl)-ethanol (0.50 g; 2.60 mmol) (from Example la supra) and diisopropylethylamine (1.10 mL; 6.25 mmol) (Aldrich) in dibromomethane (0.35 mL) was cooled to 15 °C. Phosphorus oxybromide (0.73 g; 2.83 mmol) was added in one portion. Cooling bath was removed and reaction mixture was stirred at room temperature. After 20 minutes, the reaction was diluted with ethyl acetate and water. The organic phase was washed with brine and then dried over anhydrous sodium sulfate, filtered and concentrated to give crude (±)-2,4-dichloro~5-(l-bromoethyl)-pyrimidine (0.61 g; 91.4%). Purification by flash chromatography (Biotage, 40M, 10:90 ethyl acetate - hexanes) gave pure (±)-2,4-dichloro-5-(l-bromoethyl)-pyrimidine as an oil which solidified when stored in refrigerator. Alternatively, (±)-2,4-dichloro-5-(l-bromoethyl)-pyrimidine was prepared as follows. Ethyl 2-formylbutyrate HO A solution of diisopropylamine (120.6 mL, 0.86 mol) (Aldrich) in tetrahyrofuran (370 mL) was cooled to -30 °C. n-Butyllithium (2.5 M in hexanes, 344.2 mL, 0.86 mol) (Aldrich) was added drop wise at such a rate that the reaction mixture temperature was kept between -30 to 0 °C. The reaction mixture was then cooled to -75 °C in a dry ice -acetone bath. A solution of ethyl butyrate (100 g, 0.86 mol) (Aldrich) in tetrahydrofuran (170 mL) was added drop wise over 28 minutes and keeping the reaction temperature between -75 to -70 °C. The mixture was stirred at the same temperature for an additional 30 minutes. Ethyl formate (125 mL, 1.55 mol) (Aldrich) was then ad'ded to this mixture over 25 minutes and maintaining the temperature between -75 to -70 °C. The resultant mixture was allowed to warm to room temperature and stirred at room temperature for 3 hours. With external cooling in a cold water bath to keep the reaction temperature below 30 °C acetic acid (98.55 mL,1.72 mol) was added, followed by water (430 mL) and dichloromethane (200 mL). After separating the layers, the organic layer was washed with water (300 mL). The combined water layer Was extracted with dichloromethane (200 mL). The combined organic layer was washed with aqueous sodium bicarbonate solution (200 mL). The basic aqueous solution was extracted with dichloromethane (100 mL). All organic layers were then combined, dried over sodium sulfate over night, filtered and distilled to remove solvent leaving about 180 mL. (Some of the product was distilled over with tetrahydrofuran.) The residue was distilled at 65 -81 °C (23 mm Hg). The fraction distilling over at 70 - 81 °C (23 mm Hg) gave ethyl 2-formylbutyrate. (Yield 68.35 g, 55.1%). 5-Ethyl uracil Urea (19.39 g, 0.32 mol) (J. T. Baker) was added over 20 minutes to fuming sulfuric acid (26 - 29.5% free SO3, 135 mL, 2.65 mol) (Aldrich) with cooling in an ice water bath maintaining the reaction temperature between 8 to 15 °C. After stirring for an additional 30 minutes, ethyl 2-formylbutyrate (46.55 g, 0.32 mol) (from Example lc, supra) was added over 18 minutes keeping the reaction at the same temperature. After stirring for another 30 minutes, a second portion of urea (15.07 g, 0.25 mol) was added over 10 minutes at the same temperature. The reaction mixture was then stirred at room temperature for 65 hours, and at 90 - 100 °C for 2 hours (gas evolution was observed, and reaction was exothermic, with reaction temperature rising to 110 °C). The mixture was cooled to 30 °C with an ice - water bath. Ice (270 g) was added slowly keeping the reaction below 35 °C. The mixture was then cooled to 5 °C and stirred for 20 minutes. The solid formed was collected by filtration, washed with cold water, hexanes, and diethyl ether and dried by suction to give 5-ethyl uracil. (Yield 38.85 g, 85.9%). 2,4-Dichloro-5-ethylpyrimidine N,N-Diisopropylethylamine (195 mL, 0.86 mol) (Aldrich) was added slowly to a mixture of 5-ethyl uracil (52.3 g, 0.37 mol) (from Example lc, supra) and phosphorous oxychloride (150 mL, 1.61 mol) (Aldrich) with external cooling in a cold water bath. The mixture was heated at reflux for 3.8 hours and cooled to room temperature. Mixture was then poured into ice (300 g). Ethyl acetate (100 mL) was added and mixture stirred at 20 °C for 30 minutes with cooling in an ice - water bath. The resulting mixture was filtered through Celite® and the filtrate extracted with ethyl acetate - hexanes (1:1, 3 X 300 mL). The combined organic layers was washed with water (250 mL), dried over sodium sulfate, filtered and concentrated to dryness. This residue was dissolved in ethyl acetate -hexanes (1:1) and filtered through TLC grade silica gel and eluting with the same solvent. The filtrate was concentrated to dryness to give 2,4-dichloro-5-ethyl-pyrimidine. (Yield 56.3 g, 85.2%). N-Bromosuccimimide (64.2 g, 0.35 mol) (Aldrich) and 2,2-azo-bis-isobutyronitrile (AIBN, 1.78 g) (Aldrich) were added to a solution of 2,4-dichloro-5-ethylpyrimidine (56.3 g, 0.32 mol) (from Example lc, supra) in carbon tetrachloride (400 mL). The mixture was heated at reflux for 1.5 hours and cooled to room temperature. Reaction mixture was filtered through TLC grade silica gel and eluted with ethyl acetate -hexanes (1:8). The filtrate was concentrated to dryness to give (±)-2,4-dichloro-5-(l-bromoethyl)-pyrimidine. (Yield 81.3 g, 100%). Example Id (±)-2,4-Dichloro-5-(l-bromoethyl)-pyrimidine (1.97 g; 7.70 mmol) (from Example lc supra) was dissolved in acetonitrile (21 mL). p-Anisidine (0.95 g; 7.70 mmol) (Aldrich), potassium carbonate (1.17 g; 8.48 mmol) and potassium iodide (0.32 g; 1.93 mmol) were added and the mixture was stirred at room temperature. After 16 hours, the mixture was partitioned between ethyl acetate and water. The organic phase was washed writh water and brine, dried over anhydrous sodium sulfate, filtered and concentrated. Purification by flash chromatography (Biotage 40M, 20:80 to 25:75 ethyl acetate- hexanes gradient) gave (±)-[l-(2,4-dichloro-pyrimidin-5-yI)-ethyl]-(4-methoxy-phenyl)-amine. (Yield 1.82 g; 76.3%). Example 2 (±)-3-[7-Chloro-3-(4-methoxy-phenyl)-4-methyl-2-oxo-3)4-dihydro-2H-pyrimido[4>5-d]pyrimidin-l-yl]-benzonitrile To a solution of (±)-[l-(2)4-dicUoro~pyrimidin-5-yl)-ethyl]-(4-methoxy-phenyl)-amine (0.10 g; 0.34 mmol) (from Example Id supra) in toluene (1 mL) was added 3-cyanophenyl isocyanate (66.6 mg; 0.46 mmol) (Aldrich). The mixture was heated in an oil bath at 110 °C for two hours. After cooling to room temperature, the reaction was concentrated under reduced pressure. The residue was triturated with hexanes and dried briefly. The solid residue (intermediate urea) was taken up in freshly distilled tetrahydrofuran (1.5 mL), cooled in an ice - brine bath and treated with potassium tert-butoxide (1.0 M in tetrahydrofuran; 370 pi; 037 mmol) (Aldrich). After 15 minutes in the cold the reaction was complete by TLC analysis and was filtered through a silica gel pad (0.5 g) and washed with ethyl acetate. The filtrate was concentrated and the residue was purified by flash chromatography (Biotage, 12M, 40:60 ethyl acetate - hexanes) to give (±)-3-[7-chloro-3-(4-methoxy-phenyl)-4-methyl-2-oxo-3,4-dihydro-2H-pyrimido[4,5-d]pyrimidin-l-yl]-benzonitrile as a solid. (Yield 0.13 g; 85.6%). Example 3a 3-Nitrophenethyl alcohol (55 g, 0.33 mol) (Aldrich) was dissolved in pyridine (1.2 L) (Aldrich). Acetic anhydride (215 mL, 2.14 mol) (Aldrich) was added slowly, and the mixture was stirred overnight at room temperature (TLC: 30% ethyl acetate in Hexanes showed complete conversion). Ice and water (200 mL) were poured into the reaction mixture. The mixture was diluted with ethyl acetate, then successively washed with aqueous IN hydrochloric acid (pH = -1), water, and brine. The organic layer was dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to give acetic acid 2-(3-nitro-phenyl)-ethyl ester as a yellow oil. (Yield 58.86 g, 0.28 mol, 85%). Example 3b To a solution of acetic acid 2-(3-nitro-phenyl)-ethyl ester (15 g, 7L7 mmol) (from Example 3a supra) in ethyl acetate (150 mL), was added 10% palladium on carbon (1.5 g) (Aldrich). This mixture was hydrogenated at room temperature on the Parr apparatus at 50 psi for one hour. The reaction mixture was filtered over a bed of Celite® and washed with ethyl acetate. The filtrate was concentrated under reduced pressure to give acetic acid 2-(3-amino-phenyl)-ethyl ester. (Yield 12.81 g, 71.48 mmol, 99%). Example 3c (±)-Acetic acid 2-{3-[8-(3-cyano-phenyl)-6-(4-methoxy-phenyl)-5-methyl-7-oxo-5,6>7,8-tetrahydro-pyrimido[4)5-d]pyrimidin-2-ylamino]-phenyl}-ethyl ester A mixture of (±)-3-[7-chloro-3-(4-methoxy-phenyl)-4-methyl-2-oxo-3,4-dihydro-2H~pyrimido[4,5-d]pyrimidin-l-yl]-benzonitrile (1.00 g; 2.42 mmol) (from Example 2 supra) and acetic acid 2-(3-amino-phenyl)-ethyl ester (2.03 g; 11.3 mmol) (from Example 3b supra) was heated in an oil bath at 110 °C for 1.5 hours. Upon cooling, the mixture was triturated with hexanes containing a small volume of ethyl acetate. The supernatant was decanted away and the residue was purified, in two runs, by flash chromatography (Biotage 40M; 50:50 to 70:30 ethyl acetate - hexanes gradient). The purified material was crystallized from ethyl acetate - hexanes to give (±)-acetic acid 2-{3-[8-(3-cyano-phenyl)-6-(4-methoxy-phenyl)-5-methyl-7-oxo-5,6)7,8-tetrahydro- pyrimido[4,5-d]pyrimidin-2-ylamino]-phenyl}-ethyl ester as a white solid. (1.03 g; 77.5%). Melting Point: 170 - 172 °C. Example 4 Acetic acid (±)-2-{3-[8-(3-cyano-phenyl)-6-(4-methoxy-phenyl)-5-methyl-7-oxo-5>6>7J8-tetrahydro-pyrimido[4J5-d]pyrimidin-2-ylamino]-phenyl}-ethyl ester (1 0 g; 1.81 mmol) (from Example 3c supra) was dissolved in a mixture of methanol (17 mL) and water (7 mL) and treated with potassium carbonate (1.00 g; 7.26 mmol) at room temperature for 19 hours. The reaction mixture was partitioned between ethyl acetate and water - brine mixture. The organic phase was washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated. The crude material was purified by flash chromatography (Biotage 40M; ethyl acetate) to give (±)-3-[7-[3-(2-hydroxy-ethyl)-phenylamino]-3-(4-methoxy-phenyl)-4-methyl-2-oxo-3>4-dihydro-2H-pyrimido[4>5-d]pyrimidin-l-yl]-benzonitrile. (Yield 0.67 g; 72.9%). A small amount of additional material bumped over into the solvent trap during concentration. This material was recovered and crystallized from ethyl acetate. (Yield 0.09 g; 9.9%). Melting Point: 195 - 200°C. HR-MS(ES+) m/z Calculated for C29H26N603 ([M+Hf): 507.2139; Found: 507.2145. HR-MS(ES+) m/z Calculated for C29H26N603 ([M+Na]+): 529.9158; Found: 529.1963. Example 5 a (±)-Methanesulfonic acid (2-{3-[8-(3-cyano-phenyl)-6-(4-methoxy-phenyl)-5-methyl-7-oxo-5,6,7,8-tetrahydro-pyriniido[4,5-d]pyrimidin-2-ylamino] -phenyl} -ethyl) -ester (±)-3-[7-[3-(2-Hydroxy-ethyl)-phenylamino]-3-(4-methoxy-phenyl)-4-methyl-2-oxo-3,4-dihydro-2H-pyrimido[4)5-d]pyrimidin-l-yl]-benzonitrile (0.67 mg; 1.27 mmol) (from Example 4 supra) was suspended in dichloromethane (13 mL). The mixture was treated with triethylamine (0.23 mL; 1.65 mmol) and methane-sulfonyl chloride (0.13 mL; 1.68 mmol) (Aldrich). The solid went into solution as the methanesulfonyl chloride was added. After 45 minutes, the reaction was shown by thin layer chromatography to be complete. The reaction was diluted with additional dichloromethane and washed with water and then brine. The organic phase was dried over anhydrous sodium sulfate, concentrated and dried under high vacuum to give crude (±)-methanesulfonic acid (2-{3-[8-(3-cyano-phenyl)-6-(4-methoxy-phenyl)~5-methyl-7-oxo-5,6)7>8-tetrahydro-pyrimido[4,5-d]pyrimidin-2-ylamino]-phenyl) -ethyl)-ester as a foam. This material was used in the next step without further purification. (Yield:0.76 g, 95.4%). Example 5b (±)-3-[7-[3-(2-Diethylamino~ethyl)-phenylamino]-3~(4-methox);'-phenyl)-4-methyl-2-oxo-3,4-dihydro-2H-pyrimido[4,5-d]pyrimidin-l-yI]-benzonitrile A mixture of (±)-methanesulfonic acid (2-{3~[8-(3~cyano-phenyl)-6-(4-methoxy-phenyl)-5-methyl-7-oxo-5,6,7,8-tetrahydro-pyrimido[4,5-d]pyrimidin-2-ylamino]-phenyl}-ethyl)-ester (1.18 g; 2.02 mmol) (from Example 5a supra) and diethylamine (1.5 mL; 14.5 mmol) (Aldrich) in a pressure bottle and heated at 100 °C for 100 minutes. Upon cooling, the mixture was concentrated and the residue was partitioned between ethyl acetate and water. The organic phase was washed with brine, dried over anhydrous sodium sulfate and concentrated. Purification by flash chromatography (Biotage 40S; 100:0 to 50:50 ethyl acetate - methanol) followed by crystallization from ethyl acetate and hexanes gave (±)-3-[7-[3-(2-diethylamino-ethyl)-phenylamino]-3-(4-methoxy-phenyl)-4-methyl-2-oxo-3)4-dihydro-2H-pyrimido[4,5-d]pyrimidin-l-yl]-benzonitrile. (Yield 0.66 g; 57.9%). Melting Point: 128 - 145 °C. HR-MS(ES+) m/z Calculated for C33H35N702 ([M+H]+): 562.2925; Found: 562,2925. Example 6 (±)-3-[7-[3-(2-Dimethylamino-ethyl)-phenylamino]-3-(4-methoxy-phenyl)-4-methyl-2-oxo-3,4-dihydro-2H-pyrimido[4,5-d]pyrimidin-l-yl]-benzonitrile A mixture of (±)-methanesulfonic acid (2-{3-[8-(3-cyano-phenyl)-6-(4-methoxy-phenyl)-5-methyl-7-oxo-5,6,7,8-tetrahydro-pyrimido[4,5-d]pyrimidin-2-ylamino]-phenyl}-ethyl)-ester (0.19 g; 0.32 mmol) (from Example 5a supra) and dimethylamine (2.0 M in tetrahydrofuran; 2.00 mL; 4.00 mmol) (Aldrich) in a bomb bottle and heated at 100 °C overnight. Upon cooling, the mixture was concentrated and the residue was partitioned between ethyl acetate and water. The organic phase was washed with water and brine, dried over anhydrous sodium sulfate and concentrated. At this point, the crude material was combined with material from an earlier run and purified by flash chromatography (Biotage, 12S; 100:0 to 50:50 ethyl acetate - methanol). This material was then crystallized from ethyl acetate and ether to give (±)-3-[7-[3-(2-dimethylamino- ethyl)-phenylamino]-3-(4-methoxy-phenyl)-4-methyI-2-oxo-34-dihydro-2H-pyrimido[4,5-d]pyrimidin-l-yl]-benzonitrile as a solid. (Yield 0.12 g; 26.8%). Melting Point: 120 - 135 °C. HR-MS(ES+) m/z Calculated for C3lH3lN702 ([M+H]+): 534.2612; Found: 534.2619. Example 7 (±)-3-(3-(4-Methoxy-phenyl)-4-methyl-7-{3-[2-(4-methyl-piperazin-l-yl)-ethyl]-phenylamino}-2-oxo-3)4-dihydro-2H-pyrimido[4)5-d]pyrimidin-l-yl)-benzonitrile A mixture of (±)-methanesulfonic acid (2-{3-[8-(3-cyano-phenyl)-6-(4-methoxy-phenyl)-5-methyl-7-oxo-5)6)7,8-tetrahydro-pyrimido[4,5-d]pyrimidin-2-ylamino]-phenyl)-ethyl)-ester (0.10 g; 0.16 mmol) (from Example 5a supra) and 1-methylpiperazine (0.25 mL; 2.23 mmol) (Aldrich) and heated at 110 °C for 1 hour. Upon cooling, the mixture was diluted with ethyl acetate and washed with water and brine. The organic phase was dried over anhydrous sodium sulfate, filtered, and concentrated. The crude material was purified by flash chromatography (Biotage 12S; 100:0 to 40:60 ethyl acetate - methanol gradient) and then crystallized from ethyl acetate - hexanes to give (±)-3-(3-(4-methoxy-phenyl)-4~methyl-7-{3-[2-(4-methyl-piperazin-l-yl)-ethyl]-phenylamino}-2-oxo-3,4-dihydro-2H"pyrimido[4,5-d]pyrimidin-l-yl)-benzonitrile. (Yield 60.6 mg; 64.1%). Melting Point: 134- 155 °C HR-MS(ES+) m/z Calculated for C34H36N8O2 ([M+H]+): 589.3034; Found: 589.3041. Example 8 (±)-3-[7-[3-(2-Diethylamino-ethyI)-phenylamino]-3-(4-methoxy-phenyl)-4:methyl-2-oxo-3,4-dihydro--2H-pyrimido[4J5-d]pyrimidin-l-yl]-benzamide (±)-3-[7-[3~(2-Diethylamino-ethyl)-phenylamino]-3-(4-methoxy-phenyl)-4-methyl-2-oxo-3,4-dihydro-2H--pyrimido[435--d]pyriinidin-l-yl]-ben2onitrile (0.35 g; 0.60 mmol) (from Example 5b supra) was dissolved in dimethyl sulfoxide (3.5 mL) and the resulting solution was cooled in an ice - water bath. Aqueous sodium hydroxide (1 M; 1.15 mL; 1.15 mmol) was added, resulting in the precipitation of thebenzonitrile. Aqueous hydrogen peroxide (30%; 195 (J.L; 1.91 mmol) was then added. The benzonitrile slowly went back into solution. After 3 hours, water was added to the reaction mixture. The product initially separated out as a gum which then solidified. The solid was collected, washed with water and dried. Recrystallization from dichloromethane - ether gave (±)-3-[7-[3-(2-diethylamino-ethyl)-phenylamino]-3-(4-methoxy-phenyl)-4-methyl-2-oxo-3,4-dihydro-2H-pyrimido[4J5-d]pyrimidin-l-yl]-benzamide. (Yield 0.30 g; 84.8%). Melting Point: 170 - 175 °C. HR-MS(ES+) m/z Calculated for C33H37N7O3 ([M+H]+): 580.3031; Found: 580.3032. IC50 0.0045 \M. Example 9 (±)-3-[7-[3-(2-Dimethylamino-ethyl)-phenylamino]-3-(4-methoxy-phenyl)-4-methyl-2-oxo-3,4-dihydro-2H-pyrimido[4,5-d]pyrimidin-l-yl]-benzamide (±)-3-[7-[3-(2-Dimethylamino-ethyl)-phenylamino]-3-(4-methoxy-phenyl)-4-methyl-2-oxo-3,4-dihydro-2H-pyrimido[4,5-d]pyrimidin-l-yl]-benzonitrile (92.7 mg; 0.17 mmol) (from Example 6 supra) was dissolved in dimethyl sulfoxide (1.0 mL) and the resulting solution was cooled in an ice - water bath. Aqueous sodium hydroxide (1M; 300 μL] 0.30 mmol) was added, resulting in the precipitation of the benzonitrile. Aqueous hydrogen peroxide (30%; 53 pL; 0.52 mmol) was then added. The benzonitrile went back into solution and the product then precipitate out of solution. After 4 hours, the reaction was diluted with water. The solid was collected, washed with water and dried. Recrystallization from dichloromethane - ether gave (±)-3-[7-[3-(2-dimethylamino-ethyl)-phenylamino]-3-(4-methoxy-phenyl)-4-methyl-2-oxo-3,4-dihydro-2H-pyrimido[4,5-d]pyrimidin-l-yl]-benzamide. (Yield 72.9 mg; 76.1%). Melting Point: 215 - 230°C. HR-MS(ES+) m/z Calculated for C31H33N7O3 ([M+H]+): 552.2718; Found: 552.2722. Example 10 (±)-3-(3-(4-Methoxy-phenyl)-4-methyl-7-{3-[2-(4-methyl"piperazin-l-yl)-ethylj-phenylamino}-2-oxo-3J4-dihydro-2H-pyrimido[4)5-d]pyrimidin-l-yl)-benzamide (±)-3-(3-(4-Methoxy-phenyl)~4-methyl-7-{3-[2-(4-methyl-piperazin~l-yl)-ethyl]-phenylamino}-2-oxo-3)4-dihydro-2H-pyrimido[4J5-d]pyrimidin-l-yl)-benzonitrile (0.25 g; 0.41 mmol) (from Example 7 supra) was dissolved in dimethyl sulfoxide (2.5 mL) and the resulting solution was cooled in an ice - water bath. Aqueous sodium hydroxide (1 M; 750 |iL; 0.75 mmol) was added, resulting in the precipitation of the benzonitrile. Aqueous hydrogen peroxide (30 %; 130 [μL; 1.27 mmol) was then added. The cooling bath was removed. The solid went back into solution and a new solid precipitated out. After 3 hours the reaction mixture was diluted with water. The solid was collected, washed with water and air-dried under the house vacuum. Purification by flash chromatography (Biotage 12S; 90:10 to 60:40 chloroform - methanol gradient) and then crystallization from methanol - ethyl acetate gave (±)-3-(3-(4~methoxy-phenyl)-4- methyI-7-{3-[2-(4-methyl-piperazin-l-yl)-ethyl]-phenylamino}-2-oxo-3,4-dihydro-2H-pyrimido[4,5-d]pyrimidin-l-yl)-benzamide as a white solid. (Yield 35.7 mg; 14.3%). A second crop was collected by addition of ether to the mother liquor. (Yield 87.8 mg; 35.1%). Melting Point: 243 - 251 °C. HR-MS(ES+) mlz Calculated for C34H38N803 ([M+H]+): 607.3140; Found: 6073144. Example 11 3-(2-Bromo-phenyl)-7-[4-(2-diethylamino-ethoxy)-phenylamino]-l,4-dimethyl-3,4-dihydro-lH-pyrimido[4,5-d]pyrimidin-2-one Example 11a l-(4-Methylamino-2-methylsulfanyl-pyrimidin-5-yl)-ethanol 1.5 g 4-Methylamino-2-methylsulfanyl-pyrimidine-5-carbaldehyde (prepared according to WO 00/24744) were dissolved in 30 mL THF. 14 mL of a 1.4 M solution of methyl magnesium bromide in ether were added drop-wise below 5 °C. After stirring for 1 hr at 0 °C, another 14 mL Grignard solution were added within 30 min. Stirring was continued for 30 min at 0 °C and finally at RT for 25 hrs. The mixture was quenched with saturated ammonium chloride solution and extracted with ethyl acetate. Yield: 1.57 g of crude title product. Example 1 lb [5-(l-Chloro-ethyl)-2-methylsulfanyl-pyrimidin-4-yl]-methyl-amine 0.25 g of the product from Example 1 la, supra,were dissolved in 10 mL chloroform and 0.30 g thionyl chloride were added drop-wise. The mixture was refluxed for 2 hrs and evaporated to yield 0.31 g of the title product as the hydrochloride 'salt Example 11C 5-[l~(2-Bromo-phenylamino)-ethyl)-2-methlsulfanyl-pyrimidin-4-yl-methyl-amine 0.25 g of the product from Example 1 lb, supra, and 34 mg sodium iodide in 10 mL acetonitrile were stirred for 15 min at RT. The resulting suspension was added drop-wise at RT to a mixture of 0.21 g 2-bromoaniline (Aldrich) and 0.33 g N-ethyl-di-isopropyl amine (Aldrich) in 5 mL acetonitrile. Stirring was continued for 16 hrs and the mixture was diluted with 20 mL water and extracted with dichloromethane. Chromatography on silica (eluent CHC13) yielded 158 mg of the title product. Example 11d 3-(2-Bromo-phenyl)-l,4-dimethyl-7-methylsulfanyl-3J4-dihydro-lH-pyrimido[4J5-d]pyrimidin-2-one (enantiomers 1 + 2) To 1.1g of the product from Example 11c, supra, in 10 mL dry DMF were added 0.236 g sodium hydride (95%) with cooling. After stirring for 20 min at RT, the mixture was cooled to 5 °C and treated in small portions with a total of 1.01 g carbonyldiimi-dazole (Aldrich). Stirring was continued at 5 °C for 30 min and at RT over night. Excess sodium hydride was then destroyed by addition of a small amount of water under cooling. The mixture was diluted with water, extracted with ethyl acetate and the combined organic phases evaporated. The crude product was chromatographed on a chiral phase Chiracel OD-CSP (commercial 20 |im material from Daicel, eluent heptane / iso-propanol 1:1) to yield 470 mg each of the separated enantiomers of the title product as pale yellow powders. The first eluting enantiomer is termed "enantiomer 1", and likewise the corresponding enantiomer of the chiral compounds derived from it in the following preparation examples are termed "enantiomer 1". The second eluting enantiomer is termed "enantiomer 2", and likewise the corresponding enantiomer of the chiral compounds derived from it in the following preparation examples are termed "enantiomer 2". Example 11e3-(2-Bromo-phenyl)-7-methanesulfonyl-l,4-dimethyl-3,4-dihydro-lH-pyrimido[4,5- d]pyrimidin-2-one; enantiomer 1 0.628 g meta-chloroperbenzoic acid (77%) (Aldrich) were dissolved in 50mL CH2CI,and this solution was dried by filtration over sodium sulfate. The dried MCPBA solution was added to a solution of 0.437 g of the enantiomer 1 from Example l1d, supra, in 20 mL CH2CL2 dropwise at RT and stirring was continued over night. Excess peracid was destroyed by washing with dilute sodium bisulfite solution. The organic phase was washed with aqueous sodium bicarbonate, dried, and evaporated. Chromatography over silica in ethyl acetate / heptane yielded 430 mg of the title product. Example llf 3-(2-Bromo-phenyl)-7-[4-(2-diethylamino-ethoxy)-phenylamino]-l,4-dimethyl-3,4-dihydro-lH-pyrimido[4,5-d]pyrimidin-2-one (enantiomer 1) 152 mg of 4~(2-diethylamino-ethoxy)aniline (prepared accoridng to Roharnann, Friedrich, Chem. Ber. (1939) 72: p.1333) in 1 mL dry NMP were treated with 0.43 mL of a 2M solution of HC1 in ether and stirred at RT for 30 min. 100 mg of the product of Example lie, supra, were added and the mixture was heated to 120 -130 °C for 16 hrs. The mixture was diluted with 10 mL water and adjusted to alkaline pH by addition of NaOH. Extraction with CH2CI2 and concentration of the organic phases gave a crude oil from which NMP and excess aniline were distilled off under high vacuum in the Kugelrohr oven. The residue was dissolved in 0.1 mL methanol and slowly diluted with 0.5 mL water. A fine precipitate formed, which was isolated by centrifiigation and eventually purified further by preparative HPLC-MS. Yield: 20 mg of the title product. Example llg 3-(2-Bromo-phenyl)-7-[4-(2~diethylamino-ethoxy)-phenylamino]-l,4-dimethyl-3,.4-dihydro-lH-pyrimido[4,5-d]pyrimidin-2-one (enantiomer 2) The title product was obtained analogously to the compound of Example lie and Example llf, supra, but starting from enantiomer 2 of the product of Example lid, supra. Antiproliferative Activity The antiproliferative activity of the compounds of the invention is demonstrated below in Example 12 . These activities indicate that the compounds of the present invention are useful in treating cancer, in particular solid tumors such as breast, colon, hepatic and pancreatic tumors, more particularly breast and colon tumors. Example 12 Kinase Assay The activity of the compounds according to this invention as inhibitors for the src-family tyrosine kinases was shown by using the following assay. SRC-Inhibitor-Assay Parameters: Reaction mixture: ATP 5 pM Peptide (Ro + Jal33-Ro) 10 pM Jal33-Ro 196 nM Ro 9,8 pM PT66 230 ng/mL Assay buffer: 4 mM MgCl2 2 mM TCEP 50 mM HEPES 0,l%Tween20 pH7,3 Enzyme: 2,5 U/mL Inhibitor: max. 25 jiM min. 0,42 nM Materials: Eu-labelled phosphotyrosine antibody: - for Lck Cisbio Mab PT66-K, - for Src EG&G Wallac PT66 Eu-W1024 (all commercially available). Peptides: NH2-A-E-E-ET-Y-G-E-F-E-A-K-K-K-K-CONH2, and Jal33-G-Aminocaprylic acid-A-E-E-ET-Y-G-E-F-E-A-K-K-K-K-CONH2, wherein Jal33 is LightCycler-Red 640-N-hydroxy succinimide ester™; whereby both peptides were synthesized by an optimized solid phase peptide synthesis protocol (Merrifield (1962) Fed. Proc. Fed. Amer. Soc Exp. Biol. 21, 412) on an Zinsser SMP350 peptide synthesizer. Shortly, the peptide was assembled on 160 mg (22/8 pmol scale) of a Rink-Linker modified polystyrene solid phase by repeatedly conjugating a twenty fold excess of aminoacids each protected by temporary piperidine labile Fmoc-and permanent acid labile tert- Bu- BOC- and O-tert-Bu-groups depending on the side chain function. The substrate sequence AEEEIYGEFEAKKKK was N-terminal additionally mounted with the spacer amino acids Aminocaprylic acid and Glycin. After cleavage of the N-terminal temporary protecting group the still attached and protected peptide was labeled with a 1.5 fold amount of LightCycler-Red 640-N-hydroxy succinimide ester (purchased from Roche Diagnostics GmbH) and triethylamine. After 3 hrs. the resin was washed with dimethylformamide and isopropanol until the eluates of the blue resin got colourless. The fully protected and labeled peptide was removed from the solid phase and released from the permanent protecting groups by treatment with a mixture of 80% trifluoracetic acid, 10% ethanedithiol, 5% thioanisol and 5% water. The substrate was finally isolated by a preparative reverse phase HPLC purification. The purification yielded 12.2 mg RP-HPLC single peak pure blue material (lyophilisate). The identity was proven by MALDI mass spectroscopy [2720.0]. Enzymes: Upstate Lck (p56c, active), Upstate Src (p60cSRC, partially purified) were purchased from UBI. Homogenous, time-resolved Fluorescence Assay: Reader: Perkin Elmer, Wallac Viktor 1420-040 multilabel counter; Liquid handling system: Beckman Coulter, Biomek 2000. ATP, Tween 20, HEPES were purchased from Roche Molecular Biochemicals, MgCl.2 and MnCl2 were purchased from Merck Eurolab, TCEP was purchased from Pierce, 384 Well low volume fluorescence plates was purchased from Falcon, Assay Description: At first the enzyme is pre-incubated for 15 min. at 15 °C in aqueous solution with corresponding amounts of inhibitors according to this invention. Then the phosphorylation reaction is started by adding a reaction mixture, containing ATP, Peptide and PT66, and subsequent shaking. The proceeding of this reaction is immediately monitored using time resolved fluorescence spectroscopy in a suitable well plate reader. The IC50-values can be obtained from the reaction rates by using a non-linear curve-fit (Excelfit). The results of the foregoing in vitro experiments, including the IC50 values, are set forth in Table 1 below. The compounds of the invention have IC50 values in the above-reported assay of less than 1.0 \iM. Example 13 *Compound A represents a compound of the invention. Manufacturing Procedure: 1. Mix Items 1, 2 and 3 in a suitable mixer for 15 minutes. 2. Granulate the powder mix from Step 1 with 20% Povidone K30 Solution (Item 4). 3. Dry the granulation from Step 2 at 50 °C. 4. Pass the granulation from Step 3 through a suitable milling equipment. 5. Add the Item 5 to the milled granulation Step 4 and mix for 3 minutes. 6. Compress the granulation from Step 5 on a suitable press. Example 14 Capsule Formulation *Compound A represents a compound of the invention. Manufacturing Procedure: .g — 1. Mix Items 1, 2 and 3 in a suitable mixer for 15 minutes. 2. Add Items 4 & 5 and mix for 3 minutes. 3. Fill into a suitable capsule. Example 15 * Compound A represents a compound of the invention. Manufacturing Procedure: 1. Dissolve item 1 in item 2. 2. Add items 3, 4 and 5 to item 6 and mix until dispersed, then homogenize. 3. Add the solution from step 1 to the mixture from step 2 and homogenize until the dispersion is translucent. 4. Sterile filter through a 0.2μm filter and fill into vials. Example 16 *Compound A represents a compound of the invention. Manufacturing Procedure: 1. Dissolve item 1 in item 2. 2. Add items 3, 4 and 5 to item 6 and mix until dispersed, then homogenize. 3. Add the solution from step 1 to the mixture from step 2 and homogenize until the dispersion is translucent. 4. Sterile filter through a 0.2 \μm filter and fill into vials. While the invention has been illustrated by reference to specific and preferred embodiments, those skilled in the art will understand that variations and modifications may be made through routine experimentation and practice of the invention. Thus, the invention is intended not to be limited by the foregoing description, but to be defined by the appended claims and their equivalents. i Claims or a pharmaceutically acceptable salt thereof, wherein R1 is selected from the group H, C1-10alkyl, C1-10 alkyl substituted by up to three groups selected from aryl, cycloalkyl, heteroaryl, heterocycle, NR10R11, OR12, SR12, halogen, COR13, C02R13, CONR13R14, S02NR!3R14, SOR13, S02R13, CN and N02, wherein the aryl, cycloalkyl, heteroaryl, and heterocycle groups may each independently be substituted by up to three groups selected from NR10Rn, OR12, SR12,, halogen, COR13, C02R13, CONR13R14, S02NR13R14, SOR13, S02R13, CN and N02, aryl, aryl substituted by up to three groups selected from lower alkyl, NR R , OR ~, SR12, halogen, COR13, C02R13, CONR13R14, S02NR13R14, SOR13, S02R13, CN and NO, heteroaryl, s heteroaryl substituted by up to three groups selected from lower alkyl, NR R >, OR12, SR12, halogen, COR13, C02R13, CONR13R14, S02NR13R14, SOR13, S02R13, CN and N02, heterocycle, heterocycle substituted by up to three groups selected from lower alkyl, NR10RU, OR12, SR12, halogen, COR13, C02R13, CONR13R14, S02NR13R14, SOR13, S02R13, CN and N02) C3-10 cycloalkyl, C3-10 cycloalkyl substituted by up to three groups selected from lower alkyl NR10RU, OR12, SR12, halogen, COR13, C02R13, CO2R13R14, S02NR13R14, SOR13, S02R13, CN and N02, C2-10 alkenyl, C2-10 alkenyl substituted by up to three groups selected from NR10RU, OR12, SR12, halogen, COR13, C02R13, CONR13R14, S02NR13R14, SOR13, S02R13, CN and N02) and C2-10 alkynyl, substituted by up to three groups selected from NR10Rn, OR12, SR12, halogen, COR13, C02R13, CONR13R14, S02NR13R14, SOR13, S02R13, CN and N02; R , R and R are independently selected from the group consisting of H, NRI0R11, OR12, SR12, C1-.10 alkyl, C1.10 alkyl substituted by up to three groups selected from cycloalkyl, heteroaryl, heterocycle, NR10R11, OR12, SR12, halogen, COR13, C02R13, CONR13R14, S02NR13R14, SOR13, S02R13, CN and N02; and wherein the cycloalkyl, heteroaryl, and heterocycle groups may each independently be substituted by up to three groups selected from lower alkyl, NR10Rn, OR12, SR12, halogen, COR113, C02R13, CONR13R14, S02NR13RM, SOR13, S02R13, CN and N02, heteroaryl, heteroaryl substituted by up to three groups selected from lower alkyl, NR10RU, OR12, SR12, halogen, COR13, C02R13, CONR13R14, S02NR13R14, SOR13, S02R13, CN and N02, heterocycle, substituted by up to three groups selected from lower alkyl, NR R11, OR12, SR12, halogen, COR13, C02R13, C0NR13R14, S02NR13R14., SOR13, S02R13, CN andN02, C3-10 cycloalkyl, C3-10 cycloalkyl substituted by up to three groups selected from lower alkyl, NR10R11, OR12, SR12 , halogen, COR13, C02R13, CONR13R14, S02NRl3R14, SOR13, S02RI3,CNandN02, C2-ioalkenyl> C2_io alkenyl substituted by up to three groups selected from NR10RU, OR1 , SR , halogen, COR13, C02R13, C0NR13R14, S02NR13R14, SOR13, S02R13, CN and N02, C2-10alkynyl, and C2-10 alkynyl substituted by up to three groups selected from NR10RLl, OR12, SR12, halogen, COR13, C02R13, CONR13R14, S02NRI3R14, SOR13, S02R13, CN and N02, O 1 A provided that at least one ofR2,R3,orR4is not H; R5, R6, R7 and R8 are independently selected from the group H, lower alkyl, lower alkyl substituted by hydroxy-or alkoxy, NR15R16, OH, OR17, SR17, halogen, COR17, C02R17, CONR17R18, S02NR17R18, SOR17, S02R17, and CN; R is selected from the group H, D19 R20 o R \ f5 o II \/ II 21 -C-0-C-0-C-R21)and COR17; R and R are independently selected from the group H, COR13, C02R13, C0NR13R14, S02R13, S02NR13R14, lower alkyl, lower alkyl substituted by hydroxy, alkoxy or NR15R16, cycloalkyl, cycloalkyl substituted by hydroxy, alkoxy, lower alkyl, or NR15R 6, heterocycle, and heterocycle substituted by hydroxy, alkoxy, lower alkyl, or NR R , or, alternatively, NRl0R11 can form a ring having 3 to 7 atoms, said ring optionally including one or more additional hetero atoms and being optionally substituted by the group consisting of one or more lower alkyl, OR12, COR13, C02R13, CONR13RM, SOR13, S02R13, and S02NR13R14; R is selected from the group H, lower alkyl, COR13, CONR13R14, C2-6 alkyl substituted by hydroxy, alkoxy, or NR15R16, cycloalkyl, cycloakyl substituted by hydroxy, alkoxy, lower alkyl, or NR15R16, heterocycle, and heterocycle substituted by hydroxy, alkoxy, lower alkyl, or NR15R16; R1 and R14 are independently selected from the group H, lower alkyl, C2-6 alkyl substituted by hydroxy, alkoxy, or NR15R16 , cycloalkyl, cycloaklyl substituted by hydroxy, alkoxy, lower alkyl, or NRi5R16, heterocycle, and heterocycle substituted by hydroxy, alkoxy, lower alkyl, or NR R , or, alternatively, NR13R14 can form a ring having 3 to 7 atoms, said ring optionally including one or more additional hetero atoms and being optionally substituted by the group consisting of one or more lower alkyl, OR , COR17 , CO2R17, CONR 17 R 18 S02R17,andS02NRI7R18; R is selected from the group H, lower alkyl, COR17, and C02R17; and R 10, R17 and R18 are independently selected from the group H, and lower alkyl, or, alternatively, NR15R16 and NRI7R18 can each independently form a ring having 3 to 7 atoms, said ring optionally including one or more additional hetero atoms; R and R are independently selected from the group H, and lower alkyl; and *y i R" is selected from lower alkyl, and C2-6 alkyl substituted by hydroxy, alkoxy or NRI5R16. 2. The compound of formula I of claim 1, wherein R1 is selected from aryl and aryl substituted by CN and CONRl3Ru 3. The compound of formula I of claim 1 or 2, wherein R1 is selected from phenyl and phenyl substituted by CN and CONRI3R14. 4. The compound of formula I of claim 1, wherein R1 is lower alkyl. 5. The compound of formula I of any one of claims 1 to 4, wherein R is C1-10alkyl substituted by OR12 or NR10R1 l . 6. The compound of formula I of any one of claims 1 to 4, wherein R is OR 7. The compound of formula I of any one of claims 1 to 6, wherein R is H. 8. The compound of formula I of any one of claims 1 to 7, wherein R and R areH. 9. The compound of formula I of any one of claims 1 to 7, wherein R4 is C1-10 alkyl substituted by NR10R11. 10. The compound of formula I of any one of claims 1 to 9, wherein R5 is halogen. 11. The compound of formula I of any one of claims 1 to 10, wherein R9 is H. 12. The compound of formula I of claim 1 having the formula 13. A compound of formula I of claim 1 selected from the group; (±)-3-[7-[3-(2-hydroxy-ethyl)-phenylamino]-3-(4-methoxy-phenyl)-4-methyl-2-oxo-3,4-dihydro-2H-pyrimido[4,5-d]pyrimidin-l-yl]-benzonitrile ; (±)-3-[7-[3-(2-diethylamino-ethyl)-phenylamino]"3-(4-methoxy-phenyl)-4-methyl-2-oxo-3)4-dihydro-2H-pyrimido[4,5-d]pyrimidin-l-yl]-benzonitrile; and (±)-3-[7-[3-(2-dimethylamino-ethyl)-phenylamino]-3-(4-methoxy-phenyl)-4-methyl-2-oxo-334-dihydro-2H-pyrimido[4)5-d]pyrimidin-l-yl]-benzonitrile. 14. A compound of formula I of claim 1 selected from the group: (±)-3-(3-(4-methoxy-phenyl)-4-methyl-7-{3-[2-(4~methyl-piperazin-l-yl)-ethyl]» phenylamino}-2-oxo-3>4-dihydro-2H-pyrimido[4)5-d]pyrimidin-l-yl)-benzonitrile; (±)-3-[7-[3-(2-diethylamino-ethyl)-phenylamino]-3-(4-methoxy-phenyl)~4-methyl"2- oxo-3,4-dihydro-2H-pyrimido[4J5-d]pyrimidin-l-yl]-benzamide ; (±)-3-[7-[3-(2-dimethylamino-ethyl)-phenylamino]-3-(4-methoxy-phenyl)-4-fnethyl-2-oxo-3,4-dihydro-2H-pyrimido[4>5-d]pyrimidin-l-yl]-benzamide ; (±)-3-(3-(4-methoxy-phenyl)-4-methyl-7-{3-[2-(4-methyl-piperazin-l-yl)-ethyl]-phenylamino}-2-oxo-3)4-dihydro-2H-pyrimido[4>5-d]pyrimidin-l-yl)-benzamide; and (±)-3-(2-bromo-phenyl)-7-[4-(2-diethylamino-ethoxy)-phenylamino]-l,4-dimethyl-3,4-dihydro-lH-pyrimido[4)5-d]pyrimidin-2-one. 15. A compound of formula I of claim 1, which is (+)-3-(2-bromo-phenyl)-7-[4-(2-diethylamino-ethoxy)-phenylamino]-l)4-dimethyl- 3)4-dihydro-lH-pyrimido[4>5-d]pyrimidin-2-one. 16. A compound of formula I of claim 1, which is (-)-3-(2-bromo-phenyl)-7-[4-(2-diethylamino-ethoxy)-phenylamino]-l)4-dimethyl-3,4- dihydro-lH-pyrimido[4,5-d]pyrimidin-2-one. 17. A pharmaceutical composition comprising a therapeutically effective amount of a compound of any one of claims 1 to 16 and a pharmaceutical^ acceptable carrier or excipient. 18. The pharmaceutical composition of claim 17, wherein the compound is suitable for administration to a patient having cancer. 19. Compounds of any one of claims 1 to 16 for use as medicaments. 20. Use of compounds of any one of claims 1 to 16 for the preparation of medicaments for the treatment and control of cancer. 21. The use of claim 20 for the treatment and control of breast, colon, hepatic or pancreatic cancer. 22. The use of claim 20 wherein the cancer is breast or colon cancer. 23. A process for the preparation of a compound of formula I of claim 1, which process comprises wherein X is CI or S02CH3) and R!, R5, R6, R7 and R8 are as defined in claim 1, with an aniline derivative of the formula wherein R is H, and if desired, b) reacting the compound of formula lb with an acid halide or anhydride to obtain n1? R20 O R \ P O II \/ II 21 a compound of formula I, wherein R9 is C-0~C—0~C— R or COR17, and wherein R17, R19, R20 and R21 are as defined in claim 1, and/or c) if desired, converting the compound of formula I into a pharmaceutical^ acceptable salt. 24. A compound of formula I of any one of claims 1 to 16 prepared by a process according to claim 23. 25. A compound selected from the group: (±)-acetic acid 2-{3-[8-(3-cyano-phenyl)-6-(4-methoxy-phenyl)-5-methyl-7-oxo-5)6J7,8-tetrahydro-pyrimido[4)5-d]pyrimidin-2-ylamino]-phenyl}-ethyl ester and (±)-methanesulfonicacid (2-{3-[8-(3-cyano-phenyl)-6-(4-methoxy-phenyI)-5-methyl-7-oxo-5,6,7>8-tetrahydro-pyrimido[4)5-d]pyrimidin-2-ylamino]--phenyl}-ethyl)-ester. 26. The novel compounds, pharmaceutical compositions, processes, and uses as described herein before.

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