Title of Invention	"A METHOD FOR ALTERING THE CONDUCTIVITY OF AN ORGANIC CIRCUIT ELEMENT"
Abstract	A method for altering the conductivity of an organic circuit element (100), wherein the organic circuit element comprises: a) a plurality of members (102), each of which comprises an oligonucleotide duplex, said plurality of members comprising: i) at least one donor member (104) for receiving conduction electrons from an electron donor (200); ii) at least one acceptor member (106) for communicating with an electron acceptor (220) to provide a region of attraction for said conduction electrons; and iii) at least one regulator member (108) intersecting with at least one of said plurality of members (102) to define at least one electric field regulation junction (112), for cooperating with an electric field regulator (114) to regulate an electric field at the junction (11 2); characterized in that the conductivity of the organic circuit element (100) is altered by reversibly chemically modifying the electron donor (200) or the electron acceptor (220) under conditions that preserve the conductivity of the organic circuit element (100).

Title of Invention

"A METHOD FOR ALTERING THE CONDUCTIVITY OF AN ORGANIC CIRCUIT ELEMENT"

Abstract

A method for altering the conductivity of an organic circuit element (100), wherein the organic circuit element comprises: a) a plurality of members (102), each of which comprises an oligonucleotide duplex, said plurality of members comprising: i) at least one donor member (104) for receiving conduction electrons from an electron donor (200); ii) at least one acceptor member (106) for communicating with an electron acceptor (220) to provide a region of attraction for said conduction electrons; and iii) at least one regulator member (108) intersecting with at least one of said plurality of members (102) to define at least one electric field regulation junction (112), for cooperating with an electric field regulator (114) to regulate an electric field at the junction (11 2); characterized in that the conductivity of the organic circuit element (100) is altered by reversibly chemically modifying the electron donor (200) or the electron acceptor (220) under conditions that preserve the conductivity of the organic circuit element (100).

Full Text	We Claim: 1. A method for altering the conductivity of an organic circuit element (100), wherein the organic circuit element comprises: a) a plurality of members (102), each of which comprises an oligonucleotide duplex, said plurality of members comprising: i) at least one donor member (104) for receiving conduction electrons from an electron donor (200); ii) at least one acceptor member (106) for communicating with an electron acceptor (220) to provide a region of attraction for said conduction electrons; and iii) at least one regulator member (108) intersecting with at least one of said plurality of members (102) to define at least one electric field regulation junction (112), for cooperating with an electric field regulator (114) to regulate an electric field at the junction (112); characterized in that the conductivity of the organic circuit element (100) is altered by reversibly chemically modifying the electron donor (200) or the electron acceptor (220) under conditions that preserve the conductivity of the organic circuit element (100). 2. The method as claimed in claim 1 wherein at least one of said members (102) comprises a conductive metal-containing oligonucleotide duplex. 3. The method as claimed in claim 1 or 2 wherein said electron donor (200) is in electrical communication with said donor member (104). 4. The method as claimed in claim 3 wherein said electron acceptor (220) is in electrical communication with said acceptor member (106). 5. The method as claimed in claim 4 wherein said electric field regulator (114) is in electrical communication with said regulator member (108). 6. The method of any one of claims 1-5 wherein said donor member (104), said acceptor member (106) and said regulator member (108) intersect to define said electric field regulation junction (112). 7. The method of any one of claims 1-5 wherein said regulator member (108) intersects with one of said donor member (104) and said acceptor member (106) to define said electric field regulation junction (112). 8. The method of any one of claims 1-7 wherein said conductive metal-containing oligonucleotide duplex comprises a first nucleic acid strand (320) and a second nucleic acid strand (340), said first and said second nucleic acid strands comprising respective pluralities of nitrogen-containing aromatic bases (350, 360) covalently linked by a backbone (380), said nitrogen-containing aromatic bases of said first nucleic acid strand being joined by hydrogen bonding to said nitrogen-containing aromatic bases of said second nucleic acid strand, said nitrogen-containing aromatic bases on said first and said second nucleic acid strands forming hydrogen-bonded base pairs (400) in stacked arrangement along a length of said conductive metal-containing oligonucleotide duplex (300), said hydrogen-bonded base pairs comprising an interchelated metal cation (420) coordinated to a nitrogen atom in one of said nitrogen-containing aromatic bases (350, 360). 9. The method as claimed in claim 8 wherein said interchelated metal cation comprises an interchelated divalent metal cation. 10.The method as claimed in claim 9 wherein said divalent metal cation is selected from the group consisting of zinc, cobalt and nickel. 11. The method as claimed in claim 8, 9, or 10 wherein said first and said second nucleic acid strands comprise deoxyribonucleic acid and said nitrogen-containing aromatic bases are selected from the group consisting of adenine, thymine, guanine and cytosine. 12.The method of any one of claims 1 to 11 wherein said electron donor comprises an electrode operable to donate an electron to said donor member. 13.The method of any one of claims 1 to 12 wherein said electron acceptor comprises an electrode operable to accept an electron from said acceptor member. 14. The method of any one of claims 1 to 11 wherein said electron donor comprises an electron donor molecule capable of donating an electron to said donor member. 15.The method as claimed in claim 14 wherein said electron donor molecule comprises a fluorescent molecule. 16.The method as claimed in claim 14 wherein said electron donor molecule comprises fluorescein. 17.The method of any one of claims 1 to 16 wherein said electron acceptor comprises an electron acceptor molecule capable of accepting an electron from said acceptor member. 18. The method as claimed in claim 17 wherein said electron acceptor molecule comprises a fluorescent molecule. 19.The method as claimed in claim 17 wherein said electron acceptor molecule comprises rhodamine. 20.The method as claimed in claim 17, wherein said electron acceptor molecule comprises anthraquinone. 21. The method as claimed in claim 20, wherein the conductivity of the organic circuit element is altered by reversibly chemically reducing the anthraquinone to dihydroanthraquinone. 22.The method of any one of claims 1 to 21 wherein said electric field regulator comprises a regulator chromophore. 23. The method of any one of claims 1 to 21 wherein said electric field regulator comprises a rhodamine. 24. The method of any one of claims 1 to 21 wherein said electric field regulator comprises an electrode. 25.The method of any one of claims 1 to 24 wherein said electric field regulator comprises a plurality of states, each state of said plurality of states being selectable to produce a respective electrostatic potential at said electric field regulation junction. 26.The method as claimed in claim 25 wherein said states are selectable in response to an applied external potential. 27.The method of any one of claims 1 to 26 wherein the organic circuit element is provided in a conductive medium that supplies conduction electrons to said electron donor and receives conduction electrons from said electron acceptor. 28.The method as claimed in claim 27 wherein said conductive medium is operable to donate electrons to said electron donor, and is operable to accept electrons from said electron acceptor to provide a closed circuitway for electrons to flow from said electron donor, through said donor member, through said electric field regulation junction, through said acceptor member, through said electron acceptor, and back to said electron donor. 29. The method as claimed in claim 27 or 28 wherein said conductive medium comprises an aqueous solution. 30.A method for altering the conductivity of an organic circuit element substantially as herein described with reference to the accompanying drawings and as illustrated in the foregoing examples.

Full Text

We Claim:
1. A method for altering the conductivity of an organic circuit element (100),
wherein the organic circuit element comprises:
a) a plurality of members (102), each of which comprises an oligonucleotide duplex, said plurality of members comprising: i) at least one donor member (104) for receiving conduction electrons
from an electron donor (200); ii) at least one acceptor member (106) for communicating with an electron acceptor (220) to provide a region of attraction for said conduction electrons; and iii) at least one regulator member (108) intersecting with at least one of said plurality of members (102) to define at least one electric field regulation junction (112), for cooperating with an electric field regulator (114) to regulate an electric field at the junction (112); characterized in that the conductivity of the organic circuit element (100) is altered by reversibly chemically modifying the electron donor (200) or the electron acceptor (220) under conditions that preserve the conductivity of the organic circuit element (100).
2. The method as claimed in claim 1 wherein at least one of said members (102) comprises a conductive metal-containing oligonucleotide duplex.
3. The method as claimed in claim 1 or 2 wherein said electron donor (200) is in electrical communication with said donor member (104).
4. The method as claimed in claim 3 wherein said electron acceptor (220) is in electrical communication with said acceptor member (106).
5. The method as claimed in claim 4 wherein said electric field regulator (114) is in electrical communication with said regulator member (108).
6. The method of any one of claims 1-5 wherein said donor member (104), said acceptor member (106) and said regulator member (108) intersect to define said electric field regulation junction (112).

7. The method of any one of claims 1-5 wherein said regulator member (108) intersects with one of said donor member (104) and said acceptor member (106) to define said electric field regulation junction (112).
8. The method of any one of claims 1-7 wherein said conductive metal-containing oligonucleotide duplex comprises a first nucleic acid strand (320) and a second nucleic acid strand (340), said first and said second nucleic acid strands comprising respective pluralities of nitrogen-containing aromatic bases (350, 360) covalently linked by a backbone (380), said nitrogen-containing aromatic bases of said first nucleic acid strand being joined by hydrogen bonding to said nitrogen-containing aromatic bases of said second nucleic acid strand, said nitrogen-containing aromatic bases on said first and said second nucleic acid strands forming hydrogen-bonded base pairs (400) in stacked arrangement along a length of said conductive metal-containing oligonucleotide duplex (300), said hydrogen-bonded base pairs comprising an interchelated metal cation (420) coordinated to a nitrogen atom in one of said nitrogen-containing aromatic bases (350, 360).
9. The method as claimed in claim 8 wherein said interchelated metal cation comprises an interchelated divalent metal cation.
10.The method as claimed in claim 9 wherein said divalent metal cation is selected from the group consisting of zinc, cobalt and nickel.
11. The method as claimed in claim 8, 9, or 10 wherein said first and said second nucleic acid strands comprise deoxyribonucleic acid and said nitrogen-containing aromatic bases are selected from the group consisting of adenine, thymine, guanine and cytosine.
12.The method of any one of claims 1 to 11 wherein said electron donor comprises an electrode operable to donate an electron to said donor member.
13.The method of any one of claims 1 to 12 wherein said electron acceptor comprises an electrode operable to accept an electron from said acceptor member.
14. The method of any one of claims 1 to 11 wherein said electron donor comprises an electron donor molecule capable of donating an electron to said donor member.

15.The method as claimed in claim 14 wherein said electron donor molecule
comprises a fluorescent molecule. 16.The method as claimed in claim 14 wherein said electron donor molecule
comprises fluorescein. 17.The method of any one of claims 1 to 16 wherein said electron acceptor
comprises an electron acceptor molecule capable of accepting an electron
from said acceptor member. 18. The method as claimed in claim 17 wherein said electron acceptor molecule
comprises a fluorescent molecule. 19.The method as claimed in claim 17 wherein said electron acceptor molecule
comprises rhodamine. 20.The method as claimed in claim 17, wherein said electron acceptor molecule
comprises anthraquinone. 21. The method as claimed in claim 20, wherein the conductivity of the organic
circuit element is altered by reversibly chemically reducing the anthraquinone
to dihydroanthraquinone. 22.The method of any one of claims 1 to 21 wherein said electric field regulator
comprises a regulator chromophore.
23. The method of any one of claims 1 to 21 wherein said electric field regulator comprises a rhodamine.
24. The method of any one of claims 1 to 21 wherein said electric field regulator comprises an electrode.
25.The method of any one of claims 1 to 24 wherein said electric field regulator comprises a plurality of states, each state of said plurality of states being selectable to produce a respective electrostatic potential at said electric field regulation junction.
26.The method as claimed in claim 25 wherein said states are selectable in response to an applied external potential.
27.The method of any one of claims 1 to 26 wherein the organic circuit element is provided in a conductive medium that supplies conduction electrons to said electron donor and receives conduction electrons from said electron acceptor.

28.The method as claimed in claim 27 wherein said conductive medium is operable to donate electrons to said electron donor, and is operable to accept electrons from said electron acceptor to provide a closed circuitway for electrons to flow from said electron donor, through said donor member, through said electric field regulation junction, through said acceptor member, through said electron acceptor, and back to said electron donor.
29. The method as claimed in claim 27 or 28 wherein said conductive medium comprises an aqueous solution.
30.A method for altering the conductivity of an organic circuit element substantially as herein described with reference to the accompanying drawings and as illustrated in the foregoing examples.

Documents:

2753-DELNP-2005-Abstract-(25-11-2008).pdf

2753-DELNP-2005-Abstract-12-12-2008.pdf

2753-delnp-2005-abstract.tif

2753-DELNP-2005-Claims-(25-11-2008).pdf

2753-DELNP-2005-Claims-12-12-2008.pdf

2753-delnp-2005-claims.tif

2753-delnp-2005-correspondence-other.tif

2753-DELNP-2005-Correspondence-Others-(25-11-2008).pdf

2753-DELNP-2005-Description (Complete)-(25-11-2008).pdf

2753-delnp-2005-description complete.tif

2753-DELNP-2005-Drawings-(25-11-2008).pdf

2753-delnp-2005-drawings.tif

2753-DELNP-2005-Form-1-(25-11-2008).pdf

2753-delnp-2005-form-13-(25-11-2008).pdf

2753-DELNP-2005-Form-2-(25-11-2008).pdf

2753-DELNP-2005-Form-5-(25-11-2008).pdf

2753-delnp-2005-form-6-11-08-2006.pdf

2753-delnp-2005-form1.tif

2753-delnp-2005-form13.tif

2753-delnp-2005-form18.tif

2753-delnp-2005-form2.tif

2753-delnp-2005-form26.tif

2753-delnp-2005-form3.tif

2753-delnp-2005-form5.tif

2753-DELNP-2005-Petition-137-(25-11-2008).pdf

2753-DELNP-2005-Petition-138-(25-11-2008).pdf

2753.png

2953-DELNP-2005-Correspondence-Others-(11-12-2008).pdf

2953-DELNP-2005-Form-3-(11-12-2008).pdf

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Patent Number

226633

Indian Patent Application Number

2753/DELNP/2005

PG Journal Number

03/2009

Publication Date

16-Jan-2009

Grant Date

22-Dec-2008

Date of Filing

21-Jun-2005

Name of Patentee

UNIVERSITY OF SASKATCHEWAN

Applicant Address

RPO BOX 4000 UNIVERSITY, 110 GYMNASIUM PLACE, SASKATOON, SASKATCHEWAN S7N 4J8, CANADA.

Inventors:

#	Inventor's Name	Inventor's Address
1	KRAATZ HEINZ-BERNHARD	1111-7TH STREET EAST, SASKATOON, SASKATCHEWAN S7H 0Y9, CANADA
2	LEE JEREMY S.	UNIVERSITY OF SASKATCHEWAN TECHNOLOGIES INC., ROOM 304, KIRK HALL, THE UNITVERSITY OF SASKATCHEWAN, 117 SCIENCE PLACE, SASKATOON,, SASKATCHEWAN S7N 5C8, CANADA
3	WETTIG SHAWN D	1327 KONIHOWSKI ROAD, SASKATOON, SASKATCHEWAN S7S AL5, CANADA
4	SKINNER RYAN JOHN	1560 1ST STREET EAST, PRINCE ALBERT, SASKATCHEWAN S6V 0E7, CANADA

PCT International Classification Number

G06N3/00

PCT International Application Number

PCT/CA2003/001589

PCT International Filing date

2003-10-15

PCT Conventions:

#	PCT Application Number	Date of Convention	Priority Country
1	60/435,276	2002-12-23	U.S.A.