Title of Invention

ORAL DRUG DELIVERY SYSTEM

Abstract

An oral drug delivery system comprising a coated tablet having one or more surfaces, the coated tablet further comprising: a core comprising an active ingredient composition comprising at least one active ingredient and a pharmaceutically acceptable excipient and a composition selected from a swellable composition and a reactive composition located in an immediate vicinity of one or more preselected surfaces, and a coating surrounding the core, wherein the coating is selected from a group consisting of defective coatings and reactive coatings, wherein the coating is operable to be reliably removed fully from the one or more of the preselected surfaces of the tablet upon contact with an aqueous environment, but not removed from at least one of the surfaces.

Full Text

FORM 2 THE PATENTS ACT. 1970 (39 OF 1970) k THE PATENT RULES. 2003 (See section 10 and rule 13) COMPLETE SPECIFICATION ORAL DRUG DELIVERY SYSTEM SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED A company incorporated under the laws of India having their office at 17/B, MAHAL INDUSTRIAL ESTATE. OFF MAHAKALI CAVES ROAD, ANDHERl (E), MUMBAI-400093. MAHARASHTRA, INDIA. The following specification particularly describes and ascertains the nature of this invention and the manner in which it is to be performed. The present invention relates to an oral drug delivery system comprising a coating that is reliably removed fully or partially from one or more preselected surfaces of the system upon contact of the system with an aqueous environment. BACKGROUND OF THE INVENTION Oral administration of a drug provides a plasma level time profile of a drug or its active or inactive metabolite, which can be modulated by the design of the drug delivery system or dosage form. Drug delivery system or dosage forms have been designed in various ways, depending on the requirements of the therapy or the needs of the patient. For example, the formulations may be designed to include a coating for the purpose of protecting the drug from the environment or prevent the release in the oral cavity and interaction of the drug with taste buds and yet release the drug instantly and rapidly in the stomach by dissolution of the coating in the gastric fluid. Instant and rapid release of the drug enables quick onset of action. These systems depend on pH-dependent coatings, which will not dissolve in the salivary fluids but dissolve readily in the gastric fluids. However, systems that depend on pH-independent coatings but can perform the same function are not available. Drug delivery systems releasing the drug slowly over longer duration have been traditionally used to improve therapy by • improving patient compliance to dosage regimens through the decrease in the number of doses the patient has to take in a day, by providing desired effective plasma levels for therapeutic efficacy over the duration of therapy for example throughout the day including at night when the patient is asleep; • decreasing peak plasma levels when they are associated with side effects; • reducing side effects in chronic therapy by reducing the fluctuation in plasma levels seen after multiple dosing of conventional rapid release systems; • when the drug has local action on the gastrointestinal mucosa, to spread the release spatially over the whole of the gastrointestinal mucosa as the drug delivery system is transported in the mucosa by the motility of the gastrointestinal tract. Drug delivery systems are also designed to release the drug at specific site in the gastrointestinal tract by use of pH-dependcnt coatings that dissolve in the pH environment at the specific gastrointestinal site. There is a need for designing cores for such coated systems wherein the cores provide rapid release without substantial delay over the specific site or region, for example a release initiated over a period of 1 minute to 30 minutes after encountering the particular site or pH. There is also a need for designing cores for such site-specific coated systems wherein the cores are designed to provide controlled release over the specific region, for example from the colon to the rectum. We have designed novel core coated oral drug delivery systems that utilize novel technology for reliably removing the coating fully or partially from one or more preselected surfaces of the system upon contact with an aqueous environment. This novel technology can be gainfully employed in any of the above-described drug delivery systems to meet specific objectives of therapy. United States Patent number 4,839,177 (the '177 patent) discloses a system for controlled-rate release of active substances consisting of (a) a deposit core of a defined geometric form, comprising a polymeric material having a high degree of swelling and a gellable polymeric material, and (b) a support platform consisting of a polymeric material insoluble in aqueous fluids applied to the deposit core such that it partially coats the deposit core. The trademark, Geomatrix®, refers to this system. The disadvantage of this system is that the rigid support platform can crack or flake before the active substance is completely released. United States Patent number 5,422,123 is an improvement over the '177 patent in that the support platform consists of polymer substances, which are slowly soluble and/or gellable in aqueous fluids, and plasticisers, such that the support platform does not crack or flake before the drug is completely released from the deposit core. Although the patents disclose systems wherein surface area of release is reduced by covering two or more surfaces of the deposit cere, in practice such systems are difficult to manufacture at an industrial scale - especially systems wherein two lateral surfaces and one planar surface are coated by the support platform. For example, in example 2 of the '177 patent, the barrier layers were applied by immersing the core in a polymeric solution as far as the edge of its upper base, such that two lateral sides and one planar surface of the core are coated. In example 3 of the ' 177 patent, the barrier layers were coated on the lateral sides of the core by spraying or brushing the polymeric solution onto the sides. These methods, although possible on small experimental scale, are not feasible and reproducible on an industrial scale. United States Patent number 5,650,169 provides a pharmaceutical tablet capable of releasing the active ingredients contained therein at subsequent times, the tablet being prepared by a process wherein a three-layered tablet core comprising a first drug-containing layer, an intermediate barrier layer and a third drug-containing layer are covered with an impermeable polymeric film. The first layer presents a raised top, which is removed by abrasion so as to allow contact of the abraded first layer surface with the environment. The composition of the barrier layer is designed to modulate release from the third layer of the tablet. A major disadvantage of this system is that it requires removal of the raised top layer by abrasion to provide a means for release of the components of the system. This may not be feasible at an industrial scale. Further, if the abrasion is not uniform, the release of the active ingredients will be affected. j\//. United States patents 6,720,005 and 6,733,784 relate to coated, platform-generating tablets. The tablet hydrates and expands upon swallowing such that the membrane' covering the coating .C ^r ruptures mostly around the belly-band surface of the tablet due to swelling of the core, thereby exposing the belly surface of the core tablet to hydrating and eroding liquids. A disadvantage of the system is that the coating is not reliably removed from the belly-band surface always but may rupture at a different weak point. Thus, the surface area of exposure may vary. Also, the systems 1 show a lag time of release of half an hour or more. Many shapes of the core have been suggested in the invention but some of these may accentuate the problems encountered during tablet manufacture. Also, the belly-band surface, which is exposed after the coating ruptures, has the least surface area and other more preferred surfaces are not exposed. OBJECT OF THE INVENTION It is an object of the present invention to design a coated oral drug delivery system in a manner such that the coating is reliably removed fully or partially from one or more preselected surfaces of the system upon contact of the system with an aqueous environment, provided further that the coating is not removed from at least one of the surfaces. \ It is an object of the present invention to provide the afore-said oral drug delivery system, which \\ is designed to provide controlled release of the active ingredient contained therein. It is another object of the present invention to provide an oral drug delivery system that provides zero-order controlled release while achieving the aforesaid objectives. It is another object of the present invention to provide an oral drug delivery system to protect the active ingredient contained therein with a coating, and wherein the coating is ruptured upon contact with surrounding aqueous environment, permitting the instant and rapid release of the active ingredient. It is a further object of the present invention to provide an oral drug delivery system that achieves the aforesaid objectives at a defined pH. It is yet another objective of the present invention to provide an oral drug delivery system, which is easy to manufacture. SUMMARY OF THE INVENTION The present invention provides coated oral drug delivery systems using novel technology for removing coatings upon contact with an aqueous environment Various embodiments are summarized below. (i) An embodiment of the present invention provides an oral drug delivery system comprising- a. a core comprising an active ingredient composition comprising at least one active ingredient and a pharmaceutically acceptable excipient, and b. a coating surrounding the core, wherein the drug delivery system is designed in a manner such that the coating is reliably removed fully or partially from one or more preselected surfaces of the system upon contact with an aqueous environment, provided further that the coating is not removed from at least one of the surfaces, (ii) An embodiment of the present invention provides an oral drug delivery system comprising- a. a core comprising an active ingredient composition comprising at least one active ingredient and a pharmaceutically acceptable excipient, and b. a coating surrounding the core, wherein the oral drug delivery system is in the form of a coated tablet and includes a feature such that the coating is removed partially or fully from one or more of the tablet surfaces upon contact with an aqueous environment, further wherein the feature is such that it enables the selection of any of the tablet surface or surfaces from which the coating is desired to be partially or fully removed, provided further that the coating is not removed from at least one of the surfaces, (iii) An embodiment of the present invention as described in (ii) above wherein the feature is included in the coating or the core or both, (iv) An embodiment of the present invention as described in (iii) above wherein the feature is that the coating on selected surface or surfaces of the tablet is selected from defective coatings and reactive coatings, (v) An embodiment of the present invention as described in (iii) above wherein the feature is that the coating on selected surface or surfaces of the tablet includes one or more passageways in the coating on the selected surfaces, (vi) An embodiment of the present invention as described in (iii) above wherein the feature is that the core comprises a composition selected from a swellable composition and a reactive core composition, (vii) An embodiment of the present invention as described in (vi) above wherein the feature is located in the immediate vicinity of one or more selected surfaces of the tablet, (viii) An embodiment of the present invention as described in (v) above, wherein the coating is impermeable to the active ingredient, (ix) An embodiment of the present invention as described in (i) above, wherein the active ingredient composition is a swellable composition, (x) An embodiment of the present invention as described in (i) above, wherein the core comprises an active ingredient composition and a swellable composition, (xi) An embodiment of the present invention as described in (x) above, wherein the active ingredient composition is present as one or more layers and the swellable composition is present as one or more layers, (xii) An embodiment of the present invention as described in (xi) above, wherein the active ingredient present in the different layers may be the same or different, (xiii) An embodiment of the present invention as described in (i) above, wherein the active ingredient composition is a controlled release composition, (xiv) An embodiment of the present invention as described in (xi) above, wherein one active ingredient composition is a rapid releasing composition and the second active ingredient composition containing the same active ingredient as the first active ingredient composition is a controlled release composition, (xv) An embodiment of the present invention as described in (x) above, wherein the swellable composition comprises a swelling agent. 6 (xvi) An embodiment of the present invention as described in (xv) above, wherein the swelling agent is selected from the group comprising a swellable excipient, a gas generating agent and mixtures thereof, (xvii) An embodiment of the present invention as described in (x) above, wherein the swellable composition comprises wicking agents, (xviii) An embodiment of the present invention as described in (x) above, wherein the swellable composition comprises osmogents. (xix) An embodiment of the present invention provides an oral controlled drug delivery system comprising - a. a core comprising an active ingredient composition comprising at least one active ingredient and pharmaceutically acceptable excipients, b. a coating surrounding the core, and c. a passageway in the coating, wherein the oral drug delivery system is designed in a manner such that the coating is removed partially upon contact of the system with an aqueous environment allowing the active ingredient release to occur from the partially exposed surface, (xx) An embodiment of the present invention provides an oral drug delivery system comprising - a. a core comprising an active ingredient composition comprising at least one active ingredient and pharmaceutically acceptable excipients, and b. a coating surrounding the core, wherein the oral drug delivery system has only one Surface and the system is designed in a manner such that the coating is removed partially from the surface upon contact of the system with an aqueous environment, (xxi) An embodiment of the present invention provides an oral drug delivery system i comprising - a. a core comprising an active ingredient composition comprising at least one active ingredient and pharmaceutically acceptable excipients, and b. a coating surrounding the core wherein the oral drug delivery system has at least two surfaces and is designed in a manner such that the coating is removed partially from one of the surfaces when the oral drug delivery system contacts an aqueous environment, and further wherein the coating is removed from the surface different from the one having the least surface area. (xxii) An embodiment of the present invention as described in (i) above wherein the drug release is initiated without a substantial delay after the oral drug delivery system contacts an aqueous environment, (xxiii) An embodiment of the present invention as described in (i) above further comprising an outer coating of a pH-dependent polymer, (xxiv) An embodiment of the present invention provides a method of isolating an active ingredient from its environment by providing an oral drug delivery system comprising - a. a core comprising an active ingredient composition comprising at least one active ingredient and pharmaceutically acceptable excipients, and b. a coating surrounding the core wherein the system has a feature such that upon contact with an aqueous environment the coating ruptures to provide instant and rapid release of the active ingredient. BRIEF DESCRIPTION OF THE FIGURES Figure 1 is a diagrammatic representation of an embodiment of the oral drug delivery system of the present invention wherein the coating has a passageway. Figure 1(a) is a diagrammatic representation of an embodiment of the oral drug delivery system of the present invention comprising a core (1) comprising an active ingredient composition, which is surrounded by a coating (2) having a passageway (3) therein. Figure 1(b) is a diagrammatic representation of the present invention comprising a core comprising an active ingredient composition (4) and a swellable composition (5), the core being surrounded by a coating (2) having a passageway (3) therein. Figure 1(c) is a diagrammatic representation of the present invention comprising a core comprising an active ingredient composition (4) and two swellable compositions (5) on either side of the active ingredient composition, so as to form a trilayered core, the core being surrounded by a coating (2) having a passageway (3) therein. The swellable compositions may or may not comprise an active ingredient. Figure 2 is a diagrammatic representation of an embodiment of the present invention wherein the coating does not have a passageway. Figure 2(a) is a diagrammatic representation of one embodiment of the present invention comprising a core comprising an active ingredient composition (1) surrounded by a coating (2). Figure 2(b) is a diagrammatic representation of one embodiment of the present invention comprising a core comprising an active ingredient composition (4) and a swellable composition (5), the core being surrounded by a coating (2). Figure 2(c) is a diagrammatic representation of one embodiment of the present invention comprising a core comprising an active ingredient composition (4) and two swellable compositions (S) on either side of the active ingredient composition, so as to form a trilayered core, the core being surrounded by a coating (2). The swellable compositions may or may not comprise an active ingredient. Further embodiments of the oral drug delivery systems of the present invention are not all illustrated herein. For example, further embodiments wherein any of the systems illustrated in Figures 1 and 2 may be further surrounded by an outer coating of a pH-dependent polymer, are not represented herein. Figure 3 is a graph showing percent drug (metoprolol) released versus time from formulations of Formulae I, II, HI and IV of Example 1. Figure 4 is a graph showing percent drug (bupropion) released versus time from formulation of Example 2. Figure 5 is a graph showing percent drug (oxybutynin) released versus time from formulations of Examples 3 and 4. * Any of the embodiments illustrated herein ■are provided for the purpose of illustration only and are by no means meant to narrow the scope of the present invention. DETAILED DESCRIPTION OF THE INVENTION The present invention provides an oral drug delivery system comprising - a. a core comprising an active ingredient composition comprising at least one active ingredient and a pharmaceutically acceptable excipient, and b. a coating surrounding the core, wherein the drug delivery system is designed in a manner such that the coating is reliably removed fully or partially from one or more preselected surfaces of the system upon contact with an aqueous environment, provided further that the coating is not removed from at least one of the surfaces. Accordingly, the coating is partially removed from the system but may be fully or partially removed from one or more preselected surfaces. Hereafter, unless it is specified that the coating is removed from a surface the use of the term 'partial removal of coating' will refer to partial removal from the system. The term "reliably" as used herein means that the coating is removed from the preselected surfaces and does not rupture from any other non-selected weak point in the coating. In contrast, prior art system disclosed in US 6,720,005 and US 6,733,784 rupture "mostly" around the belly-band area. More particularly, the present invention provides an oral drug delivery system comprising - (a) a core comprising an active ingredient composition comprising at least one active ingredient and a pharmaceutically acceptable excipient, and (b) a coating surrounding the core, wherein the oral drug delivery system is in the form of a coated tablet and includes a feature such that the coating is removed partially or fully from one or more of the tablet surfaces upon contact with an aqueous environment, further wherein the feature is such that it enables the selection of any of the tablet surface or surfaces from which the coating is desired to be partially or fully removed, provided further that the coating is not removed from at least one of the surfaces. The oral drug delivery system of the present invention is designed such that the coating is removed fully or partially from a preselected surface or surfaces upon contact with an aqueous environment and not removed from at least one of the surfaces. The partial removal of the coating may be affected by several means and the features enabling the same may be features of the coating or the core, or both, operating cooperatively. For example, the system may be designed such that the coating is soluble or dissolved from one surface of the system, but not dissolved from the other surfaces of the system, thus becoming partially removed from the system. Alternatively, the oral drug delivery system may be designed such that the coating is ruptured and removed fully or partially from one or more preselected surfaces of the system upon contact with an aqueous environment. As used herein the term "defective coating" refers to coatings that are susceptible to rupture due to a weakness. The defective coating on the preselected surface may be made by creating a weakness in the coating by mechanical, chemical or electrical means, or by radiation, or by designing a brittle coating, or a thin coating, or a brittle and thin coating or a porous coating on the preselected surface or surfaces. The defect may also be instantly created on the preselected surface by leaching of components of the coating upon contact with the aqueous environment. The defect may be in the form of an apparent fault such as an indent or a tear or a cut or an etching, which beginning from the outer surface of the coating may penetrate only partially through the coating or may penetrate completely to the inner surface of the coating so as to form a passageway. The core may be designed with a swellable or a reactive composition in the vicinity of the preselected surface. In preferred embodiments of the present invention, the core is swellable, and the coating is impermeable to the active ingredient and has a passageway therein. Upon contact with an aqueous environment, water permeates through the passageway, the core swells and the coating ruptures from the selected surface or surfaces that have one or more passageways. The reactive composition is reactive with the coating in that in the presence of ingredients released from the reactive composition, the coat in the vicinity dissolves, disintegrates or is weakened. The coating surrounding the core of the oral drug delivery system of the present invention is preferably impermeable to the active ingredient, and has a passageway therein. In one preferred embodiment of the coating with a passageway, the coating is made up of water-insoluble polymers that may be selected from ethyl cellulose, hydrophobic methacrylic acid derivatives and the like, and mixtures thereof. Preselected one or more surfaces of the coating are then provided with a mechanically or laser-drilled passageway, and cause the core to partially remove the coating, thereby exposing a portion of the core for the release of the active ingredient contained therein. In more preferred embodiments of the present invention wherein the coating has a passageway, the oral drug delivery system is in the form of a tablet The passageways in the coating may be provided on one or more preselected surfaces of the tablet, such that when water from the surrounding environment enters the tablet through the passageway, the core causes partial removal of the coating from the preselected surfaces, thereby exposing a defined surface area for release of the active ingredient. In preferred embodiments the core has components that are swellable or reactive to the coating. Embodiments of the present invention provide an oral drug delivery system comprising - a. a core comprising an active ingredient composition comprising at least one active ingredient and pharmaceutically acceptable excipients, and b. a coating surrounding the core, wherein the oral drug delivery system has at least two surfaces and is designed in a manner such that the coating is removed fully or partially from one of the surfaces when the oral drug delivery system contacts an aqueous environment and further wherein the coating is removed from the surface different from the one having the.least surface area. The oral drug delivery systems of the present invention provide benefit over prior art systems which do not provide a flexibility in choice of the surface from which the coating can be removed, and generally expose the surface with the lower surface area. Specific embodiments of the present invention also provide aforesaid ora) drug delivery system, which release the drug without a substantial delay after the oral drug delivery system contacts an aqueous environment. The term "without a substantial delay" as used herein means that the active ingredient release is initiated from the controlled drug delivery system of the present invention within 0 to 60 minutes from the time the core contacts an aqueous environment, preferably within 0 to 20 minutes, and most preferably within 0 to 5 minutes. In one embodiment of the present invention, the active ingredient composition is a swellable composition comprising at least one active ingredient and a swelling agent. In another embodiment of the present invention, the core comprises active ingredient composition and swellable composition, which may b^ present as one or more layers. The active ingredient present in these layers may be the same or different. In one embodiment of the present invention the active ingredient is isolated from its environment by providing an oral drug delivery system comprising - a. a core comprising the active ingredient and pharmaceutically acceptable excipients, and b. a coating surrounding the cote, wherein the system has a feature such that upon contact with an aqueous environment the coating ruptures to provide instant and rapid release of the active ingredient. Such systems are useful for active ingredients that are bitter in taste, or active ingredients that irritate the mucosal surface. Also, the system is useful for active ingredients that need to be protected from being degraded by contact with fluids from the surrounding environment. The partial removal of the coating m&y also be affected by including a composition comprising gas generating agents in the core, such that when the coating contacts an aqueous environment, tire gas generating agents refcase gas, generating pressure that causes tfie coating to be removed 12 partially. Preferably, the swellable composition may comprise a mixture of swellable excipients and gas generating agents, the mixture being designed with types and amounts of components selected so as to cause the removal of the coating and initiation of release without a substantial delay or to cause a predetermined period of delay. The swellable composition used in oral drug delivery system of the present invention comprises a swellable agent that may be selected from a group comprising a swellable excipient, a gas generating agent and mixtures thereof. The swelling agent is generally used in an amount ranging from about 0.5% to about 95% by weight of the swellable composition. The swellable excipient that may be used may be a highly swellable excipient selected from vinylpyrrolidone polymers such as crospovidone; cellulose and cellulose derivatives such as carboxyalkyl celluloses, crosslinked carboxyalkylcelluloses and their alkali salts; sodium starch glycolate, starch and starch derivatives, resins and mixtures thereof. The highly swellable excipient is preferably used in an amount ranging from about 2% to about 35% by weight of the swellable composition. The swellable excipient that may be used may be a moderately swellable excipient and may be used in an amount ranging from about 5% to about 70% by weight of the swellable composition, preferably about 50% to about 70% by weight of the swellable composition. Gas generating agents that may be used in the present invention include carbonates such as calcium carbonate, bicarbonates such as sodium or potassium bicarbonate, sulfites such as sodium sulfite, sodium bisulfite, or sodium metabisulfite, and the like. These salts may be used alone or in combination with an acid source as a gas generating couple. The acid source may be an edible organic acid, a salt of an edible organic acid, acidic components such as acrylate polymers, or mixtures thereof. Examples of organic acids that may be used include citric acid, malic acid, succinic acid, tartaric acid, fumaric acid, maleic acid, ascorbic acid, glutamic acid, and their salts, and mixtures thereof. The swellable composition may further comprise a wicking agent in an amount ranging from about 0.5% to about 10% by weight of the swellable composition. Examples of wicking agents that may be used include, but are not limited to, colloidal silicon dioxide, kaolin, titanium dioxide, fumed silicon dioxide, alumina, niacinamide, sodium lauryl sulfate, low molecular weight polyvinylpyrrolidone, m-pyrol, bentonite, magnesium aluminum silicate, polyester, polyethylene. Preferably, the wicking agents used in the pharmaceutical composition of the present invention include cellulose and cellulose derivatives, colloidal silicon dioxide,.and mixtures thereof. The sweUable composition may also comprise osmogents in an amount ranging from about 0.5% to about 10% by weight of the sweUable composition. Examples of osmogents that may be used include, but are not limited to, inorganic salts such as magnesium chloride or magnesium sulfate, lithium, sodium or potassium chloride, lithium, sodium or potassium hydrogen phosphate, lithium, sodium or potassium dihydrogen phosphate, salts of organic acids such as sodium or potassium acetate, magnesium succinate, sodium benzoate, sodium citrate or sodium ascorbate; carbohydrates such as mannitol, sorbitol, arabinose, ribose, xylose, glucose, fructose, mannose, galactose, sucrose, maltose, lactose, rafftnose; water-soluble amino acids such as glycine, leucine, alanine, or methionine; urea and the like; osmopolymers selected from the group consisting of poly(hydroxyalkyl methacrylate) having a molecular weight of 20,000 to 5,000,000; poly (vinylpyrrolidone) having a molecular weight of about 10,000 to 360,000; poly(vinyl alcohol) having a low acetate content and lightly crosslinked with glyoxal, formaldehyde, glutaraldehyde and having a degree of polymerization from 2,000 to 30,000; poly(ethylene oxide) having a molecular weight from 10,000 to 7,8000,000; acidic carboxy polymers known as carboxypolymethylene or as carboxyvinyl polymers, a polymer consisting of acrylic acid lightly cross-linked with polyallylsucrose and sold under the trademark Carbopol*, acidic carboxy polymer having a molecular weight of 200,000 to 6,000,000, including sodium acidic carboxyvinyl hydrogel and potassium acidic carboxyvinyl hydrogel; Cyanamer® polyacrylamide; and the like, and mixtures thereof. In one embodiment of the present invention, the coating surrounding the core is semipermeable in nature and may be obtained by using water-insoluble agents like cellulose derivatives such as cellulose acetate, ethyl cellulose and the like, in admixture with a sufficient amount of one or more water-soluble polymers selected from methyl cellulose, hydroxypropyl methylcellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, polyvinylpyrrolidone and mixtures thereof, such that the properties of the semipermeable coating are modified, thereby allowing the coating to be removed partially upon contact with an aqueous environment. The coating does not have any passageway therein. The coating being semipermeable in nature allows water from the surrounding environment to enter the system, thereby causing the core to remove the coating partially so as to expose a defined surface area for release of the active ingredient. In a preferred embodiment of the present invention, a mixture of a water-soluble polymer and a water-insoluble polymer is used to obtain the coating. For example, a mixture of ethyl cellulose and hydroxypropyl methylcellulose, or a mixture of ethyl cellulose and polyvinylpyrrolidone, may be used to obtain the coating. In embodiments where the coating does not have a passageway, the oral drug delivery system may be coated to a weight gain in the range of about 2% to about 6.5% by weight of the core, such that the active ingredient is released without a substantial delay or may be coated to higher percentage for designing a programmed delay of release into the system. When release without a substantial delay is desired it is preferable that the coating have a passageway. In these embodiments, the release without a substantial delay is obtained more easily and a wide range of cgating weights may be used. In one embodiment of the present invention, the core comprises an active ingredient composition comprising at least one active ingredient and pharmaceutically acceptable excipients. In another embodiment -of the present invention, the active ingredient composition is a swellable composition comprising at least one active ingredient, and a swelling agent. In yet another embodiment of the present invention, the core comprises an active ingredient composition and swellable composition, which may both be present as one or more layers. The active ingredient present in these layers may be the same or different. Each of these embodiments comprises a coating surrounding the core, which is semipermeable in nature, and does not have any passageway. The oral drug delivery system of the present invention maybe designed to release the active ingredient contained therein in a controlled manner, or it may be designed to provide instant and rapid release of the active ingredient similar to uncoated conventional dosage forms while providing the desirable protection of the coating. Accordingly, the core of the oral drug delivery system comprises pharmaceutically acceptable excipients that govern the rate of release of the active ingredient from the core. The pharmaceutical excipients are selected so as to provide a conventional release, or controlled release, preferably zero-order release of the active ingredient. In one embodiment of the present invention, the oraJl drug delivery system is designed to release the active ingredient in a controlled manner. The active ingredient composition therefore comprises rate controlling excipients that may be selected from hydrophilic polymers such as methyl cellulose, hydroxypropyl methylcellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxyethyl methylcellulose, carboxymethylcellulose and sodium carboxymethylcellulose; hydrophobic compounds such as ethyl cellulose, glycerol palmitostearate, beeswax, glycowax, castor wax, carnauba wax, glycerol monostearate, stearyl alcohol, glycerol behenic acid ester, cetyl alcohol, natural and synthetic glycerides, waxes, fatty acids, hydrophobic polyacrylamide derivatives, hydrophobic methacrylic acid derivatives; vinyl pyrrolidone polymers such as polyvinylpyrrolidone and copolymers of vinyl pyrrolidone and vinyl acetate; alkylene oxide homopolymers; gums of plant, animal, mineral or synthetic origin; and mixtures thereof. The active ingredient composition may comprise one or more of the rate controlling excipients mentioned above in an amount ranging from about 2% to about 90% by weight of the core; the specific amounts and type may be selected to either not cause a substantial delay in the initiation of release or to provide a programmed delay in the initiation of release. The active ingredient composition used in the core of the controlled drug delivery system of the present invention comprises one or more active ingredient, rate controlling excipients and other pharmaceutically acceptable excipients. Drugs that may be used in the pharmaceutical composition of the present invention may be selected from the following, viz. alcohol abuse preparations, drugs used for Alzheimer's disease, anesthetics, acromegaly agents, analgesics, antiasthmatics, anticancer agents, anticoagulants and antithrombotic agents, anticonvulsants, antidiabetics antiemetics, antiglaucoma, antihistamines, anti-infective agents, antiparkinsons, antiplatelet agents, antirheumatic agents, antispasmodics and anticholinergic agents, antitussives, carbonic anhydrase inhibitors, cardiovascular agents, cholinesterase inhibitors, treatment of CNS disorders, CNS stimulants, contraceptives, cystic fibrosis management, dopamine receptor agonists, endometriosis management, erectile dysfunction therapy, fertility agents, gastrointestinal agents, immunomodulators and immunosuppressives, memory enhancers, migraine preparations, muscle relaxants, nucleoside analogues, osteoporosis management, parasympathomimetics, prostaglandins, psychotherapeutic agents, sedatives, hypnotics and tranquilizers, drugs used for skin ailments, steroids and hormones. In one embodiment of the present invention, the core comprises - a. a first layer of active ingredient composition b. a second layer ofactive ingredient composition, and c. a third layer of a swellable composition, wherein the active ingredient compositions of the first and second layer may comprise active ingredients that are same or different, and the swellable composition comprises a swelling agent, and may or may not comprise an active ingredient. In one embodiment of the present invention, the swellable composition is present as an in-lay tablet in a core comprising the active ingredient composition. The core with the in-lay tablet is coated with an impermeable coating having a passageway on the surface immediately above the swellable composition. The swellable composition ruptures the coat upon contact with aqueous environment, thereby exposing a defined surface area. The active ingredient is then released from the exposed surface. In another embodiment of the present invention, the core is compressed into a bilayer tablet; the first layer comprising the active ingredient composition having uninterrupted plain surfaces surrounded by coating or the second layer; and the second layer comprising the swellable composition having at least one surface interrupted by at least one depression or cavity. The coating used in this embodiment is semipermeable in nature and the water entering the system causes the coating to be removed from the surface having the depression or cavity. In some embodiments of the present invention, any of the aforesaid oral drug delivery systems may be further coated with an outer pH-dependent coating that partially or completely covers the inner coating, which immediately surrounds the core. An intermediate seal coating may be provided between the inner coating and the outer pH-dependent coating. pH-dependent polymers commonly used in the art may be used to provide the outer coating. The examples that follow do not limit the scope of the invention and are merely used as illustrations. Example 1 Oral drug delivery systems comprising metoprolol succinate were obtained as per the present invention, as detailed in Table 1 below. Table 1 Ingredients Quantity mg/tablet) I II III IV First layer Metoprolol succinate 35.625 47.5 47.5 47.5 Hydroxypropyl methylcellulose (HPMC K15M) 15.0 20.0 - - Hydroxypropyl methylcellulose (HPMC K100M) - - 20.0 - Polyvinylpyrrolidone (PVP K30) 7.5 10.0 10.0 10.4 Lactitol monohydrate 15.0 20.0 20.0 - Microcrystalline cellulose - - - 44.5 Hydroxypropyl methylcellulose (HPMC . E50LV) - - - 10.0 Sodium starch glycolate 15.0 20.0 20.0 - Colloidal silicon dioxide 0.375 0.5 0.5 1.2 Talc 1.125 1.5 1.5 1.7 Magnesium stearate 1.125 1.5 1.5 1.7 Aquacoat ECD 30 (solids) - -• - 18.0 Second layer Metoprolol succinate 11.875 - - - Silicified microcrystalline cellulose (Prosolv SMCC90) 20.0 34.32 34.32 34.32 Crospovidone - 12.18 12.18 12.18 Colloidal silicon dioxide 0.75 1.22 1.22 1.22 Sodium bicarbonate 4.0 - - - EudragitL-100-55 12.0 - - - Mannitol SD 200 20.0 - - - Sodium lauryl sulfate 0.375 0.48 0.48 0.48 Magnesium stearate 2.0 0.5 0,5 0.5 Talc 2.0 0.12 0.12 0.12 Colour q.s. q.s. _ .._q-s. q.s. Coating Ethyl cellulose (as aqueous dispersion Aquacoat® ECD 30) Coated to a weight gain of 8% by weight of the core Coated to a weight gain of 15% by weight of the core Coated to a weight gain of 15% by weight of the core Coated to a weight gain of 15% by weight of the core Dibutyl sebacate Triethyl citrate The oral drug delivery systems of Formulae I, II, III and IV were made as follows. Metoprolol succinate, HPMC, lactitol monohydrate and povidone K-30 were passed through ASTM (American Society for Testing and Materials) sieve # 40 and mixed suitably. The mixture thus obtained was granulated with purified water to a suitable end-point, and the granules obtained were dried to a moisture content of about 1-2%. The dried granules were milled suitably and lubricated with a mixture of sodium starch glycolate, colloidal silicon dioxide, talc and magnesium stearate, to obtain the blend for the first layer. Silicified microcrystalline cellulose, crospovidone, sodium lauryl sulfate and a suitable colour were passed through ASTM sieve #40 and mixed suitably. The blend so obtained was lubricated with a mixture of colloidal silicon dioxide and magnesium stearate (previously passed through ASTM sieve #60). In case of the system of Formula I, the blend also included metoprolol succinate, Eudragit L-100-55, sodium bicarbonate and Mannitol in amounts mentioned above. The above two preparations were compressed to obtain bilayer tablets, which were coated with an aqueous dispersion of ethyl cellulose to a suitable weight gain. An orifice was then drilled on one side of the tablet. The tablets thus obtained were subjected to dissolution testing. Tablets of Formula I were tested using United States Pharmacopoeia dissolution apparatus, type II, using 500ml of 0.0IN HC1 as the dissolution medium, at 100 rpm. Tablets of Formulae II, III and IV were tested using United States Pharmacopoeia dissolution apparatus, type II, using 500ml of pH 6.8 buffer as the dissolution medium, at 50 rpm. The results of the dissolution test are recorded in Table 2 below. Table 2 Time (hours) Percent drug released Formula I Formula II Formula III Formula IV 0.25 18 - - - 0.5 21 - - - 1.0 24 6 5 8 2.0 31 12 11 13 4.0 51 24 21 23 8.0 84 46 39 37 12.0 96 64 55 49 16.0 - 84 71 58 20.0 - 99 85 67 The release from the controlled release layer of all the four systems was zero-order, i.e. linear over time (regression co-efficient r2 being 0.9697, 0.9959, 0.9966 and 0.9816 for Formula I, II III and IV, respectively). Example 2 A controlled release pharmaceutical composition of bupropion hydrochloride was obtained as per the present invention, as detailed in Table 3 below. Table 3 Ingredients Quantity (mg/tab) Percent by weight First Layer Bupropion hydrochloride 150.0 37.5 Hydroxypropyl methylcellulose (HPMC K100M Premium) 20.00 5.0 Lactose anhydrous (DCL 21) 177.0 44.25 Polyvinylpyrrolidone (PVP K>30) 13.0 3.25 Colloidal silicon dioxide 4.0 1.00 Stearic acid 12.0 3.00 Talc 4.00 1.00 Sodium starch glycolate 20.00 5.0 Second layer Silicified microcrystalline cellulose (Prosolv SMCC 90) 205.0 70.7 Crospovidone 72.5 25.0 Colloidal silicon dioxide 7.2 2.5 Sodium lauryl sulfate 2.90 1.0 Magnesium stearate 2.4 0.83 Colour q.s. Coating Ethyl cellulose (as aqueous dispersion Aquacoat**) Coated to 14% by weight of the Dibutyl sebacate core tablet Bupropion hydrochloride, HPMC K100M lactose anhydrous, PVP K-30 and colloidal silicon dioxide were passed through ASTM sieve #40 and mixed thoroughly. Stearic acid and talc were passed through ASTM sieve # 60 and mixed with the blend, to obtain the composition of the first layer. Prosolv SMCC 90, colloidal silicon dioxide, sodium lauryl sulfate, crospovidone and colour were passed through ASTM sieve # 40 and mixed thoroughly to obtain a blend. This blend was lubricated with magnesium stearate, to obtain the composition of the second layer. The two compositions were compressed using standard concave punches to obtain bilayer tablets. The compressed tablets were coated with the coating composition to a weight gain of about 14% by weight of the core. An orifice was drilled on the side of the tablet that contained the second layer, i.e. the layer without bupropion hydrochloride. 20 The tablets thus obtained were subjected to dissolution testing using United States Pharmacopoeia dissolution apparatus, type II, using 900ml of water as the dissolution medium, at 50rpm. The results of the dissolution test are tabulated in Table 4 below. The release was zero-order, i.e. linear over time (regression co-efficient r2 = 0.97). Table 4 Time (hours) % drug released 1 6 2 13 3 18 4 22 6 31 8 37 10 43 12 49 16 56 20 67 24 74 Examples A controlled release pharmaceutical composition of oxybutynin chloride was obtained as per the present invention, as detailed in Table 5 below. Table 5 Ingredients Quantity (rag/tab) Percent by weiebt First Layer Oxybutynin chloride 3.75 5.36 Silicified microcrystalline cellulose (Prosolv SMCC 90) 46.64 66.62 Colloidal silicon dioxide 1.65 2.35 Crospovidone 16.56 23.65 Sodium lauryl sulfate 0.66 0.94 Colour 0.198 0.28 Magnesium stearate 0.53 0.76 Second layer Oxybutynin chloride 7.50 6.0 Hydroxypropyl methylcellulose (HPMC K4M) 20.0 16.0 Lactitol monohydrate 40.0 32.0 Citric acid, anhydrous 2.50 2.0 Microcrystalline cellulose (Avicel PH 102) 33.0 26.4 Sodium starch glycolate 20.0 16.0 Talc 1.00 0.8 Magnesium stearate 1.00 0.8 Coating Ethyl cellulose (as aqueous dispersion Aquacoat®) Coated to about 14% by weight of the core tablet Dibutyl sebacate Triethyl citrate The bilayered tablet was made as follows. Oxybutynin chloride was mixed with Prosolv SMCC 90, colloidal silicon dioxide, crospovidone, sodium lauryl sulfate, colour and magnesium stearate to obtain a first layer composition. The second layer composition was obtained by blending together a mixture of oxybutynin chloride, HPMC K4M, lactitol monohydrate and citric acid. The mixture was granulated using purified water and the granules so obtained were lubricated with a mixture of microcrystalline cellulose, sodium starch glycolate, talc and magnesium stearate. The first and second layer compositions were 'men compressed to obtain the bilayered tablets, which were then coated with a coating composition comprising aquacoat, dibutyl sebacate and triethyl citrate to a weight gain of about 14% by weight of the core tablet. The tablets thus obtained were subjected to dissolution testing using United States Pharmacopoeia dissolution apparatus, type II, using 900ml of pH 4.5 buffer as the dissolution medium, at lOOrpm. The results of the dissolution test are recorded in Table 6 below. The release from the controlled release layer was zero-order, i.e. linear over time (regression co-efficient r2 = 0.9904). Table 7 Ingredients Quantity (mg/tablet) Percent by weight First layer Oxybutynin chloride 3.75 5.36 Silicified microcrystalline cellulose (Prosolv SMCC 90) 46.64 66.62 Colloidal silicon dioxide 1.65 2.35 Crospovidone 16.56 23.65 Sodium lauryl sulfate 0.66 0.94 Colour 0.198 0.28 Magnesium stearate 0.53 0.76 Second layer Oxybutynin chloride 7.50 6.0 Hydroxypropyl methytcetlulose (HPMC K4M) 20.0 16.0 Lactitol monohydrate 40.0 32.0 Citric acid, anhydrous 2.50 2.0 Microcrystalline cellulose (Avicel PH 102) 33.0 26.4 Sodium starch glycolate 20.0 16.0 Tate 1.00 0.8 Magnesium stearate 1.0 0.8 Third layer Oxybutynin chloride 3.75 5.36 Silicified microcrystalline cellulose (Prosolv SMCC 90) 46.64 66.62 Colloidal silicon dioxide 1.65 2.35 Crospovidone 16.56 23.65 Sodium lauryl sulfate . 0.66 0.94 Colour 0.198 • 0.28 Magnesium stearate 0.53 0.76 Coating Ethyl cellulose (as aqueous dispersion Aquacoat®) Coated to about 14% by weight of the core tablet Dibutyl sebacate Triethyl citrate The three layers were obtained as mentioned in examples above and compressed to obtain the core, which was then coated with the coating solution to a weight gain of about 14% by weight of the core. An orifice of size 400,microns was drilled on one planar surface of the tablet. The trilayered tablets thus obtained were subjected to dissolution testing using United States Pharmacopoeia dissolution apparatus, type II, using 900ml of pH 4.5 buffer as the dissolution medium, at a speed of lOOrpm. The results of the dissolution testing are recorded in Table 8 below. Table 8 Time (hours) Percent drug released 0.5 28 1 36 2 51 4 63 6 70 8 73 12 78 ft 16 82 20 86 24 88 While the invention has been described by reference to specific embodiments, this was done for purposes of illustration only and should not be construed to limit the spirit or the scope of the invention. 25 We claim: 1. An oral drug delivery system comprising a coated tablet having one or more surfaces, the coated tablet further comprising: a core comprising an active ingredient composition comprising at least one active ingredient and a pharmaceutically acceptable excipient and a composition selected from a swellable composition and a reactive composition located in an immediate vicinity of one or more preselected surfaces, and a coating surrounding the core, wherein the coating is selected from a group consisting of defective coatings and reactive coatings, wherein the coating is operable to be reliably removed fully from the one or more of the preselected surfaces of the tablet upon contact with an aqueous environment, but not removed from at least one of the surfaces. 2. An oral drug delivery system as claimed in claim 1 wherein the defective coating comprises a coating with one or more passageways on the selected surfaces. 3. An oral drug delivery system as claimed in claim 2, wherein the coating is impermeable to the active ingredient. 4. An oral drug delivery system as claimed in claim 1 wherein the coating is semipermeable. 5. An oral drug delivery system as claimed in claim 1, wherein the active ingredient composition is present as one or more layers and the swellable composition is present as one or more layers. 6. An oral drug delivery system as claimed in claim 5, wherein the active ingredient present in the different layers may be the same or different. 7. An oral drug delivery system as claimed in claim 1, wherein the active ingredient composition comprises a controlled release composition. 26 8. An oral drug delivery system as claimed in claim 6, further comprising a second active ingredient composition, wherein the active ingredient composition comprises a rapid releasing composition and the second active ingredient composition contains the same active ingredient as the active ingredient composition, the second active ingredient composition comprising a controlled release composition. 9. An oral drug delivery system as claimed in claim 1, wherein the swellabie composition comprises a swelling agent. 10. An oral drug delivery system as claimed in claim 9, wherein the swelling agent is selected from a swellabie excipient, a gas generating agent and mixtures thereof. 11. An oral drug delivery system as claimed in claim 1, wherein the swellabie composition comprises wicking agents. 12. An oral drug delivery system as claimed in claim 1, wherein the swellabie composition comprises osmogents. 13. An oral drug delivery system as claimed in claim 1 wherein the active ingredient composition is released without a substantial delay after the tablet contacts an aqueous environment. 14. An oral drug delivery system as claimed in claim 1 further comprising an outer coating of a pH-dependent polymer. 15. An oral drug delivery system comprising a coated tablet having one or more surfaces, the coated tablet comprising: a core comprising an active ingredient composition comprising at least one active ingredient and a pharmaceutical^ acceptable excipient, and a coating surrounding the core, wherein the coating is operable to be reliably removed partially from one of the surfaces of the tablet upon contact with an aqueous environment, wherein the coating is selected from a group consisting of defective coatings and reactive coatings; 27 and wherein the core further comprises a composition selected from a swellable composition and a reactive composition, said composition being in a form of an in-lay tablet, said in-lay tablet being located in an immediate vicinity of said one of the surfaces from which the coating is operable to be partially removed. 28 16. An oral drug delivery system as claimed in claim 1 wherein the swellable or reactive composition comprises a swelling agent selected from a swellable excipient, gas generating agents and mixtures thereof, and optionally wicking agents and/or osmogents.

Documents:

987-MUM-2003-ABSTRACT(30-6-2004).pdf

987-MUM-2003-ABSTRACT(GRANTED)-(23-1-2009).pdf

987-MUM-2003-ANNEXURE TO FORM 3(19-7-2006).pdf

987-MUM-2003-ANNEXURE TO FORM 3(2-6-2006).pdf

987-MUM-2003-ANNEXURE TO FORM 3(21-11-2007).pdf

987-MUM-2003-ANNEXURE TO FORM 3(22-6-2006).pdf

987-MUM-2003-ANNEXURE TO FORM 3(4-8-2006).pdf

987-MUM-2003-CANCELLED PAGES(17-5-2006).pdf

987-MUM-2003-CLAIMS(30-6-2004).pdf

987-MUM-2003-CLAIMS(8-10-2008).pdf

987-MUM-2003-CLAIMS(AMENDED)-(17-5-2006).pdf

987-MUM-2003-CLAIMS(GRANTED)-(23-1-2009).pdf

987-MUM-2003-CORRESPONDENCE(1)-(10-4-2006).pdf

987-MUM-2003-CORRESPONDENCE(2)-(21-11-2007).pdf

987-MUM-2003-CORRESPONDENCE(20-5-2009).pdf

987-MUM-2003-CORRESPONDENCE(23-5-2006).pdf

987-MUM-2003-CORRESPONDENCE(24-10-2009).pdf

987-MUM-2003-CORRESPONDENCE(29-9-2008).pdf

987-MUM-2003-CORRESPONDENCE(IPO)-(11-2-2009).pdf

987-MUM-2003-CORRESPONDENCE(IPO)-(3-3-2006).pdf

987-MUM-2003-DEED OF ASSIGNMENT(8-10-2008).pdf

987-MUM-2003-DESCRIPTION(COMPLETE)-(30-6-2004).pdf

987-MUM-2003-DESCRIPTION(COMPLETE)-(8-10-2008).pdf

987-MUM-2003-DESCRIPTION(GRANTED)-(23-1-2009).pdf

987-MUM-2003-DESCRIPTION(PROVISIONAL)-(19-9-2003).pdf

987-MUM-2003-DRAWING(3-4-2006).pdf

987-MUM-2003-DRAWING(30-6-2004).pdf

987-MUM-2003-DRAWING(GRANTED)-(23-1-2009).pdf

987-MUM-2003-FORM 1(19-9-2003).pdf

987-MUM-2003-FORM 1(23-9-2003).pdf

987-MUM-2003-FORM 1(29-9-2003).pdf

987-MUM-2003-FORM 1(8-10-2008).pdf

987-MUM-2003-FORM 18(12-9-2005).pdf

987-MUM-2003-FORM 2(COMPLETE)-(30-6-2004).pdf

987-MUM-2003-FORM 2(GRANTED)-(23-1-2009).pdf

987-MUM-2003-FORM 2(PROVISIONAL)-(19-9-2003).pdf

987-MUM-2003-FORM 2(TITLE PAGE)-(8-10-2008).pdf

987-MUM-2003-FORM 2(TITLE PAGE)-(COMPLETE)-(30-6-2004).pdf

987-MUM-2003-FORM 2(TITLE PAGE)-(GRANTED)-(23-1-2009).pdf

987-MUM-2003-FORM 2(TITLE PAGE)-(PROVISIONAL)-(19-9-2003).pdf

987-MUM-2003-FORM 2(TITLE PAGE)-(SUPERSEDED)-(16-12-2005).pdf

987-MUM-2003-FORM 3(23-5-2006).pdf

987-MUM-2003-FORM 3(3-6-2005).pdf

987-MUM-2003-FORM 3(3-8-2004).pdf

987-MUM-2003-FORM 3(6-6-2005).pdf

987-MUM-2003-FORM 4(3-4-2006).pdf

987-MUM-2003-FORM 4(5-4-2006).pdf

987-MUM-2003-FORM 5(30-6-2004).pdf

987-mum-2003-form 6(8-10-2008).pdf

987-MUM-2003-MARKED COPY(16-12-2005).pdf

987-MUM-2003-OTHER DOCUMENT(16-12-2005).pdf

987-MUM-2003-PCT-ISA-237(16-12-2005).pdf

987-MUM-2003-POWER OF ATTORNEY(3-5-2006).pdf

987-MUM-2003-POWER OF ATTORNEY(8-10-2008).pdf

987-MUM-2003-SPECIFICATION(AMENDED)-(16-12-2005).pdf

987-MUM-2003-SPECIFICATION(AMENDED)-(3-4-2006).pdf

987-MUM-2003-WO INTERNATIONAL PUBLICATION REPORT A1(16-12-2005).pdf

987-MUM-2003-WO INTERNATIONAL PUBLICATION REPORT A3(16-12-2005).pdf

987-MUM-2003-WO INTERNATIONAL PUBLICATION REPORT(30-6-2004).pdf

987mum2003-claims(granted)-(08-10-2008).doc

987mum2003-claims(granted)-(08-10-2008).pdf

987mum2003-correspondence(1)-(10-04-2006).pdf

987mum2003-correspondence(2)-(21-05-2008).pdf

987mum2003-correspondence(ipo)-(23-01-2009).pdf

987mum2003-drawing(30-06-2004).pdf

987mum2003-form 1(08-10-2008).pdf

987mum2003-form 1(23-09-2003).pdf

987mum2003-form 1(29-09-2003).pdf

987mum2003-form 2(granted)-(08-10-2008).doc

987mum2003-form 2(granted)-(08-10-2008).pdf

987mum2003-form 3(03-06-2005).pdf

987mum2003-form 3(03-08-2004).pdf

987mum2003-form 3(05-02-2005).pdf

987mum2003-form 4(03-04-2006).pdf

987mum2003-form 5(30-06-2004).pdf

987mum2003-form 6(08-10-2008).pdf

987mum2003-form-pct-isa-210(16-12-2005).pdf

987mum2003-power of attorney(29-04-2006).pdf

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