Title of Invention

NANOPARTICULATE ACTIVE SUBSTANCE FORMULATIONS

Abstract

The invention relates to nanoparticulate formulations comprising at least one active compound or compound with a special effect and at least one random radical copoly mer. The copolymers are formed from monomers carrying sulfonic acid groups and additional olefinically unsaturated compounds. The formulations are dispersible as nanoparticles in an aqueous medium. The invention includes, in addition, processes for the preparation of the solid and liquid formulations, and their use.

Full Text

Nancparticulate active substance formulations Description The present invention relates to active compound formulations which, in addition to at least one active compound, comprise at least one random radical copolymer, which comprises, as monomer unite, at least one olefinically unsaturated sulfonic acid i) or a salt thereof or a mixture of acid and salt and at least one alky}-, aryt-, alkylaryl-, ary! alkyl-, aryloxyalkyi-, alkoxyaryl- or hydroxyalkyl-substituted (meth)acrylate or (meth)acryiamide ii), and if appropriate additional additives. The invention additionally relates to processes for the preparation of the active com¬pound formulations, dispersions which are prepared by redispersing these active com¬pound formulations in aqueous systems, and the use of these active compound formu¬lations. Many active compounds are ideally provided in the form of aqueous systems. This naturally makes more difficult an effective application of active compounds virfiich are insoluble or only slightly soluble in water, since the bioavailability and accordingly the biological activity are low. Many active compounds, especially in the agricultural and pharmaceutical fields, are hydrophobic by nature and therefore are subject to the abo¬vementioned problem of application. It is known that solubility, dispersibility and bioavailability of active compound particles can be increased by expanding the particle surface area, i.e. by reducing the particle size at an klentical total amount. For example, the penetration of biological membranes is simplified at a smaller particle size. This simultaneously means that, in comparison with the application of the active com¬pound in the form of larger particles, the amounts of active compound necessary to achieve the same effect are smaller virtien particles in the size range of 1 micrometer and less are used. Sur^ce active substances, which inhibit crystal grovrth and agglomeration, are fre-quentiy used to stabilize nanoparticulate systems. Typical stabilizers are low-molecular-weight surfactants or oligomers which result in the fonnation of micelles. The active compound content of such micelles is often low, vt^ich is disadvantageous. However, high-molecular-weight auxiliaries, such as, for example, ailloids, amphiphiiic polymers and thickeners, also raise the possibility of stabilizing small active compound particles. While the abovementioned protective colloids stabilize the particles against agglomera¬tion by covering the surfece and leading to repulsive electrostatic and/or steric interac¬tions between the particles, thickeners stabilize kinetically by slowing down the diffu¬sion and accordingly the rate of collision between the particles. wo 97/13503 reveals a method for of preparation of nanoparticles, in which an agent and a matrix in solution are brought together in order then to be produced in a spray drying step as a nanocomposite povwier w^ich can be redispersed In an aqueous me¬dium. The nanoparticles produced in such a way are smaller than 5000 nm, particularly preferably smaller than 250 nm. In addition to therapeutic and diagnostic agents, inter alia, pesticides are also mentioned as possible applications. Carbohydrates, proteins, inorganic salts, resins or lipids are mentioned as matrix mate¬rials, gelatin, starch, polyvinylpyn-olidone, arabinogalactan, polyvinyl alcohol, poly-acrylic acid, polyethylene, polymethacrylates, polyamide. poly(ethylene-co-vinyl ace¬tate) and shellac being mentioned as resins and celluloses being mentioned as carbo¬hydrates. Additional components, such as stabilizers and surfactants, have to be added for the redtspersing. EP-A 0 275 796 reveals a process for the preparation of colloldally dispersible systems by the formation of spherical nanoparticles. The process comprises the dissolution of a first component A in a solvent or mixture of solvents, to which surface-active agents are optionally added, and the preparation of a second solvent or mixture of solvents, which second solvent or mixture of solvents does not dissolve the component A. In addition, surface-active agents are optionally added to the second solvent or mixture of solvents and the second solvent/mixture of solvents is misclble in any proportion with the sol-vent/mi)tture of solvents of the component A. On mixing the solution of the component wflth the second solvent/mixture of solvents in a mixing chamber with control of the mix¬ing and residence time (micronizing), nanoparticles with a size of less than 500 nm are formed. Polymers, fats, fatty acid esters, biologically active substances, pigments, lu¬bricants or dyes are mentioned as possible components A. WO 98/16105 reveals solid plant protection preparations consisting essentially of one or more predominantiy amorphous solid per se plant protection active compounds with a solubility in water of less than 500 mg/l at 25°C and a coating layer surrounding the active compounds. The preparation is produced by mixing a liquid formulation of the plant protection active compound with a liquid formulation of a coating material and drying the plant protection active compound coated in such a way. Preferred solvents are volatile water-miscible solvents. The dried nanoparticles can be redispersed in aqueous media, the particle sizes are 0.1 to 0.8 micrometer. Surface-active polymeric colloids or oligomeric amphiphilic compounds or mixtures thereof are suitable as coat¬ing layer materials. Biopolymers and modified biopolymers are preferably used. In addi¬tion, synthetic anionic and neuti-al polymers, for example such as polyvinyl alcohol, polyvinylpyrroiidone and polyacrylic add, are suitable. wo 03/039249 refers to a solid plant protection formulation formed from a plant protec¬tion agent and a random radical copolymer which comprises at least one hydrophilic and one hydrophobic monomer as polymerized units and optionally additional addi¬tives. In the aqueous dispersion described, at least 50% of the dispersed particles are found in a state which is amorphous by X-rays. Procationic nifrogen-comprising com¬pounds, such as vinyl-substituted pyridines or aminoalkyl-substituted {meth)acrylamides, are used as hydrophilic monomers. EP-A0 875 143 reveals pesticidal compositions with a polymer content of 0.01 to 40% by weight in which at least one of the components is a polymer whidi reduces the crys¬tallization of the pesticidal active compound of the composition. The polymers can have a lipophilic or both a lipo- and hydrophilic character. The hy¬drophilic character is fixed by monomer unfts chosen from substituted alky! esters, alkyi Ihioesters and mono- or dialkylamides of monoethylenically unsaturated monomers, such as acrylic acid, methacryllc acid, fumaric add, maleic acid and itaconic acid, sut>-stituted or unsubstituted vinyl esters of Ci-C4-carboxylates, cyclic esters, amides and heterooycles and vinyl-substituted amines. The lipophilic character is conferred on the polymers by ethylenically unsaturated monomers, such as long-chain alkyi esters and mono- or disubstituted alkylamides of acrylic acid, methacryllc acid, fumaric acid, maleic acid or itaconic acid, by a-olefins or vinyl alcohol esters, vinyl halides, vinylnitriles and vinyl carboxylates. WO 02/082900 describes aqueous suspensions of nanoparticles. The nanoparticles are formed from an amphiphilic compound with at least one hydrophobic and at least one hydrophilic unit and at least 50 percent by weight of an organic water-insoluble agrochemical substance based on 100 parts of the amphiphilic compound, Amphiphilic diblock copolymers are revealed as compatibilizers. DE-A 10151392 describes pov^rdered active compound fomulations consisting of a biological active compound, a dispersant, polyvinyl alcohol and if appropriate additives. In this connection, the active compound and the dispersant are suspended in an aque¬ous phase and heated until molten; an emulsion is formed. This emulsion is homoge¬nized witti a jet disperser and is then rapidly cooled until the dispersed melt solidifies. The finely divided dispersion is then treated with an aqueous polyvinyl alcohol solution, whereby a film of polyvinyl alcohol is formed which encloses the particles of the disper¬sion. EP-A 0 875 142 reveals dispersions of plant protection active compounds in agricul¬tural oils and a method for the preparation of these dispersions. The size of the dis¬persed particles is between 0.5 and 10 micrometers. The polymers used to disperse the active compounds consist of from 2.5 to 35% by weight of polar monomers. Mono¬mers carryirig hydroxy!, carboxylic add and nitrogen groups are used as polar mono- mers. Preferred monomers are long-chain (meth)acrylates and, as polar monomer, dimethylaminopropylmethacrylamide (DMAPMA). It was an object of the present invention to provide new possibilities for the fomiulation of active compounds, in particular for the nanodispersing in an aqueous medium of active compounds which per se have low solubility in water. The present invention relates to active compound formulations comprising a. at least one active compound, b. at least one random radical copolymer comprising, as monomers, at least one otefinically unsaturated sulfonic acid of the formula I in which X is oxygen or NR^, R^ is hydrogen or methyl, n can take a value from 0 to 10, R^ and R^ are, independently of one another, Ci-Ce-alkyI, and R^ is hydrogen, alkyl, aryl, alkylaryl, arylalkyi, alkoxyalkyl, aryloxyalkyi, alkoxyaryl, hydroxyalkyi, (di)alkylaminoalkyl, (di)alkylaminoaryl, {di)arylaminoalkyl, alkylarylaminoalkyl or alky-larylaminoaryl, it being possible for the aryl radicals to be substituted, and wtiere the otefinically unsaturated sulfonic acid can be present in the acid or salt form or as a mix¬ture of the acid and salt fonns, at least one olefinically unsaturated monomer of the fomnula II in which Y is oxygen or NR^, R"" is hydrogen or methyl, and R^ and R^ are, independ-entiy of one another, hydrogen, alkyl, aryl, alkylaryl, arylalkyi, alkoxyalkyl, aryloxyalkyi, alkoxyaryl, hydroxyalkyi, (dijalkylaminoalkyi, (di)alkylaminoaryl, (di)ary!aminoalkyl, alky¬larylaminoalkyl or alkylaryiaminoaryl, option3Uy..addittonal monomers, and c. if appropriate additional additives. Salts of the sulfonic acid of the formula I are preferably alkali metat or ammonium salts. Ci-C2o-alkyl are suitable as alkyl radicals, alone or in the abovementioned combina¬tions. Mention may in particular be made of C-Cg-alkyl, such as methyl, ethyl, propyl. 1-methylethyl. butyl, 1-methylpropyl, 2-methylpropyl, 1,1-dimethylethyl, pentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, Llndimethylpropyl, 1,2-dimethylpropyl, 2,2-dimethylpropyl, 1-ethylpropyl, hexyl, 1-methylpentyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl, 1,3-dimethylbutyl, 2,2-dimethylbutyl, 2,3-dimethylbutyl, 3,3-dimethylbutyl, 1-ethylbutyl, 1,1,2-trimethylpropyl, 1,2,2-trimethylpropyl, 1-ethyl-1-methylpropyI and 1-ethyl-2-methylpropyl. cyclohexyl, n-heptyl, n-octyl, 2-ethylhexyl, decyl, isodecyl, undecyl, lauryl, tridecyl, myristyl, pentadecyl, cetyl, heptadecyl or stearyl. Aryl radicals is to be understood as meaning mono- or polycyclic, if appropriate substi¬tuted, aromatic hydrocarbon radicals. Mention may be made, by way of examples, of phenyl, naphthyl or phenyl substituted by halogen, such as fluorine or chlorine. Alkoxy is an alkyl radical bonded via an oxygen atom (-0-) to the backbone. Aryloxy Is an aryl radical bonded via an oxygen atom (-0-) to the backbone. Additional monomers can comprise, for example, vinylaromatic monomers, such as styrene and styrene derivatives, such as a-methylstyrene, vinyltoluene, ortho-, meta-and para-methylstyrene, ethylvinylbenzene, vinylnaphthalene, vinylxylene and the cor¬responding halogenated vinylaromatic monomers, or vinylaromatic monomers carrying nitro, alkoxy, haloalkyi, alkoxycarbonyl, carboxyl, amino and atkylamino groups, a-olefins, such asethene. propene. 1-butene, 1-pentene, 1-hexene, isobutene, orot-olefins comprising long-chain (Cio-C2o)alkyls, dienes, such as butadiene and isoprene, vinyl alcohol esters, such as vinyl acetate, wnyl halides, such as vinyl chloride, vinyl bromide or vinyl fluoride, vinylidene chloride, vinylidene fluoride, vinylidene bromide, vinylnitrile, vinyl carboxylates, 1-vinylamides, such as 1-vinylpyrro!idone, 1-vinylpiperidone, 1-vinylcaprolactam, 1-vinylformamide, 1-vinylacetamideor 1-methyl-1-vinylacetamkle, N-vinylimidazole, Ci-C24-alkyl esters and mono- and disubstituted and unsubstituted C,-C24-alkylamides of monoethylenicaity unsaturated monomers, such as acrylic add, methacrylic acid, fumaric acid, maleic acid and itaconic acid, vinylsulfonic acid, anhydrides, such as maleic anhydride, unsaturated aldehydes, such as acrolein, or unsaturated ethers, such as 1,4-cyclohexanedimethanol divinyl ether, 1,4-cyclohexanedimethanol monovinyl ether, butanediol divinyl ether, butanediol monoviny! ether, cyclohexyl vinyl ether, diethylene glycol divinyl ether, ethylene glycol monovinyl ether, ethyl vinyl ether, methyl vinyl ether, n-butyl vinyl ether, octadecyl vinyl ether, tri-ethylene glycol vinyl methyl ether, vinyl isobutyl ether, vinyl {2-ethylhexyl) ether, vinyl propyl ether, vinyl isopropyl ether, vinyl dodecyl ether, vinyl tert-butyl ether, hexanediol divinyl ether, hexanediol monovinyl ettrer, diethylene glycol monovinyl ettier, diethyt-aminoethyi vinyl ether, polytetrahydrofuran-290 divinyl ether, tetraethylene glycol divi- nyl ether, ethylene glycol butyl vinyl ether, ethylene glycol divtnyl ether, triethylene gly¬col divinyl ether, trlmethylolpropane trivinyl ether or aminopropyl vinyl ether. A polymer described with "radical" is to be understood as meaning a polymer prepared by a radical polymerization. A copolymer described with "random" is to be understood as meaning a copolymer in which the monomer sequence is detemiined by the copolymerization parameters of the monomers. This is correspondingly valid also for copolymers consisting of more than two types of monomer. Polymers of this type are also described as statistical copolymers. The sulfonic acids of the formula 1 can be present in the acid or salt form or as a mix¬ture of the acid and salt forms. The term "sulfonic acid" is used for all these fonns. Salts of the sulfonic acid are metal salts, in particular alkali metal salts, such as lithium, sodium or potassium salts, or ammonium salts. In a prefen-ed embodiment, the random radical copolymer according to the invention comprises, as monomers, at least one olefinically unsaturated sulfonic acid of the for¬mula I, at least one (meth)acrylate of the formula lla in which Y is O or NR^ R"° is hydrogen or methyl, and R^ and R^ are hydrogen, ai-kyl, aryl, alkylaryl, arylalkyi, alkoxyalkyl, aryloxyalkyl, alkoxyaryl, hydroxyalkyi, (di)atkytaminoalky[, (di)alkylaminoaryl, (di}arylaminoalkyl, alkylarytamlnoalkyl or alky-larylaminoaryl, it being possible for Uie aryl radicals to be substituted. In this connection, alkoxy is an alkyl radical as mentioned above which is bonded via an oxygen atom to the backbone. Aryloxy is an aryl radical which is bonded via an oxy¬gen atom (-0-) to the backbone. Aryl radicals is to be understood as meaning mono- or polycyclic, if appropriate substi¬tuted, aromatic hydrocarbon radicals. Mention may be made, by way of examples, of phenyl, naphthyl or phenyl substituted by halogen, such as fluorine or chlorine. Aryloxy is an aryl radical as mentioned above which is bonded via an oxygen atom to the back¬bone. By way of example, alkylaryl is tolyl, arylalky} is benzyl, alkoxyalkyl is ethoxyethyl, aryl-oxyalkyl is phenoxyethyl, alkoxyaryl is methoxyphenyi. hydroxyalkyi is hydroxyethyl and (di)alkylaminoalkyl is dimethylaminopropyl. In a particularly prefen-ed embodiment, the random radical copolymer according to the invention is formed from at least one olefinically unsaturated sulfonic acid of the for¬mula I and phenoxy-Ci-Cs-alkyI acrylate, such as, for example, phenoxyethyl acrylate. In an additional preferred embodiment, the random radical copolymer is fornied from monomers of the above formula I, in particu(ar2-acrylamrdo-2-methyl-1-propanesulfonic acid, and at least one olefinically unsaturated monomer of the formula II in which Y is oxygen or NR^, R"* is hydrogen or methyl, and R^ and R^ are hydrogen, alkyl, aryl, alkylaryl, arylalkyl, alkoxyalkyl, aryloxyalkyi, alkoxyaryl, hydroxyalkyi, (di)alkylaminoalkyl, (di)atkylaminoaryl, (di)arylaminoa!kyl, alkylarylaminoalkyl or alky-laryiaminoaryl, in which alkyl and aryl have the abovementioned meanings, and option¬ally additional monomers. in an additional particuJarfy preferred embodiment, the random radical copolymer com¬prises, as monomers, 2-acrylamido-2-methyl-1-pnDpanesulfonic acid and at least one olefinically unsaturated monomer of the formula il, in which Y is oxygen, R^ is hydrogen and R^ is hydrogen or alkyl. Accordingly, the random radical copolymer comprises, in this particularly preferred em-IxKJiment, as monomers, 2-acrylamido-2-methyl-1-propanesulfonic add and at least one ester of acrylic acid. Such esters of acrylic acid are, for example, methyl acrylate, ethyl acrylate, propyl acry¬late, isopropyl acrylate, butyl acrylate, 2-methylpropyl acrylate, tert-butyl acrylate, hexyl acrylate, cydohexyl acrylate, n-octyl acrylate, 2-ethylhexyl acrylate, decyl acrylate, iso- decyl acrylate, undecyl acrylate, lauryl acrylate, tridecyl acrylate, myristyl acrylate, pen-tadecyl awylate, cetyl acrylate, heptadecyl acrylate or stearyl acrylate. In a very particularly preferred embodiment, the random radical copolymer comprises, as monomers, 2-acrylamido-2-methyl-1-propanesulfonic acid, phenoxyethyl acrylate and at (east one ester of acr^ic acid. In an additional very particularly preferred embodiment, the random radical copolymer is formed from the monomers 2-acrylamido-2-methyl-1-propanesulfonic acid and phe¬noxyethyl acrylate. The molar weights Mw and Mn, and the polydlspersity of the polymers, are detemiined by size exclusion chromatography. Commercial PMMA standard units can be used as calibration material. According to the invention, the proportion in percent of the at least one olefinically un¬saturated sulfonic acid in the total weight of the at least one random radical copolymer is 10 to 90, preferably 20 to 80 and particularly preferably 30 to 70 percent by weight. The random radical copolymers according to the invention are preferably synthesized in a conventional way by free radical polymerization. However, other, e.g. controlled radical, processes can also be used for the polymerization. The polymerization is car¬ried out in the presence of the monomers and one or more initiators and can be carried out with or without solvent, in emulsion or in suspension. TTw polymerization can be carried out as a batch reaction, in a semicontinuous opera¬tion or in a continuous operation. The reaction times generally range between 1 and 12 hours. The temperature region in vtrtiich reactions can be carried out generally extends from 20 to 200-0, preferably from 40 to 120°C. Conventional radical-forming substances are used as initiator for the radical polymeri¬zation. The initiator is preferably chosen from the group of the azo compounds, the peroxide compounds or the hydroperoxide compourKls. Mention may be made, by way of examples, of acetyl peroxide, benzoyl peroxide, lauroyl peroxide, tert-butyl peroxy-isobutyrate. caproyl peroxide, cumene hydroperoxide, azobisisobutyronitrile or 2,2"-azobis(2-methylbutanenitrile). Azobisisobutyronitrile (AIBN) is particulariy prefen-ed. The radical polymerization is preferably canied out in solution. Solvents are water, al-cohols, such as. e.g., methanol, ethanol or isoprc^anol, dipolar aprotJc solvents, such as. e.g., DMF, DMSO or NMP, or halogenated or nonhalogenated aromatic or aliphatic hydrocartxjns, such as. e.g., hexane, chlorobenzene, toluene or benzene. Preferred solvents are isopropanol, methanol, toluene, DMF, NMP, DMSO and hexane; DMF is particulariy preferred. According to the invention, the ratio of the proportion by weight of active connpound{s) to the proportion by weight of random radical copolymer(s) ranges from 1:10 to 10:1, preferably from 1:4 to 4:1, particularly preferably from 1:2 to 2:1. Suitable active compounds within the meaning of the present invention are preferably active compounds which are sparingly soluble in water, such as biologically or pharma-ceutically active compounds, but also substances witii a special effect which are spar¬ingly soluble in water, such as colorants, fragrances, flavorings, and active substances and substances with a special effect used in cosmetics. Sparingly soluble in water means a solubility in water of less than 1000 mg/l, preferably less than 100 mg/l, in each case at a temperature of 20""C. In the formulations according to the invention, several such active compounds can be present simultaneously. The invention preferably relates to the formulation of plant protection active com¬pounds, the preparation of these plant protection formulations in dispersed form, and preparations and processes for combating pests and undesirable vegetation by use of the plant protection formulation according to the invention. Mention may be made, as plant protection active compounds, of fungicides, bacteri¬cides, insecticides, acancides, nematicides, molluscicides, herbicides and plant growrth regulators. Preferred plant protection active compounds are herbicides, acaricides, insecticides, nematicides and fungicides listed under http://wviftiv.hclrss.demon.co.uk/irdex_cn_frame.html (Index of common names). Men¬tion may be made, as examples, of the following herbicides, acaricides, insecticides, nematicides and fungicides: Abamectin, acephate, acequinocyl, acetamiprid, acethion, acetochlor, acetoprole, acifluorfen, aclonifen, ACN, acrinattirin, acrolein, acrylonrtrile, acypetacs, alachlor, alanap, alanycarb, aldicarb, aldimorph, aldoxycarb, aldrin, allethrin, d-trans-allethrin, allidochlor, allosamidin, alloxydim, ally! alcohol, allyxycarb, alorac, alpha-cypermethrin, ametridione, ametryn, ametryne, amibuzin, amicarbazone, amidithion, amidoflumet, amidosulfuron, aminocarb, aminotriazole, amiprofos-methyl, amiton, amitraz, amitrole, ammonium sulfamate, ampropylfos, AMS, anabasine, anilazine, anilofos, anisuron, arprocarb, arsenous oxide, asulam, alhidathion, atraton, atra^ne, aureofungin, aver-mectin B1, azaconazole, azadirachtin, azafenidin, azamethiphos, azidithion, azimsutfu-ron, azinphosettiyl, azinphosmethyl, aziprotryn, azithiram, azobenzene, azocyclotin, azothoate, azoxystrobin, barban (= barbanate), barium hexafluorosilicate, barium poly- sulfide, barium silicofluoride, barthrin, BCPC, beflubutamid, benalaxyl, benazolin, ben-diocarb, bendioxide, benefin (= benfluraiin), benfuracarb, benfuresate, benodanil, be-nomyl, benoxafos, benquinox, bensulfuron, bensuiide, bensultap, bentaluron, benta-zon, benthiocarb, benzadox, benzalkonium chloride, benzamachl, benzamizole, ben-zamorf, benzene hexachloride, benzfendizone, benzipram, benzobicyclon, benzoepin, benzofenap, benzofluor, benzohydroxamic acid, benzomate benzoximate (= benzoyl-prop), benzthiazuron, benzyl benzoate, beta-cyfluthrin, beta-cypermethrin, bethoxazin, BHC, gamma-BHC, bialaphos, bifenazate, bifenox, bifenthrin, bilanafos, binapacryl, bioallethrin, bioethanomethrin, blopermethrin, bioresmethrin, biphenyl, bispyribac, bis-trifluron, bitertanol, bithionol, blasticidin-S, borax, Bordeaux mixture, BPPS, bromacil, bromchlophos, bromfenvinfos, bromobonil, bromobutide, bromocycien, bromo-DDT, bromofenofflm, bromomethane, bromophos, bromophos-ethyl, bromopropylate, bro-moxynil, brompyrazon, bromuconazole, BRP, bufencarb, bupirimate, buprofezin. Bur¬gundy mixture, butacarb, butachlor, butafenacil, butam, butamrfos, butathiofos, bu-tenachlor, buthidazole, buthiobate, buthiuron, butocarboxim, butonate, butoxycarboxim, butralin, butroxydim, buturon, butylamine, butylate, butylchlorophos, cacodylic acid, cadusafos, cafenstrole, caffeine, calcium arsenate, calcium chlorate, calcium cyana-mide, calcium polysulfide, cambendichlor, camphechlor, captafol, captan, carbam, car-bamorph, carbanolate, carbaryl, carbasulam, carbathion, carbendazim, carbetamide, carbofuran, carbon disulfide, carbon tetrachloride, carbophenothion, carbophos, carbo-sulfan, carboxazole, carboxin, carfentrazone. carpropamid, cartap, carvone, CDAA, CDEA, CDEC, CEPC, cerenox, cevadilla, Cheshunt mixture, chinalphos, chinalphos-methyl, chinomethionat, chlobenthiazone, chlomethoxyfen, chlor-IPC, chloramben, chloraniformethan, chloranil, chloranocryl, chlorazifop, chlorazine, chlorbenside, chlor-bicycJen, chlorbromuron, chlorbufam, chlordane, chlordecone, cbiordimeform, chlo-rethoxyfos, chloreturon, chlorfenac, chlorfenapyr, chlorfenazole, chlorfenethol, chlor-fenidim, chlorfenizon, chlorfenprop, chlorfenson, rfilorfensulphide, chlorfenvinphos, chlorfenvinphos-methyl, chlorfluazuron, chlorflurazole, chlorflurecoi, chlorflurenol, chloridazon, chlorimuron, chlorinate, chionnephos, chlormethoxynil, chlomitrofen, chloroacetic acid, chlorobenzilate, chlorofomn, chloromebuform, chloromethiuron, chloroneb, chlorophos, chloropicrin, chloropon, chloropropylate, chlorothalonil, chloro-toluron, chloroxifenidim (= chloroxuron), chloroxynil, chlorphoxim, chlorprazophos, chlorprocarb, chlorpropham, chlorpyrifos, chlorpyrifos-meth^, chlorquinox, chlorsulfu-ron, chlorthat, chlorthiamid, chlorthiophos, chlortoluron, chlozolinate, chromafenozide, cinerin I, cinerin 11, cinmethylin, cinosulfuron, cisanilide, cismethrin, clethodim, climba-zole, ciiodinate, clodinafop, cloethocarb, clofentezine, clofop, clomazone, clomeprop, cloprop, cloproxydim, clopyralid, doransulam, closantel, clothianidin, clotrimazole, CMA, CMMP, CMP, CMU, copper acetate, copper acetoarsenite, copper arsenate, copper cartjonate, basic, copper hydroxide, copper naphthenate, copper oleate, copper oxychloride, copper 8-quinolinolate, copper silicate, copper sulfate, copper sulfate, ba¬sic, copper zinc chromate, coumaphos, coumithoate, 4-CPA, 4-CPB, CPMF, 4-CPP, CPPC, cresol (= cresylic acid), crotamiton, crotoxyfos, crufomate, cryolite, cufraneb. cumyluron. cuprobam, cuprous oxide. CVMP, cyanatryn, cyanazine, cyanofenphos, cyanophos, cyanthoate, cyazofamid, cyclafuramid, cyclethrin, cycioafe, cycloheximide, cycloprothrin, cyclosulfamuron, cycloxydim, cyflufenamid. cycluron, cyfiuthrin. beta-cyfiuthrin, cyhalofop, cyhalothrin, gamma-cyhalothrin, lambda-cyhalothrin, cyhexatin, cymoxanil, cypendazole, cypermethrin, alpha-cypermethrin, beta-cypermethrin, theta-cypermethrin, zeta-cypermethrin, cyperquat, cyphenothrin, cyprazine, cyprazole, cy-prex, cyproconazole, cyprodinil, cyprofuram, cypromid, cyromazine, cythioate, 2,4-D, 3.4-DA. daimuron, dalapon, dazomet. 2,4-DB, 3,4-DB, DBCP, DCB, DCIP, DCPA (USA), DCPA (Japan), DCU, DDD, DDPP, DDT, pp (pure)-DDT, DDVP. 2.4-DEB, de-bacarb, decafentin, decarbofuran, dehydroacetic acid, deiquat, delachlor, delnav, del-tamethrin, demephion, demephion-0, demephion-S, demeton, demeton-methyl, deme-ton-0, demeton-0-methyl, demeton-S, demeton-S-methyl, demeton-S-methylsulphon (= demeton-S-methyl sulphone), DEP, 2.4-DEP, depallethrine, derris, 2,4-DES, des-medipham, desmetryn (= desmetryne), diafenthiuron, dialifos, diallate, diamidafos, dianat, diazinon, dibrom, 1,2-dibromoethane, dicamba, dicapthon, dichlobenil, di-chlofenthion, dichlofiuanid, dichlone, dichloralurea, dichlorfenidim, dichlormate, o-dichlorot>enzene, p-dichlorobenzene, 1,2-dichloroethane, dichloromethane, dichloro-phen, 1,2-dichloropropane, 1,3-dichloropropene, dichlorprop, dichlorprop-P, dichlorvos, dichlozoline, diclobutrazol, diclocymet, diclofop, diclomezine, dicloran, diclosulam. dico-fol, dicresyl, dicrotophos, dicryl, dicyclanil, dieldrin, dienochlor, diethamquat, diethatyl, diethion, diethofencarb, diethyl pyrocarbonate, difenoconazole, difenopenten, difenoxuron, difenzoquat, diflubenzuron, diflufenican (= diflufenicanil), diflufenzopyr, diflumetorim, dilor, dimefox, dimefuron, dimehypo, dimepiperate, dimetan, dimeth-achlor, dimethametryn, dimethenamid, dimethenamid-P, dimethirimol, dimethoate, di-methomofph, dimethrin, dimethylvinphos, dimeiiian. dimexano, dimidazon, dimox-ystrobin, dimpylate, dinex, diniconazole, diniconazole-M, dinitramine, dinobuton, dino-cap, dinocap-4, dinocap-6, dinocton, dinofenate, dinopenton, dinoprop, dinosam, di-noseb, dinosulfon, dinotefuran, dinoterb, dinoterbon, diofenolan, dioxabenzofos, diox-acarb, dioxathion, diphenamid, diphenyl sulfone, diphenylamine, diphenylsulphide, dipropetryn, dipterex, dipyrittiione, diquat, disugran, disul, disulfiram, disulfoton, ditalim-fos, dithianon, dithicrofos, dithiometon, dithiopyr, diuron, dlxanthogen, DMPA, DNOC, dodemorph, dodicin, dodine, dofenapyn, doguadine, doramectin {= 2,4-DP), 3,4-DP, DPC, drazoxolon, DSMA, d-trans-allethrin, dymron. EBEP, ecdysone (= etxlysterone), echlomezol, EDB, EDC, EDDP (= edifenphos). eglinazine, emamectin, EMPC, empen-thrin, endosulfan, endothai (= endothall), endoHiion, endrin, ephirsulfonate, EPN, epofenonane, epoxiconazole, eprinomectin, epronaz, EPIC, erbon, esfenvalerate, ESP, esprocarb, etaconazole, etaphos, etem, ethaboxam, ethalfluralin, ethametsulfu-ron, ethidimuron, ethiofencarb, ethiolate. ethion. ethiprole, ethirimol, ethoate-methyl, ethofumesate, ethoprop (= ethoprophos), ethoxyfen, ethoxyquin, ethoxysulfuron. ethyl pyrophosphate, ethylan (= ethy^DDD), ethylene dibromide, ethylene dichloride, ethyl¬ene oxide, ethyl formate, ethylmercury acetate, ethyimercury bromide, ethyfmercury chloride, ethylmercury phosphate, etinofen, ETM, etnipromid, etobenzanid, etofenprox, loxazole, etridiazole, etrimfos, EXD, famoxadone, famphur, fenac, fenamidone, fen-mtnosulf, fenamiphos, fenapanil, fenarimol, fenasulam, fenazaflor, fenazaquin, fenbu-onazole, fenbutatin oxide, fenchiorphos, fenethacarb, fenfluthrin, fenfuram, fen-examid, fenidin, fenitropan, fenitrothion, fenizon, fenobucarb, fenolovo, fenoprop, jnothjocarb, fenoxacrim, fenoxanil, fenoxaprop, fenoxaprop-P, fenoxycarb, fenpiclonil. snpirithrin, fenpropathrin, fenpropidin, fenpropimorph, fenpyroximate. fenridazon, ten¬on, fensuffothion, fenteracol, fenthiaprop, fenthion, fenthion-ethyl, fentiaprop, fentin, sntrazamide, fentrifanil, fenuron, fenvalerate, ferbam, ferimzone, ferrous sulfate, proni], flamprop, flamprop-M, flazasulfuron, flonicamid, florasulam, fluacrypyrim, fluazi-ap, fluazifop-P, fluazinam, fluazolate. fluazuron, flubenzimine, flucarbazone, flu-;hloralin, flucofuron, flucycloxuron, flucythrinate, fludioxonil, fluenetil, flufenacet, flirfen-irim, flufenican, flufenoxuron, flufenprox, flufenpyr, flumethrin, flumetover, ftumetsulam, lumezin, flumiclorac, flumioxazin, flumipropyn, fluometuron, fluorbenside, fluoridannid, luorochloridone, fluorodifen, fluorogfycofen, fluoroimide, fluoromidine, fiuoronrtrofen, luothiuron, fluotrimazole, flupoxam, flupropacil, flupropanate, flupyrsulfuron, fluquin-;onazole, fluridone, flurochloridone, fluromidine, fluroxypyr, flurtamone, flusilazole, lusulfamide, fluthiacet, flutolanil, flutriafol, fluvalinate, tau-fluvalinate, folpel (= folpet), omesafen, fonofos, foramsulfuron, formaldehyde, formetanate, formothion, formparan-jte, fosamine, fosetyl, fosmethilan, fospirate, fosthiazate, fosthietan, fthalide, fuberida-;ole, furalaxyl, furametpyr, furathiocarb, furcarbanil, furconazole, furconazole-cis, fure-:brin, furmecydox, furophanate, furyloxyfen, gamma-BHC, gamma-cyhalothrin, jamma-HCH, glufosinate, glyodin, glyphosate, griseofulvin, guanoctine (= guazatine), lalacrinate, halfenprox, halofenozide, halosafen, halosulfuron, haloxydine, haloxyfop, HCA, HCH, gamma-HCH, HEOD, heptachlor, heptenophos, heterophos, hexachlor (= nexachloran), hexachloroacetone, hexachlorobenzene, hexachlorobutadiene, hex-aconazole, hexaflumuran, hexafJuoramin, hexafltirate, hexazinone, hexylthiofos, hexythlazox, HHDN, hydramethylnon, hydrogen cyanide, hydroprene, hydroxyisoxa-zole, S-hydroxyquinoline sulfate, hymexazol, hyquincarb, IBP, imazalil, imazametha-benz, imazamox, imazapic, imazapyr, imazaquin, imazethapyr, imazosulfuron, Imiben-conazole, imidacloprid, iminoctadine, imiprothrin, indanofan, indoxacarb, iodobonil, iodofenphos, iodosulfuron, ioxynil, ipazine, IPC, ipt»nazole, iprobenfos, iprodione, iprovalicarb, iprymidam, IPSP, IPX, isamidofos, isazofos, isobenzan, isocarbamid, iso-cil, isodrin, isofenphos, isomethiozin, isonoruron, isopolinate, isoprocarb, isoprocil, iso-propalin, isoprothiolane, isoproturon, tsothioate, isouron, isovaledione, isoxaben, isoxa-chlortole, isoxaflutole, isoxapyrifop, isoxathion, isuron, ivemiectin, jasmolin I, jasmoiin II, jodfenphos, juvenile, hormone I, juvenile, hormone II, juvenile, hormone III, karbuti-late, kasugamycin, kelevan, kinoprene, kresoxim-methyt, lactofen, lamtida-cyhalothrin, lead arsenate, \enacH. leptophos, lirn& suifur, d-limonene, lindane, linuron, lirimfos, iu-fenuron, lythidattiion, M-74, M-81, MAA, malathion, maldison, malonoben, MAMA, mancopper, mancozeb, maneb, maadox, MCC, MCPA, MCPA-thioethyi, MCPB, 2,4-MCPB, mebenil, mecarbam, mecarbinad, mecarphon, mecoprop, mecoprop-P, medinoterb, mefenacet, mefluidide, menazon, MEP, mepanipyrim, mephosfolan, me- pronil, mercapfodrmefhur, mercaptophos,Viercaptophos-(eo(ovy, mercaptothion, mer-.curie chloride, mercuric oxide, mercurous chloride, mesoprazine, mesosulfuron, meso-trione, mesulfen, mesulfenfos, mesulphen, metalaxyl, metalaxyl-M, metam, metami-tron, metaphos, metaxon, metazachlor, metazoxolon, metconazoie, metflurazon, meth-abenzthiazuron, methacrifos, methalpropalin, metham, methamidophos, methasulfo-cart), methazole, methfuroxam, methibenzuron, methidathion, methiobencarb, methio-carb, methiuron, methocrotophos, metholcarb, methometon, methomyl, methoprene, methoprotryn, methoprotryne, methoxychlor, 2-methoxyethylmercury chloride, meth-oxyfenozide, methyl bromide, methylchloroform, methyldrthiocarbamic acid, me-thyldymron, methylene chloride, methyl isothiocyanate, methyl-mercaptophos, methyl-mercaptophos oxide, methyl-mercaptophos-teolovy, methyimercury benzoate, methyl-mercury dicyandiamide, methyl parathion, methyltriazothion, metiram, metobenzuron, metobromuron, metolachlor, S-metolachlor, metolcarb, metomlnostrobin, metosulam, metoxadiazone, metoxuron, metrafenone, metribuzin, mefriphonate, metsutfovax, metsutfuron, mevinphos, mexacarbate, mitbemectin, milneb, mipafox, MIPC, mirex, MNAF, molinate, monalide, monisouron, monochloroacetic acid, monocrotophos, monolinuron, monosulfiram, monuron, morfamquat, morphothion, MPMC, MSMA, MTMC, myclobutanil, myclozclin, nabam, naftalofos, naled, naphthalene, naphthalic anhydride, naphthalophos, naproanilide, napropamide, naptalam, natamycin, neburea, neburon, nendnn, nichlorfos, niclofen, niclosamide, nicobifen, nicosuifuron, nicotine, nifluridide, nikkomycins, NIP, nipyraclofen, nitenpyram, nithiazine, nitralin, nitrapyrin, nitrilacarb, nitrofen, nitrofluorfen, nitrostyrene, nitrothal-isopropyl, nobormide, norbor-mide, norea, norflurazon, noruron, novaluron, noviflumuron, NPA, nuarimol, OCH, oc-thilinone, o-dichlorobenzene. ofurace, omethoate, orbencarb, orthobencarb, ortho-dichlorobenzene, oryzalin, ovatron, ovex, oxadiargyl, oxadiazon, oxadixyl. oxamyl, oxapyrazon, oxasulfuron, oxaziclomefone, oxine-copper, oxine-Cu, oxpoconazole, oxy-carboxin, oxydemeton-methyl, oxydeprofos, oxydisulfoton, oxyfluorfen, oxythioquinox, PAC, pallethrine, PAP, para-dichlorobenzene, parafluron. paraquat, parathion, para-thion-methyl, Paris green, PCNB, PCP, p-dichlorobenzene, pebulate, pedinex, pefura-zoate, penconazole, pencycuron, pendimethaiin, penfluron, penoxsulam, pentachloro-phenol, pentanochlor, pentoxazone, perfluidone, permethrin, pethoxamid, PHC, ph6-netacartie, phenisopham, phenkapton, phenmedipham, phenmedipham-ethyl, pheno-benzuron, phenothiol, phenothrin, phenthoate, phenylmercunurea, phenylmercury ace¬tate, phenylmercury chloride, phenylmercury nitrate, phenylmercury salicylate, 2-phenylphenol, phorate, phosalone, phosdiphen. phosfolan, phosmet, phosnichlcr, phosphamide, phosphamidon, phosphine, phosphocarb. phoxim, phoxim-methyl, phthalide, phthalophos, phthalthrin, picloram, picolinafen, picoxystrobin, piperophos, pirimetaphos, pirimicaria, pirimifrfios-ethyl, pirimiphos-methyl, PMA, PMP, poiycar-bamate, polychlorcamphene, polyethoxyquinoline, polyoxins, polyoxorim, potassium arsenite, potassium cyanate, potassium polysulfide, potassium thiocyanate, prallethrin, precocene I, precocene II, precocene III, pretilachlor, primidophos, primisulfuron, pro-benazole, prochloraz, proclonol, procyazine, procymidone, prodiamine, profenofos, profluazol, profiuralin, profoxydim, proglinazine, promacyl, promecarb, prometon, pro-metryn, prometryne. pronamide, propachlor, propafos, propamocarb, propanil, propaphos, propaquizafop, propargite, propazine, propetamphos, propham, propicona-zole, propineb, propisochlor, propoxur, propoxycarbazone, propyzamide, prosuifalin, prosulfocarb, prosuifuron, prothidathion, prothiocarb, prothiofos, prothoate, protrifen-bute, proxan, prymidophos, prynachlor, pydanon, pyracarbolid, pyraclofos, pyraclonil, pyraclostrobin, pyraflufen, pyrazolate, pyrazolynate, pyrazon, pyrazophos, pyrazosulfu-ron, pyrazoxyfen, pyresmethrin, pyrethrin I, pyrethrin II, pyrethrins, pyribenzoxim, py-ributicarb, pynclor, pyridaben, pyndafol, pyndaphenthion, pyridate, pyridinitril, pyrifenox, pyriftalid, pyrimetaphos, pyrimettianil, pyrimicarbe, pyrimidifen, pyrimitate, pyriminobac, pyrimiphos-ethyl, pyrimiphos-methyl, pyriproxyfen, pyrithiobac. pyroquilon, pyroxychlor, pyroxyfur, quassia, quinacetol, quinalphos, quinalphos-methyl, quinazamid, quinclorac, quinconazoie, quinmerac, quinoclamine, quinomethionate, quinonamid, quinothion, quinoxyfen, quintiofos, quintozene, quizalofop, quizalofop-P, rabenzazole, rafoxanide, reglone, resmethrin, rhodethanil, rimsulfuron, rodettianil, ronnel, rotenone, ryania, sa-badilla, salicylanilide, schradan, sebuthylazine, secbumeton, selamectin, sesone, seth-oxydim, sevin, siduron, silafluofen, silthiofam, silvex, simazine, simeconazole, simeton, simetryn, simetryne, SMA, sodium arsenite, sodium chlorate, sodium fluoride, sodium hexafluorosilicate, sodium orthophenylphenoxide, sodium pentachlorophenate, sodium pentachlorophenoxide, sodium o-phenylphenoxide, sodium polysulfide, sodium sill-cofluoride, disodium tetraborate, sodium thiocyanate, solan, sophamide, spinosad, spi-rodlclofen, spiroxamine, stirofos, streptomycin, sulcofuron, sulcotrione, sulfallate, sulf-entrazone, sulfiram, sulfluramid, sulfometuron, sulfosulfuron, sulfotep, sulfotepp, sulfur, sulfuric acid, sulfuryl fluoride, sulglycapin, sutprofos, sultropen, swep, 2,4,5-T, tau-fluvalinate, tazimcarb, 2,4,5-TB, 2,3,6-TBA. TBTO, TBZ, TCA, TCBA. TCMTB, TCNB, TDE, tebuconazole, tebufenozide, tebufenpyrad, tebupirimfos, tebutam, tebuthiuron, tecloftalam, tecnazene, tecoram, tedion, teflubenzuron, tefluthrin, temephos, TEPP, tepraloxydtm, terallethrin, terbacil, terbucarb, terbuchlor, terbufos, terbumeton, ter-buthylazine, tertDutot, terbutryn, terbutryne, terraclor, tetrachloroethane, tetrachlorvin-phos, tetraconazole, tetradifon, tetradisul, tetrafluron, tetramethrin, tetranactin, tetrasul, thenylchlor, theta-cypemiethrin, thiabendazole, thiacloprid, thiadiazine, thiadifluor, thiamethoxam, thiameturon, thiazafiuron, thiazone, thiazopyr, thicrofos, thicyofen, thidi-azimin, thidiazuron, thifensulfuron, thifluzamide, thiobencarb, thiocarboxime, thiochlor-fenphim, thiochlorphenphime, thiocyclam, thiodan, ttitodicarb, thiofanocarb, thiofanox, thiomersal, thiometon, thionazin, thiophanate, thiophanate-ethyl, thiophanate-methyl, thiophos, thioquinox, thiosultap, thiram, thiuram, thuringiensin, tiabendazole, tiocarba-zil, tioclorim, tioxymid, TMTD, tolclofos-methyl, tolylfluanid, tolfenpyrad, totylmercury acetate, toxaphene, 2,4,5-TP, 2,3,3-TPA, TPN, tralkoxydim, tralomethrin, d-trans-allethrin, transfluthrin, transpermethrin, tri-atlate, triadimefon, triadimenol, triallate, triamiphos, triarathene, triarimol, triasutfuron, triazamate, triazbutil, triaziflam, triazo-phos, triazothion, triazoxide, tribenuron. tributyltin oxide, tricamba, trichlamide, trichlor-fon, trichlonnetaphos-3, trichloronat, trichloronate, tfchlorphon, triclopyr, tricyclazole, tricyclohexyltin hydroxide, tndemorph, tridiphane, tnetazine, tnfenofos, trifloxystrobin, trifloxysulfuron, triflumizoie, triflumuron, trifluraiin, triflusulfuron, trifop, trifopsime, tri-forine, trimeturon, triphenyltin, triprene, tripropindan, tritac, triticonazole, tritosulfuron, uniconazole, uniconazole-P, validamycin, vamidothion, vaniliprole, vernolate, vinclo-zolin, XMC, xylachlor, xylenols, xylylcarb, zanlamid, zeta-cypermethrin, zinc naphthen-ate, zineb, zolaprofos, zoxamide trichlorophenate, 1,2-dichloropropane, 1,3-dic^loropropene, 2-methoxyethylmercury chloride, 2-phenylphenol, 2,3,3-TPA, 2,3,6-TBA, 2,4-D, 2,4-DB, 2,4-DEB. 2,4-DEP, 2,4-DP, 2.4-MCPB. 2,4.5-T, 2,4,5-TB, 2,4,5-TP, 3,4-DA, 3,4-DB, 3,4-DP, 4-CPA, 4-CPB, 4-CPP, 8-hydroxyquinoline sulfate. Particulariy preferred plant protection active compounds are fungicides, such as, for example: • acylalanines, such as benalaxyl, metalaxyl, ofurace oroxadixyl, • amine derivatives, such as aldimorph, dodine, dodemorph, fenpropimorph, fen-propidin, guazatine, iminoctadine, spiroxamine or tndemorph, • anilinopyrimidines, such as pyrimethanil, mepanipyrim or cyprodinil, • antibiotics, such as cycloheximide, griseofulvin, kasugamycin, natamycin, polyoxin or streptomycin, • azoles, such as bitertanol, bromoconazole, cyproconazole, difenoconazole, dini-conazole, epoxiconazole, fenbuconazole, fluquinconazole, flusilazole, hexacona-zole, imazalil, metconazole, myclobutanil, penconazole, propiconazole, prochloraz, prothioconazole, tebuconazole, triadimefon, triadimenol, triflumizoie or triticonazole, • dicarboximides, such as iprodione, myclozolin, procymidone or vinclozolin, • dithiocarbamates, such as ferbam, nabam, maneb, mancozeb, metam, metiram, propineb, polycarbamate, thiram, ziram or zineb, • heterocyclic compounds, such as anilazine, benomyl, boscalid, carbendazim, car-boxin, oxycarboxin, cyazofamid, dazomet, dithianon, famoxadone, fenamidone, fenarimol, fuberidazole, flutolanil, furametpyr, isoprofriiolane, mepronil. nuarimol, probenazole, proquinazid, pyrifenox, pyroquilon, quinoxyfen, siithiofam, thiabenda¬zole, thifluzamide, thiophanate-methyl, tiadinil, tricyclazole ortriforine, • copper fungicides, such as Bordeaux mixture, copper acetate, copper oxychloride or basic copper sulfate, • nitrophenyl derivatives, such as binapacryl, dtnocap, dinobuton or nitrothal-isopropyl, • phenylpyrroles, such as fenpiclonil or fludioxonil, • sulfur, • other fungicides, such as acibenzolar-S-methyl, benthiavalicartj, carpropamid, chlorothalonil, cyflufenamid, cymoxanil, dazomet, diciome^ne, diclocynriet. diefriofencarb, edifenphos, ethaboxam, fenhexamid, fentin acetate, fenoxanil, ferimzone, fluazinam, fosetyl, fosetyi-aluminum, iprovalicarb, hexachlorobenzene, metrafenone, pencycuron, propamocarb, phthalide, tolclofos-methyl, qulntozene or zoxamide, • sulfenic acid derivatives, such as captafol, captan, dichlofluanid, folpet or tolylftua-nid, • cinnamamides and analogous compounds, such as dimethomorph, flumetover or flumorph. Very particularly preferred are the strobilurins, such as azoxystrobin, dimoxystrobin, fluoxastrobin, kresoxim-methyl, metominostrobin, orysastrobin, picoxystrobin, pyraclos-trabin ortrifloxystrobin, in particular pyraclostrobin. In the formulations according to the invention, several plant protection active com¬pounds - also of a different indication - can be present simultaneously. A prefen-ed plant protection formulation comprises, as component a), at least one plant protection active compound selected from the class of the fungicides. Particulariy prefered are active compound formulations in w/hich the at least one active compound is selected from the group of the strobilurins; pyraclostrobin is particularly preferred. Furthermore, particular preference is given to active compound fonnulations compris¬ing, as active compound, mixtures of pyraclostrobin with additional plant protection active compounds. Such mixing partners are • acylalanines, such as benalaxyl, metalaxyl, ofurace oroxadixyl, • amine derivatives, such as aldimorph, dodine, dodemorph, fenpropimorph, fen-propidin, guazatine, iminoctadine, spiroxamine ortridemorph, • anilinopyrimidines, such as pyrimethanil, mepanipyrim or cyprodinil, • antibiotics, such as cycloheximide, griseofulvin, kasugamycin, natamycin, polyoxin or streptomycin, • azoles, such as bitertanol, bromoconazole, cyproconazole, difenoconazole, dini-conazole. epoxiconazole, fenbuconazole, fluquinconazole, flusilazole, hexacona-zole, imazalil, metconazole, myclobutanil, penconazole, propiconazole, prochloraz, prothioconazole, tebuconazole, triadimefon, triadimenol, triflumizole or triticonazole. • dicartxjximfdes, such as iprodione, myclozolin, procymidone or vinclozolin, • dithiocarbamates, such as ferbam, nabam, maneb, mancozeb, metam, metiram, propineb, polycartjamate, thiram, ziram or zineb, • heterocyclic compounds, such as anilazine, benomyl, boscalid, cart)endazim, car-txiwn, oxycartwwn, cyazofamld. dazomet, dithianon, famoxadone, fenamidone, fenarimol, fuberidazole, flutolanil, furametpyr, isoprothiolane, mepronit, nuarimol. probenazoie, proquinazid, pyrifenox, pyroquilon, quinoxyfen, siithiofam, thiabenda¬zole, thifluzamide, thiophanate-methyl, tiadinil, tricyclazole or triforine, • copper fungicides, such as Bordeaux mixture, copper acetate, copper oxychloride or basic copper sulfate, • nitrophenyl derivatives, such as binapacryl, dinocap, dinobuton or nitrotlial-isopropyl, • phenylpyrroles, such as fenpiclonil or fludioxonil, • sulfur, • other fungicides, such as acibenzolar-S-methyl, benthiavalicarb, carpropamid, chlorothalonil, cyflufenamid, cymoxanil, dazomet, diclomezine, diclocymet, diethofencarb, edifenphos, ethaboxam, fenhexamid, fentin acetate, fenoxanil, ferimzone, fluazinam, fosetyl. fosetyl-aluminum, iprovalicarb, hexachlorobenzene, metrafenone, pencycuron, propamocarb, phttialide, tolclofos-metliyl, quintozene or zoxamjde, • sulfenic acid derivatives, such as captafol, captan, dichlofluanid, folpet or tolytflua-nid, • cinnamamides and analogous compounds, such as dimethomorph, flumetover or flumorph. Prefen-ed mixing partners are metalaxyl, dodemorph, fenpropimorph, fenpropidin, guazatine, spiroxamine, tridemorph, pyrimethanil, cyprodinil, bitertanol, bromocona-zole, cyproconazole, difenoconazole, diniconazole, epoxiconazole, fenbuconazole, fluquinconazole, flusilazole, tiexaconazole, imazalii, metconazole, myclobutanil, pen-conazote, propiconazole, prochloraz, prothioconazole, tebuconazole, triadimefon, tri-adimenol, triflumizole, triticonazole, iprodione, vindozolin, maneb, mancozeb, metiram. thiram, boscalid, carbendazim, cartsoxin, oxycarboxin, cyazofamid, dithianon, fa-moxadone, fenamidone, fenarimol, flutolanil, quinoxyfen, thiophanate-methyl, triforine, dinocap, nitrothal-isopropyl, phenylpyrroles, such as fenpiclonil or fludioxonil, aciben¬zolar-S-methyl, t>enthiavaiicarb, carpropamid, chlorothalonil, cyflufenamid, cymoxanil, fenhexamid, fentin acetate, fenoxanil, fluazinam, fosetyl, fosetyl-aluminum, iprovalicarb, metrafenone, zoxamide, captan, folpet, dimethomorph,azoxystrobin, dimoxystrobin, fluoxastrobin, kresoxim-methyi, metominostrobin, orysastrobin, picoxystrobin or trifloxystrobin. Particularly preferred mixing partners are metalaxyl, fenpropimorph, fenpropidin, guazatine, spiroxamine, pyrimethanil, cyprodinil, cyproconazole, difenoconazole. ep¬oxiconazole, fenbuconazole, fluquinconazole, flusilazole, hexaconazole, metconazole, myclobutanil, propiconazole, prochloraz, prothioconazole, tebuconazole, triticonazole, iprodione. vindozolin, boscalid, carbendazim, carbojdn, oxycarbown, cyazofamid, di¬thianon, quinoxyfen, thiophanate-metfiyl, dinocap, nitrothal-isopropyl, fenpidonil or fludioxonil, t>enthiavaficarb, carpropamid, fenhexamid, fenoxanil, fluazinam, tprovali-cartj, metrafenone, zoxamide, dimethomorph, azoxystrobin, dimoxystrobin, fluoxa- strobin, kresoxim-methyl, metominostrobin, orysastrobin, picoxystrobin ortrifloxy-strobin. Very particularly preferred mixing partners are fenpropimorph, cyproconazole, difeno-conazole, epoxiconazole, fenbuconazole, fluquinconazole, flusilazole, hexaconazo\e, metconazole, myclobutanil, propiconazole, prochloraz, prothioconazole, tebuconazole, triticonazole, boscalid, dithianon, quinoxyfen, thiophanate-methyi, dinocap, fenpiclonil or fludioxonil, benthiavalicarb, carpropamid, fenhexamid. fenoxanil, fluazinam, iprovali-carb, metrafenone, zoxamide, dimethomorph, azoxystrobin, dimoxystrobin, fluoxa-strobin, kresoxim-methyl, metominostrobin, orysastrobin, picoxystrobin ortrifloxy-strobin. The active compound fonnulations according to the invention can comprise different amounts and types of additives, such as, for example, solvents. Thus, solvents can be used, for example, for the preparation of the random radical polymers and of the active compound formulations according to the invention. In an additional embodiment of the invention, the active compound formulations according to the invention can also be present in the form of a fluid solution. Suitable solvents are alcohols, such as, e.g., methanol, ethanol or isopropanol, dipolar aprotic solvents, such as, e.g., DMF, DMSO or NMP, or aromatic, aliphatic, halogenated or nonhalogenated hydrocarbons, such as, e.g., hexane, chlorobenzene, toluene or benzene. Depending on the kind of formulation desired, the solvents can, however, also be removed to the greatest possible extent. Removed to the greatest possible extent means that the proportion of the solvent re¬maining in the formulation to the total weight of the fomiulation is less than 10, prefera¬bly less than 2 and in particular less than 0.5 percent by weight. The invention accordingly also relates to active compound formulations in a dried and solid form, i.e. a form freed to the greatest possible extent from the solvent. The solid active compound fonnulations can exist in different macroscopic fonms. Men¬tion may be made, as examples of macroscopic forms, of spray-dried powder, ground product, granules or film. The random radical copolymers present in the active compound formulation according to the invention are suitable for dispersing in aqueous systems, in the form oi nanopar¬ticulate dispersions, the active compound(s) present in ttie active compound formula¬tion according to the invention. Such nanoparticulate dispersions comprise at least one continuous phase, which is an aqueous system in the present invention, and at least one dispersed phase. The nanoparticulate dispersions can comprise additional addi¬tives. For this reason, the present invention likewise relates to aqueous dispersions compris¬ing the active compound formulations according to the invention, an aqueous system and if appropriate additional additives. Such additives are dispersants, thiciceners, antifoam agents, bactericides and anti¬freeze agents. Aqueous system is understood as meaning pure water or vrater comprising a buffer system or salts or additional additives, such as, for example, water-miscible solvents or mixtures thereof. The pH of the aqueous system generally ranges from 2 to 13, preferably from 3 to 12, particularly preferably from 4 to 10. The invention also relates to processes for the preparation of aqueous dispersions comprising the active compound fonnulations according to tiie invention and optionally additional additives, wherein the active compound formulations according to the inven¬tion are brought into contact with an aqueous system and conventionally dispersed. An important property of the dispersions according to the invention is the mean particle size, determined by quasielastic light scattering, of the dispersed particles, which is, according to the invention, less than 1 micrometer, preferably less than 500 nanome¬ters, particularly preferably less than 100 nanometers. In this connection, particle size is understood as meaning the particle diameter detemiined by means of quasielastic light scattering. The method of quasielastic light scattering by means of fiber optics is knovm from the state of the art, for example from H. Auweter, D. Horn, J. Colloid Interf. Sci, 105 (1985). 399, D. Lilge. D. Horn, Colloid Polym. Sci.. 269 (1991). 704, or H. l^ese, D. Horn. J. Chem. Phys.. 94 (1991), 6429. Anionic and nonionic surtactants are used as dispersants. Anionic surtactants are alkylarytsutfonates, phenytsulfonates, alkyl sulfates, alkylsul-fonates, alkyi ether sulfates, alkylaryl ether sulfates, alkyl polyglycol ether phosphates, polyarylphenyl ether phosphates, alkyl sulfosuccinates, olefin sulfonates, paraffin sul¬fonates, petroleum sulfonates, taurides, sarcosides, fatty acids, alkylnaphthalenesulfo-nic acids, naphthalenesutfonic acids, lignosulfonic acids, condensation products of sul¬fonated naphthalenes vflth formaldehyde or with formaldehyde and phenol and if ap¬propriate urea, and condensation products from phenolsutfonic acid, formaldehyde and urea, lignin sulfite waste liquors and lignosulfonates, inclusive of their alkali metal, alka¬line earth metal, ammonium and amine salts, alkyl phosphates and polycarboxylates, such as, e.g., potyacrylates, maleic anhydride/olefin copolymers (e.g., Sokalan* CP9, BASF). Nonionic surfactants, are, for example, alkylphenol alkoxylates, alcohol alkoxylates, fatty amine alkoxylates, potyoxyethylene glycerol fatty ackJ esters, castor oil alkoxy¬lates, ^tty acid alkoxylates, fatty acid amide alkoxylates, fatty add polydiethanola-mides, lanolin ethoxylates, fatty acid polyglycol esters, isotridecyl alcohol, fatty acid amides, methylcellulose, fatty acid esters, silicone oils, alkyipolyglycosides, glycerol fatty acid esters, polyethylene glycol, polypropylene glycol, polyethylene glycol-"polypropylene glycol block copolymers, polyethylene glycol alkyi ethers, polypropylene glycol alkyi ethers, polyethylene glycol/poiypropylene glycol ether block copolymers 3nd their mixtures. Preferred nonionic surfactants are polyethylene glycol/poiypropylene glycol block co-Dolymers; polyethylene glycol alkyi ethers, polypropylene glycol alkyi ethers, polyethyl-sne glycol/poiypropylene glycol ether block copolymers and their mixtures, If appropriate, surfactants are used as additives in the dispersion according to the in->"ention comprising the active compound formulation and an aqueous system. Suitable surfactants are anionic surfactants and nonionic surfactants; mixftjres of both are pre¬ferred. The viscosity-modifying additives (thickeners) suitable for the dispersions according to the invention are compounds v*4iich confer a pseudoplastic flowf behavior on the formu¬lation, i.e. high viscosity at rest and low viscosity in the agitated state. Mention may be made, in this connection, for example, of polysaccharides or organic layered minerals, such as Xanthan Gum* {Kelzan* from Keico), Rhodopol® 23 (Rhone-Poulenc) or Veegum* (R.T. Vanderbilt), or Attaclay® (Engelhardt), XanthanGum® preferably being used. Silicone emulsions (such as, e.g., Silicone® SRE, Wacker, or Rhodorsit® from Rhodia), long-chain alcohols, fatty acids, fluoroorganic compounds and their mixtures, for exam¬ple, come into consideration as anftfoam agents suitable for the dispersions according to the invention. Bactericides can be added to stabilize the dispersions according to the invention. Suit¬able bactericides are, for example, Proxel® from ICI or Acticide® RS from Thor Chemie and Kathon* MK from R6hm & Haas. Suitable antifreeze agents are, e.g., ethylene glycol, propylene glycerol or glycerol. If appropriate, the dispersions according to ttie invention can, to regulate the pH, com¬prise 1 -5% by weight of buffer based on the total amount of the formulation prepared, the amount and type of the buffer used depending on ttie chemical properties of the active compound or compounds. Examples of buffers are alkali metal salts of weak inorganic or organic adds, such as, e.g., phosphoric acid, boric acid, acetic acid, propi¬onic acid, citric acid, fumaric acid, tartaric acid, oxalic add and succinic acid. The invention furthemiore relates to processes for tiie preparation of the active com¬pound formulations according to the invention, which comprise dissolving the at least one active compound and the at least one random radical copolymer, separately from one another, in identical or different organic solvents which are preferably miscible wnth one another and mixing the solutions thus obtained with one another and optionally adding additives or preparing a combined solution, by presenting the at least one active compound dis¬solved in an organic solvent and adding the at least one random radical copolymer and optionally additional additives and dissolving, and subsequently removing the solvent or solvents in a conventional vray to the greatest possible e)ctent. Conventional processes for removing solvents are, for example, spray drying, evapora¬tion under reduced pressure, freeze drying, or evaporation at atmospheric pressure and, if appropriate, increased temperature. The processes suitable for drying further¬more include lyophilization or drying in a fluidized bed dryer. The active compound for¬mulations according to the invention are accordingly obtained in a dried form. If the copolymer necessary for the synthesis is already present in a solvent, this solu¬tion is preferably enlisted in the mixing with the active compound or active compound solution. In a first step, separate solutions of the at least one random radical copolymer and of the at least one active compound in identical or in different solvents are accordingly mixed with one another and additional additives are optionally added. The preparation of a solution of the polymer does not apply if the synthesis of the polymer is carried out in a solvent and this solution is suitable for use in the process for the preparation of the formulation according to the invention. In this second step, the solvent(s) is/are removed by suitable processes in a conven¬tional way to the greatest possible extent The invention furtbemiore relates to processes for the preparation of the active com¬pound fomiulation according to the invention, which comprise forming an aqueous so¬lution of the at least one random radical copolymer (component b)), dissolving the at teast one active compound ((xjmponent a)) in on& or more water-miscible organic sol¬vents, mixing the solutions of the components a) and b) with one another, optionally adding additional additives, obtaining the active compound formulation in dispersed form by introduction of shear forces and subsequently removing Sie solvente in a corv ventional vray to the greatest possible extent. L. Water-miscible means in this connection that the organic solvents are miscible with water without phase separation to at least 10% by weight, preferably to 15% by weight, particularly preferably to 20% by weight. Should an aqueous solution of the copolymer necessary for this synthesis already ex¬ist, this aqueous solution is preferably enlisted in the mixing with the active compound solution. In a first step, the random radical copolymer(s) and if appropriate additional additives are dissolved in an aqueous system, if such an aqueous solution is not already directly obtained from the step of the polymer synthesis. In addition, the active compound or compounds is/are dissolved in a water-miscible solvent if appropriate with addition of additional additives. The two solutions are then mixed with one another. Provision of energy is advantageous for the preservation of fine particles on mixing the aqueous and organic phases, such as, for example, the application of shear forces, by high-frequency and high-amplitude shaking or high-frequency stinging, turbine agitation, or by use of a mixing chamber. The mixing can be earned o,ut in a continuous or batchwise fashion. Continuous mixing is preferred. The dispersion obtained in this way can be freed from the solvents in a conventional way as explained above. Suitable solvents for carrying out the processes for the preparation of a active com¬pound formulation according to the invention are Ci-Ce-alkyl alcohols, such as metha¬nol, ethanol, propanol, isopropanol, 1-butanol, 2-butanol ortert-butanoi, esters, ke¬tones, such as acetone, methyl ethyl ketone, methyl isopropyl ketone or methyl isobuty! ketone, acetals, ethers, cyclic ethers, such as tetrahydrofuran, aliphatic carboxylic ac¬ids, such as formic acid, acetic acid or propionic acid, N-substituted or N,N-disubstituted carboxamides, such as acetamide, cartiox^ates, such as, for example, acetates and lactones, such as, for example, butyrolactone, dimethylformamide (DMF) and dimethylpropionamide, aliphatic and aromatic chlorinated hydrocarbons, such as methylene chloride, chlorofomi, 1,2-dichloroethane or chlorobenzene, N-lactams, and mixtures of the abovementioned solvents. Prefen-ed solvents are methanol, ethanol, isopropanol, dimethylfomnamide, N-methylpyrrotidone, methylene chloride, chlorofomi, 1,2-dichloroethane, chlorobenzene, acetone, methyl ethyl ketone, methyl isopropyl ketone, meth^ isobutyl ketone, tetrahy¬drofuran, and mixtures of the abovementioned solvents. Particularly preferred solvents are methanol, ethanol, isopropanol, dimethylformamide and tetrahydrofuran. Appropriate solids contents of the solutions lie in the concentration range from 0.5 to 30 percent by weight {% by weight), preferably between 1 and 20% by weight. The active compound formulations according to the invention exist, after removal of the so!vent(s), in a dried state. Naturally, the active compound formulations according to the invention can also exist in the form of suspoemulsions or emulsifiable concentrates with the use of conventional additives and methods known to a person skilled in the art The active compound fomnulations can according to the invention comprise additives. Such suitable additives are knovm to a person skilled in the art. They can be inert auxil¬iaries, such as oils of different origins (mineral oils, coaMar oils, animal and plant oils), aliphatic and aromatic hydrocarbons, such as alkylated naphthalenes, alcohols, such as methanol, ethanol, butanol or cyclohexanol, ketones, such as cyclohexanone, polar solvents and amines, such as N-methylpyrrotidone. Preferred additives are stabilizers and plasticizers. Suitable stabilizers can be low-molecular weight components, such as, for example, mono- and diglycerides, esters of the monoglycerides, alkylglucosides, lecithin, fatty acid derivatives of urea and urethanes. Suitable plasticizers are sucrose, glucose, lactose, fructose, sorbitol, mannitol or glyc¬erol. The invention additionally relates to active compound formulations comprising pyra-clostrobin, wherein the average particle diameter, determined by quasielastic light scat¬tering, is less than 1 micrometer, preferably less than 300 nanometers and particularly preferably less than 100 nanometers. The following examples illustrate the invention writhout, however, thereby limiting it Example 1: 2-Acrylamido-2-methyi-1 -propanesutfonic acid-co-phenoxyethyt acrylate-co-n-butyl acrylate (weight ratio 17/33/50) 13.6 g of phenoxyethyl acrylate, 26.4 g of n-butyl acrylate, 40 g of 2-acrytam!do-2-methylpropanesutfonic acid and 2.4 g of Wako V60 (azobisisobutyronitrile) were dis¬solved in 712 g of dimethytformamide (DMF). The vessel was exposed to nitrogen gas and heated to QSX. After stirring for 4 hours, 0.8 g of Wako V60 in 7.2 g of DMF was added and the mixture was stirred for a further 2 hours. bxampie z: 2-Acrylamido-2-methyl-1-propanesulfonic acid-co-n-butyl acrylate (weight ratio 50/50) 40 g of n-butyl acrylate, 40 g of 2-acryiamido-2-methylpropanesulfonic acid and 2.4 g of Wako V60 (azobisisobutyronitrile) were dissolved in 712 g of DMF. The vessel vi/as exposed to nitrogen gas and heated to 95""C. After stirring for 4 hours, 0.8 g of Wako V60 in 7.2 g of DMF was added and the mirfure was stirred for a further 2 hours. Example 3: Particle sizes of nanoparticulate dispersions of active compound formulations with dif¬ferent polymers and different polymer/active compound ratios determined using quasi-elastic light scattering. Measurements were carried out after 2 hours and after 24 hours. AMPS: 2-Acrylamido-2-methyl-1-propanesulfonicacid PEA: Phenoxyethyl acrylate n-BA n-Butyl acrylate The proportions by weight of the monomers used are indicated, for example, by the numerical sequence 50/17/33, so that AMPS/PEA/n-BA 50/17/33 is to be read as a polymer formed from the monomers 2-acrylamido-2-methyl-1-propanesulfonic acid, phenoxyethyl acrylate and n-butyl acrylate in the weight ratio 50 to 17 to 33. Example 4: Molar weights of the random radical copolymers The molar weights of the polymers were determined using size exclusion chromatogra¬phy. Poly(methyl methacrylate) calibrated test pieces were used as calibration system. Table 2: Example 5; Fungicidal effect of different fomnulatlons according to the invention of pyradostrubin according to the concentration of active compound applied. The character of the dam¬age was determined on wheats of the Kanzler variety which had been infected before¬hand with a fungus of the species Puccinia recondita. The "Active compound formulation" column shows the qualitative and quantitative composition of the respective random radical copolymer present with the active com¬pound in the formulation. The vreight ratio of polymer to active compound was 2 to 1 for all formulations. The "Concentration" column gives the concentration at whidi the active compound formulation wras applied. The "Rating" column gives, on a scale from 0 to 100, the fungal infection remaining after the treatment, the figure 100 denoting completely infected. The stated value is a mean value of three individual values. AMPS: 2-acrylamido-2-methyl-1-propanesulfonic add MA, EA, BA, PEA: methyl, ethyl, butyl, phenoxyethyl acrylate WE CLAIM: 1. An active compound formulation comprising a) at least one plant protective active compound b) at least one random radical copolymer formed from the monomers i), ii) and optionally additional monomers, in which i) is at least one olefmically unsaturated sulfonic add of the formula I ii) is at least one olefmically unsaturated monomer of the formula II c) coptionally additional additives, obtainable by a process, characterized in that (i) the components a) and b) and if appropriate c), and optionally additional additives, are dissolved separately from one another, in identical or different organic solvents and the solutions are mixed with one another and optionally subsequently the solvent is removed in a conventional way to the greatest possible extent; or (ii) a combined solution of the components a) and b) and if appropriate c), and optionally additional additives, is prepared by presenting one of the components dissolved in an organic solvent, adding the additional components and dissolving, and optionally subsequently the solvent is removed in a conventional way to the greatest possible extent; or (iii) an aqueous solution of the component b) is formed, and optionally additional additives, the components a) and, if appropriate, c) and optionally additional additives are dissolved, in one or more water-miscible organic solvents, the solutions of the components are mixed with one another and the active compound formulation is obtained in dispersed form by introduction of energy, and optionally subsequently the solvents are removed in the conventional way to the greatest possible extent. 2. The active compound formulation as claimed in claim 1, wherein the at least one random radical copolymer is formed from i) at least one olefinically unsaturated sulfonic acid of the formula I according to claim 1 or salts thereof or mixtures of acid and salts, ii) phenoxyethyl acrylate, iii) optionally additional olefinically unsaturated monomers of the formula lib 4. The active compound formulation as claimed in claims 1 to 3, wherein the at least one random radical copolymer is formed from i) 2-acrylamido-2-methyl-l-propanesu[fonic acid or salts thereof or a mixture of acid and salt thereof ii) phenoxyethyl acrylate iii) at least one olefmically unsaturated monomer of the formula lie 5. The active compound formulation as claimed in claims 1 to 4, wherein the at least one random radical copolymer is formed from i) 2-acrylamido-2-methyl-l-propanesuWonic acid or salts thereof or a mixture of acid and salt, and ii) phenoxyethyl acrylate. 6. The active compoimd formulation as claimed in claims 1 to 5, wherein the proportion of the sulfonic acid or of a salt or of a mixture of acid and salt in the total weight of the copolymer is 10 to 90 percent by weight. 7. The active compound formulation as claimed in claims I to 6, wherein the ratio of the proportion by weight of component a) to the proportion by weight of component b) ranges from l:10to 10:1. 8. The active compound formulation as claimed in claims 1 to 7. wherein the ratio of the proportion by weight of component a) to the proportion by weight of corn ponent b) ranges from 1:4 to 4:1. 9. The active compound formulation as claimed in claims 1 to 8, wherein the ratio of the proportion by weight of component a) to the proportion by weight of component b) ranges from 1:2 to 2:1. 10. The active compound formulation as claimed in claims 1 to 9, wherein the at least one active compound is chosen from the group of the strobilurins. 11. The active compound formulation as claimed in claim 10, wherein the at least one active compound is pyraclostrobin. 12. The active compound formulation as claimed in claims 1 to 11, in solid form. 13. The active compound formulation as claimed in claims 1 to 11, in the form of a fluid solution comprising, if appropriate, additional additives. 14. The active compound formulation as claimed in claims 1 to 11, in the form of an aqueous dispersion comprising, if appropriate, additional additives. 15. The active compound formulation as claimed in claim 14, wherein the average particle diameter, determined by quasielastic light scattering, is less than 1 micrometer. 16. The active compound formulation as claimed in claim 14 or 15, wherein the average particle diameter, determined by quasielastic light scattering, is less than 300 nanometers. 17. The active compound formulation as claimed in claims 14 to 16, wherein the average particle diameter, determined by quasielastic light scattering, is less than 100 nanometers. 18. The active compound formulation as claimed in claims 14 to 16, wherein the active compound is pyraclosffobin. 19. A process for the preparation of aqueous dispersions, which comprises bringing The active compound formulation as claimed in claims 1 to 18, if appropriate with addition of one or more additives, into contact with an aqueous system and conventionally dispersing. 20. A process for combating harmful fungi, which comprises treating the harmful fungi or their habitat, or treating the plants, surfaces, materials or spaces to be kept free from the harmul fungi with an effective amount of a formulation according to claims 1 to 18. Dated this 30 day of May 2006

Documents:

1896-chenp-2006 abstarct duplicate.pdf

1896-chenp-2006 abstarct.pdf

1896-chenp-2006 claims duplicate.pdf

1896-chenp-2006 claims.pdf

1896-chenp-2006 correspondence others.pdf

1896-chenp-2006 correspondence po.pdf

1896-chenp-2006 description (complete) duplicate.pdf

1896-chenp-2006 description (complete).pdf

1896-chenp-2006 form-1.pdf

1896-chenp-2006 form-18.pdf

1896-chenp-2006 form-26.pdf

1896-chenp-2006 form-3.pdf

1896-chenp-2006 form-5.pdf

1896-chenp-2006 pct.pdf

1896-chenp-2006 petition.pdf