Title of Invention

4-AMINO-5-PHENYL-7-CYCLOBUTYL-PYRROLO (2,3-D) PYRIMIDINE DERIVATIVES

Abstract

The invention relates to new 4-amino-5-phenyl-7-Cyclobutyl-pyrrolo[2.3-d]pyrimidine derivatives, processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, the use thereof - alone or in combination with one or more other pharmaceutically active compounds - for the treatment of a disease, especially a proliferative disease, such as a tumour disease, a method for the treatment of such diseases in mammals, especially in humans, and the use of such a compound - alone or in combination with one or more other pharmaceutically active compounds - for the preparation of a pharmaceutical composition (medicament) for the treatment especially of a proliferative disease, such as a tumour.

Full Text

4-amino-5-phenyl-7-cyclobutyl-pvrrolo[2,3-d]pyrimidine derivatives The invention relates to new 4-amino-5-phenyl-7-cyclobutyl-pyrrolo[2,3-d]pyrimidine derivatives, processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, the use thereof - alone or in combination with one or more other pharmaceutically active compounds - for the treatment of a disease, especially a proliferative disease, such as a tumour disease, a method for the treatment of such diseases in mammals, especially in humans, and the use of such a compound - alone or in combination with one or more other pharmaceutically active compounds - for the preparation of a pharmaceutical composition (medicament) for the treatment especially of a proliferative disease, such as a tumour. WO 98/41525 published on 24 September 1998 discloses substituted 4-amino-7H-pyrrolo[2,3-d]pyrimidines having therapeutic activity as protein tyrosine kinase inhibitors. Surprisingly, it has now been found that the compounds of formula I, described below, are potent inhibitors of the tyrosine kinase activity of the Insulin-like growth factor I receptor (IGF-IR) and inhibit IGF-IR-dependent cell proliferation. The pesence of the substituents, preferably benzyloxy substituents, at position 3 of the phenyl group of the 4-amino-5-phenyl-7-cyclobutyl-pyrrolo[2,3-d]pyrimidine scaffold together with the presence of the substitutent R2 as defined herein below is crucial for the efficacy and/or the specificity of the compounds of the present invention as IGF-IR tyrosine kinase inhibitors and their potential and/or selectivity to inhibit IGF-IR-dependent cell proliferation. The compounds of formula I permit, for example, an unexpected new therapeutic approach, especially for diseases in the treatment of which, and also for the prevention of which, an inhibition of the IGF-IR tyrosine kinase and/or of the IGF-IR-dependent cell proliferation shows beneficial effects. Such diseases include proliferative diseases, such as tumours, like for example breast, renal, prostate, colorectal, thyroid, ovarian, pancreas, neuronal, lung, uterine and gastro-intestinal tumours as well as osteosarcomas and melanomas. The invention relates to compounds of formula I wherein n is from 0 to 4, R1is hydrogen, unsubstituted or substituted lower alky! or halogen, R2 is lower alkyl substituted by hydroxy, unsubstituted, mono- or disubstituted amino or by a heterocyclic radical; a radical R5-(C=Y)-Z-, wherein R5 is unsubstituted or substituted lower alkyl. unsubstituted. mono- or disubstituted amino, a heterocyclic radical, or free or etherified hydroxy, Y is oxygen, sulfur or imino, and Z is either not present, lower alkyl or amino-lower alkyl; or a radical R6-suifonylamino-lower alkyl, wherein R6 is unsubstituted or substituted lower alkyl, unsubstituted. mono- or disubstituted amino or phenyl optionally substituted by lower alkyl, lower alkoxy or nitro, with the proviso that R2 is not carboxy, lower alkoxycar-bonyl or lower alkyl substituted by hydroxy if n is 0, R1is hydrogen, R4 is benzyl and X is -O-. R3 is lower alkyl. hydroxy-, amino- or halogen-substituted lower alkyl. hydroxy, cyano. lower alkoxy. lower aikanoyl. lower alkanoyloxy. amino, mono- or di-lower alkylamino, lower alka-noylamino. carboxy. lower alkoxycarbonyl or halogen, wherein the R3 substituents can be selected independently of one another if n>1. R4 is a radical R7-CR8(R9)-. wherein R7 is cyclobutyl, cyclopentyl, cyclohexyl, phenyl, furyl. pyrrolyl, thienyl or pyridyl, said R7 substitutents being optionally substituted by one or more radicals selected from lower alkyl and halogen, and R6 and R9 are independently of each other hydrogen, lower alkyl or halogen, and X is selected from -O-, -NH- and -S-, or a salt thereof. The general terms used hereinbefore and hereinafter preferably have within the context of this disclosure the following meanings, unless otherwise indicated: Where compounds of formula I are mentioned, this is meant to include also the tautomers and N-oxides of the compounds of formula I. Where the plural form is used for compounds, salts, and the like, this is taken to mean also a single compound, salt, or the like. Asymmetric carbon atoms of a compound of formula I that are optionally present may exist in the (R). (S) or {R,S) configuration, preferably in the (R) or (S) configuration. Substituents at a double bond or a ring may be present in cis- (= Z-) or trans (= E-) form. The compounds may thus be present as mixtures of isomers or as pure isomers, preferably as enantiomer-pure diastereomers. The prefix -lower- denotes a radical having up to and including a maximum of 7, especially up to and including a maximum of 4 carbon atoms, the radicals in question being either un-branched or branched with single or multiple branching. Lower alkyl is, for example, methyl, ethyl, n-propyl. isopropyl. n-butyl, isobutyl. sec-butyl, tert-butyl, n-pentyl. isopentyl. neopentyl, n-hexyl or n-heptyl. Lower alkylene is. for example, methylene (-CH2-). ethylene (-CH2-CH2-), propylene (-CH2-CH2-CH2-) or tetramethylene (-CH2-CH2-CH2-CH2-)- C1-C6alkyI or C1-C5alkyI are either unbranched or branched (with single or multiple branching) alkyl radicals having from 1 to 6 or from 1 to 5 carbon atoms, respectively, and include methyl, ethyl, n-propyl. 2-propyl, n-butyl, sec-butyl, t-butyl, and the like. In R2 being lower alkyl substituted by unsubstituted. mono- or disubstituted amino or by a heterocyclic radical, lower alkyl is preferably methyl. Lower alkyl R5 is preferably methyl, isopropyl or tert-butyl. Amino-lower alkyl Z is preferably aminomethyL In R6-sulfonylamino-lower alkyl, lower alkyl is preferably methyl. Lower alkyl R6 is preferably methyl, ethyl or isopropyl. Substituted lower alkyl is lower alkyl as defined above wheR6one or more, preferably one. substituents may be present, such as amino. N-lower alkylamino, N.N-di-lower alkylamino, N-lower alkanoylamino, N.N-di-lower alkanoylamino. hydroxy, lower aikoxy, lower alkoxy-lower aikoxy. lower alkanoyl. lower alkanoyloxy, cyano, nitro, carboxy. lower alkoxycarbonyj. carbamoyl, amidino, guanidino. ureido. mercapto. lower alkylthio, halogen or a heterocyclic radical. Substituted lower alkyl R5 is preferably lower alkyl substituted by lower aikoxy, lower alkoxy-lower aikoxy or most preferably by a heterocyclic radical. Halogen is primarily fluorine, chlorine, bromine, or iodine, especially fluorine, chlorine, or bromine. Mono- or disubstituted amino is amino substituted by one or two radicals selected independently of one another from e.g. unsubstituted or substituted lower alkyl; phenyl or phenyl-lower alkyl wherein the phenyl radical is optionally substituted by e.g. unsubstituted or substituted lower alkyl. amino, N-lower alkylamino, N,N-di-lower alkylamino, N-lower alkanoylamino, N,N-di-lower alkanoylamino, hydroxy, lower aikoxy, lower alkoxy-lower aikoxy. lower alkanoyl, lower alkanoyloxy. cyano, nitro, carboxy, lower alkoxycarbonyl, carbamoyl, amidino. guanidino, ureido. mercapto. lower alkylthio or halogen; adamantanyl; and a heterocyclic radical. In R2 being lower alkyl substituted by mono- or disubstituted amino, mono- or disubstituted amino preferably represents N-lower alkylamino or N,N-di-lower alkylamino, respectively. Mono- or disubstituted amino R5 is preferably N-lower alkylamino or N,N-di-lower alkylamino. respectively, wherein the lower alkyl moiety is optionally substituted by phenyl, lower alkyl-phenyl, lower alkoxy-phenyl. morpholinyl or N,N-di-lower alkylamino. Mono- or disubstituted amino R6 is preferably N,N-di-lower alkylamino. A heterocyclic radical contains especially up to 20 carbon atoms and is preferably a saturated or unsaturated monocyclic radical having from 4 or 8 ring members and from 1 to 3 heteroatoms which arepreferably selected from nitrogen, oxygen and sulfur, or a bi- or tricyclic radical wherein, for example, one or two benzene radicals areannellated (fused) to the mentioned monocyclic radical. Preferred above all, the heterocyclic radical contains at least one nitrogen ring atom whereby the binding of the heterocyclic radical to the radical of the molecule of formula I occurs via a nitrogen ring atom. The heterocyclic radical is optionally substituted by one or more, preferably by one or two. radicals such as e.g. unsubstituted or substituted lower alkyl, amino, N-lower alkylamino, N,N-di-lower alkylamino, N-lower alka-noylamino, N,N-di-lower alkanoylamino, hydroxy, lower alkoxy, lower alkoxy-lower alkoxy, lower alkanoyl, lower alkanoyloxy. cyano. nitro, carboxy. lower alkoxycarbonyl. carbamoyl, amidino. guanidino. ureido. mercapto. lower alkylthio, halogen, phenyl or pyridyl. Most preferably a heterocyclic radical is azetidinyl, pyrrolidinyl. piperidyl, azepanyl, piperaz-inyl, tetrahydropyranyl. morpholinyl or thiomorpholinyl, wherein said radicals areoptionally substituted by one or more, preferably one or two. radicals selected independently of one another from the group consisting of lower alkyl, hydroxy-lower alkyl. free or etherified hydroxy, lower alkoxycarbonyl, carbamoyl, phenyl and pyridyl and the binding of the heterocyclic radical to the radical of the molecule of formula I occurs via a nitrogen ring atom. In R2 being lower alkyl substituted by a heterocyclic radical, the heterocyclic radical preferably represents azetidinyl. pyrrolidinyl, di-lower alkyl-pyrrolidinyl, aminocarbonyl-pyrrolidinyl. piperidyl. hydroxy-piperidyl, aminocarbonyl-piperidyl. azepanyl. lower alkyl-piperazinyl. lower alkoxycarbonyl-piperazinyl. phenyl-piperazinyl. pyridyl-piperazinyl, morpholinyl, di-lower alkyl-morpholinyl or thiomorpholinyl. In R5 being lower alkyl substituted by a heterocyclic radical, the heterocyclic radical preferably represents piperidyl, lower alkyl-piperazinyl or morpholinyl. A heterocyclic radical R5 is preferably pyrrolidinyl, piperidyl. lower alkyl-piperazinyl or morpholinyl. Etherified hydroxy is, for example, alkoxy, especially lower alkoxy. The lower alkyl moiety of lower alkoxy is optionally substituted by one or more, preferably one, radicals such as e.g. amino, N-lower alkylamino, N.N-di-lower alkylamino. N-lower alkanoylamino, N,N-di-lower al- kanoylamino, hydroxy, lower alkoxy, lower alkoxy-lower alkoxy, lower alkanoyl, lower alka-noyloxy, cyano. nitro. carboxy, lower alkoxycarbonyl, carbamoyl, amidino. guanidino, ureido, mercapto, lower alkylthio, halogen or a heterocyclic radical. Elherified hydroxy R5 is preferably lower alkoxy wherein the lower alkyl moiety is optionally substituted by lower alkoxy. N.N-di-lower alkylamino, lower alkyl-piperazinyl or morpholinyl. n is preferably 0. R1preferably represents hydrogen, lower alkyl or halogen, most preferably hydrogen or lower alkyl. R4 is preferably benzyl. X is preferably -O-. Y is preferably oxygen. Salts areespecially the pharmaceutically acceptable salts of compounds of formula I (or an N-oxide thereof). Such salts areformed, for example, as acid addition salts, preferably with organic or inorganic acids, from compounds of formula I (or an N-oxide thereof) with a basic nitrogen atom, especially the pharmaceutically acceptable salts. In the presence of negatively charged radicals, such as carboxy or sulfo, salts may also be formed with bases, e.g. metal or ammonium salts, such as alkali metal or alkaline earth metal salts, or ammonium salts with ammonia or suitable organic amines, such as tertiary monoamines. In the presence of a basic group and an acid group in the same molecule, a compound of formula I (or an N-oxide thereof) may also form internal salts. For isolation or purification purposes it is also possible to use pharmaceutically unacceptable salts, for example picrates or perchlorates. Only the pharmaceutically acceptable salts or free compounds (if the occasion arises, in the form of pharmaceutical compositions) attain therapeutic use, and these aretherefoR6preferred. In view of the close relationship between the novel compounds in free form and in the form of their salts, including those salts that can be used as intermediates, for example in the purification or identification of the novel compounds, hereinbefoR6and hereinafter any reference to the free compounds is to be understood as referring also to the corresponding salts, as appropriate and expedient. The compounds of formula I have valuable pharmacological properties, as described hereinbefoR6and hereinafter. The efficacy of the compounds of the invention as inhibitors of IGF-IR tyrosine kinase activity can be demonstrated using a cellular -CaptuR6ELISA-. In this assay the activity of the compounds of the invention against Insulin-like growth factor I (IGF-I) induced autophosphoryla-tion of the IGF-IR is determined. The assay is conducted as follows: For the assay NIH-3T3 mouse fibroblasts transfected with human IGF-IR cDNA (complete human IGF-IR cDNA: GenBank Ace. No. NM_000875). prepared as described in Kato et al.. J. Biol. Chem. 268, 2655-61.1993. areused. The cells which overexpress human IGF-IR arecultured in Dulbecco*s minimal essential (DMEM) medium, containing 10 % Fetal Calf Serum (FCS). For the assay 5,000 cells/well areplated on day 1 on 96-well plates (Costar #3595) in normal growth medium and incubated for 2 days at 37**C in a standard CO2 cell incubator. The density of the cells does not exceed 70-80 % at day 3. On day 3 the medium is discarded and the cells areincubated for 24 h in minimal medium (DMEM. containing 0.5 % FCS). Compounds of formula I [starting from 10 mM dimethyl sulfoxide (DMSO) stock solutions] areadded to produce final concentrations of 0.01, 0.03, 0.1. 0.3,1. 3 and 10 |iM to determine the IC50 value. The cells areincubated for 90 min in the presence of a compound of formula I. Thereafter the cells arestimulated with 50 |il IGF-I (final concentration of IGF-I in the well = 10 ng/ml; IGF-I is obtained from Sigma; Product Code: I 3769) and incubated for 10min at 37oC. The medium is discarded and the cells arewashed twice with PBS/0 (=Phosphate-Buffered Saline without CaCl2) and lysed for 15 min on ice with 50µl/well RIPA-buffer [50 mM Tris'HCI, pH=7.2,120 mM NaCI. 1 mM EDTA, 6 mM EGTA, 1% NP-40, 20 mM NaF. 1 mM benzamidine. 15 mM sodium pyrophosphate. 1 mM Phenyl methyl sulphonyl fluoride (PMSF) and 0.5 mM Na3VO4] and shaken for 10 min using a 96-well plate shaker (=cellular extracts). Packard HTRF-96 black plates arecoated with 50 µl IGF-IR monoclonal Antibody (mAB) (Santa Cruz; Cat. No.: SC-462) in a concentration of 5 µg/ml at 4°C overnight. The plates arewashed twice with 0.05% (v/v) Tween-20 in Phosphate-Buffered Saline (PBS) and once with nanopureH2O. Blocking is done for 2 h at room temperatuR6(RT) with 3% Bovine Serum Albumin (BSA) in TBS-T buffer (20 mM Tris-HCI. pH=7.6,137 mM NaCl, 0.05 % Tween-20). After blocking, the plates arewashed once with nanopureH2O. Cellular extracts (40 µl/well) arepipetted onto the precoated Packard plates, together with 40 µl of the anti-phosphotyrosine mouse mAB PY-20 conjugated with Alkaline Phosphatase (AP) (1:1000 diluted in RIPA buffer; the antibody is obtained from Transduction Labs; Cat. No.:P11120). After incubating the extracts and the secondary antibody for 2 h at 4 °C . the extracts arediscarded, the plates arewashed twice with 0.05% (v/v) Tween-20 in PBS and once with nanopurewater. 90 µl/well AP substrate (CDP-Star; obtained from Tropix; Cat. No.: MS100RY) arethen added and the plates areincubated for 45 min at RT in the dark, followed by measuring AP activity in a Packard Top Count Microplate Scintillation Counter. The IC50 values for the compounds of formula I arecalculated via linear regression analysis using the GraphPad In-stat program (GraphPad Software. USA). IC50 values in the range of 5 nM to 1 jiM. especially in the range of 5 nM to 300 nM arefound. In vivo activity in the nude mouse xenotransplant model: female BALB/c nude mice (8-12 weeks old, Novartis Animal Farm. Sissein, Switzeriand) arekept under sterile conditions with water and feed ad libitum. Tumours areinduced by subcutaneous injection of tumour cells (human epithelial cell line A-431; American Type CultuR6Collection (ATCC). Rockville, MD. USA. Catalogue Number ATCC CRL 1555; cell line from an 85-year-old woman; epidermoid carcinoma cell line) into carrier mice. The resulting tumours pass through at least three consecutive transplantations befoR6the start of treatment. Tumour fragments (about 25 mg) areimplanted subcutaneously in the left flank of the animals using a 13-gauge trocar needle under Forene anaesthesia (Abbott, Switzeriand). Treatment with the test compound is started as soon as the tumour has reached a mean volume of 100 mm3. Tumour growth is meas- ured two to three times a week and 24 hours after the last treatment by determining the length of two perpendicular axes. The tumour volumes arecalculated in accordance with published methods (see Evans et a!., Brit. J. Cancer 45, 466-8,1982). The anti-tumour efficacy is determined as the mean increase in tumour volume of the treated animals divided by the mean increase in tumour volume of the untreated animals (controls) and. after multiplication by 100, is expressed as T/C%. Tumour regression (given in %) is reported as the smallest mean tumour volume in relation to the mean tumour volume at the start of treatment. The test compound is administered daily by gavage. As an alternative to cell line A-431, other cell lines may also be used in the same manner, for example: - the MCF-7 breast adenocarcinoma cell line (ATCC No. HTB 22; see also J. Natl. Cancer Inst. (Bethesda) 51, 1409-16. 1973); and - the DU145 prostate carcinoma cell line DU 145 (ATCC No. HTB 81; see also Cancer Res. 37.4049-58.1978). On the basis of these studies, a compound of formula I according to the invention shows therapeutic efficacy especially against proliferative diseases responsive to an inhibition of the IGF-IR tyrosine kinase. In general, the invention relates also to the use of a compound of formula I for the inhibition of the IGF-IR tyrosine kinase. In addition to the inhibition of the IGF-IR tyrosine kinase, the compounds of formula I also inhibit the tyrosine kinase activity of the receptor tyrosine kinase Flt-3. The compounds of formula I aretherefoR6also useful for the treatment of proliferative diseases, especially tumour diseases, responsive to an inhibition of the Flt-3 tyrosine kinase receptor. Such tumour diseases include e.g. leukemias and myelodysplastic syndrome. Aben'ant expression of the Flt-3 gene has been documented in both adult and childhood leukemias including acute myeloid leukemia (AML). AML with trilineage myelodysplasia (AMUTMOS), acute lymphoblastic leukemia (ALL), and myelodysplastic syndrome (MDS). The compounds of formula I aretherefoR6suitable for the treatment of these diseases, especially for the treatment of AML since activating mutations of the Flt-3 receptor have been found in about 35% of patients with AML, and areassociated with a poor prognosis. The Flt-3 inhibitory activity of a compound of formula I can be shown in a tyrosine kinase inhibition assay using the cytoplasmic kinase domain of Flt-3. The assay is performed as follows: The baculovirus donor vector pFbacGd (GIBCO) is used to generate a recombinant baculovirus that expresses the amino acid region amino acids 563-993 of the intra-cytoplasmic kinase domain of human Flt-3. The coding sequence for the cytoplasmic domain of Flt-3 is amplified by PCR from human c-DNA libraries (Clontech). The amplified DNA fragments and the pFbacGOl vector aremade compatible for ligation by digestion with BamHI and Hindlll. Ligation of these DNA fragments results in the baculovirus donor plas-mid Flt-3(1.1). The production of the viruses, the expression of proteins in Sf9 cells and the purification of the GST-fused proteins areperformed as follows: Production of virus: Transfer vector (pFbacGO!-Flt-3) containing the Flt-3 kinase domain is transfected into the DHIOBac cell line (GIBCO) and the cells areplated on selective agar plates. Colonies without insertion of the fusion sequence into the viral genome (carried by the bacteria) areblue. Single white colonies arepicked and viral DNA (bacmid) is isolated from the bacteria by standard plasmid purification procedures. Sf9 or Sf21 cells (American Type CultuR6Collection) arethen transfected in 25 cm^ flasks with the viral DNA using Cellfectin reagent. Determination of small scale protein expression in Sf9 cells: Virus containing media is collected from the transfected cell cultuR6and used for infection to increase its titer. Virus containing media obtained after two rounds of infection is used for large-scale protein expression. For large-scale protein expression 100 cm2 round tissue cultuR6plates areseeded with 5x107 cells/plate and infected with 1 mL of virus-containing media (approx. 5 MOIs). After 3 days the cells arescraped off the plate and centrifuged at 500 rpm for 5 min. Cell pellets from 10-20,100 cm2 plates, areresuspended in 50 mL of ice-cold lysis buffer (25 mMTris-HCI, pH 7.5. 2 mM EDTA, 1% NP-40,1 mM DTT, 1 mM PMSF). The cells arestin-ed on ice for 15 min and then centrifuged at 5000 rpms for 20 min. Purification of GST-tagged proteins: The centrifuged cell lysate is loaded onto a 2 mL glu-tathione-sepharose column (Pharmacia) and washed three times with 10 mL of 25 mM Tris-HCI. pH 7.5, 2 mM EDTA. 1 mM DTT. 200 mM NaCI. The GST-tagged protein is then eluted by 10 applications (1 mL each) of 25 mM Tris-HCI. pH 7.5. 10 mM reduced-glutathione, 100 mM NaCI. 1 mM DTT. 10 % Glycerol and stored at -70oC. MeasuR6of enzyme activity: Tyrosine protein kinase assays with purified GST-Flt-3 arecarried out in a final volume of 30 µL containing 200-1800 ng of enzyme protein (depending on the specific activity). 20 mM Tris-HCI. pH 7.6, 3 mM MnCb, 3 mM MgCI2, 1 mM DTT, 10µM Na3VO4. 3µg/mL poly(Glu,Tyr) 4:1.1 % DMSO, 8.0 nM ATP and 0.1 µCi [Y33 P] ATP. The activity is assayed in the presence or absence of inhibitors, by measuring the incorporation of 33P from [y33P] ATP into the poly(Glu Jyr) substrate. The assay (30 µL) is carried out in 96-well plates at ambient temperatuR6for 20 min under conditions described below and terminated by the addition of 20µL of 125 mM EDTA. Subsequently. 40µL of the reaction mixtuR6 is transferred onto Immobilon-PVDF membrane (Millipore. Bedford, MA, USA) previously soaked for 5 min with methanol, rinsed with water, then soaked for 5 min with 0.5 % H3PO4 and mounted on vacuum manifold with disconnected vacuum source. After spotting all samples, vacuum is connected and each well rinsed with 200 µL 0.5 % H3PO4. Membranes areremoved and washed 4 x on a shaker with 1.0 % H3PO4, once with ethanol. Membranes arecounted after drying at ambient temperature, mounting in Packard Top-Count 96-well frame, and addition of 10 µL/well of Microscint TM (Packard). IC50 values arecalculated by linear regression analysis of the percentage inhibition of each compound in duplicate, at four concentrations (usually 0.01, 0.1, 1 and 10µM). One unit of protein kinase activity is defined as 1 nmole of 33P ATP transferred from [y33P] ATP to the substrate protein per minute per mg of protein at 37 oC. In addition to the diseases mentioned above, the compounds of formula 1 can further be used in the treatment of obesity and arealso suitable for the treatment of ischemic retinopathies, such as e.g. diabetic retinopathy and retinopathy of prematurity (ROP). The effectiveness of the compounds of formula I in these diseases can be shown by using in vitro- or in wVo-tests known in the art. Compounds of formula I arealso useful for preventing or combating graft vessel diseases, e,g. alio- or xenotransplant vasculopathies. e.g. graft vessel atherosclerosis or chronic graft rejection, e.g. in a transplant of organ, tissue or cells, e.g. heart, lung, combined heart-lung, liver, kidney or pancreatic transplants (e.g. pancreatic islet cells), or for preventing or treating vein graft stenosis, restenosis and/or vascular occlusion following vascular injury, e.g. caused by catherization procedures or vascular scraping procedures such as percutaneous transluminal angioplasty, laser treatment or other invasive procedures which disrupt the integrity of the vascular intima or endothelium. With the groups of preferred compounds of formula I mentioned hereinafter, definitions of substituents from the general definitions mentioned hereinbefoR6may reasonably be used. for example, to replace moR6general definitions with moR6specific definitions or especially with definitions characterized as being preferred. Preference is given to a compound of formual I, wherein n is from 0 to 4, R1is hydrogen, unsubstituted or substituted lower alkyl or halogen, R2 is lower alkyl substituted by hydroxy, unsubstituted, mono- or disubslituted amino or by a heterocyclic radical; a radical R5-(C=Y)-Z-, wherein R5 is unsubstituted or substituted lower alkyl, unsubstituted, mono- or disubslituted amino, a heterocyclic radical, or free or etherified hydroxy. Y is oxygen, sulfur or imino, and Z is either not present, lower alkyl or amino-lower alkyl; or a radical Re-sulfonyiamino-lower alkyl. wherein R6 is unsubstituted or substituted lower alkyl. unsubstituted, mono- or disubslituted amino or phenyl optionally substituted by lower alkyl, lower alkoxy or nitro, with the proviso that R2 is not carboxy, lower alkoxycar-bonyl or lower alkyl substituted by hydroxy if n is 0, R1 is hydrogen. R4 is benzyl and X is -O-, R3 is lower alkyl or lower alkoxy. wherein the R3 substiluents can be selected independently of one another if n>1. R4 is a radical R7-CR8(R9)-. wherein R7 is cyclobutyl. cyclopentyl. cyclohexyl, phenyl, furyl. pyrrolyl, thienyl. pyridyl or phenyl substituted by one or moR6substitutents selected from lower alkyl and halogen, and R3 and Rg areindependently of each other hydrogen, lower alkyl or halogen, and X is selected from -O-. -NH- and -S-. or a salt thereof. Special preference is given to a compound of formula I, wherein n is 0, R1is hydrogen, unsubstituted or substituted lower alkyl or halogen, R2 is lower alkyl substituted by unsubstituted, mono- or disubslituted amino or by a heterocyclic radical; a radical R5-(C=Y)-Z-. wherein R5 is unsubstituted or substituted lower alkyl. unsubstituted. mono- or disubslituted amino, a heterocyclic radical, or if Z is present is also free or etherified hydroxy. Y is oxygen, sulfur or imino. and Z is either not present, lower alkyl or amino-lower alkyl; or a radical R6-sulfonylamino-lower alkyl, wherein R6 is unsubstituted or substituted lower alkyl, unsubstituted. mono- or disubslituted amino or phenyl optionally substituted by lower alkyl, lower alkoxy or nitro. R4 is benzyl, and X is selected from -O-. -NH- and -S-, or a salt thereof. Special preference is further given to a compound of formula I. wherein n is 0, R1is hydrogen, unsubstituted or substituted lower alkyl or halogen, R2 is lower alkyl substituted by a substituted heterocyclic radical; a radical R5-(C=Y)-Z-. wherein R5 is unsubstituted or substituted lower alkyl, unsubstituted, mono- or disubstituted amino, a heterocyclic radical, or if Z is present is also free or etherified hydroxy, Y is oxygen, sulfur or imino. and Z is either not present, lower alkyl or amino-lower alkyl, with the proviso that Z is not present or lower alkyl if R5 is lower alkyl and Z is lower alkyl or amino-lower alkyl if R5 is mono- or disubstituted amino or a heterocyclic radical; or a radical Re-sulfonylamino- lower alkyl. wherein R6 is unsubstituted or substituted lower alkyl, unsubstituted. mono- or disubstituted amino or phenyl optionally substituted by lower alkyl, lower alkoxy or nitro, R4 is benzyl, and X is selected from -O-, -NH- and -S-, or a salt thereof. Preference is especially given to a compound of formula I, wherein n isO. R1is hydrogen, unsubstituted or substituted lower alkyl or halogen, R2 is lower alkyl substituted by amino, N-lower alkylamino, N,N-d!-lower alkylamino or by an unsubstituted heterocyclic radical; or a radical R5-(C=Y)-Z-, wherein R5 is lower alkyl. mono-or disubstituted amino or a heterocyclic radical, Y is oxygen, sulfur or imino, and Z is amino-lower alkyl if R5 is lower alkyl and not present if R5 is a heterocyclic radical or mono- or disubstituted amino, R4 is benzyl, and X is selected from -O-, -NH- and -S-. or a salt thereof. Especially preferred is further a compound of formula I, wherein n is O, R1is hydrogen, unsubstituted or substituted lower alkyl or halogen. R2 is lower alkyl substituted by unsubstituted, mono- or disubstituted amino or by a heterocyclic radical having from 4 to 8 ring members and from 1 to 3 heteroatoms 1hereby at least one heteroatom is nitrogen and the binding of the heterocyclic radical to lower alkyl occurs via a nitrogen ring atom; a radical R5-(C=Y)-Z-, wherein R5 is lower alkyl, unsubstituted, mono- or disubstituted amino, a heterocyclic radical having from 4 to 8 ring members and from 1 to 3 heteroatoms whereby at least one heteroatom is nitrogen and the binding of the heterocyclic radical occurs via a nitrogen ring atom, lower alkyl substituted by said heterocyclic radical or by one or moR6radicals selected independently of one another from the group consisting of amino. N-lower alkylamino, N,N-di-lower alkylamino, N-lower alka-noylamino, N,N-di-lower alkanoylamino, hydroxy, lower alkoxy, lower alkoxy-lower alkoxy, lower alkanoyl, lower alkanoyloxy, cyano, nitro, carboxy, lower alkoxycarbonyl, carbamoyl, amidino. guanidino, ureido, mercapto, lower alkylthio and halogen, or if Z is present is also free or etherified hydroxy, Y is oxygen, sulfur or imino. and Z is either not present, lower alkyl or amino-lower alkyl; or a radical R6-sulfonylamino-lower alkyl, wherein R6 is unsubstituted or substituted lower alkyl, unsubstituted, mono- or disubstituted amino or phenyl optionally substituted by lower alkyl, lower alkoxy or nitro, R4 is benzyl, and X is selected from -O-, -NH- and -S-, or a salt thereof. Very especially preferred is a compound of formula I, wherein n is O, R, is hydrogen, R2 is amino-lower alkyl, N-lower alkylamino-lower alkyl, N,N-di-lower alkylamino-lower alkyl, morpholinyl-lower alkyl, piperidyl-lower alkyl, pyrrolidinyl-lower alkyl, lower alkyl-piperazinyl-lower alkyl, adamantanyl-amino-lower alkyl, hydroxy-piperidyl-lower alkyl, azepanyl-lower alkyl, di-lower alkyl-pyrrolidinyl-lower alkyl, azelidinyl-lower alkyl, aminocarbonyl-piperidyl-lower alkyl, pyridyl-piperazinyl-lower alkyl, thiomorpholinyl-lower alkyl, di-lower alkyl-morpholinyl-lower alkyl, aminocarbonyl-pyrrodinyl-lower alkyl, lower alkoxycarbonyl-piperazinyl-lower alkyl or phenyl-piperazinyl-lower alkyl; a radical R5-{C=Y)-Z-, wherein R5 is lower alkyl, amino, N-lower alkylamino, N.N-di-lower alkylamino, N-(phenyl-lower alkylamino, N-(lower alkyl-phenyl-lower alkyl)-amino, N-(lower alkoxy-phenyl-lower alkyl)-amino, N-(morpholinyl-lower alkyl)-amino, N,N-di-lower alkylamino-lower alkylamino, pyrrolidinyl, piperidyl, morpholinyl, lower alkyl-piperazinyl, piperidyl-lower alkyl, morpholinyl-lower alkyl, lower alkyl-piperazinyl-lower alkyl, lower alkoxy, lower alkoxy-lower alkoxy, lower alkoxy-lower alkyl, lower alkoxy-lower alkoxy-lower alkyl, N,N-di-lower alkylamino-lower alkoxy. mor-pholinyl-lower alkoxy or lower alkyl-piperazinyl-lower alkoxy, Y is oxygen or imino, and Z is either not present or annino-lower alkyl; or a radical Re-sulfonylamino-lower alkyl, wherein R6 is lower alkyl, lower alkyl-phenyl. lower alkoxy-phenyl, nitrophenyl or N,N-di-lower al-kylamino, R4 is benzyl, and X is -O-, or a salt thereof. Especially preferred is further also a compound of formula I. wherein n is 0, R1is hydrogen, lower alkyl or halogen, R2 is a radical selected from the group consisting of hydroxy-lower alkyl, carboxy, lower alkoxycarbonyl. amino-lower alkyl, N-Iower alkylamino-lower alkyl, (tetrahydropyranyl-amino)-lower alkyl, N.N-di-lower alkylamino-lower alkyl, N-lower alkylaminocarbonyl, N.N-di-lower alkylaminocarbonyl. guanidino-lower alkyl. lower alkyl-sulfonylamino-lower alkyl, lower alkoxy-phenyl-sulfonylamino-lower alkyl. lower alkyl-phenyl-sulfonylamino-lower alkyl, nitro-phenyl-sulfonylamino-lower alkyl, N,N-di-lower aikylamino-sulfonylamino-lower alkyl, lower alkoxycarbonylamino-lower alkyl, lower alkoxy-lower alkoxycarbonylamino-lower alkyl, ureido-lower alkyl. N-lower alkylamino-carbonylamino-lower alkyl. N,N-di-lower alkylamino-carbonylamino-lower alkyl, N-(phenyl-lower alkyl)-amino-carbonylamino-lower alkyl, N-(lower alkyl-phenyl-lower alkyl)-amino-carbonylamino-lower alkyl, N-(lower alkoxy-phenyl-lower al-kyl)-amino-carbonylamino-lower alkyl, N-(morpholinyl-lower alkyl)-amino-carbonylamino-lower alkyl. N.N-di-lower alkylamino-lower alkylamino-carbonylamino-lower alkyl, lower alkyl-carbonylamino-lower alkyl, piperidyl-lower alkylcarbonylamino-lower alkyl, morpholinyl-lower alkylcarbonylamino-lower alkyl, lower alkyl-piperazinyl-lower alkylcarbonylamino-lower alkyl, morpholinyl-lower alkyl, piperidyl-lower alkyl. pyrrolidinyl-lower alkyl. [(hydroxy-lower alkyl)-pyrrolidinyl]-lower alkyl. lower alkyl-piperazinyl-lower alkyl, adamantanyl-amino-lower alkyl, hydroxy-piperidyl-lower alkyl. azepanyl-lower alkyl, di-lower alkyl-pyrrolidinyl-lower alkyl, azetidinyl-lower alkyl, aminocarbonyl-piperidyl-lower alkyl, pyridyl-piperazinyl-lower alkyl, thiomorpholinyl-lower alkyl, di-lower alkyl-morpholinyl-lower alkyl. aminocarbonyl-pyrrodinyl-lower alkyl, lower alkoxycarbonyl-piperazinyl-lower alkyl, phenyl-piperazinyl-lower alkyl, lower alkoxy-lower alkylcarbonylamino-lower alkyl, lower alkoxy-lower alkoxy-lower alkylcarbonyl- amino-lower alkyl, pyrrolidinyl-carbonylamino-lower alkyl, piperidyl-carbonylamino-lower alkyl, morpholinyl-carbonylamino-lower alkyl, lower alkyl-piperazinyl-carbonylamino-Iower alkyl, N,N-di-lower alkylamino-lower alkoxycarbonylamino-lower alkyl, mcrpholinyl-lower alkoxy-carbonylamino-lower alkyl and lower alkyl-piperazinyl-lower alkoxycarbonylamino-lower alkyl. with the proviso that R2 is not hydroxy-lower alkyl, carboxy or lower alkoxycarbonyl if R, is hydrogen, R4 is benzyl, and X is -O-. or a salt thereof. Most preferred is a compound of formula I, wherein n is O, R1is hydrogen. R2 is a radical selected from the group consisting of amino-lower alkyl, N-lower alkylamino-lower alkyl, N.N-di-loweralkylamino-lower alkyl, N-lower alkylaminocarbonyl, N,N-di-lower alkylaminocarbonyl, guanidino-lower alkyl. lower alkyl-sulfonylamino-lower alkyl, lower alkoxy-phenyl-sulfonylamino-lower alkyl, lower alkyl-phenyl-sulfonylamino-lower alkyl. nitro-phenyl-sulfonylamino-lower alkyl, N,N-di-lower alkylamino-sulfonylamino-lower alkyl. lower alkoxycarbonylamino-lower alkyl, lower alkoxy-lower alkoxycarbonylamino-lower alkyl. ureido-lower alkyl. N-lower alkylamino-carbonylamino-lower alkyl, N.N-di-lower alkylamino-carbonylamino-lower alkyl. N-(phenyl-lower alkyl)-amino-carbonylamino-lower alkyl. N-(lower alkyl-phenyl-lower alkyl)-amino-carbony!amino-(ower alkyl, N-(lower alkoxy-phenyl-lower al-kyl)-amino-carbonylamino-lower alkyl, N-(morpholinyt-lower alkyl)-amino-carbonylamino-lower alkyl, N,N-di-lower alkylamino-lower alkylamino-carbonylamino-lower alkyl, lower alkyl-carbonylamino-lower alkyl, piperidyl-lower alkylcarbonylamino-lower alkyl, morpholinyl-lower alkylcarbonylamino-lower alkyl, lower alkyl-piperazinyl-lower alkylcarbonylamino-lower alkyl. morpholinyl-lower alkyl. piperidyl-lower alkyl, pyrrolidinyl-lower alkyl, lower alkyl-piperazinyl-lower alkyl, adamantanyl-amino-lower alkyl, hydroxy-piperidyl-lower alkyl, azepanyl-lower alkyl, di-lower alkyl-pyrrolidinyl-lower alkyl, azetidinyl-lower alkyl, aminocarbonyl-piperidyMower alkyl, pyridyl-piperazinyMower alkyl, thiomorpholinyNower alkyf, di-lower alkyl-morpholinyl-lower alkyl, aminocarbonyl-pyrrodinyl-lower alkyl, lower alkoxycarbonyl-piperazinyMower alkyl, phenyl-piperazinyl-lower alkyl, lower alkoxy-lower alkylcarbonylamino-lower alkyl. lower alkoxy-lower alkoxy-lower alkylcarbonylamino-lower alkyl, pyrrolidinyl-carbonylamino-lower alkyl, piperidyl-carbonylamino-lower alkyl. morpholinyl-carbonylamino-lower alkyl. lower alkyl- piperazinyl-carbonylamino-lower alkyl, N,N-di-lower alkylamino-lower alkoxycarbonylamino- lower alkyl, morpholinyl-lower alkoxycarbonylamino-lower alkyl and lower alkyl-piperazinyl- lower alkoxycarbonylamino-lower alkyl, R4 is benzyl, and X is -O-, or a salt thereof. Especially preferred is further a compound of formula I, wherein R2 is in the 3 position of the cyclobutane ring. Very special preference is given to a compound of formula I mentioned in the Examples below, or a salt, especially a pharmaceutically acceptable salt, thereof. Also especially preferred areall compounds of formula I, which in the above-described 'Cap-tuR6ELISA- assay have an IC50 value of less than 300 nM, most preferably those having an IC50 value of less than 100 nM. The compounds of formula I or salts thereof areprepared in accordance with processes known perse (see also WO 97/28161), though not previously described for the manufactuR6of the compounds of the formula I, especially whereby a) in order to preparea compound of formula I, in which R2 is lower alkyl substituted by amino, a compound of formula II wherein n. R1. R3, R4 and X have the meanings as defined for a compound of formula I. is reacted with hydrazine; b) in order to preparea compound of formula I, in which R2 is a radical R5-(C=Y)-Z- wherein R5 is unsubstituted, mono- or disubstituted amino, Y is oxygen and Z is not present or lower alkyl, a compound of formula III in which R10 is a radical HO-(C=0)-Z- wherein Z is not present or lower alkyl, and n. R1, R3. R4 and X have the meanings as defined for a compound of formula I, is reacted with a compound of the formula R5-H wherein R5 is unsubstituted. mono- or disubstituted amino; c) in order to preparea compound of formula I. in which R2 is lower alkyl substituted by mono- or disubstituted amino, a compound of formula l> in which R2 is a radical R5-(C=Y)-Z-wherein R5 is mono- or disubstituted amino, Y is oxygen and Z is not present or lower alkyl, is reacted with lithium aluminium hydride; d) in order to preparea compound of formula I, in which R2 is lower alkyl substituted by mono- or disubstituted amino or by a heterocyclic radical containing at least one nitrogen ring atom whereby the binding of the heterocyclic radical to lower alkyl occurs via a nitrogen ring atom, a compound of formula IV in which R11 is lower alkyl substituted by 4-methylphenylsulfonyloxy and n, R1. R3, R4 and X have the meanings as defined for a compound of formula I. is reacted with a compound of the formula R17-H in which R17 is mono- or disubstituted amino or a heterocyclic radical containing at least one nitrogen ring atom wherein the heterocyclic radical is attached to the hydrogen atom of R17-H via a nitrogen ring atom; e) in order to preparea compound of formula I, in which R2 is a radical Re-sulfonylamino- lower alkyl wherein R6has the meanings as defined above under formula I. a compound of formula I. in which R2 is amino-lower alkyl, is reacted with Re-sulfonyj halide; f) in order to preparea compound of formula I. in which R2 is a radical R5-(C=Y)-Z- wherein R5 is free or etherified hydroxy, Y is oxygen and Z is amino-lower alkyl, a compound of formula I, in which R2 is amino-lower alkyl. is reacted with a compound of the formula R5-(C=0)-Halogen wherein R5 is free or etherified hydroxy; g) in order to preparea compound of formula I, in which R2 is a radical R5-(C=Y)-Z- wherein R5 is unsubstituted or monosubstituted amino. Y is oxygen or sulfur and Z is amino-lower alkyl, a compound of formula I, in which R2 is amino-lower alkyl, is reacted with a compound of the formula Ri2-N=C=Y wherein Y is oxygen or sulfur, the radical R12-NH- corresponding to unsubstituted or monosubstituted amino R5; h) in order to preparea compound of formula I. in which R2 is a radical R5-(C=Y)-Z- wherein R5 is unsubstituted, mono- or disubstituted amino or a heterocyclic radical containing at least one nitrogen ring atom whereby the binding of the heterocyclic radical occurs via a nitrogen ring atom, Y is oxygen and Z is amino-lower alkyl, a compound of formula I, in which R2 is a radical R5-(C=Y)-Z- wherein R5 is imidazol-1-yl. Y is oxygen and Z is amino-lower alkyl. is reacted with a compound of the fomnula R5-H, in which R5 is unsubstituted. mono- or disubsti-tuted amino, or a heterocyclic radical which contains at least one nitrogen ring atom; 1) in order to preparea compound of formula I, in which R2 is a radical R5-(C=Y)-Z- wherein R5 is unsubstituted or substituted lower alkyl, Y is oxygen and Z is amino-lower alkyl. a compound of formula I, in which R2 is amino-lower alkyl, is reacted with a compound of the formula R5-(C=0)-Halogen wherein R5 is unsubstituted or substituted lower alkyl; j) in order to preparea compound of formula I, in which R2 is a radical R5-(C=Y)-Z- wherein R5 is lower alkyl substituted by a heterocyclic radical containing at least one nitrogen ring atom whereby the binding of the heterocyclic radical to lower alkyl occurs via a nitrogen ring atom. Y is oxygen and Z is amino-lower alkyl, a compound of formula V in which n. R1, R3. R4 and X have the meanings as defined for a compound of formula I, is reacted with a compound of the formula R18-H in which R18 is a heterocyclic radical containing at least one nitrogen ring atom wherein the heterocyclic radical is attached to the hydrogen atom of R18-H via a nitrogen ring atom; k) in order to preparea compound of formula I, in which R2 is a radical R5-(C=Y)-Z- wherein R5 is lower alkylamino wherein the lower alkyl moiety is substituted by unsubstituted. mono-or disubstituted amino or by a heterocyclic radical containing at least one nitrogen ring atom whereby the binding of the heterocyclic radical to the lower alkyl moiety occurs via a nitrogen ring atom, Y is oxygen or sulfur and Z is amino-lower alkyl. a compound of formula VI in which Y is oxygen or sulfur and n, R1, R3. R4 and X have the meanings as defined for a compound of formula I. is reacted with a compound of the formula R13-H, in which R13 is un-substituted, mono- or disubstituted amino or a heterocyclic radical containing at least one nitrogen ring atom wherein the heterocyclic radical is attached to the hydrogen atom of R13-H via a nitrogen ring atom; I) in order to preparea compound of formula I, in which R2 is a radical R5-(C=Y)-2- wherein R5 is lower alkoxy substituted by unsubstituted, mono- or disubstituted amino or by a heterocyclic radical containing at least one nitrogen ring atom whereby the binding of the heterocyclic radical to the lower alkyl moiety of lower alkoxy occurs via a nitrogen ring atom, Y is oxygen and Z is amino-lower alkyl, a compound of formula VII in which n. R1, R3, R4 and X have the meanings as defined for a compound of formula I, is reacted with a compound of the formula R14-H, in which R14 is unsubstituted, mono- or disubstituted amino or a heterocyclic radical containing at least one nitrogen ring atom wherein the heterocyclic radical is attached to the hydrogen atom of R14-H via a nitrogen ring atom; m) in order to preparea compound of formula I, in which R1is halogen, a compound of formula I, in which R1is hydrogen, is reacted with N-halosuccinimide; n) in order to preparea compound of formula I, in which R1is lower alkyl, a compound of formula I, in which R1is halogen, is reacted with tetra(lower alkyl) tin; 0) in order to preparea compound of formula I, a compound of formula IX in which n, Ri. R3, R4 and X have the meanings as defined for a compound of formula I. is reacted with a compound of formula X in which R2 has the meanings as defined for a compound of formula I; p) in order to preparea compound of formula I. in which R2 is lower alkyl substituted by hydroxy wherein hydroxy is attached to a primary carbon atom, a compound of formula I, in which R2 is a radical R5-(C=Y)-Z- wherein R5 is etherified hydroxy, Y is oxygen and Z is not present or C1-C6alkyl, is reacted with lithium aluminiumhydride; q) in order to preparea compound of formula I. in which R2 is lower alky! substituted by hydroxy wherein hydroxy is attached to a secondary or tertiary carbon atom, a compound of formula XI in which R15 is a radical R16-(C=O)-Q- wherein R16 is hydrogen or C1-C5alkyI and Q is not present or C1-C5alkyI, is reacted with a Grignard reagent of the formula C1-C6alkyl-Mg-halide; whereby functional groups which arepresent in the starting compounds of processes a) to q) and arenot intended to take part in the reaction, arepresent in protected form if necessary, and protecting groups that arepresent arecleaved, whereby said starting compounds may also exist in the form of salts provided that a salt-forming group is present and a reaction in salt form is possible; and, if so desired, a compound of formula I thus obtained is converted into another compound of formula I, a free compound of formula I is converted into a salt, an obtained salt of a compound of formula I is converted into the free compound or another salt, and/or a mixtuR6of isomeric compounds of formula I is separated into the individual isomers. Description of the process variants: Regarding process a): The reaction between a compound of formula II and hydrazine, in the form of e.g. hydrazine monohydrate, preferably takes place in a suitable inert solvent, especially alcohols, e.g. lower alcohols, such as ethanol and in an inert, for example an argon, atmosphere, prefera- biy at room temperatuR6(RT). Hydrazine is used in excess, preferably about 15 equivalents, compared to the compound of formula II. Regarding process b): The reaction between a compound of formula III and a compound of the formula R5-H, wherein R5 is unsubstituted. mono- or disubstituted amino, preferably takes place in the presence of 0-(1,2-dihydro-2-oxo-1 -pyridyl)-1.1,3,3-tetramethyluronium tetrafluoroborate and diisopropylethylamine. in a suitable inert solvent, such as for example N,N-dimethylformamide, preferably at RT. Regarding process c): The reaction between a compound of formula I, in which R2 is a radical R5-(C=Y)-Z- wherein R5 is mono- or disubstituted amino, Y is oxygen and Z is not present or lower alkyl. and lithium aluminium hydride preferably takes place in a suitable inert solvent, such as for example anhydrous tetrahydrofuran (THF), preferably at temperatures of beween 0 -^C and RT, most preferably by slowly warming the reaction mixtuR6from 0 °C to RT for about 14 hours. Regarding process d): The reaction between a compound of formula IV and a compound of the formula R17-H preferably takes place at RT. If at the reaction temperatuR6the compound of formula R17-H is in the form of a liquid and the compound of formula IV is soluble therein, no additional solvent is needed. Regarding process e): The reaction between a compound of formula I, in which R2 is amino-Iower alkyl, and R6- sulfonyl halide, in which R6 is as defined above under formula I, preferably takes place in the presence of triethylamine, in a suitable inert solvent, such as for example dichloromethane. and in an inert, for example an argon, atmosphere, preferably at about 0 X. In R6-sulfonyl halide, halide is preferably chloride. Regarding process f); The reaction between a compound of formula I, in which R2 is amino-Iower alkyl, and a compound of the formula R5-(C=O)-Halogen, wherein R5 is free or etherified hydroxy and Halo- gen is preferably chlorine, preferably takes place in the presence of triethylamine, in a suitable inert solvent, such as for example dichloromethane, preferably at RT. Regarding process g): The reaction between a compound of formula I, in which R2 is amino-lower alkyl. and a compound of the formula Ri2-N=C=Y preferably takes place in a suitable inert solvent, such as for example acetonitrile, preferably at RT. Regarding process h): The reaction between a compound of formula I, in which R2 is a radical R5-(C=Y)-Z- wherein R5 is imidazoM-yl, Y is oxygen and Z is amino-lower alkyl, and a compound of the formula R5-H, in which R5 is unsubstituted, mono- or disubstituted amino, or a heterocyclic radical which contains at least one nitrogen ring atom, preferably takes place in the presence of triethylamine, in a suitable inert solvent, such as for example acetonitrile. and in an inert, for example an argon, atmosphere, preferably at RT. Regarding process i): The reaction between a compound of formula I. in which R2 is amino-lower alkyl, and a compound of the formula R5-(C=0)-Halogen, wherein R5 is unsubstituted or substituted lower alkyl and Halogen is preferably chlorine, preferably takes place in a suitable inert solvent, such as for example N.N-dimethylformamide. preferably at RT. Regarding process j): The reaction between a compound of formula V and a compound of the formula R18-H preferably takes place in a suitable inert solvent, especially alcohols, e.g. lower alcohols, such as ethanol. preferably at the reflux temperatuR6of the solvent employed. In a compound of formula V, Halogen is preferably chlorine. Regarding process k): The reaction between a compound of formula VI and a compound of the formula R13-H preferably takes place in a suitable inert solvent, especially alcohols, e.g. lower alcohols, such as ethanol, preferably at the reflux temperatuR6of the solvent employed. In a compound of formula VI, Halogen is preferably chlorine or bromine. Regarding process I): The reaction between a compound of formula VII and a compound of the formula R14-H preferably takes place in a suitable inert solvent, such as for example acetonitrile, preferably at the reflux temperatuR6of the solvent employed. In a compound of formula VII, Halogen is preferably bromine. Regarding process m): The reaction between a compound of formula I, in which R1is hydrogen, and N-halosuccinimide, preferably takes place in a suitable inert solvent, such as for example N,N-dimethylfonnamide, and in an inert, for example an argon, atmosphere, preferably at RT in the dark- N-halosuccinimide is preferably N-bromosuccinimide. Regarding process n): The reaction between a compound of formula I. in which R1is halogen, and tetra(lower alkyl) tin. preferably takes place in the presence of tetrakistriphenylphosphin palladium, in a suitable inert solvent, such as for example N,N-dimethylformamide. and in an inert, for example an argon, atmosphere, preferably at elevated temperatuR6such as around 100 °C. Regarding process o): The reaction between a compound of formula IX and a compound of formula X preferably takes place in the presence of a suitable base, such as potassium carbonate, and in the presence of 18-crown-6 ether, in a suitable inert solvent, such as for example N,N-dimethylformamide. preferably at elevated temperatuR6such as around 80oC. Regarding process p): The reaction between a compound of formula I, in which R2 is a radical R5-(C=Y)-Z- wherein R5 is etherified hydroxy. Y is oxygen and Z is not present or C1-C6alkyl, and lithium alumini-umhydride, preferably takes place in a suitable inert solvent, such as for example THF, preferably at around 0 ^'C. Regarding process q): The reaction between a compound of formula XI and a Grignard reagent of the formula C1-C6alkyl-Mg-halide is carried out under conditions known in the art, for example at RT and using diethylether as the solvent. Additional process steps In the additional process steps, carried out as desired, functional groups of the starting compounds which should not take part in the reaction may be present in unprotected form or may be protected for example by one or moR6protecting groups. The protecting groups arethen wholly or partly removed according to one of the known methods. Protecting groups, and the manner in which they areintroduced and removed aredescribed, for example, in -Protective Groups in Organic Chemistry-, Plenum Press, London, New York 1973, and in -Methoden der organischen Chemie-, Houben-Weyl, 4th edition, Vol. 15/1, Georg-Thieme-Verlag, Stuttgart 1974 and in Theodora W. Greene, -Protective Groups in Organic Synthesis-, John Wiley & Sons, New York 1981. A characteristic of protecting groups is that they can be removed readily, i.e. without the occurrence of undesired secondary reactions, for example by solvolysis, reduction, photolysis or alternatively under physiological conditions. The end products of formula I may however also contain substituents that can also be used as protecting groups in starting materials for the preparation of other end products of formula I. Thus, within the scope of this text, only a readily removable group that is not a constituent of the particular desired end product of formula I is designated a -protecting group-, unless the context indicates otherwise. A compound of formula I can be converted to a corresponding N-oxide. The reaction is carried out with a suitable oxidizing agent, preferably a peroxide, for example m-chloroperbenzoic acid, in a suitable solvent, e.g. halogenated hydrocarbon, typically chloroform or dichloromethane. or in a lower alkanecarboxylic acid, typically acetic acid, preferably at a temperatuR6between 0oC and the boiling temperatuR6of the reaction mixture, especially at about RT. General process conditions All process steps described heR6can be carried out under known reaction conditions, preferably under those specifically mentioned, in the absence of or usually in the presence of solvents or diluents, preferably those that areinert to the reagents used and able to dissolve them, in the absence or presence of catalysts, condensing agents or neutralising agents, for example ion exchangers, typically cation exchangers, for example in the H + form, depending on the type of reaction and/or reactants at reduced, normal, or elevated temperature, for example in the range from -100°C to about 190 °C. preferably from about -80 °C to about 150 °C. for example at -80 to -60°C, at RT. at - 20 to 40°C or at the boiling point of the solvent used, under atmospheric pressuR6or in a closed vessel, if need be under pressure, and/or in an inert, for example an argon or nitrogen, atmosphere. The invention relates also to those embodiments of the process in which one starts from a compound obtainable at any stage as an intermediate and carries out the missing steps, or breaks off the process at any stage, or forms a starting material under the reaction conditions, or uses said starting material in the form of a reactive derivative or salt, or produces a compound obtainable by means of the process according to the invention under those process conditions, and further processes the said compound in situ. In the preferred embodiment, one starts from those starting materials which lead to the compounds described hereinabove as preferred. In the preferred embodiment, a compound of formula I (or an N-oxide thereof) is prepared according to the processes and process steps defined in the Examples. The compounds of formula I (or N-oxides thereof), including their salts, arealso obtainable in the form of hydrates, or their crystals can include for example the solvent used for crystallisation (present as solvates). Starting materials New starting materials and/or intermediates, as well as processes for the preparation thereof, arelikewise the subject of this invention. In the preferred embodiment, such starting materials areused and reaction conditions so selected as to enable the preferred compounds to be obtained. The starting materials used in the above described processes a) to q) areknown, capable of being prepared according to known processes (see also WO 97/28161), or commercially obtainable; in particular, they can be prepared using processes as described in the Examples. In the preparation of starting materials, existing functional groups which do not participate in the reaction should, if necessary, be protected. Preferred protecting groups, their introduc- tion and their removal aredescribed above or in the examples. In place of the respective starting materials and transients, salts thereof may also be used for the reaction, provided that salt-forming groups arepresent and the reaction with a salt is also possible. WheR6the term starting materials is used hereinbefoR6and hereinafter, the salts thereof arealways included, insofar as reasonable and possible. A compound of formula II can be prepared for example by reacting a compound of formula VIII wherein n. R1, R3. R4 and X have the meanings as defined for a compound of formula I, with phthalimide, in the presence of triphenylphosphine and diethyl azodicarboxylate, in an inert solvent, for example dry tetrahydrofuran, and in an inert, for example an argon, atmosphere, preferably at RT. A compound of formula VIII can be obtained according to process p) or q). A compound of formula I, in which R2 is a radical R5-(C=Y)-Z- wherein R5 is mono- or disub-stituted amino, Y is oxygen and Z is not present or lower alkyl, can be otained according to process b). A compound of formula IV can be prepared for example by reacting a compound of formula VIII with p-toluenesulfonyl halide, preferably p-toluenesulfonyl chloride, in an inert solvent, for example pyridine, preferably at -20°C. A compound of formula I. in which R2 is amino-lower alkyl, can be obtained according to process a). A compound of formula I, in which R2 is a radical R5-(C=Y)-Z- wherein R5 is imidazol-1-yl, Y is oxygen and Z is amino-lower alkyl, can be obtained for example by reacting a compound of formula I, in which R2 is amino-lower alkyl, with 1,1-carbonyldiimida20le. in the presence of triethylamine. in an inert solvent, for example acetonitrile. and in an inert, for example an argon, atmosphere, preferably at RT. A compound of formula V can be prepared for example by reacting a compound of formula I. in which R2 is amino-lower alkyl. with halogen-lower alkylcarbonyl halide. preferably chloro-lower alkylcarbonyl chloride, in the presence of triethylamine, in an inert solvent, for example acetonitrile. preferably at RT. A compound of formula VI can be obtained for example by reacting a compound of formula I, in which R2 is amino-lower alkyl. with a compound of the formula halogen-lower alkyl-N=C=Y, wherein Y is oxygen or sulfur and halogen is preferably chlorine and bromine, in an inert solvent, for example acetonitrile. preferably at RT. A compound of formula VII can be prepared for example by reacting a compound of formula I. in which R2 is amino-lower alkyl. with halogen-lower alkyl halogen formate, preferably bromo-lower alkyl chloroformate, in the presence of triethylamine, in an inert solvent, for example dichloromethane. preferably at RT. The remaining starting materials areknown, capable of being prepared according to known processes, or commercially available; or in particular, they can be prepared using processes as described in the Examples. Phannaceutical compositions, methods, uses and combinations The present invention relates also to pharmaceutical compositions that comprise a compound of formula I, or a pharmaceutically acceptable salt thereof, as active ingredient and that can be used especially in the treatment of the diseases mentioned at the beginning. The present invention also relates to pro-drugs of a compound of formula I that convert in vivo to the compound of formula I as such. Any reference to a compound of formula I is therefoR6to be understood as referring also to the corresponding pro-drugs of the compound of formula I, as appropriate and expedient. Compositions for enteral administration, such as nasal, buccal, rectal or. especially, oral administration, and for parenteral administration, such as intravenous, intramuscular or subcutaneous administration, to warm-blooded animals, especially humans, areespecially preferred. The compositions contain the active ingredient alone or. preferably, together with a pharmaceutically acceptable carrier. The dosage of the active ingredient depends upon the disease to be treated and upon the species, its age, weight, and individual condition, the individual pharmacokinetic data, and the mode of administration. The invention relates also to compounds of formula I, or a pharmaceutically acceptable salt thereof, as such or in the form of a pharmaceutical composition, for use in a method for the prophylactic or especially therapeutic treatment of the human or animal body, to a process for the preparation thereof (especially in the form of compositions for the treatment of tumours) and to a method of treating the above-mentioned diseases, primarily tumour diseases, especially those mentioned above. The invention relates also to processes and to the use of compounds of formula I, or a pharmaceutically acceptable salt thereof, for the preparation of pharmaceutical compositions which comprise compounds of formula I, or a pharmaceutically acceptable salt thereof, as active component (active ingredient). If desired, the said pharmaceutical compositions may also contain further active components, such as other chemotherapy drugs, and/or may be used in combination with known therapeutic processes, for example the administration of hormonal medicines or radiation. Preference is for a pharmaceutical composition which is suitable for administration to a warm-blooded animal, especially humans or commercially useful mammals suffering from a disease which responds to an inhibition of the IGF-IR tyrosine kinase or of the IGF-IR-dependent cell proliferation, especially a neoplastic disease, comprising an effective quantity of a compound of formula I for the inhibition of the IGF-IR tyrosine kinase or of the IGF-IR- dependent cell proliferation, or a pharmaceutically acceptable salt thereof, together with at least one pharmaceutically acceptable carrier. A pharmaceutical composition for the prophylactic or especially therapeutic management cf neoplastic and other proliferative diseases of a warm-blooded animal, especially a human or a commercially useful mammal requiring such treatment, especially suffering from such a disease, comprising as active ingredient in a quantity that is prophylactically or especially therapeutically active against said diseases a new compound of formula I, or a pharmaceutically acceptable salt thereof, is likewise preferred. The pharmaceutical compositions comprise from approximately 1% to approximately 95% active ingredient, single-dose administration forms comprising in the preferred embodiment from approximately 20% to approximately 90% active ingredient and forms that arenot of single-dose type comprising in the preferred embodiment from approximately 5% to approximately 20% active ingredient. Unit dose forms are. for example, coated and uncoated tablets, ampoules, vials, suppositories or capsules. Examples arecapsules containing from about 0.05 g to about 1.0 g of active substance. The pharmaceutical compositions of the present invention areprepared in a manner known perse, for example by means of conventional mixing, granulating, coating, dissolving or ly-ophilising processes. The invention relates likewise to a process or a method for the treatment of one of the pathological conditions mentioned hereinabove, especially a disease which responds to an inhibition of the IGF-IR tyrosine kinase or of the IGF-IR-dependent cell proliferation, especially a corresponding neoplastic disease. The compounds of formula I. or a pharmaceutically acceptable salt thereof, can be administered as such or in the form of pharmaceutical compositions, prophylactically or therapeutically, preferably in an amount effective against the said diseases, to a warm-blooded animal, for example a human, requiring such treatment, the compounds especially being used in the form of pharmaceutical compositions. In the case of an individual having a bodyweight of about 70 kg the daily dose administered is from approximately 0.1 g to approximately 5 g, preferably from approximately 0.5 g to approximately 2 g. of a compound of the present Invention. The present invention relates especially also to the use of a compound of formula I, or a pharmaceutically acceptable salt thereof, especially a compound of formula I which is said to be preferred, or a pharmaceutically acceptable salt thereof, as such or in the form of a pharmaceutical composition with at least one pharmaceutically acceptable carrier, for the therapeutic and also prophylactic management of one or moR6of the diseases mentioned hereinabove, preferably a disease which responds to an inhibition of the IGF-IR tyrosine kinase or of the IGF-IR-dependent cell proliferation, especially a neoplastic disease, in particular if the said disease responds to an inhibition of the IGF-IR tyrosine kinase or of the IGF-IR-dependent cell proliferation. The present invention relates especially also to the use of a compound of formula I, or a pharmaceutically acceptable salt thereof, especially a compound of formula I which is said to be preferred, or a pharmaceutically acceptable salt thereof, for the preparation of a pharmaceutical composition for the therapeutic and also prophylactic management of one or moR6of the diseases mentioned hereinabove, especially a neoplastic disease, in particular if the disease responds to an inhibition of the IGF-IR tyrosine kinase or of the IGF-IR-dependent cell proliferation. A compound of formula I may also be used to advantage in combination with other antiproliferative agents. Such antiproliferative agents include, but arenot limited to aromatase inhibitors, antiestrogens, topoisomerase I inhibitors, topoisomerase II inhibitors, microtubule active agents, alkylating agents, histone deacetylase inhibitors, farnesyl transferase inhibitors, COX-2 inhibitors, MMP inhibitors, mTOR inhibitors, antineoplastic antimetabolites, platin compounds, compounds decreasing the protein kinase activity and further anti-angiogenic compounds, gonadorelin agonists, anti-androgens. bengamides, bisphosphonates and tras-tuzumab. The term -aromatase inhibitors- as used herein relates to compounds which inhibit the estrogen production, i.e. the conversion of the substrates androstenedione and testosterone to estrone and estradiol, respectively. The term includes, but is not limited to steroids, especially exemestane and formestane and. in particular, non-steroids, especially aminoglu-tethimide, vorozole, fadrozole, anastrozole and, very especially, letrozole. Exemestane can be administered, e.g., in the form as it is marketed, e.g. under the trademark AROMASIN™. Formestane can be administered, e.g., in the form as it is marketed, e.g. under the trade- mark LENTARON'^. Fadrozole can be administered, e.g.. in the form as it is marketed, e.g. under the trademark AFEMA™. Anastrozole can be administered, e.g.. in the form as it is marketed, e.g. under the trademark ARIMIDEX-^. Letrozole can be administered, e.g.. in the form as it is marketed, e.g. under the trademark FEMARA™ or FEMAR™. Aminoglutethim-ide can be administered, e.g., in the form as it is marketed, e.g. under the trademark ORIMETEN™. A combination of the invention comprising an antineoplastic agent which is an aromatase inhibitor is particularly useful for the treatment of hormone receptor positive breast tumors. The term -antiestrogens- as used herein relates to compounds which antagonize the effect of estrogens at the estrogen receptor level. The term includes, but is not limited to tamoxifen, fulvestrant. raloxifene and raloxifene hydrochloride. Tamoxifen can be administered, e.g., in the form as it is marketed, e.g. under the trademark NOLVADEX-^. Raloxifene hydrochloride can be administered, e.g.. in the form as it is marketed, e.g. under the trademark EVISTA™. Fulvestrant can be formulated as disclosed in US 4,659.516 or it can be administered, e.g.. in the form as it is marketed, e.g. under the trademark FASLODEX*^. The term -topoisomerase I inhibitors- as used herein includes, but is not limited to topotecan. irinotecan. 9-nitrocamptothecin and the macromolecular camptothecin conjugate PNU-166148 (compound A1 in WO99/17804). Irinotecan can be administered, e.g.. in the fomR1as it is marketed, e.g. under the trademark CAMPTOSAR™. Topotecan can be administered, e.g.. in the form as it is marketed, e.g. under the trademark HYCAMTIN™. The term -topoisomerase II inhibitors- as used herein includes, but is not limited to the antra-cyclines doxorubicin (including liposomal formulation, e.g. CAELYX™), epirubicin, idarubicin and nemorublcin. the anthraquinones mitoxantrone and losoxantrone. and the podophillotox-ines etoposide and teniposide. Etoposide can be administered, e.g.. in the fomn as it is marketed, e.g. under the trademark ETOPOPHOS™. Teniposide can be administered, e.g., in the form as it is marketed, e.g. under the trademark VM 26-BRISTOL™. Doxorubicin can be administered, e.g., in the form as it is marketed, e.g. under the trademark ADRIBLASTIN™. Epirubicin can be administered, e.g., in the form as it is marketed, e.g. under the trademark FARMORUBICIN^. Idarubicin can be administered, e.g., in the form as it is marketed, e.g. The term -antineoplastic antimetabolites- includes, but is not limited to 5-fluorouracil, 5-fluorouracil, tegafur, capecitabine. cladribine, cytarabine. fludarabine phosphate, fluorouridine, gemcitabine, 6-mercaptopurine, hydroxyurea, methotrexate, edatrexate and salts of such compounds, and furthermoR6ZD 1694 (RALTITREXED™), LY231514 (ALIMTA™), LY264618 (LOMOTREXOL™) and OGT719. The term -platin compounds- as used herein includes, but is not limited to carboplatin, cis-platin and oxaliplatin. Carboplatin can be administered, e.g., in the form as it is marketed, e.g. under the trademark CARBOPLAT™. Oxaliplatin can be administered, e.g., in the form as it is marketed, e.g. under the trademark ELOXATIN™. The term -compounds decreasing the protein kinase activity and further anti-angiogenic compounds- as used herein includes, but is not limited to compounds which decrease the activity of e.g. the Vascular Endothelial Growth Factor (VEGF), the Epidermal Growth Factor (EGF) and c-Src and anti-angiogenic compounds having another mechanism of action than decreasing the protein kinase activity. Compounds which decrease the activity of VEGF areespecially compounds which inhibit the VEGF receptor, especially the tyrosine kinase activity of the VEGF receptor, and compounds binding to VEGF, and arein particular those compounds, proteins and monoclonal antibodies generically and specifically disclosed in WO 98/35958 (describing compounds of formula I), WO 00/09495. WO 00/27820. WO 00/59509. WO 98/11223, WO 00/27819, WO 01/55114. WO 01/58899 and EP 0 769 947; those as described by M. Prewett et al in Cancer Research 59 (1999) 5209-5218. by F. Yuan et al in Proc. Natl. Acad. Sci. USA, vol. 93, pp. 14765-14770. December 1996. by Z. Zhu et al in Cancer Res. 58. 1998, 3209-3214, and by J. Mordenti et al in Toxicologic Pathology, vol. 27, no. 1, pp 14-21,1999; in WO 00/37502 and WO 94/10202; Angiostatin™, described by M. S. O'Reilly et al. Cell 79. 1994, 315-328; and Endostatin™, described by M. S. O'Reilly et al, Cell 88,1997, 277-285; compounds which decrease the activity of EGF areespecially compounds which inhibit the EGF receptor, especially the tyrosine kinase activity of the EGF receptor, and compounds binding to EGF. and arein particular those compounds generically and specifically disclosed in WO 97/02266 (describing compounds of formula IV), EP 0 564 409, WO 99/03854, EP 0520722, EP 0 566 226, EP 0 787 722, EP 0 837 063, WO 98/10767. WO 97/30034. WO 97/49688. WO 97/38983 and. especially. WO 96/33980; compounds which decrease the activity of c-Src include, but arenot limited to. compounds inhibiting the c-Src protein tyrosine kinase activity as defined below and to SH2 interaction inhibitors such as those disclosed in WO97/07131 and WO97/08193; compounds inhibiting the c-Src protein tyrosine kinase activity include, but arenot limited to. compounds belonging to the structuR6classes of pyrrolopyrimidines. especially pyrrolo[2.3-djpyrimidines, purines, pyrazopyrimidines, especially pyrazo[3.4-d]pyrimidines, pyra-zopyrimidines, especially pyrazo[3.4-d]pyrimidines and pyridopyrimidines, especially pyrido[2.3-d]pyrimidines. Preferably, the term relates to those compounds disclosed in WO 96/10028. WO 97/28161. W097/32879 and WO97/49706; anti-angiogenic compounds having another mechanism of action than decreasing the protein kinase activity include, but arenot limited to e.g. thalidomide (THALOMID), SU5416, and celecoxib (Celebrex). The term *'gonadorelin agonist- as used herein includes, but is not limited to abarelix. goserelin and goserelin acetate. Gosereiin is disclosed in US 4,100,274 and can be administered, e.g., in the form as it is marketed, e.g. under the trademark ZOLADEX^^. Abarelix can be formulated, eg. as disclosed in US 5.843,901. The term -anti-androgens- as used herein includes, but is not limited to bicalutamide (CASODEX-^). which can be formulated, e.g. as disclosed in US 4.636,505. The term -bengamides- relates to bengamides and derivatives thereof having aniproliferative properties and includes, but is not limited to the compounds generically and specifically disclosed in WOOO/29382, preferably, to the compound disclosed in Example 1 of WOOO/29382, The term -bisphosphonates- as used herein includes, but is not limited to etridonic acid, clo-dronic acid, tiludronic acid, pamidronic acid, alendronic acid, ibandronic acid, risedronic acid and zoledronic acid. -Etridonic acid- can be administered, e.g., in the form as it is marketed, e.g. under the trademark DIDRONEL™. -Clodronic acid- can be administered, e.g.. in the form as it is marketed, e.g. under the trademark BONEFOS™. -Tiludronic acid- can be administered, e.g., in the form as it is marketed, e.g. under the trademark SKELID™. -Pamidronic acid- can be administered, e.g.. in the form as it is marketed, e.g. under the trademark AREDIA™. -Alendronic acid- can be administered, e.g., in the form as it is marketed, e.g. under the trademark FOSAMAX™. -Ibandronic acid- can be administered, e.g., in the form as it is marketed, e.g. under the trademark BONDRANAT™. -Risedronic acid- can be administered, e.g., in the form as it is marketed, e.g. under the trademark ACTONEL^. -Zoledronic acid- can be administered, e.g., in the form as it is marketed, e.g. under the trademark ZOMETA™. -Trastuzumab- can be administered, e.g., in the form as it is marketed, e.g. under the trademark HERCEPTIN™. For the treatment of AML, compounds of formula I can be used in combination with standard leukemia therapies, especially in combination with therapies used for the treatment of AML. In particular, compounds of formula I can be administered in combination with e.g. farnesyl-transferase inhibitors and/or other drugs used for the treatment of AML, such as Daunorubi-cin, Adriamycin, Ara-C, VP-16, Teniposide, Mitoxantrone, Idarubicin and Carboplatinum. The structuR6of the active agents identified by code nos., generic or trade names may be taken from the actual edition of the standard compendium -The Merck Index- or from databases, e.g. Patents International (e.g. IMS World Publications). The above-mentioned compounds, which can be used in combination with a compound of formula I, can be prepared and administered as described in the art such as in the documents cited above. Examples: The following Examples serve to illustrate the invention without limiting its scope. Temperatures aremeasured in degrees Celsius. Unless otherwise indicated, the reactions take place at RT. Analytical HPLC conditions: Grad 1: Linear gradient over 14 min of MeCN/0.1% TFA and H2O/0.1% TFA from 1:4 to 1:0 and 5 min at 1:0, detection at 215 nm, flow rate 1.0 ml/min. Column: Nucleosil CIS-column (250 X 4.6 mm, 5µm, 100 A). Grad 2: Linear gradient over 7 min of MeCN/0.09% TFA and H2O/0.1% TFA from 1:49 to 1:0 and 3 min at 1:0. detection at 215 nm, flow rate 2.0 ml/min. Column: Nudeosil C18-column (250 X 4.6 mm. 5µm. 100 A). Shorty: Linear gradient over 5 min of MeCN/0.1% TFA and H2O/0.1% TFA from 1:4 to 1:0 and 1 min at 1:0, detection at 215 nm, flow rate 1.0 ml/min. Column: Nudeosil C18-column (70x4 mm, 3 ^m, 100 A). Grad25: isocratic over 25 min of MeCN/0.1 % TFA and H2O/0.1% TFA 1:1. detection at 215 nm. flow rate 1.0 ml/min. Column: Nudeosil C18-column (250x4.6 mm. 5 jim. 100 A). The short forms and abbreviations used have the following definitions: aqu. aqueous ES-MS electron spray-mass spectroscopy h hour(s) Me methyl min minute(s) mp melting point RT room temperature TFA trifluoroacetic acid THF tetrahydrofuran (distilled over Na/benzophenone) tR retention times V volume Example 1: To a solution of 3.84 g (7.25 mmol) of cis-2-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-isoindole-1.3-dione in 100 ml of dry ethanol areadded dropwise at RT and under argon 3.75 g (3.64 ml; 74.96 mmol) of hydrazine monohydrate. After 2 h most of the starting material is not yet dissolved, and additional 1.6 ml of hydrazine monohydrate areadded thereto (total amount: 14.8 equivalents). The reaction is complete after 20 h-. The colorless precipitate is filtered off, and washed with ethanol. The filtrate is evaporated to dryness and the crude compound is purified by chromatography on silicagel (dichloromethane:methanol:aqueous concentrated ammonia = 90:10:1) to pro- vide cis-7-(3-aminomethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2.3-d]pyrim ylamine. Analytical HPLC: tR = 7.47 min (Grad 1); ES-MS: m/eo = 400; 1H-NMR (CDCI3): 8.31/s (1H); 7.3-7.5/m (6H); 7.12/s (1H); 7.05-7.08/2 peaks (2H); 6.99/m (1H); 5.17/m (1H); 5.14/s (2H); 5.04/broad s (2H); 2.87/d (2H); 2.75-2.65/m (2H); 2.2-2.1/ni (2H); 1.55/broad s (2H). Step 1.1: To a solution of 3.5 g (8.74 mmol) of cis-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutyl}-methanol, which is prepared as described in Example 47(b) of WO 97/28161. in 70 mi of dry THF areadded under argon 2.75 g (10.5 mmol) of triphenylphosphine and 1.54 g (10.5 mmol) of phthalimide; 1.9 g (1.71 ml; 10,5 mmol) of diethyl azodicarboxylate (96%) areadded dropwise thereto. After stirring for 16 h at RT, the solution is concentrated to dryness and the crude compound is purified by flash-chromatography (ethylacetate) to provide cis-2-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cydobutylmethyl}-isoindole-1,3-dione. Analytical HPLC: tp = 11.96 min (Grad 1); ES-MS: m/eo = 529.9. Example 2: To a solution of 4.15 g (7.83 mmol) of trans-2-{3-[4-amino-5-(3-ben2yloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-isoindole-1.3-dione in 100 ml of dry ethanol areadded dropwise at RT and under argon 5.87 g (5.7 ml; 117.5 mmol) of hydrazine monohydrate. After 20 min all the starting material is dissolved, and the reaction is complete after 20 h stirring at RT. The colorless precipitate is filtered off, and washed with ethanol. The filtrate is evaporated to dryness and the crude compound is purified by chromatography on silica gel (dichloromethane:methanol:NH40Haqu. = 90:10:1) to provide trans-7-(3-aminomethyl-cyclobutyl)-5-(3-ben2yloxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine. Analytical HPLC: tp = 7.50 min (Grad 1); ES-MS: m/eo = 400; 'H-NMR (CDCI3): 8.30/s (1H); 7.3-7.5/m (6H); 7.20/s (1H); 7.05-7.15/2 peaks (2H); 6.99/m (1H); 5.41/m (1H); 5.14/s (2H); 5.04/broad s (2H); 2.98/d (2H); 2.54-2.69/m (2H); 2.35-2.54/m (3H); 1.73/broad s (2H). Step 2.1: To a solution of 5 g (12.48 mmol) of trans-{3-[4-amino-5-(3-benzytoxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutyl}-methanol, which is prepared as described in Example 47(b) of WO 97/28161, in 100 ml of dry THF areadded under argon 4.91 g (18.72 mmol) of triphenylphosphine and 2.75 g (18.7 mmol) of phthalimide; 3.36 g (3.02 ml; 18.7 mmol) of diethyl azodicarboxylate (96%) areadded dropwise thereto. The reaction mixture is stirred at RT for 27 h. The reaction mixture is concentrated to dryness and the crude compound is pu- rifled by flash-chromatography (ethylacetate) to obtain trans-2-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyr!midin-7-yl]-cyclobutylmethyl}-isoindole-1.3-dione. Analytical HPLC: tp = 12.12 min (Grad 1); ES-MS: m/eo = 529.9. Example 3: To a solution of 45 mg (0.11 mmol) of cis-3-[4-amino-5-(3-ben2yloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutanecarboxylic acid in 2 ml of N,N-dimethylformamide is added 36 mg (0.12 mmol) of 0-(1,2-dihydro-2-oxo-1-pyridyl)-1.1,3,3-tetramethyluronium tetrafluoroborate and 39 nl (0.23 mmol) of diisopropylethylamine. 40 µl of a 5.6 M solution of dimethylamine areadded thereto. After stirring the solution for 15 min at RT, working-up is effected by partitioning between water and ethyl acetate. The organic layer is dried over magnesium sulfate and concentrated in vacuo to provide cis-3-[4-amino-5-(3-ben2yIoxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutanecarboxylic acid dimethylamide. Analytical HPLC: tR= 6.81 min (Grad 2); ES-MS: m/eo = 442.0. Step 3.1: Thecis/trans-3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutanecarboxylic acid methyl ester mixture is prepared as described in Example 47(a) of WO 97/28161. The cis-3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cydobutanecarboxylic acid methyl ester is isolated from the cis/trans mixtureby chromatography on silicagel (t-butyl-methyl-ether:ethylacetate = 1:1). Analytical HPLC: IR = 10.59 min (Grad 1); ES-MS m/eo = 429. Step 3.2: 0.1 g (0.23 mmol) of cis-3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutanecarboxylic acid methyl ester aredissolved in 1.8 ml of THF/1 M LiOH (1:1. v/v). After stirring at RT for 15 min. the pH of the solution is adjusted to pH = 6 with 2N HCI andcis-3-[4-amino-5-(3-benzyloxy-phenyl)-pyrroio[2.3-d]pyrimidin-7-yl]-cyclobutanecarboxylic acid is obtained by filtering the suspension. Anafytical HPLC: tR= 6.61 min (Grad 2); ES-MS: m/eo = 415.0. Example 4: trans-3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutanecarboxylic acid dimethylamide is obtained as described in Example 3 starting with trans-3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutanecarboxylic acid methyl ester [analytical HPLC: XR = 10.71 min (Grad 1); ES-MS m/eo = 429], which is separated from the cis/trans mixture(Example 47(a) of WO 97/28161) by chromatography on silicagel (t-butyl-methyl-ether:ethylacetate =1:1). Analytical HPLC: IR = 6.90 min (Grad 2); ES-MS: m/eo = 442.0. Example 5: cis-3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutanecarboxylic acid methylamide is obtained as described in Example 3 using a 8.03 M solution of methylamine in ethanol. Analytical HPLC: tR= 6.55 min (Grad 2); ES-MS: m/eo = 428.1. Example 6: trans-3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutanecarboxylic acid methylamide is obtained as described in Example 3 starting with trans-3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cydobutanecarboxylic acid and using a 8.03 M solution of methylamine in ethanol. Analytical HPLC: tR= 6.60 min (Grad 2); ES-MS: m/eo = 428.1. Example 7: A solution of 42 mg (0.095 mmol) of cis-3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutanecarboxylic acid dimethylamide in 2 ml of anhydrous THF is added dropwise at 0o C to a 10 mg of lithium aluminium hydride suspended in 2 ml of anhydrous THF. The reaction mixture is slowly warmed to RT overnight. For working-up, the reaction mixture is cooled to 0** C and then water and a 15% NaOH solution areadded in succession thereto. The solution is partitioned between water and ethyl acetate. Drying the organic layer over magnesium sulfate, concentrating in vacuo and purifying by medium-pressuR6liquid chromatography yield cis-5-(3-benzyloxy-phenyl)-7-(3-dimethylaminomethyl-cyclobutyl)-7H-pyrroIo[2.3-d]pyrimidin-4-ylamine. Analytical HPLC: tR= 5.98 min (Grad 2); ES-MS: m/eo = 428.1. Example 8: trans-5-(3-Benzvloxv-phenyl)-7-(3-dimethvlaminomethvl-cvclobutyl)-7H-pyrrolo[2.3-d]pyrimidin-4-ylamine is prepared as described in Example 7 starting with trans-3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutanecarboxylic acid dimethylamide. Analytical HPLC: tR= 6.00 min (Grad 2); ES-MS: m/eo = 428.1. Example 9: cis-5-(3-Ben2yloxy-phenyl)-7-(3-methylaminomethyl-cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine is prepared as described in Example 7 starting with cis-3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutanecarboxylicacid methylamide. Analytical HPLC: tR= 5.96 min (Grad 2); ES-MS: m/eo = 414.1. Example 10: trans-5-(3-Benzyloxy-phenyl)-7-(3-methylaminomethyl-cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine is prepared as described in Example 7 starting with trans- 3'[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutanecarboxylic acid methylamide. Analytical HPLC: tR= 5.95 min (Grad 2); ES-MS: m/eo = 414.1. Example 11: To a solution of 110 mg (0.275 mmol) of trans-7-(3-aminomethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine in 5 ml of acetonitrile is added 72 mg (0.230 mmol) of N,N'-bis-tert-butoxycarbonyl-1-guanylpyrazole (Advanced ChemTech Europe, Machelen, Belgium). After 16 h at RT, the mixture is diluted with 50 ml of ethylace-tate and washed with water. The aqueous phases arediscarded and the organic layer Is dried over magnesium sulfate and evaporated to dryness. The residue is dissolved in 5 ml of formic acid and the solution is stirred for 1 h at RT. The crude mixture is purified by medium-pressuR6liquid chromatography to provide trans-N-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl}-guanidine. Analytical HPLC: tp = 6.12 min (Grad 2); ES-MS: m/eo = 442.0. Example 12: cis-N-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethylj-guanidine is prepared as described in Example 11 using cis-7-(3-aminomethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2.3-d]pyrimidin-4-ylamine. Analytical HPLC: tR = 6.07 min (Grad 2); ES-MS: m/eo = 442.0. Example 13: To a solution of 50 mg (0.125 mmol) of trans-7-(3-aminomethyl-cycIobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2.3-d]pyrimidin-4-ylamine in 2 ml of dry dichloromethane areadded at 0oC and under argon 10 µl (0.131 mmol) of methanesulfochloride and 44 |il (0.313 mmol) of triethylamine. After 20 h, working-up is effected by partitioning between water and dichloromethane. The crude product is purified by chromatography on silicagel (ethyl acetate:methanol = 9:1) to yield trans-N-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyn-olo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-methanesulfonamide. Analytical HPLC: tR = 9.66 min (Grad 1); ES-MS: m/eo = 478.0. Example 14: cis-N-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-methanesulfonamide is prepared as described in Example 13 using cis-7- (3-aminomethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2.3-d]pyrimidin-4-ylamine. Analytical HPLC: IR = 6.84 min (Grad 2); ES-MS: m/eo = 478.0. Example 15: trans-N-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl}-4-methoxy-benzenesulfonamide is prepared as described in Example 13 using p-methoxyphenylsulfochloride. Analytical HPLC: tR = 11.1 min (Grad 1); ES-MS: m/eo = 569.9. Example 16: trans-N-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-4-methyl-benzenesulfonamide is prepared as described in Example 13 using p-toluenesulfochloride. Analytical HPLC: tR= 11.44 min (Grad 1); ES-MS: m/eo = 554. Example 17: trans-N-(3-f4-Amino-5-(3-benzvloxv-phenvl)-pvrrolof2.3-dlpvrimidin-7-vn-cyclobutylmethyl}-4-nitro-benzenesulfonamide is obtained as described in Example 13 using p-nitrophenylsulfochloride. Analytical HPLC: tR= 11.25 min (Grad 1); ES-MS: m/eo = 584.9. Example 18: Propane-2-sulfonic acid trans-(3-[4-amino-5-(3-benzyloxy-ph6nyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl}-amide is obtained as described in Example 13 using 2-propanesulfochloride. Analytical HPLC: IR = 11.14 min (Grad 1); ES-MS: m/eo = 505.9. Example 19: Ethanesulfonic acid trans-(3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-amide is obtained as described in Example 13 using ethanesulfochloride. Analytical HPLC: tR = 10.77 min (Grad 1); ES-MS: m/eo = 492.0. Example 20: N-dimethyl-sulfamide trans-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-amide is prepared as described in Example 13 using di-methylsulfamoyl chloride (Fluka. Buchs. Switzeriand). Analytical HPLC: tR = 7.18 min (Grad 2); ES-MS: m/eo = 506.9. Example 21: N-dimethyl-sulfamidecis-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-amide is prepared as described in Example 13 using cis-7-(3-aminomethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine and dirnethylsulfamoyl chloride (Fluka. Buchs, Switzeriand). Analytical HPLC: tR = 7.15 min (Grad 2); ES-MS: m/eo = 506.9. Example 22: To a solution of 50 mg (0.125 mmol) of trans-7-(3-aminomethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2.3-d]pyrimidin-4-ylamine in 2 ml of dry dichloromethane areadded at RT 12 ^1 (0.150 mmol) of methyl chloroformate (Fluka. Buchs. Switzerland) a.nd 21 |il (0.150 mmol) of triethylamine. After stirring for 2 h at RT. working-up is effected by par titioning between water and ethyl acetate. The organic layer is dried over magnesium sulfate and concentrated in vacuo to provide trans-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3- d]pyrimidin-7-yl]-cyclobutylmethyl}-Carbamic acid methyl ester. Analytical HPLC: tp = 7.08 min (Grad 2); ES-MS: m/eo = 458.0. Example 23: cis-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl}-carbamic acid methyl ester is prepared as described in Example 22 using cis-7-(3-aminomethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2.3-d]pyrimidin-4-ylamine. Analytical HPLC: tp = 7.03 min (Grad 2); ES-MS: m/eo = 458.0. Example 24: trans-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-carbamic acid 2-methoxy-ethyl ester is prepared as described in Example 22 using 2-methoxyethyl chloroformate (TCI America. Portland. OR. U.S.A.). Analytical HPLC: tR= 7.04 min (Grad 2); ES-MS: m/eo = 502.0. Example 25: cis-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl}-carbamic acid 2-methoxy-ethyl ester is prepared as described in Example 22 using cis-7-(3-aminomethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2.3-d]pyrimidin-4-ylamine and 2-methoxyethyl chloroformate (TCI America, Portland. OR, U.S.A.). Analytical HPLC: tR = 7.02 min (Grad 2); ES-MS: m/eo = 502.0. Example 26: To a solution of 50 mg (0.125 mmol) of trans-7-(3-aminomethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrroio[2.3-d]pyrimidin-4-ylamine in 4 ml of dry acetonitrile is added at RT 16 |al (0.2 mmol) of ethyl isocyanate (Fluka. Buchs, Switzerland). After stining for 16 h at RT. working-up is effected by partitioning between water and ethyl acetate. The organic layer is dried over magnesium sulfate and evaporated to dryness to provide trans-1-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-3-ethyl-urea. Analytical HPLC: tp = 6.77 min (Grad 2); ES-MS: m/eo = 471.1. Example 27: cis-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-3-ethyl-urea is prepared as described in Example 26 using cls-7-(3-aminomethyl-cycIobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2,3-d]pyrimldin-4-ylamine. Analytical HPLC: tR = 6.71 min (Grad 2); ES-MS; m/eo = 471.0. Example 28: trans-1-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl}-3-propyl-urea is prepared as described in Example 26 using n-propyl iso-cyanate (Fluka. Buchs, Switzerland). Analytical HPLC: IR = 6. 39 min (Grad 2); ES-MS: m/eo = 485.0. Example 29: cis-1-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-3-propyl-urea is prepared as described in Example 26 using cis-7-(3-aminomethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2.3-d]pyrimidin-4-ylamine and n-propyl isocyanate (Fluka. Buchs. Switzerland). Analytical HPLC: tR = 6.33 min (Grad 2); ES-MS: m/eo = 484.9. Example 30: trans-1-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cycIobutylmethyl}-3-isopropyl-urea is prepared as described in Example 26 using 2-propylisocyanate (Fluka, Buchs, Switzeriand). Analytical HPLC: tR= 6.28 min (Grad 2); ES-MS: m/Bo = 485.0. Example 31: cis-1-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-3-isopropyl-urea is prepared as described in Example 26 using cis-7-(3-aminomethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamineand 2-propylisocyanate (Fluka, Buchs. Switzerland), Analytical HPLC: tR = 6.37 min (Grad 2); ES-MS: m/Bo = 484.9. Example 32: trans-1-{3-[4-Amino-5-(3-benzyloxy-phBnyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmBthyl}-3-butyl-urBa is prepared as described in Example 26 using n-butyl isocyanate (Fluka, Buchs, Switzeriand). Analytical HPLC: tR = 6.53 min (Grad 2); ES-MS: m/Bo = 499.0. Example 33: cis-1 -/3-f4-Amino-5-f3-benzvloxv-phenvl)-pvrrolof2.3-d]pvrimidin'7-yl]-cyclobutylmethyl}-3-butyl-ur6a is prepared as described in Example 26 using cis-7-(3- aminomethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrrolo(2,3-d]pyrinriidin-4-ylamine and n-butyl isocyanate (Fluka, Buchs. Switzerland). Analytical HPLC: IR = 6.54 min (Grad 2); ES-MS: m/eo = 499.0. Example 34: trans-1-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-3-tert-butyl-urea is prepared as described in Example 26 using tert-butyl isocyanate (Fluka. Buchs. Switzerland). Analytical HPLC: tR = 6.60 min (Grad 2); ES-MS: m/eo = 499.0. Example 35: cis-1-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl}-3-tert-butyl-urea is prepared as described in Example 26 using cis-7-(3-aminomethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine and tert-butyl isocyanate (Fluka. Buchs. Switzerland). Analytical HPLC: tp = 6.61 min (Grad 2); ES-MS: m/eo = 499.0. Example 36: trans-1-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl}-3-benzyl-urea is prepared as described in Example 26 using benzyl isocyanate (Fluka, Buchs. Switzerland). Analytical HPLC: tp = 6.88 min (Grad 2); ES-MS: m/eo = 532.9. Example 37: trans-1-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-3-(3-methyl-benzyl)-urea is prepared as described in Example 26 using 3-methylbenzyl isocyanate (Aldrich, Buchs. Switzeriand). Analytical HPLC: tp = 7.50 min (Grad 2); ES-MS: m/eo = 546.9. Example 38: cis-1-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl}-3-(3-methyl-benzyl)-urea is prepared as described in Example 26 using cis-7-(3-aminomethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine and 3'methy I benzyl isocyanate (Aldrich, Buchs, Switzeriand). Analytical HPLC: tR = 7.45 min (Grad 2); ES-MS: m/eo = 546.9. Example 39: cis-1-{3-[4-Amino-5-(3-benzyloxy-phenyl)'Pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-3-(4-methoxy-benzyl)-urea is prepared as described in Example 26 using cis-7-(3-aminomethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-7H-pyn'olo[2,3-d]pyrimidin-4- ylamine and 4-methoxybenzyl isocyanate (Aldrich, Buchs, Switzerland). Analytical HPLC: IR = 7.21 min (Grad 2); ES-MS: m/eo = 562.9. Example 40: To a solution of 41 mg (0.075 mmol) of trans-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-3-(2-bromo*ethyl)-urea. which is prepared as described in Example 26 using 2-bromoethyl isocyanate (Aldrich, Buchs, Switzerland), in 5 ml of ethanol is added 33µl (0.375 mmol) of morpholine. The mixture is refluxed for 3 h and the crude mixture is purified by medium-pressuR6liquid chromatography to provide trans-1-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-3-(2-morpholin-4-yl-ethyl)-urea. Analytical HPLC: IR = 6.12 min (Grad 2); ES-MS: m/eo = 555.9. Example 41: cis-1-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-3-(2-morphorin-4-yl-ethyl)-urea is prepared as described in Example 40 using cis-7-(3-aminomethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine as starting material. Analytical HPLC: tp = 6.04 min (Grad 2); ES-MS: m/eo = 555.9. Example 42: trans-1-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d3pyrimidin-7-yl]-cyclobutylmethyl}-3-(2*dimethylamino-ethyl)-urea is prepared as described in Example 40 using dimethylamine (5.6 M solution in ethanol; Fluka, Buchs, Switzerland). Analytical HPLC: tR = 6.08 min (Grad 2); ES-MS: m/eo = 514.0. Example 43: cis-1-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-3-(2-dimethylamino-ethyl)>urea is prepared as described in Example 40 using cis-7-(3-aminomethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine as starting material and dimethylamine (5.6 M solution in ethanol; Fluka. Buchs. Switzerland). Analytical HPLC: IR = 5.98 min (Grad 2); ES-MS: m/eo = 514.0. Example 44: trans-1 -{3-[4-Amino-5-(3-benzvloxv-phenvl)-pvrrolof2.3-d]pyrimidin-7-vl'|-cyclobutylmethyl}-3-(3-morpholin-4-yl-propyl)-urea is prepared as described in Example 40 using 3-chlQropropyl isocyanate (Aldrich, Buchs, Switzeriand). Analytical HPLC: tR = 6.12 min (Grad 2); ES-MS: m/eo = 569.9. Example 45: cis-1-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-3-(3-morpholin-4-yl-propyl)-urea is prepared as described In Example 40 using cis-7-(3-aminomethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrro!o[2.3-d]pyrimidin-4-ylamine and 3-chloropropyl isocyanate. Analytical HPLC: \R = 5.93 min (Grad 2); ES-MS: m/eo = 570.0. Example 46: trans-1-{3-[4-Amino-5-(3-ben2yloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-3-(3-dimethylamino-propyl)-urea is prepared as described in Example 40 using 3-chloropropyl isocyanate and dimethylamine. Analytical HPLC: IR = 6.09 min (Grad 2); ES-MS: m/eo = 528.0. Example 47: cis-1-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl}-3-(3-dimethylamino-propyl)-urea is prepared as described in Example 40 using cis-7-(3-aminomethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine, 3-chloropropyl isocyanate and dimethylamine. Analytical HPLC: tp = 5.95 min (Grad 2); ES-MS: m/eo = 528.0. Example 48: To a solution of 50 mg (0.125 mmol) of trans-7-(3-aminomethyl-cyclobutyl)-5-(3-benzyioxy-phenyl)-7H-pyrroio[2.3-d]pyrimidin-4-ylamine in 5 ml of methanol is added 45 mg (0.561 mmol) of potassium cyanate (Aldrich, Buchs, Switzerland). The mixture is refluxed for one week. After concentration to dryness, the residue is purified by flash-chromatography (dichloromethane:methanol = 9:1) to provide trans-{3-[4-amino-5-(3-ben2yloxy-phenyl)-pyrrolo(2,3-d]pyrimidin-7-yl]-cydobutylmethyl}-urea. Analytical HPLC: t^ = 6.43 min (Grad 2); ES-MS: m/eo = 443.0. Example 49: cis-{3-[4-Amino-5-(3'benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yi]-cyclobutylmethyl}-urea is prepared as described in Example 48 using cis-7-(3-aminomethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2.3-d]pyrimidin-4-ylamine. Analytical HPLC: tp = 6.37 min (Grad 2); ES-MS: m/eo = 442.9. Example 50: To a solution of 50 mg (0.125 mmol) of trans-7-(3-aminomethyl-cydobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine in 2 ml of anhydrous N,N-dimethylformamide is added 13\x\ (0.138 mmol) of acetic anhydride (Fluka, Buchs. Switzerland). After stirring 1 h at RT, working-up is effected by partitioning between water and ethyl acetate. The organic layer is dried over magnesium sulfate and evaporated to dryness to provide trans-N-{3-[4-amino-5-(3-ben2yloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl}-acetamide. Analytical HPLC: tR = 6.65 min (Grad 2); ES-MS: m/eo = 442.0. Example 51: cis-N-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl}-acetamide is prepared as described in Example 50 using cis-7-(3-aminomethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine. Analytical HPLC: IR = 6.59 min (Grad 2); ES-MS: m/eo = 442.0. Example 52: trans-N-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl}-isobutyramide is prepared as described in Example 50 using isobutyril chloride (Fluka. Buchs, Switzerland). Analytical HPLC: IR = 7.00 min (Grad 2); ES-MS: m/eo = 470.0. Example 53: cis-N-{3-[4-Amino-5-(3-benzyIoxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutyImethyl}-isobutyramide is prepared as described in Example 50 using cis-7-(3-aminomethyl-cyclobutyl)-5-(3-ben2yloxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine and isobutyril chloride (Fluka. Buchs. Switzerland). Analytical HPLC: \R = 6.95 min (Grad 2); ES-MS: m/eo = 470.0. Example 54: trans-N-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-2.2-dimethyl-propionamide is prepared as described in Example 50 using pivaloyi chloride (Fluka, Buchs. Switzerland). Analytical HPLC: tR = 7.30 min (Grad 2); ES-MS: m/eo = 484.0. Example 55: cis-N-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyn'olo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-2,2-dimethyl-propionamide is prepared as described in Example 50 using cis-7-(3-aminomethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2.3-d]pyrimidin-4-ylamine and pivaloyi chloride (Fluka, Buchs, Switzeriand). Analytical HPLC: tR = 7.25 min (Grad 2); ES-MS: m/eo = 484.0. Example 56: 48 mg (0.1 mmol) of trans-N-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-2-chloro-acetamide and 25 jxl (0.3 mmol) of piperidine in 5 ml of ethanol arerefluxed for 2 h. trans-N-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrroIo[2,3- d]pyrimidin-7-yl]-cyclobutylmethyl}-2-piperidin-1-yl-acetamide is obtained after purification of the crude mixtureby medium-pressuR6liquid chromatography. Analytical HPLC: tR = 6.17 min (Grad 2); ES-MS: m/eo = 525.0. Step 56.1: To a suspension of 210 mg (0.53 mmoi) of trans-7-(3-aminomethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine in 10 ml of acetonitrile is added 49 |al (0.61 mmol) of chloro-acetyl chloride (Fluka, Buchs. Switzerland) and 85 |il (0.61 mmol) of triethylamine. The solution is stirred for 5 h at RT. trans-N-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-2-chlorO-acetamide is obtained after purification of the crude mixtureby medium-pressuR6liquid chromatography. Analytical HPLC: tp = 6.94 min (Grad 2); ES-MS: m/eo = 476.0. Example 57: cis-N-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-2-piperidin-1-yl-acetamide is obtained as described in Example 56 starting with cis-7-(3-aminomethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine. Analytical HPLC: tp = 6.14 min (Grad 2); ES-MS: m/eo = 525.0. Example 58: trans-N-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl}-2-morpholin-4-yl-acetamide is obtained as described in Example 56 using morpholine. Analytical HPLC: tR = 6.03 min (Grad 2); ES-MS: m/eo = 526.9. Example 59: cis-N-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl}-2-morpholin-4-yl-acetamide is obtained as described in Example 56 starting with cis-7-(3-aminomethyl-cyclobutyl)-5'(3-benzyloxy-phenyl)-7H-pyrrolo[2.3-d]pyrimidin-4-ylamine and using morpholine. Analytical HPLC: tp = 5.98 min (Grad 2); ES-MS: m/eo = 527.0. Example 60: trans-N-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl}-2-(4-methyl-piperazin-1-yl)-acetamide Is obtained as described in Example 56 using 1-methyl-piperazine. Analytical HPLC: tp = 5.87 min (Grad 2); ES-MS: m/eo = 539.9. Example 61: cis-N-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-2-(4-methyl-piperazin-1-yl)-acetamide is obtained as described in Example 56 starting with cis-7-(3-aminomethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine and using 1-methyl-piperazine. Analytical HPLC: tR = 5.83 min (Grad 2); ES-MS: m/eo = 539.9. Example 62: A solution of 50 mg (0.09 mmol) of trans-toluene-4-sulfonic acid 3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl ester in 1 ml of mor-pholine (Fluka. Buchs, Switzerland) is stirred at RT for 72 h. The solvent is evaporated to dryness and the residue is purified by flash-chromatography (ethylace- tate:methanol:NH40Haqu. = 95:5:1) to provide trans-5-(3-benzyloxy-phenyl)-7-(3-morpholln-4-ylmethyl-cyclobutyl)-7H-pyrrolo[2.3-d]pyrimidin-4-ylamine. Analytical HPLC: tR = 9.29 min (Grad 1); ES-MS: m/eo = 470.0. Step 62.1: 200 mg (0.49 mmol) of trans-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutyl}-methanol, which is prepared as described in Example 47(b) of WO 97/28161. aredissolved in 2 ml of pyridine and the solution is cooled to -20 -C. 153 mg (0.8 mmol) of p-toluenesulfonyl chloride areadded to this solution and the reaction mixture is left overnight in the freezer at -20oC. Then, 10 ml of ice-cold water areadded and the mixture is extracted with cold dichloromethane. The aqueous phase is discarded and the organic phase is washed with cold water/2N H2SO4 and water. The organic layer is dried over magnesium sulfate and evaporated to dryness to provide trans-toluene-4-sulfonic acid 3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl ester, which was used in the next step without further purification. Analytical HPLC: tp = 13.09 min (Grad 1); ES-MS: m/eo = 554.9. Example 63: trans-5-(3-Benzyloxy-phenyl)-7-(3-piperidin-1-ylmethyl-cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine is prepared as described in Example 62 using piperidine (Fluka. Buchs. Switzerland). Analytical HPLC: IR = 9.93 min (Grad 1); ES-MS: m/eo = 468.0. Example 64: trans-5-(3-Benzyloxy-phenyl)-7-(3-pyrrolidin-1-ylmethyl-cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine is prepared as described in Example 62 using pyrrolidine (Fluka, Buchs. Switzerland). Analytical HPLC: tR = 9.59 min (Grad 1); ES-MS: m/eo = 454.0. Example 65: trans-5-(3-Benzyloxy-phenyl)-7-[3-(4-methyl-piperazin-1-ylmethyl)-cyclobutyl]-7H-pyrrolo[2,3-d]pyrimldin-4-ylamine is prepared as described in Example 62 using 1-methyl- piperazine (Fluka. Buchs, Switzerland). Analytical HPLC: IR = 5.68 min (Grad 2); ES-MS: m/eo = 483.3. Example 66: 50 mg (0.09 mmol) of trans-toluene-4-sulfonic acid 3-[4-amino-5-(3-benzyloxi'-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl ester and 34 mg (0.225 mmol) of ada-mantan-1-ylamine (Fluka. Buchs. Switzerland) in 1 ml N,N-dimethylformamide arestirred for 18 h at RT and for 24 h at 60'oC. Additional adamantan-1-ylamine is added (34 mg) and stirring is continued for 24 h at 120oC. The solvent is evaporated to dryness and the residue is purified by flash-chromatography (ethylacetate:methanol:NH40Haqu. = 95:5:1) to provide trans-7-[3-(adamantan-1-ylaminomethyl)-cyclobutyl]-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2.3-d]pyrimidin-4-ylamine. Analytical HPLC: tR =11.14 min (Grad 1); ES-MS: m/eo = 533.9. Example 67: trans-1-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo{2.3-d]pyrimidin-7-yl]-cyclobutylmethyl}-piperidin-4-ol is prepared as described in Example 62 using 4-hydroxypiperidine (Fluka, Buchs. Switzerland). Analytical HPLC: tp = 8.52 min (Grad 1); ES-MS: m/eo = 484.2. Example 68: trans-7-(3-/\zepan-1-ylmethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine is prepared as described in Example 62 using hexamethyl-eneimine (Fluka, Buchs, Switzerland). Analytical HPLC: IR = 9.49 min (Grad 1); ES-MS: m/eo = 482.3. Example 69: trans-5-(3-Benzyloxy-phenyl)-7-[3-(2.5-dimethyl-pyrrolidin-1-ylmethyl)-cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine is prepared as described in Example 62 using 2,5-dimethylpyrrolidine (cis/trans) (Brunswig Chemie, Basel. Switzerland). Analytical HPLC: tR = 9.38 min (Grad 1); ES-MS: m/eo = 482.2. Example 70: trans-7-(3-Azetidin-1-ylmethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2.3-d]pyrimidin-4-ylamine is prepared as described in Example 62 using trimethyle-neimine (Fluka. Buchs. Switzerland). Analytical HPLC: tR = 8.89 min (Grad 1); ES-MS: m/eo = 440.2. Example 71: trans-1-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl}-piperidine-3-carboxylic acid amide is prepared as described in Example 62 using R,S-nipecotamide (Aldrich, Buchs, Switzerland). Analytical HPLC: IR = 8.52 min (Grad 1);ES-MS:m/eo = 511.0. Example 72: trans-5-(3-Benzyloxy-phenyl)-7-[3-(4-pyridin-2-yl-piperazin-1-ylmethyl)-cyciobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine is prepared as described in Example 62 using 1-(2-pyridyl)-piperazine (Aldrich, Buchs. Switzerland). Analytical HPLC: tp = 8.15 min (Grad 1); ES-MS: m/eo = 546.2. Example 73: trans-5-(3-Benzyloxy-phenyl)-7-(3-thiomorpholin-4-ylmethyl-cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine is prepared as described in Example 62 using thiomor-pholine (Fluka. Buchs, Switzerland). Analytical HPLC: IR = 9.26 min (Grad 1); ES-MS: m/eo = 486.2. Example 74: trans-5-(3-Benzyloxy-phenyl)-7-[3-(2.6-dimethyl-morpholin-4-ylmethyl)-cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine is prepared as described in Example 62 using cis/trans-2.6-dimethylmorpholine (Fluka. Buchs. Switzerland). Analytical HPLC: IR = 9.39 min (Grad 1); ES-MS: m/eo = 498.2. Example 75: trans-(S)-1-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl}-pyrrolidine-2-carboxylic acid amide is prepared as described in Example 62 using L-prolinamide (Aldrich. Buchs, Switzerland). Analytical HPLC: tp = 8.56 min (Grad 1); ES-MS: m/eo = 497.2. Example 76: cis-7-(3-Azepan-1-ylmethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2.3-d]pyrimidin-4-ylamine is prepared as described in Example 62 using cis-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutyl}-methanol, which is prepared as described in Example 47(b) of WO 97/28161, as starting material and hexamethyleneimine (Fluka. Buchs. Switzerland). Analytical HPLC: tR = 9.51 min (Grad 1); ES-MS: m/eo = 482.2. Example 77: cis-1-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cydobutylmethyl}-piperidin-4-ol is prepared as described in Example 76 using 4-hydroxypiperidine (Fluka. Buchs, Switzerland). Analytical HPLC: IR = 8.36 min (Grad 1); ES-MS: m/Bo = 484.2. Example 78: cis-4-{3-[4-Amino-5-(3-ben2yloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-piperazine-1-carboxylic acid ethyl ester is prepared as described in Example 76 using 1-ethoxycarbonylpiperazine (Fluka, Buchs. Switzerland). Analytical HPLC: tR = 9.23 min (Grad 1); ES-MS: m/eo = 541.2. Example 79: cis-5-(3-Benzyloxy-phenyl)-7-[3-(4-phenyl-piperazin-1-ylmethyl)-cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine is prepared as described in Example 76 using 1-phenylpiperazine (Fluka, Buchs. Switzerland). Analytical HPLC: tR = 10.24 min (Grad 1); ES-MS: m/eo = 545.1. Example 80: cis-5-(3-Benzyloxy-phenyl)-7-[3-(4-methyl-piperazin-1-ylmethyl)-cyclobutyl]-7H-pyrrolo[2.3-d]pyrimidin-4-ylamine is prepared as described in Example 76 using 1-methylpiperazine (Fluka. Buchs, Switzerland). Analytical HPLC: tR = 7.87 min (Grad 1); ES-MS: m/eo = 483.2. Example 81: cis-5-(3-Benzyloxy-phenyl)-7-(3-thiomorpholin-4-ylmethyl-cyclobutyl)-7H-pyrrolo[2.3-d]pyrimidin-4-ylamine is prepared as described in Example 76 using thiomor-pholine (Fluka. Buchs. Switzerland). Analytical HPLC: IR = 9.08 min (Grad 1); ES-MS: m/eo = 486.1. Example 82: cis-5-(3-Ben2vloxv-phenyl)-7-f3-(2.6'dimethvl-morpholin-4-vlmethvl)-cyclobutvl]-7H-pyrrolo[2.3-d]pyrimidin-4-ylamine is prepared as described in Example 76 using cis/trans-2.6-dimethylmorpholine (Fluka, Buchs. Switzeriand). Analytical HPLC: IR = 9.27 min (Grad 1); ES-MS: m/eo = 498.2. Example 83: cis-(R)-1-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-pyrrolidine-2-carboxylic acid amide is prepared as described in Example 76 using L-prolinamide (Aldrich, Buchs. Switzerland). Analytical HPLC: IR = 8.53 min (Grad 1); ES-MS: m/eo = 497.1. Example 84: cis-1-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-ylJ-cyclobutylmethyl}-piperidine-3-carboxylic acid amide is prepared as described in Example 76 using L,D-nipecotamide (Aldrich, Buchs, Switzeriand). Analytical HPLC: tp = 8.46 min (Grad 1); ES-MS: m/eo = 511.2. Example 85: trans-N-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-2-ethoxy-acetamide is prepared starting from trans-7-(3-aminomethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine and ethoxy-acetic acid (Fluka. Buchs, Switzerland) according to a proceduR6known in the art (M. Bodanszky in Principles of Peptide Synthesis, Akad.-Verlag, 1984). Analytical HPLC: tp = 7.07 min (Grad 2); ES-MS: m/eo = 486.2. Example 86: trans-N-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl}-2-(2-methoxy-ethoxy)-acetamide is prepared starting from trans-7-(3-aminomethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamineand 2-(2-methoxyethoxy)-acetic acid (Fluka, Buchs, Switzerland) according to a proceduR6known in the art (M. Bodanszky in Principles of Peptide Synthesis, Akad.-Verlag, 1984). Analytical HPLC: tR = 6.91 min (Grad 2); ES-MS: m/eo = 516.2. Example 87: trans-1-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-3-methyl-urea is prepared as described in Example 26 starting with methyl isocyanate (ChemService Inc., West Chester, PA. U.S.A.). Analytical HPLC: tR = 6.55 min (Grad 2); ES-MS: m/eo = 457.0. Example 88: cis-1-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-3-methyl-urea is prepared as described in Example 26 starting with cis-7-(3-aminomethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamineand methyl isocyanate (ChemService Inc., West Chester, PA, U.S.A.). Analytical HPLC: tR = 6.49 min (Grad 2); ES-MS: m/eo = 456.9. Example 89: To a suspension of 0.2 g (0.5 mmol) of trans-7-(3-aminomethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine in 5 ml of acelonitrile areadded under argon 108 mg (0.65 mmol) of 1,1-carbonyldiimidazole (Fluka, Buchs. Switzerland) and 628 µll (4.5 mmol) of triethylamine. The reaction mixture is stirred for 15 min at RT and 414 ^il (5.0 mmol) of pyrrolidine (Fluka, Buchs, Switzeriand) areadded thereto. After stining for 2.5 h at RT, the reaction mixture is concentrated and the crude compound is purified by re-versed-phase medium pressuR6chromatography to provide trans-pyrrolidine-1-carboxylic acid {3-[4-aminO-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-amide. Analytical HPLC: IR = 7.02 min (Grad 2); ES-MS: m/eo = 497.2. Example 90: trans-Pip6ridine-1-carboxylic acid {3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-amide is prepared as described in Example 89 using piperidine (Fluka. Buchs. Switzerland). Analytical HPLC: IR = 7.30 min (Grad 2); ES-MS: m/eo = 511.2. Example 91: trans-Morpholine-4-carboxylic acid {3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl}-amide is prepared as described in Example 89 using morpholine (Fluka, Buchs, Switzerland). Analytical HPLC: tp = 6.72 min (Grad 2); ES-MS: m/eo = 513.2. Example 92: trans-3-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-1.1-dimethyl-urea is prepared as described in Example 89 using dimethyl-amine (Fluka, Buchs, Switzerland). Analytical HPLC: IR = 6.82 min (Grad 2); ES-MS: m/e© = 471.3. Example 93: trans-4-Methyl-piperazine-1-carboxylic acid {3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-amide is prepared as described in Example 89 using 1-methylpiperazine (Fluka. Buchs, Switzerland). Analytical HPLC: IR = 6.01 min (Grad 2); ES-MS: m/eo = 526.2. Example 94: trans-3-/3-f4-Amino-5-(3-ben2vloxv-phenvl)-pyrrolof2,3-d1pyrimidin-7-vn-cyclobutylmethyl}-1,1-diethyl-urea is prepared as described in Example 89 using diethyl-amine (Fluka. Buchs, Switzerland). Analytical HPLC: tp = 7.22 min (Grad 2); ES-MS: m/eo = 499.2. Example 95: To a solution of 0.2 g (0.5 mmol) of trans-7-(3-aminomethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2.3-d]pyrimidin-4-ylamine in 5 ml of dichloromethane areadded 55.4 jil (0.5 mmol) of 2-bromoethyl chloroformate (Fluka. Buchs, Switzerland) and 70 |il (0.5 mmol) of triethylamine. After stirring for 2 h at RT, the solution is concentrated to dryness. The crude compound is dissolved in 5 ml of acetonitrile and 260µl (2.5 mmol) of di-ethylamine (Fluka, Buchs, Switzerland) areadded thereto. The reaction mixture is refluxed for 16 h and. after concentration, the crude compound is purified by medium-pressuR6liquid chromatography to provide trans-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-carbamic acid 2-diethylamino-ethyl ester. Analytical HPLC: tR = 6.27 min (Grad 2); ES-MS: m/eo = 543.3. Example 96: trans-{3-[4-Amino-5-{3-ben2yloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cydobutylmethyl}-carbamic acid 2-morpholin-4-yl-ethyl ester is prepared as described in Example 95 using morpholine (Fluka, Buchs. Switzerland). Analytical HPLC: tR = 6.18 min (Grad 2); ES-MS: m/eo = 557.2. Example 97: trans-{3-[4-Amino-5-(3-ben2yloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl}-carbamic acid 2-(4-methyl-piperazin-1-yl)-ethyl ester is prepared as described in Example 95 using 1-methylpiperazine (Fluka, Buchs. Switzerland). Analytical HPLC: IR = 5.88 min (Grad 2); ES-MS: m/eo = 570.2. Example 98: trans-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl}-carbamic acid 2-dimethylamino-ethyl ester is prepared as described in Example 95 using dimethylamine (Fluka, Buchs, Switzerland). Analytical HPLC: tp = 6.14 min (Grad 2); ES-MS: m/eo = 515.2. Example 99: trans-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl}-carbamic acid ethyl ester is prepared as described in Example 22 using ethyl chloroformate (Fluka. Buchs. Switzerland). Analytical HPLC: tR = 7.32 min (Grad 2); ES-MS: m/eo = 472.2. Example 100: trans-4-{3-[4-Amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl}-piperazine-1-carboxylic acid ethyl ester is prepared as described in Example 62 using 1-ethoxycarbonylpiperazine (Fluka, Buchs. Switzerland). Analytical HPLC: tp = 9.25 min (Grad 1); ES-MS: m/eo = 541.2. Example 101: cis-5-(3-Benzyloxy-phenyl)-7-(3-pyrrolidin-1-ylmethyl-cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine is prepared as described in Example 76 using pyrrolidine (Fluka, Buchs. Switzerland). Analytical HPLC: tp = 9.01 min (Grad 1); ES-MS: m/eo = 454.2. Example 102: cis-7-(3-Azetidin-1-ylmethyl-cyclobutyl)-5-(3-benzy!oxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine is prepared as described in Example 76 using trimethyleneimine (Fluka, Buchs, Switzerland). Analytical HPLC: tR = 8.80 min (Grad 1); ES-MS: m/eo = 440.2. Example 103: trans-3-[4-Amino-5-(3-benzyloxy-phenyl)-6-bromo-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutanecarboxylic acid methylester To 11g (25.67 mmol) trans-3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutanecarboxylic acid methyl ester (see Example 4) in 275 ml dry N.N-dimethylformamide. 5.18 g (28.24 mmol) N-bromosuccinimide areadded in small portions. The solution is stirred at RT in the dark and under Argon for 17 h. Thereafter the solvent is evaporated, and the residue purified by chromatography on silicagel (solvent: hexane-ethyl acetate 3:1). Further purification is done by crystallization from acetonitrile. Analytical HPLC: tp = 3.61 min (shorty); ES-MS: m/eo = 506.9 and 508.9; mp: 124-125X; NMR (DMSO-d6): 8.18/s(1H), 7.25-7.5/several m's(6H), 7.09rd-(1H); 7.04/s(1H); 6.98/-d-(1H); 5.38/m (1H); 5.13/s (2H); 3.69/s (3H); 3.50/m (2H); 3.29/m (1H); 2.62/m (2H). Example 104: trans-3-[4-Amino-5-(3-benzyloxy-phenyl)-6-methyl-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutanecarboxylic acid methyl ester In a sealed tube, 4.68 g (9.02 mmol) trans-3-[4'amino-5-(3-ben2yloxy-phenyl)-6-bromo-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutanecarboxylic acid methylester of Example 103. 2.08 g (1.8 mmol) tetrakistriphenylphosphin palladium and 5.3 ml (38.05 mmol) tin tetramethyl (Fluka. Buchs. Switzerland) areheated under Argon in 20 ml dry N,N-dimelhylformamide for 30 h at 100-105°C bath temperature. The reaction mixture is filtered on hyflo (Hyflo Super Cel®; Fluka. Buchs. Switzerland), and the residue washed thouroughly with N.N-dimethylformamide. The dark filtrate is evaporated at 60oC to dryness, the residual mass dissolved in hot ethyl acetate and chromatographed on silicagel (hexane-ethyl acetate 25:75). The title compound is obtained as yellow crystals. Analytical HPLC: IR = 3.54 min (shorty); ES-MS: m/eo = 443; NMR (DMS0-d6): 8.08/s(1H). 7.25-7.5/several m's(6H), 6.99rd-(1H); 6.90/s(1H); 6.85/-d-(1H); 5.09/s (2H); 5.06/m (1H); 3.64/s (3H); 3.2-3.5/2xm (3H); 2.59/m (2H); 2.18/s (3H). Example 105: trans-{3-[4-Amino-5-(3-benzyloxy-phenyl)-6-methyl-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutyl}-methanol 2.94 g (6.64 mmol) trans-3-[4-amino-5-(3-benzyloxy-phenyl)-6-methyl-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutanecarboxylic acid methyl ester of Example 104 in 35 ml dry THF areadded during 45 min to an ice-cold solution of 0.281 g (7.17 mmol) lithium aluminiumhy-dride in 30 ml dry THF. The reaction mixture is stirred at 0°C for additional 20 h. Water is added slowly to the mixture(0.914 ml in 20 min; T Example 106: trans-Toluene-4-sulfonic acid 3-[4-amino-5-(3-benzyloxy-phenyl)-6-methyl-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl ester 2.57 g (6.17 mmol) trans-{3-[4-amino-5-(3-benzyloxy-phenyl)-6-methyl-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutyl}-methanol of Example 105 aredissolved in 50 ml dry pyridine. The solution is cooled to ca. -25'C and 2.04 g (10.5 mmol) p-toluenesulfonyl chloride areadded in 4 portions. After stirring 3 h at -20°C and 24 h at 0-5X, additional p-toluenesulfonyl chloride (0.36 g; 1.85 mmol) is added and stirring is continued for additional 19 h. The reaction mixture is poured into ice-water and extracted with dichloromethane. The organic phase is washed with water and brine. After evaporating the organic solvent, the residue is purified by filtration on silicagel (ethyl acetate-hexane 3:1). The compound is dried at RT and under high-vacuum for 18 h. Analytical HPLC: tp = 4.12 min (shorty); ES-MS: m/eo = 569.2; NMR (DMS0-d6): 8.09/s(1H). 7.84/d (2H); 7.25-7.6/several m's(8H), 7.06/-d-(1H); 6.93/s(1H); 6.88/-d'(1H); 5.5-6.0/b (NH2); 5.13/s (2H); 5.00/m (1H); 4.26/d (2H); 3.15-3.35/m (2H); 2.69/m (1H); 2.42/s (3H); 2.17/s (3H); 2.42/s (3H); 2.05-2.20/m (2H). Example 107: trans-5-(3-Benzyloxy-phenyl)-6-methyl-7-(3-pyrrolidin-1-ylmethyl-cyclobutyl)-7H-pyrroIo[2,3-d]pyrimidin-4-ylamine 0.335 g (0.589 mmol) trans-toluene-4-sulfonic acid 3-[4-amino-5-(3-ben2yloxy-phenyl)-6-methyl-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl ester of Example 106 in 3.6 ml pyrrolidine arestirred at RT for 3.5 h (Thin Layer Chromatography and HPLC control). The excess reagent is evaporated on a rotavap and the residue purified by chromatography (sol- vent; ethyl acetate-MeOH-aqu. NH3 (33%) 95:5:1). The compound is crystallized from di-ethylether. Analytical HPLC: tR = 9.09 min (Grad 1); mp: 136-140X; ES-MS: m/eo = 468.3; NMR (DMS0-d6; not all signals reported): 8.10/s(1H), 7.25-7.5/several m's(6H). 7.02rd-(1H); 6.94/s(1H); 6.89rd-(1H); 5.5-6.0/b (NH2); 5.13/s (2H); 5.06/m (1H); 2.22/s (3H). Example 108: trans-5-(3-Benzyloxy-phenyl)-6-methyl-7-[3-(4-methyl-piperazin-1-ylmethyl)-cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine The title compound is obtained in analogy to Example 107 from 0.35 g (0.615 mmol) trans-toluene-4-sulfonic acid 3-[4-amino-5-(3-benzyloxy-phenyl)-6-methyl-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl ester and 3.5 ml (31.2 mmol) 1-methyl piperazine (RT; reaction time 24 h). Analytical HPLC: tp = 2.32 min (shorty); ES-MS: m/eo = 497.3; NMR (DMS0-d6; not all signals reported): 8.09/s(1H). 7.25-7.5/several m's(6H), 7.0ird-(1H); 6.94/s(1H); 6.89rd-(1H); 5.5-6.0/b (NH2); 5.13/s (2H); 5.07/m (1H); 2.22/s (3H); 2.13/s (3H). Example 109: trans-1-{3-[4-Amino-5-(3-benzyloxy-phenyl)-6-methyl-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl}-piperidin-4-ol The title compound is obtained in analogy to Example 107 from 0.35 g (0.615 mmol) trans-toluene-4-sulfonic acid 3-[4-amino-5-(3-benzyloxy-phenyl)-6-methyl-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl ester and a total of 0.44 g (4.3 mmol) 4-hydroxy piperidine in 3.5 ml of dry N.N-dimethyl acetamide (RT; 144 h; after 46 h 64 mg of reagent areadded to complete the reaction). Analytical HPLC: tR = 2.54 min (shorty); ES-MS: m/eo = 498.3; NMR (DMSO-d6; not all signals reported): 8.09/s(1H). 7.25-7.5/several m's(6H). 7.0ird-(1H); 6.94/s(1H); 6.89/-d-(1H); 5.5-6.0/b (NH2); 5.13/s (2H); 5.06/m (1H); 4.51/d (OH); 2.22/s (3H). Example 110: trans-7-(3-Azetidin-1-ylmethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-6-methyl-7H-pyrrolo[2.3-d]pyrimidin-4-ylamine The title compound is obtained in analogy to Example 107 from 0.35 g (0.65 mmol) trans-toluene-4-sulfonic acid 3-[4-amino-5-(3-benzyloxy-phenyl)-6-methyl-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl ester and 0.215 ml (3.08 mmol) trimethylenimin (Fluka, Buchs. Switzerland) in 3.5 ml N,N-dimethylacetamide (RT; reaction time 120 h). Analytical HPLC: IR = 8.97 min (Grad 1); ES-MS: m/eo = 454.3; NMR (DMS0-d6): 8.09/s(1H), 7.25-7.5/several m's(6H), 7.01/"d-(1H); 6.93/s(1H); 6.89rd-(1H); 5.5-6.0/b (NH2); 5.13/s (2H); 5.02/m (1H); ca. 3.3/m (1H); 3.2/m (2H); 3.10/t (2H); 2.54/d (2H); 2.30/m (1H); 2.21/s (3H); 2.11/m (2H); 1.94/m(2H). Example 111: trans-5-(3-Benzyloxy-phenyl)-6-methyl-7-{3-[(tetrahydro-pyran-4-ylamino)-methyl]-cyclobutyl}-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine The title compound is obtained in analogy to Example 107 from 0.35 g (0.62 mmol) trans-toluene-4-sulfonic acid 3-[4-amino-5-(3-benzyloxy-phenyl)-6-methyl-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl ester and 0.446 mg (4,42 mmol) tetrahydropyran-4-ylamin (obtained from tetrahydropyran-4-one oxime by hydrogenation) in 3.5 ml N,N-dimethylacetamide (RT; reaction time 310 h). Analytical HPLC: tp = 8.99 min (Grad 1); ES-MS; m/eo = 498.3; NMR (DMS0-d6; not all signals reported): 8.09/s(1H), 7.25-7.5/several m's(6H), 7.02rd*'(1H); 6,94/s(1H); 6.89rd-(1H); 5.5-6.0/b (NH2); 5.13/s (2H); 5.06/m (1H); 3.82/m (2H); 2.75/d (2H); 2.23/s (3H). Example 112: trans-((R)-1-{3-[4-Amino-5-(3-benzyloxy-phenyl)-6-methyl-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl}-pyrrolidin-2-yl)-methanol The title compound is obtained in analogy to Example 107 from 0.35 g (0.62 mmol) trans-toluene-4-sulfonic add 3-[4-amino-5-(3-benzyloxy-phenyl)-6-methyl-pyrrolo[2.3-d]pyrimidin-7'yl]-cyclobutylmethyl ester and 0.307 ml (3.08 mmol) D-prolinol (Fluka. Buchs, Switzerland) in 3.5 ml N,N-dimethylacetamide (RT; reaction time 114 h). Analytical HPLC: IR = 8.95 min (Grad 1); ES-MS: m/eo = 498.3; NMR (DMS0-d6; not all signals reported): 8.10/s(1H), 7.25-7.5/several m's(6H). 7.02/-d-(1H); 6.94/s(1H); 6.92/-d-(1H); 5.5-6.0/b (NH2); 5.13/s (2H); 5.06/m (1H); 4.37/bs (OH); 2.23/s (3H). Example 113: cis-3-[4-Amino-5-(3-benzyloxy-phenyl)-6-bromo-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutanecarboxylic acid methyl ester The title compound is prepared in analogy to Example 103 starting from 12.9 g (30.11 mmol) cis-3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutanecarboxylic acid methyl ester (see Step 3.1 above) and 6.07 g (33.12 mmol) N-bromosuccinimide in 250 ml dry N.N-dimethylformamide. After work-up, the raw material is purified by chromatography on silicagel (solvent: hexane-ethyl acetate 1:1), Analytical HPLC: tR =11.85 min (Grad 1); ES-MS: m/eo = 506.9 and 509.9; NMR (DMS0-d6): 8.14/s(1H), 7.3-7.5/several m's(6H). 7.09/-d-(1H); 7.05/s(1H); 6.98/-d-(1H); 5.5-6.5/b (NH2); 5.13/s (2H); 5.11/m (1H); 3.66/s (3H); 3.35-3.5/m (2H); 3.08/m (1H); 2.58.2.7/m (2H). Example 114: cis-3-[4-Amino-5-(3-benzyloxy-phenyl)-6-methyl-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutanecarboxylic acid methyl ester The title compound is prepared in analogy to Example 104 starting from 6.6 g (12.6 mmol) cis-3-[4-amino-5-(3-benzyioxy-phenyl)-6-bromo-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutane-carboxylic acid methyl ester of Example 113, 0.364 g (0.315 mmol) tetrakistriphenyl palladium, and 4.39 ml (31.52 mmol) tin tetramethyl (Fluka, Buchs, Switzerland) in 20 ml dry N,N-dimethylformamide (T=100-110°C , sealed tube; reaction time=25 h). Analytical HPLC: tR = 11.67 min (Grad 1); ES-MS: m/eo = 443.2; NMR (DMS0-d6; not all signals reported): 8.07/s(1H). 7.25-7.5/several m's(6H), 7.03rd-(1H); 6.95/s(1H); 6.90rd-(1H); 5.5-6.0/b (NH2); 5.14/s (2H); 4.90/m (1H); 3.65/s (3H); 2.25/s (3H). Example 115: cis-{3-[4-Amino-5-(3-benzyloxy-phenyl)-6-methyl-pyrrolo[2.3-d]pyrimidin-7-yl]- cyclobutyl}-methanol The title compound is obtained in analogy to Example 105 starting from 2.06 g cis-3-[4- amino-5-(3-benzyloxy-phenyl)-6-methyl-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutanecarboxylic acid methyl ester of Example 114 and 0.216 mmol lithium aluminiumhydride in 20 ml dry THF (T=0-5'C; reaction time 49 h). The product is purified by flash chromatography (solvent: ethyl acetate). Analytical HPLC: tR = 3.13 min (shorty); ES-MS: m/eo = 415.4; NMR (DMSO- d6): 8.07/s(1H). 7.25-7.5/several m's(6H). 7.02/-d-(1H); 6.94/s(1H); 6.89/-d-(1H); 5.5-6.0/b (NH2); 5.13/s (2H); 4.84/m (1H); 4.62/t (OH); 3.53/t (2H); 2.8-2.9/m (2H); 2.35-2.45/m (2H); 2.24/s(3H);2.2/m(1H). Example 116: cis-5-(3-Benzyloxy-phenyl)-6-methyl-7-(3-pyrrolidin-1-ylmethyl-cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine To a solution of 0.2 g (0.48 mmol) cis-{3-[4-amino-5-(3-benzyloxy-phenyl)-6-methyl-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutyl}-methanol of Example 115 in 2 ml dry pyridine cooled to ca. -25°C 0.159 g (0.96 mmol) p-toluenesulfonyl chloride areadded in 1 h in three portions. Stirring continued for 1 h at -20°C and overnight at 0°C . To this reaction mixture is added in 1 h under Argon 2 ml of pyrrolidine (T=0-5'°C ) and stirring is continued for additional 3 h. The reaction mixture is partitioned between ethyl acetate and water. After drying with sodium sulfate the solvent is evaporated and the residue purified by flash chromatography (solvent: ethyl acetate-MeOH-NHa aqu. (33%) 95:5:1). Analytical HPLC: tR = 9.28 min (Grad 1); ES-MS: m/eo = 468.2; NMR (DMS0-d6): 8.08/s(1H), 7.25-7.5/several m's(6H), 7.02rd-(1H); 6.94/s(1H); 6.89rd-(1H); 5.4-5.9/b (NH2); 5.13/s (2H); 4.77/m (1H); 2.8-2.9/m (2H); 2.60/d (2H); 2.35-ca.2.5/m (6H); 2.23/s (3H); ca. 2.15-2.25/m (1H); 1.6-1.7/m (4H). Example 117: cis-5-(3-Benzyloxy-phenyl)-6-methyl-7-(3-(4-methyl-piperazin-1-ylmethyl)-cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine The title compound is prepared in a one pot reaction in analogy to Example 116 starting from 0.35 g (0.84 mmol) cis-{3-[4-amJno-5-(3-ben2yloxy-phenyl)-6-methyl-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutyl}-methanol and 0.328 g (1.69 mmol) p-toluenesulfonyl chloride in 3.5 ml dry pyridine, followed by 3.5 ml (31.2 mmol) 1-methyl piperazine. Analytical HPLC: tR = 8.14 min (Grad 1); ES-MS: m/eo = 497.3; NMR (DMS0-d6; not all data reported): 8.08/s(1H), 7.25-7.45/several m's(6H), 7.02/-d-(1H); 6.94/s(1H); 6.89rd-(1H); 5.4-6.0/b (NH2); 5.13/s (2H); 4.77/m (1H); 2.22/s (3H); 2.12/s (3H). Example 118: cis-7-(3-Azetidin-1-ylmethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-6-methyl-7H-pyrro!o[2,3-d]pyrimidin-4-ylamine The title compound is prepared in analogy to Example 116 starting from 0.35 g (0.84 mmol) cis-{3-[4-amino-5-(3-benzyloxy-phenyl)-6-methyl-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutyl}-methanol and 0.328 g (1.69 mmol) p-toluenesulfonyl chloride in 3.5 ml dry pyridine, followed by 0.442 ml (6.33 mmol) trimethylenimine (Fluka, Buchs, Switzerland). Analytical HPLC: IR = 9.22 min (Grad 1); ES-MS: m/eo = 454.3; NMR (DMS0-d6): 8.08/s(1H), 7.25-7.5/several m*s(6H), 7.02/-d-(1H); 6.93/s(1H); 6.89rd-(1H); 5.4-6.0/b (NH2); 5.13/s (2H); 4.76/m (1H); 3.1irr (4H); 2.75-2.90/m (2H); 2.54/d (2H); 2.35-2.45/m (2H); 2.22/s (3H); 2.03/m (1H); 1.9-2.0/m (2H). Example 119: cis-1-{3-[4-Amino-5-(3-benzyloxy-phenyl)-6-methyl-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-piperidin-4-ol The title compound is prepared in analogy to Example 116 starting from 0.35 g (0.84 mmol) cis-{3-[4-amino-5-(3-benzyloxy-phenyl)-6-methyl-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutyl}-methanol and 0.328 g (1.69 mmol) p-toluenesulfonyl chloride in 3.5 ml dry pyridine, followed by 0.87 g (8.44 mmol) 4-hydroxypiperidine (Fluka, Buchs, Switzerland). Analytical HPLC: tR = 8.76 min (Grad 1); ES-MS: m/eo = 498.2; NMR (DMS0-d6; not all signals reported): 8.07/s(1H). 7.25-7.5/several m's(6H), 7.01/-d-(1H); 6.94/s(1H); 6.89rd-(1H); 5,13/s (2H); 4.76/m (1H); 4.51/d (OH); 2.22/s (3H). Example 120: cis-((R)-1-{3-[4-Amino-5-(3-benzyloxy-phenyl)-6-methyl-pyn'olo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl}-pyrrolidin-2-yl)-methanol The title compound is prepared in analogy to Example 116 starting from 0.35 g (0.84 mmol) cis-{3-[4-amino-5-(3-ben2yloxy-phenyl)-6-methyl-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutyl}-methanol and 0.328 g (1.69 mmol) p-toluenesulfonyl chloride in 3.5 ml dry pyridine, followed by 0.631 ml (6.33 mmol) D-prolinol (Fluka, Buchs, Switzerland). Analytical HPLC: tp = 9.08 min (Grad 1); ES-MS: m/eo = 498.2; NMR (DMS0-d6; not all signals reported): 8.07/s(1H), 7.25-7.5/several m's(6H). 7.02rd-(1H); 6.94/s(1H); 6.89/-d-(1H); 5.4-6.0/b (NH2); 5.13/s (2H); 4.78/m (1H); 4.34/b (OH); 2.22/s (3H). Example 121: 5-(3-Benzyloxy-phenyl)-6-bromo-7H-pyrrolo[2.3-d]pyrimidin-4-ylamine To a solution of 20 g (63.2 mmol) 5-(3-benzyloxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine (see WO 97/28161) in 1 I dry N,N-dimethylformamide, 12.4 g (69.5 mmol) N-bromosuccinimide areadded at ca. lO^'C. Stirring was continued at ca. 10*^0 for 30 min and overnight at RT. The precipitate formed is filtered off and washed thoroughly with N.N-dimethylformamide and hexane. After drying for 24 h at 30-35'C under vacuum, the title compound is used in the next step without further purification. Additinonal material can be obtained from the mother liquor through chromatography on silicagel. Analytical HPLC: IR = 10.07 min (Grad 1); ES-MS: m/eo = 394.9 and 396.9; NMR (DMSO-d6): 12.55/s (NH); 8.06/s(1H). 7.25-7.5/several m*s(6H). 7.07rd-(1H); 7.03/s(1H); 6.98rd-(1H); 5.5-6.0/b (NH2);5.12/s(2H). Example 122: 5-(3-Benzyloxy-phenyl)-6-ethyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine In a sealed tube 12.53 g (31.7 mmol) 5-(3-benzyloxy-phenyl)-6-bromo-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine, 32 ml (158.5 mmol) tin tetraethyl (Aldrich), and 7.32 g (6.34 mmol) tetrakis triphenylphosphin palladium areheated under Argon at 90°C for 66 h (reaction control by HPLC and MS). After that time, the reaction suspension is filtered on hyflo and the solvent evaporated on a rotavap under high vacuum at 50-60°C . The residue is partitioned between ethyl acetate and water. The organic phase is dried over sodium sulfate and is evaporated. The residue is purified by chromatography on silicagel (ethyl acetate-methanol 95:5). Crystallization is done from acetone. Analytical HPLC: tp = 10.43 min (Grad 1); ES-MS: m/eo = 345.1; NMR (DMS0-d6): 11.65/s (NH); 8.03/s(1H), 7.25-7.5/m and 6.85-7.1/m (9H), 5.5-6.0/b (NH2); 5.14/s (2H); 2.54/q (2H); 1.14/s (3H). Example 123: cis and trans-3-[4-Amino-5-(3-benzyloxy-phenyl)-6-ethyl-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutanecarboxylic acid methyl ester A mixtureof 1.26 g (2.74 mmol) 5-(3-benzyloxy-phenyl)-6-ethyl-7H'pyrrolo[2,3-d]pyrimidin-4-ylamine, 1.53 g (10.9 mmol) of powdered potassium carbonate and 2.92 g (10.9 mmol) 18-crown-6 ether in 12 ml dry N,N-dimethylformamide is stirred for 15 min at 80°C. 1.7 g (8.2 mmol) of 3-Methanesulfonyloxy-cyclobutanecarboxylic acid methyl ester, dissolved in 9 ml dry N.N-dimethylformamide, is added dropwise in 15 min. After stirring for 42 h at 80'*C. work-up is effected by filtering the reaction mixtureon hyflo and evaporating the solvent. The residue is partitioned between water and ethyl acetate. The organic layer is dried over sodium sulfate and concentrated in vacuo. The crude product is purified and separated by flash chromatography (hexane-ethyl acetate 1:2). The ratio cis to trans isomer is about 70:30 (by HPLC, Grad25). cis: Analytical HPLC: tp = 12.27 min (Grad 1); ES-MS: m/eo = 457.0; NMR (DMS0-d6): 8.12/s(1H). 7.3-7.5/several m's(6H). 7.07/-d-(1H); 6.96/s(1H); 6.91/"d-(1H); 5.5-6.1/b (NH2); 5.15/s (2H); 4.81/m (1H); 3.67/s (3H); 3.49/q (2H); 3.03/m (1H); 2.62/m (4H); 1.08/t (3H). trans: Analytical HPLC: tp = 12.65 min (Grad 1); ES-MS: m/eo = 457.0; NMR (DMSO-d6): 8.37/s(1H); 7.3-7.5/several m's(6H), 7.11/-d'(1H); 6.97/s(1H); 6.93/-d-(1H); 5.15/s (2H); 5.11/m (1H); 3.70/s (3H); 3.3-3.5/m (3H); 2.72/m (2H); 2.62/q (2H); 1.06/t (3H); NH2 not visible. Example 124: cis-{3-[4-Amino-5-(3-benzyloxy-phenyl)-6-ethyl-pyrroio[2,3-d]pyrimidin-7-yl]-cyclobutyl}-methanol In analogy to Example 105, 0.73 g (1.56 mmol) cis-3-[4-amino-5-(3-benzyloxy-phenyl)-6-ethyl-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutanecarboxylic acid methyl ester of Example 123 arereduced with 69 mg (1.73 mmol) lithium aluminiumhydride in THF. Reaction time: 18 h at 0-5oC . Analytical HPLC: tp = 11.15 min (Grad 1); ES-MS: m/eo = 429.1; NMR (DMS0-d6): 8.10/s(1H); 7.3-7.5/several m's(6H), 7.04/-d-(1H); 6.93/s(1H); 6.90/-d*'(1H); 5.4-6.0/b (NH2); 5.15/s (2H); 4.75/m (1H); 4.63/T (OH); 3.60/t (2H); 3.03q (2H); 2.61/q (2H); 2.14/q (2H); 2.24/m(1H); 1.07/t(3H). Example 125: trans-{3-[4-Amino-5-(3-ben2yloxy-phenyl)-6-ethyl-pyrrolo[2,3-d]pyrimidin-7-yl]- cyclobutyl}-methanol In analogy to Example 105, 0.49 g (1.09 mmol) trans-3-[4-amino-5-(3-benzyloxy-phenyl)-6- ethyl-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutanecarboxylic acid methyl ester of Example 123 arereduced with 46 mg (1.18 mmol) lithium aluminiumhydride in THF. Reaction time: 17 h at 0-5°C. Analytical HPLC: tp = 10.91 min (Grad 1); ES-MS: m/eo = 429.1; NMR (DMSO-d6): 8.13/s(1H); 7.3-7.6/several m's(6H). 7.06rd-(1H); 6.95/s(1H); 6.90rd-(1H); 5.4-6.0/b (NH2); 5.15/s (2H); 4.93/m (1H); 4.68/T (OH); 3.60/m (2H); ca. 3.3-3.4/m (2H); 2.95/q (2H); 2.20/m (2H);2.24/m(1H);1.05/t(3H). Example 126: cis-5-(3-Benzyloxy-phenyl)-6-ethyl-7-(3-pyrrolidin-1-ylmethyl-cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine The title compound is prepared in a one pot reaction in analogy to Example 116 starting from 0.2 g (0.46 mmol) cis-{3-[4-amino-5-(3-benzyloxy-phenyl)-6-ethyl-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutyl}-methanol of Example 124 and 0.18 g (0.92 mmol) p-toluenesulfonyl chloride in 2 ml dry pyridine followed by 2 ml pyrrolidine. The reaction is controlled by tic. Analytical HPLC: tR = 9.61 min (Grad 1); ES-MS: m/eo = 482.0; NMR (DMS0-d6; not all signals reported): 8.12/s(1H); 6.'9-7.5/several m's(6H), 7.05rd-(1H); 6.95/s(1H); 6.92rd-(1H); 5.4-6.0/b (NH2); 5.15/s (2H); 4.72/m (1H); 2.62/q (2H); 1,06/t (3H). Example 127: cis-5-(3-Benzyloxy-phenyl)-6-ethyl-7-[3-(4-methyl-piperazin-1-ylmethyl)- cyciobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine The title compound is prepared in analogy to Example 116 from cis-{3-[4-amino-5-(3- benzyloxy-phenyl)-6-ethyl-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutyl}-methanol of Example 124. p-toluenesulfonyl chloride and N-methylpiperazine. Analytical HPLC-MS: tp = 1.40 min (Grad 1); ES-MS: m/eo = 511.45. Example 128: cis-7-(3-Azetidin-1-vlmethvl-cvclobutvl)-6-ethvl-5-(3'f(Z)-2-eth-(E)-vlidene-hexa-3,5-dienyloxy]-phenyl}-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine The title compound is prepared in analogy to Example 116 from cis-{3-[4-amino-5-(3-benzyloxy-phenyl)-6-ethyl-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutyl}-methanol of Example 124, p-toluenesulfonyl chloride and trimethylenimin (Fluka, Buchs. Switzeriand), Analytical HPLC-MS: tp = 1.51 min; ES-MS: m/eo = 468.45. Example 129: cis-1-(3-[4-Amino-5-(3-benzyloxy-phenyl)-6-ethyl-pyrrolo[2,3-d]pyrimidin-7-yl]- cyclobutylmethyl}-piperidin-4-ol The title compound is prepared in analogy to Example 116 from cis-{3-[4-amino-5-(3- benzyloxy-phenyl)-6-ethyl-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutyl}-methanol of Example 124, p-toluenesulfonyl chloride and 4-hydroxypiperidine (Fluka. Buchs, Switzerland). Analytical HPLC-MS: IR = 1.49 min; ES-MS: m/eo = 512.48. Example 130: cis-((R)-1-{3-[4-Amino-5-(3-benzyloxy-phenyl)-6-ethyl-pyrrolo[2,3-d]pyrimidin- 7-yl]-cyclobutylmethyl}-pyrrolidin-2-yl)-methanol The title compound is prepared in analogy to Example 116 from cis-{3-[4-amino-5-(3- benzyloxy-phenyl)-6-ethyl-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutyl}-methano! of Example 124, p-toluenesulfonyl chloride and D-prolinol (Fluka, Buchs. Switzerland). Analytical HPLC-MS: tR = 1.48 min; ES-MS: m/eo = 512.48. Example 131: cis-5-(3-Benzyloxy-phenyl)-6-ethyl-7-{3-[(tetrahydro-pyran-4-ylamino)-methyl]- cyclobutyl}-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine The title compound is prepared in analogy to Example 116 from cis-{3-[4-amino-5-(3- ben2yloxy-phenyl)-6-ethyl-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutyl}-methanol of Example 124, p-toluenesulfonyl chloride and teztrahydropyran-4-ylamin (see Example 111). Analytical HPLC-MS: tR = 1.50 min; ES-MS: m/eo = 512.49. Example 132: Test for activity against IGF-I induced IGF-IR autophosphorylation using the cellular -CaptureELISA- test The cellular -CaptureELISA- test is carried out as described above. The IC50 values for some of the compounds of the present invention aregiven below: Compound from Example IC50 (µM) 1 0.062 2 0.03 9 0.042 10 0.07 14 0.03 22 0.08 23 0.031 24 0.095 26 0.055 27 0.05 28 0.05 31 0.03 49 0.04 50 0.011 51 0.03 57 0.018 70 0.05 75 0.05 77 0.05 81 0.08 83 0.052 88 0.057 90 0.09 95 0.08 96 0.05 98 0.04 102 0.06 109 0.15 110 0.14 112 0.09 116 0.15 117 0.13 Example 133: Tablets Tablets comprising 50 mg of active ingredient, for example one of the compounds of formula I described in Examples 1 to 131, and having the following composition areprepared in customary manner: Composition: active ingredient 50 mg wheat starch 150 mg lactose 125 mg colloidal silicic acid 12.5 mg talc 22.5 mg magnesium stearate 2.5 mg Total: 362.5 mg Preparation: The active ingredient is mixed with a portion of the wheat starch, with the lactose and the colloidal silicic acid and the mixture is forced through a sieve. A further portion of the wheat starch is made into a paste, on a water bath, with five times the amount of water and the powder mixture is kneaded with the paste until a slightly plastic mass is obtained. The plastic mass is pressed through a sieve of about 3 mm mesh size and dried, and the resulting dry granules areagain forced through a sieve. Then the remainder of the wheat starch, the talc and the magnesium stearate aremixed in and the mixture is compressed to form tablets weighing 145 mg and having a breaking notch. Example 134: Soft Capsules 5000 soft gelatin capsules comprising each 50 mg of active ingredient, for example one of the compounds of formula I described in Examples 1 to 131, areprepared in customary manner: Composition: active ingredient 250 g Lauroglykol 2 litres Preparation: The pulverized active ingredient is suspended in Lauroglykol® (propylene glycol laurate, Gattefosse S.A., Saint Priest. France) and ground in a wet pulverizer to a particle size of approx. 1 to 3µm. 0.419 g portions of the mixturearethen dispensed into soft gelatin capsules using a capsule-filling machine. Claims: 1. A compound of formula 1 wherein n is from 0 to 4, R1 is hydrogen, unsubstituted or substituted lower alkyl or halogen. R2 is lower alkyl substituted by hydroxy, unsubstituted. mono- or disubstituted amino or by a heterocyclic radical; a radical R5-(C=Y)-Z-. wherein R5 is unsubstituted or substituted lower alkyl, unsubstituted. mono- or disubstituted amino, a heterocyclic radical, or free or etherified hydroxy. Y is oxygen, sulfur or imino, and Z is either not present, lower alkyl or amino-lower alkyl; or a radical R6-sulfonylamino-lower alkyl. wherein R6 is unsubstituted or substituted lower alkyl. unsubstituted. mono- or disubstituted amino or phenyl optionally substituted by lower alkyl, lower alkoxy or nitro. with the proviso that R2 is not carboxy, lower alkoxycar-bonyl or lower alkyl substituted by hydroxy if n is 0. R7 is hydrogen. R4 is benzyl and X is -O-. R3 is lower alkyl. hydroxy-, amino- or halogen-substituted lower alkyl, hydroxy, cyano. lower alkoxy. lower alkanoyl. lower alkanoyloxy. amino, mono- or di-lower alkylamino. lower alka-noylamino. carboxy. lower aikoxycarbonyl or halogen, wherein the R3 substituents can be selected independently of one another if n>1, R4 is a radical R7-CR8(R9)-, wherein R7 is cyclobutyl, cyclopentyl, cyclohexyl. phenyl, furyl, pyrrolyl, thienyl or pyridyl. said R7 substitutents being optionally substituted by one or more radicals selected from lower alkyl and halogen, and R6 and R9 are independently of each other hydrogen, lower alkyl or halogen, and X is selected from -O-, -NH- and -S-, or a salt thereof. 2. A compound of formula I according to claim 1, wherein n is from 0 to 4, R1 is hydrogen, unsubstituted or substituted lower alkyl or halogen. R2 is lower alkyl substituted by hydroxy, unsubstituted, mono- or disubstituted amino or by a heterocyclic radical; a radical R5-(C=Y)-Z-, wherein R5 is unsubstituted or substituted lower alkyl. unsubstituted. mono- or disubstituted amino, a heterocyclic radical, or free or etherified hydroxy. Y is oxygen, sulfur or imino. and Z is either not present, lower alkyl or amino-lower alkyl; or a radical R6-sulfonylamino-lower alkyl. wherein Re is unsubstituted or substituted lower alkyl. unsubstituted. mono- or disubstituted amino or phenyl optionally substituted by lower alkyl, lower alkoxy or nitro, with the proviso that R2 is not carboxy, lower alkoxycar-bonyl or lower alkyl substituted by hydroxy if n is 0. R1 is hydrogen, R4 is benzyl and X is -0-, R3 is lower alkyl or lower alkoxy. wherein the R3 substituents can be selected independently of one another if n>1, R4 is a radical R7-CR8CRg)-. wherein R7 is cydobutyl, cyclopentyl. cyclohexyl, phenyl, furyl. pyrrolyl. thienyl. pyridyl or phenyl substituted by one or more substitutents selected from lower alkyl and halogen, and R8 and R9 are independently of each other hydrogen, lower alkyl or halogen, and X is selected from -O-, -NH- and -S-, or a salt thereof. 3. A compound of formula I according to claim 1. wherein n is 0, R1 is hydrogen, unsubstituted or substituted lower alkyl or halogen, R2 is lower alkyl substituted by unsubstituted, mono- or disubstituted amino or by a heterocyclic radical; a radical R5-(C=Y)-Z-, wherein R5 is unsubstituted or substituted lower alkyl, unsubstituted, mono- or disubstituted amino, a heterocyclic radical, or if Z is present is also free or etherified hydroxy, Y is oxygen, sulfur or imino. and Z is either not present, lower alkyl or amino-lower alkyl; or a radical Re-sulfonylamino-lower alkyl, wherein R6 is unsubstituted or substituted lower alkyl, unsubstituted, mono- or disubstituted amino or phenyl optionally substituted by lower alkyl, lower alkoxy or nitro, R4 is benzyl, and X is selected from -O-, -NH- and -S-, or a salt thereof. 4. A compound of formula I according to claim 3, wherein n is O, R1 is hydrogen, unsubstituted or substituted lower alkyl or halogen, R2 is lower alkyl substituted by a substituted heterocyclic radical; a radical R5-(C=Y)-Z-, wherein R5 is unsubstituted or substituted lower alkyl, unsubstituted, mono- or disubstituted amino, a heterocyclic radical, or if Z is present is also free or etherified hydroxy, Y is oxygen, sulfur or imino, and Z is either not present, lower alkyl or amino-lower alkyl, with the proviso that Z is not present or lower alkyl if R5 is lower alkyl and Z is lower alkyl or amino-lower alkyl if R5 is mono- or disubstituted amino or a heterocyclic radical; or a radical R6-sulfonylamino-lower alkyl. wherein R6 is unsubstituted or substituted lower alkyl, unsubstituted, mono- or disubstituted amino or phenyl optionally substituted by lower alkyl, lower alkoxy or nitro, R4 is benzyl, and X is selected from -O-, -NH- and -S-. or a salt thereof. 5. A compound of formula I according to claim 3, wherein n is 0, R1 is hydrogen, unsubstituted or substituted lower alkyl or halogen, R2 is lower alkyl substituted by amino, N-lower alkylamino, N,N-di-lower alkylamino or by an unsubstituted heterocyclic radical; or a radical R5-(C=Y)-Z-, wherein R5 is lower alkyl. mono-or disubstituted amino or a heterocyclic radical. Y is oxygen, sulfur or imino, and Z is amino-lower alkyl if R5 is lower alkyl and not present if R5 is a heterocyclic radical or mono- or disubstituted amino, R4 is benzyl, and X is selected from -O-, -NH- and -S-, or a salt thereof. 6. A compound of formula I according to claim 3, wherein n is O, R1 is hydrogen, unsubstituted or substituted lower alkyl or halogen. R2 is lower alkyl substituted by unsubstituted, mono- or disubstituted amino or by a heterocyclic radical having from 4 to 8 ring members and from 1 to 3 heteroatoms whereby at least one heteroatom is nitrogen and the binding of the heterocyclic radical to lower alkyl occurs via a nitrogen ring atom; a radical R5-(C=Y)-Z-, wherein R5 is lower alkyl, unsubstituted, mono- or disubstituted amino, a heterocyclic radical having from 4 to 8 ring members and from 1 to 3 heteroatoms whereby at least one heteroatom is nitrogen and the binding of the heterocyclic radical occurs via a nitrogen ring atom, lower alkyl substituted by said heterocyclic radical or by one or more radicals selected independently of one another from the group consisting of amino, N-lower alkylamino. N.N-di-lower alkylamino, N-lower alka-noylamino, N.N-di-lower alkanoylamino, hydroxy, lower alkoxy, ioweralkoxy-loweralkoxy, lower alkanoyl, lower alkanoyloxy, cyano. nitro, carboxy, lower alkoxycarbonyl, carbamoyl, amidino, guanidino, ureido. mercapto. lower alkylthio and halogen, or if Z is present is also free or etherified hydroxy. Y is oxygen, sulfur or imino, and Z is either not present, lower alkyl or amino-lower alkyl; or a radical R6-sulfonylamino-lower alkyl, wherein R6 is unsubstituted or substituted lower alkyl. unsubstituted. mono- or disubstituted amino or phenyl optionally substituted by lower alkyl, lower alkoxy or nitro. R4 is benzyl, and X is selected from O0-, -NH- and -S-, or a salt thereof. 7. A compound of formula I according to claim 3. wherein n is O. R1 is hydrogen, R2 is amino-lower alkyl. N-lower alkylamino-lower alkyl. N,N-di-lower alkylamino-lower alkyl, morpholinyl-lower alkyl, piperidyl-lower alkyl. pyrrolidinyl-lower alkyl, lower alkyl-piperazinyl-lower alkyl, adamantanyl-amino-lower alkyl, hydroxy-piperidyl-lower alkyl. azepanyl-lower alkyl. di-lower alkyl-pyn-olidinyl-lower alkyl, azetidinyl-lower alkyl, aminocarbonyl-piperidyl-lower alkyl, pyridyl-piperazinyl-lower alkyl, thiomorpholinyl-lower alkyl, di-lower alkyl-morpholinyl-lower alkyl, aminocarbonyl-pyrrodinyl-lower alkyl. lower alkoxycarbonyl-piperazinyl-lower alkyl or phenyl-piperazinyl-lower alkyl; a radical R5-(C=Y)-Z-. wherein R5 is lower alkyl, amino, N-lower alkylamino, N,N-di-lower alkylamino, N-(phenyl-lower alkylamino, N-(lower alkyl-phenyl-lower alkyl)-amino, N-(lower alkoxy-phenyl-lower alkyl)-amino, N-(morpholinyl-lower alkyl)-amino, N,N-di-lower alkylamino-lower alkylamino. pyrrolidlnyl, piperidyl. morpholinyl, lower alkyl-piperazinyl. piperidyl-lower alkyl, morpholinyl-lower alkyl, lower alkyl-piperazinyl-lower alkyl, lower alkoxy, lower alkoxy-lower alkoxy, lower alkoxy-lower alkyl, lower alkoxy-lower alkoxy-lower alkyl. N.N-di-lower alkylamino-lower alkoxy, morpholinyl-lower alkoxy or lower alkyl-piperazinyl-lower alkoxy, Y is oxygen or imino, and Z is is either not present or amino-lower alkyl; or a radical R6-sulfonylamino-lower alkyl, wherein R6 is lower alkyl, lower alkyl-phenyl, lower alkoxy-phenyl, nitrophenyl or N,N-di-lower al- kylamino, R4 is benzyl, and X is -O-, or a salt thereof. 8. A compound of fornnula I according to claim 1, wherein n is O, R1 is hydrogen, lower alkyl or halogen. R2 is a radical selected from the group consisting of hydroxy-lower alkyl, carboxy, lower alkoxycarbonyl, amino-lower alkyl, N-lower alkylamino-lower alkyl, (tetrahydropyranyl-amino)-lower alkyl, N,N-di-lower alkylamino-lower alkyl, N-lower alkylaminocarbonyl. N,N-di-iower alkylaminocarbonyl, guanidino-lower alkyl, lower alkyl-sulfonylamino-lower alkyl, lower alkoxy-phenyl-sulfonylamino-lower alkyl, lower alkyi-phenyl-sulfonylamino-lower alkyl, nitro-phenyl-sulfonylamino-lower alkyl, N,N-di-lower alkylamino-sulfonylamino-lower alkyl, lower alkoxycarbonylamino-lower alkyl. lower alkoxy-lower alkoxycarbonylamino-lower alkyl. ureido-lower alkyl, N-lower alkylamino-carbonylamino-lower alkyl, N,N-di-lower alkylamino-carbonylamino-lower alkyl, N-(phenyl-lower alkyl)-amino-carbonylamino-lower alkyl, N-(lower alkyl-phenyl-lower alkyl)-amino-carbonylamino-lower alkyl, N-(lower alkoxy-phenyl-lower al-kyl)-amino-carbonylamino-lower alkyl, N-(morpholinyl-lower alkyl)-amino-carbonylamino-lower alkyl, N,N-di-lower alkylamino-lower alkylamino-carbonylamino-lower alkyl, lower alkyl-carbonylamino-lower alkyl, piperidyMower alkylcarbonylamino-lower alkyl, morpholinyl-lower alkylcarbonylamino-lower alkyl, lower alkyl-piperazinyl-lower alkylcarbonylamino-lower alkyl, morpholinyl-lower alkyl, piperidyl-lower alkyl. pyrrolidinyl-lower alkyl, [(hydroxy-lower alkyl)-pyrrolidinyl]-lower alkyl, lower alkyl-piperazinyl-lower alkyl. adamantanyl-amino-lower alkyl, hydroxy-piperidyl-lower alkyl. azepanyl-lower alkyl. di-lower alkyl-pyrrolidinyNower alkyl. azetidinyl-lower alkyl, aminocarbonyl-piperidyl-lower alkyl, pyridyl-piperazinyl-lower alkyl. thiomorpholinyl-lower alkyl. di-lower alkyl-morpholinyl-lower alkyl, aminocarbonyl-pyrrodinyl-lower alkyl, lower alkoxycarbonyl-piperazinyl-lower alkyl. phenyl-piperazinyl-lower alkyl, lower alkoxy-lower alkylcarbonylamino-lower alkyl. lower alkoxy-lower alkoxy-lower alkylcarbonylamino-lower alkyl. pyrrolidinyl-carbonylamino-lower alkyl. piperidyl-carbonylamino-lower alkyl. morpholinyl-carbonylamino-lower alkyl, lower alkyl-piperazinyl-carbonylamino-lower alkyl, N,N-di-lower alkylamino-lower alkoxycarbonylamino-lower alkyl, morpholinyl-lower alkoxy- carbonylamino-lower alkyl and lower alkyl-piperazinyl-lower alkoxycarbonylamino-lower alkyl, with the proviso that R2 is not hydroxy-lower alkyl. carboxy or lower alkoxycarbonyl if R^ is hydrogen, R4 is benzyl, and X is -O-, or a salt thereof. 9. A compound of formula I according to claim 3. wherein n is O. R1 is hydrogen, R2 is a radical selected from the group consisting of amino-lower alkyl, N-lower alkylamino-lower alkyl, N.N-di-lower alkylamino-lower alkyl, N-lower alkylaminocarbonyl, N,N-di-lower alkylaminocarbonyl, guanidino-lower alkyl, lower alkyl-sulfonylamino-lower alkyl. lower alkoxy-phenyl-sulfonylamino-lower alkyl. lower alkyl-phenyl-sulfonylamino-lower alkyl, nitro-phenyl-sulfonylamino-lower alkyl. N,N-di-lower alkylamino-sulfonylamino-lower alkyl, lower alkoxycarbonylamino-lower alkyl, lower alkoxy-lower alkoxycarbonylamino-lower alkyl. ureido-lower alkyl, N-lower alkylamino-carbonylamino-lower alkyl, N,N-di-lower alkylamino-carbonylamino-lower alkyl, N-(phenyl-lower alkyl)-amino-carbonylamino-lower alkyl, N-(lower alkyl-phenyl-lower alkyl)-amino-carbonylamino-lower alkyl. N-(lower alkoxy-phenyl-lower al-kyl)-amino-carbonylamino-lower alkyl, N-(morpholinyl-lower alkyl)-amino-carbonylamino-lower alkyl, N,N-di-lower alkylamino-lower alkylamino-carbonylamino-lower alkyl, lower alkyl-carbonylamino-lower alkyl, piperidyl-lower alkylcarbonylamino-lower alkyl, morpholinyl-lower alkylcarbonylamino-lower alkyl. lower alkyl-piperazinyl-lower alkylcarbonylamino-lower alkyl, morpholinyl-lower alkyl. piperidyl-lower alkyl, pyrrolidinyl-lower alkyl. lower alkyl-piperazinyl-lower alkyl, adamantanyl-amino-lower alkyl. hydroxy-piperidyl-lower alkyl, azepanyl-lower alkyl, di-lower alkyl-pyrrolidinyl-lower alkyl, azetidinyl-lower alkyl, aminocarbonyl-piperidyl-lower alkyl. pyridyl-piperazinyl-lower alkyl, thiomorpholinyl-lower alkyl, di-lower alkyl-morpholinyl-lower alkyl, aminocarbonyl-pyrrodinyl-lower alkyl, lower alkoxycarbonyl-piperazinyl-lower alkyl, phenyl-piperazinyl-lower alkyl, lower alkoxy-lower alkylcarbonylamino-lower alkyl, lower alkoxy-lower alkoxy-lower alkylcarbonylamino-lower alkyl, pyrrolidinyl-carbonylamino-lower alkyl, piperidyl-carbonylamino-lower alkyl, morpholinyl-carbonylamino-lower alkyl, lower alkyl-piperazinyl-carbonylamino-lower alkyl, N,N-di-lower alkylamino-lower alkoxycarbonylamino-lower alkyl. morpholinyl-lower alkoxycarbonylamino-lower alkyl and lower alkyl-piperazinyl-lower alkoxycarbonylamino-lower alkyl, R4 is benzyl, and X is -O-. or a salt thereof. 10. A compound of formula I according to claim 3. selected from the group consisting of cis-7-(3-aminomethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2.3-d]pyrimidin-4- ylamine; trans-7-(3-aminomethyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4- ylamine; cis-3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutanecarboxylic acid dimethylamide; trans-3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutanecarboxylic acid dimethylamide; ds-3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutanecarboxylic acid methylamide; trans-3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutanecarboxylic acid methylamide; cJs-5-(3-benzyloxy-phenyl)-7-(3-dimethylaminomethyl-cyclobutyl)-7H-pyrrolo[2.3-d]pyrimidin- 4-ylamine; trans-5-(3-benzyloxy-phenyl)-7-(3-dimethylaminomethyl-cyclobutyl)-7H-pyrrolo[2,3- d]pyrimidin-4-ylamine; cis-5-(3-benzyloxy-phenyl)-7-(3-methylaminomethyl-cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-4- ylamine; trans-5-(3-benzyloxy-phenyl)-7-(3-methylaminomethyl-cyclobutyl)-7H-pyrrolo[2.3-d]pyrimidin- 4-ylamine; trans-N-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}- guanidine; cis-N-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl}- guanidine; trans-N-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}- methanesulfonamide; cis-N-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}- methanesulfonamide; trans-N-{3-[4-amino-5-(3-benzy!oxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl^^^ methoxy-benzenesulfonamide; trans-N-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-4- methyl-benzenesulfonamide; trans-N-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl^ nitro-benzenesulfonamide; propane-2-sulfonic acid trans-(3-[4-amino-5-(3-benzyloxy'phenyl)-pyrrolo[2,3-d]pyrimidin-7- yl]-cyclobutylmethyl}-amide; ethanesulfonic acid trans-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]- cyclobutylmethyl}-amide; N-dimethyl-sulfamide trans-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]- cyclobutylmethyl}-amide; N-dimethyl-sulfamide cis-{3-[4-amino-5-(3-benzyloxy-phenylVpyrrolo[2.3-d]pyrimidin-7-yl]- cyclobutyImethyl}-amide; trans-{3-[4-amino-5-(3-benzy!oxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}- carbamic acid methyl ester; cis-{3-[4"amino-5-(3-benzyloxy-phenyi)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}- carbamic acid methyl ester; trans-{3-[4-amino-5-(3-benzyIoxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl}- carbamic acid 2-methoxy-ethyl ester; cis-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}- carbamic acid 2-methoxy-ethyl ester; trans-1-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cydobutylmethyl}-3- ethyl-urea; cis-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-3- ethyl-urea; trans-1-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cycIobutylmethyl}-3- propyl-urea; cis-1-{3-{4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutyImethyl}-3- propyl-urea; trans-1-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-3- isopropyl-urea; cis-1-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-3- isopropyl-urea; trans-1-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethy^ butyl-urea; cis-1-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pynmidin-7-yl]-cyclobutylmethyl}-3-butyl-urea; trans-1-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-3-tert-butyl-urea; cis-1-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrirnidin-7-yl]-cyclobutylmethyl}-3-tert-butyl-urea; trans-1-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-3-benzyl-urea; trans-1-{3-[4-arnino-5-(3-ben2yloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-3-(3-methyl-benzyl)-urea; cis-1-{3-[4-amino-5-(3--benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-3-(3-methyl-benzyl)-urea; cis-1-{3-[4-arnino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyriniidin-7-yl]-cyclobutylnriethyl}-3-(^^ methoxy-benzyl)-urea; trans-1-{3-[4-aniino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-3- (2-morpholin-4-yl-ethyl)-urea; cis-1-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrirnidin-7-yl]-cyclobutylrnethyl}-3-{2- morpholin-4-yl-ethyl)-urea; trans-1-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylrnethyl}-3- (2-dimethylamino-ethyl)"Urea; cis-1-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-3-(2- dimethylamino-ethy l)-urea; trans-1-{3-[4-amirio-5-(3-ben2yloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyciobutylmethyl}-3- (3-morpholin-4-yl-propyl)-urea; cis-1-{3-[4-aniino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylnriethyl}-3-(3- morpholin-4-yl-propyl)-urea; trans-1-{3-[4-amino-5-(3-ben2yloxy-phenyl)-pyrrolo[2.3-d]pynnr»idin-7-yl]-cyclobutylnieth^ (3-dimethylamino-propyl)-urea; cis-1-{3-[4-arnino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl}-3-( dimethylamino-propyl)-urea; trans-{3-[4-arnino-5-(3-benzyIoxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}- urea; cis-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrro!o[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl_-urea trans-N-{3-[4-amino-5-(3-ben2yloxy-phenyl)-pyrrolo[2,3-d]pyrirnidin-7-yl]-cyclobutylmethyl}- acetamide; cis-N-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7--yl]-cyciobutylmethyl}- acetamide; trans-N-{3-{4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl}- isobutyramide; cis-N-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}" isobutyramide; trans-N-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}- 2,2-dimethyl-propionamide; cis-N-{3-[4-amino-5-(3-benzy!oxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-2,2- dimethyl-propionamide; trans-N-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cycIobutylmethyl}-2- piperidin-1 -yl-acetamide; ds-N-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-2- piperidin-1 -yl-acetamide; trans-N-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl}-2- morpholin-4-yI-acetamide; cis-N-{3-[4-amino-5-(3-ben2yloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl}-2- morpholin-4-yl-acetamide; trans-N-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl}-2- (4-methyl-piperazin-1-yl)-acetamide; cis-N-{3-[4-amino-5-(3-ben2yloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl}-2-(4- methyl-pipera2in-1-yl)-acetamide; trans-5-(3-benzyIoxy-phenyl)-7-(3-morpholin-4-ylmethyl-cydobutyl)-7H-pyrrolo[2,3- d]pyrimidin-4-ylamine; trans-5-(3-benzyloxy-phenyl)-7-(3-piperidin-1-ylmethyl-cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin- 4-ylamine; trans-5-(3-benzyloxy-phenyl)-7-(3-pyrrolidin-1-ylmethyl-cyclobutyl)-7H-pyrrolo[2,3- d]pyrimidin-4-ylamine; trans-5-(3-benzyloxy-phenyl)-7-[3-(4-methyl-piperazin-1-ylmethyl)-cyclobutyl]-7H-pyrrolo[2,3- d]pyrimidin-4-ylamine; trans-7-[3-(adamantan-1-ylaminomethyl)-cyclobutyl]-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2,3 d]pyrimidin-4-ylamine; trans-1-{3-[4-amino-5-(3-ben2yloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-piperidin-4-ol; trans-7-(3-azepan-1-ylmethyl-Cyclobutyl)-5-(3-benzyloxy-phenyl)-7H-pyrrolo[2,3-d]pyrim 4-ylamine; trans-5-(3-benzyloxy-phenyl)-7-[3-(2,5-dimethyl-pyrrolidin-1-ylmethyl)-cyclobutyl]-7H pyrrolo[2.3-d]pyrimidin-4-ylamine; trans-7-(3-azetidin-1-ylmethyl-cyclobutyl)-5-(3-benzyloxy-pheny!)-7H-pyrrolo[2,3-d]pyrim 4-ylamine; trans-H3-[4-amino-5-(3-ben2yloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyd^ piperidine-3-carboxylic acid amide; trans-5-(3-ben2yloxy-phenyl)-7-[3-(4-pyridin-2-yUpipera2in-1-ylmethyl)-cyclobutyl]-7H- pyrrolo[2.3-d]pyrimidin-4-ylamine; trans-5-(3-benzyloxy-phenyl)-7-(3-lhiomorpholin-4-ylmethyl-cyclobutyl)-7H-pyrrolo[2,3- d]pyrimidin-4-ylamine; trans-5-(3-ben2yloxy-phenyl)-7-[3-(2,6-dimethyI-morpholin-4-ylmethyl)-cyclobutyl]-7H- pyrrolo[2.3-d]pyrimidin-4-ylamine; trans-(S)-1-{3-[4-amino-5-(3-ben2yloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]- cyclobutylmethyl}-pyrrolidine-2-carboxylic acid amide; cis-7-(3-azepan'1-ylmethyl-cyclobutyl)'5-(3-ben2yloxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4- ylamine; cis-1-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrro(o[2.3-d]pyrimidin-7-yl]-cyclobuty(methyl}- piperidin-4-ol; cis-4-{3-[4-am)no-5-(3-ben2yloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutyImethyl}- piperazine-1-carboxylic acid ethyl ester; cis-5-(3-benzyloxy-phenyl)-7-[3-(4-phenyl-piperazin-1-ylmethyl)-Cyclobutyl]-7H-pyrroloI2,3- d]pyrimidin-4-ylamine; cis-5-(3-benzyloxy-phenyl)-7-[3-(4-methyl-piperazin-1-ylmethyl)-CycIobutyl]-7H-pyrrolo[2,3- d]pyrimidin-4-ylamine; cis-5-(3-benzy{oxy-phenyl)-7-(3-thiomorpholin-4-ylmethyl-cyclobutyl)-7H-pyrrolo[2,3- d]pyrimidin-4-ylamine; cis-5-(3-benzyloxy-phenyl)-7-[3-(2.6-dimethyl-morpholin-4-yImethyl)-cycIobutyl]-7H- pyrrolo[2,3-d]pyrimidin-4-ylamine; cis-(R)-1-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutyl)-methyl}-pyrrolidine-2-carboxylic acid amide; cis-1-{3-[4'amino-5-(3-benzyioxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl}-piperidine-3-carboxylic acid amide; trans-N-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-2-ethoxy-acetamide; trans-N-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-Cyclobutylmethyl}^^ (2-methoxy-ethoxy)-acetamide; trans-H3-[4-amino-5-(3-ben2yloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-3-methyl-urea; cis-1-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cydobutylmethyl}-3- methyl-urea; trans-pyrrolidine-1-carboxylic acid {3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3- d]pyrimidin-7-yl]-cyclobutylmethyl}-amide; trans-piperidine-1-carboxylic acid{3-[4-aminO'5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin- 7-yl]-cyclobutylmethyl}-amide; trans-morpholine-4-carboxylicacid {3-[4-amino-5-(3-ben2yloxy-phenyl)-pyrrolo[2,3- d]pyrimidin-7-yl]-cyclobutylmethyl}-amide; trans-3-(3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl}- 1.1-dimethyl-urea; trans-4-methyl-piperazine-1 -carboxylic acid {3-[4-amino-5-(3-ben2yloxy-phenyl)-pyrrolo[2.3- d]pyrimidin-7-yl]-cyclobutylmethyl}-amide; trans-3-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl}- 1,1-diethyl-urea; trans-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutylmethyl}- carbamic acid 2-diethylamino-ethyl ester; trans-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}- carbamic acid 2-morpholin-4-yl-ethyl ester, trans-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}- carbamicacid 2-(4-methyl-pipera2in-1-yl)-ethyl ester; trans-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}- carbamic acid 2-dimethylamino-ethyl ester; trans-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}- carbamic acid ethyl ester; trans-4-{3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutyl piperazine-1-carboxylic acid ethyl ester; cis-5-(3-benzyloxy-phenyl)-7-(3-pyrrolidin-1-ylmethyl-cyclobutyl)-7H-pyrrolo[2.3-d]pyrimidi 4-ylamine; cis-7-(3-azetidin-1-ylmethyl-cyclobutyl)-5-(3-ben2yloxy-phenyl)-7H-pyrrolo[2,3-d]pyrim ylamine; and pharmaceutically acceptable salts thereof. 11. A compound of formula I according to claim 1, selected from the group consisting of trans-3-[4-Amino-5-(3-benzyloxy-phenyl)-6-bromo-pyrrolo[2,3-d]pyrimldin-7-yl]- cyclobutanecarboxylic acid methylester; trans-3-[4-Amino-5-(3-benzyloxy-phenyl)-6-methyl-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutanecarboxylic acid methyl ester; trans-{3-[4-Amino-5-(3-benzyloxy-phenyl)-6-methyl-pyrroIo[2.3-d]pyrimidin-7-yl]-cyclobutyl}-methanol; cis-3-[4-Amino-5-(3-benzyloxy-phenyl)-6-bromo-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutanecarboxylic acid methyl ester; cis-3-[4-Amino-5-(3-benzyloxy-phenyl)-6-methyl-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutanecarboxylic acid methyl ester; cis-{3-[4-Amino-5-(3-benzyloxy-phenyl)-6-methyl-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutyl}-methanol; cis-3-[4-Amino-5-(3-benzyloxy-phenyl)-6-ethyl-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutanecarboxylic acid methyl ester; trans-3-[4-Amino-5-(3-benzyloxy-phenyl)-6-ethyl-pyrrolo[2.3-d]pyrimidin-7-yl]- cyclobutanecarboxylic acid methyl ester; cis-{3-[4-Amino-5-(3-benzyloxy-phenyl)-6-ethyl-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutyl}- methanol; trans-{3-[4-Amino-5-(3-benzyloxy-phenyl)-6-ethyl-pyrrolo[2.3-d]pyrimidin-7-yl]-cyclobutyl}- methanol; and pharmaceutically acceptable salts thereof. 12. A compound of formula I according to claim 3, selected from the group consisting of trans-5-(3-Benzyloxy-phenyl)-6-methyl-7-(3-pyrrolidin-1-ylmethyl-cyclobutyl)-7H-pyrrolo[2,3- d]pyrimidin-4-ylamine; trans-5-(3-Benzyloxy-phenyl)-6-methyl-7-[3-(4-methyl-piperazin-1-ylmethyl)-cyclobutyl-pyrrolo[2,3-d]pyrimidin-4-ylamine; trans-1-{3-[4-Amino-5-(3-benzyloxy-phenyl)-6-methyl-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-piperidin-4-ol; trans-7-{3-A2etidin-1-ylmelhyl-cyclobutyl)-5-(3-benzyloxy-phenyl)-6-methyl-7H-pyrrolo[2.3- d]pyrimidin-4-ylamine; trans-5-(3-Ben2yloxy-phenyl)-6-methyl-7-{3-[{tetrahydro-pyran-4-ylamino)-rnethyl]- cyclobutyl}-7H-pyrrolo[2.3-d]pyrimidin-4-ylamine; trans-((R)-1-{3-[4-Amino-5-(3-benzyloxy-phenyl)-6-methyl-pyrrolo[2,3-d]pyrim cyclobutylmethyl}-pyrrolidin-2-yl)-methanol; cis-5-(3-Benzyloxy-phenyl)-6-methyl-7-(3-pyrrolidin-1-ylmethyl-cyclobutyl)-7H]-7H- d]pyrimidin-4-ylamine; cis-5-(3-Benzyloxy-phenyl)-6-methyl-7-[3-(4-methyl-pipera2in-1-ylmethyl)-cyclobutyl]-7H pyrrolo[2,3-d]pyrimidin-4-ylamine; cis-7-(3-A2etidin-1-ylmethyl-cyclobutyl)-5-(3-ben2yloxy-phenyl)-6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-ylamine; cis-1-{3-[4-Amino-5-(3-benzyloxy-phenyl)-6-methyl-pyrrolo[2,3-d]pyrimJdin-7-yl]- cycIobutylmethyl}-piperfdin-4-ol; cis-((R)-H3-[4-Amino-5-(3-benzyloxy-phenyl)-6-methyl-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutylmethyl}-pyrrolidin-2-yl)-methanol; cis-5-(3-Benzyloxy-phenyl)-6-ethyl-7-(3-pyrrolidin-1-ylmethyl-cyclobutyl)-7H-pyrroto d]pyrimidin-4-ylamine; cis-5-(3-Benzyloxy-phenyl)-6-ethyl-7-[3-(4-methyl-piperazin-1-ylmethyl)-cyclobutyl]-7H pyrrolo[2,3-d]pyrimidin-4-ylamine; cis-7-(3-Azetidin-1-yimethyl-cyclobutyl)-6-ethyl-5-{3-[(Z)-2-eth-(E)-ylidene-hexa-3.5- dienyloxy]-phenyl}-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine; cis-1-{3-[4-Amino-5-(3-benzyIoxy-phenyl)-6-ethyl-pyrrolo[2,3-d]pyrimidin-7-yl]- cyclobutylmethyl}-piperidin-4-ol; cis-((R)-1-{3-[4-Amino-5-(3-benzyloxy-phenyl)-6-ethyl-pyrrolo[2,3-d]pyrimidin-7-yl cyclobutylmethyl}-pyrrolidin-2-yl)-methanol; cis-5-(3-Benzyloxy-phenyl)-6-ethyl-7-{3-[(tetrahydro-pyran-4-ylamino)-methyl]-cyclobutyl}-7H pyrrolo[2,3-d]pyrimidin-4-ylamine; and phamnaceutically acceptable salts thereof. 13. A compound of formula I. or a pharmaceutically acceptable salt thereof, according to any one of claims 1 to 12 for use in a method for the treatment of the human or animal body. 14. A pharmaceutical composition comprising a compound of formula I or a pharmaceutically acceptable salt thereof according to any one of claims 1 to 12, together with at least one pharmaceutically acceptable carrier. 15. Use of a compound of formula I according to any one of claims 1 to 12, or a pharmaceutically acceptable salt thereof, for the preparation of a pharmaceutical composition for the treatment of a disease which responds to an inhibition of the IGF-IR-dependent cell proliferation. 16. Use of a compound of formula I according to any one of claims 1 to 12, or a pharmaceutically acceptable salt thereof, for the preparation of a pharmaceutical composition for the treatment of a disease which responds to an inhibition of the IGF-IR tyrosine kinase. 17. A process for the preparation of a compound of formula I according to claim 1 or of a salt of such a compound, characterized in that a) in order to prepare a compound of formula I, in which R2 is lower alkyl substituted by amino, a compound of formula II wherein n, R1, R3, R4 and X have the meanings as defined for a compound of formula I according to claim 1, is reacted with hydrazine; b) in order to prepare a compound of formula I, in which R2 is a radical R5-(C=Y)-Z- wherein R5 is unsubstituted, mono- or disubstituted amino, Y is oxygen and Z is not present or lower alkyl, a compound of formula III in which R10 is a radical HO-(C=O)-Z- wherein Z is not present or lower alkyl, and n, Ri. R3, R4 and X have the meanings as defined for a compound of formula ! according to claim 1, is reacted with a compound of the formula R5-H wherein R5 is unsubstituted, mono- or disubstituted amino; c) in order to prepare a compound of formula I, in which R2 is lower alkyl substituted by mono- or disubstituted amino, a compound of formula I, in which R2 is a radical R5-(C=Y)-Z-wherein R5 is mono- or disubstituted amino, Y is oxygen and Z is not present or lower alkyl, is reacted with lithium aluminium hydride; d) in order to prepare a compound of formula I, in which R2 is lower alkyl substituted by mono- or disubstituted amino or by a heterocyclic radical containing at least one nitrogen ring atom whereby the binding of the heterocyclic radical to lower alkyl occurs via a nitrogen ring atom, a compound of formula IV in which R11 is lower alkyl substituted by 4-methylphenylsulfonyloxy and n. R1, R3. R4 and X have the nneanings as defined for a compound of formula I according to claim 1, is reacted with a compound of the formula R17-H in which R17 is mono- or disubstituted amino or a heterocyclic radical containing at least one nitrogen ring atom wherein the heterocyclic radical is attached to the hydrogen atom of R17-H via a nitrogen ring atom; e) in order to prepare a compound of formula I. in which R2 is a radical R6-sulfonylamino-lower alkyl wherein R6 has the meanings as defined for a compound of formula I according to claim 1, a compound of formula I according to claim 1, in which R2 is amino-lower alkyl, is reacted with R6-sulfonyl halide; f) in order to prepare a compound of formula I, in which R2 is a radical R5-(C=Y)-Z- wherein R5 is free or etherified hydroxy. Y is oxygen and Z is amino-lower alkyl, a compound of formula I according to claim 1, in which R2 is amino-lower alkyl, is reacted with a compound of the formula R5-(C=0)-Halogen wherein R5 is free or etherified hydroxy; g) in order to prepare a compound of formula I, in which R2 is a radical R5-(C=Y)-Z- wherein R5 is unsubstituted or monosubstltuted amino. Y is oxygen or sulfur and Z is amino-lower alkyl, a compound of formula I according to claim 1, in which R2 is amino-lower alkyl. is reacted with a compound of the fomiula Ri2-N=C=Y wherein Y is oxygen or sulfur, the radical R12-NH- corresponding to unsubstituted or monosubstituted amino R5; h) in order to prepare a compound of formula I, in which R2 is a radical R5-(C=Y)-Z- wherein R5 is unsubstituted. mono- or disubstituted amino or a heterocyclic radical containing at least one nitrogen ring atom whereby the binding of the heterocyclic radical occurs via a nitrogen ring atom, Y is oxygen and Z is amino-lower alkyl. a compound of fomiula I according to claim 1, in which R2 is a radical R5-(C=Y)-Z- wherein R5 is imidazol-1-yl, Y is oxygen and Z is amino-lower alkyl. is reacted with a compound of the formula R5-H, in which R5 is unsubsti-tuted, mono- or disubstituted amino, or a heterocyclic radical which contains at least one nitrogen ring atom; i) in order to prepare a compound of formula I, in which R2 is a radical R5-(C=Y)-Z- wherein R5 is unsubstituted or substituted lower alkyl, Y is oxygen and Z is amino-lower alkyl, a compound of formula I according to claim 1. in which R2 is amino-lower alkyl. is reacted with a compound of the formula R5-(C=0)-Halogen wherein R5 is unsubstituted or substituted lower alkyl; j) in order to prepare a compound of formula I, in which R2 is a radical R5-(C=Y)-Z- wherein R5 is lower alkyl substituted by a heterocyclic radical containing at least one nitrogen ring atom whereby the binding of the heterocyclic radical to lower alkyl occurs via a nitrogen ring atom. Y is oxygen and Z is amino-lower alkyl, a compound of formula V in which n, R1. R3, R4 and X have the meanings as defined for a compound of formula I according to claim 1, is reacted with a compound of the formula R18-H in which R18 is a heterocyclic radical containing at least one nitrogen ring atom wherein the heterocyclic radical is attached to the hydrogen atom of R18-H via a nitrogen ring atom; k) in order to prepare a compound of formula I, in which R2 is a radical R5-(C=Y)-Z- wherein R5 is lower alkylamino wherein the lower alkyl moiety is substituted by unsubstituted, mono- or disubstituted amino or by a heterocyclic radical containing at least one nitrogen ring atom whereby the binding of the heterocyclic radical to the lower alkyl moiety occurs via a nitrogen ring atom. Y is oxygen or sulfur and Z is amino-lower alkyl, a compound of formula VI in which Y is oxygen or sulfur and n, R1, R3. R4 and X have the meanings as defined for a compound of formula I according to claim 1, is reacted with a compound of the formula R13-H. in which R13 is unsubstituted, mono- or disubstituted amino or a heterocyclic radical containing at least one nitrogen ring atom wherein the heterocyclic radical is attached to the hydrogen atom of R13-H via a nitrogen ring atom; I) in order to prepare a compound of formula I, in which R2 is a radical R5-(C=Y)-Z- wherein R5 is lower alkoxy substituted by unsubstituted, mono- or disubstituted amino or by a heterocyclic radical containing at least one nitrogen ring atom whereby the binding of the heterocyclic radical to the lower alkyl moiety of lower alkoxy occurs via a nitrogen ring atom, Y is oxygen and Z is amino-lower alkyl, a compound of formula VII in which n, R1, R3. R4 and X have the meanings as defined for a compound of formula I according to claim 1, is reacted with a compound of the formula R14-H, in which R14 is unsubsti-tuted, mono- or disubstituted amino or a heterocyclic radical containing at least one nitrogen ring atom wherein the heterocyclic radical is attached to the hydrogen atom of R14-H via a nitrogen ring atom; m) in order to prepare a compound of formula I, in which R1 is halogen, a compound of formula I according to claim 1, in which R1 is hydrogen, is reacted with N-halosuccinimide; n) in order to prepare a compound of formula I. in which R1 is lower alkyl, a compound of formula I according to claim 1, in which R1 is halogen, is reacted with tetra(lower alkyl) tin; o) in order to prepare a compound of formula I, a compound of formula IX in which n, R1, R3, R4 and X have the meanings as defined for a compound of formula I according to claim 1, Is reacted with a compound of formula X in which R2 has the meanings as defined for a compound of formula I according to claim 1; p) in order to prepare a compound of formula I, in which R2 is lower alkyl substituted by hydroxy wherein hydroxy is attached to a primary carbon atom, a compound of formula I according to claim 1, in which R2 is a radical R5-(C-Y)-Z- wherein R5 is etherified hydroxy, Y is oxygen and Z is not present or C1-C6alkyI, is reacted with lithium aluminiumhydride; or q) in order to prepare a compound of formula I, in which R2 is lower alkyl substituted by hydroxy wherein hydroxy is attached to a secondary or tertiary carbon atom, a compound of formula XI in which R15 is a radical Ri6-(C=O)-Q- wherein R16 is hydrogen or C1-C5alkyI and Q is not present or C1-C5alkyI, is reacted with a Grignard reagent of the formula C1-C6alkyl-Mg-halide; whereby functional groups which are present in the starting compounds of processes a) to q) and are not intended to take part in the reaction, are present in protected form if necessary, and protecting groups that are present are cleaved, whereby said starting compounds may also exist in the form of salts provided that a salt-forming group is present and a reaction in salt form is possible. and, if so desired, a compound of formula I thus obtained is converted into another compound of formula I, a free compound of formula I is converted into a salt, an obtained salt of a compound of formula I is converted into the free compound or another salt, and/or a mixture of isomeric compounds of formula I is separated into the individual isomers. 18. A pharmaceutical composition substantially as herein described with reference to the accompanying drawings. 19. A process for the preparation of a compound substantially as herein described with reference to the accompanying drawings. Dated this 7 day of November 2003

Documents:

1760-chenp-2003 abstract-granded.pdf

1760-chenp-2003 claims-granded.pdf

1760-chenp-2003 description (complete)-granded.pdf

1760-chenp-2003-abstract.pdf

1760-chenp-2003-claims.pdf

1760-chenp-2003-correspondnece-others.pdf

1760-chenp-2003-correspondnece-po.pdf

1760-chenp-2003-description(complete).pdf

1760-chenp-2003-form 1.pdf

1760-chenp-2003-form 3.pdf

1760-chenp-2003-form 5.pdf

1760-chenp-2003-other documents.pdf

1760-chenp-2003-pct.pdf