Title of Invention	"SULFONAMIDE COMPOUNDS"
Abstract	Sulfonamide compounds of general formula (la), wherein R1, R2, R3, R4, R5, R6, A and B are as herein defined.

Full Text

The present invention relates to sulfonamide compounds. The present invention refers to new sulfonamide derivatives, of general formula (la, lb, lc), (Formula Removed) optionally in form of one of their stereoisomers, preferably enantiomers or diastereomers, their racemate, or in form of a mixture of at least two of their stereoisomers, preferably enantiomers or diastereomers, in any mixing ratio, or their salts, preferably their corresponding, physiologically acceptable salts, or corresponding solvates; to the processes for their preparation, to their application as medicaments in human and/or veterinary therapeutics, and to the pharmaceutical compositions containing them. The new compounds of the present invention can be used in the pharmaceutical industry as intermediates and for preparing medicaments. The superfamily of serotonin receptors (5-HT) comprises 7 classes (5-HT1-5-HT7), which cover 14 human subclasses [D. Hoyer, et al., Neuropharmacology, 1997, 36, 419]. The 5-HT6 receptor has been the last serotonin receptor identified by molecular cloning in rats [F.J. Monsma, et al., Mol. Pharmacol., 1993, 43, 320; M. Ruat, et al., Biochem. Biophys. Res. Commun., 1993, 193, 268] as well as in humans [R. Kohen, et al., J. Neurochem., 1996, 66, 47]. The compounds with an affinity for the 5-HTe receptor are useful in treating different disorders of the Central Nervous System and of the Gastrointestinal system, as well as the irritable bowel syndrome. The compounds with an affinity for the 5-HT6 receptor are useful for treating anxiety, depression and cognitive memory disorders [M. Yoshioka, et al., Ann. NYAcad. Sci,, 1998, 861, 244; A. Bourson, et al., Br. J. Pharmacol., 1998, 125, 1562; D.C. Rogers, et al., Br. J. Pharmacol. Suppl., 1999, 127, 22P; A. Bourson, et al., J. Pharmacol. Exp. Ther., 1995, 274, 173; A.J. Sleight, et al., Behav. Brain Res., 1996, 73, 245; T.A. Branchek, et al., Annu. Rev. Pharmacol. Toxicol., 2000, 40, 319; C. Routiedge, et al., Br. J. Pharmacol., 2000, 130,1606]. It has been shown that the typical and atypical antipsychotics for treating schizophrenia have a high affinity for the 5-HTe receptors [B.L. Roth, et al., J. Pharmacol. Exp. Ther., 1994, 268,1403; C.E. Glatt, et al., Mol. Med., 1995,1, 398; F.J. Mosma, et a)., Mol. Pharmacol., 1993, 43, 320; T. Shinkai, et al, Am. J. Med. Genet., 1999, 88, 120]. The compounds with an affinity for the 5-HTe receptor are useful for treating infantile hyperkinesia (ADHD, attention deficit / hyperactivity disorder) [W.D. Hirst, et al., Br. J. Pharmacol., 2000, 130, 1597; C. Gerard, et al., Brain Research, 1997, 746, 207; M.R. Pranzatelli, Drugs of Today, 1997, 33, 379]. Patent application WO 01/32646 discloses sulfonamides derived from bicycles whereby each of the rings is 6-membered, aromatic or heteroaromatic rings with 5-HTe receptor antagonist activity. Patent application EP 0 733 628 discloses sulfonamides derived from indole with 5-HT1F receptor antagonist activity, useful for the treatment of migraines. Furthermore, it has been shown that the 5-HTe receptor plays a.role in the ingestion of food [Neuropharmacology, 41, 2001, 210-219]. Eating disorders, particularly obesity, are a serious and increasingly frequent threat for the health of humans of all ages, since these dieseases increase the risk of developing other serious and even mortal diseases, preferably diabetes and coronary artery diseases. Therefore, an object of the present invention was to provide new compounds, particularly suitable as active substances in medicaments, preferably in medicaments for 5-HTe receptor regulation, for the prophylaxis and/or treatment of a disorder or disease related to food intake, preferably for the regulation of appetite, for the maintenance, increase or reduction of body weight, for the prophylaxis and/or treatment of obesity, bulimia, anorexia, cachexia or type II diabetes (non insulin dependent diabetes mellitus), preferably type II diabetes caused by obesity, for the prophylaxis and/or treatment of gastrointestinal tract disorders, preferably irritable bowel syndrome, for cognitive enhancement, for the prophylaxis and/or treatment of disorders of the central nervous system, anxiety, panic disorders, depression, preferably bipolar disorders, cognitive memory disorders, senile dementia processes, neurodegenerative disorders, preferably Alzheimer's disease, Parkinson's disease, Huntington's disease and/or Multiple Sclerosis, schizophrenia, psychosis or infantile hyperkinesia (ADHD, attention deficit / hyperactivity disorder), and other disorders mediated by the 5-HTe serotonin receptor in humans and/or in animals, preferably in mammals, more preferably in humans. It has been found that the 1-sulfonylindole derivatives of general formulas (la, Ib, Ic) described below show an affinity for the 5-HTe receptor. These compounds are therefore suitable for preparing a medicament for the prophylaxis and/or treatment of a disorder or disease related to food intake, preferably for the regulation of appetite, for the maintenance, increase or reduction of body weight, for the prophylaxis and/or treatment of obesity, bulimia, anorexia, cachexia or type II diabetes (non insulin dependent diabetes mellitus), preferably type II diabetes caused by obesity, for the prophylaxis and/or treatment of gastrointestinal tract disorders, preferably irritable bowel syndrome, for cognitive enhancement, for the prophylaxis and/or treatment of disorders of the central nervous system, anxiety, panic disorders, depression, preferably bipolar disorders, cognitive memory disorders, senile dementia processes, neurodegenerative disorders, preferably Alzheimer's disease, Parkinson's disease, Huntington's disease and/or Multiple Sclerosis, schizophrenia, psychosis or infantile hyperkinesia (ADHD, attention deficit/ hyperactivity disorder), and other disorders mediated by the 5-HTe serotonin receptor in humans and/or in animals, preferably in mammals, more preferably in humans. These compounds are also suitable for the preparation of a medicament for cognitive enhancement. Thus, one aspect of the present invention are compounds of general formula (la), R1 represents a -NR7R8 radical or a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as a ring member containing cycloaliphatic radical, which may be condensed with a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as a ring member containing mono- or bicyclic cycloaliphatic ring system, R2, R3, R4, R5 and R6, identical or different, each represent hydrogen, halogen, cyano, nitro, a saturated or unsaturated, linear or branched aliphatic radical, a linear or branched alkoxy radical, a linear or branched alkylthio radical, hydroxy, trifluoromethyl, a saturated or unsaturated cycloaliphatic radical, an alkylcarbonyl radical, a phenylcarbonyl or a -NR9R10 group, R7 and R8, identical or different, each represent hydrogen or a saturated or unsaturated, optionally at least mono-substituted linear or branched aliphatic radical, with the proviso that R8 and R9 are not hydrogen at the same time, and if one of them, R8 or R9, is a saturated or unsaturated, linear or branched, optionally at least mono-substituted CrC4 aliphatic radical, the other one is a saturated or unsaturated, linear or branched, optionally at least mono-substituted aliphatic radical with at least five carbon atoms, or R7 and R8, together with the bridging nitrogen atom form a saturated or unsaturated, optionally at least mono-substituted, optionally at least one further heteroatom as a ring member containing heterocyclic ring which may be condensed with a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as a ring member containing mono- or bicyclic cycloaliphatic ring system, R9 and R10, identical or different, each represent hydrogen or a saturated or unsaturated, linear or branched, optionally at least mono-substituted aliphatic radical, or R9 and R10, together with the bridging nitrogen atom form a saturated or unsaturated, optionally at least mono-substituted, optionally at least one further heteroatom as a ring member containing heterocyclic ring which may be condensed with a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as a ring member containing mono- or bicyclic cycloaliphatic ring system, A and B, identical or different, each represent a saturated or unsaturated, linear or branched, optionally at least mono-substituted aliphatic radical or A and B, together with the carbon atom to which they are attached, form a saturated or unsaturated, but not aromatic, optionally at least mono-substituted cycloalkyl ring, and n is 0, 1,2, 3, or 4, optionally in form of one of their stereoisomers, preferably enantiomers or diastereomers, their racemate or in form of a mixture of at least two of their stereoisomers, preferably enantiomers or diastereomers, in any mixing ratio, or a salt thereof, preferably a corresponding physiologically acceptable salt thereof or a corresponding solvate thereof. Another aspect of the present invention are compounds of general formula (Ib) R2, R3, R4, R5 and R6, identical or different, each represent hydrogen, halogen, cyano, nitro, a saturated or unsaturated, linear or branched aliphatic radical, a linear or branched alkoxy radical, a linear or branched alkylthio radical, hydroxy, trifluoromethyl, a saturated or unsaturated cycloaliphatic radical, an alkylcarbonyl radical, a phenylcarbonyl or a -NR9R10 group, R7 and R8, identical or different, each represent hydrogen or a saturated or unsaturated, optionally at least mono-substituted linear or branched C-M aliphatic radical, R9 and R10, identical or different, each represent hydrogen or a saturated or unsaturated, linear or branched, optionally at least mono-substituted aliphatic radical, or R9 and R10, together with the bridging nitrogen atom form a saturated or unsaturated, optionally at least mono-substituted, optionally at least one further heteroatom as a ring member containing heterocyclic ring which may be condensed with a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as a ring member containing mono- or bicyclic cycloaliphatic ring system, A and B, identical or different, each represent a saturated or unsaturated, linear or branched, optionally at least mono-substituted aliphatic radical or A and B, together with the carbon atom to which they are attached, form a saturated or unsaturated, but not aromatic, optionally at least mono-substituted cycloalkyl ring, and nisO, 1, 2, 3 or 4; optionally in form of one of its stereoisomers, preferably enantiomers or diastereomers, their racemate or in form of a mixture of at least two of their stereoisomers, preferably enantiomers or diastereomers, in any mixing ratio, or a salt thereof, preferably a corresponding physiologically acceptable salt therof or a corresponding solvate thereof. Yet, another aspect of the present invention are compounds of general formula (Ic) R1 represents a -NR7RB radical or a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as a ring member containing cycloaliphatic radical, which may be condensed with a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as a ring member containing mono- or bicyclic cycloaliphatic ring system, R2, R3, R4, R5 and R6, identical or different, each represent hydrogen, halogen, cyano, nitro, a saturated or unsaturated, linear or branched aliphatic radical, a linear or branched alkoxy radical, a linear or branched alkylthio radical, hydroxy, trifluoromethyl, a saturated or unsaturated cycloaliphatic radical, an alkylcarbonyl radical, a phenylcarbonyl or a -NR9R10 group, R7 and R8, identical or different, each represent hydrogen or a saturated or unsaturated, optionally at least mono-substituted linear or branched aliphatic radical, or R7 and R8, together with the bridging nitrogen atom form a saturated or unsaturated, optionally at least mono-substituted, optionally at least one further heteroatom as a ring member containing heterocyclic ring which may be condensed with a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as a ring member containing mono- or bicyclic cycloaliphatic ring system, R9 and R10, identical or different, each represent hydrogen or a saturated or unsaturated, linear or branched, optionally at least mono-substituted aliphatic radical, or R9 and R10, together with the bridging nitrogen atom form a saturated or unsaturated, optionally at least mono-substituted, optionally at least one further heteroatom as a ring member containing heterocyclic ring which may be condensed with a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as a ring member containing mono- or bicyclic cycloaliphatic ring system, A and B, identical or different, each represent a saturated or unsaturated, linear or branched, optionally at least mono-substituted aliphatic radical or A and B, together with the carbon atom to which they are bonded, form a saturated or unsaturated, but not aromatic, optionally at least mono-substituted cycloalkyl ring, and nisO, 1,2, 3, or 4, optionally in form of one of their stereoisomers, preferably enantiomers or diastereomers, their racemate or in form of a mixture of at least two of their stereoisomers, preferably enantiomers or diastereomers, in any mixing ratio, or a salt thereof, preferably a corresponding physiologically acceptable salt thereof or a corresponding solvate thereof. If one or more of the moieties R2-R10, A and B, represent an alkyl radical, an alkenyl radical or an alkynyl radical, which is substituted by one or more substituents, each one of these substituents can preferably be chosen from the group consisting of hydroxy, halogen, linear or branched Ci-Ce alkyl, linear or branched Ci-Cealkoxy, linear or branched Ci-C6 perfluoroalkyl, linear or branched d-C6 perfluoroalkoxy, or an optionally at least mono-substituted phenyl radical. If said phenyl radical is substituted by one one or more substituents as well, each one of these substituents can preferably be chosen from the group consisting of fluorine, chlorine, bromine, a linear or branched Ci-Ce alkyl, a linear or branched Ci-Ce alkoxy, a linear or branched Ci-C6 alkylthio, a trifluoromethyl radical, a cyano radical and an NR11R12 radical, wherein R11 and If R1 is a saturated or unsaturated, optionally at least one heteroatom as a ring member containing cycloaliphatic radical, which is substituted by one or more substituents and/or if R1 comprises a saturated or unsaturated, optionally at least one heteroatom as a ring member containing mono- or bicyclicc cycloaliphatic ring system, which is substituted by one or more substituents, each one of these substituents can, unless defined otherwise, preferably be chosen from the group consisting of hydroxy, fluorine, chlorine, bromine, linear or branched d-Ce alkyl, linear or branched d-Ce alkoxy, linear or branched Ci-CB perfluoroalkyl, linear or branched d-Ceperfluoroalkoxy and benzyl, more preferably from the group consisting of linear or branched Ci-C6 alkyl and benzyl. The heteroatoms of the cycloaliphatic radical and/or of the mono- or bicyclicc cycloaliphatic ring can, independently from one another, preferably be chosen from the group consisting of nitrogen, sulphur and oxygen, more preferably nitrogen is chosen as a heteroatom. Said cycloaliphatic radical may contain 0,1, 2 or 3 heteroatoms chosen from the above mentioned group, preferably it contains 0,1 or 2 heteroatoms chosen from the above mentioned group. If R7 and R8 together with the bridging nitrogen form a saturated or unsaturated, optipnally at least one further heteroatom as a ring member containing heterocyclic ring, which is substituted by one or more substituents and/or condensed with a saturated or unsaturated, optionally at least one heteroatom as a ring member containing mono- or bicyclicc cycloaliphatic ring system, which is substituted by one or more substituents, each one of these substituents can, unless defined otherwise, preferably be chosen from the group consisting of hydroxy, fluorine, chlorine, bromine, linear or branched Cr Ce alkyl, linear or branched d-Ce alkoxy, linear or branched Ci-C6 perfluoroalkyl, linear or branched Ci-C6 perfluoroalkoxy and benzyl, more preferably from the group consisting of linear or branched Ci-Ce alkyl and benzyl. If the heterocyclic ring contains one or more additional heteroatoms, and/or if one or both mono- or bicyclic rings contain one or more heteroatoms, these heteroatoms can, independently from one another, preferably be chosen from the group consisting of nitrogen, sulphur and oxygen, more preferably nitrogen is chosen as a heteroatom. Said heterocyclic ring may contain 0, 1, 2 or 3 additional heteroatoms chosen from the above mentioned group, preferably it contains 0 or 1 heteroatoms chosen from the above mentioned group. If A is an aliphatic radical, i.e. an alkyl, alkenyl or alkynyl radical, substituted by one or more substituents, each one of these substituents can preferably be chosen from the group consisting of hydroxy, halogen, linear or branched C-i-Ce alkyl, linear or branched Ci-Cealkoxy, linear or branched C-i-Ce perfluoroalkyl, linear or branched Ci-Ce perfluoroalkoxy or an optionally at least mono-substituted phenyl radical. If said phenyl radical is substituted by one or more substituents as well, each one of these substituents can preferably be chosen from the group consisting of fluorine, chlorine, bromine, linear or branched Ci-C6 alkyl, linear or branched Ci-C6 alkoxy, linear or branched CrC6 alkylthio, a trifluoromethyl radical, a cyano radical and an NR13R14 radical, wherein R13 and R14, identical or different, are defined as R7and R8. If B is an aliphatic radical, i.e. an alkyl radical, an alkenyl radical or an alkynyl radical, which is substituted by one or more substituents, each one of these substituents can preferably be chosen from the group consisting of hydroxy, halogen, linear or branched C-i-C6 alkyl, linear or branched Ci-Ce alkoxy, linear or branched C-i-Ce perfluoroalkyl, linear or branched C-i-Ce perfluoroalkoxy, or an optionally at least mono-substituted phenyl radical. If said phenyl radical is substituted by one or more substituents as well, each one of the substituents can preferably be chosen from the group consisting of fluorine, chlorine, bromine, linear or branched Ci-C6 alkyl, linear or branched CrC6 alkoxy, linear or branched Ci-Ce alkylthio, a trifluoromethyl radical, a cyano radical and a NR15R16 radical, wherein R15 and R16, identical or different, are defined as R7 and R8. If A and B together with the carbon atom to which they are bonded form a saturated or unsaturated, but not aromatic, cycloalkyl ring, which is substituted by one or more substituents, each one of these substituents can preferably be chosen from the group consisting of hydroxy, halogen, linear or branched d-Ce alkyl, linear or branched Ci-Ce alkoxy, linear or branched Ci-Ce perfluoroalkyl, linear or branched Ci-Ce perfluoroalkoxy or an optionally at least mono-substituted phenyl radical. If said phenyl radical is substituted by one or more substituents as well, each one of these substituents can preferably be chosen from the group consisting of fluorine, chlorine, bromine, linear or branched Cf-Ce alkyl, linear or branched Cr C6 alkoxy, linear or branched Ci-Ce alkylthio, a trifluoromethyl radical, a cyano radical and a NR17R18 radical, wherein R17 and R18, identical or different, are defined as R7 and R8. If one of the substituents R2, R3, R4, R5 and R6 represents a linear or branched aliphatic radical, a linear or branched alkoxy radical or a linear or branched alkylthio radical, the carbon chain may have preferably 1-6, more preferably 1-3 carbon atoms. Those skilled in the art understand that the term "condensed" indicates that the condensed rings share more than one atom. The terms "annulated" or "fused" may also be used for this type of bonding. Sulfonamide derivatives of general formula (la) are preferred, wherein R1 represents a -NR7R8 radical or a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as a ring member containing 5- or 6-membered cycloaliphatic radical, which may be condensed with a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as a ring member containing mono- or bicyclic cycloaliphatic ring system, whereby the rings of the ring system are 5- or 6-membered, more preferably R1 represents a NR7R8 radical or a radical chosen from the group consisting of wherein, if present, the dotted line represents an optional chemical bond, and R19 represents hydrogen, a linear or branched C-i-Ce alkyl radical or a benzyl radical, preferably hydrogen or a Ci-C2 alkyl radical and R2-R6, R9, R10, A, B and n are defined as above. Sulfonamide derivatives of general formula (la) are also preferred, wherein R2, R3, R4, R5 and R6, identical or different, each represent hydrogen, F, Cl, Br, cyano, nitro, a linear or branched d-6 alkyl radical, a linear or branched C2.6 alkenyl radical, a linear or branched C2.6 aikynyl radical, a linear or branched Ci ealkoxy, a linear or branched Ci-6 alkylthio, hydroxy, trifluoromethyl, a saturated or unsaturated C3.8 cycloaliphatic radical, a linear or branched Ci-6 alkylcarbonyl radical, phenylcarbonyl or an -NR9R10 group, more preferably R2, R3, R4, R5 and R6, identical or different, each represent H, F, Cl, NO2, NH2 or a Ct-2 alkyl radical and R1, R7-R10, A, B and n are defined as above. Furthermore, sulfonamide derivatives of general formula (la) are also preferred, wherein R7 and R8, identical or different, each represent hydrogen, a linear or branched, optionally at least mono-substituted C-MO alkyl radical, a linear or branched, optionally at least mono-substituted C2-io alkenyl radical, or a linear or branched, optionally at least mono-substituted C2-io alkynyl radical.with the proviso that R8 and R9 are not hydrogen at the same time, and if one of them, R8 and R9, is a saturated or unsaturated, linear or branched, optionally at least mono-substituted, d-C4 aliphatic radical, the other one is a saturated or unsaturated, linear or branched, optionally at least mono-substituted aliphatic radical with at least five carbon atoms, or R7 and R8 together with the bridging nitrogen form a saturated or unsaturated, optionally at least mono-substituted, optionally at least one further heteroatom as a ring member containing 5- or 6-membered heterocyclic ring which may be condensed with a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as a ring member containing mono- or bicyclicc cycloaliphatic ring system, whereby the rings of the ring system are 5- 6- or 7-membered and R1-R6, R9, R10, A, B and n are defined as above. Particularly preferred are sulfonamide derivatives of general formula (la), wherein R7 and R8, identical or different, represent hydrogen or a linear or branched Ci-Ci0 alkyl radical, with the proviso that R8 and R9 are not hydrogen at the same time, and if one of them, R8 or R9, represents a saturated or unsaturated, linear or branched, optionally at least mono-substituted Ci-C4 aliphatic radical, the other one of them represents a saturated or unsaturated, linear or branched, optionally at least mono-substituted aliphatic radical with at least five carbon atoms, or R7 and R8 together with the bridging nitrogen atom form a radical chosen from the group consisting of wherein R20, if present, represents hydrogen, a linear or branched C-i-Ce alkyl radical or a benzyl radical, preferably hydrogen, or a Ci-C2 alkyl radical, and R1-R6, R9, R10, A, B and n are defined as above. Furthermore, sulfonamide derivatives of general formula (la) are also preferred, wherein R9 and R10, identical or different, identical or different, each represent hydrogen, a linear or branched, optionally at least mono-substituted d-C-io alkyl radical, a linear or branched, optionally at least mono-substituted C2-Cio alkenyl radical or a linear or branched, optionally at least mono-substituted C2-Cio alkynyl radical or R9 and R10, together with bridging nitrogen atom form a saturated or unsaturated, optionally at least mono-substituted, optionally at least one further heteroatom as a ring member containing 5- or 6-membered heterocyclic ring, which may be condensed with a saturated or unsaturated, optionally at least mono-substituted,, optionally at least one heteroatom as a ring member containing mono- or bicyclicc cycloaliphatic ring system whereby the rings of the ring system are 5- 6- or 7-membered and R1-R8, A, B and n are defined as above. Particularly preferred are sulfonamide derivatives of general formula (la), wherein R9 and R10, identical or different, each represent hydrogen or a linear or branched C-i-Cio alkyl radical, or R9 and R10, together with the bridging nitrogen atom form a radical chosen from the group consisting of wherein R20, if present, represents hydrogen, a linear or branched C-i-Ce alkyl radical or a benzyl radical, preferably hydrogen, or a CrC2 alkyl radical, and R1-R8, A, B and n are defined as above. Furthermore, sulfonamide derivatives of general formula (la) are preferred, wherein A and B, identical or different, each represent a linear or branched C-i. C6 alkyl radical, a linear or branched C2-C6 alkenyl radical or a linear or branched Ca-Ce alkynyl radical, more preferably A and B, identical or different, each represent a linear or branched d-Ce alkyl radical, or A and B, together with the carbon atom to which they are bonded, form a saturated or unsaturated, but not aromatic, optionally at least mono-substituted cycloalkyl ring, more preferably A and B together with the carbon atom to which they are bonded form a Ca-Cs cycloalkyl ring, even more preferably A and B together with the carbon atom to which they are bonded form a cyclohexyl ring Furthermore sulfonamide derivatives of general formula (la) are preferred, wherein n is 0,1, 2, 3 or 4; preferably n is 0 or 1; more preferably n is 0 and R1 to R10 and A and B are defined as above. Those most preferred compounds of general formula (la) are selected from the group consisting of [1] 1-Cydohexanesulfonyl-3-(1-methyl-1,2,3,6-tetrahydropyridine-4-yl)-5-nitro-1 H-indole, [2] 5-Chloro-1 -cyclohexanesulfonyl-3-(1 -methyl-1,2,3,6-tetrahydropyridine-4-yl)-1 H-indole, [3] 5-Amino-1 -cyclohexanesulfonyl-3-(1 -methyl-1,2,3,6-tetrahydropyridine-4-yl)-1 H-indole and [4] 1 -Cyclohexanesulfonyl-5-fluoro-3-(1,2,3,5,8,8a-hexahydro-indolizine-7-yl)-1H-indoie hydrochloride and their corresponding salts and solvates. Sulfonamide derivatives of general formula (Ib) are also preferred, wherein R2, R3, R4, R5and R6, identical or different, each represent hydrogen, F, Cl, Br, cyano, nitro, a linear or branched C-i-e alkyl radical, a linear or branched C2-6alkenyl radical, a linear or branched C2-6alkynyl radical, linear or branched C-i-e-alkoxy, a linear or branched Ci_6-alkylthio radical, hydroxy, trifluoromethyl, a saturated or unsaturated C3-a cycloaliphatic radical, a linear or branched Ci-e-alkylcarbonyl radical, phenylcarbonyl or a -NR9R10 group, preferably R2, R3, R4, R5and R6, identical or different, each represent H, F, Cl, NO2, NH2 or a Ci.2aikyl radical, and R1, R7-R10, A, B and n are defined as above. Furthermore, sulfonamide derivatives of general formula (Ib) are also preferred, wherein R7 and R8, identical or different, each represent hydrogen, a linear or branched, optionally at least mono-substituted C-|.C4 alkyl radical and R1-R6, R9, R10, A, B and n are defined as above. Particularly preferred are sulfonamide derivatives of general formula (Ib), wherein R7 and R8, identical or different, each represent hydrogen or a CrC2 alkyl radical, with the proviso that R7and R8 are not hydrogen at the same time, and R1-R6, R9, R10, A, B and n are defined as above. Furthermore, sulfonamide derivatives of general formula (Ib) are also preferred, wherein R9 and R10, identical or different, each represent hydrogen, a linear or branched, optionally at least mono-substituted Ct-Cio alkyl radical, a linear or branched, optionally at least mono-substituted C2-Ci0 alkenyl radical or a linear or branched, optionally at least mono-substituted C2-Cio alkynyl radical or R9 and R10, together with the bridging nitrogen atom form a saturated or unsaturated, optionally at least mono-substituted, optionally at least one further heteroatom as a ring member containing 5- or 6-membered heterocyclic ring, which may be condensed with a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as a ring member containing mono- or bicyclicc cycloaliphatic ring system whereby the rings of the ring system are 5- 6- or 7-membered and R1-R8, A, B and n are defined as above. Particularly preferred are sulfonamide derivatives of general formula (Ib), wherein R9 and R10, identical or different, each represent hydrogen or a linear or branched Ci-C-io alkyl radical, or R9 and R10, together with the bridging nitrogen form a radical chosen from the group consisting of wherein R20, if present, represents hydrogen, a linear or branched C-i-Ce alkyl radical or a benzyl radical, preferably hydrogen, or a Ci-Ca alkyl radical, and R1-R8, A, B and n are defined as above. Furthermore, sulfonamide derivatives of general formula (Ib) are preferred, wherein A and B, identical or different, each represent a linear or branched CrCe alkyl radical, a linear or branched CrC6 alkenyl radical, or a linear or branched CrCe alkynyl radical, preferably a linear or branched CrCe alkyl radical, or A and B, together with the carbon atom to which they are bonded, form a saturated or unsaturated, but not aromatic, optionally at least mono-substituted cycloalkyl ring, more preferably A and B together with the carbon atom to which they are bonded form a Ca-Cs cycloalkyl ring, even more preferably A and B together with the carbon atom to which they are bonded form a cyclohexyl ring and R1-R10and n are defined as above. Furthermore sulfonamide derivatives of general formula (Ib) are preferred, wherein n is 0, 1, 2, 3 or 4; preferably n is 0 or 1; more preferably n is 0 and R1 to R10 and A and B are defined as above. Sulfonamide derivatives of general formula (Ic) are preferred, wherein R1 represents a -NR7R8 radical or a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as a ring member containing 5- or 6-membered cycloaliphatic radical, which may be condensed with a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as a ring member containing mono- or bicyclic cycloaliphatic ring system, whereby the rings of the ring system are 5- or 6-membered, more preferably R1 represents a NR7R8 radical or a radical chosen from the group consisting of wherein, if present, the dotted line represents an optional chemical bond, and R19 represents hydrogen, a linear or branched CrCe alkyl radical or a benzyl radical, preferably hydrogen or a C1-C2 alkyl radical and R2-R6, R9, R10, A, B and n are defined as above. Sulfonamide derivatives of general formula (Ic) are also preferred, wherein R2, R3, R4, R5 and R6, identical or different, each represent hydrogen, F, Cl, Br, cyano, nitro, a linear or branched C1-6 alkyl radical, a linear or branched C2.6 alkenyl radical, a linear or branched C2-6 alkynyl radical, a linear or branched C1-6alkoxy, a linear or branched C1-6alkylthio, hydroxy, trifluoromethyl, a saturated or unsaturated CS-B cycloaliphatic radical, a linear or branched C1-6 alkylcarbonyl radical, phenylcarbonyl or an -NR9R10 group, more preferably R2, R3, R4, R5 and R6, identical or different, each represent H, F, Cl, NO2, NH2 or a Ci_2 alkyl radical and R1, R7-R10, A, B and n are defined as above. Furthermore, sulfonamide derivatives of general formula (Ic) are also preferred, wherein R7 and R8, identical or different, each represent hydrogen, a linear or branched, optionally at least mono-substituted CMO alkyl radical, a linear or branched, optionally at least mono-substituted,62-10 alkenyl radical, or a linear or branched, optionally at least mono-substituted.Ca-io alkynyl radical, or R7 and R8 together with the bridging nitrogen form a saturated or unsaturated, optionally at least mono-substituted, optionally at least one further heteroatom as a ring member containing 5- or 6-membered heterocyclic ring which may be condensed with a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as a ring member containing mono- or bicyclicc cycloaliphatic ring system, whereby the rings of the ring system are 5- 6- or 7-membered and R1-R6, R9, R10, A, B and n are defined as above. Particularly preferred are sulfonamide derivatives of general formula (Ic), where R7 and R8, identical or different, represent hydrogen or a linear or branched CrC-io alkyl radical, or R7 and R8 together with the bridging nitrogen atom form a radical chosen from the group consisting of wherein R20, if present, represents hydrogen, a linear or branched C-i-C6 alkyl radical or a benzyl radical, preferably hydrogen, or a C1-C2 alkyl radical, and R1-R6, R9, R10, A, B and n are defined as above. Furthermore, sulfonamide derivatives of general formula (Ic) are also preferred, wherein R9 and R10, identical or different, identical or different, each represent hydrogen, a linear or branched, optionally at least mono-substituted C1-C-10 alkyl radical, a linear or branched, optionally at least mono-substituted C3-C10 alkenyl radical or a linear or branched, optionally at least mono-substituted C3-C10 i alkynyl radical or R9 and R10, together with bridging nitrogen atom form a saturated or unsaturated, optionally at least mono-substituted, optionally at least one further heteroatom as a ring member containing 5- or 6-membered heterocyclic ring, which may be condensed with a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as a ring member containing mono- or bicyclicc cycloaliphatic ring system whereby the rings of the ring system are 5- 6- or 7-membered and R1-R8, A, B and n are defined as above. Particularly preferred are sulfonamide derivatives of general formula (Ic), wherein R9 and R10, identical or different, each represent hydrogen or a linear or branched C-i-Cio alky! radical, or R9 and R10, together with the bridging nitrogen atom form a radical chosen from the group consisting of wherein R20, if present, represents hydrogen, a linear or branched CrC6 alkyl radical or a benzyl radical, preferably hydrogen, or a CrC2 alkyl radical, and R1-R8, A, B and n are defined as above. Furthermore, sulfonamide derivatives of general formula (Ic) are preferred, wherein A and B, identical or different, each represent a linear or branched G-I, C6 alkyl radical, a linear or branched C2.C6 alkenyl radical or a linear or branched C2-C6 alkynyl radical, more preferably A and B, identical or different, each represent a linear or branched Ci.Ce alkyl radical, or A and B, together with the carbon atom to which they are bonded, form a saturated or unsaturated, but not aromatic, optionally at least mono-substituted cycloalkyi ring, more preferably A and B together with the carbon atom to which they are bonded form a Ca-Cs cycloalkyi ring, even more preferably A and B together with the carbon atom to which they are bonded form a cyclohexyl ring and R1-R10and n are defined as above. Furthermore sulfonamide derivatives of general formula (Ic) are preferred, wherein n is 0, 1, 2, 3 or 4; preferably n is 0 or 1; more preferably n is 0 and R1 to R10 and A and B are defined as above. R1 represents an unsaturated, optionally at least one nitrogen atom as a ring member containing 5- or 6-membered cycloaliphatic radical, which may be substituted by a methyl group and/or which may be condensed with a 5-membered cycloaliphatic ring, more preferably R1 represents a -NR7R8 radical or a moiety selected from the group consisting of R2, R3, R4 and R6 each represent hydrogen, R5 represents H, fluorine, chlorine, nitro or a -NR9R10 group, R9 and R10each represent hydrogen, A and B together with the carbon atom to which they are bonded form a saturated or unsaturated, but not aromatic, Ca-Cs cycloalkyl ring, more preferably form a cyclohexyl ring, and n isO; optionally in form of one of their stereoisomers, preferably enantiomers or diastereomers, their racemate or in form of a mixture of at least two of their stereoisomers, preferably enantiomers or diastereomers, in any mixing ratio, or a salt thereof, preferably a corresponding physiologically acceptable salt thereof or a corresponding solvate thereof. Those most preferred compounds of general formula (Ic) are selected from the group consisting of [1] l-Cyclohexanesulfonyl-S^I-methyl-I^.S.G-tetrahydropyridine^-yO-S-nitro-1 H-indole, [2] 5-Chloro-1 -cyclohexanesulfonyl-3-(1 -methyl-1,2,3,6-tetrahydropyridine-4-yl)-1 H-indole, [3] 5-Amino-1-cyclohexanesulfonyl-3-(1 -methyl-1,2,3,6-tetrahydropyridine-4-yl)-1 H-indole and [4] 1 -Cyclohexanesulfonyl-5-fluoro-3-(1,2,3,5(8,8a-hexahydro-indolizine-7-yl)-1 H-indole hydrochloride and their corresponding salts and solvates. The present invention likewise refers to the salts, preferably the physiologically acceptable salts of the compounds of general formula (la) and/or (Ib) and/or of general formula (Ic), preferably the addition salts of mineral acids, more preferably of hydrochloric acid, hydrobromic acid acid, phosphoric acid, sulphuric acid, nitric acid, and the salts of organic acids, more preferably of citric acid, maleic acid acid, fumaric acid, tartaric acid or their derivatives, p-toluenesulphonic acid, methanesulphonic acid, camphorsulphonic acid, etc. Below, the expression sulfonamide derivatives of general formula (I) refers to one or more compounds of general formula (la) and/or to one or more compounds of general formula (Ib) and/or to one or more compounds of general formula (Ic), respectively and optionally in form of one of their stereoisomers, preferably enantiomers or diastereomers, their racemate, or in form of a mixture of at least two of their stereoisomers, preferably enantiomers or diastereomers, in any mixing ratio, or a salt thereof, preferably a corresponding physiologically acceptable salt thereof, or a corresponding solvate thereof. Another aspect of the present invention consists of a process for preparing the new derivatives of general formula (I), wherein R1-R10, A, B and n have the previously indicated meaning, according to which at least one compound of general formula (II). wherein A and B have the previously mentioned meaning and X is an acceptable leaving group, preferably an halogen atom, more preferably chlorine, is reacted with at least one substituted indole of general formula (III) wherein R1-R6 and n have the previously indicated meaning, or one of their suitable protected derivatives, and, if necessary, the protective groups are * removed in order to obtain the corresponding sulfonamide derivative of formula (I), which can be purified and/or isolated by means of conventional methods known in the prior art. The reaction is preferably carried out in the presence of a suitable strong base, for example, lithium diisopropylamide, butyllithium, sodium hydride, or sodium bis(trimethylsilyl)amide in an inert solvent, preferably tetrahydrofurane, hexane or dimethylformamide. The most suitable reaction temperatures range from -100°C to room temperature, and the reaction time preferably comprises from 5 minutes to 24 hours. The most preferred conditions are sodium hydride in dimethylformamide at approximately 0°C. The resulting sulfonamide derivative of general formula (I) can be purified and/or isolated according to conventional methods known in the prior art. Preferably, the sulfonamide derivatives of general formula (I) can be isolated by evaporating the reaction medium, adding water and, if necessary, adjusting the pH so that a solid which can be isolated by filtration is obtained; or the sulfonamide derivatives can be extracted with a water immiscible solvent, preferably chloroform, and be purified by chromatography or recrystallization of a suitable solvent. The compounds of general formula (II) are commercially available or can be prepared according to standard methods known in the prior art, for example by methods similar to those described in the literature [KHANNA, V.; TAM1LSELVAN, P.; KALRA, S.J.S.; IQBAL, J.; Tetrahedron 1994, 35 (32), 5935-5938; L.N. Aristarkhova etal., J. Org. Chem. USSR, 1970, 6, 2454-2458; E.E. Gilbert, Synthesis, 1969, 1,3]. The compounds of general formula (III) can also be prepared according to standard methods known in the prior art, for example, methods similar to those described in the literature. Substituted aromatic 5-HT1f agonist, WO9846570. Piperidine-indole compounds having 5-HT6 affinity, US 6,133,287. The respective descriptions in the literature are incorporated by reference and form part of the disclosure. Another aspect of the present invention consists of a process for preparing the new sulfonamide derivatives of general formula (I), wherein one or more of R2, R3, R4, R5 or R6 are reducet to an amino group by reduction of the nitro group of derivatives of general formula (IV) by methods known in the prior art, for example BRATTON, L.D.; ROTH, B.D.; TRIVEDI, B.K.; UNANGST, P.C.; J. Heterocycl Chem, 2000, 37 (5), 1103-1108. FANGHAENEL, E.; CHTCHEGLOV, D.; J Prakt Chem/Chem-Ztg, 1996, 338 (8), 731-737. KUYPER, L.F.; BACCANARI, DP.; JONES, M.L; HUNTER, R.N.; TANSIK, R.L.; JOYNER, S.S.; BOYTOS, C.M.; RUDOLPH, S.K.; KNICK, V.; WILSON, H.R.; CADDELL, J.M.; FRIEDMAN, H.S.; ETAL; J Med Chem, 1996, 39 (4), 892-903, and the others R1-R6, A, B and n have the previously mentioned meaning, or one of their derivatives suitably protected, and, if necessary, the protective groups are removed in order to obtain the corresponding amine of general formula (I), which can be purified and/or isolated by means of conventional methods known in the prior art. The respective literature descriptions are incorporated by reference and form part of the disclosure. The salts, preferably pharmaceutically acceptable salts of the compounds of general formula (I), may be prepared by means of conventional methods known in the prior art, preferably by reaction with a mineral acid, more preferably by reaction with hydrochloric acid, hydrobromic acid, phosphoric acid acid, sulphuric acid or nitric acid, or by reaction with organic acids, more preferably by reaction with citric acid, maleic acid, fumaric acid acid, tartaric acid, or their derivatives, p-toluenesulphonic acid, methanesulphonic acid, camphorsulphonic acid, etc., in a suitable solvent, preferably methanol, ethanol, diethyl ether, ethyl acetate, acetonitrile or acetone, and obtaining the resulting salts by using the usual techniques for the precipitation or crystallization of the corresponding salts. The preferred physiologically acceptable salts of the sulfonamide derivatives of general formula (I) are the addition salts of mineral acids, more preferably of hydrochloric acid, hydrobromic acid, phosphoric acid, sulphuric acid acid or nitric acid, and the addition salts of organic acids, more preferably 1 citric acid, maleic acid, fumaric acid, tartaric acid, or their derivatives, p-toluenesulphonic acid, methanesulphonic acid, camphorsulphonic acid, etc. The solvates, preferably the physiologically acceptable solvates, more preferably hydrates, of the sulfonamide derivatives of general formula (I) or of the corresponding physiologically acceptable salts, may be prepared by methods known in the prior art. During some of the synthetic sequences described or in the preparation of the suitable reagents used, it may be necessary and/or desirable to protect sensitive or reactive groups in some of the molecules used. This can be carried out by means of the use of conventional protective groups preferably those described in the literature [Protective groups in Organic Chemistry, ed. J.F.W. McOmie, Plenum Press, 1973; T.W. Greene & P.G.M. Wuts, Protective Groups in Organic Chemistry, John Wiley & Sons, 1991]. The protective groups can be removed in the suitable subsequent stage by methods known in the prior art. The respective literature descriptions are incorporated by reference and form part of the disclosure. If the sulfonamide derivatives of general formula (I) are obtained in form of a mixture of stereoisomers, preferably enantiomers or diastereomers, said mixtures can be separated by means of standard processes known in the prior art, for example chromatographic methods or crystallization with chiral agents. Another aspect of the present invention is a medicament comprising at least one 1-sulfonylindole derivative of general formula (I), optionally in form of one of its stereoisomers, preferably enantiomers or diastereomers, its racemate, or in form of a mixture of at least two of its stereoisomers, preferably enantiomers or diastereomers, in any mixing ratio, or a corresponding physiologically acceptable salt thereof or a corresponding solvate thereof, and optionally one or more pharmaceutically acceptable adjuvants. This medicament is suitable for 5-HTe receptor regulation, for the prophylaxis and/or treatment of a disorder or disease related to food intake, preferably for the regulation of appetite, for the maintenance, increase or reduction of body weight, for the prophylaxis and/or treatment of obesity, bulimia, anorexia, cachexia or type II diabetes (non insulin dependent diabetes mellitus), preferably type II diabetes caused by obesity, for the prophylaxis and/or treatment of gastrointestinal tract disorders, preferably irritable bowel syndrome, for cognitive enhancement, for the prophylaxis and/or treatment of disorders of the central nervous system, anxiety, panic disorders, depression, preferably bipolar disorders, cognitive memory disorders, senile dementia processes, neurodegenerative disorders, preferably Alzheimer's disease, Parkinson's disease, Huntington's disease and/or Multiple Sclerosis, schizophrenia, psychosis or infantile hyperkinesia (ADHD, attention deficit / hyperactivity disorder) and other disorders mediated by the 5-HT6 serotonin receptor in humans and/or in animals, preferably in mammals, more preferably in humans. Another aspect of the present invention is a medicament comprising at least one 1-sulfonylindole derivative of general formula (la), optionally in form of one of its stereoisomers, preferably enantiomers or diastereomers, its racemate, or in form of a mixture of at least two of its stereoisomers, preferably enantiomers or diastereomers, in any mixing ratio, or a corresponding physiologically acceptable salt thereof or a corresponding solvate thereof, and optionally one or more pharmaceutically acceptable adjuvants. This medicament is suitable for 5-HTe receptor regulation, for the prophylaxis and/or treatment of a disorder or disease related to food intake, preferably for the regulation of appetite, for the maintenance, increase or reduction of body weight, for the prophylaxis and/or treatment of obesity, bulimia, anorexia, cachexia or type II diabetes (non insulin dependent diabetes mellitus), preferably type II diabetes caused by obesity, for the prophylaxis and/or treatment of gastrointestinal tract disorders, preferably irritable bowel syndrome, for cognitive enhancement, for the prophylaxis and/or treatment of disorders of the central nervous system, anxiety, panic disorders, depression, preferably bipolar disorders, cognitive memory disorders, senile dementia processes, neurodegenerative disorders, preferably Alzheimer's disease, Parkinson's disease, Huntington's disease and/or Multiple Sclerosis, schizophrenia, psychosis or infantile hyperkinesia (ADHD, attention deficit / hyperactivity disorder), and other disorders mediated by the 5-HT6 serotonin receptor in humans and/or in animals, preferably in mammals, more preferably in humans, more suitable for 5-HTe receptor regulation, for the prophylaxis and/or treatment of a disorder or disease related to food intake, preferably for the regulation of appetite, for the maintenance, increase or reduction of body weight, for the prophylaxis and/or treatment of obesity, bulimia, anorexia, cachexia or type II diabetes (non insulin dependent diabetes mellitus), preferably type II diabetes caused by obesity, for the prophylaxis and/or treatment of gastrointestinal tract disorders, preferably irritable bowel syndrome in humans and/or in animals, preferably in mammals, more preferably in humans. Another aspect of the present invention is a medicament comprising at least one 1-sulfonylindole derivative of general formula (Ib), optionally in form of one of its stereoisomers, preferably enantiomers or diastereomers, its racemate, or in form of a mixture of at least two of its stereoisomers, preferably enantiomers or diastereomers, in any mixing ratio, or a corresponding physiologically acceptable salt thereof or a corresponding solvate thereof, and optionally one or more pharmaceutically acceptable adjuvants. This medicament is suitable for 5-HTe receptor regulation, for the prophylaxis and/or treatment of a disorder or disease related to food intake, preferably for the regulation of appetite, for the maintenance, increase or reduction of body weight, for the prophylaxis and/or treatment of obesity, bulimia, anorexia, cachexia or type II diabetes (non insulin dependent diabetes mellitus), preferably type II diabetes caused by obesity, for the prophylaxis and/or treatment of gastrointestinal tract disorders, preferably irritable bowel syndrome, for cognitive enhancement, for the prophylaxis and/or treatment of disorders of the central nervous system, anxiety, panic disorders, depression, preferably bipolar disorders, cognitive memory disorders, senile dementia processes, neurodegenerative disorders, preferably Alzheimer's disease, Parkinson's disease, Huntington's disease and/or Multiple Sclerosis, schizophrenia, psychosis or infantile hyperkinesia (ADHD, attention deficit I hyperactivity disorder), and other disorders mediated by the 5-HTe serotonin receptor in more suitable for for cognitive enhancement, for the prophylaxis and/or treatment of disorders of the central nervous system, anxiety, panic disorders, depression, preferably bipolar disorders, cognitive memory disorders, senile dementia processes, neurodegenerative disorders, preferably Alzheimer's disease, Parkinson's disease, Huntington's disease and/or Multiple Sclerosis, schizophrenia, psychosis or infantile hyperkinesia (ADHD, attention deficit / hyperactivity disorder) in humans and/or in animals, preferably in mammals, more preferably in humans. Another aspect of the present invention is a medicament composed of at least one 1-sulfonylindole derivative of general formula (Ic), optionally in form of one of its stereoisomers, preferably enantiomers or diastereomers, its racemate, or in form of a mixture of at least two of its stereoisomers, preferably enantiomers or diastereomers, in any mixing ratio, or a corresponding physiologically acceptable salt thereof or a corresponding solvate thereof, and optionally one or more pharmaceutically acceptable adjuvants. This medicament is suitable for 5-HTe receptor regulation, for the prophylaxis and/or treatment of a disorder or disease related to food intake, preferably for the regulation of appetite, for the maintenance, increase or reduction of body weight, for the prophylaxis and/or treatment of obesity, bulimia, anorexia, cachexia or type II diabetes (non insulin dependent diabetes mellitus), preferably type II diabetes caused by obesity, for the prophylaxis arid/or treatment of gastrointestinal tract disorders, preferably irritable bowel syndrome, for cognitive enhancement, for the prophylaxis and/or treatment of disorders of the central nervous system, anxiety, panic disorders, depression, preferably bipolar disorders, cognitive memory disorders, senile dementia processes, neurodegenerative disorders, preferably Alzheimer's disease, Parkinson's disease, Huntington's disease and/or Multiple Sclerosis, schizophrenia, psychosis or infantile hyperkinesia (ADHD, attention deficit / hyperactivity disorder), and other disorders mediated by the 5-HT6 serotonin receptor in humans and/or in animals, preferably in mammals, more preferably in humans. The medicament obtained according to the present invention is particularly suitable for the administration to mammals, including humans. The medicament can preferably be administered to all age groups, namely, children, adolescents and adults. Another aspect of the present invention is the use of at least one sulfonamide derivative of general formula (I), optionally in form of one of its stereoisomers, preferably enantiomers or diastereomers, its racemate, or in form of a mixture of at least two of its stereoisomers, preferably enantiomers or diastereomers, in any mixing ratio, or a corresponding physiologically acceptable salt thereof or a corresponding solvate thereof, for the manufacture of a medicament for for 5-HTe receptor regulation, for the prophylaxis and/or treatment of a disorder or disease related to food intake, preferably for the regulation of appetite, for the maintenance, increase or reduction of body weight, for the prophylaxis and/or treatment of obesity, bulimia, anorexia, cachexia or type II diabetes (non insulin dependent diabetes mellitus), preferably type II diabetes caused by obesity, for the prophylaxis and/or treatment of gastrointestinal tract disorders, preferably irritable bowel syndrome, for cognitive enhancement, for the prophylaxis and/or treatment of disorders of the central nervous system, anxiety, panic disorders, depression, preferably bipolar disorders, cognitive memory disorders, senile dementia processes, neurodegenerative disorders, preferably Alzheimer's disease, Parkinson's disease, Huntington's disease and/or Multiple Sclerosis, schizophrenia, psychosis or infantile hyperkinesia (ADHD, attention deficit / hyperactivity disorder) and other disorders mediated by the 5-HTe serotonin receptor in humans and/or in animals, preferably in mammals, more preferably in humans. Another aspect of the present invention is the use of at least one sulfonamide derivative of the previous general formula (la), optionally in form of one of its stereoisomers, preferably enantiomers or diastereomers, its racemate, or in form of a mixture of at least two of its stereoisomers, preferably enantiomers or diastereomers, in any mixing ratio, or a corresponding physiologically acceptable salt thereof or a corresponding solvate thereof, for the manufacture of a medicament for 5-HT6 receptor regulation, for the prophylaxis and/or treatment of a disorder or disease related to food intake, preferably for the regulation of appetite, for the maintenance, increase or reduction of body j weight, for the prophylaxis and/or treatment of obesity, bulimia, anorexia, cachexia or type II diabetes (non insulin dependent diabetes mellitus), preferably type II diabetes caused by obesity, for the prophylaxis and/or treatment of gastrointestinal tract disorders, preferably irritable bowel syndrome, for cognitive enhancement, for the prophylaxis and/or treatment of disorders of the central nervous system, anxiety, panic disorders, depression, preferably bipolar disorders, cognitive memory disorders, senile dementia processes, neurodegenerative disorders, preferably Alzheimer's disease, Parkinson's disease, Huntington's disease and/or Multiple Sclerosis, schizophrenia, psychosis or infantile hyperkinesia (ADHD, attention deficit / hyperactivity disorder) and other disorders mediated by the 5-HTe serotonin receptor in humans and/or in animals, preferably in mammals, more preferably in humans, preferably for the manufacture of a medicament for 5-HTe receptor regulation, for the prophylaxis and/or treatment of a disorder or disease related to food intake, preferably for the regulation of appetite, for the maintenance, increase or reduction of body weight, for the prophylaxis and/or treatment of obesity, bulimia, anorexia, cachexia or type II diabetes (non insulin dependent diabetes mellitus), preferably type II diabetes caused by obesity, for the prophylaxis and/or treatment of gastrointestinal tract disorders, preferably irritable bowel syndrome receptor in humans and/or in animals, preferably in mammals, more preferably in humans. Another aspect of the present invention is the use of at least one suifonamide derivative of the previous general formula (Ib), optionally in form of one of its stereoisomers, preferably enantiomers or diastereomers, its racemate, or in form of a mixture of at least two of its stereoisomers, preferably enantiomers or diastereomers, in any mixing ratio, or a corresponding physiologically acceptable salt thereof or a corresponding solvate thereof, for the manufacture of a medicament for 5-HTe receptor regulation, for the prophylaxis and/or treatment of a disorder or disease related to food intake, preferably for the regulation of appetite, for the maintenance, increase or reduction of body weight, for the prophylaxis and/or treatment of obesity, bulimia, anorexia, cachexia or type II diabetes (non insulin dependent diabetes mellitus), preferably type II diabetes caused by obesity, for the prophylaxis and/or treatment of gastrointestinal tract disorders, preferably irritable bowel syndrome, for cognitive enhancement, for the prophylaxis and/or treatment of disorders of the central nervous system, anxiety, panic disorders, depression, preferably bipolar disorders, cognitive memory disorders, senile dementia processes, neurodegenerative disorders, preferably Alzheimer's disease, Parkinson's disease, Huntington's disease and/or Multiple Sclerosis, schizophrenia, psychosis or infantile hyperkinesia (ADHD, attention deficit / hyperactivity disorder) and other disorders mediated by the 5-HTe serotonin receptor in humans and/or in animals, preferably in mammals, more preferably in humans, preferably for the manufacture of a medicament for cognitive enhancement, for the prophylaxis and/or treatment of disorders of the central nervous system, anxiety, panic disorders, depression, preferably bipolar disorders, cognitive memory disorders, senile dementia processes, neurodegenerative disorders, preferably Alzheimer's disease, Parkinson's disease, Huntington's disease and/or Multiple Sclerosis, schizophrenia, psychosis or infantile hyperkinesia (ADHD, attention deficit / hyperactivity disorder) in animals, preferably in mammals, more preferably in humans. Another aspect of the present invention is the use of at least one sulfonamide derivative of the previous general formula (Ic), optionally in form of one of its stereoisomers, preferably enantiomers or diastereomers, its racemate, or in form of a mixture of at least two of its stereoisomers, preferably enantiomers or diastereomers, in any mixing ratio, or a corresponding physiologically acceptable salt thereof or a corresponding solvate thereof, for the manufacture of a medicament for 5-HT6 receptor regulation, for the prophylaxis and/or treatment of a disorder or disease related to food intake, preferably for the regulation of appetite, for the maintenance, increase or reduction of body weight, for the prophylaxis and/or treatment of obesity, bulimia, anorexia, cachexia or type II diabetes (non insulin dependent diabetes mellitus), preferably type II diabetes caused by obesity, for the prophylaxis and/or treatment of gastrointestinal tract disorders, preferably irritable bowel syndrome, for cognitive enhancement, for the prophylaxis and/or treatment of disorders of the central nervous system, anxiety, panic disorders, depression, preferably bipolar disorders, cognitive memory disorders, senile dementia processes, neurodegenerative disorders, preferably Alzheimer's disease, Parkinson's disease, Huntington's disease and/or Multiple Sclerosis, schizophrenia, psychosis or infantile hyperkinesia (ADHD, attention deficit / hyperactivity disorder) and other disorders mediated by the 5-HT6 serotonin receptor in humans and/or in animals, preferably in mammals, more preferably in humans. The preparation of the corresponding pharmaceutical compositions as v well as of the formulated medicaments can be carried out by means of conventional methods known in the prior art, for example, based on the indices of "Pharmaceutics: The Science of Dosage Forms", Second Edition, Aulton, M.E. (ED. Churchill Livingstone, Edinburgh (2002)); "Encyclopedia of Pharmaceutical Technology", Second Edition, Swarbrick, J. and Boylan, J.C. (Eds.), Marcel Dekker, Inc. New York (2002); "Modern Pharmaceutics", Fourth Edition, Banker G.S. and Rhodes C.T. (Eds.) Marcel Dekker, Inc. New York (2002), and."The Theory and Practice of Industrial Pharmacy", Lachman L, Lieberman H. and Kanig J. (Eds.), Lea & Febiger, Philadelphia (1986). The respective literature descriptions are incorporated as a reference and are part of this disclosure. The pharmaceutical compositions, as well as the formulated medicaments prepared according to the present invention, can, in addition to at least one sulfonamide derivative of general formula (I), optionally in form of one of its stereoisomers, preferably enantiomers or diastereomers, its racemate, or in form of a mixture of at least two of its stereoisomers, preferably enantiomers or diastereomers, in any mixing ratio, or a corresponding physiologically acceptable salt thereof or a corresponding solvate thereof, comprise other conventional auxiliary substances known in the prior art, preferably excipients, fillers, solvents, diluents, dyes, coating agents, matrix forming agents and/or binders. As those skilled in the art also know the choice of the auxiliary substances and the amounts thereof depends on the intended administration route, for example, rectal, intravenous, intraperitoneal, intramuscular, intranasal, oral, buccal or topical. Medicaments suitable for oral administration are, for example, tablets, coated tablets, capsules or multiparticulates, preferably granules or pellets, optionally subjected to compression in tablets, filled in capsules or suspended in solutions, suspensions or suitable liquids. Medicaments suitable for parenteral, topical or inhalatory administration can preferably be chosen from the group consisting of solutions, suspensions, quickly reconstitutable dry preparations and also sprays. Medicaments suitable for oral or percutaneous use can release the sulfonamide compounds of general formula (I) in a sustained manner, the preparation of these sustained release medicaments generally being known in the prior art. The most suitable sustained release forms, as well as the materials and methods for the preparation thereof, are known in the prior art, for example from the indices of "Modified-Release Drug Delivery Technology", Rathbone, MJ, Hadgraft, J. and Roberts, M.S. (Eds.), Marcel Dekker, Inc., New York (2002); "Handbook of Pharmaceutical Controlled Release Technology", Wise, D.L. (Ed.), Marcel Dekker, Inc. New York (2000); "Controlled Drug Delivery", Vol. I, Basic Concepts, Bruck, S.D. (Ed.), CRD Press, Inc., Boca Raton (1983), and by Takada, K. and Yoshikawa, H., "Oral Drug Delivery", Encyclopedia of Controlled Drug Delivery, Mathiowitz, E. (Ed.), John Wiley & Sons, Inc., New York (1999), Vol. 2, 728-742; Fix, J., "Oral drug delivery, small intestine and colon", Encyclopedia of Controlled Drug Delivery, Mathiowitz, E. (Ed.), John Wiley & Sons, Inc., New York (1999), Vol. 2, 698-728. The respective literature references are incorporated by reference and form part of the disclosure. The medicament of the present invention can also have at least one enteric coating, which dissolves according to the pH. As a result of this coating, the medicament can pass through the stomach without dissolving, and the compounds of general formula (I) are only released in the intestinal tract. The enteric coating preferably dissolves at a pH of between 5 and 7.5. The materials and methods suitable for preparing enteric coatings are also known in the prior art. Typically, the pharmaceutical compositions and the medicaments comprise from 1 to 60% by weight of one or more sulfonamide derivatives of general formula (J), and from 40 to 99% by weight of one or more excipients. The medicament substance amount to be administered to the patient varies according to the patient's weight, the administration route, the indication and the severity of the disorder. Usually from 1 mg to 2 g of at least one sulfonamide derivative of general formula (I) are administered per patient per day. The total daily dose can be administered to the patient in one or more doses. Pharmaceutical Methods: BINDING TO THE 5HT6 SEROTONIN RECEPTOR HEK-293 cell membranes expressing the recombinant human 5HT6 receptor were supplied by Receptor Biology. The receptor concentration in said membranes is 2.18 pmol/mg of protein and the protein concentration is 9.17 mg/ml. The experimental protocol follows the method of B.L. Roth et al. [B.L Roth, S.C. Craigo, M.S. Choudhary, A. Uluer, F.J. Monsma, Y. Shen, H.Y. Meltzer, D.R. Sibley: Binding of Typical and Atypical Antipsychotic Agents to 5-Hydroxytryptamine-6 and Hydroxytryptamine-7 Receptors. The Journal of Pharmacology and Experimental Therapeutics, 1994, 268,1403], with slight modifications. The commercial membrane is diluted (1:40 dilution) with the binding buffer: 50 mM Tris-HCI, 10 mM MgCI2, 0.5 mM EDTA (pH 7.4). The radioligand used is [3H]-LSD at a concentration of 2.7 nM, the final volume being 200 pi. Incubation begins by adding 100 nl of the membrane suspension (« 22.9 jag of membrane protein), and is prolonged for 60 minutes at a temperature of 37°C. Incubation ends by quick filtration in a Harvester Brandel Cell through fiberglass filters of the Scheleicher & Schuell GF 3362 trademark, pretreated with a 0.5% polyethyleneimine solution. The filters are washed three times with three milliliters of 50 mM Tris HCI buffer, pH 7.4. The filters are transferred to vials and 5 ml of Ecoscint H. liquid scintillation cocktail are added to each vial. The vials are left to equilibrate for several hours prior to their counting in a 1414 Wallac Winspectral scintillation counter. The non-specific binding is determined in the presence of 100 jaM of serotonin. The assays are\ carried out in triplicate. The inhibition constants (Ki, nM) are calculated by nonlinear regression analysis using the EBDA/LIGAND program [Munson and Rodbard, Analytical Biochemistry, 1980,107, 220]. MEASUREMENTS OF FOOD INGESTION (BEHAVIOR MODELS) Male W rats (200-270 g) from Marian, S.A. are used. The rats are acclimatized to the housings during at least 5 days prior to being subjected to any experiment. During this period, the animals are housed (in groups of five) in translucent cages with water and ad libitum food. The animals are adapted to individual housing at least 24 hours prior to the tests. The acute effect of the sulfonamide derivatives of general formula (I) used experimentally on food ingestion in rats in fasting conditions is determined as follows: The rats are kept in fasting conditions for 23 hours in their individual cages of origin. After this period, the rats are orally or intraperitoneally treated with a composition comprising a sulfonamide derivative of general formula (I) or a corresponding composition (vehicle) without said sulfonamide derivative. Immediately after this, the rat is left with pre-weighed food; the accumulated food intake is measured after 1, 2, 4 and 6 hours. Said food ingestion measuring method is also disclosed in the literature (Kask et al., European Journal of Pharmacology 414 (2001), 215-224, and Turnbull et al., Diabetes, Vol. 51, August, 2002). The respective parts of the descriptions are herein incorporated as a reference, and they form part of the disclosure. The preparation of new compounds according to the invention is indicated in the following examples. The affinity for the 5HTe serotonin receptor, as well as the galenic formulas applicable to the compounds of the invention, are described. The examples indicated below, given as an illustrative example, should in no way limit the scope of the invention. Examples: Example 1.- Preparation of 1-Cyclohexanesulfonyl-3-(1-methyl-1,2,3,6-tetrahydropyridine-4-yl)-5-nitro-1H-indoIe 468 mg (9.8 mMol) of 50% sodium hydride in oil were added at 0°C to a solution of 1.0 g (3.9 mMol) of 3-(1-methyl-1,2,3,6-tetrahydropyridine-4-yl)~5-nitro-1H-indole in 50 ml of anhydrous dimethylformamide, and the mixture was left to stir for 30 minutes. Then 2.14 g of cyclohexanesulfonyl chloride were added, and the stirring continued for 3 hours at room temperature. Water was added and evaporated to dryness. The resulting crude was treated with sodium bicarbonate and was extracted with chloroform. The organic phase was dried with anhydrous sodium sulfate and evaporated to dryness; the resulting solid was purified by chromatography, obtaining 900 mg (57%) of 1-cyclohexanesulfony!-3-(1 -methyl-1,2,3,6-tetrahydropyridine-4-yl)-5-nitro-1 H-indole as a yellow solid. Example 2.- 5-Chloro-1-cyclohexanesulfonyl-3-(1 -methyl-1,2,3,6-tetrahydropyridine-4-yl)-1H-indole 900 mg (74%) of the mentioned compound were obtained from 770 mg (3.12 mMol) of 5-chloro-3-(1-methyl-1 ^.S.e-tetrahydropyridine^-yl)-! H-indole, and 1.7 g (9.36 mMol) of cyclohexanesulfonyl chloride by means of the process described in Example 1, as a yellow solid. Example 3.- 5-Amino-1-cyclohexanesulfonyl-3-(1-methyl-1,2,3,6-tetrahydropyridine-4-yl)-1H-indole 200 mg of 50% Pd/C with a humidity of 5% were added to a solution of 403 mg (1 mMol) of 1-cyclohexanesulfonyl-3-(1-methyl-1,2,3,6-tetrahydropyridine-4-yl)-5-nitro-1H-indole in 200 ml of ethanol. The resulting suspension was hydrogenized at 25 psi of overpressure for 20 hours. Then the •catalyst was filtered and evaporated to drying. The resulting crude was purified by chromatography and 150 mg (40%) of the mentioned compound were obtained as a solid cream. Example 4.- Preparation of 1-Cyclohexanesulfonyl-5-fluoro-3-(1,2,3,5,8,83-hexahydro-indolizine-7-yl)-1H-indole 1.95 g (78%) of 1-cyclohexanesulfonyl-5-fluoro-3-(1,2,3,5,8,8a-hexahydro-indolizine-7-yl)-1H-indole were obtained as an oil from 1.6 g (6.25 mMol) of 5-fluoro-3-(1,2,3,5,8,8a-hexahydro-indolizine-7-yl)-1H-indole and 3.42 g (18.76 mMol) of cyclohexanesulfonyl chloride by means of the process described in Example 1. Then 2 ml of a 6N ethanol/HCI solution were added to a solution of 1.95 g (4.85 mMol) of 1 -cyclohexanesulfonyl-5-fluoro-3-(1,2,3,5,8,8a-hexahydro-indolizine-7-yl)-1H-indole in 20 ml of ethanol, precipitating a solid which was recrystallized from ethanol, obtaining 1.5 g (71%) of the mentioned compound as a white solid. The yields are indicative and no added effort was made to improve them. The melting point and spectroscopic data for identifying some of the compounds of the present invention are indicated in the following table. Pharmaceutical particulars: Binding of the new compounds of general formula (I) to the 5-HTe receptor was determined as previously described. The binding results for some of the compounds of the present invention are indicated in the following table: The daily posology in human medicine is comprised between 1 milligram and 2 grams of medicinal product which can be administered in one or several doses. The compositions are prepared under forms that are compatible with the administration route used, preferably tablets, coated tablets, capsules, suppositories, solutions or suspensions. These compositions are prepared by means of known methods and comprise from 1 to 60% by weight of the medicament substance (cornpound of general formula I), and 40 to 99% by weight of the suitable pharmaceutical vehicle compatible with the medicament substance and the physical form of the composition used. The formula of a tablet containing a product of the invention is provided by way of example: WE CLAIM: 1. Sulfonamide compounds of general formula (la), (Formula Removed) wherein R1 represents a -NR7R8 radical or a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as a ring member containing cycloaliphatic radical, which may be condensed with a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as a ring member containing mono-or bicyclic cycloaliphatic ring system, R2, R3, R4, R5 and R6, identical or different, each represent hydrogen, halogen, cyano, nitro, a saturated or unsaturated, linear or branched aliphatic radical, a linear or branched alkoxy radical, a linear or branched alkylthio radical, hydroxy, trifluoromethyl, a saturated or unsaturated cycloaliphatic radical, an alkylcarbonyl radical, a phenylcarbonyl or a - NR9R10 group, R7 and R8, identical or different, each represent hydrogen or a saturated or unsaturated, optionally at least mono-substituted linear or branched aliphatic radical, with the proviso that R8 and R9 are not hydrogen at the same time, and if one of them, R8 or R9, is a saturated or unsaturated, linear or branched, optionally at least mono-substituted C1-C4 aliphatic radical, the other one is a saturated or unsaturated, linear or branched, optionally at least mono-substituted aliphatic radical with at least five carbon atoms, or R7 and R8, together with the bridging nitrogen atom form a saturated or unsaturated, optionally at least mono-substituted, optionally at least one further heteroatom as a ring member containing heterocyclic ring which may be condensed with a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as a ring member containing mono-or bicyclic cycloaliphatic ring system, R9 and R10, identical or different, each represent hydrogen or a saturated or unsaturated, linear or branched, optionally at least mono-substituted aliphatic radical, or R9 and R10, together with the bridging nitrogen atom form a saturated or unsaturated, optionally at least mono-substituted, optionally at least one further heteroatom as a ring member containing heterocyclic ring which may be condensed with a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as a ring member containing mono-or bicyclic cycloaliphatic ring system, A and B, together with the carbon atom to which they are bonded, form a saturated or unsaturated, but not aromatic, optionally at least mono-substituted cycloalkyl ring, and n is 0, optionally in form of one of their stereoisomers, preferably enantiomers or diastereomers, their racemate or in form of a mixture of at least two of their stereoisomers, preferably enantiomers or diastereomers, in any mixing ratio, or a salt thereof, preferably a corresponding physiologically acceptable salt thereof or a corresponding solvate thereof. 2. The compounds as claimed in claim 1, wherein R1 represents a-NR7R8 radical or a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as a ring member containing 5-or 6-membered cycloaliphatic radical, which may be condensed with a saturated or unsaturated, optionally at least mono- substituted, optionally at least one heteroatom as a ring member containing mono-or bicyclic cycloaliphatic ring system, whereby the rings of the ring system are 5-or 6-membered, preferably a NR7R8 radical or a radical chosen from the group consisting of (Formula Removed) wherein, if present, the dotted line represents an optional chemical bond, and R19 represents hydrogen, a linear or branched C1-C6 alkyl radical or a benzyl radical, preferably hydrogen or a C1-C2 alkyl radical. 3. The compounds as claimed in claim 1 or 2, wherein R2, R3, R4, R5 and R6, identical or different, each represent hydrogen, F, Cl, Br, cyano, nitro, a linear or branched C16 alkyl radical, a linear or branched C2-6 alkenyl radical, a linear or branched C2-6 alkynyl radical, a linear or branched C16 alkoxy, a linear or branched C16 alkylthio, hydroxy, trifluoromethyl, a saturated or unsaturated C3-8 cycloaliphatic radical, a linear or branched C16 alkylcarbonyl radical, phenylcarbonyl or an -NR9R10 group, preferably H, F, CI, NO2, NH2 or a C12 alkyl radical. 4. The compounds as claimed in one or more of claims 1 to 3, wherein R7 and R8, identical or different, each represent hydrogen, a linear or branched, optionally at least mono-substituted C110 alkyl radical, a linear or branched, optionally at least mono-substituted, C2-10 alkenyl radical, or a linear or branched, optionally at least mono-substituted, C2-10 alkynyl radical or R7 and R8, together with the bridging nitrogen form a saturated or unsaturated, optionally at least mono-substituted, optionally at least one further heteroatom as a ring member containing 5-or 6-membered heterocyclic ring which may be condensed with a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as a ring member containing mono-or bicyclicc cycloaliphatic ring system, whereby the rings of the ring system are 5-6-or 7- membered. 5. The compounds as claim,ed in claim 4, wherein R7 and R8, identical or different, each represent hydrogen or a linear or branched C110 alkyl radical or R7 and R8, together with the bridging nitrogen atom form a radical chosen from the group consisting of (Formula Removed) wherein R20, if present, is hydrogen, a linear or branched C1-C6 alkyl radical or a benzyl radical, preferably hydrogen, or a C1-C2 alkyl radical. 6. The compounds as claimed in one or more of claims 1 to 5, wherein R9 and R10, identical or different, each represent hydrogen, a linear or branched, optionally at least mono-substituted C1-C10 alkyl radical, a linear or branched, optionally at least mono-substituted C2-C10 alkenyl radical or a linear or branched, optionally at least mono- substituted C2-C10 alkynyl radical or R9 and R10, together with the bridging nitrogen atom form a saturated or unsaturated, optionally at least mono-substituted, optionally at least one further heteroatom as a ring member containing 5-or 6-membered heterocyclic ring, which may be condensed with a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as a ring member containing mono-or bicyclic cycloaliphatic ring system whereby the rings of the ring system are 5-6-or 7- membered. 7. The compounds as claimed in claim 6, wherein R9 and R10, identical or different, each represent hydrogen or a linear or branched C1-C10 alkyl radical, or R9 and R10, together with the bridging nitrogen atom form a radical chosen from a group consisting of (Formula Removed) wherein R20, if present, is hydrogen, a linear or branched C1-C6 alkyl radical or a benzyl radical, preferably hydrogen, or a C1-C2 alkyl radical. 8. The compounds as claimed in one or more of claims 1-7, wherein A and B, identical or different, each represent a linear or branched C1-C6 alkyl radical, a linear or branched Ca-C6 alkenyl radical or a linear or branched Ca-C6 alkynyl radical, preferably a linear or branched C1-C6 alkyl radical, or A and B, together with the carbon atom to which they are bonded, form a saturated or unsaturated, but not aromatic, optionally at least mono-substituted cycloalkyl ring, preferably a C3-C8 cycloalkyl ring, more preferably a cyclohexyl ring. 9. The compounds as claimed in one or more of claims 1 to 8, wherein the compound is selected from a group consisting of [11 l-Cyclohexanesulfonyl-3- (1-methyl-l, 2,3, 6-tetrahydropyridine-4-yl)-5-nitro-1 H-indole, [21 5-Chloro-l-cyclohexanesulfonyl-3-( 1-methyl-l, 2,3, 6- tetrahydropyridine-4-yl)-l H-indole, [31 5-Amino-l-cyclohexanesulfonyl-3- (1-methyl-l, 2,3, 6- tetrahydropyridine-4-yl)-l H-indole and [41 l-Cyclohexanesulfonyl-5-fluoro-3- (1, 2,3, 5,8, 8a-hexahydro-indolizine- 7-yl)-l H-indole hydrochloride and their corresponding salts and solvates. 10. Sulfonamide compounds as claimed in claim 1 of general formula (lb), (Formula Removed) wherein R1 is a -NR7R8 radical R2, R3, R4, R5 and R6, identical or different, each represent hydrogen, halogen, cyano, nitro, a saturated or unsaturated, linear or branched aliphatic radical, a linear or branched alkoxy radical, a linear or branched alkylthio radical, hydroxy, trifluoromethyl, a saturated or unsaturated cycloaliphatic radical, an alkylcarbonyl radical, a phenylcarbonyl or a- NR9R10 group, R7 and R8, identical or different, each represent hydrogen or a saturated or unsaturated, optionally at least mono-substituted linear or branched C14 aliphatic radical, R9 and R10, identical or different, each represent hydrogen or a saturated or unsaturated, linear or branched, optionally at least mono-substituted aliphatic radical, or R9 and R10, together with the bridging nitrogen atom form a saturated or unsaturated, optionally at least mono-substituted, optionally at least one further heteroatom as a ring member containing heterocyclic ring which may be condensed with a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as a ring member containing mono-or bicyclic cycloaliphatic ring system, A and B, together with the carbon atom to which they are bonded, form a saturated or unsaturated, but not aromatic, optionally at least mono-substituted cycloalkyl ring, and n is 0 ; optionally in form of one of its stereoisomers, preferably enantiomers or diastereomers, their racemate or in form of a mixture of at least two of their stereoisomers, preferably enantiomers or diastereomers, in any mixing ratio, or a salt thereof, preferably a corresponding physiologically acceptable salt therof or a corresponding solvate thereof. 11. The compounds as claimed in claim 10, wherein R2, R3, R4, R5 and R6, identical or different, each represent hydrogen, F, Cl, Br, cyano, nitro, a linear or branched C1-C6 alkyl radical, a linear or branched C2-C6 alkenyl radical, a linear or branched C2-C6 alkynyl radical, a linear or branched C1-C6-alkoxy, a linear or branched C1-C6-alkylthio, hydroxy, trifluoromethyl, a saturated or unsaturated C3-C8 cycloaliphatic radical, a linear or branched C1-C6- alkylcarbonyl radical, phenylcarbonyl or an- NR9R10 group, preferably H, F, Cl, NO2, NH2 or a C1-C2 alkyl radical. 12. The compounds as claimed in claim 10 or 11, wherein R7 and R8, identical or different, wherein R7 and R8, identical or different, each represent hydrogen, a linear or branched, optionally at least mono- substituted C1-C4 alkyl radical, preferably hydrogen or a C1-C2 alkyl radical, with the proviso that R7 and R8 are not hydrogen at the same time. 13. The compounds as claimed in one or more of claims 10 to 12, wherein R9 and R10, identical or different, each represent hydrogen, a linear or branched, optionally at least mono-substituted C1-C10 alkyl radical, a linear or branched, optionally at least mono- substituted C2-C10 alkenyl radical, or a linear or branched, optionally at least mono-substituted C2-C10 alkynyl radical or R9 and R10, together with the bridging nitrogen atom form a saturated or unsaturated, optionally at least mono-substituted, optionally at least one further heteroatom as a ring member containing 5-or 6-membered heterocyclic which may be condensed with a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as a ring member containing mono-or bicyclicc cycloaliphatic ring system, whereby the rings of the ring system are 5-6-or 7-membered. 14. The compounds as claimed in claim 13, wherein R9 and R10, identical or different, each represent hydrogen or a linear or branched C1-C10 alkyl radical, or R9 and R10, together with the bridging nitrogen atom form a radical chosen from a group consisting of (Formula Removed) wherein R20, if present, represents hydrogen, a linear or branched C1-C6 alkyl radical or a benzyl radical, preferably hydrogen, or a C1-C2 alkyl radical. 15. The compounds as claimed in claim 1, wherein A and B, together with the carbon atom to which they are bonded, form a saturated or unsaturated, but not aromatic, optionally at least mono-substituted cycloalkyl ring, preferably a C3-C8 cycloalkyl ring, more preferably a cyclohexyl ring. 16. A process for obtaining a sulfonamide derivative of general formula (la) and/or (lb), as claimed in claim 1, wherein at least one compound of general formula (II), or one of its suitably protected derivatives, (Formula Removed) wherein A and B have the meaning as claimed in one or more of claims 1 to 15 and X is an acceptable leaving group, preferably an halogen atom, more preferably chlorine, is reacted with at least one substituted indole of general formula (III) (Formula Removed) wherein R1-R6 and n have the meaning according to one or more of claims 1 to 15, or one of their suitable protected derivatives, and, if necessary, the protective groups are removed. 17. A medicament comprising at least one compound as claimed in one or more of claims 1 to 9 and optionally one or more pharmacologically acceptable excipients. 18. The compound as claimed in claims 1 to 9 wherein said compound is useful as a 5-HT6 receptor regulation agent.

Documents:

184-DELNP-2006-Abstract-15-01-2009.pdf

184-delnp-2006-abstract.pdf

184-DELNP-2006-Claims-(24-12-2008).pdf

184-DELNP-2006-Claims-15-01-2009.pdf

184-delnp-2006-claims.pdf

184-delnp-2006-complete specification (granted).pdf

184-delnp-2006-correspondence-others 1.pdf

184-DELNP-2006-Correspondence-Others-(24-12-2008).pdf

184-delnp-2006-correspondence-others.pdf

184-delnp-2006-description (complete)-15-01-2009.pdf

184-delnp-2006-description (complete).pdf

184-DELNP-2006-Form-1-(24-12-2008).pdf

184-delnp-2006-form-1.pdf

184-delnp-2006-form-18.pdf

184-DELNP-2006-Form-2-(24-12-2008).pdf

184-delnp-2006-form-2.pdf

184-DELNP-2006-Form-3-(24-12-2008).pdf

184-delnp-2006-form-3.pdf

184-delnp-2006-form-5.pdf

184-DELNP-2006-GPA-(24-12-2008).pdf

184-delnp-2006-gpa.pdf

184-delnp-2006-pct-210.pdf

184-delnp-2006-pct-304.pdf

184-delnp-2006-pct-409.pdf

184-delnp-2006-pct-416.pdf

184-DELNP-2006-Petition-137-(24-12-2008).pdf

184-DELNP-2006-Petition-138-(24-12-2008).pdf