| Title of Invention | PYRAZOLE COMPOUNDS |
|---|---|
| Abstract | This invention describes novel pyrazole compound of formula (IIc): wherein R1 is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rx and Ry are taken together with their intervening atoms to form a fused, unsaturated or partially unsaturated, 5-7 membered ring having 0-3 heteroatoms; and R2 and R2' are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease. |
| Full Text |
|---|
794-kolnp-2003-granted-abstract.pdf
794-kolnp-2003-granted-assignment.pdf
794-kolnp-2003-granted-claims.pdf
794-kolnp-2003-granted-correspondence.pdf
794-kolnp-2003-granted-description (complete).pdf
794-kolnp-2003-granted-examination report.pdf
794-kolnp-2003-granted-form 1.pdf
794-kolnp-2003-granted-form 18.pdf
794-kolnp-2003-granted-form 2.pdf
794-kolnp-2003-granted-form 3.pdf
794-kolnp-2003-granted-form 5.pdf
794-kolnp-2003-granted-gpa.pdf
794-kolnp-2003-granted-reply to examination report.pdf
794-kolnp-2003-granted-specification.pdf
794-kolnp-2003-granted-translated copy of priority document.pdf
| Patent Number | 225992 | ||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Indian Patent Application Number | 794/KOLNP/2003 | ||||||||||||||||||||||||
| PG Journal Number | 49/2008 | ||||||||||||||||||||||||
| Publication Date | 05-Dec-2008 | ||||||||||||||||||||||||
| Grant Date | 03-Dec-2008 | ||||||||||||||||||||||||
| Date of Filing | 19-Jun-2003 | ||||||||||||||||||||||||
| Name of Patentee | VERTEX PHARMACEUTICALS INCORPORATED | ||||||||||||||||||||||||
| Applicant Address | 130 WAVERLY STREET, CAMBRIDGE, MA | ||||||||||||||||||||||||
Inventors:
|
|||||||||||||||||||||||||
| PCT International Classification Number | A61K 31/517, 31/519 | ||||||||||||||||||||||||
| PCT International Application Number | PCT/US01/49140 | ||||||||||||||||||||||||
| PCT International Filing date | 2001-12-19 | ||||||||||||||||||||||||
PCT Conventions:
|
|||||||||||||||||||||||||