Title of Invention	"SUBSTITUTED PHENYLACETIC ACIDS"
Abstract	Substituted phenylacetic acids, phenylethanols and related compounds are provided that are useful in treating or controlling a number of diseases associated with glucose metabolism, lipid metabolism and insulin secretion.

Full Text

Substituted Phenylacetic Acids CROSS-REFERENCES TO RELATED APPLICATIONS [0001] This application claims the benefit of Provisional application Ser. No. 60/366,961 filed March 20, 2002, the contents of which are incorporated herein by reference. STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT [0002] NOT APPLICABLE REFERENCE TO A "SEQUENCE LISTING," A TABLE, OR A COMPUTER PROGRAM LISTING APPENDIX SUBMITTED ON A COMPACT DISK. [0003] NOT APPLICABLE BACKGROUND OF THE INVENTION [0004] Diabetes mellitus, commonly called diabetes, refers to a disease process derived from multiple causative factors and characterized by elevated levels of plasma glucose, referred to as hyperglycemia. See, e.g., LeRoith, D. et al., (eds.), DIABETES MELLITUS (Lippincott-Raven Publishers, Philadelphia, PA U.S.A. 1996), and all references cited therein. According to the American Diabetes Association, diabetes mellitus is estimated to affect approximately 6% of the world population. Uncontrolled hyperglycemia is associated with increased and premature mortality due to an increased risk for microvascular and macrovascular diseases, including nephropathy, neuropathy, retinopathy, hypertension, cerebrovascular disease and coronary heart disease. Therefore, control of glucose homeostasis is a critically important approach for the treatment of diabetes. [0005] There are two major forms of diabetes: Type 1 diabetes (formerly referred to as insulin-dependent diabetes or EDDM); and Type 2 diabetes (formerly referred to as non-insulin dependent diabetes or NIDDM). [0006] Type I diabetes is the result of an absolute deficiency of insulin, the hormone which regulates glucose utilization. This insulin deficiency is usually characterized by 0-cell destruction within the Islets of Langerhans in the pancreas, which usually leads to absolute insulin deficiency. Type 1 diabetes has two forms: Immune-Mediated Diabetes Mellitus, which results from a cellular mediated autoimmune destruction of the 0 cells of the pancreas; and Idiopathic Diabetes Mellitus, which refers to forms of the disease that have no known etiologies. [0007] Type 2 diabetes is a disease characterized by insulin resistance accompanied by relative, rather than absolute, insulin deficiency. Type 2 diabetes can range from predominant insulin resistance with relative insulin deficiency to predominant insulin deficiency with some insulin resistance. Insulin resistance is the diminished ability of insulin to exert its biological action across a broad range of concentrations. In insulin resistant individuals, the body secretes abnormally high amounts of insulin to compensate for this defect. When inadequate amounts of insulin are present to compensate for insulin resistance and adequately control glucose, a state of impaired glucose tolerance develops. In a significant number of individuals, insulin secretion declines further and the plasma glucose level rises, resulting in the clinical state of diabetes. Type 2 diabetes can be due to a profound resistance to insulin stimulating regulatory effects on glucose and lipid metabolism in the main insulin-sensitive tissues: muscle, liver and adipose tissue. This resistance to insulin responsiveness results in insufficient insulin activation of glucose uptake, oxidation and storage in muscle and inadequate insulin repression of lipolysis in adipose tissue and of glucose production and secietion in liver. In Type 2 diabetes, free fatty acid levels are often elevated in obese and some non-obese patients and lipid oxidation is increased. [0008] Premature development of atherosclerosis and increased rate of cardiovascular and peripheral vascular diseases are characteristic features of patients with diabetes, with hyperlipidemia being an important precipitating factor for these diseases. [0009] Hyperlipidemia is a condition generally characterized by an abnormal increase in serum lipids in the bloodstream and, as noted above, is an important risk factor in developing atherosclerosis and heart disease. For a review of disorders of lipid metabolism, see, e.g., Wilson, J. et al., (ed.), Disorders of Lipid Metabolism, Chapter 23, Textbook of Endocrinology, 9lh Edition, (W.B. Sanders Company, Philadelphia, PA U.S.A. 1998; this reference and all references cited therein are herein incorated by reference). Serum lipoproteins are the carriers for lipids in the circulation. They are classified according to their density, chylomicrons; very low -density lipoproteins (VLDL); intermediate density lipoproteins (IDL); low density lipoproteins (LDL); and high density lipoproteins (HDL). Hyperlipidemia is usually classified as primary or secondary hyperlipidemia. Primary hyperlipidemia is generally caused by genetic defects, while secondary hyperlipidemia is generally caused by other factors, such as various disease states, drugs, and dietary factors. Alternatively, hyperlipidemia can result from both a combination of primary and secondary causes of hyperlipidemia. Elevated cholesterol levels are associated with a number of disease states, including coronary artery disease, angina pectoris, carotid artery disease, strokes, cerebral arteriosclerosis, and xanthoma. [0010] Dyslipidemia, or abnormal levels of lipoproteins in blood plasma, is a frequent occurrence among diabetics, and has been shown to be one of the main contributors to the increased incidence of coronary events and deaths among diabetic subjects (see, e.g., Joslin, E. Ann. Chim. Med. (1927) 5: 1061-1079). Epidemiological studies since then have confirmed the association and have shown a several-fold increase in coronary deaths among diabetic subjects when compared with nondiabetic subjects (see, e.g., Garcia, M. J. et al., Diabetes (1974) 23: 105-11 (1974); and Laakso, M. and Lehto, S., Diabetes Reviews (1997) 5(4): 294-315). Several lipoprotein abnormalities have been described among diabetic subjects (Howard B., et al., Artherosclcrosis (1978) 30: 153-162). [0011 j What is needed in the art are new compounds and methods useful for the treatment of insulin resistance, Type 2 diabetes, hyperlipidemia and hyperuricemia. The present invention fulfills this and other needs by providing such compounds, compositions and methods for alleviating insulin resistance, Type 2 diabetes, hyperlipidemia and hyperuricemia. BRIEF SUMMARY OF THE INVENTION [0012} In one aspect, the present invention provides compounds having the formula: (Figure Remove) in which the letter X is selected ifrom 0, S, SO, SOa and NR, wherein R is H, (Ci-Cg)alkyl, COR", COORa and CONRaRb wherein R° and Rb are each independently selected from H and (Ci-Cg)alkyl; the letter Y represents CH2ORC, CO2RC, CHO, CONRcRm, CH(=NRC), CH(-NORC) or a carboxylic acid surrogate, wherein Rc is selected from H, (Ci-Cg)alkyl, (Cj-C8)alkenyl, (C3-C8)alkynyl, (C3-C7)cycloalkyl, (C4-C8)cycloalkyl-alkyl, aryl, aryl(C,-C8)alkyl and (Ci-Cg)alkylene-Z, wherein Z is selected from CORd, COORd, NRdRe, NRdCONRcRf, NRdCORe, NRdCOORe and CONRdRe wherein Rd, Re and Rf are each independently selected from H, (Ci-Cg)alkyl and phenyl, or optionally two of Rd, Rc and Rf when attached to the same nitrogen atom are combined to form a five- or six-membered ring; and wherein Rm is selected from H, (Ci-Cg^lkyl, aryl, OH and S02Rn, wherein Rn is selected from (Ci-Cg)alkyl, (C,-Cg)haloalkyl, (CrC8)aralkyl, (C2-C8)heteroalkyl, aryl, heteroaryl, (Ci-Cg)alkoxy, aryloxy, alkylamino, dialkylamino, arylamino, diarylamino, haloalkylamino and di(haloalkyl)amino, and Rm and Rc are optionally combined with the nitrogen atom to which each is attached to form a five- or six-membered ring. [0013] HAr represents a heteroaryl moirly, optionally substituted with from one to three substituents independently selected from halogen, hydroxy, (Ci-Cs)alkyl, aryl(Ci-C8)alkyl, (C,-C8)alkoxy, (C2-C8)alkenyl, (C2-C8)alkynyl, (C3-C7)cycIoalkyl, (C4-C8)cycloalkyl-alkyl, (C|-C8)heteroalkyl, (CrC5)heterocyclyl, aryl, aryloxy, heterosubstituted(C3-C7)cycloalkyl, heteroalkyl substituted (C3-C7)cycloalkyl, (Ci-C8)haloalkyl, O(C|-Cg)haloalkyl, nitro, cyano, C02R6, COR8, NR8Rh, S(0)(1R!\ S02NRgRh, NR^ONR11^, NRgCORh, NRBCOORh and CONR8Rh, wherein Rg, Rh and R1 are each independently selected from H and (Ci-Cg)alkyl, or optionally two of R8, Rh and R1 when attached to the same nitrogen atom are combined to form a five- or six-membered ring, and the subscript q is an integer of from 0 to 2. [0014] A variety of het.eroaryl groups provide compounds having the desired activity. In particular, the heteroai yl groups can be monocyclic or fused bicyclic heteroaryl groups. More particularly, one group of suitable monocyclic heteroaryl groups are provided in Figure 1 A. In this Figure, the line extending from the ring indicates the point of attachment to the remainder of the compound and can be made through any available valence on the ring. Other examples of'neteroaryl giuups are provided in Figure IB, which illustrates preferred fused-bicyclic heteroaryl groups, wherein attachment to the remainder of the compound can take place through an available valence on either ring. (0015J Returning to formulae la and Ib, the subscripts m and p indicate the presence of substituents on their repective rings, wherein each substituent present can be the same or different from any other substituent. More particularly, the subscript m is an integer of from 0 to 4, and the subscript p is an integer of from 0 to 3. More preferably the subscript m is an integer of from 0 to 3, and the subscript p is an integer of from 0 to 3. Still more preferably, the subscript m is an integer of from 0 to 2, and the subscript p is an integer of from 0 to 2. Most preferably, the subscript m is 0, I or 2 and the subscript p is 1 or 2. [0016] Each R1 and R3 represents a substituent independently selected from halogen, hydroxy, (Ci-Cg)alkyl, (C2-Cg)alkenyl, (C2-C8)alkynyl, (C|-C8)alkoxy, (C3-C7)cycloalkyl, (C4-Cg)cycloalkyl-alkyl, (Ci-Cg)haloalkyl, (Ci-Cg)heteroalkyl, (C2-C5)heterocyclyl, heterosubstituted(C3-07)cycloalkyl, heteroalkyl substituted (C3-C7)cycloalkyl, 0(d-Cg)haloalkyl, nitro, cyano, phenyl, 0-phenyl, NRj-phenyl, S(0)r-phenyl, CORJ, COORJ, m>R\ S(0)rRj, SO2NRJRk, NRjCONRkR', NRjCORk, NRjCOORk and CONRjRk wherein the phenyl ring is optionally substituted and Rj, Rk and R1 are each independently selected from H, (Ci-Cg)alkyl and (Ci-C8)haloalkyl, or optionally two of Rj, Rk and R1 when attached to the same nitrogen atom are combined to form a five- or six-membered ring, and the subscript r is an integer of from 0 to 2. The subscript m is an integer of from 0 to 4 and the subscript p is an integer of from 0 to 3, [0017] The symbol R2 represents a member selected from H, (Ci-Cg)alkyl, (Ci-Cg)haloalkyl, (Ci-Cg)aralkyl and (d-C4)alkylene-Z, wherein Z is as defined above. (0018J In addition to compounds having formula la or Ib above, the present invention further includes all salts thercc >f, and particularly, pharmaceutically acceptable salts thereof. Still further, the invention includes compounds that are single isomers of the above formula (e.g., single enantiomers of'.-ompounds having a single chlral center), as well as prodrug forms thereof. [0019] In other aspects., the present invention provides compositions containing one or more compounds of Formula la or Ib, as well as methods for the use of such compounds and compositions, eithci alone or in combination with other pharmaceutical agents as provided in detail below. In i'/articular, the present invention provides methods of using the compounds and/or compositions for the treatment of type II diabetes, hyperlipidemia, hyperuricemia, and for the modulation of insulin resistance. Additionally, the present invention provides methods of usivig the compounds and/or compositions for the treatment of diseases modulated by any of the isoforms of peroxisome proliferation activated receptor (PPAR). [0020] Still further, the present invention provides compositions and methods as noted, wherein the compound used is, a single isomer of a compound of Formula la or Fb, or a prodrug form thereof. BRIEF DESCRIPTION OF THE DRAWINGS [00211 Figure 1 illustrates a variety of heteroaryl groups (HAr) useful in compounds of formula I. Figure 1A provides selected monocyclic heteroaryl groups while Figure IB provides selected fused hicyclic heteroaryl groups. Each of the groups is optionally substituted with R4 substituents that can be the same or different. [0022] Figure 2 illustrates a family of preferred sub-generic formulae for compounds of the invention wherein HAr is benzoxazol-2-yl; benzothiazol-2-yl and benzimidazol-2-yl. [0023] Figure 3 illustrates another family of preferred sub-generic formulae for compounds of the invention, wherein HAr is a fused bicyclic heteroaryl group. (0024) Figure 4 illustrates yet another family of preferred sub-generic formulae for compounds of the invention wherein HAr is benzoxazol-2-yl, benzothiazol-2-yl and benzotriazol-2-yl (see Figure 4A). Figure 4B illustrates other preferred compounds having carboxylic acid surrogates in place of COzR0. [0025J Figures 5 illustrates yet another family of preferred sub-generic formulae for compounds of the invention wherein HAr is a monocyclic heteroaryl group selected from oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyrazolyl and triazolyl (see Figures 5A and 5B). Figure 5C illustrates other preferred compounds having carboxylic acid surrogates in place of CO2RC. [0026] Figure 6 is a histogram illustrating the glucose lowering effect of selected compounds of the invention in oh/ob mice. DETAILED DESCRIPTION OF THE INVENTION Abbreviations and Definitions [0027] 'he abbreviations used herein are conventional, unless otherwise defined. [0028] "i Inless otherwise stated, the following terms used in the specification and claims have .|i meanings given below: 00 2'>| "Alkyl" refers to a linear saturated monovalent hydrocarbon radical or a branched a' mated monovalent hydrocarbon radical having the number of carbon atoms indicated in ihe prefix. For example, (Ci-C6)alkyl is meant to include methyl, ethyl, «-propyl, 2-propyl, /erf-butyl, pentyl, and the like. For each of the definitions herein (e.g., alkyl, alkenyl, alkoxy, aralkyloxy), when a prefix is not included to indicate the number of main chain carbon atoms in an alkyl portion, the radical or portion thereof will have six or fewer main chain carbon atoms. [0030] "Alkylene" refers to a linear saturated divalent hydrocarbon radical or a branched saturated divalent hydrocarbon radical having the number of carbon atoms indicated in the prefix. For example, (Ci-C6)alkylene is meant to include methylene, ethylene, propylene, 2-methylpropylene, pentylene, and the like. [0031] "Alkenyl" refers to a linear monovalent hydrocarbon radical or a branched monovalent hydrocarbon radical having the number of carbon atoms indicated in the prefix and containing at least one double bond, but no more than three double bonds. For example, (C2-C6)alkenyl is meant to include, ethenyl, propenyl, 1,3-butadienyl and the like. [0032] "Alkynyl" means a linear monovalent hydrocarbon radical or a branched monovalent hydrocarbon radical containing at least one triple bond and having the number of carbon atoms indicated in the prefix. The term "alkynyl" is also meant to include those alkyl groups having one triple bond and one double bond. For example, (C2-C6)alkynyl is meant to include ethynyl, propynyl, and the like. [0033J "Alkoxy", "aryloxy" or "aralkyloxy" refers to a radical -OR wherein R is an alkyl, aryl or arylalkyl, respectively, as defined herein, e.g., methoxy, phenoxy, benzyloxy, and the like. [0034] "Aryl" refers to ;i monovalent monocyclic or bicyclic aromatic hydrocarbon radical of 6 to 10 ring atoms which is substituted independently with one to four substituents, preferably one, two, or three substituents selected from alkyl, cycloalkyl, cycloalkyl-alkyl, halo, nitro, cyano, hydroxy, alkoxy, amino, acylamino, mono-alkylamino, di-alkylamino, haloalkyl, haloalkoxy, heteroalkyl, COR (where R is hydrogen, alkyl, cycloalkyl, cycloalkyl-alkyl, phenyl or phenylalkyl), -(CR'R")n-COOR (where n is an integer from 0 to 5, R' and R" are independently hydrogen or alkyl, and R is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, phenyl or phenylalkyl) or ~~(CR'R")n-CONR*Ry (where n is an integer from 0 to 5, R' and R" X y are independently hydn igen or alk yl, and R and R are independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, phenyl or phenylalkyl). More specifically the term aryl includes, but is not limited to, phenyl, biphenyl, 1-naphthyl, and 2-naphthyl, and the substituted forms thereof. [0035] "Aralkyl" or" Ai y!((:rCx)alkyl" refers to the radical -R*Ry where RX is an alkylene y group (having eight or fewer main chain carbon atoms) and R is an aryl group as defined above. Thus, "aralkyl" refers to groups such as, for example, benzyl, phenylethyl, 3-(4- X y nitrophenyl)~2-methylbu'tyl, and the like. Similarly, "Aralkenyl" means a radical -R R X V where R is an alkenylene group (an alkylene group having one or two double bonds) and R is an aryl group as defined above, e.g., styryl, 3-phenyl-2-propenyl, and the like. [0036] "Cycloalkyl" refers to a monovalent cyclic hydrocarbon radical of three to seven ring carbons. The cycloalkyl group may have one double bond and may also be optionally substituted independently with one, two, or three substituents selected from alkyl, optionally substituted phenyl, or -C(0)RZ (where Rz is hydrogen, alkyl, haloalkyl, amino, mono-alkylamino, di-alkylarnino, hydroxy, alkoxy, or optionally substituted phenyl). More specifically, the term cycloalkyl includes, for example, cyclopropyl, cyclohexyl, cyclohexenyl, phenylcyclohexyl, 4-carboxycyclohexyl, 2-carboxamidocyclohexenyl, 2-dimethylaminocarbonyl-cyclohexyl, and the like. J0037] "Cycloalkyl-alkyl" means a radical -RXR wherein R is an alkylene group and Ry is a cycloalkyl group as defined herein, e.g., cyclopropylmethyl, cyclohexenylpropyl, 3-cyclohexyl-2-methylpropyl, and the like. The prefix indicating the number of carbon atoms (e.g., C-j-Cio) refers to the total number of carbon atoms from both the cycloalkyl portion and the alkyl portion. [0038] "Haloalkyl" refers to an alkyl group which is substituted with one or more same or different halo atoms, e.g., -C H2C1, -CF3, -CH2CF3, -CH2CC13, and the like, and further includes those alkyl groups such as perfluoroalkyl in which all hydrogen atoms are replaced by fluorine atoms. The prefix "halo" and the term "halogen" when used to describe a substituent, refer to -F, -Cl,. -Br and -I. [0039] "Heteroalkyl" means an alkyl radical as defined herein with one, two or three substituents independent ly selected from cyano, -ORW, -NR"Ry, and -S(O)nRz (where n is an integer from 0 to 2 ), wilh the understanding that the point of attachment of the heteroalkyl W radical is through a carbon atom of the heteroalkyl radical. R is hydrogen, alkyl, cycloalkyl, cycloalkyl-alkyi, aryl, aralkyl, alkoxycarbonyl, aryloxycarbonyl, carboxamido, or mono- or di-alkylcarbamoyl. Rx is hydrogen, alkyl, cycloalkyl, cycloalkyl-alkyl, aryl or aralkyl. Ry is hydrogen, alkyl, cycloalkyl, cycloalkyl-alkyl, aryl, aralkyl, alkoxycarbonyl, aryloxycarbonyl, carboxamido, mono- or di-alk\ K,arbamoyl or alkylsulfonyl. Rz is hydrogen (provided that n is 0), alkyl, cycloalkyl, cycloalkyl-alkyl, aryl, aralkyl, amino, mono-alkylamino, di-alkylamino, or hydroxyalky'i Representative examples include, for example, 2-hydroxyethyl, 2,3-dihydroxypropyl, 2 methoxyethyl, benzyloxymethyl, 2-cyanoethyl, and 2-methylsulfonyl-ethyl. Far each of the above, Rw, Rx ,Ry, and Rz can be further substituted by amino, fluorine, alkyiarnino, di-alkylamino, OH or alkoxy. Additionally, the prefix indicating the number of carbon atoms (e.g., Ci-Cio) refers to the total number of carbon atoms in the portion of the heteroalkyl group exclusive of the cyano, -ORW, -NR"Ry, or -S(O)nRz portions. [0040] "Heteroaryl" means a monovalent monocyclic or bicyclic radical of 5 to 12 ring atoms having at leapt one aromatic ring containing one, two, or three ring heteroatoms selected from N, 0, or S, the remaining ring atoms being C, with the understanding that the attachment point of the heteroaryl radical will be on an aromatic ring. The heteroaryl ring is optionally substituted independently with one to four substituents, preferably one or two substituents, selected from alkyl, cycloalkyl, cycloalkyl-alkyl, halo, nitro, cyano, hydroxy, alkoxy, amino, acylamino, mono-alkylamino, di-alkylamino, haloalkyl, haloalkoxy, heteroalkyl, -COR (where R is hydrogen, alkyl, phenyl or phenylalkyl, -(CR'R") -COOR (where n is an integer from 0 to 5, R' and R" are independently hydrogen or alkyl, and R is hydrogen, alkyl, cycloalkyl, cycloalkyl-alkyl, phenyl or phenylalkyl), or-(CR'R") - CONR R (where n is an integer from 0 to 5, R' and R" are independently hydrogen or alkyl, and R and R are, independently of each other, hydrogen, alkyl, cycloalkyl, cycloalkyl-alkyl, phenyl or phenylalkyl). More specifically the term heteroaryl includes, but is not limited to, pyridyl, furanyl, thienyl, thiazolyl, isothiazolyl, triazolyl, imidazolyl, isoxazolyl, pyrrolyl, pyrazolyl, pyridazinyl, pyrimidinyl, benzofuranyl, tetrahydrobenzofuranyl, isobenzofuranyl, benzothiazolyl, benzoisothiazolyl, benzotriazolyl, indolyl, isoindolyl, benzoxazolyl, quinolyl, tetrahydroquinolinyl, isoquinolyl, benzimidazolyl, benzisoxazolyl or benzothienyl, and the derivatives thereof. [0041] "Heterocycly!" or "cycloheteroalkyl" means a saturated or unsaturated non-aromatic cyclic radical of 3 to 8 ring atoms in which one or two ring atoms are heteroatoms selected from 0, NR (v/here R is independently hydrogen or alkyl) or S(O)n (where n is an integer from 0 to 2). the remaining ring atoms being C, where one or two C atoms may optionally be replaced by a carbouyl group. The heterocyclyl ring may be optionally substituted independently with one, two, or three substituents selected from alkyl, cycloalkyl, cycloalkyl-alkyl, halo, nitro, cyano, hydroxy, alkoxy, amino, mono-alkylamino, di-alkylamino, haloalkyl, haloalkoxy, -COR (where R is hydrogen, alkyl, cycloalkyl, cycloalkyl-alkyl, phenyl or phenylalkyl), -(CR'R")n-COOR (n is an integer from 0 to 5, R' and R" are independently hydrogen or alkyl, and R is hydrogen, alkyl, cycloalkyl, cycloalkyl-alkyl, phenyl ov phenylalkyl), or ~(CR'R")n-CONR*Ry (where n is an integer from 0 to 5, R' and R" are independently hydrogen or alkyl, R and R are, independently of each other, hydrogen, alky), cycloalkyl, cycloalkylalkyl, phenyl or phenylalkyl). More specifically the term heterocyclyl includes, but is not limited to, tetrahydropyranyl, piperidino, N-methylpiperidin-3~yl, piperazino, N-methylpyrrolidin-3-yl, 3-pyrrolidino, 2-pyrrolidon-l-yl, morpholino, thiomorpholino, thiomorpholino-1 -oxide, thiomorpholino-1,1 -dioxide, pyrrolidinyl, and the derivatives thereof. The prefix indicating the number of carbon atoms (e.g., C3-Cio) refers to the total number of carbon atoms in the portion of the cycloheteroalkyl or heterocyclyl group exclusive of the number of heteroatoms. [0042] "Heterocyclylalkyl" or "Cycloheteroalkyl-alkyl" means a radical -RxRy where R* is an alkylene group and R is a heterocyclyl group as defined herein, e.g., tetrahydropyran-2-ylmethyl, 4-methylpiperazin-l-ylethyl, 3-piperidinylmethyl, and the like. [0043J "Heterosubstituted cycloalkyl" means a cycloalkyl group wherein one, two, or three hydrogen atoms are replaced by substituents independently selected from the group consisting of cyano, hydroxy, alkoxy, amino, acylamino, mono-alkylamino, di-alkylamino, or -SOnR (where n is an integer from 0 to 2 and when n is 0, R is hydrogen or alkyl and when n is 1 or 2, R is alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, amino, acylamino, mono-alkylamino, di-alkylamino, or hydroxyalkyl). Examples include 4-hydroxycyclohexyl, 2-aminocyclohexyl etc. [0044] "Heteroalkyl substituted cycloalkyl" means a cycloalkyl group wherein one, two, or three hydrogen atoms are replaced independently by heteroalkyl groups, with the understanding that the heteroalkyl group is attached to the cycloalkyl group via a carbon-carbon bond. Examples include 1-hydroxymethyl-cyclopent-l-yl, 2-hydroxymethyl-cyclohex-2-yl and the like. [0045] "Heteroalkyl substituted 'heterocyclyl" means a heterocyclyl group wherein one, two, or three hydrogen atoms are replaced independently by heteroalkyl groups, with the understanding that the heteroalkyl group is attached to the heterocyclyl group via a carbon-carbon bond. Examples include 4-hydroxymethyl-piperidin-l-yl, and the like. [0046] "Optionally substituted phenyl" means a phenyl ring which is optionally substituted independently with one to four substituents, preferably one or two substituents selected from alkyl, cycioalkyl, cycloalkyl-alkyl, halo, nitro, cyano, hydroxy, alkoxy, amino, acylamino, mono-alkylamino, di-alkylamino, haloalkyl, haloalkoxy, heteroalkyl, -COR (where R is hydrogen, alkyl, phenyl or phenylalkyl, -(CR'R")n-COOR (where n is an integer from 0 to 5, R' and R" are independently hydrogen or alkyl, and R is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, phenyl or phenylalkyl), or -(CR'R")n-CONR R (where n is an integer from 0 to 5, R' and R" are independently hydrogen or alkyl, and R and R are, independently of each other, hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, phenyl or phenylalkyl). [0047] For each of the definitions above, the term "di-alkylamino" refers to an amino moiety bearing two alkyl groups that can be the same, or different. [0048] As used herein, the term "carboxylic acid surrogate" refers to those moieties that are used as surrogates for a carboxylic acid moiety. Such groups are generally known to one of skill in the art (see, for example, THE PRACTICE OF MEDICINAL CHEMISTRY; Wermuth, C.G., ed., Academic Press, New York, 1996, page 203). Suitable isosteres or surrogates include -C(O)NHSO2R wherein R can be alkyl, haloalkyl, heteroalkyl, aralkyl, aryl, heteroaryl, heterocyclyl, alkoxy, haloalkoxy, aryloxy, alkylamino, haloalkylamino, dialkylamino, dihaloalkylamino, arylamino, diarylamino, arakylamino, diarakylamino or other groups to provide an overall acidic character to the moiety; sulfonic acids; sulfinic acids; phosphonic acids; phosphinic acids; activated sulfonamides (e.g., -SC^NHX wherein X is an electron withdrawing group relative to an alkyl group, such as an acyl group or aryl group; activated carboxamides (e.g., -C(O)NHCN); hydroxamic acids (-C(O)NHOH); acidic heterocycles or substituted heterocycles (e.g., tetrazoles, triazoles, hydroxypyrazoles, hydroxyoxazoles, hydroxythiadiazoles); and acidic alcohols (e.g., -C(CF3)2OH or -CH(CF3)OH). [0049J Compounds (hat have the same molecular formula but differ in the nature or sequence of bonding of their atoms or the arrangement of their atoms in space are termed "isomers". Isomers that differ in the arrangement of their atoms in space are termed "stereoisomers". Stercoisomers that are not mirror images of one another are termed "diastereomers" and those that are non-superimposable mirror images of each other are termed "enantiomers". When a compound has an asymmetric center, for example, it is bonded to four different groups, a pair of enantiomers is possible. An enantiomer can be characterized by the absolute configuration of its asymmetric center and is described by the R- and S-sequencing rules of Calm and Prelog, or by the manner in which the molecule rotates the plane of polarized light and designated as dextrorotatory or levorotatory (i.e., as (+) or (-)-isomers respectively). A chiral compound can exist as either individual enantiomer or as a mixture thereof. A mixHue containing equal proportions of the enantiomers is called a "racemic mixture". |OOSO| The compounds ot this invention may exist in stereoisomeric form if they possess one or more asymmetric centers or a double bond with asymmetric substitution and, therefore, can be produced as individual stereoisomers or as mixtures. Unless otherwise indicated, the description is intended to include individual stereoisomers as well as mixtures. The methods for the determination of stereochemistry and the separation of stereoisomers are well-known in the art (see discussion in Chapter 4 of ADVANCED ORGANIC CHEMISTRY, 4th edition J. March, John Wiley and Sons, New York, 1992). [0051] "Pharmaceutically acceptable salt" of a compound means a salt that is pharmaceutically acceptable and that possesses the desired pharmacological activity of the parent compound. Such salts include: [0052] (1) acid addition salts, formed with inorganic acids such as hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid, and the like; or formed with organic acids such as acetic acid, propionic acid, hexanoic acid, cyclopentanepropionic acid, glycolic acid, pyruvic acid, lactic acid, malonic acid, succinic acid, malic acid, maleic acid, fumaric acid, tartaric acid, citric acid, benzoic acid, 3-(4-hydroxybenzoyl)benzoic acid, cinnamic acid, mandelic acid, methanesulfonic acid, ethanesulfonic acid, 1,2-ethane-disulfonic acid, 2-hydroxyethanesultonic acid, benzenesulfonic acid, 4-chlorobenzenesulfonic acid, 2-napthalenesulfonic acid, 4-toluenesulfonic acid, camphorsulfonic acid, 4-methylbicyclo[2.2.2]-oct-2-ene-l-carboxylic acid, glucoheptonic acid, 3-phenylpropionic acid, trimethylacetic acid, tertiary butylacetic acid, lauryl sulfuric acid, gluconic acid, glutamic acid, hydroxynapthoic acid, salicylic acid, stearic acid, muconic acid, and the like; or [0053] (2) salts formed when an acidic proton present in the parent compound either is replaced by a metal ion, e.g., an alkali metal ion, an alkaline earth ion, or an aluminum ion; or coordinates with an organic base such as ethanolamine, diethanolamine, triethanolamine, trimethylamine, jV-methylglui aiviine, and the like. [0054] "Prodrugs" means any compound which releases an active parent drug according to Formula la or Ib in vivo w'nen such prodrug is administered to a mammalian subject. Prodrugs of a compoun j of Formula la or Ib are prepared by modifying functional groups present in the compoun d of Formula la or Ib in such a way that the modifications may be cleaved I'M vivo to rcle ase the parent compound. Prodrugs include compounds of Formula la or Ib wherein a b ,'ioxy, amino, or sulfhydryl group in a compound of Formula la or Ib is bonded to any gi [0055] "Protecting group" refers to a grouping of atoms that when attached to a reactive group in a molecule masks, reduces or prevents that reactivity. Examples of protecting groups can be found in T.W. Greene and P.O. Wuts, PROTECTIVE GROUPS IN ORGANIC CHEMISTRY, (Wiley, 2nd ed. 1991) and Harrison and Harrison et al., COMPENDIUM OF SYNTHETIC ORGANIC METHODS, Vols. 1-8 (John Wiley and Sons. 1971-1996). Representative amino protecting groups include formyl, acetyl, trifluoroacetyl, benzyl, benzyloxycarbonyl (CBZ), rerf-butoxycarbonyl (Boc), trimethyl silyl (IMS), 2- trimethylsilyl-ethanesulfonyl (SES), trityl and substituted trityl groups, allyloxycarbonyl, 9- nuorenylmethyloxycarbonyl (FMOC), nitro-veratryloxycarbonyl (NVOC) and the like. Representative hydroxy protecting groups include those where the hydroxy group is either acylated or alkylated such as benzyl and trityl ethers as well as alkyl ethers, tetrahydropyranyl ethers, trialkylsilyl ethers and allyl ethers. [0056] Turning next to the compositions of the invention, the term "pharmaceutically acceptable carrier or excipient" means a carrier or excipient that is useful in preparing a pharmaceutical composition that is generally safe, non-toxic and neither biologically nor otherwise undesirable, and includes a carrier or excipient that is acceptable for veterinary use as well as human pharmaceutical use. A "pharmaceutically acceptable carrier or excipient" as used in the specification and claims includes both one and more than one such carrier or excipient. [0057] With reference to the methods of the present invention, the following terms are used with the noted meanings: [0058) The terms "treating" or "treatment" of a disease includes: 10059J (1) preventing the disease, i.e., causing the clinical symptoms of the disease not to develop in a mammal that may be exposed to or predisposed to the disease but does not yet experience or display symptoms of the disease, [0060] (2) inhibiting the disease, i.e., arresting or reducing the development of the disease or its clinical symptoms, or |0061 ] (3) relieving the disease, i.e., causing regression of the disease or its clinical symptoms. [0062) The term "thcrapeutically effective amount" means the amount of the subject compound that will elicit the biological or medical response of a tissue, system, animal or human that is being sought by the researcher, veterinarian, medical doctor or other clinician. "A therapeutically effective amount" includes the amount of a compound that, when administered to a mammal for treating a disease, is sufficient to effect such treatment for the disease. The "therapeutically effective amount" will vary depending on the compound, the disease and its severity and the age, weight, etc., of the mammal to be treated. [0063[ The term "mammal" includes, without limitation, humans, domestic animals (e.g., dogs or cats), farm animals (cows, horses, or pigs), monkeys, rabbits, mice, and laboratory animals. [0064) The term "insulin resistance" can be defined generally as a disorder of glucose metabolism. More specifically, insulin resistance can be defined as the diminished ability of insulin to exert its biological action across a broad range of concentrations producing less than the expected biologic effect, (see, e.g., Reaven, G. M., /. Basic & Clin. Phys. & Pharm. (1998) 9: 387-406 and Flier, J. Ann Rev. Med. (1983) 34: 145-60). Insulin resistant persons have a diminished ability to properly metabolize glucose and respond poorly, if at all, to insulin therapy. Manifestations of insulin resistance include insufficient insulin activation of glucose uptake, oxidation and storage in muscle and inadequate insulin repression of lipolysis in adipose tissue and of glucose production and secretion in liver. Insulin resistance can cause or contribute to polycystic ovarian syndrome, Impaired Glucose Tolerance (IGT), gestational diabetes, hypertension, obesity, atherosclerosis and a variety of other disorders. Eventually, the insulin resistant individuals can progress to a point where a diabetic state is reached. The association of insulin resistance with glucose intolerance, an increase in plasma triglyceride and a decrease in high-density lipoprotein cholesterol concentrations, high blood pressure, hyperuricemia, smaller denser low-density lipoprotein particles, and higher circulating levels of plaminogcn activator inhibitor-1), has been referred to as "Syndrome X" (see, e.g., Reaven, G. M., P/IP iol. Rev. (1995) 75: 473-486). [0065] The term "diabetes mellitus" or "diabetes" means a disease or condition that is generally characterized by metabolic defects in production and utilization of glucose which result in the failure to ni;unlain appropriate blood sugar levels in the body. The result of these defects is elevated bloo d r.lucose, referred to as "hyperglycemia." Two major forms of diabetes are Type 1 di abct'-s and Type 2 diabetes. As described above, Type 1 diabetes is generally the result of an absolute deficiency of insulin, the hormone which regulates glucose utilization. Type 2 diabetes often occurs in the face of normal, or even elevated levels of insulin and can result from the inability of tissues to respond appropriately to insulin. Most Type 2 diabetic patients are insulin resistant and have a relative deficiency of insulin, in that insulin secretion can not compensate for the resistance of peripheral tissues to respond to insulin. In addition, many Type 2 diabetics are obese. Other types of disorders of glucose homeostasis include Impaired Glucose Tolerance, which is a metabolic stage intermediate between normal glucose homeostasis and diabetes, and Gestational Diabetes Mellitus, which is glucose intolerance in pregnancy in women with no previous history of Type 1 or Type 2 diabetes, [0066] The term "secondary diabetes" is diabetes resulting from other identifiable etiologies which include: genetic defects of 0 cell function (e.g.. maturity onset-type diabetes of youth, referred to as "MODY," which is an early-onset form of Type 2 diabetes with autosomal inheritance; see, e.g., Fajans S. et al, Diabet. Med. (1996) (9 Suppl 6): S90-5 and Bell, G. et al.,Annu. Rev. PhysioL (1996) 58: 171-86; genetic defects in insulin action; diseases of the exocrine pancreas (e.g., hemochromatosis, pancreatitis, and cystic fibrosis); certain endocrine diseases in which excess hormones interfere with insulin action (e.g., growth hormone in acromegaly and cortisol in Gushing's syndrome); certain drugs that suppress insulin secretion (e.g., phenytoin) or inhibit insulin action (e.g., estrogens and glucocorticoids); and diabetes caused by infection (e.g., rubella, Coxsackie, and CMV); as well as other genetic syndromes. [0067] The guidelines for diagnosis for Type 2 diabetes, impaired glucose tolerance, and gestational diabetes have been outlined by the American Diabetes Association (see, e.g., The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus, Diabetes Care, (1999)Vol2(Suppll):S5-19). [0068] The term "hyperinsulinernia" refers to the presence of an abnormally elevated level of insulin in the blood. Similarly, the term "hyperuricemia" refers to the presence of an abnormally elevated level of uric acid in the blood. The term "hyperlipidemia" refers to the presence of an abnormally elevated level oflipids in the blood. Hyperlipidemia can appear in at least three forms: (1) hypercholesknolemia, i.e., an elevated cholesterol level; (2) hypertriglyceridemia, i.e., an elevated triglyceride level; and (3) combined hyperlipidemia, i.e., a combination of hypercholestr;rolemia and hypertriglyceridemia, [0069] The term "secretagoguc" means a substance or compound that stimulates secretion. For example, an insulin secretagogue is a substance or compound that stimulates secretion of insulin. [0070] The term "hemoglobin" or "Hb" refers to a respiratory pigment present in erythrocytes, which is largely responsible for oxygen transport. A hemoglobin molecule comprises four polypeplide subuni ts (two a chain systems and two /3 chain systems, respectively). Each subunit is fon ned by association of one globin protein and one heme molecule which is an iron-protop* jrphyrin complex. The major class of hemoglobin found in normal adult hemolysale is adult hemoglobin (referred to as "HbA"; also referred to HbAo for distinguishing it from glycated hemoglobin, which is referred to as "HbAi," described infra) having a.$i subunits. Trace components such as HbAz (0362) can also be found in normal adult hemolysate. [0071] Among classes of adult hemoglobin HbAs, there is a glycated hemoglobin (referred to as "HbAi," or "glycosylated hemoglobin"), which may be further fractionated into HbAiai, HbAiaz, HbAib, and HbA|C with an ion exchange resin fractionation. All of these subclasses have the same primary structure, whiich is stabilized by formation of an aldimine (Schiff base) by the amino group of N-terminal valine in the /3 subunit chain of normal hemoglobin HbA and glucose (or, glucose-6-phosphate or fructose) followed by formation of ketoamine by Amadori rearrangement. [0072] The term "glycosylated hemoglobin" (also referred to as "HbA|c>", "GHb", "hemoglobin - glycosylated", "diabetic control index" and "glycohemoglobin"; hereinafter referred to as "hemoglobin A|C") refers to a stable product of the nonenzymatic glycosylation of the (3-chain of hemoglobin by plasma glucose. Hemoglobin AIC comprises the main portion of glycated hemoglobins in the blood. The ratio of glycosylated hemoglobin is proportional to blood glucose level. Therefore, hemoglobin A)C rate of formation directly increases with increasing plasma glucose levels. Since glycosylation occurs at a constant rate during the 120-day lifespan of an erythrocyte, measurement of glycosylated hemoglobin levels reflect the average blood glucose level for an individual during the preceding two to three months. Therefore determination of the amount of glycosylated hemoglobin HbAic can be a good index for carbohydrate metabolism control. Accordingly, blood glucose levels of the last two months can be estimated on the basis of the ratio of HbA|C to total hemoglobin Hb. The analysis of the hemoglobin A], in blood is used as a measurement enabling long-term control of blood glucose level (see, e.g., Jain, S., etal., Diabetes (1989) 38: 1539-1543; Peters A., et ai.JAMA (1996) 276: 1246-1252). (0073] The term "symptom" of diabetes, includes, but is not limited to, polyuria, polydipsia, and polyphagia, as used herein, incorporating their common usage. For example, "polyuria" means the passage of a large volume of urine during a given period; "polydipsia" means chronic, excessive thirst; a.nd "polyphagia" means excessive eating. Other symptoms of diabetes include, e.g., increased susceptibility to certain infections (especially fungal and staphylococcal infections), nausea, and ketoacidosis (enhanced production of ketone bodies in the blood). [0074] The term "complication" of diabetes includes, but is not limited to, microvascular complications and macrovascular complications. Microvascular complications are those complications which generally result in small blood vessel damage. These complications include, e.g., retinopathy (the impairment or loss of vision due to blood vessel damage in the eyes); neuropathy (nerve damage and foot problems due to blood vessel damage to the nervous system); and nephropathy (kidney disease due to blood vessel damage in the kidneys). Macrovascular complications are those complications which generally result from large blood vessel damage. These complications include, e.g., cardiovascular disease and peripheral vascular disease. Cardiovascular disease refers to diseases of blood vessels of the heart. See. e.g., Kaplan, R. M., et al., "Cardiovascular diseases" in HEALTH AND HUMAN BEHAVIOR, pp. 206-242 (McGraw-Hill, New York 1993). Cardiovascular disease is generally one of several forms, including, e.g., hypertension (also referred to as high blood pressure), coronary heart disease, stroke, and rheumatic heart disease. Peripheral vascular disease refers to diseases of any of the blood vessels outside of the heart. It is often a narrowing of the blood vessels that carry blood to leg and arm muscles. [00751 The term "atherosclerosis" encompasses vascular diseases and conditions that are recognized and understood by physicians practicing in the relevant fields of medicine. Atherosclerotic cardiovascular disease, coronary heart disease (also known as coronary artery disease or ischemic heart disease), cerebrovascular disease and peripheral vessel disease are all clinical manifestations of atherosclerosis and are therefore encompassed by the terms "atherosclerosis" and "atherosclerotic disease". [0076] The term "antihyperlipidemic" refers to the lowering of excessive lipid concentrations in blood to desired levels. Similarly, the term "antiuricemic" refers to the lowering of excessive uric acid concentrations in blood to desired levels. |0077) The term "modulate" refers to the treating, prevention, suppression, enhancement or induction of a function or condition. For example, the compounds of the present invention can modulate hyperlipidemia by lowering cholesterol in a human, thereby suppressing hyperlipidemia. [0078] The term "triglyceride(s)" ("TGs"), as used herein, incorporates its common usage. TGs consist of three fatty acid molecules esterified to a glycerol molecule and serve to store fatty acids which are used by muscle cells for energy production or are taken up and stored in adipose tissue. 10079] Because cholesterol and TGs are water insoluble, they must be packaged in special molecular complexes known as "lipoproteins" in order to be transported in the plasma. Lipoproteins can accumulate in the plasma due to overproduction and/or deficient removal. There are at least five distinct lipoproteins differing in size, composition, density, and function. In the cells of the small of the intestine, dietary lipids are packaged into large lipoprotein complexes called "chylomicrons", which have a high TG and low-cholesterol content. In the liver, TG and cholesterol esters are packaged and released into plasma as TG-rich lipoprotein called very low density lipoprotein ("VLDL"), whose primary function is the endogenous transport of TGs made in the liver or released by adipose tissue. Through enzymatic action, VLDL can be either reduced and taken up by the liver, or transformed into intermediate density lipoprotein ("IDL"). IDL, is in turn, either taken up by the liver, or is further modified to form the low density lipoprotein ("LDL"). LDL is either taken up and broken down by the liver, or is taken up by extrahepatic tissue. High density lipoprotein ("HDL") helps remove cholesterol from peripheral tissues in a process called reverse cholesterol transport, [0080] The term "dyslipidemia" refers to abnormal levels of lipoproteins in blood plasma including both depressed and/or elevated levels of lipoproteins (e.g., elevated levels of LDL, VLDL and depressed levels of HDL). 10081] Exemplary Primary Hyperlipidemia include, but are not limited to, the following: (0082] (1) Familial Hyperchylomicronemia, a rare genetic disorder which causes a deficiency in an enzyme, LIP Hpase, that breaks down fat molecules. The LP lipase deficiency can cause the accumulation of large quantities of fat or lipoproteins in the blood; [0083] (2) Familial Hypercholesterolemia, a relatively common genetic disorder caused where the underlying defect is a series of mutations in the LDL receptor gene that result in malfunctioning LDL receptors and/or absence of the LDL receptors. This brings about ineffective clearance of LDL by the LDL receptors resulting in elevated LDL and total cholesterol levels in the plasma; [0084] (3) Familial Combined Hyperlipidemia, also known as multiple lipoprotein-type hyperlipidemia; an inherited diso rder where patients and their affected first-degree relatives can at various times manifest high cholesterol and high triglycerides. Levels of HDL cholesterol are often moderately decreased; [0085J (4) Familial Defective Apolipoprotein B-100 is a relatively common autosomal dominant genetic abnormality. The defect is caused by a single nucleotide mutation that produces a substitution of glutamine for arginine which can cause reduced affinity of LDL particles for the LDL receptor. Consequently, this can cause high plasma LDL and total cholesterol levels; [0086] (5) Familial Dysbetaliproteinemia, also referred to as Type III Hyperlipoproteinemia, is an unc( >mmon inherited disorder resulting in moderate to severe elevations of sevum TG and chol esterol levels with abnormal apolipoprotein E function. HDL levels are usually normal; and [0087] (6) Familial Hypertriglyceridemia, is a common inherited disorder in which the concentration of plasma VLDL is elevated. This can cause mild to moderately elevated triglyceride levels (and usually not cholesterol levels) and can often be associated with low plasma HDL levels. [0088] Risk factors in exemplary Secondary Hyperlipidemia include, but are not limited to, the following: (1) disease risk factors, such as a history of Type 1 diabetes, Type 2 diabetes, Cushing's syndrome, hypothroidism and certain types of renal failure; (2) drug risk factors, which include, birth control pills; hormones, such as estrogen, and corticosteroids; certain diuretics; and various 0 blockers; (3) dietary risk factors include dietary fat intake per total calories greater than 40%; saturated fat intake per total calories greater than 10%; cholesterol intake greater than 300 mg per day; habitual and excessive alcohol use; and obesity. [0089] The terms "obese" and "obesity" refers to, according to the World Health Organization, a Body Mass Index (BMI) greater than 27.8 kg/m2 for men and 27,3 kg/m2 for women (BMI equals weight (kg)/height (m2). Obesity is linked to a variety of medical conditions including diabetes and hyperlipidemia. Obesity is also a known risk factor for the development of Type 2 diabetes (See, e.g., Barrett-Conner, E., Epidemol. Rev, (1989) 11: 172-181; and Knowler, et al.,^m../. Clin. Nutr. (1991) 53:1543-1551). [0090] The terms "optional" or "optionally" as used throughout the specification means that the subsequently described event or circumstance may but need not occur, and that the description includes instances where the event or circumstance occurs and instances in which it does not. For example, "heteroeyclo group optionally mono- or di- substituted with an alkyl group" means that the alkyl may but need not be present, and the description includes situations where the heterocy -'o group is mono- or disubstituted with an alkyl group and situations where the heteroeyclo group is not substituted with the alkyl group. General [0091] The present invention derives from the discovery that compounds of Formula la or Ib are useful in treating or controlling a number of diseases associated with glucose metabolism, lipid rnetuboUsm and insulin secretion. More particularly, the compounds of the invention aie useful in treating insulin resistance, diabetes, hyperinsulinemia, hyperlipidemia, hyperurit omia and obesity. Without intending to be bound by theory, it is considered that the compounds of Formula la or Ib operate via modulation of receptor interactions associated with o ne or more isoforms of PPAR. As a result, the compounds will likely have utility in treating other diseases states or conditions associated with PPAR. Compounds. [00-92] In one aspect, the present invention provides compounds having the formula: (Figure Remove) in which the letter X is selected from O, S, SO, SO2 and NR, wherein R is H, (Ci-Cg)alkyl, COR", COOR" and CONRaRb wherein Ra and Rb are each independently selected from H and (Ci-C8)alkyl; the letter Y represents CH2ORC, CO2RC, CHO, CONRcRm, CH(=NRC), CH(=NORC) or a carboxylic acid surrogate, wherein Rc is selected from H, (Ci-Cg)alkyl, (C3-C8)alkenyl, (C3-C8)alkynyl, (CrC/.)c' doalkyl, (C4-C8)cycloalkyl-alkyl, aryl, aryl(Ci-C8)alkyl and (CrC8)alkylene-Z, wherein Z is selected from CORd, COORd, NRdRe, NRdCONR*Rf, NRdCORc, NRdCOOR(' arid [00931 HAr repre.soi 11 s a heteroaryl moiety, optionally substituted with from one to three substituents independently selected from halogen, hydroxy, (Ci-Cs^lkyl, aryl(Ci-Cg)alkyl, (Ci-Cg)alkoxy, (( rC8)alkenyl, (C2-C8)alkynyl, (CrC7)cycloalkyl, (C4-C8)cycloalkyl-alkyl, (Ci-CgJheteroiilkyl, (C2-C5)heterocyclyl, aryl, heteroaryl, aryloxy, heterosubstituted(C3-C?)cycloalky I, hetei oalkyl substituted (C3-C7)cycloalkyl, (Ci-C8)haloalkyl, O(Ci-C8)haloalkyl, nitro, cyano, C02Rg, COR8, NR8Rh, S(O)qRg, S02NRBRh, NRgCONRhRj, NRgCORh, NR8COORh and CONR6Rh, wherein Rg, Rh and Rj are each independently selected from H and (Ci-Cg)alkyl, or optionally two of RB, Rh and R1 when attached to the same nitrogen atom are combined to form a five- or six-membered ring, and the subscript q is an integer of from 0 to 2. [0094] A variety of heteroaryl groups provide compounds having the desired activity. In particular, the heteroaryl groups can be monocyclic or fused bicyclic heteroaryl groups. More particularly, one group of suitable monocyclic heteroaryl groups are provided in Figure 1 A. In this Figure, the line extending from the ring indicates the point of attachment to the remainder of the compound and can be made through any available valence on the ring. Other examples of heteroaryl groups are provided in Figure IB, which illustrates preferred ftised-bicyclic heteroaryl groups, wherein attachment to the remainder of the compound can take place through an available valence on either ring. [0095] Returning to Formula la or Ib, the subscripts m and p indicate the presence of substituents on their repective rings, wherein each substituted present can be the same or different from any other substituent. More particularly, the subscript m is an integer of from 0 to 4, and the subscript p is an integer of from 0 to 3. More preferably the subscript m is an integer of from 0 to 3, and the subscript p is an integer of from 1 to 3. Still more preferably, ic subscript m is 0, 1, 2 or 3 and the subscript p is 1 or 2. 0096] Each R1 and R * represents a substituent independently selected from halogen, iydroxy, (C,-C8)alkyl, (C2-C8)alkeiiyl, (C2-C8)alkynyl, (Ci-C8)alkoxy, (C3-C7)cycloalkyl, C4-C8)cycloalkyl-alkyl, (C,-Q)haloalkyl, (Ci-C8)heteroalkyl, (C2-C5)heterocyclyl, ieterosubstituted(CrC7)cycloalkyl, heteroalkyl substituted (Cs-CvXycloalkyl, 0(Ci-:8)haloalkyl, nitro, cyano, phony', O-phenyl, NRj-phenyl, S(0)r-phenyl, CORj, COORj, s!RJRk, S(0)rRj, SO2NRJRk, NRjCONRkR', NRjCORk, NRjCOORk and CONRjRk wherein the )henyl ring is optionally substituted and Rj, Rk and R1 are each independently selected from Hi, (Ci-Cg)alkyl and (Ci-Cg)haloalikyl, or optionally two of Rj ,Rk and R1 when attached to the >ame nitrogen atom are combined to form a five- or six-membered ring, and the subscript r is an integer of from 0 to 2. 1 he. subscript m is an integer of from 0 to 4 and the subscript p is an integer of from 0 to 3. [0097] The symbol R2 represents a member selected from H, (CrC8)alkyl, (Ci-Cg)haloalkyl, aryl(Ci-CY)alkyl ami (Ci-C4)alkylene-Z, wherein Z is as defined above. [0098] In addition to compounds having formula la or Ib above, the present invention further includes all salts thereof, and particularly, pharmaceutically acceptable salts thereof. Still further, the invention includes compounds that are single isomers of the above formula (e.g., single enantiomers of compounds having a single chiral center), as well as prodrug forms thereof. [0099] In certain preferred embodiments, Y is CH2ORC, CO2RC, a carboxylic acid surrogate or CHO. Preferred carboxylic acid surrogates included tetrazol-5-yl and the group CONRcRm wherein Rm is SO2R". Still more preferably, the carboxylic acid surrogate is tetrazol-5-yl or CONHSOaR". A further preferred group of embodiments are those in which Y is CO2RC, a carboxylic acid surrogate or CHjOR0. (Figure Remove) [0100] A number of groups of embodiments are preferred and are set forth below. [0101] In a first group of embodiments, Y is CO2RC, a carboxylic acid surrogate (preferably those provided above) or CHaOR0; HAr is a fused bicyclic heteroaryl moiety, wherein each of the HAr groups is optionally substituted with from one to three substituents independently selected from the group consisting of halogen, (Ci-C4)alkyl, (C|-C4)haloalkyl, (Q-Cg)heteroalkyl (Ci-C4)alkoxy, 0(Ct-C4)haloalkyl, aryl(Ci-C4)alkyl, aryl(Ci-C4)haloalkyl, aryl, heteroaryl, aryloxy, nitro, cyano, CO2R8, CORe and CONR8Rh. Still further preferred, within this group of embodiments, are compounds wherein X is O, S or NH, with compounds in which R2 is H, CHj or CFa being further preferred. Even further preferred are those compounds wherein HAr is attached to the 2- or 3-position of the ring bearing X and is selected from: (Figure Remove) wherein each of the HAr groups is optionally substituted with from one to three substituents independently selected from halogen, (CrC4)alkyl, (Ci-C4)haloalkyl, (CrC8)heteroalkyl (d-C4)alkoxy, 0(CrC4)haloalkyl, aryl(C,-C4)alkyl, aryl(Ci-C4)haloalkyl, aryl, heteroaryl, aryloxy, nitro, cyano, C02Rg, CORg and CONRgRh, and wherein the wavy line indicates the point of attached to the ring bearing X through attachment to any available ring member in either ring of HAr. In preferred embodiments below, these substituents are provided as the group -(R4)s wherein each R4 is halogen, (C|-C4)alkyl, (Ci-C4)haloalkyl, (Ci-Cg)heteroalkyl (C,-C4)alkoxy, 0(C,-C4)haloalkyl, aryl(Ct-C4)alkyl, aryl(Ci-C4)haloalkyl, aryl, heteroaryl, aryloxy, nitro, cyano, CO2R8, COR8 and CONRBRh, and the subscipt s is an integer of from 0 to 3, indicating that the substituent is optional (s is 0) or present (s is 1, 2 or 3). When multiple substituents are present, each is selected independently of the others. [0102] Turning next to other substituents of formula la and Ib, each R3 is preferably, halogen, (C,-C4)alkyl, O(Ci-C4)alkyl, (C,-C4)haloalkyl, O(Ci-C4)haloalkyl, nitro, cyano, phenyl, 0-phenyl, NRj-phenyl or S(O)r-phenyl and each Rl is preferably halogen, (Cr C4)alkyl, O(CrC4)alkyl, (Ci-C4)haloalkyl, O(d-C4)haloalkyl, nitro, cyano, phenyl, O-phenyl, NR'-phenyl or S(O)r-phenyl. More preferably, the subscript m is is an integer of from 0 to 2; each R3 is independently selected from halogen, (d-C4)alkyl, 0(C|-C4)alkyl, (Ci-C4)haloalkyl, O(Ci-C4)haloalkyl, nitro, cyano, phenyl, Ophenyl, NRj-phenyl or S(0)r-phenyl; and the subscript p is an integer of from 0 to 2, with R1 being independently selected from halogen, (C|-C4)alkyl, O(C|-C4)alkyl, (C:rC4)haloalkyl, 0(C|-Q)haloalkyl, nitro, cyano, phenyl, 0-phenyl, NRJ-phenyl or S(O)r-phenyl. [0103] In a particularly preferred group of embodiments, the compounds have a formula selected from: (Figure Remove) wherein the subscrip i m is an integer of from 0 to 2, the subscript p is an integer of from 0 to 2, and R1 and R! une each independently selected from the group consisting of halogen, (Q-C4)alkyl, (Ci-C4):i1koxy, (CrC4)halo'alkyl, 0(Ci-C4)haloalkyl, nitro, cyano, phenyl, O-phenyl,NRj-phenyl and S(O)r-phenyl; and Rn is (CrC8)alkyl, (Ci-C8)haloalkyl, aryl(Ci-Cg)alkyl, (Ci-C8)heteroalkyl, aryl, IvtHeroaryl, (d-Cg)alkoxy, aryloxy, alkylamino, dialkylamino, arylamino, diarylamii 10, haloalkylamino and di(haloalkyl)amino. 0104] Still further preferred are those embodiments in which HAr is selected from (Figure Remove) wherein each of the HAr groups is optionally substituted with from one to three substituents independently selected from halogen, (Ci-C,)alkyl, (d-C4)alkoxy, (CrC4)haloalkyl, 0(Cr C4)haloalkyl, nitro, cyano, CO2R8, CORE and CONR8Rh. [0105] Even further preferred are those embodiments in which HAr is selected from (Figure Remove) when ",.; each of the HAr groups is optionally substituted with from one to three substituents in(' .- i ndently selected from the group consisting of halogen, (Ci-C4)alkyl, (C|-C4)alkoxy, ' V. C4)haloalkyl, 0(CrC4)haloalkyl, nitro, cyano, CO2R8, CORg and CONR8Rh. In certain i.ost preferred embodiments, HAr is an optionally substituted 2-benzoxazolyl; R2 is H or CHj; the subscript m is 0 or 1, and p is 1 or 2; and R1 and R3 are each independently selected from the group consisting of halogen, (Ci-C4)alkyl, (Q-C^alkoxy, (Ci-C4)haloalkyl, O(C|-C4)haloalkyl, nitro, cyano, C02Rg, COR8 and CONRgRh. In other most preferred embodiments, HAr is an optionally substituted 2-benzothiazolyl; R2 is H or CHj; the subscript m is 0 or 1, and p is 1 or 2; and R1 and R3 are each independently selected from the group consisting of halogen, (Ci-C4)alkyl, (d-C4)alkoxy, (Ci-C4)haloalkyl, O(Cp C4)haloalkyl, nitro, cyano, C02R8, COR8 and CONRBRh. In still other most preferred embodiments, HAr is an optionally substituted 2-benzotriazolyl; R2 is H or CHs; the subscript ra is 0 or 1, and p is 1 or 2; and R1 and R3 are each independently selected from the group consisting of halogen, (CrC4)alkyl, (Ci-C4)alkoxy, (C|-C4)haloalkyl, O(d-C4)haloalkyl, litro, cyano, CO2Rg, COR6 and CONReRh. [0106] In a second group of embodiments, Y is COaR0, a carboxylic acid surrogate or CHaOR0; HAr is a monocyclic heteroaryl moiety, wherein each of the HAr groups is aptionally substituted with from one to three substituents independently selected from halogen, (C,-C4)alkyl, (C,-C8)heteroalkyl, (C,-C4)alkoxy, (C1-C4)haloalkyl, 0(d-C4)haloalkyl, aryl(Ci-C4)alkyl, aryl, heteroaryl, nitro, cyano, C02Rg, COR8 and CONRgRh, In preferred embodiments be low, these substituents are provided as the group -(R4)5 wherein each R4 is selected from the group of substituents provided above, and the subscript s is an integer of from 0 to 3, indicating that the substituent is absent (s is 0) or present (s is 1, 2 or 3). When multiple substil uents are present, each is selected independently of the others. Still further preferred, within this group of embodiments, are compounds wherein X is 0, S or NH, with compounds in which R2 is H, CHj or CFa being further preferred. Even further preferred are those compounds wherein HAr is attached to the 2- or 3-position of the phenyl ring bearing X and is selected from the group consisting of (Figure Remove) whereir't each of said HAr groups is optionally substituted with from one to three substituents independently selected from the group consisting of halogen, (Ci-C4)alkyl, (Ci-Cgjheteroalkyl, (Ci-C4)alkoxy, (d-C4)haloalkyl, 0(Ci-C4)haloalkyl, aryl(Ci-C4)alkyl, aryl, heteroaryl, nitro, cyano, COjR8, COR8 and CONR8Rh, and the wavy line indicates the attachment to the ring bearing X. That is, HAr is preferably attached to a carbon atom directly adjacent to the sp2-carbon bearing X (an ort/io-position), or is attached to a carbon atom one place removed from the sp2-carbon bearing X (a meto-position). [0107J Turning next to other substituents of formula la and Ib, each R3 is preferably, halogen, (Ci-C4)alkyl, O(Ci-C4)alkyl, (CrC4)haloalkyl, O(C|-C4)haloalkyl, nitro, cyano, phenyl, O-phenyl, NRj-phenyl or S(0)r-phenyl and each R1 is preferably halogen, (Ci-C4)alkyl, O(CrC4)alkyl, (CrC4)haloalkyl, O(Ci-C4)haloalkyl, nitro, cyano, phenyl, O-phenyl, NR*-phenyl or S(0)r-phenyl. More preferably, the subscript m is is an integer of from 0 to 2; each R3 is independently selected from halogen, (Ci-C4)alkyl, O(Ci-C4)alkyl, (C|-C4)haloalkyl, O(Ci-C4)haloalkyl, nitro, cyano, phenyl, O-phenyl, NRj-phenyl or S(O)r-phenyl; and the subscript p is an integer of from 0 to 2, with R1 being independently selected from halogen, (Ci-C4)alkyl, O(C|-C4)alkyl, (CrC4)haloalkyl, 0(CrC4)haloalkyl, nitro, cyano, phenyl, O-phenyl, NT^-phenyl or S(O)r-phenyl. (0108) In a particularly preferred group of embodiments, the compounds have a formula selected from: (Figure Remove) wherein the subscript m is an integer of from 0 to 2, the subscript p is an integer of from 0 to 2, and R1 and R3 are each independently selected from the group consisting of halogen, (C|-C4)alkyl, (Ci-C4)alkoxy, (CrC4)haloalkyl, O(CrC4)haloalkyl, nitro, cyano, phenyl, 0-phenyl, NRJ-phenyl and S(O)rphenyl; and Rn is (C,-C8)alkyl, (Ci-C8)haloalkyl, aryl(C,-Cg)alkyl, (Ci-Cg)heteroalkyl, aryl, heteroaryl, (Ci-Cg)alkoxy, aryloxy, alkylamino, dialkylamino, arylamino, diarylamino, haloalkylamino and di(haloalkyl)amino. [0109] Still further preferred are those embodiments in which HAr is selected from wherein each of the HAr groups is optionally substituted with from one to three substituents independently selected from halogen, (C|-C4)alkyl, (Ci-Cg)heteroalkyl, (CrC4)alkoxy, (Ci-C4)haloalkyl, O(C,-C4)haloalkyl, aryl(CrC4)alkyl, aryl, heteroaryl, nitro, cyano, CO2RS, COR8 and CONR8Rh. [01101 Even further preferred are those embodiments in which HAr is selected from the group consisting of (Figure Remove) wherein eat h of the HAr groups is optionally substituted with from one to three substituents independently selected from halogen, (C|-C4)alkyl, (Ci-Cg)heteroalkyl, (Ci-C4)alkoxy, (C|-C4)haloalkyl, O(Ci-C4)half.alkyl, aryl(C|-C4)alkyl, aryl, heteroaryl, nitro, cyano, COjR8, CORg nad CONR8Rh. In the most preferred embodiments, R1 and R3 are each independently seleckM from F, Cl, Br, (C,-C4)alkyl, (CrC4)alkoxy, (CrC4)haloalkyl, O(C,-C4)haloalkyl, CN, NOj and phenyl. Within this most preferred group of embodiments, certain optionally substituted HAr groups are further preferred. In one of these groups HAr is optionally substituted 2-, 4- or 5-thiazolyl wherein the thiazolyl is optionally substituted with from one to two substituents selected from the group consisting of F, Cl, Br, (Ci-C4)alkyl, aryl(C|-O)alkyl, (CrC4)alkoxy, (CrC4)haloalkyl, 0(Ci-C4)haloalkyl, CN and phenyl; R2 is H or CH3; the subscript m is 0 or 1 and p is 1 or 2; and R1 and R3 are each independently selected from the group consisting of F, Cl, Br, (Cl-C4)alkyl, (CrC4)alkoxy, (C,-C4)haloalkyl, O(C,-C4)haloalkyl, CN, NC>2 and phenyl. In another of these groups, HAr is selected from the group consisting of optionally substituted 1, 3, 4 or 5-pyrazolyl wherein the pyrazolyl is optionally substituted with from one to two substituents selected from the group consisting of F, Cl, Br, (CrC4)alkyl, aryl(CrC4)alkyl, (Ci-C4)alkoxy, (d-C4)haloalkyl, O(Cr C4)haloalkyl, CN and phenyl; R2 is H or CH3; the subscript m is 0 or 1 and p is 1 or 2; and R1 and R3 are each independently selected from the group consisting of F, Cl, Br, (Ci-C4)alkyl, (C,-C4)alkoxy, (Ci-C4)haloalkyl, O(CrC4)haloalkyl, CN, NO2 and phenyl. In still other groups, HAr is optionally substituted 2-, 4- or 5-oxazolyl wherein the oxazolyl is optionally substituted with from one to two substituents selected from the group consisting of F, Cl, Br, (CrC4)alkyl, aryl(Ci-C4)alkyl, (C,-C4)alkoxy, (CrC4)haloalkyl, O(d-C4)haloalkyl, CN and phenyl; R2 is H or CH3; the subscript m is 0 or 1 and p is 1 or 2; and R1 and R3 are each independently selected from the group consisting of F, Cl, Br, (Ci-C4)alkyl, (C|-C4)alkoxy, (C,-C4)haloalkyl, O(C,-C4)haloalkyl, CN, NO2 and phenyl. [0111] Other preferred groups of embodiments are provided by each of formula Ha through Ham, in Figures 2, 3, and 4A, wherein each of Rc, R1, R2, R3, R4, R5 and the subscripts m, p and s have the meanings provided above with regard to their most general embodiments. The group provided as R which is attached to nitrogen in certain formulae is intended to be H or another R4 moiety that can he the same or different from the remaining R4 moieties. Preferred members l Rc, R1, R3, R4, and the subscripts m, p and s are those that are provided above as preferred for each of these groups with respect to the fused bicyclic HAr moieties. Further prefe; i,ed for each of Ha through Ham are those compounds in which p is 0,1 or 2; m is 0,1, or ?, each R1 and R3 when present is selected from F, Cl, Br, (Ci-C4)alkoxy, (Cr C4)alkyl (C,-C4)haloa\kyl, O(CrC4)haloalkyl, CN and N02; s is 0 or 1; Rc is H or (Cr C4)alV yl; R2 is H, CH3 or CF3. In the most preferred embodiments for each of Ha through Ham., p is 1 or 2, more preferably 1; m is 0,1, or 2, more preferably 0 or 1; each R1 and R3 wl.cn present is selected from F, Cl, Br, CF3 and OCH3; s is 0 or 1; Rc is H; R2 is H or CH3. V'l 12] Still other preferred groups of embodiments are provided by each of formula Han through Ilaz, in Figure 4B, wherein each of R1, R2, R3, R4 Rn and the subscripts m, p and s have the meanings provided above with regard to their most general embodiments. Preferred members of R1, R2, R3, R4, Rn and the subscripts m, p and s are those that are provided above for each of these groups with respect to the fused bicyclic HAr moieties. Further preferred for each of Han through Ilaz are those compounds in which p is 0,1 or 2; m is 0, 1, or 2; each I1 and R3 when present is selected from F, Cl, Br, (Ci-C4)alkoxy, (C]-C4)alkyl, :4)haloalkyl, (Ci~C4)haloalkyl ,CN and N02; Rn is (Ci-C8)alkyl, (Ci-C8)haloalkyl, aryl, ilkylamino, dialkylamino or arylamino; s is 0 or 1; R2 is H, CH3 or CF3. In the most ^referred embodiments for each of Han through Ilaz, p is 1 or 2, more preferably 1; m is 0,1, 3r 2, more preferably 0 or 1; each R1 and R3 when present is selected from F, Cl, Br, CF3 and 3CH3;sisOorI;R2 isHorCH3. [0113] Still other preferred groups of embodiments are those having attached monocyclic heteroaryl groups as HAr in formula la and Ib and are provided by each of formula Ilia through IIIx, in Figures 5A and 5B, when i each of Rc, R1, R2, R3, R4, and the subscripts m, p and s have the meanings provided above with regard to their most general embodiments. The group provided as R which is attached to nitrogen in certain formulae is intended to be H or another R4 moiety that can be the same or different from the remaining R4 moieties. Preferred members of Rc, R1, R2, F ', R4, and the subscripts m, p and s are those that are provided above for each of these tgroups with respect to monocyclic HAr moieties. Further preferred for each of IHa through lllx are those compounds in which p is 0, 1 or 2; m is 0,1, or 2; each R1 and R3 when present is selected from F, Cl, Br, (C|-C4)alkoxy, (Ci-C4)alkyl, O(C|-C4)haloalkyl, (Ci -C.0haloat.kyl, CN and NO2; s is 0, 1 or 2; R° is H or (C,-C4)alkyl; R2 is H, CH3 or CF3. In the most preferred embodiments for each of Ilia through IIIx, p is 1 or 2, more preferably 1; mis 0, 1, or 2, more preferably 0 or 1; each R1 and R3 when present is selected from F, Cl, Br, CI 3 and OCH3; s is 0,1 or 2; Rc is H; R2 is H or CH3. (0114] Still other preferred groups of embodiments are provided by each of formula Illaa through Illah in Figure 5C, wherein each of R1, R2, R3, R4 R" and the subscripts m, p and s have the meanings provided above with regard to their most general embodiments. Preferred members of R1, R2, R\ R4, Rn and the subscripts m, p and s are those that are provided above for each of these groups with respect to the monocyclic HAr moieties. Further preferred for euch of Illaa through Illah are those compounds in which p is 0, 1 or 2; m is 0,1, or 2; each R1 and R3 when present is selected from F, Cl, Br, (Ci-C4)alkoxy, (C]-C4)alkyl, O(Cj-C«)haloalkyl, (C,-C4)haloalkyl, CN and N02; Rn is (CrCg)alkyl, (Ci-Cg)haloalkyl, aryl, alkylamino, dialkylamino, arylamino and diarylamino; s is 0,1 or 2; and R is H, CH3 or CF3. hi the most preferred embodiments for each of Illaa through Illah, p is 1 or 2, more preferably 1; m is 0, 1, or 2, more preferably 0 or I; each R1 and R3 when present is selected from F, Cl, Br, CF3 and OCH3; s is 0, 1 or 2; and R2 is H or CH3. [0115] Still other preferred groups of embodiments are provided in the Examples and Tables below. General Synthetic Routes to Compounds of the Invention [0116] The compounds of the present invention can be prepared using methods generally outlined in Schemes 1-5. (Figure Remove) [0117] According to Scheme 1, sa.'licylic acids of formula i (either commercially available or prepared according to known m.ethods) are condensed with suitably substituted 2-aminophenols (ii) to provide a 2 (benzoxazol-2-yl)phenol (Hi). Treatment of iii with a suitably substituted ethyl 2-brornophenylacetate (vi-a), generally in the presence of a base such as potassium carbonate, provides the target compound vii. Alternatively, 2-fluorobenzoic acids (iv) can be converted to the corresponding derivatives v which can then be converted to iii and carried on through the scheme as noted, or, in certain embodiments, compounds of formula v can be converted d irectly into target compounds vii using 2-hydroxyphenylacet ic acid derivatives (vi-b). The latter route is particularly useful for the compounds of formula vii in which R1 substituents increase the reactivity of the ring toward fluorine displacement. Additionally, in the above Scheme as well as in Formulae II and III, below, each R4 (the subscript s being an integer of from 0 to 4), is meant to include any of the HAr substituents provided above. [0118] Structural isomers, having the benzoxazolyl ring attached at either the 3-position or the 4-position relative to the phenolic hydroxy group in compound iii can be prepared from the corresponding 3-hydroxybenzoic acids and 4-hydroxybenzoic acids. (0119} In a similar manner, compounds of formula la wherein X is NH can be prepared as follows. (Figure Remove) (0120] Here, a 2-fluo robenzoic acid or benzoyl chloride (viii) serves as the starting material. The acid ch ioride is treated with 2-aminophenols (ii) to provide substituted aryl fluorides, ix. Treatment of ix with the suitably substituted ethyl 2-aminophenylacetate (vi-c) provides the target compound x. [0121] Still further, the general schemes outlined in Scheme 1 and Scheme 2 can be used to prepare compounds of Formula la in which HAr is benzothiazolyl. To obtain these compounds, the 2-aminophenols (ii) are replaced by the corresponding 2-aminothiophenols. More specific details are provided in the examples below. [0122] Preparation of compounds of Formula la in which HAr is a suitably substituted benzimidazole can be prepared according to the general methods outlined in Scheme 3. (Figure Remove) [0123] In Scheme 3, salio > , acid derivatives of formula i are condensed with N-methyl-l,2-phenyleny hydrogen or by other (Ci-Cg)alkyl groups. [0124] In each of Schemes 1, 2 and 3, the position of the heteroaryl ring portion can be changed depending on the starting benzoic acids i and viii. [0125] Related compounds can be prepared in a similar manner beginning with, for example, appropriately substituted 2-(5-isoxazolyl)phenols, many of which are available from commercial sources or can be prepared according to literature methods (see Scheme 4). (Figure Remove) [0126) Similarly, compounds of Formula la in which HAr is a pyrazolyl group can be prepared from the corresponding pyrazolylphenols (see Scheme 5). (Figure Remove) [0127J In each of Scheme 1-5, reaction conditions (e.g., amounts of reactants, solvents, temperatures and wotkup conditions) can be selected using the Examples below as a guide. Pre; nration of alcohols, esters and aldehydes 10128] The above general synthesis schemes are provided to illustrate the prepared of compounds of Formula la or !b in which Y is a carboxylic acid or ester. Conversion of each of these groups in Conversion of carboxylic acids into aldehydes, carbinols and carbinol esters, [0129] The carboxylic acids of this invention can be converted into the corresponding aldehydes, carbinols and carbinol esters by a number of methods, including the routes A-E shown in Scheme 6. The method to be used in a given case depends on the nature of R, and the substituents thereon. A variety of useful methods are described in Larock, COMPREHENSIVE ORGANIC TRANSFORMATIONS, VCH Publishers Inc. New York (1989). In particular, methods are described for converting acyl chlorides 2 to aldehydes 3 (p 620), aldehydes 3 to carbinols 4 (p 528ff), esters 5 to aldehydes 3 (p 621), esters 5 to carbinols 4 (p 549), carboxylic acids 1 to carbinols 4 (p 548), carbinols 4 to aldehydes 3 (p 604) and carbinols 4 to esters 6 (p 966). [0130] In method A, Scheme 6, the carboxylic acid 1 is first converted into the corresponding acid chloride 2. This transformation is effected by reacting the acid 1 with oxalyl chloride, phosphorus pentachloridc, or, preferably, thionyl chloride. The reaction is conducted in an aprotic solvent such as dichloi muethane, tetrahydrofuran or, preferably, 1,2-dichloroethane. The acid chloride 2 is then converted into the aldehyde 3 by chemical reduction, such as by the use of sodium borohydride in DMF at -70°C, as described in Tetrahedron Lett. 22:11 (1981), or, more pre ferably by hydrogenation using 5% palladium on barium sulfate as catalyst (see, for example., J. Amer. Chem. Soc., 108:2608 (1986)). The reaction is conducted in an iiprotic solvent such as toluene or, preferably, xylene. The aldehyde 3 is converted into i!x; carbinol 4 by reduction, for example by reaction with 9-BBN, lithium aluminum in'ertiarybutoxy hydride, or more preferably sodium borohydride, (see, J. Amer. Chem. Soc "' I -.122 (1949)). The reaction is conducted in a protic solvent such as ethanol, or preferably, isopropanol. (01311 In methf i B, Scheme 6, the carboxylic acid is first converted into an ester 5, in which R! is low |0131 \ The ester 5 i s converted into the carbinol 4 by reduction with lithium aluminum hydride or, preferably, with lithium borohydride (see, J. Amer. Chem. Soc., 109:1186 (1987)). I he reaction is conducted in an ethereal solvent such as dioxan or, preferably, tetrahydn in ran. [0133] In method C, Scheme 6, the carboxylic acid 1 is converted into the carbinol 4. This conversion is effected by reading the carboxylic acid with a reducing agent such as lithium aluminum hydride or, preferably, with diborane, as described in ORGANIC SYNTHESES, 64:104 (1985). The reaction is conducted in an ethereal solvent such as dioxan or, preferably, tetrahydrofuran. [0134J In method D, Scheme 6, the carbinol 4 is converted into the aldehyde 3. This conversion is effected by reacting the carbinol with an oxidizing agent such as dicyclohexylcarbodiimide/dimethylsulfoxide, or, preferably, with pyridinium chlorochromate, as described in Synthesis, ?45 (1982). The reaction is conducted in an aprotic solvent such as dichloromethane or, preferably, 1,2-dichloroethane, optionally in the presence of celite, as described in J. Org. Chem., 50:2626 (1985). [0135] In method E, Scheme 6, the carbinol 4 is converted into the ester 6. This transformation is effected by an esterification reaction, for example by reacting the carbinol 4 with a carboxylic anhydride (R2CO)20, or, preferably, with an acyl chloride R2COC1. The reaction is conducted in an aprotic solvent such as dichloromethane or, preferably, tetrahydrofuran, in the presence of an organic base such as triethylamine or, preferably, pyridine. (Figure Remove) Resolution ofisomers (enantiomers) [0136] For many compounds of the present invention, a single chiral center is present (at the carbon atom bearing R2), resulting in racemic mixtures of enantiomers. As noted above, the present invention further includes compounds, compositions and methods wherein a single isomer (or single enantiomer) is provided or used. Methods of preparing chiral compounds are provided in the Examples. Alternatively, mixtures of enantiomers can be separated into their individual isomers via methods such as salt formation and crystallization with chiral bases, chiral chromatography (e.g., hplc using commercially available columns for chiral resolution) and via methods such as simulated moving bed chromatography (see, for example, U.S. Patent No. 5,518,625). [0137] In certain preferred embodiments of the invention, the (-)-isomer of the compound of formula la or Ib is used, which is sub" i initially free of its (-t-)-isomer. In this context, "substantially free" refers to a compound that is contaminated by less than about 20%, more preferably 10%, still more preferably '>%, even more preferably 2% and most preferably less than about 1% of the undesired isomer. In other preferred embodiments of the invention, the (-t-)-isomer of the compound of formula la or Ib is used, which is substantially free of its (-)-isomer. Prodrug forms of the Compounds of the Invention [0138] In some embodiments, the compounds of the invention are present in a prodrug form. In particular, the invention also provides, for example, compounds of Formula la or Ib in which Y is -CO2H which has been esterified to form -COjR", wherein R" is selected from alkyl, hetnoalkyl, aryl, heteroaryl, phenyl-lower alkyl, benzamido-lower alkyl, di-lower alkylanlino-lower alkyl, ureido-lower alkyl, N'-lower alkyl-ureido-lower alkyl, carbamoyl-lower alkyl, halophenoxy substituted lower alkyl and carbamoyl substituted phenyl. [0139] Examples of such R" groups include, without limitation, the following: C\-Cs alkyl, Ci-Cg-cyclic alkyl, C2-C5 alkenyl, and C2-C5 alkynyl, wherein the groups are optionally substituted with one or more halogen atoms; phenyl, naphthyl and pyridyl, wherein the groups are optionally substituted \vith one or more substituents selected from the group consisting of halo, C,-C4 alkyl, C,-C4 alkoxy, -NO2, -S(0)m,(Ci-Csalkyl), -OH, -NR3aR4a, ~C02R5a, -CONR3aR4a, ~NR3aCOR4a, -NR3aCONR3aR4a and -Cv,Fwl; -(CHR3a)R4a; -R5aOR3a; -R5a02CR6aNR3aR4a; -R8aCOR6a; -R7aNR3aCOR4a; -R7aNR3aR4a; -(CH2)01CH(R3a)(CH2)qt02CR9a;-(CH2)01CH(R3a)(CH2)qlNR4aCOR9a; -(CH2)olCH(R3a)(CH2)q,m4aCONR3aR4^-(CH2)0,CH(R3a)(CH2)qlNR4aCOOR10a; ~(CH2)o!CH(R3a)(CH2)qlNR4aS02R1 la; -(CHR3a)plCO2R!2a; -(CHR3a)pINR3aR4!1; -(CHR3a)s,CONR13aRHa Subscripts ml, ol, ql, si, tl, ul, vl and wl are integers as follows: ml is 0 to 2; ol and ql are 0 to 5; pi is 1 to 5; si is 1 to 3; t! is I to 5; ul is 0 to 1; vl is 1 to 3; and wl is 1 to (2vl + 1). R3i and R4a are independently H, CrC5 alkyl, phenyl or benzyl. R5a is H, C|-C5 alkyl or NR3aR4a, R6a is phenyl, naphthyl, pyridyl, mdazolyl, indoxyl, indolizinyl, oxazolyl, thiazolyl, thienyl, pyrimidyl, or 1-pynr/i >i , ! optionally substituted with one or more substituenls selected from the group consisting of halo, Ci-C4 alkyl, Ci-C4 alkoxy, -NO2, -S(0)m)(C,-C5alkyl), -OH, ~NR3aR4s, -C02R5a, -CONR3aR4a, -NR3aCOR4a, -NR3aCONR3aR4a and -CV]Fwi. R7 is a Ci-C8 saturated or unsaturated, straight-chain, branched or cyclic alkylene or a!k> lidene group optionally substituted with one or more groups selected from halo, hydro; y!, thiol, amino, monoalky! amino, dialkyl amino, acylamino, carboxyl, nlks Icarboxyl, acyl, aryl, aroyl, aralkyl, cyano, nitro, alkoxy, alkenyloxy, alkylcarbonyloxy avid arylcarbonyloxy. R8a is a Ci-Cg straight-chain or branched alkylene or alkyl id^ne optionally substituted with one or more groups selected from amino, monoalkyl amin \ dialk>'l amino, acylamino, hydroxyl, thiol, methylthiol, carboxyl and phenyl. R9a and Ru>a arc independently H, C\-Cs alkyl, optionally substituted with one or more groups consisting of Q-Cs alkoxy, aryl and heteroaryl, wherein the aryl is phenyl or naphthv i optionally substituted with one or more substituents selected from the group consisting of halo, C,-C. alkyl, C|-C4 alkoxy, -NO2, -S(O)mI(C,-C5alkyl), -OH, -NR3aR4a, -C'JiR5', -CONR3aR4?, -NfR3aCOR4a, -NR3aCONR3aR4a and -Cv!Fw!, and wherein the 1"? teroaryl is pyridyl optionally substituted with one or more substituents selected from the f ;roup consisting of halo, CrC4 alkyl, C1-C4 alkoxy, -N02, -S(O)ml(Ci-Csalkyl), -OH, -NR3aR4a, -C02R5a, -CONR3aR4a, -NR3aCOR4a, -NR3aCONR3aR4a and -Cv.Fwl. R1'3 is methyl or phenyl, wherein the phenyl is optionally substituted with methyl and/or -N02. Rl2a is H, C|-C5 alkyl, phenyl, benzyl, naphthyl or pyridyl, wherein the Ci-C5 alkyl, phenyl, naphthyl, benzyl and pyridyl are optionally substituted with one or more substituents selected from the group consisting of halo, CrC4 alkyl, d-C4 alkoxy, -N02, -S(O)mi(d-Csalkyl), -OH, -NR3aR4a, ~C02RSa, -CONR3aR4a, -NR3aCOR4a, -NR3aCONR3aR4a and -CviFwl. R13a md Rl4a are independently the following: alkyl, alkenyl, aryl, aralkyl or cycloalkyl, wherein he groups are optionally substituted with one or more substituents selected from the group insisting of halo, d-C4 alkyl, CrC4 alkoxy, -N02, -S(0)mi(CrC5alkyl), -OH, -NR3aR4a, -CO2Ria, -CONR3aR4a, -NR3aCOR4a, -NR3aCONR3aR4a, -CH2NR3aR4a, OOCR18a and -CviFwi; and wherein Rl3a and R14a are included as -(CHR3a)CONR13aR14a wherein NR13aR14a is (Figure Remove) [0140] R15a is CV|F« i or Ci-Cs alkyl, wherein CrC5 alkyl is optionally substituted with the following substituents. C\-C$ alkoxy; phenyl, optionally substituted with one or more substituents selected from the group consisting of halo, Ci-C4 alkyl, CpC4 alkoxy, -NO2, -S(0)m,(C,-C5alkyl), -OH, -NK3aR4a, -CO2R5a, -CONR3aR4a, -NR3aCOR4a, -NR3aCONR VaR4a and -CviFwl, benzyl, optionally substituted with one or more substituents selected frum the group consisting of halo, CpC4 alkyl, C|-C4 alkoxy, -N02, -S(O)mi(Cr C5alkyl), - OH, -NR3aR4a, -CO2R5a, -CONR3aR4a, -NR3aCOR4a, -NR3aCONR3aR4a and -CviFwi R16a is H, Ci-Cj alkyl or benzyl. R17a is CrC5 alkyl, C3-C8 cyclic alkyl, phenyl or benzyl R18a is H, alkyl, aryl, aralkyl or cycloalkyl, where the group is optionally substituted with one or more substituents selected from the group consisting of halo, Ci-C4 alkyl, C|-C4 alkoxy, -NO2, -S(0)m,(CrC5alkyl), -OH, -Nft3aR4a, -C02R5a, -CONR3aR4a, -NR3aCOR4a, -N!K.laCONR3aR4a and - CvlFwl. Pharmaceutical Compositions and Methods of Treating Diseases and Conditions [0141 ] In accordance with the present invention, a therapeutically effective amount of a compound of Formula la or Ib can be used for the preparation of a pharmaceutical composition useful for treating diabetes, treating hyperlipidemia, treating hyperuricemia, treating obesity, lowering triglyceride levels, lowering cholesterol levels, raising the plasma level of high density lipoprotein, and for treating, preventing or reducing the risk of developing atherosclerosis. [0142] The compositions of the invention can include compounds of Formula la or Ib, pharmaceutically acceptable salts thereof, or a hydrolyzable precursor thereof. In general, the ompound is mixed with suitable earners or excipient(s) in a therapeutically effective imount. By a "therapeutically effective dose", "therapeutically effective amount", or, nterchangeably, "pharmacologically acceptable dose" or "pharmacologically acceptable imount", it is meant that a sufficieni amount of the compound of the present invention and a )harmaceutically acceptable carriei, will be present in order to achieve a desired result, e.g., alleviating a symptom or complies lion of Type 2 diabetes. [0143] The compounds of Form ula la or Ib that are used in the methods of the present invention can be incorporated into a variety of formulations for therapeutic administration. More particularly, the compounds of Fonnula la or Ib can be formulated into pharmaceutical compositions by combination w ith appropriate, pharmaceutically acceptable carriers or diluents, and can be formulated into preparations in solid, semi-solid, liquid or gaseous forms, such as tablets, capsules, pills, powders, granules, dragees, gels, slurries, ointments, solutions, suppositories, injections, inhalants and aerosols. As such, administration of the compounds can bo achieved in various ways, including oral, buccal, rectal, parenteral, intraperitoneal, intradermai, transdermal, intratracheal administration. Moreover, the compound can be administered in a local rather than systemic manner, in a depot or sustained release formulation. In addition, the compounds can be administered in a liposome. [0144] The compounds of Formula la or Ib can be formulated with common excipients, diluents or carriers, and compressed into tablets, or formulated as elixirs or solutions for convenient oral administration, or administered by the intramuscular or intravenous routes. The compounds can be administered transdermally, and can be formulated as sustained release dosage forms and the like. Compounds of Formula la or Ib can be administered alone, in combination with each other, or they can be used in combination with other known compounds (see Combination Therapy below). [0145J Suitable formulations for use in the present invention are found in Remington's Pharmaceutical Sciences (Mack Publishing Company (1985) Philadelphia, PA, 17th ed.), which is incorporated herein by reference. Moreover, for a brief review of methods for drug delivery, see, Langer, Science (1990) 249:1527-1533, which is incorporated herein by reference. The pharmaceutical compositions described herein can be manufactured in a manner that is known to those of skill in the art, i.e., by means of conventional mixing, dissolving, granulating, dragee-making, levigating, emulsifying, encapsulating, entrapping or lyophilizing processes. The following methods and excipients are merely exemplary and are in no way limiting. [0146] For injection, the c [0147] For oral administration, ihe compounds of Formula la or Ib can be formulated read' iy by combining with pharmaceutically acceptable carriers that are well known in the ai I Such carriers enable the com pounds to be formulated as tablets, pills, dragees, capsules, emu Isions, lipophilic and hydrophilic suspensions, liquids, gels, syrups, slurries, suspensions an^1 the like, for oral ingestion by a patient to be treated. Pharmaceutical preparations for oral use can be obtained by mixing the compounds with a solid excipient, optionally grinding a resulting mixture, and processing the mixture of granules, after adding suitable auxiliaries, if desired, to obtain tablets or dragee cores. Suitable excipients are, in particular, fillers such as sugars, including lactose, sucrose, mannitol, or sorbitol; cellulose preparations such as, for example, maize starch, wheat starch, rice starch, potato starch, gelatin, gum tragacanth, methyl cellulose, hydroxypropylmethyl-cellulose, sodium carboxymethylcellulose, and/or polyvinylpyrrolidone (PVP). If desired, disintegrating agents can be added, such as the cross-linked polyvinyl pyrrolidone, agar, or alginic acid or a salt thereof such as sodium alginate. [0148J Dragee cores are provided with suitable coatings. For this purpose, concentrated sugar solutions can be used, which can optionally contain gum arabic, talc, polyvinyl pyrrolidone, carbopol gel, polyethylene glycol, and/or titanium dioxide, lacquer solutions, and suitable organic solvents or solvent mixtures. Dyestuffs or pigments can be added to the tablets or dragee coatings for identification or to characterize different combinations of active compound doses. [0149] Pharmaceutical preparations which can be used orally include push-fit capsules made of gelatin, as well as soft, sealed capsules made of gelatin and a plasticizer, such as glycerol or sorbitol. The push-fit capsules can contain the active ingredients in admixture with filler such as lactose, binders such as starches, and/or lubricants such as talc or magnesium stearate and, optionally, stabilizers. In soft capsules, the active compounds can be dissolved or suspended in suitable liquids, such as fatty oils, liquid paraffin, or liquid polyethylene glycols. In addition, stabilizers can be added. All formulations for oral administration should be in dosages suitable for such administration. (0150] For buccal administration, the compositions can take the form of tablets or lozenges formulated in conventional manner. [01511 For admins stration by inhalation, the compounds for use according to the present invention are conveniently delivered in the form of an aerosol spray presentation from pressurized packs or a nebulizer, with the use of a suitable propellant, e.g., dichlorodifiuoroniethane, trichlorofluoromethane, dichlorotetrafluoroethane, carbon dioxide or other suitable gas, or from propellant-free, dry-powder inhalers. In the case of a pressurized aerosol the dosage unit can be determined by providing a valve to deliver a meterecl amount. Capsules and cartridges of, e.g., gelatin for use in an inhaler or insufflator can be formulated containing a powder mix of the compound and a suitable powder base such as lactose or starch [0152] The compounds can be formulated for parenteral administration by injection, e.g., by bolus injection or continuous infusion. Formulations for injection can be presented in unit dosage form, [01531 Pharmaceutical formulations for parenteral administration include aqueous solutions of the active compounds in water-soluble form. Additionally, suspensions of the active compounds can be prepared as appropriate oily injection suspensions. Suitable lipophilic solvents or vehicles include fatty oils such as sesame oil, or synthetic fatty acid esters, such as ethyl oleate or triglycerides, or liposomes. Aqueous injection suspensions can contain substances which increase the viscosity of the suspension, such as sodium carboxymethyl cellulose, sorbitol, or dextran. Optionally, the suspension can also contain suitable stabilizers or agents which increase the solubility of the compounds to allow for the preparation of highly concentrated solutions. Alternatively, the active ingredient can be in powder form for constitution with a suitable vehicle, e.g., sterile pyrogen-free water, before use. (0154] The compounds can also be formulated in rectal compositions such as suppositories or retention enemas, e.g., containing conventional suppository bases such as cocoa butter, carbowaxes, polyethylene glycols or other glycerides, all of which melt at body temperature, yet are solidified at room temperature. [0155] In addition to the fonnu'iations described previously, the compounds can also be formulated as a depot preparation. Such long acting formulations can be administered by implantation (for example subcutaneously or intramuscularly) or by intramuscular injection. Thus, for example, the comsiounds can be formulated with suitable polymeric or hydrophobic materials (for example as an emulsion in an acceptable oil) or ion exchange resins, or as sparingly soluble derivatives, )' [0158] The pharmaceutical compositions also can comprise suitable solid or gel phase carriers or excipients. Examples of such carriers or excipients include but are not limited to calcium carbonate, calcium phosphate, various sugars, starches, cellulose derivatives, gelatin, and polymers such as polyethylene glycols. [0159) Pharmaceutical compositions suitable for use in the present invention include compositions wherein the active ingredients are contained in a therapeutically effective amount. The amount of composition administered will, of course, be dependent on the subject being treated, on the subject's weight, the severity of the affliction, the manner of administration and the judgment of the prescribing physician. Determination of an effective amount is well within the capability of those skilled in the art, especially in light of the detailed disclosure provided herein. [0160] For any compound used in the method of the present invention, a therapeutically effective dose can be estimated initially from celt culture assays or animal models. 0161] Moreover, toxicity and therapeutic efficacy of the compounds described herein can jc determined by standard pharmaceutical procedures in cell cultures or experimental animals, e.g., by determining the LD50, (the dose lethal to 50% of the population) and the ED so (the dose therapeutically effective in 50% of the population). The dose ratio between toxic and therapeutic effect is (he therapeutic index and can be expressed as the ratio between LDso and ED.so. Compounds which exhibit high therapeutic indices are preferred. The data obtained from these cell L uliure assays and animal studies can be used in formulating a dosage rant'e (hat is not toxic for use in human. The dosage of such compounds lies preferably v\ ithin a range of circulating concentrations that include the EDso with little or no toxicity. The' dosage can vary within this range depending upon the dosage form employed and the route of administration utilized. The exact formulation, route of administration and dosage c;sn be chosen by dhe individual physician in view of the patient's condition. (See, e.g.,F\\\f:,let al. 1975 In; The Pharmacological Basis of Therapeutics, Ch. 1). [0162] The amouin of active compound that can be combined with a carrier material to produce a single dosage form will vary depending upon the disease treated, the mammalian species, and the particular mode of administration. However, as a general guide, suitable unit doses for the compounds of the present invention can, for example, preferably contain between 100 ing to about 3000 mg of the active compound. A preferred unit dose is between 500 mg to about 1500 mg. A more preferred unit dose is between 500 to about 1000 mg. Such unit factors including the activity of the specific compound employed; the age, body weight, general health, sex and diet of the individual being treated; the time and route of administration; the rate of excretion; other drugs which have previously been administered; and the severity of the particular disease undergoing therapy, as is well understood by those of skill in the area. 10163] A typical dosage can be one 10 to about 1500 mg tablet taken once a day, or, multiple times per day, or one time-release capsule or tablet taken once a day and containing a proportionally higher content of active ingredient, The time-release effect can be obtained by capsule materials that dissolve at different pH values, by capsules that release slowly by osmotic pressure, or by any other known means of controlled release. [0164] It can be necessary to use dosages outside these ranges in some cases as will be apparent to those skilled in the an. Further, it is noted that the clinician or treating physician will know how and when to interrupt, adjust, or terminate therapy in conjunction with individual patient response Combination Therapy [0165] As noted above, tin .• (impounds of the present invention will, in some instances, be used in combination with nol. Metab. (1999) 84: 1165-71; United Kingdom Prospective Diabetes Study Group; \,].\-\ >'s 28, Diabetes Care (1998) 21: 87-92; Bardin, C, W.,(ed.), CURRENT THERAPY IN JlNuot IH .' OLOGY AND METABOLISM, 6th Edition (Mosby - Year Book, Inc., St. Louis, MO ' 1 a sson, J. et al.,Ann. Intern. Med. (1994) 121: 928-935; Coniff, R. etal., Clin. ^ «'/) 19: 16-26; Coniff, R. etal., Am. J. Med. (1995)98: 443-451; and Iwamoto, Y. et •/.,/••>/(••' e i. Med. (1996) 13 365-370; Kwiterovich, P. Am. J. Cardiol (1998) 82(12A): 3U-1 VIJ). I W'se studies indicate that diabetes and hyperlipidemia modulation can be further improved by the addition of a second agent to the therapeutic regimen. Combination therapy includes administration of a single pharmaceutical dosage formulation which contains a compound having the general structure of Formula la or Ib and one or more additional active agents, as well as administration of a compound of Formula la or Ib and each active agent in its own separate pharmaceutical dosage formulation. For example, a compound of Formula la or Ib and an HMG-CoA reductase inhibitor can be administered to the human subject togetb^jn a single oral dosage composition, such as a tablet or capsule, or each agent can be administered in separate oral dosage formulations. Where separate dosage formulations are used, a compound of Formula la or Ib and one or more additional active agents can be administered at essentially the same time (i.e., concurrently), or at separately staggered times (i.e., sequentially). Combination therapy is understood to include all these regimens. [0166} An example of combination therapy that modulates (prevents the onset of the symptoms or complications associated) atherosclerosis, wherein a compound of Formula la or Ib is administered in combination with one or more of the following active agents: an antihyperlipidemic agent; a plasma HDL-raising agent; an antihypercholesterolemic agent, such as a cholesterol biosynthesis inhibitor, e.g., an hydroxymethylglutaryl (HMG) CoA reductase inhibitor (also referred to as statins, such as lovastatin, simvastatin, pravastatin, fluvastatin, and atorvastatin), an HMG-OA synthase inhibitor, asqualene epoxidase inhibitor, or a squalene synthetase inhibitor (also known as squalene synthase inhibitor); an acyi-coenzyme A cholesterol acyitran'.-jfcrase (ACAT) inhibitor, such as melinamide; probucol; nicotinic acid and (he salts thereof and niacinamide; a cholesterol absorption inhibitor, such as /3-sitosterol; a b; le acid sequcstrant anion exchange resin, such as cholestyramine, colestipol or di alkylaminoalkyl derivatives of a cross-linked dextran; an LDL (low density lipoprotein) rervpior inducer; fibrates, such as clofibrate, bezafibrate, fenofibrate, and gemfibri ,bove, the compounds of Formula la or Ib can be administered in combination with mote than one additional active agent, for example, a combination of a compound of Formula la or Ib with an HMG-CoA reductase inhibitor (e.g., lovastatin, simvastatin and pravastatin) and aspirin, or a compound of Formula la or Ib with an HMG-CoA reductase inhi bitor and a 0 Mocker, {0167J Another example of combination therapy can be seen in treating obesity or obesity-related disorders, v. herein the compounds of Formula la or Ib can be effectively used in combination with, for exampk „ phenylpropanolamine, phentermine, diethylpropion, mazindol; fenfluramine, dexfcnfluramine, phentiramine, ft adrenoceptor agonist agents; sibutramine, gastrointestinal lipase inhibitors (such as orlistat), and leptins. Other agents used in treating obesity or obesity-related disorders wherein the compounds of Formula la or Ib can be effectively used in combination with, for example, neuropeptide Y, enterostatin, cholecytokinin, bombesin, amylin, histamine Hj receptors, dopamine D? receptors, melanocyte stimulating hormone, corticotrophin releasing factor, galanin and gamma amino butyric acid (GABA). {01681 Still another example of combination therapy can be seen in modulating diabetes (or treating diabetes and its related symptoms, complications, and disorders), wherein the compounds of Formula la or II' .an be effectively used in combination with, for example, sulfonylureas (such as chloq>iopamide, tolbutamide, acetohexamide, tolazamide, glyburide, gliclazide, glynase, glimepivide, ;mj glipizide), biguanides (such as metformin), thiazolidinediones (such as cij-lilazone, pioglitazone, troglitazone, and rosiglitazone); dehydroepiandrosterone (also referred to as DHEA or its conjugated sulphate ester, DHEA-SO-0; antiglucocorticoids; TNFa inhibitors; a-glucosidase inhibitors (such as acarbose, miglitol, and voglibose), pramlintide (a synthetic analog of the human hormone amylin), other insulin secretogogues (such as repaglinide, gliquidone, and nateglinide), insulin, as well as the active agents discussed above for treating atherosclerosis. (0169] A further example of combination therapy can be seen in modulating hyperlipidemia (treatim, hyperlipidemia and its related complications), wherein the compounds of Formula la or ib can be effectively used in combination with, for example, statins (such as flu\ astatin, lovastatin, pravastatin or simvastatin), bile acid-binding resins (such as colestipi >1 or cho'iestyramine), nicotinic acid, probucol, betacarotene, vitamin E, or vitamin C. [0170] Ad(": an antt/hyperlipidemic agent; a plasma HDL-raising agent; an antihypeicholesU'ioiemic agent, sucli as a cholesterol biosynthesis inhibitor, for example, an HMG-( 'oA reducfase inhibitor, an HMG-CoA synthase inhibitor, a squalene epoxidase inhibitor, or a squatene synthetase inhibitor (also known as squalene synthase inhibitor); an acyl-coenzyme A cholesterol acyltransfcrase inhibitor; probucol; nicotinic acid and the salts thereof; niacinanmie; a cholesterol absorption inhibitor; a bile acid sequestrant anion exchange resin; a low density lipoprotein receptor inducer; clofibrate, fenofibrate, and gemfibrozil; vitamin B& and the pharmaceutically acceptable salts thereof; vitamin 612; an anti-oxidant vitamin; a & -blocker; an angiotensin II antagonist; an angiotensin converting la or Ib and an HMG-CoA reductase inhibitor can be administered to the human subject together in a single oral dosage composition, such as a tablet or capsule, or each agent can be administered in separate oral dosage formulations. Where separate dosage formulations are used, a compound of Formula la or Ib and one or more additional active agents can be administered at essentially the same time (i.e., concurrently), or at separately staggered times (i.e., sequentially). Combination therapy is understood to include all these regimens. [0166] An example of combination therapy that modulates (prevents the onset of the symptoms or complications associated) atherosclerosis, wherein a compound of Formula la or Ib is administered in combination with one or more of the following active agents: an antihyperlipidemic agent; a plasma HD1 .-raising agent; an antihypercholesterolemic agent, such as a cholesterol biosynthesis inhibit"?, e.g., an hydroxymethylglutaryl (HMG) CoA reductase inhibitor (also referred to as statins, such as lovastatin, simvastatin, pravastatin, fluvastatin, and atorvastatin), an HMG-CoA synthase inhibitor, a squalene epoxidase inhibitor, or a squalene synthetase inhibitor (also known as squalene synthase inhibitor); an acyl-coenzyme A cholesterol nrylt.ransferase (ACAT) inhibitor, such as melinamide; probucol; nicotinic acid and theta carotene; a beta-blocker; an angiotensin II antagonist; an angiotensin converting enzyme inhibitor; and a platelet aggregation inhibitor, such as fibrinogen. receptor antagonists (i.e., glycoprotein Ilb/IIIa fibrinogen receptor antagonists) and aspi-i in. As noted above, the compounds of Formula la or Ib can be administered in comb1; nation with more than one additional active agent, for example, a combination of a com pound of Formula la or Ib \vith an HMG-CoA reductase inhibitor (e.g., lovastatin, simvastatin and pravastatin) and aspirin, or a compound of Formula la or Ib with an HMG-CoA reductase inhibitor and a (] blocker. [01671 Another example of combination therapy can be seen in treating obesity or obesity-related disorders, wherein the compounds of Formula la or Ib can be effectively used in combination with, for example, phenylpropanolamine, phentermine, diethylpropion, ma/'indol; fenfluramine, dexfenflurainine, phentiramine, ft adrenoceptor agonist agents; sibutramine, gastrointestinal lipase inhibitors (such as orlistat), and leptins. Other agents used in treating obesity or obesity-related disorders wherein the compounds of Formula la or Ib can be effectively used in combination with, for example, neuropeptide Y, enterostatin, cholecytokinin, bombesin, amylin, histamine Hb receptors, dopamine Da receptors, melanocyte stimulating hormone, corticotrophin releasing factor, galanin and gamma amino butyric acid (GABA). [01681 Still another example of combination therapy can be seen in modulating diabetes (or treating diabetes and its related symptoms, complications, and disorders), wherein the compounds of Formula la or Ib can be effectively used in combination with, for example, sulfonylureas (such as chloqiropamide, tolbutamide, acetohexamide, tolazamide, glyburide, gliclazide, glynase, glimepiride, and glipizide), biguanides (such as metformin), thiazolidinediones (such as ciglitazone, pioglitazone, troglitazone, and rosiglitazone); dehydroepiandrosterone (also referred to as DHEA or its conjugated sulphate ester, DHEA-S0 [0170] Additionally, an effective amount of a compound of Formula la or Ib and a therapeutically effective amount of one or more active agents selected from the group consisting of: an antihyperlipidemic agent; a plasma HDL-raising agent; an antihypercho'iestei ilcmic agent, -such as a cholesterol biosynthesis inhibitor, for example, an HMG-CoA reductase inliibiVi, an HMG-CoA synthase inhibitor, a squalene epoxidase inhibitor, r a squalene synth enzyme inhibitor; a platelet aggregation inhibitor; a fibrinogen receptor antagonist; aspirin; phentiramines, j3j adrenergic receptor agonists; sulfonylureas, biguanides, a-glucosidase , inhibitors, other insulin secretogogues, and insulin can be used together for the preparation of a pharmaceutical composition useful for the above-described treatments. Kits [0171] In addition, the present invention provides for kits with unit doses of the compounds of Formula la or Ib, either in oral or injectable doses. In addition to the containers containing the unit doses will be an informational package insert describing the use and attendant benefits of the drugs in alleviating symptoms and/or complications associated with Type 2 diabetes as well as in alleviating hyperlipiclemia and hyperuricemia, or for alleviating conditions dependent on PPAR. Preferred compounds and unit doses are those described herein above. [0172] For the compositions, methods and kits provided above, one of skill in the art will understand that preferred compounds for use in each are those compounds that are preferred above and particularly those compounds provided in formulae Ha through Hat, and Ilia through lilt in Figures ,', \, 4 A, 4B, 5 A, 5B and 5C. Still further preferred compounds for the compositions, method' and kits are those compounds provided in the Examples below. EXAMPLES Experimental Section {0173] General Methods. All operations involving moisture and/or oxygen sensitive materials were conducted under an atmosphere of dry nitrogen in pre-dried glassware. Unless noted otherwise, materials were obtained from commercially available sources and used without further purification 10174] Flash chromatography was performed on E. Merck silica gel 60 (240-400 mesh) according to the protocol of Still, Kahn, and Mitra (J. Org. Chem, 1978, 43, 2923). Thin layer chromatography was performed usinu precoated plates purchased from E. Merck (silica gel 60 PF254, 0.25 mm) and spots were visualized with long-wave ultraviolet light followed by an appropriate staining reagent. [0175] Nuclear magnetic resonance (NMR) spectra were recorded on a Varian Inova-400 resonance spectrometer. 'H NMR chemical shifts are given in parts per million (6) downfield from tetramethylsilane (TMS) using TMS or the residual solvent signal (CHCb = 5 7.24, DMSO = 8 2.50) as internal standard. ' 11 NMR information is tabulated in the following format: number of protons, multiplicity (s, singlet; d, doublet; t, triplet; q, quartet; m, multiplet), coupling constant(s) (/) in hertz, and, in selected cases, position assignment. The prefix app is occasionally applied, in cases where the true signal multiplicity was unresolved and br indicates the signal in )> estion was broadened. [0176] Combustion analy es were performed by Robertson Microlit Laboratories, Inc. (Madison, N.J.) and optir.,.1 rotations were measured on Perkin-Elmer 241 MC polarimeter and reported as: [ [0177] Two ro>: f are illustrated below which are useful in preparing the coumpounds disclosed in thu, .invention. In Route I, a-bromo-phenylacetate S-l was treated with a phenol, aniliii' u henzenethiol S-2 under basic condition to yield a-phenoxy-, a-phenylamiMo- or a- phenylsulfanyl-phenylacetate S-3. Hydrolysis of S-3 under basic condition yielded the corresponding acid S-4. Alternatively, S-3 was alkylated with a corresponding alkyl halide followed by basic hydrolysis to afford the alkylated acid S-5. In route B, intermediates S-7 with an electron withdrawing RI such as 4-CF3 were treated with a-hydroxy, amino, or mercapto-phenyl acetic acid S-6 under strongly basic condition to afford phenylacetic acid S-8 directly. (Figure Remove) [0178] The compc , nds listed in Tables 1 through Table 12 were either synthesized or can be synthesized by li ,e reaction routes and examples illustrated throughout the experimental section. All th-- Mitermediates and final products can be prepared by known procedures or by those skillt"i m the arts, (Table Remove) 1. Synthesis of substituted a-bromo-phenylacetates [0179] Scheme 1 illustrates the general preparative routes for the synthesis of substituted a-bromo-phenylacetates, ot-hydroxy-phenylacetic acids and a-hydroxy-phenylacetates. All of the intermediates can be prepared by known procedures or by those skilled in the arts. Scbemel. Synthesis of substituted a-bromo-phenylacetate, a-hydroxy-phenylacetic acid and ct-hydroxy-phenylacetate (Figure Remove) [0180] A 2 L three neck roundbottom flask was equipped with an efficient condenser attached to an acid scrubber, a magnetic stir bar, and was placed under nitrogen. 4-Chloiophenylacetic acid (200 g) and 1000 mL of 1,2-dichloroethane were added, followed by thi'.myl chloride (103.6 mL). The condenser was cooled with 4°C water. The mixture was I eated to an internal temperature of 55-60°C. Gas evolution was observed and the solid dissolved as the internal temperature rose to 55-60°C over 45 min. Bromine (66 mL) was added and the mixture was maintained at 55-60°C for 18 h. The internal temperature was then raised to 80-85°C over 1.5 h and heating was continued for 18h. The solution was cooled to room temperature, and 247 mL of ethanol was added slowly at 0 °C. The solution was washed with water and dried over anhydrous sodium sulfate. The solvent was removed to give 270 g of crude product compound SBr-1, which was used without further purification. 'H NMR (400 MHz, CDC13): 5 7.50-7.33 (dd, 4H), 5.29 (s, 1H), 4.24 (q, 2H), 1.28 (t, 3H). (Figure Remove) [0181] In the same manner as 'hat described in Example 1, compound SBr-2 can be prepared from commercially available SI-6. (Figure Remove) [0182] In the same manner as that desa ibed in Example 1, compound SBr-3 can be prepared from commercially available ">',l-7. (Figure Remove) [0184] To a solution of (a, a, a-trifluoro-m-tolyl)acetic acid SI-8 (202.36 g, 0.99 mol) in absolute ethanol (1.0 L) at 0 °C was added thionyl chloride (79 mL, 1.05 mol), and the resulting solution was refluxed for 3 h. Concentration in vacua gave a residue which was partitioned between EtOAc and water. The organic layer was washed with sat. NaHCCb and brine, dried over NaaSC^ and concentrated in vacua to afford 220.1 g (96%) of crude ethyl ester SI-9 as a pale yellow liquid. To a mixture of crude ethyl ester SI-9 (1 19.15 g, ca. 0.51 mol) and NBS (100.48 g, 0.56 mol) in CC14 (1.0 L) was added benzoyl peroxide (1.0 g). The resulting mixture was heated at 75 °C for 20 min. and then refluxed at 90 °C overnight (14 h) until the brown mixture became nearly colorless with white precipitate. The mixture was cooled to 0 °C, filtered through a pad of celite, and concentrated in vacua to afford 151.27 g (95%) of bromide SBr-5 as a pale brown liquid. The product was sufficiently pure to be used directly in the subsequent substitution reaction. This product was also prepared by refluxing (a, a, a-trifluoro-/M-tolyl)acetic acid SI-8 with bromine in the presence of SOCb, and then quenching with EtOH. 1H NMR (400, MHz, CDC13): 6 7.80 (1H, s), 7.77 (1H, d, J= 7.6 Hz), 7.61 (1H, d, J= 8.0 Hz), 7.51 (1H, t, J= 7.8 Hz), 5.35 (1H, s), 4.26 (2H, q), 1 .30 (3H, t). [0185] In the same manner as that - '.escribed in Example 5, compound SBr-6 was prepared from commercially available Sl-10 1HNMR (400 MHz, CDC13): 8 7.58 (m,lH), 7.42 (m, 2H), 7.30 (m, 2H), 5.29 (s, 1H), 4.26 (m, 2H), 1.30 (t, 3H). (Figure Remove) manner as that described in Example 5, compound SBr-7 was prepared from commercially available SI-12. 'HNMR (400 MHz, CDC13): 5 7.43 (d,2H), 6.88 (d,2H), 5.38 (s,lH), 3.81 (s,3H), 3.79 (s,3H). (Figure Remove) I0187| In the same manner as that described in Example 5, compound SBr-8 was prepared from commercially available SI-14. 'H NMR (400 MHz, CDC13): 6 7.62-7.35 (m, 9H), 5.41 (s,lH),3.82(s,3H). (Figure Remove) [0188] In the same manner as that described in Example 5, compound SBr-9 was prepared from commercially available SI-16. 'HNMR (400 MHz, CDC13): 6 7.28 (m,lH), 7.09 (m,lH), 6.88 (m,lH), 6.72 (m.lH), 5.33 (s.lH), 4.26 (m,2H), 3.80 (s,3H), 1.29 (t,3H). (Figure Remove) [0189] In the same manner as that described in Example 5, compound SBr-10 was prepared from commercially available SI-18. 'H NMR (400 MHz, CDC13): 5 7.40-6.98 (m, 9H), 5.30 (s,lH), 3.80 (s,3H). (Figure Remove) 10190] To a mixture of 4-(trifluoromethyl)-benzaldehyde SI-20 (25 g), a catalytic amount of KCN and 18-crown-6 in dichloromethane (150 mL) was added slowly TMSCN (21.0 mL) at 0 °C. The reaction mixture was stirred at room temperature overnight and washed with aqueous sodium bicarbonate solution. The solvent was removed under vacuum to give a crude cyano product. [0191] The above cyano product was dissolved in methanol, and HC1 gas was then bulbed through for several minutes at 0 °C. The solution was stirred overnight at room temperature, neutralized with aqueous NaOH solution, concentrated, and extracted with ethyl acetate. The organic solution was dried over anhydrous sodium sulfate and concentrated. Purification with flash column chromatography (hexanes/ethyl acetate 1/5) gave the desired hydroxyl product SI-22 (28.75 g, 86%) as a colorless oil. 'H-NMR (DMSO, 400MHz): 8 7.58 (m, 4H), 5.21 (s, lH),3.70(s,3H). (Figure Remove) [0192] To a solution of rn droxyl ester Sl-22 (28 g) in dichloromethane (250 mL) containing triphenylphosr'nmc (31.4 g) was slowly added carbon tetrabromide (40 g) at 0 °C, and then the soluti* .p ^ as stirred at room temperature overnight. The solution was concentrated and diluted with ethyl acetate/hexanes (2/3, 300 mL). A white precipitate was formed and filtered out. 1 he solvent was removed, and the residue was purified by flash column chromatography (hexane/ethyl acetate 5/1) to give the bromide product SBr-11 (35 g, 99%) as a colorless oil '! 1 NMR (DMSO, 400MHz): 6 7.78 (m, 4H), 6.10 (s, 1H), 3.68 (s, 3H). (Figure Remove) (0193] In the same manner as that described in Example 11, compound SI-25 was prepared from commercially available SI-23 as a colorless oil. 'H NMR (400 MHz, CDCh): 5 7.31 (d, 2H), 7.19 (d, 2H), 5.99 (d, 1H), 5.10 (d, 1H), 3.59 (s, 3H), 2.58 (q, 2H), 1.16 (t, 3H). (Figure Remove) [0194] In the same manner as that described in Example 12, compound SBr-12 was prepared from SI-25. 'H NMR (400 MHz, CDC13): 6 7.46 (d, 2H), 7.24 (d, 2H), 5.91 (s, IH), 3.71 (s,3H), 2.58 (q,2H), 1.16 (t, Ml). (Figure Remove) [0195] Differently subs tituted a-hydn >xy phenyl acetic acids SOH-X were purchased from a variety of commercial suppliers. The free acids can then be refluxed in absolute ethanol with 1-2 equivalent of thionyl chloride to afford esters SI-26 after evaporation of the solvent. Alternatively, SI-26 can be prepared from the corresponding aldehydes as described in Examples 11 and 13. (Figure Remove) [0196] In the same manner as that described in Example 12 and 14, compound SBr-X can be prepared from SI-26. 2. Synthesis of 2-benzooxazol-2-yl-phenols [0197] Scheme 2 illustrates the general route for preparing 2-benzooxazol-2-yl-phenols or 2-benzooxazol-2-yl- phenylfluorides. Generally, 2-fluoro or 2-hydroxyl benzoic acid was transformed to the corresponding acyl chloride. The acyl chorides were then reacted with aminophenols and were further dehydrated to afford the corresponding 2-benzooxazol-2-yl-phenols or 2-benzooxazol-2-yl-phenylfluorides. 2-benzooxazol-2-yl-phenylfluorides were converted to 2-benzooxazol-2-yl-phenols by reacting with sodium methoxide followed by demethylation. All of the intermediates can be prepared by known procedures or by those skilled in the arts. (Figure Remove) 0199] A mixture of SI-32 (19.2'1 g, 0.111 mol) and SOC12(30 mL) was refluxed for 2h. The mixture was concentrated to dryness. Rei rystallization of the residue from MeOH gave phenol PhOH-2 as an oft -white solid (20.9 g, 77%). 'HNMR (d-DMSO, 400 MHz) 5 11.22 (s, 1H), 7.98 (a, 1H), 7.85 (m, 2H), 7.53-7.45 (m, 3H), 7.16 (d, 1H). (Figure Remove) [0201] In the same manner as thai 'inscribed in Example 18 compound PhOH-3 can be prepared from commercially available Sl-33. (Figure Remove) [0202] In the same inanuci as thai described in Example 18 compound PhOH-4 can be prepared from commercially >•• ai ,able SI-34. (Figure Remove) [0203] In the same manner as that described in Example 18 compound PhOH-5 can be prepared from commercially available SI-35. (Figure Remove) |0204] In the same manner as that described in Example 18 compound PhOH-X can be prepared from commercially available SI-28. (Figure Remove) J0205] 2-Fluo i o-'5-(trifluoromethyl)benzoyl chloride SI-37 was commercially obtained from Aldridi, or prepared by reflux ing a solution of 2-fluoro-5- (trifuoronieir iylmethyl)benzoid acid SI-36 (116.71 g, 0.56 mol) and thionyl chloride (81.0 mL, 1.11 m ol) in 1,2-dichloroethane (250 ml) at 80 °C for 0.5 h. Step A. To a solution of 2-fluoro-5-(l:inuoromethyl)benzoyl chloride SI-37 (25.7 g, 0.11 mol) and 2-aminophenol (13.87 ji .'. i J mol) in CH2C12 (350 ml) at 0 °C was added Et3N (18 mL, 0.13 mol). The resulting mixture was stirred at 0 °C to rt overnight, diluted with EtOAc and washed with water. The organic layer was washed with water and brine, dried over Na2SC>4 and concentrated in vacua to afford crude SI-38 (35 g). Step B. To a suspension of unpurified SI-38 (35 g, 0.11 mol) in toluenr (500 mL) was added TsOH monohydrate (6.78 g, 0.035 mol). The resulting suspension way refluxed at 80 °C with a Dean-Stork condenser for 7 h. The reaction mixture was cooled to it, concentrated in vacua, diluted with EtOAc, washed with H:©, then washed with sat. NaHCOs and brine, dried over Na2SC>4 and concentrated in vacua to afford crude PhF-1 (31.66g, 99% over two steps) as an off-white solid. 'H NMR (400 MHz, CDC13): 8 8.56 (1H, d, J= 6.0 Hz), 7.85-7.87 (1H, m), 7.78-7.81 (1H, m), 7.64-7.67 (1H, m), 7.41-7.44 (3H, m) ppm. Step C. To a solution of unpurified PhF-1 (31.62 g, 0.11 mol) in THF (200 mL) at -5 °C was added NaOMe (8.95 g, 0.16 mol). The resulting solution was warmed up to rt, and stirred at rt for 1.5 h, quenched with sat. NH4C1, and diluted with EtOAc. The organic layer was separated and washed with HaO and sat. NHUCl, dried over Na2S04 and concentrated in vacua to afford crude SI-39 (31.89 g) as an off-white solid. This product was sufficiently pure to be used directly in the subsequent demethylation reaction, and the analytical pure SI-39 can be obtained by recrystalization from CtbCh- 'H NMR (400 MHz, CDC13): 8 8.44 (1 H, s), 7.84-7.86 (1H, m), 7.77 (1H, d, J = 8.8 Hz), 7.62-7.64 (1H, m), 7.36-7.41 (2H, m), 7.18 (1H, d, J = 8.8 Hz) ppm. Step D. A solution of unpurified SI-39 (32.89 g, 0.11 mol) in anhy. CH2C12 (500 mL) at -78 °C was treated with BBr3 (17 mL, 0.18 mol). The resultant cloudy solution was warmed to -10 °C over 2 h and stirred at rt for another 2 h. The reaction mixture was cooled to 0 °C and quenched with water. Concentration in vacua gave a residue which was partitioned between EtOAc and water. The organic layer was washed with water, sat. NaHCCh and brine, dried over Na2S04 and concentrated in vacua (Figure Remove) [0206] In the same manner as that described in Example 23 compound PhF-2 and PhOH-7 can be prepared from commercially available SI-36 and SI-29. 3. Synthesis of Compounds I and la in Table 1 J0207] One or two route s illustrated in Scheme 3 were used to prepare the compounds I and la listed in Table 1. In route A, a-bromo-phenylacetate was treated with 2-benzoxazoyl-phenol under basic condition to yi (Figure Remove) [0208] A mixture of bromo ester SBr-1 (5.0 g), phenol PhOH-1 (4.1 g), and K2CO3 (3.9 g) in DMF was stirred at room tempe rature overnight until no starting material was left as judged by TLC. The reaction mixture was diluted with water and extracted with ethyl acetate. The organic solution was dried over anhydrous Na2S04 and concentrated. The residue was purified with flash chromatography (ethyl acetate/hexanes 1:5) to give the desired ester SI-41 (4.6 g) as a colorless oil. 'H NMR (400 MHz, CDC13): 6 8.22-6.98 (m, 12H), 5.79 (s, 1H), 4.18 (q,2H), 1.17 (t,3H). [02091 The ester (1.0 g) was d> ssolved in THF (5 mL), and mixed with a LiOH solution (1.0 N, 20 mL). The mixture A is stirred at room temperature overnight and extracted with ethyl acetate. The organic soluti.on was washed with 0.1 N HC1, and dried over anhydrous Na2S04 and concentrated. Purification with flash chromatography (ethyl acetate) gave the desired acid 1-1 (0.82 g) as a white solid. 'H NMR (400 MHz, DMSO): 6 8.10-7.12 (m, 12H),5.42(s, 1H). (Figure Remove) [0210] In the same manner as that described in Example 25 compound 1-2 was prepared from SBr-10 and PhOH-1 as a white solid. 'H NMR (400 MHz, DMSO): 8 8.24-6.82 (m, 17H),5.44(s, (Figure Remove) [0211] In the same nanner as that described in Example 25 compound 1-3 was prepared from SBr-5 and PliOH-1. (Figure Remove) [0212] Step A:To a solution of phenol PhOH-6 (0.9882 g, 3.54 mmol) in DMF (10 mL) was added K2C03 (0.92 g, 6.66 mmol) followed by bromide SBr-1 (1.20 g, 4.57 mmol). After stirring for 0.5 h at rt, the re; iction mixture was diluted with EtOAc and water. The organic layer was washed with sal NaHCCh and brine, dried over Na2SC>4 and concentrated in vacua. Purification via recrystallization from CHaCh afforded ester SI-44 (1.3698 g) as a snow-white solid. 'H NMR (400 MHz, CDC13): 6 8.55 (1H, s), 7.82-7.85 (1H, m), 7.78 (2H, dd, J = 8.4, 2.0 Hz), 7.71 (IH, d, /= 8.8 Hz), 7.60-7.62 (IH, m), 7.39-7.45 (4H, m), 7.05 (IH, d, J= 8.8 Hz), 5.84 (IH, s), 4.18-4.23 (2H, m), 1.17-1.21 (3H, m). Step B. To a solution of ester SI-44 (0.9658 g, 2.03 mmol) in THF / H2O (20 mL / 5 mL) at rt was added lithium hydroxide monohydrate (0.43 g, 10.25 mmol). The resulting solution was stirred at rt for 1 h, quenched with IN aqueous HC1 and extracted with EtOAc. The organic layer was washed with brine, dried over Na2S04 and concentrated in vacuo to afford acid 1-88 (0.8842 g) as a white solid. !H NMR (400 MHz, DMSO-rfa): 6 8.41 (IH, d, J= 2.0 Hz), 7.99 (IH, dd, J = 9.2, 2.0 Hz), 7.89 (IH, dd, J = 6.8, 2.0 Hz), 7.83-7.86 (IH, m), 7.83 (2H, d, /= 8.6 Hz), 7.59 (2H, d, J = 8.6 Hz), 7.43-7.50 (2H, m), 7.40 (IH, d, J= 8.8 Hz), 6.34 (IH, s). (Figure Remove) [0213] In the same manner .as that described in Example 28 compound 1-89 was prepared from SBr-5 and PhOH-6 as a white solid. 'H NMR (400 MHz, DMSO-^): 8 8.40 (IH, d, /= 2.0 Hz), 8.35 (IH, s), 8.04 (IH, d,J= 7.6 Hz), 7.97 (IH, dd, 7- 8.8, 2.4 Hz), 7.82 (IH, dd, J = 6.8, 2.4 Hz), 7.75-7.77 (IH, m), 7.74 (IH, d, J= 4.4 Hz), 7.69 (2H, t,/= 7.8 Hz), 7.43-7.50 (2H, m), 7.39 (IH, d, J- 9.2 Hz), 6.27 (IH, s) ppm. (Figure Remove) [0214] In the same manner as that described in Example 28 compound 1-90 was prepared from SBr-8 and PhOH-6. *H NMR (400 MHz, DMSO): 5 8.40-6.40 (m, 16H), 5.42 (s, IH). (Figure Remove) [0215] In the same manner as that described in Example 28 compound 1-91 was prepared from SBr-11 and PhOH-6. 'H NMR (400 MHz, DMSO): 5 8.42-7.40 (m, 11H), 6.47 (s, 1H). (Figure Remove) [0216] In the same manner as that described in Example 28 compound 1-92 was prepared from SBM and PhOH-0. 'H NMR (400 MHz, DMSO-rf*): 6 8.39 (1H, s), 7.99 (1H, d, J= 8.8 Hz), 7.86 (1H, d, J 7.2 Hz), 7.77-7.79 (3H, m), 7.40-7.49 (6H, m), 6.27 (1H, s) ppm. (Figure Remove) [0217] In the same manner as that described in Example 28 compound 1-93 was prepared from SBr-7 and PhOH-6 as a white solid. 'HNMR (d-DMSO, 400 MHz) 8 13.42 (br, 1H), 8.41 (s, 1H), 8.00 (d, 1H), 7.82 (dd, 2H), 7.70 (d, 2H), 7.42 (m, 3H), 7.05 (d, 2H), 6.22 (s, 1H), 3.79 (s, 3H). (Figure Remove) [0218j In the same manner as that described in Example 28 compound 1-94 was prepared from SBr-6 and PhOH-6 as a white solid. 'HNMR (d-DMSO, 400 MHz) 5 13.68 (br, 1H), 8.43 (d, 1H), 8.11 (s, 1H), 8.21 (dd, 1H), 7.89 (m, 1H), 7.83 (m, 1H), 7.70 (d, 1H), 7.50 (m, 4H),7.42(d, 1H), 6.40(s,l H). (Figure Remove) |0219] To a solution o f 3-(trifluoromethyl)mandelic acid SOH-1 (4.8251 g, 0.022 mol) in THF (50 mL) at 0 °C was added NaH (Aldrich, 60%, 4.928 g, 0.055 mol). After stirring for 0.5 h, fluoride PhF-1 ( (Figure Remove) [0220] To a solution of PhF-1 (1.49 g, 5.32 mmol) and SOH-2 (1 g, 5.32 rnmol) in DMF (20 mL) was added NaH (60%, 0.43 g, 10.64 mmol) in one portion at - 10 °C, and the reaction mixture was slowly warmed to room temperature over 0.5 h. After stirring at room temperature for additional 2 h, the mixture was poured into a mixture of ice and 1 N HC1 solution, filtered, washed with water and dried. Recrystallization from MeOH gave 1-95 as a white solid (1.94 g). 'HNMR (d-DMSO, 400 MHz) 6 8.42 (d, 1H), 7.99 (m, 2H), 7.85 (m, 1H), 7.79 (d, 1H), 7.58 (m, 2H), 7.49 (m, 2H), 7.44 (d, 1H), 6.38 (s, 1H). (Figure Remove) [0221) In the same manner as that described in Example 28 compound 1-190 was prepared from SBr-1 and PhOH-2 as a white solid. 'HNMR (d-DMSO, 400 MHz) 5 13.6 (br, 1H), 8.10 (d, 1H), 7.84 (m, 4H), 7.66 (dd, 1H), 7.57 (m, 2H), 7.45 (m, 2H), 7.24 (d, 1H), 6.20 (s, 1H). (Figure Remove) [0222] In the same manner as that described in Example 28 compound 1-191 was prepared from SBr-5 and PhOH-2 as a white solid. 'HNMR (d-DMSO, 400 MHz) 6 13.70 (br, 1H), 8.34 (s, 1H), 8.15 (d, 1H), 8.02 (d, 1H), 7.85-7.71 (m, 5H), 7.50 (m, 2H), 7.29 (d, 1H), 6.40 (s, 1H). (Figure Remove) [0223] In the same manner as that described in Example 28 compound 1-192 was prepared from SBr-4 and PhOH-2 as a white solid. 'HNMR (d-DMSO, 400 MHz) 8 13.45 (br, IH), 8.10 (d, IH), 7.85 (dd, IH), 7.75 (m, 3H), 7.67 (dd, IH), 7.47 (m, 4H), 7.40 (m, IH), 7.24 (d, lH),6.13(s, IH). (Figure Remove) [0224] In the same manner as that described in Example 28 compound 1-193 was prepared from SBr-7 and PhOH-2 as a white solid. 'HNMR (d-DMSO, 400 MHz) 8 13.30 (br, IH), 8.09 (d, IH), 7.82 (m, 2} 1), 7.65 (d, 3H), 7.45 (m, 2H), 7.22 (d, IH), 7.01 (d, 2H), 6.60 (s, IH). (Figure Remove) [0225] In the same manner as that described in Example 28 compound 1-194 was prepared from SBr-6 and PhOH-2 as a white solid. 'HNMR (d-DMSO, 400 MHz) 6 13.60 (br, IH), 5.13 (d, 1H), 8.07 (s, 1H), 7.87 (m, 1H), 7.80 (m, 1H), 7.68 (m, 2H), 7.48 (m, 4H), 7.23 (d, lH),6.24(s, 1H). (Figure Remove) [0226) To a suspension of NaH (0.44 g) in DMF was added dropwise a solution of ester SI-41(3.0 g) in DMF at 0 °C. The reaction mixture was stirred at the same temperature for 30 min, then Mel (0.6 ml,-) was introduced via syringe. The solution was stirred for one hour, quenched with water, extracted \vith ethyl acetate. Purification with column chromatography (hexanes/ethyl acetate '>: 1) gave the methylated ester (2.1 g). |02271 The above estei was dissolved in THF (5 mL), and mixed with a LiOH solution (1.0 N, 20 mL). The mixtuie wa? stirred at room temperature overnight, and extracted with ethyl acetate. The organic so lution was washed with 0.5 N HC1, dried over anhydrous Na2SO4, and concentrated. Purifieri"u with flash chromatography (ethyl acetate) gave the desired acid Ia-1 (1.6 g, 80%) as a white solid. 1H NMR (400 MHz, DMSO): 8 7.70-6.61 (m, 12H), 3.30 (s, 3H). [0228] In the same manner as that described in Example 42 compound Ia-93 was prepared from Sl-48. !H NMR (d-DMSO, 400 MHz) 8 1.3.85 (br, 1H), 8.38 (d, 1H), 7.90-7.87 (m, 2H), 7.83-7.79 (m, 3H), 7.52-7.42 (m, 4H), 7.36 (m, 1H), 7.07 (d, IH), 2.0 (s, 3H). . (Figure Remove) |0229] In the same manner as that described in Example 42 the rest of la-X listed in Table 1 can be prepared from Si-X. 4. Enantioselective synthesis and enantiomer separation |02301 One or more routes illustrated in Scheme 4 was or can be used to prepare the individual enanliomers of compound 1-X and la-X listed in Table 1. In route A, an enantiomerically pure rx-hydroxy-phenyl acetic acid was treated with flouro compounds PhF-X with an electron withdrawing group such as CFs under strongly basic condition to afford enantiomerically emit, lied compounds. In route B, racemic compounds were resolved into single enantiomers by seperation on a chiral HPLC. In route C, racemic compounds were resolved into single enantiomers by recrystalization with a chiral amine. (Figure Remove) 10231] To a solution ofPhF-1 (5.26 g, 0.0187 mol) and SOH-11 (3.132 g, 0.0206 mol) in DMI- (100 ml,) was added NaH (60%, 1.484 g, 0.0371 mol) in one portion at - 78 °C, and the reaction j u- lure wa1; .lowly warmed to room temperature over 1 h. After stirring at room temperatui (Figure Remove) [0232] In the same manner as that described in Example 45 compound 1-370 was prepared From PhF-1 and SOH-13. 'HNMR (d-DMSO, 400 MHz) 8 13.48 (br, 1H), 8.41 (d, 1H), 8.0 (dd, 1H), 7.86 (dd, 1H), 7.78 (m, 311), 7.46 (m, 6H), 6.29 (s, 1H). (Figure Remove) [0233] In the same manner as thai described in Example 45 compound 1-371 was prepared from PhF-1 and SOH-12. 'HNMR (d-DMSO, 400 MHz) 8 13.68 (br, 1H), 8.43 (d, 1H), 8.11 (s, 1H), 8.2! i id, 1H), 7.89 (m, IHj, 7.83 (m, 1H), 7.70 (d, 1H), 7.50 (m, 4H), 7.42 (d, 1H), 6.40 (s, 111). I-367ee%>20%. (Figure Remove) (0234] To a solution of 3-trifluoromethylmandelic acid SOH-14 (0.729 g, 3.31 mmol) in THF (20 mL) at -78 °C was added NaH (Aldrich, 60%, 0.594 g, 6.60 mmol). After warming up to -45 °C for 0.5 h, fluoride PhF-1 (0,9765 g, 3.47 mmol) was added, and then warmed up to 0 °C overnight. The reaction was checked by chiral HPLC to find that two enantiomers were produced ((+)/(-)-isomer=6:4) with 80% conversion. (Figure Remove) [0235| The two enantiomers were seperated by chiral HPLC using a 25 cm x 21.1 mm Regis Technologies (R,R) WHFLK-O 2 10/100 column at ambient temperature. Injected samples were 3.0ml. of 15.5 mg/mL solutions of the racemic 1-89 in /PrOH /hexanes (1:1, v/v). The column was eluted with (15/85/0.1) /PrOH/hexanes/TFA at a flow rate of 30 mL/min, Detection was at 220 nm. The (+)-enantiomer 1-365 eluted at 6 to 9 min, and the (-)-enantiomer 1-366 al '•' ' u> 12 min. (Figure Remove) [0236J I h e two enantiomers were seperated by chiral HPLC using a 25 cm x 21.1 mm Regis Technologies (R,R) WHELK O 2 10/100 column at ambient temperature. Injected samples were 5.0 mL of 7 mg/mL solutions of the racemic 1-92 in /PrOH / hexanes (6:4, v/v). The column was eluted with (25/75/0.1) /PrOH/hexanes/TFA at a flow rate of 30 mL/min. Detection was at 220 nrn. The (,'>)-(+)-enantiomer 1-369 eluted at 5 to 7 min, and the (/?)-(-)-enantiomer 1-370 at 8 to 10 min. (Figure Remove) [0237] The two enantiomers were seperated by chiral HPLC using a 25 cm x 21.1 mm Regis Technologies (R,R) WHELK-O 2 10/100 column at ambient temperature. Injected samples were 5.0 mL of 7 mg/mL solutions of the racemic 1-88 in j'PrOH / hexanes (6:4, v/v). The column was eluted with (25/75'0.1) /PrOH/hexanes/TFA at a flow rate of 30 mL/min. Detection was at 220 nm. The (+)- enantiomer 1-372 eluted at 6 to 8 min, and the (-)-enantiomer 1-373 at 9 to 11 min. (Figure Remove) [0238] Racemic 1-94 was resolved by chiral HPLC to give (+)-I-94 and (-)-I-94. HPLC methods and conditions, including eluents used, solvent flow rate and detection wavelength were: 20% iPrOH-80%, Hexanes-0.1% TFA, 30 mL/min., X=220 nm. For (+)-I-94: RT 5.5 min. For (-)-I-94: RT 9.5 min. (Figure Remove) [0239] Racemic 1-93 was resolved by chiral HPLC to give (+)-isomer and (-)-isomer. HPLC methods and conditions, including eluents used, solvent flow rate and detection wavelength were: 50% iPrOH-50% Hexanes-0.1% TFA, 30 mL/min., X=220 nm. For (+)-isomer: RT 4.7 min. For (-)-isomer: RT 8.75 min. (Figure Remove) [0240] The two enauliomers were seperated by chiral HPLC using a 25 cm x 21.1 mm Regis Technologies (R,R) WHELK-0 2 10/100 column at ambient temperature. Injected samples were 5.0 mL ofl2 mg/mL solutions of the racemic 1-191 in j'PrOH / hexanes (4:6, v/v). The column was eluted with (15/85/0.1) /PrOH/hexanes/TFA at a flow rate of 30 mL/min. Detection was at 220 nm. The (+)-enantiomer 1-367 eluted at 4 to 6 min, and the (-)-enantiomcr 1-368 at 7 to 9 min. (Figure Remove) [0241 ] Uacemic 1-194 was resolved by chiral HPLC to give 1-374 and 1-375. HPLC method^ and conditions, including eluents used, solvent flow rate and detection wavelength were. 35% iPrOH-65% Hexanes-0.1% TFA, 30 mL/min., X=220 nm. For 1-374: RT 4.7 min. For 1-375: RT 6.7 min. (Figure Remove) [0242] Racemic M92 was resolved by chiral HPLC to give 1-377 and 1-378. HPLC methods and conditions, including eluents used, solvent flow rate and detection wavelength were: 50% iPrOH-50% l-Icxanes-0.1% TFA, 30 mL/min., X=220 nm. For 1-377: RT 5.4 min. For 1-378: RT 7.8 min. (Figure Remove) [0243] Racemic 1-193 was i .'solved by chiral HPLC to give (+)-I-193 and (-)-I-193. HPLC methods and conditions, including eluents used, solvent flow rate and detection wavelength were: 50% iPrOH-50"-, i [ ,xanes-0.1% TFA, 30 mL/min., X=220 nm. For (+)-l-193: RT 5.5 min. For(-)-M93:R'l ,1.5 min. (Figure Remove) J0244) Racemic 1-197 was resolved by chiral HPLC to give (+)-isomer and (-)-isomer. HPLC methods and conditions, including eluents used, solvent flow rate and detection wavelength were: 40% iPrOH-60% Hexanes-0.1% TFA, 30 mL/min., X=220 nm. For (+)-isomer: RT 4.2 min. For (-)-isomer: RT 7.5 min. (Figure Remove) [0245] A suspension of I-!! 91 (37.44 g, 0.084 mol) in 750 mL of EtOH 3A was heated to reflux at 90 °C (water-bath temperature) to give a cloudy solution, then cooled to ca. 80 °C. Quinine (25.34 g, 0.07K mol) was added, and the resulting clear solution was stirred at 70-80 °C. (internal solution temperature) and solid began to crash out of the hot solution. After stirring for 1 h at 70-80 °C, and then cooled to 50°C with stirring. The solid was collected by filtration and rinsed twice with EtOH 3A. The dried solid (ca. 33 g) had an 90-93% enantiomeric excess (ee) of the (+) enantiomer, and the mother liquor had an 85-90% enantiomeru excess (ee) of the (--) enantiomer. When this hot mother liquor was cooled to rt, a second crop >olid (17.0g) was obtained. This solid had a 99% ee of the (-)-enatiomer. Chiral HPLC analysis was carried out at X = 220 nrn by injecting 10 jaL of an approximately a 0.5 mg/mL solution of the sample dissolved in mobile phase onto a 25 cm x 4.6 mm Regis Technologies (R,R) Whelk-O 1 5 u.nn column with a 1.5 mL/min flow of (25/75/0.1) /PrOH/hexaur s/TFA. Under these conditions, (+) enantiomer 1-367 eluted at 4.3 min, and (-) enantiomci at 5.8 min (approximate retention times). To the crude (+) salt (33 g) obtained above was added 520 mL of EtOH 3A, and the suspension was refluxed at 106 °C (oil-bath temperature) for 3 h, cooled to rt, filtered and rinsed twice with EtOH 3A. The white solid was dried to afford 28.32 g of the desired (+) enantiomer salt with an ee of 97-99%. To a suspension of the resolved salt (28 g) in 350 mL of EtOAc was added 45 mL of 2N HzSO^ After stirring for 10 min at rt, the resulting mixture was diluted with water (100 mL). The organic layer was separated and washed with water twice and then brine and dried over N32S04. After removal of solvents in vacua and dried at 40-45 °C / 3 mmHg, 16,26 g of desired (+) enantiomer 1-367 was obtained. Similarly, (+) enantiomer 1-367 was also obtained by resolution of racemic 1-191 using cinchonidine (0.9 eq.) in EtOH 3 A with 60% recovery of (+) enantiomer with a 97-99% ee. (Figure Remove) [0246] (+) enantiomer 1-365 and (-) enantiomer 1-366 were obtained by resolution of racemic 1-89 using jY-methyl-D-glucamine (0.9 eq.) in EtOH 3A by a similar procedure as Example 59 above. Chiral HPLC analysis was carried out at X = 220 nm by injecting 10 |iL of a 0.5 mg/mL solution of the sample dissolved in mobile phase onto a 25 cm x 4.6 mm Regis Technologies (R,R) Whelk-O 1 5 ^im column with a 1.5 mL/min flow of (15/85/0.1) /PrOH/hexanes/TFA. Under these conditions, (+) enantiomer 1-377 eluted at 4.5 min, and (-) enantiomer at 5.9 min (approximate retention times). (Figure Remove) |0247| To a solution of SOH-15 (0.62 g, 3.73 mmol) in THF (10 mL) was added NaHMDS (1.0 M in THF, 7.83 ml.) at - 10 °C and the reaction was warmed to room temperature. After stirring at room temperature for 10 min., a solution of PhF-1 (1.05 g, 3.73 mmol) in THF (10 mL) was added. The reaction mixture was heated at 60°C for 1 h, and then stirred overnight at room temperature. The reaction was quenched with 1 N HC1 solution, extracted with EtOAc, washed with brine, dried and concentrated. The residue was purified by flash column (hexane/EtOAc 10:1) to give compound Ia-365 as a white solid (0.72 g, 45%). 'HNMR (d-DMSO, 400 MHz) 5 8.38 (d, 1H), 7.89 (m, 2H), 7.81 (m, 3H), 7.48 (m, 4H), 7.36 (m, 1H), 7.07 (d, lH),2.0(s,3H). (Figure Remove) [0248J Ia-366 was obtained as a white solid from PhF-1 and SOH-16 in the same manner as that described in Example 61. 'HNMR (d-DMSO, 400 MHz) 6 8.38 (d, 1H), 7.89 (m, 2H), 7.81 (m, 3H), 7.48 (m, 4H), 7.36 (m, 1H), 7.07 (d, 1H), 2.0 (s, 3H). (Figure Remove) (Table Remove) 5. Synthesis of 2-benzothiazol-2-yl-phenols [0249] The 2-benzothiazol-2-yl-phenol or 2-benzothiazol-2-yl-phenylfluorides used for the preparation of compounds II-X and Ha-X were prepared in the same manner as that described for the synthesis of 2-benzooxazol-2-yl-phenols and 2-benzooxazol-2-yl-phenylfluorides illustrated in Scheme II or can be prepared by those skilled in the arts. (Figure Remove) [0250] Compound HiOH-11 was purchased from Aldrich Chemicals Inc., USA. (Figure Remove) [0251] A mixture of SI-32 (67 g, 0.388 mol) and SOC12 (42 mL, 0.582) was refluxed for 2h. The mixture was concentrated to dryness and put on high vaccum for a while. To the residue was added THF (700 mL) and then 2-aminothiophenol (53.4 g, 0.427 mol) was added slowly at 0 °C. To the resulted solution was added dropwise Et3N (82 mL, 0.582 mol) at 0 °C, then warmed to room temperature and stirred overnight. The reaction mixture was acidified by addding 2N HC1 and concentrated, to the residue was added water, filtered and washed with water to give a solid (98 g), which was used for the next reaction without further purification, (0252) A mixture of the above crude product (98 g) and TsOH H2O (12.5 g) in toluene (500 mL) was refluxed for 4 hours using Dean-Stark apparatus. The reaction mixture was cooled to room temperature. Filtration and washing with MeOH gave phenol PhOH-12 as an off-white solid (90 g, 89%). 1HNMR (d-DMSO, 400 MHz) 8 11.69 (s, 1H), 8.20 (d, 1H), 8.08 (d, 1H), 8.04 (d, 1H), 7.53-7.39 (m, 3H), 7.08 (d, 1H). (Figure Remove) in Example 64 compound PhOH-X can be prepared from commercially available SI-28.(Figure Remove) [0254] In the same manner as that described in Example 23 compound PhF-4 and PhOH-16 were prepared from commercially available SI-36 and 2-aminothiophenol. (Figure Remove) [0255] In the same manner as that described in Example 23 compound PhF-5 and PhOH-17 can be prepared from commercially available SI-36 and SII-1. 6. Synthesis of Compounds II and Ila in Table 2 [0256] Compounds II and Ha were or can be prepared in the same manner as that described for the synthesis of compounds I and la. (Figure Remove) [0257] In the same manner as that described in Example 28 compound II-l was prepared from SBr-6 and PhOH-11. 'HNMR (d-DMSO, 400 MHz) 8 8.44 (d, IH), 8.17 (s, IH), 8.07 (m, 3H), 7.83 (m, IH), 7.75 (m, IH), 7.55 (m, 2H), 7.47 (m, IH), 7.31 (m, IH), 7.22 (m.lH), 6.51 (s, IH). (Figure Remove) [0258] In the same manner as that described in Example 28 compound II-4 was prepared as a white solid (1.18 g). 'HNMR (d-DMSO, 400 MHz) 8 8.43 (ds, IH), 8.07 (m, 2H), 7.79 (m, IH), 7.67 (m, IH), 7.54-7.41 (in, 5H), 7.26 (d, IH), 7.19 (m, IH), 6.35 (s, IH). (Figure Remove) [0259] In the same manner as that described in Example 28 compound 11-97 was prepared from SBr-1 and PhOH-12.11-97: 'HNMR(d-DMSO, 400 MHz) 6 13.62 (br, IH), 8.40 (d, IH), 8.10 (del, 2H), 7.72 (d, 2H), 7.60-7.53 (m, 5H), 7.45 (m, IH), 7.31 (d, IH), 6.38 (s, IH). (Figure Remove) [0260] In the same manner as that described in Example 28 compound II-98 was prepared from SBr-5 and PbOH-12. 'HNMR (400MHz, DMSO-d6i):6 8.38 (d, IH), 8.11-8.00 (m, 4H), 7.83 (d, IH), 7.73 (m, IH), 7.63 (dd, IH), 7.58 (m, IH), 7.68 (m, IH), 7.34 (d, IH), 6.52 (s, IH). (Figure Remove) [0261J In the same manner as that described in Example 28 the rest of compound H-X can be prepared from SBr-X and PhOH-X. (Figure Remove) [0262] In the same manner as that described in Example 35 compound H-26 was prepared from SOH-3 and PhF-4. H-26: 'HNMR (d-DMSO, 400 MHz) 8 13.60 (br, IH), 8.71 (s, IH), 8.12 (m, 2H), 7.90 (m, IH), 7.71 (in, 2H), 7.54 (m, IH), 7.46 (m, 5H), 6.44 (s, IH). (Figure Remove) [0263] In the same manner as that described in Example 42 compound IIa-1 to IIa-157 can be prepared from SI-55. 7. EnantiosdecLive synthesis and enantiomer separation [0264] The enantiomers of compounds II-X and Ha-X were or can be obtained in the same manner as that decribed in Section 4 and Example 45 to Example 62. (Figure Remove) [0265] (+)-Jl-22 and (-)-II-22 was separated in the same manner as described in Example 49. [0266] (+)-II-98 and (-)-II-98 was separated in the same manner as described in Example 49 (Figure Remove) [0267] In the same manner as that described in Example 18 compound PhOH-18a, 19a can be prepared from commercially available SI-29 and SIII-1. (Figure Remove) [0268] In the same manner as that described in Example 28 compound III-X can be prepared from commercially available SBr-X and PhOH-18a, 19a. (Table Remove) (Figure Remove) [0269] In the same manner as that described in Example 18, PhOH-18 can be prepared from SIV-1. (Figure Remove) [0270] In the same manner as that described in Example 18, PhOH-19 was prepared from SIV-2. PhCMM9: 'H NMR(CDC13, 400 MHz) 8 7.82 (m, 1H),7.71 (d, 1H),7.61 (m, 1H), 7.39 (m, 2H), 7.23 (m, 1H), 6.98 (d, 1H), 5.40 (br, 1H), 2.69 (s, 3H). (Figure Remove) [0271] In the same manner as that described in Example 28 compound IV-11 was prepared from SBr-2 and PhOH-19 (Figure Remove) |0272] In the same manner as that described in Example 28 compound IV-12 was prepared from SBr-l and PhOH-19. IV-11: 'llNMR(d-DMSO, 400 MHz) 8 13.41 (br, 1H), 7.83 (d, 1H), 7.80 (d, 1H), 7.65 (m, 3H), "> .52 (d, 2H), 7.46-7.39 (m, 2H), 7.35 (m, 1H), 7.16 (d, 1H), 6.05 (s, !H),2.69(s,3H). (Figure Remove) (0273J h i the same manner as that described in Example 28 the rest of IV-X listed Table 4 can be prepared. (Table Remove) [0277] The 2-benzooxazole and 2-benzothiazole anilines used for the preparation of (Figure Remove) [0279], In the similar manner as that described in Example 18, PhNHa-X can be prepared from SVI-3. 9. Synthesis of Compounds VI and Via in Table 6 |0280] Compounds VI-X and Vla-X were or can be prepared in the same manner as that described for the synthesis of compounds I-X and la-X. [0281 ] In the same manner as that described in Example 28 compound VI-28 was prepared from SBr-1 andPhNH2-l. (Figure Remove) (0282] In the same manner as that described in Example 28 the rest of compounds VI-X in Table 6 can be prepared from SBr-X and PhNH2-X. (Figure Remove) |0283] A mixture of PhF-1 (j .124 g, 4,0 mmol), SVI-4 (0.914 g, 4.40 mmol) and iPr2NEt (1.32 mL, 7.6 mmol) in DMF (10 mL) was heated at 100 °C for 24 h. After cooling to room temperature the mixture was poured into a mixture of ice and waterand extracted with EtOAc. The organic las/er was washed with brine, dried and concentrated. The residue was recrystallized from MeOH to give a white solid (0.6g). [0284] To the above product in THF/MeOH (15 mL/30mL) was added 1M LiOH solution (10 mL). The mixture was heated at 70 °C for 0.5 h, cooled to room temperature and quenched by adding 1 N HC1 (10 mL). The mixture was concentrated and extracted with EtOAc. The organic layer washed with water, dried and concentrated. Crystallization from MeOH gave VI-63 as a white solid (0.45 g). 'H NMR (d-DMSO, 400 MHz) 8 9.87 (d, 1H), 8.28 (d, 1H), 7.85 (m, 2H), 7.60 (dd, 1H), 7.50 (m, 7H), 6.83 (d, 1H), 5.61 (d, 1H). (Figure Remove) [0285] In the same manner as that described in Example 91 compound VI-70 to VI-80 and VI-90 to VI-100 in Table 6 can be prepared from SVI-5 and PhF-1. 10. Enantioseiective synthesis and enantiomers separations [0286] The individual enantiomers of compounds VI-X and Vla-X listed in Table 6 can be obtained in the same manner as that described in Section 4 and Example 45 to Example 62. (Table Remove) 11. Synthesis of2-Benzoimidazol-2-yl-phenol [0288] Scheme 6 illustrates the general route for preparing 2-benzoimidazol-2-yl-phenols. Generally, hydroxyl benzoic acids were treated with o-phenylenediamines under strongly dehydration conditions to afford the corresponding benzoimidazol-2-yl-pheno!s. (Figure Remove) manner as that described for the synthesis of PhOH-21 in Example 93. (Figure Remove) [0291 j PhOH-23 was prepared according to the literature procedure [Indian J. Chem., Sect. B. 198(11), 967-9; 1980] (Figure Remove) [0292] Compounds VIII-X can be prepared with SBr-X and PhOH-21, 22, and 23 in the same manner as that described in Example 28. (Table Remove) (Figure Remove) [0294] In the same manner as that described in Example 28 compound IX-23 was prepared from SBr-1 and PbOH-26. 'liNMR (400 MHz, d-DMSOd6): 5 8.76 (d, 1H), 7.87 (d, 1H), 7.59 (s.lH), 7.66 IM, 4HI), 7.36'(s,lH), 7.17 (d.lH), 6.27) (s, 1H). (Figure Remove) [0295J In the same manner as that described in Example 28 compound IX-20 was prepared from SBr-5 and PhOH-26. IX-20: 1E NMR (d-DMSO, 400 MHz) 5 13.69 (br, IH), 8.76 (d, IH), 7.87 (d, IH), 7.59 (s, IH), 7.48-7.43 (rn, 4H), 7.36 (s, IH), 7.16 (d, IH), 6.27 (s, IH). (Figure Remove) [0296] In the same manner as that d ,;vd in Example 28 compound IX-23 was prepared from SBr-l and PhOH-26. 'H NMR (dDMSO, 400 MHz) 5 (8.74 (d, IH), 7.87 (d, IH), 7.52 (m, 2H), 7.45 (m, 3H), 7.33 (d, 1 Hi, 7.14 (d, IH), 6.27 (s, IH). (Figure Remove) [0297] In (he same manner as that described in Example 28, the rest of compounds IX-X can be prepared. (Figure Remove) [0298] In the same manner as that described in Example 42 compound IXa-X can be prepared from SIX-1. (Figure Remove) [0299] Raccn IX -23 was resolved by chiral HPLC to give (+)-IX-23 and (-)-IX-23. HPLC method: ' > d • onditions, including eluents used, solvent flow rate and detection wavelength were: 2-)% iPrOH-80% Hexanes-0.1% TFA, 30 mL/min., X=220 nm. For (+)-IX-23: RT 6 ^ ,nin. 'or (-)-IX-23: RT 7.0 min. (Figure Remove) [0300] Racemic IX-20 was resolved by chiral HPLC to give (+)-IX-20 and (-)-IX-20. HPLC methods and conditions, including eluents used, solvent flow rate and detection wavelength were: 20% iPrOH-80% Hexanes-0.1% TFA, 30 mL/min., X=220 nm. For (+)-IX-20: RT 6.6 min. For (-)-IX-20: RT 6.9 min. (Table Remove) (Figure Remove) [0306] Nitro aniline (138.13 g) was mixed with 500 mL of concentrated HCI and stirred for several min. When all the aniline was dissolved, the solution was cooled down to room temperature and diluted with water (300 mL), and then a solution of NaNC>2 (69 g) in 250 mL of water was dropwise added at 0 °C. The solution became a clear and yellowish solution. The diazonium salt solution was added slowly to a solution of phenol (128.5 g) in water (SOOmL) containing 80 g of NaOH at 0 °C. When the addition was complete, the reaction mixture was stand for several hours, a black precipitate was formed and filtered. The solid was dissolved in ethyl acetate, washed with brine, dried over anhydrous NaaSO,*. The solution was concentrated to give 133.5 g of nitroazophenol product as light yellow solid. ^he mother liquor was concentrated again to give another 65 g of the nitroazophenol product. H-NMR (400 MHz, CDC13): 5 10.98 (s, 1H), 8.20 - 7.05 (m, 7H). 03071 A mixture of nitroazophenol (40 g), thiourea dioxide (30 g), 500 mL of NaOH iolution (4 N) and 500 mL ethanol was stirred for half an hour at 80 °C, and then 15 g of hiourea dioxide was added. The solution was stirred for another one hour, diluted with ice-water, extracted with ethyl acetate, dried over anhydrous Na2SC>4. The solution was concentrated to give 21 g of PhOH-45 i; > a white solid. 'H-NMR (400 MHz, CDC13): 8 1 1.25 (s, 1H), 8.40- 7.15 (m,7H). (Figure Remove) J0308] In the ,ame manner as that described in Example 107, PhOH-46 was prepared from phenol -XI-3. 'H-NMR (400 MHz, CDC13): 6 11.78 (s, 1H), 8.71 - 7.23 (m, 7H). (Figure Remove) [0309] PhOH-47 can be prepared from SXI-1 and SXI-4 in the same manner as that described in Example 107. 15. Synthesis of Compounds XI and XIa in Table 11 [0310] Compounds XI and XIa were or can be prepared in the same manner as that described for the synthesis of compounds I-X and la-X. (Figure Remove) [03111 XI-1 was prepared from SBr-6 and PhOH-40 in the same manner as that described in Example 28. 'H-NMR (d-DMSO, 400 MHz) 5 8.15 (m, 2H), 7.63 (d, IH), 7.57 (m, 3H), 7.40 (m, 4H), 7.20 (d, IH), 6.15 (s, IH), 2.38 (s, 3H). (Figure Remove) [0312| XI-2 was prepared from SBr-5 and PhOH-40 in the same manner as that described in Example 28. 'H NMR (400 MHz, DMSO-rf*): 6 7.98 (2H, dd, J= 6.6, 3.2 Hz), 7.72 (2H, d, 7= 6.0 H?.), 7.66 (IH, d, J = 8.4 Hz), 7.60 (IH, d, /= 2.4 Hz), 7.57 (IH, d, J= 7.6 Hz), 7.51 (2H, dd, J- 6.6, 3.2 Hz), 7.39 (IH, dd, J = 8.8, 2.0 Hz), 7.19 (IH, d, J= 8.8 Hz), 616 (lH,s),2.40(3H,s). (Figure Remove) [0313] XI-5 was prepared from SBr-1 and PhOH-40 in the same manner as that described in Example 28. 1H NMR (400 MHz, DMSO-d«(): 6 8.02 (2H, dd, J= 6.8, 3.2 Hz), 7.56 (1H, dd, J- 3.2, 0.8 Hz), 7.50 (2H, dd,./ - 6.8, 3.2 Hz), 7.41-7.44 (2H, m), 7.34-7.37 (3H, m), 7.14 (1H, d, J = 8.8 Hz), 5.92 (1H, s), 2.32 (3H, s). (Figure Remove) [0314] XI-6 was prepared from SBr-11 and PhOH-40 in the same manner as that described in Iixamp (Figure Remove) [0315] XJ-8 was prepared from SBr-4 and PhOH-40 in the same manner as that described in Example 28. 'HNMR (CDC13, 400 MHz) 5 7.96 (m, 3H), 7.54-7.46 (m, 7H), 7.12 (d, 1H), 6.96 (d, 1H), 5.84 (s, 1H), 2.35 (s, 3H). (Figure Remove) [0316] XI-14 was prepared from SBr-1 and PhOH-41 in the same manner as that described in Example 28. 'HNMR (400 MHz, DMSO): 6 8.10-7.15 (m, 11H), 6.0 (s, 1H), 1.70 (s, 2H), 1.32 (s. 6H), 0.68 (s, 9H). (Figure Remove) [0317] XI-24 was prepared from SBr-11 and PhOH-45 in the same manner as that described in Example 28. 'H-NMR (400 MHz, DMSO): 6 13.58 (s, 1H), 8.06 - 7.33 (m, HH),6.25(s, (Figure Remove) [0318] XI-38 was prepared from SBr-5 and PhOH-42 in the same manner as that described in Example 28. (Figure Remove) [0319] XI-41 was prepared from SBr-1 and PhOH-42 in the same manner as that described in Example 28, (Figure Remove) [0320] XI-47 \vas prepared from SBr-5 and PhOH-46 in the same manner as that described in Example 28. 'H-NMR (400 MHz, DMSO): 8 8.22 - 7.45 (m, 11H), 6.42 (s, 1H). (Figure Remove) [0321] XI-50 was prepared from SBr-1 and PhOH-46 in the same manner as that described in Example 28. 'H-NMR (400 MHz, DMSO): 5 8.20 - 7.40 (m, 11H), 6.22 9s, 1H). (Figure Remove) [0322] XI-51 was prepared from SBr-11 and PhOH-46 in the same manner as that described in Example 28, 'H-NMR (400 MHz, DMSO): 5 8.22 - 7.45 (m, 11H), 6.40 (s, 1H). (Figure Remove) [0323] The rest of XI can be prepared from SBr-X and PhOH-X in the same manner as that described in Example 28. (Figure Remove) [0324] XIa-5 was prepared fron i SXI-5 in the same manner as that described in Example 42. 'H NMR (400 MHz, DMSO-^): 6 8.02 (2H, dd, J= 6.8, 3.2 Hz), 7.58 (IH, s), 7.51 (2H, dd, .7-6.8, 3.2 Hz), 7.36 (311, t, ./= 8.8 Hz), 7.24 (2H, d, J= 8.4 Hz), 6.94 (IH, d, J= 8.4 Hz), 2.38 (3H,s), 1.78(3H, ;). (Figure Remove) [0325] XIa-6 was prepared from SXJ-6 in the same manner as that described in Example 42. 'H-NMR (400 MHz, OMSO): 5 8.00 - 6.98 (m, 1 IH), 2.32 (s, 3H), 1.70 (s, 3H). (Figure Remove) (0326] XIa-8 was prepared from SXJ-7 in the same manner as that described in Example 42. 'H NMR (CDC13| 400 MHz) 8 13.41 (br, IH), 8.03 (m, 2H), 7.58 (d, IH), 7.53-7.49 (m, 2H), 7.36 (dd, IH), 7.32 (m, 2H), 7.19 (m, 3H), 6.93 (d, IH), 2.35 (s, 3H), 1.67 (s, 3H). (Figure Remove) [0327] Xla-24 was prepared from SXI-8 in the same manner as that described in Example 42. (Figure Remove) [0328] XIa-51 was prepared from SXI-10 in the same manner as that described in Example 42. . 'H-NMR (400 MHz, DMSO): 5 8.10-7.22 (m, 11H), 2.42 (s, 3H), 1.70 (s, 3H). (Figure Remove) (0329] The rest of XIa-X can be prepared from SXI-11 in the same manner as that described in Example 42. 16. Enaritiomer separation |0330] The enantiomei s of compounds XI and XIa were or can be obtained in the same manner as that decribed in Section 4 and Example 49 to Example 62. (Figure Remove) [0331] Racemic Xl-24 was resolved by chiral HPLC to give (+)-XI-24 and (-)-XI-24. HPLC methods and conditions, including eluents used, solvent flow rate and detection wavelength were: 20% iPrOH-80% Hexanes-0.1% TFA, 30 mL/min., X=220 nm. For (+)-XI-24: RT 4.60 min. For (-)-XI-24: RT 5.11 min. (Figure Remove) (Table Remove) Figure Remove) (0333] PhNH2-2 to PHNH2-7 can be either purchased from different commercial sources or they can be prepared according the literature procedures cited. 19. Synthesis of Compounds XII and Xlla in Table 12 [0334] Compounds XII-X and XHa-X were or can be prepared with SBr-X and PhOH-48 to PhOH-55 and with SBr-X and PhNHz-2 to PhNH2-7 in the same manner as that described for the synthesis of compounds I-X and la-X. (Figure Remove) (Table Remove) 20 J-.> Mthesis of aza-ben/:ooxazole and aza-benzotbiazole phenols and anilines [033SJ The aza-benzooxazole and aza-benzothiazole phenols and anilines used for the preparation of compounds XIII can be prepared in the same manner as that described for the /ynthesis of2-benzooxazol-2-yl- phenols illustrated in Scheme II or by those skilled in the arts. Scheme 7 . Synthesis of aza-benzooxazole and aza-benzothiazole phenols and anilines (Figure Remove) |0337j PhNH2-8 to PhNH2-18 can be prepared according to Scheme? with readily available aza-2-amino-phenols and aza-2-amino-benzenethiol. 21. Synthesis of Compounds XIII in Table 13 [0338] Compounds XIII can be prepared with SBr-X and PhOH-56 to PhOH-66 and with SBr-X an i PhNHj-8 to PhNHb -18 in the same manner as that described for the synthesis of compounds I-X and la-X. (Figure Remove) (Table Remove) 22. Synthesis of compound XIV-X listed in Table 14. [03391 Compounds XIV-X listed in Table 14 were or can be prepared with SBr-14,15,16, 17 and 18 and PhOH-X in the same manner as described in Example 28 Step A. Alternatively, they were or can be prepared from esterification of the corresponding acids in the same manner as that described in Examples 136 to 138. (Figure Remove) |0340] A 500 mL 'three neck roundbottom flask was equipped with an efficient condenser attached to an acid scrubber, a magnetic stir bar, and placed under argon. 4-Chlorophenylacetic acid SI-5 (99.9 g, 0.50 mole) was charged, followed by thionyl chloride (50.0 mL (81.6 g), 0.68 mole). The condenser was cooled with 4°C water. The mixture was heated to an internal temperature of 55-60"C. Gas evolution was observed and the solids dissolved us the internal temperature rose to 55-60°C over 45 min.. The mixture was then stirred at 55-60°C for 45 min.. Bromine (33.0 mL (102.4 g), 0.65 mole) was charged and the mixture maintained at 55-60°C for 18 h. The internal temperature was then raised to 80-85°C over 1.5 h and heating continued for 18h (based on other runs, the reaction is complete after 6-7h). The mixture was cooled to 20-25°C and anhydrous dichloromethane (500 mL) added. In a separate flask was place 2-acetylethanolamine (190 mL (213 g), 2.07 mole) and anhydrous dichloromethane (500 mL) under argon and the mixture cooled to 2.8°C. To this was added the acyl halide solution at such a rate as to keep the internal temperature below 21 °C (caution: exothermic). After the addition was complete (approx. 20 min.), the mixture was stirred in the cold bath for 0.5h, at which time the internal temperature was 4.8 °C. This mixture was carefully added to 1.5 L water containing sodium bicarbonate (148 g, 1.8 mole) at such a rate that frothing was moderate. The pH at the end of the addition (15 min.) was 7, by pH paper. Sodium thiosulfate (18.7 g, 0.12 mole) was added in portions and gas evolution was observed. Bromine was found to be absent at this time by testing with a Peroxid 100 (quantifix) strip. The layers were then partitioned in a separatory funnel (100 mL dichloromethane used in transfer), and the organic phase extracted with 250 mL water, dried over magnesium sulfate (17 g), and filtered. The filter cake was washed with dichloromethane (150 mL). Rotary evaporation and pumping at high vacuum afforded an oil, which was slurried in 100 mL hexane: ethyl acetate (70:30). Additional hexane (300 mL) was added until a white color formed in the top layer of the biphasic mixture. Vigorous agitation afforded a solid, which was filtered away from the supernatant to yield crude (2-acetamidoethyl)-4-chlorophenylbromoacetate SBr-14 (147g) as a light tan solid. (Figure Remove) [0341] SBr-15,16, 17, and 18 were prepared in the same manner as that described in Example 131. (Figure Remove) [0342] In the same manner as that described in Example 28 Step A, compound XIV-1 was prepared from SBr-14 and PhOH-6. (Figure Remove) [0343] In the same manner as that described in Example 28 Step A, compound XIV-2 was prepared from SBr-15 and PhOH-6. (Figure Remove) [0344] In the same manner as that described in Example 28 Step A, compound XIV-11 was prepared from SBr-15 and PhOH-2. 23. Enantiomers Preparation [0345] The enantiomers of compounds XIV-X can be obtained from the corresponding enantiomerically pure acids with esterfication as that described in Example 136, Example 137 and Example 138. Alternatively, it can be obtained from the (+/-) racemic mixture with a chiral HPLC separation as that described in Section 4. (Figure Remove) [0346] A mixture of 1-367 (11.74 g, ee >99.9%), N-acetylethanolamine (13.51 g) and TsOH monohydrate (0.25 g) in toluene (200 mL) was refluxed overnight using a Dean-Stark apparatus. The reaction mixture was concentrated to dryness, water was added, and the resultant mixture was stirred at room temperature for 0.5 h. Filtration and washing with water gave a off-white solid, which was recrystallized from iPrOH-hexanes to give enantiomer 1 as an white solid. 'HNMR (d-DMSO, 400 MHz) 8 8.33 (s, 1H), 8.13 (d, 1H), 8.01 (d, 1H), 7.82-7.65 (m, 6H), 7.48 (m, 2H), 7.30 (d, 1H), 6.48 (s, 1H), 4.16 (m, 1H), 4.02 (m, 1H), 3.27 (m, 1H), 3.18(m, 1H), 1.69(s,3H). (Figure Remove) |0347] A mixture of 1-367 (5.87 g, ee >99.9%), EtOH (150 mL) and TsOH monohydrate (0.125 g) was refluxed overnight. The reaction mixture was concentrated to afford enantiomer 2 as a white solid. 'HNMR (d-DMSO, 400 MHz) 5 8.32 (s, 1H), 8.11 (s, 1H), 8.01 (d, 1H), 7.82-7.65 (m, 5H), 7.48 (m, 2H), 7.30 (d, 1H), 6.48 (s, 1H), 4.08 (m, 2H), 1.02 (m, 3H). (Figure Remove) (0348] To a solution of (+)-I-367 (1.1546 g, 2.58 mmol) in DMF (10 mL) at 0 °C was added K2CO3 (0.3597 g, 2.60 mmol), and then followed by ethyl bromoacetate (0.30 mL, 2.70 mmol). After stirring for 40 min at 0 °C, the reaction mixture was diluted with EtOAc and aq. NH4C1/H2O. The organic layer was washed with aq. NH4C1/H2O, and then brine/water, dried over NajSO,*, concentrated in vacua. Purification via chromatography with EtOAc/hexanes (10% to 30%) to afford enantiomer 3 (1.0211 g, 74%) as a white solid. Chiral HPLC analysis of enantiomer was carried out at X = 220 nm by injecting 10 uL of an approximately a 0.5 mg/mL solution of the sample dissolved in mobile phase onto a 25 cm x 4.6 mm Regis Technologies (R,R) Whelk-O 1 5 urn column with a 1.5 mL/min flow of (3/97/0.1) /PrOH/hexanes/TFA. Under these conditions, enantiomer 3 eluted at 12.3 min, and the corresponding pro-drug ester of 1-368 (- isomer) elutes at 13.1 min (approximate retention times), 'l 1 NMR (400 MHz, CDC13): 5 8.36 (1H, s), 8.26 (1H, d, J= 2.0 Hz), 7.98 (1H, d, J= 7.6 H/;), 7.81 (III, m), 7.69 (1H, d, J= 7.2 Hz), 7.56 (2H, m), 7.46 (1H, m), 7.39 (2H, m), 7.12 (1 H, d, J - 8.4 Hz), 5.98 (1H, s), 4.93 (1H, d, 7= 15.6 Hz), 4.58 (1H, d, J = 15.6Hz),4.14(2H,m), 1.67(3H,t, .7=7.2 Hz) ppm. (Figure Remove) [0349] In the same manner as that described in Example 28 compound 139 was prepared from 139-S1 and 139-S2. !HNMR (400 MHz, DMSO-6): 6 8.20 - 7.22 (m, 12H), 6.50 (s, IK). (Figure Remove) 10350] In the same manner as that described in Example 28 compound 140 was prepared from 140-S1 and 140-S2. 1HNMR (400 MHz, DMSO-d6): 5 7.81 - 6.92 (m, 11H), 5.95 (s, 1H), 3.79 (s,3H), 3.74 (s, 3H). 10351] The two enantiomers of 140 were separated by HPLC. Column: PIRKLE COVALENT, (R, R) Whelk-O 2 10/100, 25 cm x 21.1 mm. Flow: 30 ml/min, 50% iPrOH/Hexanes-0.1% TFA. (Figure Remove) [0352] In the same manner as that desc ribed in Example 28 compound 141 was prepared from 141-S1 and 141-S2. *H NMR (400 MHz, DMSO-c/6): 8 13.40 (br, 1H), 8.08 - 6.93 (m, HH),6.ll(s,1H),3.75(s,3H). [0353] The two enantiomers of 14, 1 were separated by HPLC. Column: PIRKLE COVALENT, (R, R) Whelk-O 2 1 0/100, 25 cm x 21.1 mm. Flow: 30 ml/min, 50% iPrOH/Hcxanes-0.1% TFA. (Figure Remove) 0354] In the same manner as that described in Example 28 compound 142 was prepared from 142-S1 and 142-S2. 'H NMR (400 MHz, DMSO-c/5): 6 8.20 - 6.93 (m, 11H), 6.11 (s, lH),3.75(s,3H). [0355] The two enantiomers were separated by HPLC. Column: PIRKLE COVALENT, (R, R) Whelk-O 2 10/100, 25 cm x 21.1 mm. Flow: 30 ml/min, 50% iPrOH/Hexanes-0.1% TFA. (Figure Remove) 10356] In the same manner as that 'described in Example 28 compound 143 was prepared from 143-S1 and 143-S1. 'H NMR (400 MHz, DMSO-6): 5 8.38 - 6.95 (m, 11H), 6.26 (s, lH),3.75(s,3H). |0357] The two cnantiomci v. -re separated by HPLC. Column: PIRKLE COVALENT, (R, R) Whelk-O 2 1" I'OO, 25 cm t 21.1 mm. Flow: 30 ml/min, 50% iPrOH/Hexanes-0.1% TFA. (Figure Remove) [0358] In the same manner as that described in Example 28 compound 144 was prepared from 144-S1 and 144-S2. !H NMR (400 MHz, DMSO-J6): 5 8.25 - 7.16 (m, 1 IH), 6.23 (s, IH). [0359] The two enantiomers were separated by HPLC. Column: PIRKLE COVALENT, (R, R) Whelk-0 2 10/100, 25 cm x 21.1 mm. Flow: 30 ml/min, 50% iPrOH/Hexanes-0.1% TFA. (Figure Remove) |0360] In the same manner as that described in Example 28 compound 145 was prepared from 145-S1 and 145-S2. 'll NMR (400 MHz, DMSO-6): 6 13.6 (IH, br, COO//), 8.25 (IH, d, .7-2.8 Hz), 8.21 (IH, t, J= 2.0 H2;), 7.88-7.90 (IH, m), 7.79-7.83 (2H, m), 7.69 (IH, d, /= 7.6 Hz), 7.60-7.62 (IH, m), 7.41-7.50 (3H, m), 7.18 (IH, d, J= 9.2 Hz), 6.24 (IH, s)ppm. (Figure Remove) [0361] In the same manner as that described in Example 28 compound 146 was prepared from 146-S1 and 146-S2. 'H NMR (400 MHz, DMSO-J6): 8 13.7 (IH, br, COO//), 8.42 (IH, s), 8.25 (IH, s), 8.02 (IH.. d, J= 9.2 Hz), 7.91 (IH, d, J= 8.0 Hz), 7.84 (IH, d, J= 7.2 Hz), 7.73 (IH, d, J= 7.2 Hz), 7.62 (IH, d, J= 8.4 Hz), 7.39-7.51 (4H, m), 6.38 (IH, s) ppm. (Figure Remove) [0362J In the same manner as that described in Example 28 compound 147 was prepared from 147-S1 and 147-S2. *H NMR (400 MHz, DMSO-rf«): 8 13.5 (IH, br, COO//), 8.16 (IH, s), 7.85-7.87 (IH, m), 7.77-7.80 (IH, m), 7.67 (IH, d, 7= 8.0 Hz), 7.64 (IH, d, J= 3.2 Hz), 7.59 (IH, dd,J = 7.2, 1.2 Hz), 7.39-7.49 (3H, m), 7.13-7.21 (2H, m), 6.08 (IH, s), 3.80 (3H, s)ppm. (Figure Remove) J0363) In the same manner as that described in Example 28 compound 148 was prepared from 148-S1 and 148-S2. NMR (400 MHz, DMSO-d6): 8 13.5 (IH, br, COO//), 8.11 (IH, d, J = 2.8 Hz), 7.86-7.88 (IH, m), 7.81-7,83 (IH, m), 7.65-7.75 (5H, m), 7.41-7.49 (2H, m), 7.23 (IH, d,.7=9.6 Hz), 6.18 (IH, s) pprn. (Figure Remove) [0364] In the same manner as that described in Example 28 compound 149 was prepared from 149-S1 and 149-S2. . 'H NMR (400 MHz, DMSO-rftf): 8 13.7 (IH, br, COO//), 8.41 (IH, s), 8.00 (IH, d, J = 8.0 Hz), 7.90 (IH, d, J = 8.0 Hz), 7.85 (IH, d, J= 7.2 Hz), 7.78 (2H, d, J = 8.6 Hz), 7.73 (2H, d, J = 8.6 Hz), 7.39-7.51 (3H, m), 6.33 (IH, s) ppm. (Figure Remove) [0365] In the same manner as that described in Example 28 compound 150 was prepared from 150-S1 and 150-S2. ]H MMR (400 MHz, DMSO-6): 6 13.5 (IH, br, COOH), 8.23 (IH, d, J = 2.8 Hz), 7.69-7.88 (7H, m), 7.41-7.49 (2H, m), 7.17 (IH, d, J= 9.2 Hz), 6.17 (IH, s)ppm. (Figure Remove) J0366] In the same manner as that described in Example 28 compound 151 was prepared from 151-S1 and 151-S2. 1H NMR (400 MHz, DMSO-^): 6 13.4 (IH, br, COO//), 7.83-7.85 (IH, m'i. 7.77-7.80 (IH, m), 7.66-7.72 (4H, m), 7.62 (IH, d, J = 3.2 Hz), 7.40-7.47 (2H, m), 7.11-7.19 (2H, m), 6.01 (IH, s), 3.81 (3H, s) ppm. (Figure Remove) [0367] In the same manner as that described in Example 28 compound 152 was prepared from 152-S1 and 152-S2. 'H NMR (400 MHz, DMSO-c/tf): 8 13.6 (IH, br, COO//), 8.22 (IH, s), 8.13 (IH, d, J= 2.8 Hz), 7.88-7.90 (IH, m), 7.81-7.83 (IH, m), 7.67-7.71 (2H, m), 7.60-7.62 (IH, m), 7.41-7.49 (3H, m), 7.23 (IH, d, J = 9.2 Hz), 6.24 (IH, s) ppm. [0368] In the same manner as that described in Example 28 compound 153 was prepared from 153-S1 and 153-S2. !H NMR (400 MHz, DMSO-d6): 5 8.09 (d, J=2.4Hz,lH), 7.86 (m,lH), 7.78 (m,lH), 7.67 (m, 3H)., 7.45-7.42 (m,4H), 7.23 (d, 7=9.2 Hz,lH), 6.09 (s.lH), 1.28(s, 9H). (Figure Remove) [0369] In the same manner as that described in Example 28 compound 154 was prepared from 154-S1 and 154-S2. 'H NMR (400 MHz, DMSO-d6): 6 7.83 (m,lH), 7.73 (m, 3H), 7.62 (d, J=2.4 Hz.lH), 7.44 (m,4H), 7.38 (m, IH), 7.15 (m, 2H), 5.96 (s, IH). (Figure Remove) 10370] In the same manner as that described in Example 28 compound 155 was prepared from 155-S1 and 155-S2. 1H NMR (400 MHz, DMSO-d6): 5 7.85 (m, IH), 7.76 (m, 3H), 7.63 (m, IH), 7.55 (m, 2H), 7.44 (m, 2H), 7.17 (m, 2H), 6.03 (s.lH). (Figure Remove) |0371] In the same manner as that described in Example 28 compound 156 was prepared from 156-S1 and 156-S2. 'H NMR (400 MHz, DMSO-d6): 8 8.27 (s,lH), 7.99 (d, .7=2.8 Hz,lH), 7.81-7.75 (m, 2H), 7.71 (m, 2H), 7.63 (d, 7=2.4 Hz,lH), 7.47 (m, 2H), 7.20 (m, 2H), 6.26 (s, IH). (Figure Remove) [0372| In the same manner as that described in Example 28 compound 157 was prepared from 157-S1 and 157-S2. 'H NMR (400 MHz, DMSO-d6): 5 13.40 (s,lH), 8.22 (d, J=2.8 Hz.lH), 7.85 (m.lH), 7.79-7.74 (m, 411), 7.48-7.38 (m, 5H), 7.19 (d,7=9.2 Hz, IH), 6.14 (s, IH). (Figure Remove) [0373] In the same manner as that described in Example 28 compound 158 was prepared from 158-S1 and 158-S2. 'H NMR (400 MHz, DMSO-d6): 8 8.23 (d,J=2.4 Hz,lH), 7.87 (m, IH), 7.79 (m, 4H), 7.58 (m,2H), 7.47-7.4:2 (m,2H), 7.18 (d, .7=9.2 Hz,lH), 6.20 (s,lH). (Figure Remove) [0374] In the same manner as that described in Example 28 compound 159 was prepared from 159-S1 and 159-S2. *H NMR (400 MHz, DMSO-d6): 8 8.32 (s,lH), 8.25 (d, 7=2.4 Hz,lH), 8.03 (d, J=8Hz,lH), 7.83-7.71 (m, 5H), 7.48 (m, 2H), 7.26 (d, J=9.6 Hz,lH), 6.38 (s, IH). (Figure Remove) [0375] In the same manner as that described in Example 28 compound 160 was prepared from 160-S1 and 160-82. 1H NMR (400 MHz, DMSO-d6): 5 13.20 (s.lH), 7.84 (m, IH), 7.76 (m,lH), 7.63 (m, 3H), 7.47-7.40 (m, 2H), 7.17-7.11 (m, 2H), 7.01 (m, 2H), 5.89 (s,lH), 3.79 (s, 3H), 3.75 (s,3H). (Figure Remove) [0376] In the same manner as that described in Example 28 compound 161 was prepared froml61-Sl and 161-S2. 'H NMR (400 MHz, DMSO-d6): 6 8.01 (m,lH), 7.85 (mlH), 7.77 (m,lH), 7.65 (m, 2H), 7.50-7.41 (m,4H), 7.21 (dd, .7=2.8 and 8.8 Hz,lH), 7.13 (d, 7*9.6 Hz,lH), 6.08 (s,lH), 3.80 (s,3H). (Figure Remove) [0377] A mixture of ester 162-S1 (205 mg, 0.42 mmol), 4-fluorophenyl boronic acid (71 mg, 0.51 mmol), Pd(OAc)2 (19 mg, 0.084 mmol), 2M Na2CO3 (0.42 mL) in DMF (9 mL) was stirred overnight at room temperature under nitrogen. The mixture was diluted with EtOAc, filtered, washed with brine, dried, and concentrated. Purification via flash column (hexane/EtOAc 5:1) gave ester 162-S3 as a white solid. 'H NMR (400 MHz, DMSO-d6): 6 8.35 (d, J=2.8Hz,l H), 7.89 (m, 2H), 7.83 (m,3H), 7.74 (m, 2H), 7.59 (m, 2H), 7.45 (m, 2H), 7.28 (m, 3H), 6.38 (s,!H), 4.13 (m, 2H), 1.08 (t, 7=7.2Hz, 3H). [0378] To a solution of the above ester (90 mg) in THF /MeOH (3 mL / 3 mL) was added 1 M LiOH solution (1 mL). The resulting mixture was stirred at room temperature for 0.5 h, quenched with IN aqueous HC1 and concentrated to remove the organic solvents. To the residue was added water. The formed solid was filtered, washed with water, and dried to afford acid 162 (82 mg) as a white solid. [0379] 'H NMR (400 MHz, DMSO-d6): 8 8.35 (d,J=2.4Hz,lH), 7.90-7.78 (m,5H), 7.74 (m,2H), 7.57 (m,2H), 7.48-7.41 (m,2H), 7.32-7.26 (m,3H), 6.23 (s,lH). (Figure Remove) 10380] In the same manner as that described in Example 162 compound 163 was prepared from 163-S1 and 163-S2. !H NMR(400 MHz, DMSO-d6): 8 8.33 (d, .7=2.4 Hz, 1H), 7.90 ((dd, J=2.4 and 8.4 Hz.lH), 7.84 (m.lH), 7.79-7.74 (m, 5H), 7.49-7.36 (m, 5H), 7.29 (m, 3H), 6.16 (s,lH). (Figure Remove) 0381] A mixture of 164-S1 (0.7 g), 2-amino-3-hydroxy-pyridine (0.45 g) and PPA (9.0 e) was heated for Ih at 175 °C under nitrogen. The mixture was then poured into water, basified by adding saturated aqueous NaHGOj solution. The resulting mixture was extracted with EtOAc, washed with brine, dried and concentrated to give phenol 164-S2 as a pale yellow solid (265 rng). Pure product was obtained by recrystallization from MeOH. 'H NMR (400 MHz, DMSO-d6): 8 11.30 (s,lH), 8.58 (m.lH), 8.29 (m,lH), 8.01 ((d, J=2.8Hz,lH), 7.55 (m, 2H), 7.19(d,J=8.4Hz, IH). [0382] A mixture of the above phenol 164-S2 (109 mg), bromide 164-S3 (121 mg), Cs2C03 (172 mg) in DMF was stirred at room temperature for 3 h. The mixture was quenched with saturated aqueous NH/iCl solution, extracted with Et2O. The organic layer was dried and concentrated. Purification via Hash column (hexane/EtOAc 5:1) gave ester 164-S4 as colorless oil. 'H NMR (400 MHz, CDC13): 5 8.64 (m.lH), 8.34 (d,/=2.4Hz,lH), 7.86 (m,lH), 7.76 (m, 2H), 7.47-7.42 (m, 4H), 7.38 (m,lH), 6.93 (d, J=9.2Hz,lH), 5.78 (s,lH), 3.72 (s, 3H). [0383] To a solution of the above ester (40 mg) in THF /MeOH (3 mL / 3 mL) was added 0.08 M LiOH solution (1.5 mL) at 0 °C. The resulting mixture was stirred at 0 °C for 4 h, quenched with 0.5 N aqueous HC1 and concentrated. The residue was extracted with EtOAc and the organic layer was dried and concentrated. Purification via flash column (5% to 20% iPrOH in hexanes containing 0.1 % TFA) gave acid 164 as a white solid (22 mg). 'H NMR (400 MHz, CDC13): 8 8.70 (m.lH), 8.24 (d, J=2.8Hz,lH), 7.98 (m,lH), 7.57 (m, 2H), 7.45-7.38 (m, 5H), 6.85 (d, 7=8.4Hz,lH), 5.75 (s.lH). (Figure Remove) [0384] In the same manner as that described in Example 42 compound 165 was prepared from 165-Sl. !H NMR (400 MHz, DMSO-6): 5 8.32 - 7.22 (m, 1 IH), 1.80 (s, 3H). (Figure Remove) |0385] In the same manner as that described in Example 42 compound 166 was prepared from 166-S1. 'H NMR (400 MHz, DMSO-d6): 6 8.22 (d,J=2.4 Hz,lH), 7.85 (m,lH), 7.79 (m,lH), 7.74 (m,2H), 7.69 (Figure Remove) [0386] In the same manner as that described in Example 42 compound 167 was prepared from 167-S1. 'H NMR (400 MHz, DMSO-d6): 8 8.34 (s,lH), 8.12 (m, H), 7.99 (m, IH), 7.81 (m,lH), 7.73-7.63 (m, 4H), 7.46 (m, 2H), 7.01 (d, J=8.8 Hz, IH), 1.92 (s, 3H). (Figure Remove) 1. [0387] In the same manner as that described in Example 42 compound 168 was prepared from 168-S1. 1H NMR (400 MHz, DMSO-d6): 6 8.31 (s,lH), 8.12 (d, 7=2.4 Hz,lH), 7.95 (m,lH), 7.85 (m,lH), 7.79 (m,lH), 7.74 (m,lH), 7.67 (m,lH), 7.59 (m.lH), 7.48 (m, 2H), 6.89 (d, 7=8.8 Hz,lH), 2.62 (m,lH), 2.40 (m,lH), 0.59 (t, 7=6.8 Hz, 3H). (Figure Remove) [0388] In the same manner as that described in Example 42 compound 169 was prepared from 169-S1. 'H NMR (400 MHz, DMSO-d6): 5 8.14 (s,lH), 7.97 (d, 7=2.8 Hz.lH), 7.91 (d,7=8Hz,lH), 7.79 (m,lH), 7.65 (m,lH), 7.49 (dd, 7=2.8 and 9.2 Hz,lH), 7.48-7.37 (m, 4H), 7.17 (d, 7=9.6 Hz.lH), 6.79 (m,lH), 6.72 (m, 2H), 6.54 (m, 2H), 3.75 (d,7=15.2Hz,!H), 3.54 (d, 7*14.4 Hz,lH). (Figure Remove) [0389] The two enantiomers were isolated by chiral HPLC using a 25 cm x 21.1 mm Regis Technologies (R,R) WHELK-0 2 10/100 column at ambient temperature. The column was eluted with (50/50/0.1) i'PrOH/hexanes/0.1%TFA at a flow of 30 mL/min. (Figure Remove) [0390] The two enantiomers were separated by chiral HPLC using a 25 cm x 21.1 mm Regis Technologies (R,R) WHELK-O 2 10/100 column at ambient temperature. HPLC methods and condition: 25% iPrOH-75% Hexanes-0.1% TFA, 30 mL/min., X=220 nm. (Figure Remove) (0391 ] The two enantiomers were separated by chiral HPLC using a 25 cm x 21.1 mm Regis Technologies (R,R) WHELK-O 2 10/100 column at ambient temperature. HPLC methods and conditions: 25% iPrOH-75% Hexanes-0.1% TFA, 30 mL/min., A==220 nm. (Figure Remove) [0392] The two enantiomers were separated by chiral HPLC using a 25 cm x 21.1 mm Regis Technologies (R,R) WHELK-O 2 10/100 column at ambient temperature. HPLC methods and conditions: 50% iPrOH-50% Hexanes-0.1% TFA, 30 mL/min., X=220 nm. (Figure Remove) [0393] A suspension of (+)-174 (1.80 g, 4.02 mol) in ca. 100 mL of CH3CN was heated until it was a clear solution, then cooled to rt. A solution of aq. NaOH (2N, 2.01 mL, 4.02 mmol) was added, and stripped off solvents in vacuo. The residue was dissolved in water and lyophilized to afford desired sodium salt (1.87 g) as a white solid. *H NMR (400 MHz, DMSO-40: 5 8.33 (1H, s), 8.04-8.07 (2H, m), 7.81 (1H, m), 7.72 (1H, m), 7.59 (3H, m), 7.45 (2H, rn), 7.12 (1H, d, J= 9.2 Hz), 5.51 (1H, s) ppm. (Figure Remove) [0394] To a solution of 2-aminophenol (10.64 g, 0.0975 mol) and Et3N (14.24 mL, 0.102 mol) in CHjCh (200 mL) at 0 °C was added drop wise 2,5-difluoro-benzoyl chloride 174A-Sl (16.39g, 0.093 mol). The resulting mixture was stirred at 0 °C to rt overnight, diluted with EtOAc and washed with IN HC1 and water. The organic layer was dried over Na2SC>4 and concentrated in vacua to afford crude 174A-S2 as a pale yellow solid. !H NMR (400 MHz, DMSO-d6): 8 10.06 (s,!H), 9.52 (d, J=8.0 Hz), 8.0-6.79 (m, 7H). [0395] To a suspension of the above crude product 174A-S2 in toluene (300 mL) was added pTsOH monohydrate (5.0 g). The resulting suspension was refluxed at 120 °C with a Dean-Stark condenser for 16 h. The reaction was cooled to rt, concentrated in vacuo, diluted with EtOAc, washed with sat. NaHCO3 and brine, dried over Na2$O4 and concentrated in vacuo to afford 174A-S3 (18.73g, 87% for two steps) as a pale yellow solid. 1H NMR (400 MHz, DMSO-d6): 8 7.96 (m,lH), 7.85-7.79 (m,2H), 7.56 (m,2H), 7.48-7.40 (m,2H). [0396] To a solution of 174A-S4 (1.88 g, 12.32 mmol) in DMF (30 mL) at 0 °C was added NaH (0.96 g, 24.03 mmol). The resulting mixture was wanned up to rt, and stirred at rt for 1 h. To this reaction mixture was added a solution of 174A-S3 (2.85 g, 12.32 mmol) in DMF (20 mL), and the resulting mixture was heated at 50 °C for 12 hrs. After cooling to r.t., the reaction mixture was quenched with cold 2 N HC1 solutions, extracted EtOAc. The organic layer was washed with H2O, dried over NaaSC^ and concentrated in vacuo. The residue was recrystallized from Et20 to afford 174A as a greenish solid (1.2 g). 'H NMR (400 MHz, DMSO-de): 6 13.38 (br.lH), 7.89-7.83 (m,2H), 7.77-7.72 (m,3H), 7.48-7.37 (m,6H), 7.24 (m.lH), 6.19(s,lH). [0397] The two enantiomers were separated by HPLC. Column: PERKLE COVALENT, (R, R) Whelk-O 2 10/100, 25 cm x 21.1 mm. Flow: 30 ml/min, iPrOH/Hexanes-0.1% TFA. (Figure Remove) 0398] In the same manner as that described in Example 174A compound 174B was prepared from 174A-S3 and 174B-S1. !H NMR (400 MHz, DMSO-d6): 5 13.38 (br.lH), 7.91-7.83 (m,2H), 7.81-7.78 (m,3H), 7.48-7.41 (m,5H), 7.24 (m.lH), 6.15 (s,lH). [0399] The two enantiomers were separated by HPLC. Column: PIRKLE COVALENT, (R, R) Whelk-O 2 10/100, 25 cm x 21.1 mm. Flow: 30 ml/min, iPrOH/Hexanes-0.1% TFA. (Figure Remove) [0400] In the same manner as that described in Example 174A compound 174C was prepared from 174A-S3 and 174C-S1. 1H NMR (400 MHz, CDC13): 5 7.96 (m,lH), 7.86 (m.lH), 7.67 (m,lH), 7.58 (m,lH), 7.48 (m,3H), 7.38 (m,2H), 7.13 (m,lH), 6.81 (m,lH), 5.62 (s,lH). [0401] The two enantiomers were separated by HPLC. Column: PIRKLE COVALENT, (R, R) Whelk-0 2 10/100, 25 cm x 21.1 mm. Flow: 30 ml/min, iPrOH/Hexanes-0.1% TFA. (Figure Remove) [0402) In the same manner as that described in Example 174A compound 174D was prepared from 174A-S3 and 174D-S1. 1H NMR (400 MHz, CDC13): 6 7.93-7.86 (m,2H), 7.66 (m.lH), 7.55-7.46 (m,4H), 7.37-7.33 (m,2H), 7.15 (m.lH), 6.82 (m.lH), 6.18 (s,lH). 104031 The two enantiomers were separated by HPLC. Column: PIRKLE COVALENT, (R, R) Whelk-0 2 10/100, 25 cm x 21.1 mm. Flow: 30 ml/min, iPrOH/Hexanes-0.1% TFA. (Figure Remove) [0404] In the same manner as that described in Example 174A compound 174F was prepared from 174A-S3 and 174F-S1. (Figure Remove) [0405] In the same manner as that described in Example 28 compound 175 was prepared from 175-S1 and 175-S2. 'H NMR (400 MHz, DMSO-rftf): 6 13.4 (IH, br, COO//), 8.80 (IH, s), 8.07 (IH, d, y = 8.0 Hz), 7.86-7.88 (2H, m), 7.78-7.82 (3H, m), 7.60 (IH, td, J = 7.8, 1.2 Hz), 7.55 (IH, s), 7.43-7.75 (5H, m), 7.39 (IH, tt, J= 7.2, 1.2 Hz), 6.21 (IH, s) ppm. (Figure Remove) [0406] In the same manner as that described in Example 28 compound 176 was prepared from 176-S1 and 176-S2, !H NMR (400 MHz, DMSO-dg): 8 8.82 (IH, s), 8.41 (IH, s), 8.09 (2H, t, J= 8.2 Hz), 7.88 (IH, d, J= 8.0 Hz), 7.83-7.86 (IH, m), 1.11-1 W (2H, m), 7.73 (IH, t, J= 7.6 Hz), 1.61 (IH, td, J= 6.8, 1.2 Hz), 7.58 (IH, s), 7.45-7.52 (3H, m), 6.43 (IH, s) ppm. (Figure Remove) [0407] In the same manner as that described in Example 28 compound 177 was prepared from 177-S1 and 177-S2. 'H NMR (400 MHz, DMSO-^): 8 13.5 (IH, br, COO//), 8.00-8.06 (3H, m), 7.78 (IH, dd,J= 9.2, 2.4 Hz), 7.51-7.54 (4H, m), 7.36 (2H, d, J- 8.4 Hz), 7.24 (IH, d, J= 8.8 Hz), 6.07 (IH, s) ppm. (Figure Remove) [0408] In the same manner as that described in Example 28 compound 178 was prepared from 178-SI and 178-S2. 'H NMR (400 MHz, DMSO-^): 6 8.01-8.06 (3H, m), 7.79 (IH, dd,./ = 8.8, 2.8 Hz), 7.51 -7.56 (2H, m), 7.47 (IH, m), 7.35-7.37 (3H, m), 7.25 (IH, d, J = 8.8Hz),6.l3(lH,s)ppm. |0409] In the same manner as that described in Example 28 compound 179 was prepared from 179-S1 and 179-S2. 'l I NMR (400 MHz, DMSO-^): 6 8.03-8.06 (2H, m), 7.94 (IH, d, J = 2.4 Hz), 7.68 (IH, dd, J= 8.8, 2.8 Hz), 7.62 (IH, m), 7.48-7.54 (3H, m), 7.41 (IH, d, J = 7.6 Hz), 7.26-7.32 (2H, m), 6.13 (IH, s) ppm. (Figure Remove) 10410] In the same manner as that described in Example 28 compound 180 was prepared from 180-S1 and 180-S2. 'H NMR (400 MHz, DMSO-d6): 8 8.04 (IH, d, 7= 2.8 Hz), 7.97-8.02 (2H, m), 7.81 (IH, dd, /= 8.8, 2.8 Hz), 7.71-7.73 (2H, m), 7.67 (IH, d, J= 8.2 Hz), 7.58 (IH, d,./= 8.2 Hz), 7.51-7.55 (2H, m), 7.29 (IH, d, J = 8.8 Hz), 6.28 (IH, s) ppm. (Figure Remove) [0411] In the same manner as that described in Example 28 compound 181 was prepared from 181-S1 and 181-S2. 'H NMR (400 MHz, DMSO-rftf): 8 7.98-8.06 (2H, m), 7.98 (IH, d, J- 2.4 Hz), 7.77 (IH, dd, 7= 9.2, 2.4 Hz), 7.50-7.55 (2H, m), 7.34-7.39 (2H, m), » 7.27-7.31 (3H, m), 7.24 (IH, d,./= 8.8 Hz), 6.03 (IH, s) ppm. The two enantiomers were isolated by chiral HPLC using a 25 cm x 21.1 mm Regis Technologies (R,R) WHELK-O 2 10/100 column at ambient temperature. The column was eluted with (15/85/0.1) /PrOH/hexanes/TFA at a flow of 30 mL/min. Detection was at 220 nm. The (+)-181 eluted at 4.0 to 5.3 min, and the (-)-181 at 5.8 to 7.1 min. (Figure Remove) [0412] In the same manner as that described in Example 28 compound 182 was prepared from 182-S1 and 182-S2. 'H NMR (400 MHz, DMSO-rftf): 8 13.5 (IH, br, COOH), 8.04 (2H, q, 7 = 3.2 Hz), 7.91 (IH, d, J= 2.8 Hz), 7.66 (IH, dd, J = 9.2, 2.8 Hz), 7.52-7.54 (4H, m), 7.36 (2H, d, J = 8.4 Hz), 7.29 (IH, d, /= 9.6 Hz), 6.09 (IH, s) ppm. (Figure Remove) [0413] In the same manner as that described in Example 28 compound 183 was prepared from 183-S1 and 183-S2. 'H NMR (400 MHz, DMSO-^): 5 13.3 (IH, br, COOH), 8.02 (2H, q, 7 = 3.2 Hz), 7.48-7.52 (4H, m), 7.32-7.35 (3H, m), 7.21 (IH, d, J= 8.8 Hz), 7.14 (IH, dd, 7 = 9.6, 3.2 Hz), 5.86 (IH, s), 3.77 (3H, s) ppm. (Figure Remove) [0414] In the same manner as that described in Example 28 compound 184 was prepared from 184-S1 and 184-S2. 'H NMR (400 MHz, DMSO-d6): 6 8.04 (m, 2H), 7.88 (d, 7=2.4 Hz, IH), 7.67 (dd, .7-2.8 and 9.2 Hz,lH), 7.53 (m, 2H), 7.38 (m,2H), 7.29 (m,4H), 6.04 (Figure Remove) [0415] In the same manner as that described in Example 28 compound 185 was prepared from 185-S1 and 185-S2. 1H NMR (400 MHz, DMSO-d6): 8 8.02 (m, 2H), 7.96 (d, .7=2.8 Hz, IH), 7.74-7.66 (m, 4H), 7.60-7.51 (m, 3H), 7.37 (d, 7=8.8 Hz,lH), 6.29 (s.lH). (Figure Remove) [0416] In the same manner as that described in Example 28 compound 186 was prepared from 186-S1 and 186-S2. !H NMR (400 MHz, DMSO-d6): 5 8.05 (m, 2H), 7.94 (d, .7=2.8 Hz.lH), 7.69 (dd, 7=2.8 and 8.8 Hz,lH), 7.56-7.52 (m,2H), 7.48 (s,lH), 7.39-7.30 (m, 4H), 6.15(s,lH). (Figure Remove) 10417] In the same manner as that described in Example 28 compound 187 was prepared from 187-S1 and 187-S2. *H NMR (400 MHz, DMSO-d6): 5 8.04 (m, 2H), 7.67 (m.lH), 7.57 (m,lH), 7.50 (m, 2H), 7.40 (m, 2H), 7.28 (m, 3H), 7.17 (m,lH), 5.94 (s.lH), 1.30 (s,9H). (Figure Remove) [0418] In the same manner as that described in Example 28 compound 188 was prepared from 188-S1 and 188-S2. 'H NMR (400 MHz, CDC13): 8 8.18 (d, J=2.4 Hz, 1H), 8.01 (m, 2H), 7.69 (m, 4H), 7.54 (m, 2H), 7.44 (dd, J=2.4 and 8.8Hz,lH), 6.97 (d, >8Hz,lH), 5.91 (s,lH),l.39(s,9H). (Figure Remove) J0419] In the same manner as that described in Example 28 compound 189 was prepared from 189-S1 and 189-S2. !H NMR (400 MHz, DMSO-d6): 6 8.0 (m,2H), 7.94 (d, J-2.8Hz,lH), 7.74 (dd, 7=2.4 and 8.8Hz,lH), 7.52 (m,2H), 7.34 (m,4H), 7.19 (d, J=8.8Hz,lH), 5.97 (s,lH). (Figure Remove) (0420) In the same manner as that described in Example 28 compound 190 was prepared from 190-S1 and 190-S2. ' H NMR (400 MHz, DMSO-d6): 6 8.04 (m, 2H), 7.52 (m, 2H), 7.36(m, 2H), 7.33 (d, J-3.2 Hz,lH), 7.27 (m,3H), 7.21 (d, J=8.8 Hz,lH), 7.13 (dd, J=3.2 and 9.2Hz,lH), 5.82 (s.lH), 3,79 (s, 3H). (Figure Remove) [0421 j In the same manner as that described in Example 28 compound 191 was prepared from 191-S1 and 191-S2. !H NMR (400 MHz,CDCl3): 8 8.12 (d, J=2.4 Hz.lH), 8.01 (m,2H), 7.54 (m, 2H), 7.42 (m, 3H), 7.06 (d, >8.8Hz,lH), 6.90 (d, 7=8.8Hz, 2H), 5.82 ), 3.79(s,3H), 1.38(s, 9H). (Figure Remove) [04221 In the same manner as that described in Example 28 compound 192 was prepared from 192-S1 and 192-S2. !H NMR (400 MHz, DMSO-d6): 6 8.04 (m, 2H), 7.69 (d, 7=2.8 Hz,lH), 7.58 (dd, 7=2.4 and 8.8Hz,lH), 7.51 (m, 4H), 7.36 (m, 2H), 7.15 (d, J=8.8Hz,lH), 5.97 (s,lH), 1.30(s,9H). (Figure Remove) [0423] In the same manner as that described in Example 28 compound 193 was prepared from 193-Sl and 193-S2. 'H NMR (400 MHz, DMSO-d6): 6 8.05 (m,2H), 7.87 (d, J=2.8 Hz,lH), 7.67 (dd, J=2.8 and 8.8Hz,lH), 7.52 (m,2H), 7.31 (m,5H), 5.99 (s,!H), 1.21 (s,9H). (Figure Remove) [0424] In the same manner as that described in Example 28 compound 194 was prepared from 194-S1 and 142-S2. 'H NMR (400 MHz, DMSO-d6): S 8.04 (m,2H), 7.65 (d, 7=2.8 Hz.lH), 7.48 (dd, J=2.8 and 8.8Hz,lH), 7.51 (m, 2H), 7.30 (m, 4H), 7.18 (d, J=8.8Hz,lH), 5.89(s, 1H), 1.30 (s,9H), 1.23 (s,9H). (Figure Remove) 1. [0425] In the same manner as that described in Example 28 compound 195 was prepared from 195-S1 and 195-S2. !H NMR (400 MHz, DMSO-d6): 8 8.03 (m, 2H), 7.52 (m, 2H), 7.38 (m, 5H), 7.21 (d, .7-8.8 Hz,lH), 7.14 (dd, J-2.8 and 9.6Hz,lH), 5.87 (s,lH), 3.77(s,3H). (Figure Remove) [0426] In the same manner as that described in Example 28 compound 196 was prepared from 196-SI and 196-S2. 'H NMR (400 MHz, DMSO-d6): 5 8.05 (m,2H), 7.97 (d, J=2.8 Hz,lH), 7.76 (dd,y=2.4 and 9.2Hz,lH), 7.54 (m, 2H), 7.36 (m, 2H), 7.31 (m, 4H), 7.24 (d, ./=3.2Hz,lH), 5.99 (s.lH), 1.22 (s, 9H). (Figure Remove) [0427] In the same manner as that described in Example 28 compound 197 was prepared from 197-S1 and 197-S2. 'H NMR (400 MHz, CDC13): 8 8.39 (m,lH), 7.98 (m, 2H), 7.67 (m, 4H), 7.55 (m, 2H), 7.48 (m.lH), 6.88 (d,/=8.8 Hz.lH), 5.87 (s.lH). (Figure Remove) [0428] In the same manner as that described in Example 28 compound 198 was prepared from 198-Sl and 198-S2. 'H NMR (400 MHz, DMSO-6): 5 8.0-7.0 (m, 16H), 6.0 (s, 1H), 2.26 (s, 3H). (Figure Remove) [0429] In the same manner as that described in Example 28 compound 199 was prepared from 199-S1 and 199-S2. !H NMR (400 MHz, DMSO-6): 5 8.06-7.33 (m, 11H), 6.24 (s, 1H). [0430] The two enantiomers were separated by HPLC. Column: PIRKLE COVALENT, (R, R) Whelk-0 2 10/100, 25 cm x 21.1 mm. Flow: 30 ml/min, 8% iPrOH/Hexanes-0.1% TFA. (Figure Remove) [0431] In the same manner as that described in Example 28 compound 200 was prepared from 200-S1 and 200-S2. !H NMR (400 MHz, DMSO-rf6): 5 8.05-7.28 (m, 16H), 6.09 (s, 1H). (Figure Remove) [0433] In the same manner as that described in Example 28 compound 201 was prepared from201-Sl and201-S2. !H NMR (400 MHz, DMSO-d6): 5 8.03-7.16 (m, llH),5.94(s, 1H), 3.78 (s, 3H). [0434] The two enantiomers were separated by HPLC. Column: PIRKLE COVALENT, (R, R) Whelk-0 2 10/100, 25 cm x 21.1 mm. Flow: 30 ml/min, 15% iPrOH/Hexanes-0.1% TFA. (Figure Remove) (0435] In the same manner as that described in Example 28 compound 202 was prepared from 202-S1 and 202-S2. !H NMR (400 MHz, DMSO-rf6): 6 7.99 -7.16 (m, 1IH), 6.08 (s, lH),3.78(s,3H). [0436] The two enantiomers were separated by chiral HPLC. Column: PIRKLE COVALENT, (R, R) Whelk-0 2 10/100, 25 cm x 21.1 mm. Flow: 30 ml/min, 8% iPrOH/Hexanes-0.1% TFA. (Figure Remove) (0437] In the same manner as that described in Example 28 compound 203 was prepared from 203-S1 and 203-S2. !H NMR (400 MHz, DMSO-J6): 8 8.04 -7.16 (m, 11H), 5.94 (s, 1H), 3.78 (s, 3H). [0438] The two enantiomers were separated by chiral HPLC. Column: PIRKLE COVALENT, (R, R) Whelk-O 2 10/100, 25 cm x 21.1 mm. Flow: 30 ml/min, 15% iPrOH/Hexanes-0.1% TFA. (Figure Remove) [0439] In the same manner as that described in Example 28 compound 204 was prepared from 204-S1 and 204-S2. ]H NMR (400 MHz, DMSO-J6): 6 8.17 -7.29 (m, 12H), 6.20 (s, 1H). [0440] The two enantiomers were separated by chiral HPLC. Column: PIRKLE COVALENT, (R, R) Whelk-O 2 10/100, 25 cm x 21.1 mm. Flow: 30 ml/min, 10% iPrOH/Hexanes-0.1% TFA. (Figure Remove) [0441] In the same manner as that described in Example 28 compound 205 was prepared from 205-S1 and 205-S2. !H NMR (400 MHz, DMSO-6): & 8.04 -7.27 (m, 12H), 5.96 (s, 1H). [0442] The two enantiomers were separated by chiral HPLC. Column: PERKLE COVALENT, (R, R) Whelk-O 2 10/100, 25 cm x 21.1 mm. Flow: 30 ml/min, 15% iPrOH/Hexanes-0.1 %TFA. (Figure Remove) [0443] In the same manner as that: described in Example 28 compound 206 was prepared from 206-S1 and 206-S2. 'H NMR (400 MHz, DMSO-d6): 5 8.03 -7.29 (m, 11H), 6.01(s, 1H). (Figure Remove) [0444] In the same manner as that described in Example 28 compound 206A was prepared from 20A6-S1 and 206A-S2. (Figure Remove) [0445] In the same manner as that described in Example 42 compound 207 was prepared from 207-S1. 'H NMR (400 MHz, DMSO-J6): 6 8.05-7.08 (m, 11H), 1.76 (s, 3H). [0446] The two enantiomers of 207 were separated by HPLC. Column: PIRKLE COVALENT, (R, R) Whelk-O 2 10/100, 25 cm x 21.1 mm. Flow: 8 ml/min, 15% iPrOH/Hexanes-0.1% TFA. (Figure Remove)] |0447] lr he same manner as that described in Example 42 compound 208 was prepared from 208-SI. 'H NMR (400 MHz, DMSO-6): 5 8.06-7.03 (m, 16H), 1.72 (s, 3H). [0448] The two enantiomers were separated by HPLC. Column: PIRKLE COVALENT, (R, R) Whdk-0 2 10/100, 25 cm x 21.1 mm. Flow: 30 ml/min, 8% iPrOH/Hexanes-0.1% TFA. (Figure Remove) [0449] In the same manner as that described in Example 42 compound 209 was prepared from 209-S1. !H NMR (400 MHz, DMSO-rf6): 5 13.7 (1H, br, COO//), 8.05 (2H, q, J= 2.8 Hz), 7.94 (IH, d, J= 2.4 Hz), 7.63 (IH, dd, J = 8.8, 2.8 Hz), 7.52-7.55 (2H, m), 7.40-7.42 (2H, m), 7.32-7.35 (2H, m), 7.04 (IH, d, J- 8.8 Hz), 1.72 (3H, s) ppm. [0450] In the same manner as that described in Example 42 compound 210 was prepared from 210-S1. *H NMR (400 MHz, DMSO-cfc): 5 13.4 (IH, br, COO//), 8.01 (2H, q, J= 2.8 Hz), 7.49-7.52 (2H, m), 7.35-7.37 (3H, m), 7.26-7.28 (2H, m), 7.15 (IH, dd, J= 8.8, 3.0 Hz), 7.04 (IH, d, J- 8.8 Hz), 3.79 (3H, s), 1.56 (3H, s) ppm. (Figure Remove) |0451] In the same manner as that described in Example 42 compound 211 was prepared from 211-S1. !H NMR (400 MHz, DMSO-rf (Figure Remove) [0452] In the same manner as that described in Example 42 compound 212 was prepared from 212-S1. 'H NMR (400 MHz, DMSO-d6): 6 8.0 (m, 2H), 7.81 (m,lH), 7.54 (m,3H), 7.34 (m,2H), 7.15 (d, 7=9.2 Hz,lH), 7.08 (m,3H), 1.62 (s,3H). (Figure Remove) [0453] In the same manner as that described in Example 42 compound 213 was prepared from 213-S1. 'H NMR (400 MHz, DMSO-d6): 5 8.0 (m, 2H), 7.95 (m,lH), 7.69-7.61 (m, 5H), 7.53 (m, 3H), 1.82(s, 3H). (Figure Remove) [0454] In the, same manner as that described in Example 42 compound 214 was prepared from 214-S1 'H NMR (400 MHz, DMSO-d6): 6 8.06 (m,2H), 7.76 (dd, 7=2.8 and 9.2 Hz,lH), 7.54 (m, 2H), 7.41 (m, 2H), 7.26 (m, 2H), 6.99 (d, J=9.2Hz,lH), 1.72 (s, 3H). (Figure Remove) [0455] In the same manner as that described in Example 42 compound 215 was prepared from 215-S1. 'H NMR (400 MHz, DMSO-d6): 5 8.02 (m, 2H), 7.51 (m.lH), 7.32 (d, .7=2.8 Hz, 1H), 7.28 (m, 2H), 7.14 (m, 4H), 7.04 (d, J=8.8 Hz,lH), 7.38 (s, 3H), 1.57 (s, 3H). (Figure Remove) [0456] In the same manner as that described in Example 42 compound 216 was prepared from 216-S1. 'H NMR (400 MHz, DMSO-d6): 5 8.21 (m,lH), 8.09 (m, 2H), 7.95 (m,lH), 7.56 (m, 2H), 7.45(m, 4H), 7.19 (d, ,7=9.2 Hz,lH), 1.82 (s, 3H). (Figure Remove) 10457] In the same manner as that described in Example 42 compound 217 was prepared from 217-S1. 'H NMR (400 MHz, DMSO-d6): 8 8.05 (m, 2H), 7.68 (d, .7=2.8 Hz,lH), 7.15 (dd, J=2.8 and 8.8 Hz.lH), 7.52 (m, 2H), 7.22 (m, 2H), 7.17 (m, 2H), 6.97 (d, .7=8.8 Hz,lH), 1.68 (s, 3H), 1.30 (s, 9H), 1.19 (s, 9H). (Figure Remove) [04581 1° tne same manner as that described in Example 42 compound 218 was prepared from 218-S1. 'H NMR (400 MHz, DMSO-d6): 6 8.05 (m, 2H), 7.72 (d, 7=2.4 Hz,lH), 7.54 (m, 2H), 7.48 (dd, .7=2.4 and 8.8 Hz.lH), 7.28 (m, 2H), 7.21 (d, 7=8.8 Hz,lH), 7.03 (m, 2H), 1.60(s,3H), 1.21 (s, 9H). (Figure Remove) [0459] In the same manner as that described in Example 42 compound 219 was prepared from 219-S1. 'li NMR (400 MHz, DMSO-d6): 5 8.02 (m, 2H), 7.83 (d, 7=2.8 Hz,lH), 7.67 (dd,7=2.4 and 9.2Hz,lH), 7.53 (m, 2H), 7.18 (m, 2H), 7.04 (m, 3H), 1.58 (s, 3H), 1.12 (s, 9H). (Figure Remove) [0460] The two enantiomers of 220 were isolated by chiral HPLC using a 25 cm x 21.1 mm Regis Technologies (R,R) WHELK-0 2 10/100 column at ambient temperature. The column was eluted with (15/85/0.1) /PrOH/hexanes/TFA at a flow of 30 mL/min. Detection was at 220 nm. Chiral HPLC analysis of enantiomer was carried out at X = 220 nm by injecting 10 fiL of an approximately a 0.5 mg/mL solution of the sample dissolved in mobile phase onto a 25 cm x 4.6 mm Regis Technologies (R,R) Whelk-O 1 5 um column with a 1.5 mL/min flow of (15/85/0.1) /PrOH/hexanes/TFA. (Figure Remove) [0461] In the same manner as that described in Example 220 compounds (+)-221 and (-)-221 were prepared from 221. 'HNMR(400MHz, DMSO-6): 5 8.18-7.25 (m, 11H), 1.72 (s, 3H). (Figure Remove) [0462) The two enantiomers were isolated by chiral HPLC using a 25 cm x 21.1 mm Regis Technologies (R,R) WHELK-0 2 10/100 column at ambient temperature. The column was elutecl with (15/85/0.1) /PrOH/hexanes/TFA at a flow of 30 mL/min. Detection was at 220 nm. One enantiomer eluted at 3.8 to 4.7 min, and the other enantiomer at 5.1 to 6.1 min. Chiral HPLC analysis of enantiomer was carried out at X = 220 nm by injecting 10 \iL of an approximately a 0.5 mg/mL solution of the sample dissolved in mobile phase onto a 25 cm x 4.6 mm Regis Technologies (R,R) Whelk-O 1 5 jam column with a 1.5 mL/min flow of (15/85/0.1) /PrOH/hexanes/TFA. Under these conditions, one enantiomer eluted at 4.7 min, the other enantiomer at 6.6 min. (Figure Remove) [0463] The two enantiomers were isolated by chiral HPLC using a 25 cm x 21.1 mm Regis Technologies (R,R) WHELK-0 2 10/100 column at ambient temperature. The column was eluted with (15/85/0.1) zPrOH/hexanes/TFA at a flow of 30 mL/min. Detection was at 220 nm. One enantiomer eluted at 3.6 to 4.8 min, and the other enantiomer at 5.5 to 6.9 min. Chiral HPLC analysis of enantiomer was carried out at A, = 220 nm by injecting 10 )aL of an approximately a 0.5 mg/mL solution of the sample dissolved in mobile phase onto a 25 cm x 4.6 mm Regis Technologies (R,R) Whelk-O 1 5 um column with a 1.5 mL/min flow of (15/85/0.1) jPrOH/hexanes/TFA. Under these conditions, one enantiomer eluted at 5.0 min, and the other enantiomer at 7.1 min. (Figure Remove) |0464] The two enantiomers were isolated by chiral HPLC using a 25 cm x 21.1 mm Regis Technologies (R,R) WHELK-O 2 10/100 column at ambient temperature. The column was eluted with (15/85/0.1) fPrOH/hexanes/TFA at a flow of 30 mL/min. Detection was at 220 nm. One enantiomer eluted at 3.6 to 4.6 min, and the other enantiomer at 5.1 to 6.0 min. Chiral HPLC analysis of enantiomer was carried out at X = 220 nm by injecting 10 uL of an approximately a 0.5 mg/mL solution of the sample dissolved in mobile phase onto a 25 cm x 4.6 mm Regis Technologies (R,R) Whelk-O 1 5 um column with a 1.5 mL/min flow of (15/85/0.1) /PrOH/hexanes/TFA. Under these conditions, one enantiomer eluted at 4.6 min, and the other enantiomer at 6.4 min. [0465] The two enantiomers were isolated by chiral HPLC using a 25 cm x 21.1 mm Regis Technologies (R,R) WHELK-0 2 10/100 column at ambient temperature. The column was eluted with (25/75/0.1) /PrOH/hexanes/TFA at a flow of 30 mL/min. Detection was at 220 nm. One enantiomer eluted at 4.8 to 6.2 min, and the other enantiomer at 7.3 to 9.2 min. Chiral HPLC analysis of enantiomer was carried out at X - 220 nm by injecting 10 u,L of an approximately a 0.5 mg/mL solution of the sample dissolved in mobile phase onto a 25 cm x 4.6 mm Regis Technologies (R,R) Whelk-0 1 5 urn column with a 1.5 mL/min flow of (25/75/0.1) /PrOH/hexanes/TFA. Under these conditions, one enantiomer eluted at 6,0 min, and the other enantiomer at 9.5 min. (Figure Remove) [0466] The two enantiomers were isolated by chiral HPLC using a 25 cm x 21.1 mm Regis Technologies (R,R) WHELK-0 2 1,0/100 column at ambient temperature. The column was eluted with (25/75/0.1) iPrOH/hexanes/TFA at a flow of 30 mL/min. Detection was at 220 nm. One enantiomer eluted at 4.5 lo 5.5 min, and the other enantiomer at 6.6 to 7.3 min. Chiral HPLC analysis of enantiomer was carried out at X = 220 nm by injecting 10 LiL of an approximately a 0.5 mg/mL solution of the sample dissolved in mobile phase onto a 25 cm x 4.6 mm Regis Technologies (R,R) Whelk-0 1 5 urn column with a 1.5 mL/min flow of (25/75/0.1) /PrOH/hexanes/TFA. Under these conditions, one enantiomer eluted at 5.7 min, and the other enantiomer at 8.6 min. (Figure Remove) |0467] The two enantiomers were isolated by chiral HPLC using a 25 cm x 21.1 mm Regis Technologies (R,R) WHELK-O 2 10/100 column at ambient temperature. The column was eluted with (10/90/0.1) /PrOH/hexanes/TFA at a flow of 30 mL/min. Detection was at 220 nm. One enantiomer eluted at 4.8 to 5.5 min, and the other enantiomer at 6.1 to 6.9 min. Chiral HPLC analysis of enantiomer was carried out at A, = 220 nm by injecting 10 LiL of an approximately a 0.5 mg/mL solution of the sample dissolved in mobile phase onto a 25 cm x 4.6 mm Regis Technologies (R,R) Whelk-O 1 5 Lim column with a 1.5 mL/min flow of (15/85/0.1) j'PrOH/hexanes/TFA. Under these conditions, one enantiomer eluted at 4.9 min, and the other enantiomer at 6.5 min. (Figure Remove) [0468] The two enantiomers were isolated by chiral HPLC using a 25 cm x 21.1 mm Regis Technologies (R,R) WHELK-O 2 10/100 column at ambient temperature. The column was eluted with (10/90/0.1) /PrOH/hexanes/TFA at a flow of 30 mL/min. Detection was at 220 nm. One enantiomer eluted at 4.7 to 5.3 min, and the other enantiomer at 6.2 to 6.9 min. Chiral HPLC analysis of enantiomer was carried out at A. = 220 nm by injecting 10 LiL of an approximately a 0.5 mg/mL solution of the sample dissolved in mobile phase onto a 25 cm x 4.6 mm Regis Technologies (R,R) Whelk-O 1 5 nm column with a 1.5 mL/min flow of (15/85/0.1) /PrOH/hexanes/TFA. Under these conditions, one enantiomer eluted at 4.9 min, and the other enantiomer at 6.8 min. [0469) The two enantiomers were isolated by chiral HPLC using a 25 cm x 21 .1 mm Regis Technologies (R,R) WHELK-0 2 10/100 column at ambient temperature. The column was eluted with (5/95/0. 1 ) jPrOH/hexanes/TFA at a flow of 30 mL/min. Detection was at 220 nm. One enantiomer eluted at 6.2 to 7.2 min, and the other enantiomer at 7.6 to 8.6 min. Chiral HPLC analysis of enantiomer was carried out at X - 220 nm by injecting 10 ^L of an approximately a 0.5 mg/mL solution of the sample dissolved in mobile phase onto a 25 cm x 4.6 mm Regis Technologies (R,R) Whelk-0 1 5 urn column with a 1 .5 mL/min flow of (15/85/0.1) /PrOH/hexanes/TFA. Under these conditions, one enantiomer eluted at 4.1 min, and the other enantiomer at 5.0 min. (Figure Remove) [0470J The two enantiomers were separated by chiral HPLC using a 25 cm x 21.1 mm Regis Technologies (R,R) WHELK-O 2 10/100 column at ambient temperature. HPLC methods and conditions: 20% iPrOH-80% Hexanes-0.1% TFA, 30 mL/min., X.-220 nm. For (+)-enantiomer: RT 3.92 min. [a]d= +7.9 in acetone. For (-)-enantiomer: RT 5.0 min. (Figure Remove) [0471] To a solution of 231 (1.05 g, 2.77 mol, 98% ee) in ca. 10 mL of THF was added 2N aq. NaOH (1.384 mL, 2.77 mmol) with stirring, and then diluted with heptane (50 mL), After removal of solvents in vacua, the residue was dissolved in 5 mL of THF and then diluted with 30 mL of heptanes. After stripping off THF and most of heptanes in vacua, the resulting white precipitate was filtered and rinsed with heptane twice to afford desired sodium salt (1.06 g, 96%, 98+% ee) as a white solid. *H NMR (400 MHz, DMSO-d6): 5 8.02 (2H, dd, J = 6.8, 3.2 Hz), 7.79 (IH, d, J= 2.8 Hz), 7.58 (IH, dd, /= 9.2, 2.8 Hz), 7.51 (2H, dd, /= 6.8, 3.2 Hz), 7.34-7.37 (2H, m), 7.17 (IH, d,J= 9.2 Hz), 7.11 (3H,m), 5.26 (IH, s) ppm. (Figure Remove) [0472] In the same manner as that described in Example 231 different salts of compound 232 M salts were prepared. (Figure Remove) [0473] The two enantiomers were separated by chiral HPLC using a 25 cm x 21.1 mm Regis Technologies (R,R) WHELK-0 2 10/100 column at ambient temperature. HPLC methods and conditions: 15% iPrOH-85% Hexanes-0.1% TFA, 30 mL/min., A=220 nm. One enantiomer: RT 4.0 miri. The other enantiomer: RT 4.8 min. (Figure Remove) [0474] The two enantiomers were separated by chiral HPLC using a 25 cm x 21.1 mm Regis Technologies (R,R) WHELK-0 2 10/100 column at ambient temperature. HPLC methods and conditions: 8% iPrOH-92% Hexanes-0.1% TFA, 30 mL/min., ?.=220 nm. One enantiomer: RT 5.8 min. The other enantiomer: RT 6.4 min. (Figure Remove) [0475] The two enantiomers were separated by chiral HPLC using a 25 cm x 21.1 mm Regis Technologies (R,R) WHELK-0 2 10/100 column at ambient temperature. HPLC methods and conditions: 15% iPrOH-85% Hexanes-0.1% TFA, 30 mL/min., X=220 nm. One enantiomer: RT 4.5 min. The other enantiomer: RT 5.3 min. (Figure Remove) (0476] The two enantiomers were separated by chiral HPLC using a 25 cm x 21.1 mm Regis Technologies (R,R) WHELK-0 2 10/100 column at ambient temperature. HPLC methods and conditions: 15% iPrOH-85% Hexanes-0.1% TFA, 30 mL/min., A,=220 nrn. One enantiomer: RT 4.0 min. The other enantiomer: RT 5.0 min. (Figure Remove) [0477] The two enantiomers were separated by chiral HPLC using a 25 cm x 21.1 mm Regis Technologies (R,R) WHELK-0 2 10/100 column at ambient temperature. HPLC methods and conditions: 25% iPrOH-75% Hexanes-0.1% TFA, 30 mL/min., 1=220 nm. One enantiomer: RT 3.5 min. The other enantiomer: RT 4.2 min. (Figure Remove) [0478] The two enantiomers were separated by chiral HPLC using a 25 cm x 21.1 mm Regis Technologies (R,R) WHELK-0 2 10/100 column at ambient temperature. HPLC methods and conditions: 20% iPrOH-80% Hexanes-0.1% TFA, 30 mL/min., X=220 nm. One enantiomer: RT 4.2 min. The other enantiomer: RT 5.3 min. (Figure Remove) ), 239-S2 (5.06 g) with Cs2CO3 (12 g) in CH3CN was stirred for 12 hours. The salt was filtered off. The filtrate was concentrated, and purified with chromatography (hexane/ethyl acetate 10:1) gave 239-S3 (3.2 g) as a colorless oil.'H NMR (400 MHz, CDC13): 5 8.01 -7.26 (m, 11H), 6.1 l(s, 1H), 3.49 (d, 2H). (Figure Remove) (0480] A solution of 239-S3 (2.0 g), Bu3SnN3 (1.7 mL) in THF was refluxed overnight, then concentrated, and treated with IN HC1. The solution was extracted with ethyl acetate, dried and concentrated. Purification with chromatography (ethyl acetate) gave 239 (0.64 g) as a white solid. 'HNMR(400MHz, CDCh): 6 8.08 -7.15 (m, 11H), 6.86(s, 1H). (Figure Remove) [0481 ] A solution of 240-S1 (1.1 g), GDI (0.56 g) in THF was stirred for half an hour at 60 °C. After cooling down, sulfonyl amide (0.33 g) and DBU (0.65 mL) was added. The reaction mixture was stirred overnight, concentrated, diluted with ethyl acetate, washed with HC1 (0.5 N), and dried. The solvent was removed, and the residue was purified by chromatography (ethyl acetate) to give 240 (1.16 g) as a white solid.'H NMR (400 MHz, CDC13): 6 11.92 (s, 1H), 8.23 - 6.88 (m, 12H), 5.85 (s, 1H), 3.32 (s, 3H). (Figure Remove) [0482] In the same manner as that described in Example 240 compound 241 was prepared from 241-S1. !H NMR (400 MHz, CDC13): 5 12.57 (s, 1H), 8.24 - 6.93 (m, 12H), 5.89 (s, lH),4.22(m,2H). (Figure Remove) [0483] In the same manner as that described in Example 240 compound 242 was prepared from 242-S1. *H NMR (400 MHz, CDC13): 8 11.77 (s, 1H), 8.23 - 6.90 (m, 12H), 5.89 (s, 1H), 3.46 (m,2H), 1.32 (t,3H). (Figure Remove) [04841 In tne same r; lanner ns that described in Example 240 compound 243 was prepared from 243-S1. 'll NMR (400 MHz, CDC13): 5 11.77 (s, 1H), 8.23-6.90 (m, 12H), 5.85 (s, 1H), 3.42 (m, 2t i), 1.80 (m, 2H), 0.98 (t, 3H). (Figure Remove) [04'. product. 'H NMR (400 MHz, CDCb): 5 0.95 (br, 1H), 8.05 - 6.96 (m, 12H), 5.71 (s, 1H), 5.63 (br, 1H). (Figure Remove) [0486] In the same manner as that described in Example 28 compound 245 was prepared from 245-S1 and 245-S2. 'HNMR (400 MHz, DMSO-d6) 6 8.74 (d, J=l .6 Hz, 1H), 7.86 (d, J-2.4HZ, 1H), 7.52-7.35 (in, 7H), 7.14 (d, J=8.8Hz,lH), 6.21 (s, 1H). (Figure Remove) [04871 A solution of 6-chlorochromone 246-S1 (5.57 g, 29.91 mmol), ethylhydrazine oxalate (4.58 g, 29.91 mmol) and Et3N (10.40 mL, 74.77 mmol) in EtOH (60 mL) was refluxed overnight. The mixture was concentrated, dissolved in EtOAc, washed with 1 N HCI and brine, dried and concentrated. Purification via flash column (hexane/EtOAc 10:1 to 3:1) gave 246A (1.3 g) and 246B (5.13 g) as white solids, respectively. For 246A: !H NMR (400 MHz, CDC13): 8 7.61 (d,>1.6 Hz.lH), 7.31 (dd, .7=2.4 and 8.8 Hz, 1H), 7.18 (d, .7=2.8 Hz,lH), 6.97 (m,lH), 6.33 (d, .7-2.0 Hz, 1H), 6.27 (s, 1H), 4.07 (q, .7=7.2 Hz, 2H), 1.36 (t, J=7.2 Hz,3H). For 246B: !H NMR (400 MHz, CDC13): 5 10.90 (s,lH), 7.51 (d,J=2.4Hz,lH), 7.45 (d,.7=2.0 H/,1H), 7.15 (dd, J=2.4 and 8.8 Hz, 1H), 6.95 (d,.7=8.8 Hz,lH), 6.58 (d, y=2.8Hz,lH), '.22 (q,.7-7.2 Hz,2H), 1.54 (t, .7=7.2 Hz,3H). (Figure Remove) J0488] In the same manner as that described in Example 246 compounds 247A and 247B were prepared from 247-S1. For 247A: 1H NMR (400 MHz, CDCl3): 6 7.61 (d, ,7=1.6 Hz,lH), 7.31 (dd, J=2.4 and '8.8 Hz, 1H), 7.19 (d, J=2.8 Hz.lH), 6.95 (m,lH), 6.36 (d, .7=2.0 Hz,lH),3.80(s,3H). (04891 For 247B: !H NMR (400 MHz, CDC13): 8 10.80 (s.lH), 7.50 (d, J=2.4Hz,lH), 7.41 (d, J=2.0 Hz.lH), 7.13 (dd, J=2.4 and 8.8 Hz, 1H), 6.95 (d, >8.8 Hz,lH), 6.58 (d, >2.4Hz,lH),3.98(s,3H). (Figure Remove) [0490] In the same manner as that described in Example 246 compounds 246A and 246B were prepared from 248-S1. For 248A: 1H NMR (400 MHz, CDC13): 8 7.77 (d, 7=2.0 Hz.lH), 7.35-7.26 (m, 5H), 7.20 (dd, .7=2.4 and 8.8 Hz, IH), 7.02 (d, 7=2.8 Hz,lH), 6.80 (d, 7=8.8 Hz,lH), 6.55 (d, 7=2.0Hz,lH), 5.90 (s.lH). For 248B: *H NMR (400 MHz, CDC13): 8 10.90 (s,lH), 8.01 (d, 7=2.4Hz,lH), 7.70 (m, 2H), 7.58 (d, 7=2.4 Hz.lH), 7.54 (m, 2H), 7.38 (m,lH), 7.21 (dd, 7=2.8 and 8.8 Hz, IH), 7.02 (d, 7=8.4 Hz, IH), 6.85 (d,7=2.8Hz,lH). (Figure Remove) [0491] In the same manner as that described in Example 246 compounds 249A and 249B were prepared from 249-S1. For 249A: 'H NMR (400 MHz, CDC13): 8 7.73 (d, .7=1.6 Hz,lH), 7.33 (dd, .7-2.8 and 8.8 Hz, IH), 7.21 (d, 7=2.8 Hz,lH), 6.95 (d, 7=8.4 Hz.lH), 6.43 (d, y=2.0Hz,lH), 5.64 («,1H), 4.70 (m, 2H). For 249B: 'H NMR (400 MHz, CDC13): 8 10.38 (s,lH), 7.59 (d, J=2.8H:/, IH), 7.52 (d, 7=2.8 Hz,lH), 7.17 (dd, 7=2.8 and 8.8 Hz, IH), 6.98 (d,7=8.4 Hz,IH), 6.73 (d, J=2.4Hz,lH), 4.78 (m, 2H). (Figure Remove) [0492] In the same manner as that described in Example 246 compounds 250A and 250B were prepared from 250-S1. For 250A: !H NMR (400 MHz, CDC13): 6 7.62 (d, 7=1 .6 Hz.lH), 7.46 (dd, .7=2.8 and 8.8 Hz, IH), 7.37 (d, .7=2.8 Hz.lH), 6.94 (d, .7=8.8 Hz.lH), 6.32 (d, 7=1 .6 Hz,lH), 4.09 (q, 7=7.2 Hz, 2H), 1.39 (t, .7=7.2 Hz,3H). For 250B: ]H NMR (400 MHz, CDC13): 6 10.95 (s,lH), 7.65 (d, 7=2.0Hz,lH), 7.44 (d, .7=2.4 Hz,lH), 7.27 (dd, 7=2.8 and 9.2 Hz, IH), 6.91 (d, 7=9.2 Hz.lH), 6.58 (d, 7=2.4Hz,lH), 4.22 (q, 7=7.2 Hz,2H), 1.54 (t, 7=7.2 Hz,3H).(Figure Remove) [0493] In the same manner as that described in Example 246 compounds 251A and 251B were prepared from 251-S1. For 251 A: !H NMR (400 MHz, CDC13): 8 7.64 (d, 7=2.0 Hz,lH), 7.32 (dd, 7=2.8 and 8.8 Hz, IH), 7.17 (d, 7=2.8 Hz.lH), 6.98 (d, 7=8.8Hz,lH), 6.33 (d, 7=2.0 Hz.lH), 4.05 (m, 2H), 1.75 (m, 2H), 1.22 (m, 2H), 0.85 (t, 7=7.2 Hz,3H). For 251B: 'H NMR (400 MHz, CDC13): 5 10.92 (s,lH), 7.51 (d, 7=2.8Hz,lH), 7.42 (d, 7=2.8 Hz,lH), 7.13 (dd, 7=2.8 and 8.8 Hz, IH), 6.95 (d, 7=8.8 Hz.lH), 6.58 (d, 7=2.8Hz,lH), 4.17 (m, 2H), 1.88 (m, 2H), 1.39 (m, 2H), 0.98 (t, 7=7.2 Hz, 3H). (Figure Remove) [0494] A solution of 252-S1 (0.76 g, 2.76 mmol), ethylhydrazine oxalate (0.414 g, 2.76 mmol) and EtjN (0.96 ml, 6.9 mmol) in EtOH (10 mL) was refluxed overnight. The mixture was concentrated, dissolved in EtOAc, washed with 1 N HC1 and brine, dried and concentrated. Purification via flash column (hexane/EtOAc 10:1) gave 252A (0.28 g) and 252B (0.23 g) as white solids, respectively. For 252A: 'H NMR (400 MHz, CDC13): 6 7.80 (m, 2H), 7.35-7.22 (m, 5H), 7.02 (d, J=2.8 Hz,lH), 6.57 (s,lH), 5.90 (s,lH), 4.10 (q, J=7.2 Hz,2H), 1 .41 (t, J=7.2 Hz,3H). For 252B: 'H NMR (400 MHz, CDC13): 6 1 1.05 (s,lH), 7.55 (m,6H), 7.20 (d, J=2.8 Hz,lH), 6.97 (d, J=2.8Hz, 1H), 6.64 (s,lH), 4.22 (q, J=7.2 Hz,2H), 1.50(t, J=7.2Hz,3H). (Figure Remove) [0495] A mixture of 253-81(5.116 g, 26.29 mmol), TBSC1 (4.36 g, 28.92 mmol) and imidazole (2.68 g, 39.44 mmol) in DMF (100 mL) was stirred at room temperature overnight. The mixture was diluted with EtOAc, washed with brine, dried and concentrated. Purification via flash column (hexane/EtOAc 10:1) gave 253-S2 as colorless oil (7.8 g). !H NMR (400 MHz, CDC13): 6 7.61 (m,2H), 7.15 (m,lH), 6.88 (d, J=9.2Hz,lH), 6.60 (m,lH), 0.98 (s,9H), 0.22 (s,3H), 0.21 (s,3H). [0496] To a solution of 253-S2 (0.6 g, 1.94 mmol) in THF (10 mL) was added NaHMDS (1.0 M in THF, 2.14 mL, 2.14 mmol) at 0 °C. After 5 min. at 0 °C, BnBr (242 uL, 2.04 mmol) was added. The mixture was warmed to room temperature, and kept at this temperature for 2 h. The reaction was quenched with brine, extracted with EtOAc, washed with brine, dried and concentrated. Purification via flash column (hexane/EtOAc 30:1) gave 253-S3 as colorless oil (0.4 g). 1H NMR (400 MHz, CDC13): 6 7.81 (m.lH), 7.36-7.22 (m,6H), 7.14 (m,lH), 6.81 (m,lH), 6.71 (m,lH), 5.37 (s,2H), 0.92 (s,9H), 0.13 (s,3H), 0.01(s,3H). [0497] To a solution of 253-S3 (0.4 g, 1.0 mmol) in THF (5 mL) was added TBAF (1.0 M in THF, 1.5 mL, 1.5 mmol) at 0 °C. The mixture was warmed to room temperature, and kept at this temperature for 0.5 h. The reaction was quenched with brine, extracted with EtOAc, washed with brine, dried and concentrated to give 253 as a white solid (0.28 g). 'H NMR (400 MHz, CDCb): 5 7.51 (m,lH), 7.44 (m,lH), 7.40-7.33 (m,3H), 7.24 (m,2H), 7.15 (m,lH), 6.93 (m,lH), 6.62 (m,lH), 5.34 (s,2H). (Figure Remove) [0498] A mixture of 4-bromopyrazole 254-S1 (0.47 g, 3.20 mmol), iodoethane (2.5 g, 16,0 mmol) and K2CO3 (0.88 g,6.4 mmol) in DMF (5 mL) was heated at 80 °C overnight. The mixture was diluted with ether, washed with brine, dried and concentrated. Purification via flash column (hexane/EtOAc 10:1) gave 254-S2 as colorless oil (0.45 g). 'H NMR (400 MHz, CDC13): 8 7.45 (s,lH), 7.41 (s,!H), 4.18 (q,2H), 1.45 (t,3H). [0499] To a solution of 254-S2 (0.45 g, 2.57mmol) in Et2O (5 mL) was added n-BuLi (2.5 M in hexanes, 1.13 ml, 2.83 mmol) at - 78°C. After 20 min at - 78DC, Bu3SnCl (852 nL, 2.83 mmol) was added drop wise. The reaction mixture was slowly warmed to room temperature over 5 h, then, quenched with, saturated aqueous NH4C1 solution, extracted with EtaO. The organic layer was washed with brine, dried and concentrated to give 254-S3 as a crude product, which was used for next reaction without further purification. [0500] A mixture of 2-bromo-4-Cl-phenol 254-S4 (8,57 g, 41.31 mmol), MOMC1 (3.99 g, 49.57 mmol) and K2CO3 (11.4 g, 82.62 mmol) in DMF (60 mL) was stirred overnight. The mixture was quenched with saturated aqueous NaHCO3 solution, extracted with ethyl ether. The organic layer was washed with brine, dried and concentrated. Purification via flash column (hexane/EtOAc 20:1) gave 254-S5 as colorless oil (10.0 g). [0501] A mixture of 254-S3 (ca.1.8 mmol), 254-S5 (407 mg, 1.62 mmol) and Pd(PPh3)4 (104 mg, 0.09 mmol) in xylene (4 mL) was heated at 140 °C under nitrogen for 3 h. The mixture was concentrated, and the residue was purified by flash column (hexane/EtOAc 8:1) to give 254-S6 as colorless oil (249 mg). 'H NMR (400 MHz, CDC13): 6 7.88 (s,lH), 7.84 (s,lH), 7.47 (m.lH), 7.11 (m,2H), 5.24 (s,2H), 4.22 (q,2H), 3.50 (s,3H), 1.53 (t,3H). [0502] A mixture of 254-86(249 mg), IN HC1 aqueous solution (5 mL), THF (5 mL) and MeOH (3 mL) was heated at 100 °C for 3 h. The mixture was concentrated, extracted with ether, washed with brine, dried, and concentrated to give 254 as a pale yellow solid (208 mg). 'H NMR (400 MHz, CDC13): 6 7.81 (s,lH), 7.80 (s,lH), 7.36 (d, 1H), 7.18 (dd, 1H), 6.84 (d,lH),4.23 (q,2H), 1.56(t,3H). (Figure Remove) [0503] In the same manner as that described in Example 28 compound 255 was prepared from 255-S1 and 255-S2. 'H NMR (400 MHz, DMSO-d6): 5 7.91 (d, J=2.8 Hz, 1H), 7.78 (d, J=2.0 Hz, 1H), 7.54 (m, 2H), 7.47 (m,2H), 7.21 (dd, J=2.4 and 8.8 Hz, 1H), 7.09 (d,J=2.0Hz,lH), 6.98 (d, J=8.8Hz,lH), 6.09 (s,lH), 4.18 (m,2H), 1.42 (t, J=7.6Hz, 3H). (Figure Remove) [0504] In the same manner as that described in Example 28 compound 256 was prepared from 256-S1 and 256-S2. ]H NMR (400 MHz, DMSO-d6): 6 7.77 (d, J=1.6Hz,lH), 7.38 ;m,3H), 7.26 (m,3H), 7.21 (d, J=2.4 Hz, IH), 7.16 (m, 5H), 6.95 (d, J=9.6 Hz, IH), 6.62 (d, I=2,OHz, IH), 5.75 (s, IH). (Figure Remove) [0505] In the same manner as that described in Example 28 compound 257 was prepared from 257-S1 and 257-S2. 'H NMR (400 MHz, DMSO-d6): 6 7.48 (m,2H), 7.43 (m,2H), 7.33 (m,3H), 7.08 (d, J-9.6 Hz, IH), 6.27 (d, J=2.0 Hz, IH), 5.96 (s, IH), 4.02 (m,2H), 1.15 (t, J=7.2Hz,3H). (Figure Remove) [0506] In the same manner as that descnbed in Example 28 compound 258 was prepared from 258-S1 and 258-S2. !H NMR (400 MHz, DMSO-d6): 5 7.91 (d, J=2.8Hz,lH), 7.78 (d,J=2.4 Hz.lH), 7.53 (m,2H), 7.36 (m,3H), 7.22 (dd, J=2.8 and 9.2 Hz,lH), 7.11 (d, J=2.4 Hz, IH), 7.0 (d, J=9.2 Hz, IH), 6.04(s, IH), 4.18 (m,2H), 1.40 (t, J=7.6 Hz, 3H). (Figure Remove) [0507] In the same manner as that described in Example 28 compound 259 was prepared from 259-S1 and 259-S2. 'H NMR (400 MHz, DMSO-d6): 8 7.89 (m,2H), 7.80 (m,2H), 7.74 (ra,lH), 7.65 (m.lH), 7.25 (dd, J=2.8 and 9.2 Hz,lH), 7.05 (m, 2H), 6.25 (s, IH), 4.19 (m,2H), 1.40 (t, J=7.6 Hz, 3H). (Figure Remove) [0508] In the same manner as that described in Example 28 compound 260 was prepared from 260-S1 and 260-S2. 'H NMR (400 MHz, DMSO-d6): 8 7.48 (m,2H), 7.33 (m,7H), 7.09 (d,J=9.6 Hz,lH), 6.27 (d, J=2.0 Hz, IH), 5.91(s, IH), 4.05 (m,2H), 1.16 (t, J-7.6 Hz, 3H). [0509] In the same manner as that described in Example 28 compound 261 was prepared from 261-S1 and 261-S2. !H NMR (400 MHz, DMSO-d6): 8 7.91 (d,J=2.8 Hz, IH), 7.59-7.20 (m,12H), 6.98 (d,J=9.2Hz,lH), 5.96 (s.lH), 4.20 (m,2H), 1.32 (t, J=7.2 Hz, 3H). (Figure Remove) (0510] In the same manner as that described in Example 28 compound 262 was prepared from 262-S1 and 262-S2. 'H NMR (400 MHz, DMSO-d6): 8 7.83 (m, 2H), 7.54 (dd, J=2.8 and 8.8 Hz,lH), 7.44-7.29 (m,9H), 7.13 (d, J=9.2 Hz, IH), 6.77(s, IH), 5.96 (s,lH), 4.08 (m,2H), 1.24(t,J=7.2Hz, 3H). (Figure Remove) (0511] In the same manner as that described in Example 28 compound 263 was prepared from 263-S1 and 263-S2. !H NMR (400 MHz, DMSO-d6): 6 7.69 (m,2H), 7.56 (m,2H), 7.42 (m,3H), 7.18 (m,lH), 6.84 (d, J=2.8 Hz, IH), 6.76 (d, J=8.8 Hz, IH), 5.68 (s, IH), 4.86 (m,2H). (Figure Remove) [0512] In the same manner as that described in Example 28 compound 264 was prepared from 264-S1 and 264-S2. 'H NMR (400 MHz, DMSO-d6): 5 8.58 (d, J=2.8Hz,lH), 8.06 (d, J=3.2 Hz,lH), 7.92 (m,2H), 7.56-7.45 (m,5H), 7.40 (d, J=2.8Hz,lH), 7.33 (m,2H), 7.06 (d,J=8.8Hz, 1H), 6.14(s, (Figure Remove) (0514) In the same manner as that described in Example 28 compound 266 was prepared from 266-S1 and 266-S2. 'H NMR (400 MHz, DMSO-d6): 8 7.89 (d, J=2.4Hz,lH), 7.74 (d,J=2.0 Hz,lH), 7.53 (m,2H), 7.45 (m,2H), 7.22 (dd, J=2.8 and 8.8 Hz,lH), 7.11 (d, J=2.0 Hz, 1H), 7.0 (d, J=9.2 Hz, 1H), 6.09(s, 1H), 3.95 (s,3H). (Figure Remove) [0515] In the same manner as that described in Example 28 compound 267 was prepared from 267-S1 and 267-S2. 'H NMR (400 MHz, DMSO-d6): 5 7.90 (d, J~2.8Hz.lH), 7.81 (d,J=2.0 Hz,lH), 7.58 (m.lH), 7.46-7.41 (m,3H), 7.24 (dd, J=2.8 and 9.2 Hz,lH), 7.10 (d, J=2.4 Hz, IH), 6.99 (d, J=8.8 Hz, IH), 6.1 l(s, IH), 4.21 (m,2H), 1.40 (t, J=7.6Hz, 3H). (Figure Remove) [0516] In the same manner as that described in Example 28 compound 268 was prepared from 268-S1 and 268-S2. !H NMR (400 MHz, DMSO-d6): 6 7.90 (d, J=2.8Hz,IH), 7.81 (d,J=2.0 Hz,lH), 7.73 (m,lH), 7.56 (m,lH), 7.49 (m,lH), 7.37 (m,lH), 7.24 (dd, J=2.4 and 8.8 Hz,lH), 7.09 (d, J=2.4 Hz, IH), 7.02 (d, J=8.8 Hz, IH), 6.10(s, IH), 4.19 (m,2H), 1.40 (t, J=7.6 Hz, 3H). (Figure Remove) [0517] In the same manner as that described in Example 28 compound 269 was prepared from 269-S1 and 269-S2. 'H NMR (400 MHz, DMSO-d6): 8 7.90 (s,!H), 7.88 (d, J=2.8Hz,lH), 7.82 (s.lH), 7.79 (d,J-2.4 Hz,lH), 7.74 (m.lH), 7.65 (m,lH), 7.24 (dd, J=2.8 and 8.8 Hz.lH), 7.05 (rn,2H), 6.25 (s, IH), 4.14 (m,2H), 1.78 (m,2H), 1.25 (m,2H), 0.88 (m,3H). (Figure Remove) 0518] In the same manner as that described in Example 28 compound 270 was prepared from 270-S1 and 270-S2. 'H NMR (400 MHz, DMSO-d6): 8 7.91 (d, J=2.8Hz,lH), 7.78 (d,J=2.4 Hz.lH), 7.53 (m,2H), 7.39 (m,3H), 7.22 (dd, J=2.4 and 8.8 Hz,lH), 7.12 (d, J=2.4 Hz, IH), 7.01 (d, J=8.8 Hz, IH), 6.03 (s, IH), 4.15 (t, J=7.2Hz,2H), 1.78 (m,2H), 1.27 (m,2H), 0.90 (t, J=7.6 Hz, 3H). (Figure Remove) [0519] In the same mariner as that described in Example 28 compound 271 was prepared from 271-S1 and 271-S2, 'H NMR (400 MHz, DMSO-d6): 8 7.91 (d, J=2.4Hz,lH), 7.78 (d,J=1.6 Hz,lH), 7.54 (m,4H), 7.23 (dd, J=2.8 and 9.2 Hz.lH), 7.o9 (d, J=2.0 Hz, IH), 7.0 (d, J=9.2Hz,lH), 6.09 (s.lH), 4.14 (m,2H), 1.78 (m,2H), 1.27 (m,2H), 0.90 (t, J=6.8 Hz, 3H). (Figure Remove) [0520] In the same mariner as that described in Example 28 compound 272 was prepared from 272-S1 and 272-S2. 'H NMR (400 MHz, DMSO-d6): 8 7.90 (m,2H), 7.53 (m,2H), 7.39-7.33 (m,5H), 7.30 (m,3H), 7.22 (dd, J=2.8 and 9.2 Hz.lH), 7.18 (d, J=2.4 Hz, IH), 7.02 (d, J=8.8 Hz, IH), 6.04(s, IH), 5.38 (s,2H). (Figure Remove) 521 j In the same manner as that described in Example 28 compound 273 was prepared from 273-S1 and 273-S2. ]H NMR (400 MHz, DMSO-d6): 5 8.04 (d, J=2.8Hz,lH), 7.78 (d,J=2.4 Hz,lH), 7.53 (m,2H), 7.47 (m,2H), 7.33 (dd, 3=2.8 and 8.8 Hz,lH), 7.09 (d, J=2.0 Hz, IH), 6.95 (d, J=8.8 Hz, IH), 6.09 (s, IH), 4.19 (t, J=7.6Hz,2H), 1.40 (t, J=7.6 Hz, 3H). (Figure Remove) [0522] In the same manner as that described in Example 28 compound 274 was prepared from 274-S1 and 274-S2. 'H NMR (400 MHz, DM$O-d6): 8 8.04 (d, J=2.4Hz,lH), 7.79 (d,J=2.4 Hz,lH), 7.53 (m,2H), 7.41-7.32 (m,4H), 7.11 (d,J=2.0Hz,lH), 6.97 (d, J=8.8 Hz, IH), 6.04(s, IH), 4.19 (m,2H), 1.42 (t, J=7.6 Hz, 3H). (Figure Remove) [0523] In the same manner as that described in Example 28 compound 275 was prepared from 275-S1 and 275-S2. !H NMR (400 MHz, DMSO-d6): 8 8.02 (d, J=2.4Hz,lH), 7.89 (s,!H), 7.80 (m,2H), 7.73 (m.lH), 7.64 (m,lH), 7.37 (dd, J=2.8 and 8.8 Hz,lH), 7.04 (d, J=2.4 Hz, IH), 6.98 (d, J=8.8 Hz, IH), 6.24(s, IH), 4.19 (m,2H), 1.40 (t, J=7.6 Hz, 3H). (Figure Remove) from 276-S1 and 276-S2. *H NMR (400 MHz, DMSO-d6): 8 7.88 (d, J=2.4Hz,lH), 7.80 (d.J-2.4 Hz,lH), 7.56 (m,2H), 7.41-7.32 (m,3H), 7.10 (dd, J=2.8 and 9.2 Hz.lH), 7.00 (d, J=2.0 Hz, IH), 6.53 (d, J=8.8 Hz, IH), 4.20 (m,2H), 1.88 (s,3H), 1.41 (t, J=6.8 Hz, 3H). (Figure Remove) [0525] In the same manner as that described in Example 42 compound 277 was prepared from 277-S1 and 277-S2. 'H NMR (400 MHz, CDCl3): 6 7.72 (d, J=2.8Hz,lH), 7.70 (d,J=2.4 Hz,lH), 7.52 (m,lH), 7.41-7.39 (m.lH), 7.37-7.34 (m,2H), 7.08 (dd, J=2.4 and 9.2 Hz,lH), 6.84 (d, J=2.8 Hz, IH), 6.41 (d, J=9.2 Hz, IH), 4.46 (q, J=7.2 Hz,2H), 2.04 (s,3H), 1.61 (t, J=7.6 Hz, 3H). (Figure Remove) [0526] In the same manner as that described in Example 28 compound 278 was prepared from 278-S1 and 278-S2. 'H NMR (400 MHz, DMSO-d6): 6 8.44 (s,lH), 8.11 (s,lH), 7.88 (s,lli), 7.80 (d, J=8Hz,lH), 7.73 (d,J=7.6Hz,lH), 7.68 (d,J=2.8Hz,lH), 7.66 (m,lH), 7.14 (dd, J=2.8 and 8.8 Hz,lH), 6.98 (d, J=9.2 Hz, IH), 6.24 (s.lH), 4.14 (q, J=7.6Hz,2H), 1.37 (t, J=7.6 Hz, 3H). (Figure Remove) [0527] In the same manner as that described in Example 28 compound 279 was prepared from 279-S1 and 279-S2. 'H NMR (400 MHz, DMSO-d6): 5 8.49 (s,lH), 8.12 (s,lH), 7.67 (d,J=2.4 Hz.lH), 7.51 (m,2H), 7.40-7.34 (m,3H), 7.09(dd, J=2.4 and 8.4 Hz,lH), 6.93 (d, J=8.8 Hz, IH), 6.01 (s,lH), 4.14 (q, J=7.6Hz,2H), 1.39 (t, J=7.6 Hz, 3H). (Figure Remove) [0528] In the same manner as that described in Example 28 compound 280 was prepared from 280-S1 and 280-S2. 'H NMR (400 MHz, CDC13): 6 7.50-7.42 (m,6H), 7.19 (dd, J=2.8 and 8.8 Hz.lH), 6.97 (d, J=8.8 Hz, IH), 6.65 (d, J=2.0Hz, IH), 6.21 (s.lH).(Figure Remove) [0529] The two enantiomers were separated by chiral HPLC using a 25 cm x 21.1 mm Regis Technologies (R,R) WHELK-0 2 10/100 column at ambient temperature. HPLC methods and conditions: 50% iPrOH-50% Hexanes-0.1% TFA, 30 niL/min., AX220 nm. One enantiomer: RT 6.85 min. The other enantiomer: RT 9.6 min. (Figure Remove) [0530] The two enantiomers were separated by chiral HPLC using a 25 cm x 21.1 mm Regis Technologies (R,R) WHELK-0 2 10/100 column at ambient temperature. HPLC methods and conditions: 50% iPrOH-50% Hexanes-0.1% TFA, 50 niL/min., 1=220 nm. One enantiomer: RT 6,70 min. The other enantiomer: RT 8.5 min. (Figure Remove) [0531] The two enantiomers were separated by chiral HPLC using a 25 cm x 21.1 mm Regis Technologies (R,R) WHELK-0 2 10/100 column at ambient temperature. HPLC methods and conditions: 50% iPrOH-50%, Hexanes-0.1% TFA, 30 mL/min., X=220 nm. One enantiomer: RT 6.19 min. The other enantiomer: RT 8.20 min. (Figure Remove) |0532] The two enantiomers were separated by chiral HPLC using a 25 cm x 21.1 mm Regis Technologies (R,R) WHELK-O 2 10/100 column at ambient temperature. HPLC methods and conditions: 40% iPrOH-60% Hexanes-0.1% TFA, 30 mL/min., A=220 nm. One enantiomer: RT 7.15 min. The other enantiomer: RT 10.0 min. (Figure Remove) [0533] The two enantiomers were separated by chiral HPLC using a 25 cm x 21.1 mm Regis Technologies (R,R) WHELK-O 2 10/100 column at ambient temperature. HPLC methods and condition: 40% iPrOH-60% Hexanes-0.1% TFA, 50 mL/min., X=220 nm. One enantiomer: RT 6.0 min. The other enantiomer : RT 8.70 min. (Figure Remove) [0534] The two enanliomers were separated by chiral HPLC using a 25 cm x 21.1 mm Regis Technologies (R,R) WHELK-0 2 10/100 column at ambient temperature. HPLC methods and conditions: 40% iPrOH-60% Hexanes-0.1% TFA, 30 mL/min., X=220 nm. One enantiomer: RT 6.7 min. The other enantiomer: RT 8.30 min. (Figure Remove) [0535] The two enantiomers were separated by chiral HPLC using a 25 cm x 21.1 mm Regis Technologies (R,R) WHELK-O 2 10/100 column at ambient temperature. HPLC methods and conditions: 40% iPrOH-60% Hexanes-0.1% TFA, 40 mL/min., A-220 nm. One enantiomer: RT 11.2 min. The other enantiomer: RT 14.0 min. (Figure Remove) [0536] A mixture of methyl-5-chloro-2-hydroxybenzoate 288 (24.9 g, 0.133 mol) and hydrazine hydrate (11.33 niL,0.20 mol) in toluene was heated overnight at 120 °C in a sealed tube. After cooling to room temperature, the solids were collected by filtration, washed with MeOH and air dried to give a white solid (21.38 g). 'HNMR (400 MHz, DMSO-d6) 8 7.88 (d,J=2.8 Hz,lH), 7.38 (dd, J=2.8 and 8.8Hz,lH), 6.92 (d,J=8.8Hz,lH). |0537] A mixture of the above product (21.38 g) and trimethyl othoformate (150 mL) was heated overnight at 1 10 °C. The reaction mixture was concentrated to remove about 100 mL of trimethyl othoformate. Then, 300 mL of toluene was added, and the mixture was refluxed overnight. The mixture was filtered, and the filtrate was concentrated. The residue was recrystallized from MeOH to give 288 as a pale yellow solid (9.0 g). 'HNMR (400 MHz, DMSO-d6) 5 9.34 (s,lH), 7.76 (d,J=2.8 Hz,lH), 7.47 (dd, J=2.8 and 8.8Hz,lH), 7.08 (d,J=8.4Hz,lH). (Figure Remove) (0538] In the same manner as that described in Example 28 compound 289 was prepared from 289-S1 and 289-S2. 'HNMR (400 MHz, DMSO-d6) 5 9.43 (s,lH), 7.94 (d, J=2.8 HzJH), 7.71 (d,J=2.8Hz,lH), 7.68 (m,2H), 7.52 (m,2H), 7.25 (d,J=9.2Hz,lH), 6.21 (s,lH). (Figure Remove) [0539] In the same manner as that described in Example 28 compound 290 was prepared from 290-S1 and 290-S2. !HNMR (400 MHz, DMSO-d6) 8 9.45 (s.lH), 7.92 (d,J=2.4 Hz,lH), 7.70 (dd, J=2.8 and 9.2 Hz.lH), 7.65 (m,2H), 7.39 (m,3H), 7.26 (d,J=8.8Hz,lH), 6.15 (s,lH). (Figure Remove) [0540] A mixture of 2 amino-4-chlorophenol (5.69 g, 39.63 mmol) and 2,5-dimethoxy-tetrafuran (5.24 g, 39.63 mmol) in AcOH/H2O (9:1, 200 mL) was heated for 30 min. at 110 "C under nitrogen. The mixture was concentrated, extracted with EtOAc, washed with saturated aqueous NaHCOj, dried and concentrated. Purification via flash column (0-5% EtOAc in hexanes) gave 291 as a red oil (6.37 g, 83%). 'HNMR (400 MHz, CDC13) 5 7.25 (m, 2H), 6.97 (d, J=8.8 Hz.lH), 6.85 (m,2H), 6.41 (m,2H), 5.26 (s.lH). (Figure Remove) [0541 ] In the same manner as that described in Example 28 compound 292 was prepared from 292-S1 and 292-S2. 'HNMR (400 MHz, CDC13) 6 7.42 (m,2H), 7.36 (m,3H), 7.33 (d, J=2.4 Hz,lH), 7.15 (dd, J=2.8 and 8.8 Hz,lH), 7.06 (m, 2H), 6.90 (d,J=8.4Hz,!H), 6.35 (m, 2H), 5.44 (s, 1H). (Figure Remove) [0542] In the same manner as that described in Example 28 compound 293 was prepared from 293-S1 and 293-S2. !HNMR (400 MHz, CDC13) 6 7.69 (s.lH), 7.62 (m,2H), 7.48 (m,lH), 7.35 (d, J=2.4 Hz,lH), 7.18 (dd, J-2.8 and 8.8 Hz.lH), 7.01 (m, 2H), 6.92 (d,J=8.4Hz,lH), 6.34 (m, 2H), 5.46 (s, 1H). (Figure Remove) [0543] A mixture of 2-Br-4-Cl-phenol (8.57 g, 41.31 mmol), MOMC1 (3.99 g, 49.57 mmol) and KjCOa (11.4 g, 82.62 mmol) in DMF (60 mL) was stirred overnight. The reaction was quenched with saturated aqueous NaHCOj solution, extracted with ethyl ether. The organic layer was washed with brine, dried and concentrated. Purification via flash column (hexane/EtOAc 20:1) gave 294-S2 as colorless oil (10.0 g). [0544] To a solution of 294-S2 (1.683 g, 6.69 mmol) in THF (20 mL) was added n-BuLi (2.5 M in hexanes, 2.94 mL, 7.36 mmol) at -78 °C. After 20 min. at - 78 °C, trimethyl boronate (1.15 mL, 10.04 mmol) was added drop wise. The mixture was slowly warmed to room temperature over 2 h. After 0.5 h at room temperature, the reaction mixture was quenched with 1 N HC1 aqueous solution, and stirred for 10 min. The mixture was extracted with Et20, washed with brine, dried and concentrated to give pale yellow oil. Crystallization from Et2O/hexane gave 294-S3 as a white solid (1.0 g). 'HNMR (400 MHz, CDC13) 8 7.80 (d,J-2.0 Hz,lH), 7.36 (dd, J=2.4 and 8.8 Hz, 1H), 7.09 (d,J=8.8Hz,lH), 6.0 (br, 2H), 5.27 (s,2H), 3.50 (s,3H). |0545] A mixture of 294-S3 (171 mg, 0.97 mmol), 5-bromopyrimidine (138 rng,0.87 mmol), Pd(OAc)2 and 2M Na2CO3 (0.97 mL,1.58 mmol) in DMF (5mL) was stirred overnight at room temperature under nitrogen. The reaction mixture was quenched with brine, extracted with Et2O, washed with brine, dried and concentrated. Purification via flash column (Hexane/EtOAc 10:1 to 5:1) gave 294-S4 as a white solid (31 mg). 'HNMR (400 MHz, CDC13) 5 9.19 (s,lH), 8.90 (s,2H), 7.36 (dd, J=2.4 and 8.8 Hz, 1H), 7.32 (d,J=2.4Hz,lH), 7.22 (d,J=8.8 Hz.lH), 5.19 (s,2H), 3.42 (s,3H). |0546| A mixture of 294-S4 (31 mg), MeOH (5 mL) and 1 N HC1 (5 mL) was heated at 100 °C for 2 h. The mixture was concentrated, dissolved in EtOAc, washed with brine, dried and concentrated to give 294-S5 as a white solid (18 mg). 'HNMR (400 MHz, CDC13) 5 9.21 (s,lH), 8.97 (s,2H), 7.32-7.,25 (m,2H), 6.88 (d,J=8.8 Hz,lH). |0547] 294 was prepared from 294-S5 and 294-S6 in the same manner as that described in Example 28. 'HNMR (400 MHz, DMSO-d6) 5 9.16 (s.lH), 9.07 (s, 2H), 7.61 (d,J=2.8Hz,lH), 7.49 (dd, J-2.8 and 8.4 Hz,lH), 7.48-7.39 (m, 5H), 7.18 (d,J=8.8Hz,lH), 6.10 (s, 1H). (Figure Remove) [0548] A mixture of 295-S1 (500 mg) and benzylamine (3 mL) was heated overnight at 150 °C in a sealed tube under nitrogen. The mixture was diluted with EtOAc, washed with 2 N HCI and brine, dried and concentrated. Purification via flash column (hexane/EtOAc 10:1 to 5:1) gave 295-S2 as a white solid (0.25 g). 'HNMR (400 MHz, DMSO-d6) 5 12.50 (s,lH), 9.37 (m,lH), 7.96(d,J=2.4Hz,lH), 7.44 (dd, J=2.4 and 8.8 Hz,lH), 7.30 (m,4H), 7.22 (m,lH), 6.92 (d,J=9.2Hz,lH), 4.49 (d,J=6 Hz,2H). [0549] 295 was prepared from 295-S2 and 295-S3 in the same manner as that described in Example 28. 'HNMR (400 MHz, DMSO-d6) 8 7.77 (d,J=2.8Hz,lH), 7.48-7.41 (m, 3H), 7.34-7.23 (m,9H), 7.12 (d,J=8.8Hz,lH), 6.16 (s, 1H), 4.55 (m,2H). (Figure Remove) [0550] To a suspension of 5-chlorosalicyclic acid (2.07 g) in CHaCb (50 mL) was added 2.63 mL SOClj, and refluxed for half an hour. The reaction mixture was concentrated. The residue was dissolved in CHjCk (60 mL), and was charged 3 g of amino ketone followed by 5 mL of triethyl amine at 0 °C. The reaction solution was stirred at room temperature for 2 hours, washed with NaliCOj solution and dried. The solvent was removed to give 296-S3 as amber oil. [0551 ] A mixture of 296-S3 and pTsOH (0.5 g) in toluene (200 mL) was refluxed overnight with a Dean-Stark trap. The solvent was removed, and the residue was dissolved in ethyl acetate. The solution was washed with NaHCO} aqueous solution, dried and concentrated. Purification with chromatography (hexanes/ethyl acetate 5/1) gave 0.35 g of 296-S4 as a white solid. 'H NMR (400 MHz, CDC13): 5 11.06 (s, 1H), 7.87 - 7.01 (m, 8H). (0552] The phenol 296-S4 was reacted with 0.5 g 296-S5 and 800 mg Cs2CO3 in CH3CN (60 mL) overnight. The salt was filtered off, and the filtrate was removed. Purification with chromatography (hexanes/ethyl acetate 5/1) gave the ester product, which was hydrolyzed with LiOH (IN, 30 mL) to give 296 (0.21 g) as a light yellow solid. 'H NMR (400 MHz, DMSO-d6):58.01-7.13(m, 12H),6.14(s, (Figure Remove) [0553] In the same manner as that described in Example 296 compound 297-S3 was prepared from 297-S1. 'H NMR (400 MHz, CDC13): 6 12.17 (s, 1H), 7.34-6.91 (m, 3H), 6.51 (br, 1H), 4.49 (m, 1H), 3.57 (m, 2H), 3.44 (ss, 6H). [0554] A mixture of 297-S2 (1.5 g), 297-83(1.32 g) and Cs2CO3(1.88 g) was stirred for several hours. The salt was filtered out. The solution was concentrated, diluted with ethyl acetate, washed with brine and dried. The solvent was removed, and the residue was treated with 80% AcOH for several hours, concentrated and extracted with ethyl acetate. Purification with chromatography (hexanes/ethyl acetate 5/1) gave the aldehyde compound (2.2 g) as colorless oil. 'H NMR (400 MHz, CDC13): 8 9.73 (s, 1H), 9.29 (br. 1H), 8.19 - 6.66 (m, 8H), 5.75 (s, 1H), 4.36 (d, 2H), 3.76 (s, 3H). ]0555] The solution of aldehyde in toluene with 5 mL AcOH was refluxed overnight, concentrated. Purification with chromatography (hexanes/ethyl acetate 5/1) gave the ester product, The hydrolysis with LiOH (IN, 20 mL) gave 297 (0.13 g) as a white solid. *H NMR (400 MHz, DMSO-d6): 5 8.35 - 7.15 (m, 10H), 6.26 (s, 1H). (Figure Remove) ared from 298-S1 and 298-S2. !H NMR (400 MHz, DMSO): 6 7.86 - 6.86 (m, 9H), 5.95 (s, 1H). (Figure Remove) [0557] A mixture of 299-S1, dichloroacetone in a pressure vessel was stirred for several hours at 120 °C. The resulting solid was dissolved in ethyl acetate. Purification with chromatography (hexanes/ethyl acetate 10/1) gave 299-S2 (6.2 g) as a white solid. [0558] In the same manner as that described in Example 28 compound 299 was prepared from 299-S3 and 299-S2. !H NMR (400 MHz, CDC13): 5 7.94 - 6.72 (m, 9H), 5.62 (s, 1H), 4.60 (s, 2H). (Figure Remove) [0559] 300-S1 (0.26 g) in DMF and 0.5 g NaOMe was stirred for one hour, quenched with HC1 solution (1 N), diluted with water, extracted with ethyl acetate. The solvent was removed, and the residue was purified with chromatography (ethyl acetate) to give the acid product (0.23 g) as white solid. 'H NMR (400 MHz, CDC13): 5 8.00 - 6.50 (m, 9H), 5.62 (s, 1H), 4.54 (s,2H), 3.50 (s,3H). (Figure Remove) |0560] In the same manner as that described in Example 28 compound 301 was prepared from301-Sl and301-S2. 'HNMR (400 MHz.DMSO): 5 13.48 (br, 1H), 8.23 - 7.12 (m, 8H), 6.12 (s, 1H), 4.39 (s, 2H), 3.25 (s, 3H). (Figure Remove) [05611 In the same manner as that described in Example 28 compound 302 was prepared from 302-S1 and 302-S2. 'H NMR (400 MHz, DMSO): 8 8.17 - 7.16 (m, 8H), 6.29 (s, lH),4.39(s,2H),3.45(s,3H). (Figure Remove) [0562] A mixture of 303-S1, dichloroacetone in 1-butanol was refluxed overnight. The solution was concentrated, and purified with chromatography (hexanes/ethyl acetate 5:1) to give 303-S2 (7.0 g) as colorless oil. *H NMR (400 MHz, CDC13): 5 11.02 (s, 1H), 7.80-7.01 (m, 4H), 4.50 (s, 2H), 3.58 (t, 211), 1.57 (m, 2H), 1.40 (m, 2H), 0.95 (t, 3H). [0563] In the same manner as that described in Example 28 compound 303 was prepared from 303-S2 and 303-S3. 1H NMR (400 MHz, DMSO): 8 8.17 - 7.02 (m, 8H), 5.32 (s, 1H), 4.42 (s, 2H), 3.58 (m, 2H), 2.47 (m, 2H), 1.72 (m, 2H), 1.32 (m, 2H), 0.85 (t, 3H). (Figure Remove) [0564] To a suspension of NaH (2.09 g, 60%) in DMP was added isopropanol (4 mL) drop wise at 0 °C. The mixture was stirred for half an hour, and then a solution of 304-S1 (6 g) in DMF was added. The solution was stirred for several hours, diluted with ethyl acetate, washed with brine. The solvent was removed, the residue was purified with chromatography (hexanes/ethyl acetate 10:1) to give 304 (2.9 g) as a light yellow oil. *H NMR (400 MHz, CDClj):5 11.07(s, 1H), 7.79-6.99 (m,4H), 4.51 (s, 2H), 3.78 (m, 1H), 1.24(m,6H). (Figure Remove) [0565] In the same manner as that described in Example 28 compound 305 was prepared from 305-S1 and 305-S2. 'H NMR (400 MHz, DMSO): 5 8.18 - 7.12 (m, 8H), 6.11 (s, 1H), 4.42 (s, 2H), 3.71 (m, 1H), 1.14 (d, 6H). (Figure Remove) (0566] In the same manner as that described in Example 28 compound 306 was prepared from 306-S1 and 306-S2. 'H NMR (400 MHz, DMSO): 8 8.15 - 7.13 (m, 8H), 6.15 (s, lH),4.45(s,2H),3.71 (m, 1H), 1.13 (d, 6H). (Figure Remove) [0567] Ln the same manner as that described in Example 28 compound 307 was prepared from 307-S1 and 307-S2. !H NMR (400 MHz, CDC13): 5 7.98 - 6.66 (m, 8H), 5.64 (s, 1H), 4.57 (s, 2H), 3.81 (m, 1H), 1.26 (d, 6H). (Figure Remove) [0568] In the same manner as that described in Example 28 compound 308 was prepared from 308-S1 and 308-S2. 'H NMR (400 MHz, CDClj): 5 7.96 - 6.70 (m, 9H), 5.61 (s, 1H), 4.57 (s, 2H), 3.81 (m, 1H), 1.27 (d, 6H). (Figure Remove) 10569] In the same manner as that described in Example 304 compound 309 was prepared from 309-S1. 'H NMR (400 MHz, CDC13): 5 11.03 (s, 1H), 7.79 - 6.99 (m, 4H), 4.50 (s, 2H), 3.64 (q, 2H), 1.25(t,3H). (Figure Remove) [0570] In the same manner as that described in Example 28 compound 310 was prepared from 310-S1 and 310-S2. 'H NMR (400 MHz, DMSO): 8 13.37 (br, 1H), 8.21 - 7.14 (m, 9 H), 6.07 (s, 1H), 4.41 (s, 2H), 3.54 (q, 2H), 1.13 (t, 3H). (Figure Remove) [0571] In the same manner as that described in Example 28 compound 311 was prepared from 311-S1 and 311-S2. ]H NMR (400 MHz, CDC13): 6 7.96 - 6.69 (m, 8H), 5.57 (s, 1H), 4.56 (s, 2H), 3.68 (q, 2H), 1.27 (t, 3H). (Figure Remove) [0572] In the same manner as that described in Example 28 compound 312 was prepared from 312-S1 and 312-S2. '« NMR (400 MHz, CDC13): 5 7.97 - 6.69 (m, 8H), 5.56 (s, 1H), 4.57 (s, 2H), 3.68 (q, 2H), 1.28 (t, 3H). (Figure Remove) [0573] In the same manner as that described in Example 28 compound 313 was prepared from 313-S1 and 313-S2. !H NMR (400 MHz, DMSO): 5 8.15 - 7.16 (m, 8H), 6.29 (s, 1H), 4.42 (s, 2H), 3.53(q, 2H), 1.12 (t, 3H). (Figure Remove) |0574| In the same manner as that described in Example 28 compound 314 was prepared from 314-S1 and 314-S2. ]H NMR (400 MHz, CDC13): 6 7.96 - 6.71 (m, 9H), 5.61 (s, 1H), 4.57 (s, 2H), 3.61 (t, 2H), 1.63 (m, 2H), 1.39 (m, 2H), 0.95 (t, 3H). (Figure Remove) [0575] In the same manner as that described in Example 28 compound 315 was prepared from 315-S1 and 315-S2. 'H NMR (400 MHz, CDC13): 5 7.97 - 6.69 (m, 8H), 5.55 (s, 1H), 4.56 (s, 2H), 3.60 (t, 2H), 1.63 (m, 2H), 1.39 (m, 2H), 0.93 (t, 3H). (Figure Remove) [0576] A mixture of acid 316-S1 (5 g), chloroacetone (2.3 mL) in DMF with K2CO3 (3.32 g) was stirred for several hours, diluted with ethyl acetate, washed with brine and dried. The solvent was removed, and the residue was dissolved in toluene. The solution was refluxed with NH^Ac (4.6 g), AcOH (50 mL) overnight. The solvent was removed. Purification with chrornatography (hexanes/ethyl acetate 10:1) gave 316-S2 (0.45 g) as colorless oil. *H NMR (400 MHz, CDCb): 5 8.35 - 7.26 (m, 4H), 2.28 (s, 3H). [0577] To a suspension of NaH (0.13 g) in DMF (20 mL) was added drop wise a solution of 316-S3 (0.48 g) in DMF (20 mL) at 0 °C. The mixture was stirred for half an hour, and was added the 316-S2 (0.43 g) in DMF (10 mL) solution. The solution was stirred for one hour, quenched with water, extracted with ethyl acetate, concentrated. Purification with chromatography (ethyl acetate) gave the acid (0.13 g) as a white solid. ]H NMR (400 MHz, CDC13): 5 8.28 - 6.92 (m, 9H), 5.73 (s, 1H), 2.37 (s, 3H). (Figure Remove) [0578] A mixture of 317-S1 (6.0 g), chloroacelone (10 mL) in a pressure vessel was stirred at 120 °C for several hours. The mixture turned to dark mud, which was dissolved in ethyl acetate. The solid left was filtered off. The solution was concentrated, and purified with chromatography (hexanes/ethyl acetate 20:3) to give 317-S2. [0579] 317-S2 was reacted with 1.5 g of 317-S3 and 1 g of Cs2C03 in CH3CN. The mixture was stirred for two hours. The solid was filtered off. The solution was concentrated and purified with chromatography (hexane/ethyl acetate 5:1) to give the ester. Hydrolysis with 1 N LiOH (20 mL) gave 317 (0.25 g) as a light yellow solid. !H NMR (400 MHz, CDC13): 5 7.95 - 6.72 (m, 9H), 5.61 (s, 1H), 2.33 (s, 3H). (Figure Remove) [0580] In the same manner as that described in Example 28 compound 318 was prepared from 318-S1 and 318-S2. 'H NMR (400 MHz, CDC13): 8 8.01 -7.26 (m, 11H), 6.1 l(s, 1H). (Figure Remove) [0581| A solution of 318 (0.73 g), Bu3SnN3 (0.7 mL) in THF was refluxed overnight, then concentrated, and treated with IN HCI. The solution was extracted with ethyl acetate, dried and concentrated. Purification with chromatography (ethyl acetate) gave 319 (0.43 g) as a white solid. 'H NMR (400 MHz, DMSO): 5 8.37-7.42 (m, 12H). (Figure Remove) [0582] A mixture of 320-S1 (5.0 g), chlorobutanone (20 mL) in a pressure vessel was stirred at 120 °C for several hours. The mixture turned to dark mud, which was dissolved in ethyl acetate. The solid left was filtered off. The solution was concentrated, and purified with chromatography (hexanes/ethyl acetate 20:3) to give 320-S2 (0.19 g) as white solid. *H NMR (400 MHz, CDCI3): 5 11.36 (s, 1H), 7.73 - 6.96 (m, 3H), 2.33 (s, 3H), 2.15 (s, 3H). [0583] In the same manner as that described in Example 28 compound 320 was prepared from 320-S3 and 320-S2. 'H NMR (400 MHz, CDC13): 5 7.90 - 6.68 (m, 8H), 5.57 (s, 1H), 2.38 (s,3H), 2.23 (s, 3H). [0584] The two enantiomers were separated by HPLC. Column: PIRKLE COVALENT, (R, R) Whelk-O 2 10/100, 25 cm x 21.1 mm. Flow: 30 ml/mm, 40% iPrOH/Hexanes-0.1% TFA. (Figure Remove) [0585] In the same manner as that described in Example 299 compound 321-S2 was prepared from 321-S1. 'H NMR (400 MHz, CDC13): 6 10.84 (s, 1H), 7.93 - 6.96 (m, 4H), 4.56 (s, 2H). [0586] To a solution of 321-S2 (1.2 g) in THF was added drop wise 6.2 mL MeLi (1.5 M) at -78 °C. The solution was stirred for 30 mins, quenched with aqueous NH4C1 solution, extracted with ethyl acetate, and dried. Purification with chromatography (hexanes/ethyl acetate 5:1) gave 321 (0.72 g) as a white solid. 'H NMR (400MHz, CDC13): 8 11.35 (s, 1H), 7.90 - 6.93 (m, 4H), 2.62 (q, 2H), 1.27 (t, 3H). (Figure Remove) [0587] In the same manner as that described in Example 28 compound 322 was prepared from 322-S1 and 322-S2. *H NMR (400 MHz, CDC13): 8 8.10 - 6.67 (m, 9H), 5.62 (s, 1 H), 2.72 (q,2H), 1.33 (t,3H). (Figure Remove) [0588] In the same manner as that described in Example 28 compound 323 was prepared from 323-S1 and 323-S2. 'H NMR (400 MHz, CDC13): 8 7.83 - 6.96 (m, 7H), 6.07 (s, 1H), 2.31 (s,3H),2.10(s,3H). (Figure Remove) [0589] In the same manner as that described in Example 28 compound 324 was prepared from 324-S1 and 324-S2. !H NMR (400 MHz, CDC13): 8 8.12 - 6.65 (m, 7H), 5.63 (s, 1H), 2.36 (s,2H), 2.22 (s,3H). (Figure Remove) [0590] To a solution of diazo compound 325-81(0.826 g, 3.02 mmol) in 1.5 N HC1 (36 mL) was added slowly solid N 82820)4 (619 mg, 3.02 mmol) at 0 °C. The mixture was stirred at 0 °C for 20 min, and quenched carefully with saturated aqueous NaHCCb solution. The mixture was extracted with EtOAc, washed with brine, dried and concentrated to give the phenyl hydrazine derivative 325-S2 as brown oil (156mg) which was used for next reaction without further purification. 1H NMR (400 MHz, CDC13): 5 6.96 (d,J=2.0Hz,lH), 6.71(dd, J=2.0 and 8.4 Hz,lH), 6.66 (d,J=8.4Hz,lH). [0591] A mixture of the above hydrazine derivative (177 mg, 1.03 mmol) and diacetyl mono-oxime (104 mg, 1.03 mmol) in CHzCla (5 mL) was stirred overnight at room temperature. The mixture was diluted with hexanes, and white solids were formed. After filtration and washing with hexanes, a white solid (138 mg) was obtained (325-S3). 'H NMR (400 MHz, CDC13): 6 7,89 (bs, 1H), 7.44 (d,J=2.4Hz,lH), 6.79(dd, J=2.8 and 8.8 Hz.lH), 6.73 (d,J=8.8Hz,lH), 3.88 (s,3H), 2.22(s,3H), 2.08 (s,3H). [0592] A mixture of the above white solid (130 mg), acetyl anhydride (1 mL), and NaOAc (42 mg) in DMF (3 mL) was heated at 100 °C overnight. The mixture was diluted with EtOAc, washed with saturated aqueous NaHCO3 solution and brine, dried and concentrated. Purification via flash column (5% to 30% EtOAc in hexanes) gave the triazole compound 325-S4 as colorless oil. 'H NMR (400 MHz, CDC13): 5 7.51 (d,J=2.8Hz,lH), 7.34 (dd, J=2.8 and 8.8 Hz,lH), 6.98 (d,J=8.8Hz,lH), 3.87 (s,3H), 2.33 (s,6H). [0593] To a solution of the above triazole compound (90 mg) in CHaCb (5 mL) was added drop wise BBr3 (0.15 mL) at -78 °C. The mixture was warmed to -20 °C over 2 hours, and quenched with saturated aqueous NaHC03 solution. The mixture was extracted with EtOAc, washed with brine, dried and concentrated to give the triazole phenol compound 325-S5 as an off-white solid (80 mg). 'H NMR (400 MHz, CDC13): 6 10.75 (s,lH), 8.0 (d,J=2.4Hz,lH), 7.14 (dd, J=2.8 and 8.8 Hz,lH), 7.01 (d,J=8.8Hz,lH), 2.38 (s,6H). [0594] The target compound 325 was prepared from 325-S5 and 325-S6 in the same manner as that described in Example 28. [0595] 'H NMR (400 MHz, CDC13): 5 7.87 (d,J=2.8Hz,lH), 7.47 (m,2H), 7.36-7.32 (m,3H), 7.08 (dd, J=2.8 and 8.8 Hz.lH), 6.77 (d,J=8.8Hz,lH), 5.63 (s,lH), 2.33 (s,6H). [0596] The two enantiomers were separated by HPLC. Column: PIRKLE COVALENT, (R, R) Whelk-0 2 10/100, 25 cm x 21.1 mm. Flow: 30 ml/min, 25% iPrOH/Hexanes-0.1% TFA. (Figure Remove) [0597] Compound 325 A was prepared from 325A-S1 and 325A-S2 in the same manner as that described in Example 28. 1H NMR (400 MHz, DMSO-d6): 8 7.60 (d,J=2.8Hz,lH), 7.54-7.44 (m,5H), 7.15 (d,J=9.2Hz,lH), 5.96 (s.lH), 2.26 (s,6H). [0598] The two enantiomers were separated by HPLC. Column: PIRKLE COVALENT, (R, R) Whelk-O 2 10/100, 25 cm x 21.1 mm. Flow: 30 ml/min, 30% iPrOH/Hexanes-0. 1% TFA. (Figure Remove) d 325B-S2 in the same manner as that described in Example 28. ]H NMR (400 MHz, DMSO-d6): 5 7.94 (d,J=2.4Hz,lH), 7.79-7.55 (m,5H), 7.20 (dd, J-2.8 and 9.2 hz,lH), 6.83 (d, J=9.2Hz,lH), 5.78 (s.lH), 2.42 (s, 6H). [0600] The two enantiomers were separated by HPLC. Column: PIRKLE COVALENT, (R, R) Whelk-O 2 10/100, 25 cm x 21. 1 mm. Flow: 30 ml/min, 30% iPrOH/Hexanes-0. 1 % TFA. (Figure Remove) [0601] In the same manner as that described in Example 28 compound 325C was prepared from 325C-S1 and 325CA-S2. (Figure Remove) [0602] Bromide 326-S2 was prepared by reaction of bromoacetyl bromide (1.0 eq.) and morpholine (1.0 eq.) with triethylamine (1.02 eq.) in CHbC^ at 0 °C for 1.5 h. To a solution of 326-S1 (1.99 g, 4.44 mmol) in DMF (10 mL) at rt was added K2CO3 (0.64 g, 9.30 mmol), and then followed by 326-S2 (1.55 g, 7.45 mmol). After stirring for 40 min at rt, the reaction mixture was diluted with EtOAc and aq. NFLjCl/HaO. The organic layer was washed with aq. NHUCl/HaO, and then brine/water, dried over Na2S(>4, concentrated in vacua. Purification via chromatography with EtOAc/hexanes (30% to 50%) to afforded 326 (1.34 g, 52%) as an off-white solid. 'H NMR (400 MHz, CDC13): 6 8.37 (1H, s), 8.25 (1H, s), 7.99 (1H, d, J = 7.2 Hz), 7.81 (1H, m), 7.68 (1H, d, J= 7.2 Hz), 7.56 (2H, m), 7.48 (1H, m), 7.38 (2H, m), 7.28 (1H, m), 6.02 (1H, s), 4.92 (1H, d, J = 14.0 Hz), 4.64 (1H, d, J= 14.0 Hz), 3.60-3.66 (6H, m), 3.27 (2H, m) ppm. (Figure Remove) [0603] To a solution of 327-S1 (2.16 g, 4.82 mmol) in DMF (10 mL) at rt was added K2CO3 (0.50 g, 3.62 mmol), and then followed by 327-S2 (1.42 g, 7.32 mmol). After stirring for 30 min at rt, the reaction mixture was diluted with EtOAc and aq. NH^jCl/HjO. The organic layer was washed with aq. MliCl/HaO, and then brine/water, dried over Na2SO4, concentrated in vacua. Purification via chromatography with EtOAc/hexanes (30% to 50%) to afforded 327 (2.05 g, 76%) as a white solid. 'H NMR (400 MHz, CDC13): 5 8.37 (1H, s), 8.24 (1H, d, J- 2.8 Hz), 8.00 (1H, d, J= 7.8 Hz), 7.81 (1H, m), 7.67 (1H, d, /= 7.8 Hz), 7.46-7.59 (3H, m), 7.30-7.39 (2H, m), 7.31 (IH, d, /= 8.8 Hz), 6.03 (IH, s), 4.97 (IH, d, J--14.2 Hz), 4.59 (IH, d, 7- 14.2 Hz), 3.45 (IH, m), 3.32 (IH, m), 3.15-3.31 (2H, m), 1.15 (6H, m) ppm. (Figure Remove) [0604] Bromide 328-S2 was prepared by reaction of bromoacetyl bromide (1.0 eq.) and pyrrolidine (1.0 eq.) with triethylamine (1.01 eq.) in C^Cla at -5 °C for 1.5 h. To a solution of 328-S1 (2.19 g, 4.90 mmol) in DMF (20 mL) at rt was added K2CO3 (0.66 g, 4.78 mmol), and then followed by bromide (1.41 g, 7.39 mmol). After stirring for 1 h at rt, the reaction mixture was diluted with EtOAc and aq. NH4C1/H2O. The organic layer was washed with aq. NH^CI/t^O, and then brine/water, dried over NaaSO,), concentrated in vacua. Purification via chromatography with EtOAc/hexanes (30% to 50%) to afforded 328 (1.91 g, 70%) as a white solid. 'H NMR (400 MHz, CDC13): S 8.38 (IH, s), 8.24 (IH, d, J= 2.8 Hz), 8.01 (IH, d, J = 7.4 Hz), 7.81 (IH, m), 7.68 (IH, d, J= 7.4 Hz), 7.50-7.59 (3H, m), 7.37-7.39 (2H, m), 7.30 (IH, d, J- 9.2 Hz), 6.04 (IH, s), 4.86 (IH, d,J= 14.4 Hz), 4.53 (IH, d, J- 14.4 Hz), 3.49 (2H, m), 3.28 (2H, m), 1.94 (2H, m), 1.84 (2H, m) ppm. (Figure Remove) (0605] In the same manner as that described in Example 328 compound 329 was prepared from 329-S1 and 329-S2. (m.p. 80-82 °C). 'H-NMR (400 MHz, ^-DMSO) 5 8.31 (s, 1H), 8.12 (d, 1H, J=2.4), 8.04 (d, 1H, J=7.6), 7.66-7.82 (m, 5H), 7.43-7.49 (m, 2H), 7.34 (d, 1H, J=9.2), 6.65 (s, 1H), 4.61 (s, 2H), 1.23 (s, 9H). Chiral HPLC conditions: 4.6 x 250 mm Regis Whelk-0-1 column; 970:30:1 hexanes/IPA/TFA @ 1.5 mL/min @ r.t.; detection at 220 run. Retention time of major enantiomer: 7.8 minutes. Retention time of the minor enatiomer: 8.2 minutes. (Figure Remove) [0606] In the same manner as that described in Example 329 compound 330 was prepared from 330-S1 and 329-S2. Melting point: 93-95 °C. (Figure Remove) [0607] To a flask under air was added 15.2 g (33.9 mmol) of 331-S1, 80 mL of CH2C12 and 80 mL of TFA (1040 mmol; 30.6 equiv.). After stirring at room temperature for 2 hours, 500 mL of heptane was added to the reaction mixture and the volatiles were removed via a rotatory evaporator at room temperature. The resulting white solid was further dried under vacuum to give 13.9 g of 331 as a white solid (m.p. 200-202 °C). 'H-NMR (400 MHz, de-DMSO) 5 13.2 (br, 1H), 8.31 (s, III), 8.12 (d, 1H, J=2.8), 8.03 (d, 1H, J=8.0), 7.63-7.81 (m, 5H), 7.42-7.49 (m, 2H), 7.36 (d, 1H, J=9.2), 6.65 (s, 1H), 4.66 (s, 2H). (Figure Remove) [0608] With the exception that 332-S1 (the racemic compound) was used as the starting material, this compound was synthesized via a procedure analogous to that used in the preparation of 331. 89% yield. Melting point: 208-210 °C. (Figure Remove) [0609] To a flask was added 3.08 g (22.3 mmol; 1.00 equiv.) of K2CO3) 50 mL of DMF, 10.0 g (22.3 mmol) of 333-S1 and 5.0 mL (48.4 mmol; 2.17 equiv.) of 2-ch\oro-N,N-dimethylacetamide. After stirring at room temperature for 6 hours, the reaction mixture was poured into 300 mL of EtOAc and washed with water 2 x 200 mL. To the organic phase was added 300 mL of heptane. The organic phase was concentrated to -300 mL via a rotatory evaporator and the resulting precipitate was collected in a filter funnel. After air drying, 10.6 g (89% yield) of a white solid (m.p. 145-147 °C) was obtained. 'H-NMR (400 MHz, dg-DMSO) 6 8.30 (s, 1H), 8.13 (d, 1H, J=2.4), 8.06 (d, 1H, J=8.4), 7.67-7.76 (m, 5H), 7.43-7.47 (m, 3H), 6.62 (s, 1H), 4.92 (d, 1H, J=14.8), 4.85 (d, 1H, 1=14.8), 2.83 (s, 3H), 2.77 (s, 3H). (Figure Remove) [0610] In the same manner as that described in Example 136 compound 340 was prepared from340-Sl. (Figure Remove) [0611] To a flask under air was added 8.96 g (20.0 mmol) of335-Sl, 100 mL of anhydrous DMF and 4.05 g (25.0 mmol; 1.25 equiv.) of l,l'-carbonyldiimidazole. After stirring at room temperature for 30 minutes, 6.6 mL (49.9 mmol; 2.50 equiv.) of 2-dimethylamino-ethanol was added. After stirring for an additional 2 hours at room temperature, the reaction mixture was poured into 500 mL of EtOAc and rinsed with water 3 x 250 mL. After phase separation, 500 mL of heptane was added to the organic phase. The organic phase was concentrated to - 200 mL via a rotaotory evaporator. The resulting precipitate was collected in a filter funnel and rinsed with heptane 2 x 50 mL. After air drying, 6.62 g (61% yield) of a white solid (m.p. 78-80 °C) was obtained. 'H-NMR (400 MHz, rftf-DMSO) 8 8.29 (s, 1H), 8.12 (d, 1H, J=2.4), 8..02 (d, 1H, J=8.0), 7.66-7.83 (m, 5H), 7.43-7.49 (m, 2H), 7.31 (d, 1H, J-8.8), 6.52 (s, 1H), 4.09 (m, 2H), 2.46 (m, 2H), 2.27 (q, 4H, J=7.2), 0.71 (t, 6H, J=7.2). (Figure Remove) [0612] This compound was synthesized via a procedure analogous to that used in the preparation of 335 with the exception that 2.50 equiv. of 2-pyrrolidin-l-yl-ethanol was used instead. 77% yield. Melting point: 97-99 °C. 'H-NMR (400 MHz, ^-DMSO) 6 8.30 (s, IH), 8.13 (d, IH, J=2.4), 8.02 (d, IH, J-7.6), 7.65-7.83 (m, 5H), 7.45-7.48 (m, 2H), 7.31 (d, IH, J-8.8), 6.55 (s, IH), 4.13 (m, 2H), 2.46 (m, 2H), 2.21 (m, 4H), 1.46 (m, 4H). (Figure Remove) [0613] This compound was synthesized via a procedure analogous to that used in the preparation of 335 with the exception that 2.50 equiv. of 2-morpholin-4-yl-ethanol was used instead. 82% yield. Melting point: 93-95 °C. 'H-NMR (400 MHz, Jtf-DMSO) 8 8.30 (s, IH), 8.13 (d, IH, J=2.4), 8.02 (d, IH, J=8.0), 7.67-7.82 (m, 5H), 7.45-7.50 (m, 2H), 7.31 (d, IH, J-9.2), 6.55 (s, IH), 4.19 (m, IH), 4.11 (m, IH), 2.46 (m, 2H), 3.28 (m, 4H), 2.32 (m, 2H), 2.10(m,4H). (Figure Remove) [0614] To a solution of 338-S1 (2.35 g, 5.25 mmol) in DMF (15 mL) at rt was added K2CO3 (1.06 g, 7.67 mmol), and then followed by chloromethyl pivalate (2.0 mL, 13.5 mmol). After stirring for 1 h at 40 °C, the reaction mixture was diluted with EtOAc and aq. NH4C1/H2O. The organic layer was washed with aq. NKjCl/^O, and then brine/water, dried over NaaSO4, concentrated in vacuo. Purification via chromatography with EtOAc/hexanes (10% to 20%) to afforded 338 (1.19 g, 40%) as a white solid. *H NMR (400 MHz, CDC13): 5 8.32 (IH, s), 8.27 (IH, d, J = 2.8 Hz), 7.92 (IH, d, 7= 7.2 Hz), 7.82 (IH, m), 7.68 (IH, d,/= 7.2 Hz), 7.54-7.58 (2.H, m), 7.38-7.43 (3H, m), 6.97 (IH, d, 7- 8.8 Hz), 5.89 (IH, s), 5.81 (IH, d, J= 5.4 Hz ), 5.72 (IH, d, J= 5.4 Hz ), 1.04 (9H, s) ppm. In vivo Activities [0615] The anti-diabetic activities of the compounds were evaluated in the C57BL/6J ob/ob Mice model. A. Materials and methods [0616J Male, 7-9 weeks old, C57BL/6J ob/ob mice were purchased from The Jackson Laboratory (Bar Harbor, ME, USA). Animals were housed (4-5 mice/cage) under standard laboratory conditions at 22 ± 3°C temperature and 50 ± 20% relative humidity, and were maintained on a diet of Purina rodent chow and water ad libitum. Prior to treatment, blood was collected from the tail vein of each animal. Mice that had non-fasting plasma glucose levels between 250 and 500 mg/dl were used. Each treatment group consisted of 8-10 mice that were distributed so that the mean glucose levels were equivalent in each group at the start of the study. Mice were dosed orally by gavage once a day for 1-4 days with vehicle and one or more dose of test compound at a dose ranging from 5 to 125 mg/kg. Compounds were delivered in a liquid formulation containing 5% (v/v) dimethyl sulfoxide (DMSO), 1% (v/v) Tween 80® and 0.9% (w/v) methylcellulose. The gavage volume was 10 ml/kg, Blood samples were taken at 6 hours after the each dose and analyzed for plasma glucose. Food intake and body weight were measured daily. Plasma glucose concentrations were determined colorimetrically using a commercial glucose oxidase method (Sigma Chemical Co, St. Louis, MO, USA). Significant difference between groups (comparing drug-treated to vehicle-treated) was evaluated using the Student unpaired t-test. B. Results [0617] Figure 6 illustrates the anti-diabetic effects of selected compounds of the present invention. Table 15 provides the relative potency of some of these selected compounds. Compounds that are effective for glucose lowering at the dose of>125 mg/kg are assigned a potency of+; compounds that are effective for glucose lowering at a dose of >25 mg/kg but (Table Remove) [0618] It is understood that the examples and embodiments described herein are for illustrative purposes only and that various modifications or changes in light thereof will be suggested to persons skilled in the art and are to be included within the spirit and purview of this application and scope of the appended claims. All publications, patents, and patent applications cited herein are hereby incorporated by reference in their entirety for all purposes. WHAT IS CLAIMED IS: (Figure Remove) X is a member selected from the group consisting of 0, S, SO, S02 and NR, wherein R is H, (C,-C8)alkyl, CORa, COORa and CONRaRb wherein Ra and Rb are each independently selected from the group consisting of H and (Ci-Cg)alkyl; Y is a member selected from the group consisting of CH2ORC, C02R°, CHO, CONRcRm, CH(=NRC), CH(=NORC) and carboxylic acid surrogates, wherein Rc is a member selected from the group consisting of H, (Ci-Cg)alkyl, (C$-C8)alkenyl, (Cj-Cg)alkynyl, (C3-C7)cycloalkyl, (C4-C8)cycloalkyl-alkyl, aryl, aryl(C|-C8)alkyl and (Ci-C8)alkylene-Z, wherein Z is selected from the group consisting of CORd, COORd, NRdRc, NRdCONRcRf, NRdCORe, NRdCOORe and CONRdRe wherein Rd, Re and Rf are each independently selected from the group consisting of H, (C|-C8)alkyl and phenyl, or optionally two of Rd, Re and Rf when attached to the same nitrogen atom are combined to form a five-or six-membered ring; and wherein Rm is selected from the group consisting of H, (C|-C8)alkyl, aryl, OH and S02Rn, wherein Rn is selected from the group consisting of (C,-C8)alkyl, (Ci-Cg)haloalkyl, aryl(Ci-C8)alkyl, (Cr C8)heteroalkyl, aryl, heteroaryl, (Ci-C8)alkoxy, aryloxy, alkylamino, dialkylamino, arylamino, diarylamino, haloalkylamino and di(haloalkyl)amino, and Rm and Rc are optionally combined with the nitrogen atom to which each is attached to form a five- or six-membered ring; HAr is heteroaryl moiety, optionally substituted with from one to three substituents independently selected from the group consisting of halogen, hydroxy, (Cr C8)alkyl, aryl(C,-C8)alkyl, (C,-C8)alkoxy, (C2-C8)alkenyl, (C2-Cg)alkynyl, (C3-C7)cycloalkyl, (C4-C8)cycloalkyl-alkyl, (C|-C8)heteroalkyl, (C2- Cs)heterocyclyl, aryl, aryloxy, heterosubstituted(C3-C7)cycloalkyl, heteroalkyl substituted (C.rC7)cycloalkyl, (Ci-Cg)haloalkyl, O(Ci-C8)haloalkyl, nitro, cyano, C02Rg, CORg, NRgRh, S(0)qRg, S02NRgRh, NR'CONR"^, NRgCORh, NRgCOORh and CONR6Rh, wherein Re, Rh and R1 are each independently selected from the group consisting of H and (Ci-Cg)alkyl, or optionally two of Rg, Rh and R1 when attached to the same nitrogen atom are combined to form a five- or six-membered ring, and the subscript q is an integer of from 0 to 2; each R1 and R3 is a member independently selected from the group consisting of halogen, hydroxy, (C|-C8)alkyl, (C2-C8)alkenyl, (CrC8)alkynyl, (Cr C8)alkoxy, (C3-C7)cycloalkyl, (C4-C8)cycloalkyl-alkyl, (C]-C8)haloalkyl, (Cr Cg)heteroalkyl, (C2-C5)heterocyclyl, heterosubstituted(C3-C7)cycloalkyl, heteroalkyl substituted (C3-C7)cycloalkyl, 0(Ci-C8)haIoalkyl, nitro, cyano, phenyl, O-phenyl, NRj-phenyl, S(O)rphenyl, CORj, COORj, NRJRk, S(O)rRj, SO2NRJRk, NRjCOKRkR', NRjCORk, NRjCOORk and CONRjRk wherein the phenyl ring is optionally substituted and R", Rk and R1 are each independently selected from the group consisting of H, (Ci-Cg)alkyl and (Ci-C8)haloalkyl, or optionally two of R", Rk and R1 when attached to the same nitrogen atom are combined to form a five- or six-membered ring, and the subscript r is an integer of from 0 to 2; R2 is a member selected from the group consisting of H, (Ci-Cg)alkyl, (Ci- Cs)haloalkyl, aryl(C|-Cg)alkyl and (Ci-C^alkylene-Z, wherein Z is as defined above; the subscript m is an integer of from 0 to 4; the subscript p is an integer of from 0 to 3; and pharmaceutically acceptable salts thereof. 2. A compound of claim 1, wherein Y is selected from the group consisting of CH2ORC, CO2RC, tetrazol-5-yl, CONHSO2R"and CHO. 3. A compound of claim 1, wherein Y is selected from the group consisting of CH2ORC, tetrazol-5-yl, CONHSO2Rn and CO2RC. 4. A compound of claim 3, wherein HAr is a fused bicyclic heteroaryl moiety, wherein each of said HAr groups is optionally substituted with from one to three substituents independently selected from the group consisting of halogen, (Ci-C4)alkyl, aryl, aryloxy, (C,-C4)alkoxy, (C|-C4)haloalkyl, 0(Ci-C4)haloalkyl, nitro, cyano, C02Rg, COR8 and CONRgRb. 5. A compound of claim 4, wherein X is selected from the group consisting of O, S and NH. 6. A compound of claim 5, wherein R2 is selected from the group consisting of H, CHj and CF}. 7. A compound of claim 6, wherein HAr is attached to the 2- or 3- position of the ring bearing X and is selected from the group consisting of: (Figure Remove) wherein each of said HAr groups is optionally substituted with from one to three substituents independently selected from the group consisting of halogen, (Ci-C4)alkyl, (Ci-C^alkoxy, (C|-C4)haloalkyl, O(CrC4)haloalkyl, nitro, cyano, C02R6, COR6 and CONRgRh, and wherein the wavy line indicates the point of attached to the ring bearing X through attachment to any available ring member in either ring of HAr. 8. A compound of claim 7, wherein the subscript m is 0 to 2 and each R3 when present is independently selected from the group consisting of halogen, (Ci-C4)alkyl, (Ci-C4)alkoxy, (d-Q)haloalkyl, O(C[-C4)haloalkyl, nitro, cyano, phenyl, O-phenyl, NRj-phenyl and S(0)r-phenyl. 9. A compound of claim 8, wherein p is an integer of from 0 to 2 and each R1 when present is independently selected from the group consisting of halogen, (Cr C4)alkyl, (C|-C4)alkoxy, (Ci-C4)haloalkyl, 0(d-C4)haloalkyl, nitro, cyano, phenyl, O- phenyl, NRJ-phenyl and S(O)r-phenyl. 10. A compound of claim 9, wherein m is an integer of from 0 to 2; each R3 when present is independently selected from the group consisting of halogen, (d- C4)alkyl, (CrC4)alkoxy, (C|-C4)haloalkyl, 0(Ci-C4)haloalkyl, nitro, cyano, phenyl, O- phenyl, NRJ-phenyl and S(O)r-phenyl; p is an integer of from 0 to 2; and each R1 is independently selected from the group consisting of halogen, (C|-C4)alkyl, (C]-C4)alkoxy, (Ci-C4)haloalkyl, O(CrC4)haloalkyl, nitro, cyano, phenyl, O-phenyl, NRj-phenyl and S(O)r- phenyl. 11. A compound of claim 7, having a formula selected from the group consisting of: (Figure Remove) wherein the subscript m is an integer of from 0 to 2, the subscript p is an integer of from 0 to 2, and R1 and R3 are each independently selected from the group consisting of halogen, (Ci-C4)alkyl, (Ci-C4)alkoxy, (C|-C4)haloalkyl, 0(Ci-C4)haloalkyl, nitro, cyano, phenyl, O-phenyl, NRJ-phenyl and S(O)r-phenyl; and R" is selected from the group consisting of (Ci-Cg)alkyl, (Ci-Cg)haloalkyl, aryl(C,-Cg)alkyl, (C,-C8)heteroalkyl, aryl, heteroaryl, (Cr Ca)alkoxy, aryloxy, alkylarnino, dialkylamino, arylamino, diarylamino, haloalkylamino and di(haloalkyl)amino. 12. A compound of claim 11, wherein HAr is selected from the group consisting of (Figure Remove) wherein each of said HAr groups is optionally substituted with from one to three substituents independently selected from the group consisting of halogen, (Ci-C^alkyl, (C|-C()alkoxy, (C,-C4)haloalkyl, 0(C,-C4)haloalkyl, nitro, cyano, C02Rg, CORg and CONRgRh. 13. A compound of claim 12, wherein HAr is selected from the group consisting of (Figure Remove) wherein each of said HAr groups is optionally substituted with from one to three substituents independently selected from the group consisting of halogen, (Ci-C-Oalkyl, (Ci-C/Oalkoxy, (C,-C4)haloalkyl, 0(C,-C4)haloalkyl, nitro, cyano, C02RC, CORC and CONRcRd. 14. A compound of claim 13, wherein HAr is 2-benzoxazolyl; R2 is H or CHj; the subscript m is 0 or 1, and p is 1 or 2; and R1 and R3 are each independently selected from the group consisting of halogen, (C|-C4)alkyl, (Ci-C^alkoxy, (Ci-C^haloalkyl, O(Cr C4)haloalkyl, nitro, cyano, CO2RB, CORB and CONR8Rh. 15. A compound of claim 13, wherein HAr is 2-benzothiazolyl; R2 is H or ; the subscript m is 0 or 1, and p is 1 or 2; and R1 and R3 are each independently selected from the group consisting of halogen, (Ci-C4)alkyl, (Ci-C-Oalkoxy, (Ci-C4)haloalkyl, O(CV C4)haloalkyl, nitro, cyano, C02RB, COR8 and CONR8Rh.. 16. A compound of claim 13, wherein HAr is 2-benzotriazolyl; R2 is H or CH3; the subscript m is 0 or 1, and p is 1 or 2; and R1 and R3 are each independently selected from the group consisting of halogen, (Ci-C4)alkyl, (Ci-C4)alkoxy, (Ci-C4)haloalkyl, O(C|- C4)haloalkyl, nitro, cyano, CO2R8, COR8 and CONRgRh.. 17. A compound of claim 3, wherein HAr is a monocyclic heteroaryl moiety, wherein each of said HAr groups is optionally substituted with from one to three substituents independently selected from the group consisting of halogen, (Ci-C4)alkyl, (C|- C8)heteroalkyl, (CrC4)alkoxy, (C|-C4)haloalkyl, O(Ci-C4)haloalkyl, aryl(Ci-C4)alkyl, aryl, heteroaryl, nitro, cyano, CO2R8, CORg and CONRgRh. 18. A compound of claim 17, wherein X is selected from the group consisting of O, S and NH. 19. A compound of claim 18, wherein R2 is selected from the group consisting of H, CH3 and CF3, 20. A compound of claim 19, wherein HAr is attached to the 2- or 3- position of the phenyl ring bearing X and is selected from the group consisting of (Figure Remove) wherein each of said HAr groups is optionally substituted with from one to three substituents independently selected from the group consisting of halogen, (Ci~C4)alkyl, (Cr C8)heteroalkyl, (C,-C4)alkoxy, (C|-C4)haloalkyl, O(C,-C4)ha!oalkyl, aryl(Ci-C4)alkyl, aryl, heteroaryl, nitro, cyano, CC^R8, COR8 and CONR8Rh, and the wavy line indicates the attachment to the ring bearing X. 21. A compound of claim 20, wherein m is 0 to 2 and each R3 when present is independently selected from the group consisting of halogen, (Ci-C4)alkyl, (Ci- C4)alkoxy, (Ci-C4)haloalkyl, 0(Ci-C4)haloalkyl, nitro, cyano, phenyl, 0-phenyl, NRJ-phenyl and S(O)r-phenyl. 22. A compound of claim 21, wherein p is 0 to 2 and each R1 when present is independently selected from the group consisting of halogen, (Ci-C4)alkyl, (Ci-C4)alkoxy, (CrC4)haloalkyl, O(CVC4)haloalkyl, nitro, cyano, phenyl, O-phenyl, NRj-phenyl and S(O)r- phenyl. 23. A compound of claim 22, wherein m is an integer of from 0 to 2; each R3 is independently selected from the group consisting of halogen, (C]-C4)alkyl, (Cr C4)alkoxy, (Ci-C4)haloalkyl, 0(C|-C4)haloalkyl, nitro and cyano; p is an integer of from 0 to 2; and each R1 is independently selected from the group consisting of halogen, (d-C4)alkyl, (C,-C4)alkoxy, (CrC4)haloalkyl, 0(C,-C4)haloalkyl, nitro and cyano. 24. A compound of claim 20, having a formula selected from the group consisting of: (Figure Remove) wherein m is an integer of from 0 to 2, p is an integer of from 0 to 2, and R1 and R3 are each independently selected from the group consisting of halogen, (Ci-C4)alkyl, (Ci-C4)alkoxy, (Ci-C4)haloalkyl, O(C]-C4)haloalkyl, nitro, cyano, phenyl, O-phenyl, NRj-phenyl and S(0)r phenyl; and Rn is selected from the group consisting of (Ci-Cg)alkyl, (Ci-Cg)haloalkyl, aryl(Ci-Cg)alkyl, (Ci-Cg)heteroalkyl, aryl, heteroaryl, (Ci-C8)alkoxy, aryloxy, alkylamino, dialkylamino, arylamino, diarylamino, haloalkylamino and di(haloalkyl)amino. 25. A compound of claim 24, wherein HAr is selected from the group consisting of (Figure Remove) wherein each of said HAr groups is optionally substituted with from one to three substituents independently selected from the group consisting of halogen, (Ci-C4)alkyl, (Ci-C8)heteroalkyl, (CrC4)alkoxy, (C|-C4)haloalkyl, O(CrC4)haloalkyl, aryl(C|-C4)alkyl, aryl, heteroaryl, nitro, cyano, CO2RB, COR8 and CONRERh. 26. A compound of claim 24, wherein HAr is selected from the group consisting of (Figure Remove) wherein each of said HAr groups is optionally substituted with from one to two substituents independently selected from the group consisting of halogen, (Ci-C4)alkyl, (Ci-C8)heteroalkyl, (C,-C4)alkoxy, (CrC4)haloalkyl, O(C,-C4)haloalkyl, aryl(C1-C4)alkyl, aryl, heteroaryl, nitro, cyano, CO2Rg, COR8 and CONR8Rh. 27. A compound of claim 26, wherein m is an integer of from 0 to 2, p is an integer of from 0 to 2, R1 and R3 are each independently selected from the group consisting of F, Cl, Br, (C,-C4)alkyl, (C,-C4)alkoxy, (CrC4)haloalkyl, O(C,-C4)haloalkyl, CN, N02 and phenyl. 28. A compound of claim 27, wherein HAr is optionally substituted 2-, 4- or 5-thiazolyl wherein the thiazolyl is optionally substituted with from one to two substituents selected from the group consisting of F, Cl, Br, (Ci-C4)alkyl, aryl(d-C4)alkyl, (Ci- C4)alkoxy, (CrC4)haloalkyl, O(C|-C4)haloalkyl, CN and phenyl; R2 is H or CH3; the subscript m is 0 or 1 and p is 1 or 2; and R1 and R3 are each independently selected from the group consisting of F, Cl, Br, (Ci-C4)alkyl, (CrC4)alkoxy, (d-C4)haloalkyl, O(Ci- C4)haloalkyl, CN, NO2 and phenyl. 29. A compound of claim 27, wherein HAr is selected from the group consisting of optionally substituted 1, 3, 4 or 5-pyrazolyl wherein the pyrazolyl is optionally substituted with from one to two substituents selected from the group consisting of F, Cl, Br, (C|-C4)alkyl, aryl(C,-C4)alkyl, (Ci-C4)alkoxy, (Ci-C4)haloalkyl, O(CrC4)haloalkyl, CN and phenyl; R2 is H or CHj; the subscript m is 0 or 1 and p is 1 or 2; and R1 and R3 are each independently selected from the group consisting of F, Cl, Br, (Ci-C4)alkyl, (Ci-C4)alkoxy, (C,-C4)haloalkyl, O(C,-C4)haloalkyl, CN, NO2 and phenyl. 30. A compound of claim 27, wherein HAr is optionally substituted 2-, 4- or 5-oxazolyl wherein the oxazolyl is optionally substituted with from one to two substituents selected from the group consisting of F, Cl, Br, (Ci-C4)alkyl, aryl(Ci-C4)alkyl, (C\- C4)alkoxy, (CrC4)haloalkyl, O(C|-C4)haloalkyl, CN and phenyl; R2 is H or CH3; the subscript m is 0 or 1 and p is 1 or 2; and R1 and R3 are each independently selected from the group consisting of F, Cl, Br, (CrC4)alkyl, (Ci-C4)alkoxy, (Ci-C4)haloalkyl, 0(C,- C4)haloalkyl, CN, NO2 and phenyl. 31. A compound of claim 27, wherein HAr is optionally substituted 1,2,3- triazol-2-yl wherein the l,2,3-triazol-2-yl is optionally substituted with from one to two substituents selected from the group consisting of F, Cl, Br, (Ci-C4)alkyl, aryl(Ci-C4)alkyl, (Ci-C4)alkoxy, (Ci-C4)haloalkyl, 0(C]-C4)haloalkyl, CN and phenyl; R2 is H or CH3; the subscript m is 0 or 1 and p is 1 or 2; and R1 and R3 are each independently selected from the group consisting of F, Cl, Br, (Ct-C4)alkyI, (Ci-C4)alkoxy, (Ci-C4)haloalkyl, 0(C|-C4)haloalkyl, CN, NO2 and phenyl. 32. A composition comprising a pharmaceutically acceptable excipient and a compound having the formula: (Figure Remove) wherein X is a member selected from the group consisting of 0, S, SO, 862 and NR, wherein R is H, (Ci-Cg)alkyl, CORa, COOR" and CONRaRb wherein Ra and Rb are each independently selected from the group consisting of H and (Ci-Cs)alkyl; Y is a member selected from the group consisting of CH2ORC, COaR0, CHO, CONRcRm, CH(=NRC), CH(=NORC) and carboxylic acid surrogates, wherein Rc is a member selected from the group consisting of H, (Ci-Cg)alkyl, (€3-Cg)alkenyl, (C3-C8)alkynyl, (C3-C7)cycloalkyl, (C4-C8)cycloalkyl-alkyl, aryl, aryl(C|-C8)alkyl and (Ci-Cg)alkylene-Z, wherein Z is selected from the group consisting of CORd, COORd, NRdRc, NRdCONReRf, NRdCORe, NRdCOORe and CONRdRe wherein Rd, Re and Rf are each independently selected from the group consisting of H, (Ci-Cg)alkyl and phenyl, or optionally two of Rd, Rc and Rf when attached to the same nitrogen atom are combined to form a five-or six-membered ring; and wherein Rm is selected from the group consisting of H, (Ci-C8)alkyl, aryl, OH and S02Rn, wherein Rn is selected from the group consisting of (CrC8)alkyl (Ci-Cg)haloalkyl, (Ci-Cg)aralkyl, (d-Cg)heteroalkyl, aryl, heteroaryl, (Ci-Cg)alkoxyl, aryloxyl, alkylamino, dialkylamino, arylamino, diarylamino, haloalkylamino and di(haloalkyl)amino; and Rm and Rc are optionally combined with the nitrogen atom to which each is attached to form a five- or six-membered ring; HAr is heteroaryl moiety, optionally substituted with from one to three substituents independently selected from the group consisting of halogen, hydroxy, (Ci-C8)alkyl, aryl(Ci-C8)alkyl, (C,-C8)alkoxy, (C2-C8)alkenyl, (C2-Cg)alkynyl, (C3-C7)cycloalkyl, (C4-C8)cycloalkyl-alkyl, (C,-Cg)heteroalkyl, (C2-C5)heterocyclyl, aryl, aryloxy, heterosubstituted(C3-C7)cycloalkyl, heteroalkyl substituted (C3-C7)cycloalkyl, (Ci-Cg)haloalkyl, 0(C|-C8)haloalkyl, nitro, cyano, CO2Rg, CORg, NRgRh, S(O)qRB, S02NR8Rh, NRgCONRhRi, NRgCORh, NRgCOORh and CONRgRh, wherein RE, Rh and Rj are each independently selected from the group consisting of H and (Ci-Cg)alkyl, or optionally two of RE, Rh and R1 when attached to the same nitrogen atom are combined to form a five- or six-membered ring, and the subscript q is an integer of from 0 to 2; each R1 and R3 is a member independently selected from the group consisting of halogen, hydroxy, (Ci-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, (C,-C8)alkoxy, (C3-C7)cycloalkyl, (Q-Cg)cycloalkyl-alkyl, (C,-C8)haloalkyl, (d-Cg)heteroalkyl, (C2-C5)heterocyclyl, heterosubstituted(C3-C7)cycloalkyl, heteroalkyl substituted (CrC7)cycloalkyl, O(Ci-C8)haloalkyl, nitro, cyano, phenyl, O-phenyl, NRj-phenyl, S(O)r-phenyl, CORj, COOR', NRjRk, S(O)rRj, S02NRjRk, NRJCONRkR', NRjCORk, NRjCOORk and CONRjRk wherein the phenyl ring is optionally substituted and R*, R and R1 are each independently selected from the group consisting of H, (Ci-Cg)alkyl and (Ci-Cg)haloalkyl( or optionally two of Rj, Rk and R1 when attached to the same nitrogen atom are combined to form a five- or six-membered ring, and the subscript r is an integer of from 0 to 2; R2 is a member selected from the group consisting of H, (Ci-Cg)alkyl, (Ci- Cg)haloalkyl, aryl(Ci-C8)alkyl and (Ci-C4)alkylene-Z, wherein Z is as defined above; the subscript m is an integer of from 0 to 4; the subscript p is an integer of from 0 to 3; and pharmaceutically acceptable salts thereof. 33. A composition in accordance with claim 32, wherein Y is selected from the group consisting of CH2ORC, C02RC, tetrazol-5-yl, CONHS02Rnand CHO. 34, A composition in accordance with claim 33, wherein Y is selected from the group consisting of CH2ORC, tetrazol-5-yl, CONHSO2Rnand CO2RC. 35. A composition in accordance with claim 34, wherein HAr is a fused bicyclic heteroaryl moiety, wherein each of said HAr groups is optionally substituted with from one to three substituents independently selected from the group consisting of halogen, (C|-C4)alkyl, aryl, aryloxy, (Ci-C4)alkoxy, (Ci-C4)haloalkyl, O(Ci-C4)haloalkyl, nitro, cyano, C02R8, COR8 and CONRgRh. 36. A composition in accordance with claim 35, wherein X is selected from the group consisting of 0, S and NH. 37. A composition in accordance with claim 36, wherein R2 is selected from the group consisting of H, CHa and CF3. 38. A composition in accordance with claim 37, wherein HAr is attached to the 2- or 3-position of the ring bearing X and is selected from the group consisting of: (Figure Remove) wherein each of said HAr groups is optionally substituted with from one to three substituents independently selected from the group consisting of halogen, (Ci-C4)alkyl, (Ci-C4)alkoxy, (d-C4)haloalkyl, 0(Ci-C4)haloalkyl, nitro, cyano, C02RB,.COR8 and CONRgRh, and wherein the wavy line indicates the point of attached to the ring bearing X through attachment to any available ring member in either ring of HAr 39. A composition in accordance with claim 38, wherein m is from 0 to 2; and each R3 when present is independently selected from the group consisting of halogen, (C,-C4)alkyl, (Ci-C4)alkoxy, (Ci-C4)haloalkyl, 0(Ci-C4)haloaIkyl, nitro, cyano, phenyl, O- phenyl, NRj-phenyl and S(O)r-phenyl. 40. A composition in accordance with claim 39, wherein p is from 0 to 2; and each R1 when present is independently selected from the group consisting of halogen, (CrC4)alkyl, (Ci-C4)alkoxy, (Ci-C4)haloalkyl, 0(Ci-C4)haloalkyl, nitro, cyano, phenyl, O- phenyl, NRJ-phenyl and S(O)r-phenyl. 41. A composition in accordance with claim 40, wherein m is an integer of from 0 to 2; each R3 is independently selected from the group consisting of halogen, (Cr C4)alkyl, (CrC4)alkoxy, (CrC4)haloalkyI, O(CrC4)haloalkyl, nitro, cyano, phenyl, O- phenyl, NR'-phenyl and S(O)r-phenyl; p is an integer of from 0 to 2; and each R1 is independently selected from the group consisting of halogen, (Ci-C4)alkyl, (Ci-C4)alkoxy, (C|-CV)haloalkyl, O(C|-C4)haloalkyl, nitro, cyano, phenyl, O-phenyl, NR'-phenyl and S(0)r- phenyl. 42. A composition in accordance with claim 38, having a formula selected from the group consisting of: (Figure Remove) wherein the subscript m is an integer of from 0 to 2; the subscript p is an integer of from 0 to 2; R1 and R3 are each independently selected from the group consisting of halogen, (Ci-C4)alkyl, (CrC4)aIkoxy, (Ci-C4)haloalkyl, O(Ci-C4)haloalkyl, nitro, cyano, phenyl, 0-phenyl, NRJ-phenyl and S(O)r-phenyl; and Rn is selected from the group consisting of (C|-C8)alkyl, (Ci-Cg)haloalkyl, aryl(CrCg)alkyl, (Ci-Cg)heteroalkyl, aryl, heteroaryl, (Cr Cg)alkoxy, aryloxy, alkylamino, dialkylamino, arylamino, diarylamino, haloalkylamino and di(haloalkyl)amino. 43. A composition in accordance with claim 42, wherein HAr is selected from the group consisting of (Figure Remove) wherein each of said HAr groups is optionally substituted with from one to three substituents independently selected from the group consisting of halogen, (Ci-C4)alkyl, (CrC4)alkoxy, (Ci-C4)haloalkyl, 0(C,-C4)haloalkyl, nitro, cyano, CO2Rg, CORE and CONRgR1'. 44. A composition in accordance with claim 42, wherein HAr is selected from the group consisting of (Figure Remove) wherein each of said HAr groups is optionally substituted with from one to three substituents independently selected from the group consisting of halogen, (Ci-C4)alkyl, (Ci-C4)alkoxy, (C,-C4)haloalkyl, O(Ci-C4)haloalkyl, nitro, cyano, C02Rg, CORg and CONR8Rh. 45, A composition in accordance with claim 34, wherein HAr is a monocyclic heteroaryl moiety, wherein each of said HAr groups is optionally substituted with from one to three substituents independently selected from the group consisting of halogen, (Ci-C4)alkyl, (C,-C8)heteroalkyl, (C,-C4)alkoxy, (C|-C4)haloalkyl, O(Ci-C4)haloalkyl, aryl(Ci-C4)alkyl, aryl, heteroaryl, nitro, cyano, C02Rg, COR8 and CONRgRh. 46. A composition in accordance with claim 45, wherein X is selected from the group consisting of O, S and NH. 47. A composition in accordance with claim 46, wherein R2 is selected from the group consisting of H, CHs and CF3. 48. A composition in accordance with claim 47, wherein HAr is attached to the 2- or 3-position of the phenyl ring bearing X and is selected from the group consisting of (Figure Remove) wherein each of said HAr groups is optionally substituted with from one to three substituents independently selected from the group consisting of halogen, (Ci-C4)alkyl, (Ci-Cg)heteroalkyl, (d-C^alkoxy, (C,-C4)haloalkyl, 0(Ci-C4)haloalkyl, aryl(C,-C4)alkyl, aryl, heteroaryl, nitro, cyano, CO2R8, COR8 and CONRERh, and the wavy line indicates the attachment to the ring bearing X. 49. A composition in accordance with claim 48, wherein each R3 is independently selected from the group consisting of halogen, (Ci-C4)alkyl, (Ci-C4)alkoxy, (Ci-C4)haloalkyl, O(C,-C4)haloalkyl, nitro, cyano, phenyl, 0-phenyl, NRj-phenyl and S(O)r- phenyl. 50. A composition in accordance with claim 49, wherein each R1 is independently selected from the group consisting of halogen, (Ci-C4)alkyl, (C|-C4)alkoxy, (C|-C4)haloalkyl, O(C|-C4)haloalkyl, nitro, cyano, phenyl, O-phenyl, NRj-phenyl and S(O)r- phenyl. 51. A composition in accordance with claim 50, wherein m is an integer of from 0 to 2; each R3 is independently selected from the group consisting of halogen, (d- C4)alkyl, (Ci-C4)alkoxy, (C|-C4)haloalkyl, O(Ci-C4)haloalkyl, nitro and cyano; p is an integer of from 0 to 2; and each R1 is independently selected from the group consisting of halogen, (CrC4)alkyl, (d-C4)alkoxy, (Ci-C4)haloalkyl, 0(d-C4)haloalkyl, nitro and cyano. 52. A composition in accordance with claim 48, having a formula selected from the group consisting of: (Figure Remove) wherein m is an integer of from 0 to 2; p is an integer of from 0 to 2; R1 and R3 are each independently selected from the group consisting of halogen, (Ci-C4)alkyl, (d-C4)alkoxy, (Ci-C4)haloalkyl, O(CrC4)haloalkyl, nitro, cyano, phenyl, O-phenyl, NRJ-phenyl and S(0)r-phenyl; and Rn is selected from the group consisting of (Ci-C8)alkyl, (Ci-Cg)haloalkyl, aryl(C|-Cg)alkyl, (Ci-Csjheteroalkyl, aryl, heteroaryl, (Ci-C8)alkoxy, aryloxy, alkylamino, diakylamino, arylarnino, diarylamino, haloalkylamino and di(haloalkyl)amino. 53. A composition in accordance with claim 52, wherein HAr is selected from the group consisting of (Figure Remove) wherein each of said HAr groups is optionally substituted with from one to three substituents independently selected from the group consisting of halogen, (C|-C4)alkyl, (C|-C8)heteroalkyl, (CrC4)alkoxy, (C,-C4)haloalkyl, O(Ci-C4)haloalkyl, aryl(C|-C4)alkyl, aryl, heteroaryl, nitro, cyano, CO2Rg, COR8 and CONReRh. 53. A composition in accordance with claim 52, wherein HAr is selected from the group consisting of (Figure Remove) 54. wherein each of said HAr groups is optionally substituted with from one to three substituents independently selected from the group consisting of halogen, (d-C^alkyl, (Cr C8)heteroalkyl, (Ci-C,)alkoxy, (Ci-C4)haloalkyl, O(Ci-C4)haloalkyl, aryl(C,-C4)alkyl, aryl, heteroaryl, nitro, cyano, C02Rg, COR6 and CONRERh. 55. A composition in accordance with claim 54, wherein m is an integer of from 0 to 2; p is an integer of from 0 to 2; and R1 and R3 are each independently selected from the group consisting of F, Cl, Br, (CrC4)alkyl, (Ci-C4)alkoxy, (Ci-C4)haloalkyl, O(C,- C4)haloalkyl, nitro, cyano, phenyl, 0-phenyl, NRj-phenyl and S(0)r-phenyl. 56. A method for treating Type 2 diabetes in a subject, said method comprising administering to said subject a therapeutically effective amount of a compound having the formula: (Figure Remove) X is a member selected from the group consisting of 0, S, SO, SOj and NR, wherein R is H, (C,-C8)alkyl, COR", COORa and CONRaRb wherein Ra and Rb are each independently selected from the group consisting of H and (Ci-Cg)alkyl; Y is a member selected from the group consisting of CF^OR0, CC^R0, CHO, CONRcRm, CH(=NRC), CH(=NORC) and carboxylic acid surrogates, wherein Rc is a member selected from the group consisting of H, (Ci-Cg)alkyl, (€3-Cg)alkenyl, (C3-C8)alkynyl, (C3-C7)cycloalkyl, (C4-C8)cycloalkyl-alkyl, aryl, aryl(Ci-C8)alkyl and (Ci-Cg)alkylene-Z, wherein Z is selected from the group consisting of CORd, COORd, NRdRe, NRdCONReRf, NRdCORe, NRdCOORe and CONRdRc wherein Rd, Re and Rrare each independently selected from the group consisting of H, (Cj-Cg)alkyl and phenyl, or optionally two of Rd, Re and Rrwhen attached to the same nitrogen atom are combined to form a five-or six-membered ring; and wherein Rm is selected from the group consisting of H, (Ci-C8)alkyl, aryl, OH and S02Rn, wherein R" is selected from the group consisting of (C,-C8)alkyl, (CrC8)haloalkyl, aryl(Ci-C8)alkyl, (Cr Cg)heteroalkyl, aryl, heteroaryl, (Ci-Cg)alkoxy, aryloxy, alkylamino, dialkylamino, arylamino, diarylamino, haloalkylamino and di(haloalkyl)amino, and Rm and Rc are optionally combined with the nitrogen atom to which each is attached to form a five- or six-membered ring; HAr is heteroaryl moiety, optionally substituted with from one to three substituents independently selected from the group consisting of halogen, hydroxy, (d-C8)alkyl, aryl(C,-C8)alkyl, (CrC8)alkoxy, (C2-C8)alkenyl, (C2-C8)alkynyl, (C3-C7)cycloalkyl, (C4-C8)cycloalkyl-alkyl, (Ci-Cg)heteroalkyl, (C2-Csjheterocyclyl, aryl, aryloxy, heterosubstituted(C3-C7)cycloalkyl, heteroalkyl substituted (C3-C7)cycloalkyl, (Ci-Cg)haloalkyl, O(Ci-C8)haloalkyl, nitro, cyano, CO2R8, CORg, NR8Rh, S(O)qR8, S02NRgRh, NR^ONRV, NRgCORh, NRgCOORh and CONRgRh, wherein RE, Rh and R* are each independently selected from the group consisting of H and (Ci-C8)alkyl, or optionally two of RE, Rh and R1 when attached to the same nitrogen atom are combined to form a five- or six-membered ring, and the subscript q is an integer of from 0 to 2; each R1 and R3 is a member independently selected from the group consisting of halogen, hydroxy, (C,-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, (C,-C8)alkoxy, (C3-C7)cycloalkyl, (C4-C8)cycloalkyl-alkyl, (C,-C8)haloalkyl, (Ci-C8)heteroalkyl, (C2-C5)heterocyclyl, heterosubstituted(C3-C7)cycloalkyl, heteroalkyl substituted (C3-C7)cycloalkyl, O(Ci-C8)haloalkyl, nitro, cyano, phenyl, O-phenyl, NRj-phenyl, S(O)r-phenyl, CORJ, COORj, NRjRk, S(O)rRj, S02NRJRk, NRJCONRkR', NRjCORk, NRJCOORk and CONRjRk wherein the phenyl ring is optionally substituted and RJ, R and R are each independently selected from the group consisting of H, (Ci-C8)alkyl and (Ci-C8)haloalkyl, or optionally two of Rj, Rk and R1 when attached to the same nitrogen atom are combined to form a five- or six-membered ring, and the subscript r is an integer of from 0 to 2; R2 is a member selected from the group consisting of H, (CpCg^lkyl, (Ci- C8)haloalkyl, aryl(C|-C8)alkyl and (Ci-C4)alkylene-Z, wherein Z is as defined above; the subscript m is an integer of from 0 to 4; the subscript p is an integer of from 0 to 3; and pharmaceutically acceptable salts thereof. 57. A method in accordance with claim 56, wherein said administering is intravenous, transdermal or oral. 58. A method for modulating insulin resistance in a subject, said method comprising administering to said subject a therapeutically effective amount of a compound having the formula: (Figure Remove) wherein X is a member selected from the group consisting of 0, S, SO, SO2 and NR, wherein R is H, (Ci-Cg)alkyl, COR3, COORa and CONRaRbwherein Ra and Rb are each independently selected from the group consisting of H and (CrCg)alkyl; Y is a member selected from the group consisting of CH2ORC, CO2RC, CHO, CONRcRm, CH(=NRC), CH(-NORC) and carboxylic acid surrogates, wherein Rc is a member selected from the group consisting of H, (Ci-Cg)alkyl, (€3-Cg)alkenyl, (C3-C8)alkynyl, (C3-C7)cycloalkyl, (C4-Cg)cycloalkyl-alkyl, aryl, aryl(Ci-Cg)alkyl and (Ci-C8)alkylene-Z, wherein Z is selected from the group consisting of CORd, COORd, NRdRe, NRdCONReRf, NRdCORe, NRdCOORe and CONRdRe wherein Rd, Re and Rf are each independently selected from the group consisting of H, (Ci-Cg)alkyl and phenyl, or optionally two of Rd, Re and Rr when attached to the same nitrogen atom are combined to form a five-or six-membered ring; and wherein Rm is selected from the group consisting of H, (Ci-C8)alkyl, aryl, OH and S02R", wherein R" is selected from the group consisting of (Ci-Cg)alkyl, (C,-C8)haloalkyl, aryl(CrCg)alkyl, (C,-Cg)heteroalkyl, aryl, heteroaryl, (CrCg)alkoxy, aryloxy, alkylamino, dialkylamino, arylamino, diarylamino, haloalkylamino and di(haloalkyl)amino, and Rm and Rc are optionally combined with the nitrogen atom to which each is attached to form a five- or six-membered ring; HAr is heteroaryl moiety, optionally substituted with from one to three substituents independently selected from the group consisting of halogen, hydroxy, (Q-C8)alkyl, aryl(C,-C8)alkyl, (d-Cg)alkoxy, (C2-C8)alkenyl, (C2-C8)alkynyl, (C3-C7)cycloalkyl, (C4-C8)cycloalkyl-alkyl, (Ci-C8)heteroalkyl, (C2-Cjjheterocyclyl, aryl, aryloxy, heterosubstituted(C3-C7)cycloalkyl, heteroalkyl substituted (C3-C7)cycloalkyl, (C,-C8)haloalkyl, O(d-C8)haloalkyl, nitro, cyano, C02R8, CORE, NRgRh, S(O)qRg, SO2NRERh, NR«CONRhRi, NRgCORh, NRgCOORh and CONRgRh, wherein Rg, Rh and R' are each independently selected from the group consisting of H and (Ci-C8)alkyl, or optionally two of Rg, Rh and R' when attached to the same nitrogen atom are combined to form a five- or six-membered ring, and the subscript q is an integer of from 0 to 2; each R1 and R3 is a member independently selected from the group consisting of halogen, hydroxy, (Ci-Cg)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, (C,-C8)alkoxy, (Cj-C7)cycloalkyl, (C4-C8)cycloalkyl-alkyl, (Ci-Cg)haloalkyl, (C,-C8)heteroalkyl, (C12-Cs)heterocyclyl, heterosubstituted(C3-C7)cycloalkyl, heteroalkyl substituted (C3-C7)cycloalkyl, O(Ci-C8)haloalkyl, nitro, cyano, phenyl, O-phenyl, NRj-phenyl, S(O)r-phenyl, CORj, COORJ, NRJRk, S(O)rRj, S02NRjRk, NRJCONRkR', NRJCORk, NRjCOORk and CONRjRk wherein the phenyl ring is optionally substituted and R*, Rk and R1 are each independently selected from the group consisting of H, (C]-C8)alkyl and (Ci-Cg)haloalkyl, or optionally two of R*, Rk and R1 when attached to the same nitrogen atom are combined to form a five- or six-membered ring, and the subscript r is an integer of from 0 to 2; R2 is a member selected from the group consisting of H, (Ci-C8)alkyl, (Ci- C8)haloalkyl, aryl(Ci-Cg)alkyl and (Ci-C^alkylene-Z, wherein Z is as defined above; the subscript m is an integer of from 0 to 4; the subscript p is an integer of from 0 to 3; and pharmaceutically acceptable salts thereof. 59. A method in accordance with claim 58, wherein said administering is intravenous, oral or topical. 60. A method in accordance with claim 58, wherein said compound modulates a condition selected from the group consisting of polycystic ovarian syndrome, Impaired Glucose Tolerance, obesity, gestational diabetes, Syndrome X and atherosclerosis. 61. A method in accordance with claim 58, wherein said compound is administered to a human subject in an amount of from about 1 mg to about 2000 mg per day. 62. A method in accordance with claim 58, wherein said compound is administered to a human subject together with a pharmaceutically acceptable carrier. 63. A method in accordance with claim 58, wherein said compound is administered in combination with a clinically effective agent selected from the group consisting of a sulfonylurea or other insulin secretogogue, a thiazolidinedione, a fibrate, a HMG-CoA reductase inhibitor, a biguanide, a bile acid binding resin, nicotinic acid, an a- glucosidase inhibitor and insulin. 64. A method of alleviating hyperlipidemia in a subject, said method comprising administering to said subject a therapeutically effective amount of a compound having the formula: (Figure Remove) X is a member selected from the group consisting of O, S, SO, SOa and NR, wherein R is H, (CrC8)alkyl, CORa, COORa and CONR"Rb wherein Ra and Rb are each independently selected from the group consisting of H and (Ci-Cg)alkyl; Y is a member selected from the group consisting of Cf^OR0, CO2R°, CHO, CONRcRm, CH(=NRC), CH(=NORC) and carboxylic acid surrogates, wherein Rc is a member selected from the group consisting of H, (Ci-Cg)alkyl, (€3-C8)alkenyl, (C3-C8)alkynyl, (C3-C7)cycloalkyl, (C4-C8)cycloalkyl-alkyl, aryl, aryl(Ci-Cg)alkyl and (CpCg)alkylene-Z, wherein Z is selected from the group consisting of COR'1, COORd, NRdRe, NRdCONReRr, NRdCORe, NRdCOORe and CONRdRc wherein R , Re and Rf are each independently selected from the group consisting of H, (Ci-Cg)alkyl and phenyl, or optionally two of Rd, Re and Rf when attached to the same nitrogen atom are combined to form a five- or six-membered ring; and wherein Rm is selected from the group consisting of H, (Ci-Cg)alkyl, aryl, OH and S02Rn, wherein R" is selected from the group consisting of (C,-C8)alkyl, (Ci-Cg)haloalkyl, aryl(Ci-CB)aIkyl, (Cr Cg)heteroalkyl, aryl, heteroaryl, (Ci-Cg)alkoxy, aryloxy, alkylamino, dialkylamino, arylamino, diarylamino, haloalkylamino and di(haloalkyl)amino, and Rni and Rc are optionally combined with the nitrogen atom to which each is attached to form a five- or six-membered ring; HAr is heteroaryl moiety, optionally substituted with from one to three substituents independently selected from the group consisting of halogen, hydroxy, (Cp C8)alkyl, aryl(Ci-C8)alkyl, (C,-C8)alkoxy, (C2-Cg)alkenyl, (C2-C8)alkynyl, (C3-C7)cycloalkyl, (C4-C8)cycloalkyl-alkyl, (Ci-Cg)heteroalkyl, (C2-C.-Oheterocyclyl, aryl, aryloxy, heterosubstituted(C3-C7)cycloalkyl, heteroalkyl substituted (CrC7)cycloalkyl, (Ci-Cg)haloalkyl, O(Ci-Cg)haloalkyl, nitro, cyano, CO2R8, COR8, NR6Rh, S(O)qRg, SO2NRgRh, NR^ONR^', NRgCORh, NRKCOORh and CONRgRh, wherein Rg, Rh and R1 are each independently selected from the group consisting of H and (Ci-Cg)alkyl, or optionally two of RE, Rh and R' when attached to the same nitrogen atom are combined to form a five- or six-membered ring, and the subscript q is an integer of from 0 to 2; each R1 and R1 is a member independently selected from the group consisting of halogen, hydroxy, (Ci-Cg)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, (Cr C8)alkoxy, (C3-C7)cycloalkyl, (C4-Cg)cycloalkyl-alkyl, (Ci-Cg)haloalkyl, (Cr Cg)heteroalkyl, (C2-C5)heterocyclyl, heterosubstituted(C3-C7)cycloalkyl, heteroalkyl substituted (C3-C7)cycloalkyl, O(Ci-Cg)haloalkyl, nitro, cyano, phenyl, O-phenyl, NRJ-phenyl, S(O)r-phenyl, CORJ, COORj, NRJRk, S(O)rRJ, S02NRjRk, NRjCONRkR', NRjCORk, NRJCOORk and CONRjRk wherein the phenyl ring is optionally substituted and R*, Rk and R1 are each independently selected from the group consisting of H, (Ci-Cg)alkyl and (C]-C8)haloalkyl, or optionally two of R', Rk and R1 when attached to the same nitrogen atom are combined to form a five- or six-membered ring, and the subscript r is an integer of from 0 to 2; R2 is a member selected from the group consisting of H, (Ci-Cg)alkyl, (Ci- Cg)haloalkyl, aryl(C]-Cg)alkyl and (C|-C4)alkylene-Z, wherein Z is as defined above; the subscript m is an integer of from 0 to 4; the subscript p is an integer of from 0 to 3; and pharmaceutically acceptable salts thereof. 65. A method in accordance with claim 64, wherein said compound lowers serum cholesterol levels, serum triglyceride levels, or a combination thereof. 66. A method in accordance with claim 64, wherein said compound is administered to a human subject in an amount of from about 1 mg to about 2000 mg per day. 67. A method of treating hyperuricemia in a subject, said method comprising administering to said subject a therapeutically effective amount of a compound having the formula: (Figure Remove) wherein X is a member selected from the group consisting of O, S, SO, SOa and NR, wherein R is H, (C,-C8)alkyl, COR", COORa and CONRaRb wherein Ra and Rb are each independently selected from the group consisting of H and (Ci-CgJalkyl; Y is a member selected from the group consisting of CHaOR0, COjR0, CHO, CONRcRm, CH(-NRC), CH(=NORC) and carboxylic acid surrogates, wherein Rc is a member selected from the group consisting of H, (Ci-Cg)alkyl, (€3-Cg)alkenyl, (C3-C8)alkynyl, (C3-C7)cycloalkyl, (C4-C8)cycloalkyl-alkyl, aryl, aryl(Ci-Q()alkyl and (Ci-Cg)alkylene-Z, wherein Z is selected from the group consisting of CORd, COORd, NRdRe, NRdCONReRf, NRdCORc, NRdCOORe and CONRdRc wherein Rd, Rc and Rf are each independently selected from the group consisting of H, (Ci-Cg)alkyl and phenyl, or optionally two of Rd, Re and R when attached to the same nitrogen atom are combined to form a five-or six-membered ring; and wherein Rm is selected from the group consisting of H, (Ci-C8)alkyl, aryl, OH and S02Rn, wherein Rn is selected from the group consisting of (C)-Q)alkyl, (CrC8)haloalkyl, aryl(Ci-C8)alkyl, (C,- Cs)heteroalkyl, aryl, heteroaryl, (C|-C8)alkoxy, aryloxy, alkylamino, dialkylamino, arylamino, diarylamino, haloalkylamino and di(haloalkyl)amino, and Rm and Rc are optionally combined with the nitrogen atom to which each is attached to form a five- or six-membered ring; HAr is heteroaryl moiety, optionally substituted with from one to three substituents independently selected from the group consisting of halogen, hydroxy, (C|-Cg)alkyl, aryl(C,-C8)alkyl, (C,-C8)alkoxy, (C2-C8)alkenyl, (C2-C8)alkynyl, (C3-C7)cycloalkyl, (C4-C8)cycloalkyl-alkyl, (C,-C8)heteroalkyl, (C2-C5)heterocyclyl, aryl, aryloxy, heterosubstituted(C3-C7)cycloalkyl, heteroalkyl substituted (C3-C7)cycloalkyl, (d-C8)haloalkyl, O(Ci-C8)haloalkyl, nitro, cyano, CO2R8, CORg, NR8Rh, S(O)qRg, SO2NRgRh, NR^ONR11^, NRgCORh, NRgCOORh and CONReRh, wherein Rg, Rh and R1 are each independently selected from the group consisting of H and (Ci-Cg^lkyl, or optionally two of R8, Rh and R1 when attached to the same nitrogen atom are combined to form a five- or six-membered ring, and the subscript q is an integer of from 0 to 2; each R1 and R3 is a member independently selected from the group consisting of halogen, hydroxy, (CrC8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, (Ci-C8)alkoxy, (C3-C7)cycloalkyl, (C4-C8)cycloalkyl-alkyl, (CrC8)haloalkyl, (C,-C8)heteroalkyl, (C2-C.s)heterocyclyl, heterosubstituted(C3-C?)cycloalkyl, heteroalkyl substituted (C3-C7)cycloalkyl, O(Ci-C8)haloalkyl, nitro, cyano, phenyl, O-phenyl, NRJ-phenyl, S(O)r-phenyl, CORJ, COORj, NRjRk, S(O)rRj, SO2NRJRk, NRjCONRkR', NRjCORk, NRJCOORk and CONRjRk wherein the phenyl ring is optionally substituted and RJ, Rk and R1 are each independently selected from the group consisting of H, (Ci-Cs)alkyl and (Ci-Cg)haloalkyl, or optionally two of Rj, Rk and R1 when attached to the same nitrogen atom are combined to form a five- or six-membered ring, and the subscript r is an integer of from 0 to 2; R2 is a member selected from the group consisting of H, (Ci-C8)alkyl, (Ci- C8)haloalkyl, aryl(C|-C8)alkyl and (Ci-C-Oalkylene-Z, wherein Z is as defined above; the subscript m is an integer of from 0 to 4; the subscript p is an integer of from 0 to 3; and pharmaceutically acceptable salts thereof. 68. A method in accordance with claim 67, wherein said compound is administered to a human subject in an amount of from about 1 mg to about 2000 mg per day. 69. A method in accordance with claim 67, wherein said compound is administered to a human subject together with a pharmaceutically acceptable carrier. 70. A method in accordance with claim 67, wherein said administering is intravenous, oral or topical. 71. A prodrug agent having a formula selected from the group consisting of: (Figure Remove) X is a member selected from the group consisting of 0, S, SO, SOz and NR, wherein R is H, (C,-CB)alkyl, COR", COORa and CONRaRb wherein Ra and Rb are each independently selected from the group consisting of H and (Ci-Cg)alkyl; Y is a member selected from the group consisting of CC^R", wherein R" is selected from the group consisting of alkyl, heteroalkyl, aryl, heteroaryl, phenyl-lower alkyl, benzamido-lower alkyl, di-lower alkylamino-lower alkyl, ureido-lower alkyl, N'-lower alkyl-ureido-lower alkyl, carbamoyl-lower alkyl, halophenoxy substituted lower alkyl and carbamoyl substituted phenyl; HAr is heteroaryl moiety, optionally substituted with from one to three substituents independently selected from the group consisting of halogen, hydroxy, (d-C8)alkyl, aryl(C,-C8)alkyl, (C,-C8)alkoxy, (C2-C8)alkenyl, (C2-C8)alkvnyl, (C3-C7)cycloalkyl, (Q-C8)cycloalkyl-alkyl, (Ci-C8)heteroalkyl, (C2-Cs)heterocyclyl, aryl, aryloxy, heterosubstituted(C3-C7)cycloalkyl, heteroalkyl substituted (C3-C7)cycloalkyl, (Ci-Cg)haloalkyl, 0(C|-Cg)haloalkyl, nitro, cyano, C02Rg, COR8, NRERh, S(0) selected from the group consisting of H and (Ci-Cg)alkyl, or optionally two of Rg, Rh and R1 when attached to the same nitrogen atom are combined to form a five- or six-membered ring, and the subscript q is an integer of from 0 to 2; each R1 and R3 is a member independently selected from the group consisting of halogen, hydroxy, (CrC8)alkyl, (C2-C8)alkenyl, (C2-Cg)alkynyl, (C,-C8)alkoxy, (C3-C7)cycloalkyl, (C4-C8)cycloalkyl-alkyl, (C,-C8)haloalkyl, (Cr C8)heteroalkyl, (C2-C5)heterocyclyl, heterosubstituted(C3-C7)cycloalkyl, heteroalkyl substituted (C3-C7)cycloalkyl, O(C|-Cg)haloalkyl, nitro, cyano, phenyl, 0-phenyl, NRJ-phenyl, S(O)r-phenyl, CORj, COORj, NRjRk, S(0)rRj, S02NRjRk, NRjCONRkR1, NRjCORk, NRjCOORk and CONRjRk wherein the phenyl ring is optionally substituted and RJ, Rk and R1 are each independently selected from the group consisting of H, (Ci-Cg)alkyl and (Ci-Cg)haloalkyl, or optionally two of R*, Rk and R1 when attached to the same nitrogen atom are combined to form a five- or six-membered ring, and the subscript r is an integer of from 0 to 2; R2 is a member selected from the group consisting of H, (Ci-Cg)alkyl, (Ci- Cg)haloalkyl-, aryl(Ci-Cg)alkyl and (Ci-C4)alkylene-Z, wherein Z is as defined above; the subscript m is an integer of from 0 to 4; the subscript p is an integer of from 0 to 3; and phannaceutically acceptable salts thereof. 72. A prodrug agent in accordance with claim 71, wherein R" is selected from the group consisting of (i) (Ci-C5)alkyl, (C3-Cg)cycloalkyl, (C2-C5)alkenyl and (C2-C^alkynyl, wherein the groups are optionally substituted with one or more halogen atoms; (ii) phenyl, naphthyl and pyridyl, wherein the groups are optionally substituted with one or more substituents selected from the group consisting of halo, (Ci-C^alkyl, (Ci-C4)alkoxy, -N02, -S(0)m,(C,-C5alkyl), -OH, -NR3aR4a, -C02R5a, -CONR3aR4a, -NR3aCOR4a, -NR3aCONR3aR4a and -CviFWi; (iii) -(CHR3a)R4a; -R5aOR3a; -R5aO2CR6aNR3aR4a; -R8aCOR6a; -R7aNR3aCOR4a; -R7aNR3aR4a; -(CH2)0,CH(R3a)(CH2)q,O2CR9a; -(CH2)01CH(R3a)(CH2)q,NR4aCOR9a;-(CH2)01CH(R3a)(CH2)q,NR4aCONR3aR4a; -(CH2)o,CH(R3a)(CH2)qlNR4aCOOR10a;-(CH2)01CH(R3a)(CH2)qlNR4aS02Rlla; -(CHR3a)piC02R12a; -(CHR3a)p,NR3aR4a; -(CHR3a)slCONR13aR14a, wherein the subscripts ml, ol, ql, si, tl, ul, vl and wl are integers as follows: ml is 0 to 2; ol and ql are 0 to 5; pi is 1 to 5; si is 1 to 3; tl is 1 to 5; ul is 0 to 1; vl is 1 to 3; and wl is 1 to (2vl + 1) and wherein R3a and R4a are independently H, CrC5 alkyl, phenyl or benzyl, R5a is H, Ci-Cs alkyl or NR3aR4a, R6a is phenyl, naphthyl, pyridyl, imidazolyl, indoxyl, indolizinyl, oxazolyl, thiazolyl, thienyl, pyrimidyl, or 1-pyrazolyl optionally substituted with one or more substituents selected from the group consisting of halo, Ci-C4 alkyl, Ci-C4 alkoxy, -N02, -S(O)mi(Ci-C5alkyl), -OH, ~NR3aR4a, -CO2Ria, -CONR3aR4a, -NR3aCOR4a, ~NR3aCONR3aR4a and -CviFwi, R7a is a CrC8 saturated or unsaturated, straight-chain, branched or cyclic alkylene or alkylidene group optionally substituted with one or more groups selected from halo, hydroxyl, thiol, amino, monoalkyl amino, dialkyl amino, acylamino, carboxyl, alkylcarboxyl, acyl, aryl, aroyl, aralkyl, cyano, nitro, alkoxy, alkenyloxy, alkylcarbonyloxy and arylcarbonyloxy, R8a is a Ci-Cs straight-chain or branched alkylene or alkylidene optionally substituted with one or more groups selected from amino, monoalkyl amino, dialkyl amino, acylamino, hydroxyl, thiol, methylthiol, carboxyl and phenyl, R9a and R10a are independently H, Ci-Cs alkyl, optionally substituted with one or more groups consisting of C|-C -S(O)mi(Ci-C5alkyl), -OH, -NR3aR4a, -CO2R5a, -CONR3aR4a, -NR3aCOR4a, -NR3aCONR3aR4a, -CH2NR3aR4a, OOCR18" and -Cv,Fwl; and wherein R13a and R14a are included as -(CHR3a)CONR!3aRl4a wherein NR13aR14a is R15a is CV|FW) or C|-Cs alkyl, wherein C|-Cs alkyl is optionally substituted with the following substituents: Ci-C? alkoxy; phenyl, optionally substituted with one or more substituents selected from the group consisting of halo, C|-C4 alkyl, Ci-C4 alkoxy, -NOa, -S(O)mi(C|-C5alkyl), -OH, -NRJaR4a, -CO2R5a, -CONR3aR4a, -NR3aCOR4a, -NR3aCONR3aR4a and -CviFWi; ben?.yl, optionally substituted with one or more substituents selected from the group consisting of halo, CrC« alkyl, CrC4 alkoxy, -N02, -S(0)mi(C|-C5alkyl), -OH, -NR3aR4a, -C02R5a, -CONR3aR4a, -NRJ*COR4a, -NR3aCONR3aR4a and -CviFwi, R16a is H, Ci-C5 alkyl or benzyl, R17a is CrC5 alkyl, C3-C8 cyclic alkyl, phenyl or benzyl, Rl8a is H, alkyl, aryl, aralkyl or cycloalkyl, where the group is optionally substituted with one or more substituents selected from the group consisting of halo, Ci-C4 alkyl, CrC4 alkoxy, -N02, -S(O)mi(Ci-Cjalkyl), -OH, -NR3aR4a, -CO2R5a, -CONR3aR4a, -NR3aCOR4a, -NR3aCONR3aR4a and

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