Indian Patents
Title of Invention

BENZOAZOLYPIPERAZINE DERIVATIVES OF FORMULA I
Abstract A.compound of formula (I) wherein ArI, A, R3, x, and m are as disclosed herein and Ar2 is a benzothiazolyl, benzooxazolyl, or benzoimidazolyl group or a pharmaceutically acceptable salt thereof (a "Benzoazolylpiperazine Compound"), compositions comprising a Benzoazolylpiperazine Compound, and methods for treating or preventing pain, VI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease. parki~sonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, retricted brain function, Huntington's chorea., amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective Benzoazolylpiperazine Compound are disclosed.
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living in long-term care institutions (R.M. Resnick, Lancet 346:94 (1995)). Persons having UI are predisposed to also having urinary-tract infections, pressure ulcers, perineal rashes and urosepsis. Psychosocially, UI is associated with embarrassment, social stigmatization, depression and a risk of institutionalization (Herzo et al, Annu. Rev. Gerontol. Geriatw 9:74 (1989)). Economically, the costs of UI are great; in the United States alone, health-care costs associated with UI are over $15 billion per annum.
Physiologic bladder contraction results in large part from acetylcholine-induced stimulation of post-ganglionic muscarinic-receptor sites on bladder smooth muscle. Treatments for UI include the administration of drugs having bladder-relaxant properties, which help to control bladder-detrusor-muscle overactivity. For example, anticholinergics such as propantheline bromide and glycopyrrolate, and combinations of smooth-muscle relaxants such as a combination of racemic oxybutynin and dicyclomine or an anticholinergic, have been used to treat UI {See, e.g., AJ. Wein, Urol Clin. N. Am. 22:557-577 (1995); Levin et al.9J. Urol. 128:396-398 (1982); Cooke et al., S. Afr. Med. J. 63:3 (1983); R.K. Mirakhur et al, Anaesthesia 38:1195-1204 (1983)). These drugs are not effective, however, in all patients having uninhibited bladder contractions. Administration of anticholinergic medications represent the mainstay of this type of treatment.
None of the existing commercial drug treatments for UI, however, has achieved complete success in all classes of UI patients, nor has treatment occurred without significant adverse side effects. For example, drowsiness, dry mouth, constipation, blurred vision, headaches, tachycardia, and cardiac arrhythmia, which are related to the anticholinergic activity of traditional anti-UI drugs, can occur frequently and adversely affect patient compliance. Yet despite the prevalence of unwanted anticholinergic effects in many patients, anticholinergic drugs are currently prescribed for patients having UI. TJie Merck Manual of Medical Information 631-634 (R. Berkow ed., 1997).
Ulcers are sores occurring where the lining of the digestive tract has been eroded by stomach acids or digestive juices. The sores are typically well-defined round or oval lesions primarily occurring in the stomach and duodenum. About 1 in 10 people develop an ulcer. Ulcers develop as a result of an imbalance between acid-secretory factors, also known as "aggressive factors," such as stomach acid, pepsin, and Helicobacter pylori

ENZ0AZ0LYPIPERAZINE DERIVATIVES HAVING MGLURl- AND MGLUR5-ANTAG0NISTIC ACTIVITY
This application claims the benefit of U.S. Provisional Application No. 60/435,917, filed December 24,2002; U.S. Provisional Application No. 60/459,626, filed April 3,2003; and U.S. Provisional Application No. 60/473,856, filed May 29,2003, all of which are incorporated herein by reference in their entirety.
1. FIELD OF THE INVENTION
The present invention relates to Benzoazolylpiperazine Compounds, compositions comprising a Benzoazolylpiperazine Compound and methods for treating or preventing pain, urinary incontinence (UI), an ulcer, inflammatory-bowel disease (IBD), initable-bowel syndrome (IBS), an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis (ALS), dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia or depression, comprising administering to an animal in need thereof an effective amount of a Benzoazolylpiperazine Compound.
2. BACKGROUND OF THE INVENTION
Pain is the most common symptom for which patients seek medical advice and treatment. Pain can be acute or chronic. While acute pain is usually self-limited, chronic pain persists for 3 months or longer and can lead to significant changes in a patient's personality, lifestyle, functional ability and overall quality of life (K.M. Foley, Pain, in Cecil Textbook of Medicine 100-107 (J.C. Bennett and F. Plum eds., 20th ed. 1996)).
Pain has been traditionally managed by administering non-opioid analgesics, such as acetylsalicylic acid, choline magnesium trisalicylate, acetaminophen, ibuprofen, fenoprofen, diflusinal, and naproxen; or opioid analgesics, including morphine, hydromorphone, methadone, levorphanol, fentanyl, oxycodone, and oxymorphone. Id.
UI is uncontrollable urination, generally caused by bladder-detrusor-muscle instability. UI affects people of all ages and levels of physical health, both in health care settings and in the community at large. At present, UI afflicts 15-30% of elderly people living at home, one-third of those living in acute-care settings, and at least one-half of those

infection, and local mucosal-protective factors, such as secretion of bicarbonate, mucus, and prostaglandins.
Treatment of ulcers typically involves reducing or inhibiting the aggressive factors. For example, antacids such as aluminum hydroxide, magnesium hydroxide, sodium bicarbonate, and calcium bicarbonate can be used to neutralize stomach acids. Antacids, however, can cause alkalosis, leading to nausea, headache, and weakness. Antacids can also interfere with the absorption of other drugs into the blood stream and cause diarrhea.
H2 antagonists, such as cimetidine, ranitidine, famotidine, and nizatidine, are also used to treat ulcers. H2 antagonists promote ulcer healing by reducing gastric acid and digestive-enzyme secretion elicited by histamine and other H2 agonists in the stomach and duodenum. H2 antagonists, however, can cause breast enlargement and impotence in men, mental changes (especially in the elderly), headache, dizziness, nausea, myalgia, diarrhea, rash, and fever.
H+, K+ - ATPase inhibitors such as omeprazole and lansoprazole are also used to treat ulcers. H+, K+ - ATPase inhibitors inhibit the production of enzymes used by the stomach to secrete acid. Side effects associated with H+, K+ - ATPase inhibitors include nausea, diarrhea, abdominal colic, headache, dizziness, somnolence, skin rashes, and transient elevations of plasma activities of aminotransferases.
Sucraflate is also used to treat ulcers. Sucraflate adheres to epithelial cells and is believed to form a protective coating at the base of an ulcer to promote healing. Sucraflate, however, can cause constipation, dry mouth, and interfere with the absorption of other drugs.
Antibiotics are used when Helicobacter pylori is the underlying cause of the ulcer. Often antibiotic therapy is coupled with the administration of bismuth compounds such as bismuth subsalicylate and colloidal bismuth citrate. The bismuth compounds are believed to enhance secretion of mucous and HC03", inhibit pepsin activity, and act as an antibacterial against H pylori. Ingestion of bismuth compounds, however, can lead to elevated plasma concentrations of Bi+3 and can interfere with the absorption of other drugs.
Prostaglandin analogues, such as misoprostal, inhibit secretion of acid and stimulate the secretion of mucous and bicarbonate and are also used to treat ulcers, especially ulcers in patients who require nonsteroidal anti-inflammatory drugs. Effective oral doses of

prostaglandin analogues, however, can cause diarrhea and abdominal cramping. In addition, some prostaglandin analogues are abortifacients.
Carbenoxolone, a mineral corticoid, can also be used to treat ulcers. Carbenoxolone appears to alter the composition and quantity of mucous, thereby enhancing the mucosal barrier. Carbenoxolone, however, can lead to Na+ and fluid retention, hypertension, hypokalemia, and impaired glucose tolerance.
Muscarinic cholinergic antagonists such as pirenzapine and telenzapine can also be used to reduce acid secretion and treat ulcers. Side effects of muscarinic cholinergic antagonists include dry mouth, blurred vision, and constipation. TIte Merck Manual of Medical Information 496-500 (R. Berkow ed., 1997) and Goodman and Oilman *s TJie Pharmacological Basis of Therapeutics 901-915 (J. Hardman and L. Limbird eds., 9th ed. 1996).
IBD is a chronic disorder in which the bowel becomes inflamed, often causing recurring abdominal cramps and diarrhea. The two types of IBD are Crohn's disease and ulcerative colitis.
Crohn's disease, which can include regional enteritis, granulomatous ileitis, and ileocolitis, is a chronic inflammation of the intestinal wall. Crohn's disease occurs equally in both sexes and is more common in Jews of eastern-European ancestry. Most cases of Crohn's disease begin before age 30 and the majority start between the ages of 14 and 24. > The disease typically affects the full thickness of the intestinal wall. Generally the disease affects the lowest portion of the small intestine (ileum) and the large intestine, but can occur in any part of the digestive tract.
Early symptoms of Crohn's disease are chronic diarrhea, crampy abdominal pain, fever, loss of appetite, and weight loss. Complications associated with Crohn's disease include the development of intestinal obstructions, abnormal connecting channels (fistulas), and abscesses. The risk of cancer of the large intestine is increased in people who have Crohn's disease. Often Crohn's disease is associated with other disorders such as gallstones, inadequate absorption of nutrients, amyloidosis, arthritis, episcleritis, aphthous stomatitis, erythema nodosum, pyoderma gangrenosum, ankylosing spondylitis, sacroilitis, uveitis, and primary sclerosing cholangitis. There is no known cure for Crohn's disease.

Cramps and diarrhea, side effects associated with Crohn's disease, can be dlieved by anticholinergic drugs, diphenoxylate, loperamide, deodorized opium tincture, or Ddeine. Generally, the drug is taken orally before a meal.
Broad-spectrum antibiotics are often administered to treat the symptoms of rohn's disease. The antibiotic metronidazole is often administered when the disease affects le large intestine or causes abscesses and fistulas around the anus. Long-term use of letronidazole, however, can damage nerves, resulting in pins-and-needles sensations in the forms and legs. Sulfasalazine and chemically related drugs can suppress mild inflammation, specially in the large intestine. These drugs, however, are less effective in sudden, severe lare-ups. Corticosteroids, such as prednisone, reduce fever and diarrhea and relieve bdominal pain and tenderness. Long-term corticosteroid therapy, however, invariably results n serious side effects such as high blood-sugar levels, increased risk of infection, steoporosis, water retention, and fragility of the skin. Drugs such as azathioprine and nercaptourine can compromise the immune system and are often effective for Crohn's lisease in patients that do not respond to other drugs. These drugs, however, usually need 3 o 6 months before they produce benefits and can cause serious side effects such as allergy, pancreatitis, and low white-blood-cell count.
When Crohn's disease causes the intestine to be obstructed or when abscesses 3r fistulas do not heal, surgery can be necessary to remove diseased sections of the intestine. Surgery, however, does not cure the disease, and inflammation tends to recur where the intestine is rejoined. In almost half of the cases a second operation is needed. The Merck Manual of Medical Information 528-530 (R. Berkow ed., 1997).
Ulcerative colitis is a chronic disease in which the large intestine becomes inflamed and ulcerated, leading to episodes of bloody diarrhea, abdominal cramps, and fever. Ulcerative colitis usually begins between ages 15 and 30; however, a small group of people have their first attack between ages 50 and 70. Unlike Crohn's disease, ulcerative colitis never affects the small intestine and does not affect the full thickness of the intestine. The disease usually begins in the rectum and the sigmoid colon and eventually spreads partially or completely through out the large intestine. The cause of ulcerative colitis is unknown.
Treatment of ulcerative colitis is directed to controlling inflammation, reducing symptoms, and replacing lost fluids and nutrients. Anticholinergic drugs and low

doses of diphenoxylate or loperamide are administered for treating mild diarrhea. For more intense diarrhea higher doses of diphenoxylate or loperamide, or deodorized opium tincture or codeine are administered. Sulfasalazine, olsalazie, prednisone, or mesalamine can be used to reduce inflammation. Azathioprine and mercaptopurine have been used to maintain remissions in ulcerative-colitis patients who would otherwise need long-term corticosteroid treatment. In severe cases of ulcerative colitis the patient is hospitalized and given corticosteroids intravenously. People with severe rectal bleeding can require transfusions and intravenous fluids. If toxic colitis develops and treatments fail, surgery to remove the large intestine can be necessary. Non-emergency surgery can be performed if cancer is diagnosed, precancerous legions are detected, or unremitting chronic disease would otherwise make the person an invalid or dependent on high doses of corticosteroids. Complete removal of the large intestine and rectum permanently cures ulcerative colitis. The Merck Manual of Medical Information 530-532 (R. Berkow ed., 1997) and Goodman and Gilman 's The Pharmacological Basis of Titerapeutics (J. Hardman and L. Limbird eds., 9th ed. 1996).
IBS is a disorder of motility of the entire gastrointestinal tract, causing abdominal pain, constipation, and/or diarrhea. IBS affects three-times more women than men. In IBS stimuli such as stress, diet, drugs, hormones, or irritants can cause the gastrointestinal tract to contract abnormally. During an episode of IBS contractions of the gastrointestinal tract become stronger and more frequent, resulting in the rapid transit of food and feces through the small intestine, often leading to diarrhea. Cramps result from the strong contractions of the large intestine and increased sensitivity of pain receptors in the large intestine.
There are two major types of IBS. The first type, spastic-colon type, is commonly triggered by eating, and usually produces periodic constipation and diarrhea with pain. Mucous often appears in the stool. The pain can come in bouts of continuous dull aching pain or cramps, usually in the lower abdomen. The person suffering from spastic-colon type IBS can also experience bloating, gas, nausea, headache, fatigue, depression, anxiety, and difficulty concentrating. The second type of IBS usually produces painless diarrhea or constipation. The diarrhea can begin suddenly and with extreme urgency. Often the diarrhea occurs soon after a meal and can sometimes occur immediately upon awakening.

Treatment of IBS typically involves modification of an IBS-patient's diet. Often it is recommended that an IBS patient avoid beans, cabbage, sorbitol, and fructose. A low-fat, high-fiber diet can also help some IBS patients. Regular physical activity can also help keep the gastrointestinal tract functioning properly. Drugs such as propantheline that slow the function of the gastrointestinal tract are generally not effective for treating IBS. Antidiarrheal drugs, such as diphenoxylate and loperamide, help with diarrhea. Hie Merck Manual of Medical Information 525-526 (R. Berkow ed., 1997).
Many drugs can cause physical and/or psychological addiction. Those most well known types of these drugs include opiates, such as heroin, opium, and morphine; sympathomimetics, including cocaine and amphetamines; sedative-hypnotics, including alcohol, benzodiazepines and barbiturates; and nicotine, which has effects similar to opioids and sympathomimetics. Drug addiction is characterized by a craving or compulsion for taking the drug and an inability to limit its intake. Additionally, drug dependence is associated with drug tolerance, the loss of effect of the drug following repeated administration, and withdrawal, the appearance of physical and behavioral symptoms when the drug is not consumed. Sensitization occurs if repeated administration of a drug leads to an increased response to each dose. Tolerance, sensitization, and withdrawal are phenomena evidencing a change in the central nervous system resulting from continued use of the drug. This change can motivate the addicted individual to continue consuming the drug despite serious social, legal, physical and/or professional consequences. (See, e.g., U.S. Patent No. 6,109,269 to Rise etal).
Certain pharmaceutical agents have been administered for treating addiction. U.S. Patent No. 5,556,838 to Mayer et ah discloses the use of nontoxic NMDA-blocking agents co-administered with an addictive substance to prevent the development of tolerance or withdrawal symptoms. U.S. Patent No. 5,574,052 to Rose et ah discloses coadministration of an addictive substance with an antagonist to partially block the pharmacological effects of the substance. U.S. Patent No. 5,075,341 to Mendelson et ah discloses the use of a mixed opiate agonist/antagonist to treat cocaine and opiate addiction. U.S. Patent No. 5,232,934 to Downs discloses administration of 3-phenoxypyridine to treat addiction. U.S. Patents No. 5,039,680 and 5,198,459 to hnperato et ah disclose using a serotonin antagonist to treat chemical addiction. U.S. Patent No. 5,556,837 to Nestler et. al.

liscloses infusing BDNF or NT-4 growth factors to inhibit or reverse neurological adaptive changes that correlate with behavioral changes in an addicted individual. U.S. Patent. No. 5,762,925 to Sagan discloses implanting encapsulated adrenal medullary cells into an animal's central nervous system to inhibit the development of opioid intolerance. U.S. Patent No. 6,204,284 to Beer et al discloses racemic (±)-l-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane for use in the prevention or relief of a withdrawal syndrome resulting from addiction to drugs and for the treatment of chemical dependencies.
Parkinson's disease is a clinical syndrome comprising bradykinesia (slowness and poverty of movement), muscular rigidity, resting tremor (which usually abates during voluntary movement), and an impairment of postural balance leading to disturbance of gait and falling. The features of Parkinson's disease are a loss of pigmented, dopaminergic neurons of the substantia nigra pars compacta and the appearance of intracellular inclusions known as Lewy bodies (Goodman and Gillman 's The Pharmaceutical Basis ofTIterapeutics 506 (9th ed. 1996)). Without treatment, Parkinson's disease progresses to a rigid akinetic state in which patients are incapable of caring for themselves. Death frequently results from complications of immobility, including aspiration pneumonia or pulmonary embolism. Drugs commonly used for the treatment of Parkinson's disease include carbidopa/levodopa, pergolide, bromocriptine, selegiline, amantadine, and trihexyphenidyl hydrochloride. There remains, however, a need for drugs useful for the treatment of Parkinson's disease and having an improved therapeutic profile.
Anxiety is a fear, apprehension, or dread of impending danger often accompanied by restlessness, tension, tachycardia, and dyspnea. Other symptoms commonly associated with anxiety include depression, especially accompanied with dysthymic disorder (chronic "neurotic" depression); panic disorder; agoraphobia and other specific phobias; eating disorders; and many personality disorders. Often anxiety is unattached to a clearly identified treatable primary illness. If a primary illness is found, however, it can be desirable to deal with the anxiety at the same time as the primary illness.
Currently, benzodiazepines are the most commonly used anti-anxiety agents for generalized anxiety disorder. Benzodiazepines, however, carry the risk of producing impairment of cognition and skilled motor functions, particularly in the elderly, which can result in confusion, delerium, and falls with fractures. Sedatives are also commonly

prescribed for treating anxiety. The azapirones, such as buspirone, are also used to treat moderate anxiety. The azapirones, however, are less useful for treating severe anxiety accompanied with panic attacks.
Epilepsy is a disorder characterized by the tendency to have recurring seizures. The etiology commonly consists of lesions in some part of the cortex, such as a tumor; developmental malformation; or damage due to trauma or stroke. In some cases the etiology is genetic. An epileptic seizure can be triggered by repetitive sounds, flashing lights, video games, or touching certain parts of the body. Epilepsy is typically treated with anti-seizure drugs. In epilepsy cases, where anti-seizure drugs are ineffective, and the defect in the brain is isolated to a small area of the brain, surgical removal of that part of the brain can be helpful in alleviating the seizures. In patients who have several sources for the seizures or who have seizures that spread quickly to all parts of the brain, surgical removal of the nerve fibers that connect the two sides of the brain can be helpful.
Examples of drugs for treating a seizure and epilepsy include carbamazepine, ethosuximide, gabapentin, lamotrignine, phenobarbital, phenytoin, primidone, valproic acid, trimethadione, bemzodiaepines, y-vinyl GABA, acetazolamide, and felbamate. Anti-seizure drugs, however, can have side effects such as drowsiness; hyperactivity; hallucinations; inability to concentrate; central and peripheral nervous system toxicity, such as nystagmus, ataxia, diplopia, and vertigo; gingival hyperplasia; gastrointestinal disturbances such as nausea, vomiting, epigastric pain, and anorexia; endocrine effects such as inhibition of antidiuretic hormone, hyperglycemia, glycosuria, osteomalacia; and hypersensitivity such as scarlatiniform rash, morbilliform rash, Stevens-Johnson syndrome, systemic lupus erythematosus, and hepatic necrosis; and hematological reactions such as red-cell aplasia, agranulocytosis, thrombocytopenia, aplastic anemia, and megaloblastic anemia. The Merck Manual of Medical Information 345-350 (R. Berkow ed., 1997).
A seizure is the result of abnormal electrical discharge in the brain. The discharge can involve a small area of the brain and lead to the person only noticing an odd taste or smell or it can involve a large area of the brain and lead to convulsions, i.e., a seizure that causes jerking and spasms of the muscles throughout the body. Convulsions can also result in brief attacks of altered consciousness and loss of consciousness, muscle control, or bladder control. A seizures is often preceded by auras, i.e., unusual sensations of smell, taste,

vision or an intense feeling that a seizure is about to begin. A seizure typically lasts for out 2 to 5 minutes. When the seizure ends the person can have headache, sore muscles, usual sensations, confusion, and profound fatigue (postictal state). Usually the person nnot remember what happened during the seizure.
A stroke or cerebrovascular accident, is the death of brain tissue (cerebral farction) resulting from the lack of blood flow and insufficient oxygen to the brain. A roke can be either ischemic or hemorrhagic. In an ischemic stroke, blood supply to the rain is cut off because of athersclerosis or a blood clot that has blocked a blood vessel. In a smorrhagic stroke, a blood vessel bursts preventing normal blood flow and allowing blood leak into an area of the brain and destroying it. Most strokes develop rapidly and cause rain damage within minutes. In some cases, however, strokes can continue to worsen for everal hours or days. Symptoms of strokes vary depending on what part of the brain is ffected. Symptoms include loss or abnormal sensations in an arm or leg or one side of the body, weakness or paralysis of an arm or leg or one side of the body, partial loss of vison or tearing, double vision, dizziness, slurred speech, difficulty in thinking of the appropriate vord or saying it, inability to recognize parts of the body, unusual movements, loss of bladder control, imbalance, and falling, and fainting. The symptoms can be permanent and can be associated with coma or stupor. Strokes can cause edema or swelling of the brain which can further damage brain tissue. For persons suffering from a stroke, intensive rehabilitation can help overcome the disability caused by impairment of brain tissue. Rehabilitation trains other parts of the brain to assume the tasks previously performed by the damaged part.
Examples of drugs for treating strokes include anticoagulants such as heparin, drugs that break up clots such as streptokinase or tissue plasminogen activator, and drugs that reduce swelling such as mannitol or corticosteroids. The Merck Manual of Medical Information 352-355 (R. Berkow ed., 1997).
Pruritus is an unpleasant sensation that prompts scratching. Pruritus can be attributed to dry skin, scabies, dermatitis, herpetiformis, atopic dermatitis, pruritus vulvae et ani9 miliaria, insect bites, pediculosis, contact dermatitis, drug reactions, urticaria, urticarial eruptions of pregnancy, psoriasis, lichen planus, lichen simplex chronicus, exfoliative dermatitis, folliculitis, bullous pemphigoid, and fiberglass dermatitis. Conventionally,

pruritus is treated by phototherapy with ultraviolet B or PUVA or with therapeutic agents such as naltrexone, nalmefene, danazol, tricyclics, and antidepressants.
Selective antagonists of the metabotropic glutamate receptor 5 ("mGluR5") have been shown to exert analgesic activity in in vivo animal models (K. Walker et ah9 Neuropharmacology 40:1-9 (2000) and A. Dogrul et ah9 Neuroscience Letters, 292(2): 115-118(2000)).
Selective antagonists of the mGluR5 receptor have also been shown to exert anxiolytic and anti-depressant activity in in vivo animal models (E. Tatarczynska et ah9 Br. J. Pharmacol 132(7): 1423-1430 (2001) and P.J.M. Will et ah9 Trends in Pharmacological Sciences 22(7):331-37 (2001)).
Selective antagonists of the mGluR5 receptor have also been shown to exert anti-Parkinson activity in vivo (K. J. Ossowska et aL9 Neuropharmacology 41(4) :413-20 (2001) and P.J.M. Will et al9 Trends in Pharmacological Sciences 22(7):331-37 (2001)).
Selective antagonists of the mGluR5 receptor have also been shown to exert anti-dependence activity in vivo (C Chiamulera et al9 Nature Neuroscience 4(9): 873-74 (2001)).
U.S. Patent No. 6,150,129 to Cook et ah describes a class of dinitrogen heterocycles useful as antibiotics.
U.S. Patent No. 5,529,998 to Habich et ah describes a class of benzooxazolyl-and benzothiazolyloxazolidones useful as antibacterials.
International publication no. WO 01/57008 describes a class of 2-benzothiazolyl urea derivatives useful as inhibitors of serine/threonine and tyrosine kinases.
International publication no. WO 02/08221 describes aryl piperazine compounds useful for treating chronic and acute pain conditions, itch, and urinary incontinence.
International publication no. WO 99/37304 describes substituted oxoazaheterocycly compounds useful for inhibiting factor Xa.
International publication no. WO 00/59510 describes aminopyrimidines useful as sorbitol dehydrogenase inhibitors.

Japanese patent application no. 11-199573 to Kiyoshi et al describes benzothiazole derivatives that are neuronal 5HT3 receptor agonists in the intestinal canal nervous system and useful for treating digestive disorders and pancreatic insufficiency.
German patent application no 199 34 799 to Rainer et al describes a chiral-smectic liquid crystal mixture containing compounds with 2 linked (hetero)aromatic rings or compounds with 3 linked (hetero)aromatic rings.
M. Chu-Moyer et al, 1 Med. Chem. 45:511-528 (2002) describes heterocycle-substituted piperazino-pyrimidines useful as sorbitol dehydrogenase inhibitors.
B.G. Khadse et al, Bull Haffi Instt. l(3):27-32 (1975) describes 2-(N4-substituted-N^piperazinyl) pyrido(3,2-d)thiazoles and 5-nitro-2-(N4-substituted-N1-piperazinyl)benzthiazoles useful as anthelmintic agents.
There remains, however, a clear need in the art for new drugs useful for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, ALS, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression.
Citation of any reference in Section 2 of this application is not to be construed as an admission that such reference is prior art to the present application.




CH)bicycloalkenyl, -(C8-C14)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R5 groups; or
(c) -phenyl, -naphthyl, -(CM)aryl or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R6 groups;
R4 is -H or -(C,-C6)alkyl;
each R5 is independently -CN, -OH, -halo, ~N3, -N02, -N(R7)2, -CH=NR7, -NR7OH, -0R7, -COR7, -C(0)OR7, -OC(0)R7, -OC(0)OR7, -SR7, -S(0)R7, or -S(0)2R7;
each R6 is independently -(C,-C6)alkyl, -(C2-C6)alkenyl, -(C2-C6)alkynyl, -(C3-C8)cycloalkyl, -(C5-C8)cycloalkenyl, -phenyl, -(C3-C5)heterocycle, -C(halo)3, -CH(halo)2, -CH2(halo), -CN, -OH, -halo, -N3, -N02, -N(R7)2, -CH=NR7, -NR7OH, -OR7, -COR7, -C(0)OR7, -OC(0)R7, -OC(0)OR7, -SR7, -S(0)R7, or -S(0)2R7;
each R7 is independently -H, -(C1-C6)alkyl, -(C2-C6)alkenyl, -(C2-C6)alkynyl, -(C3-C8)cycloalkyl, -(C5-C8)cycloalkenyl, -phenyl, -(C3-C5)heterocycle, -C(halo)3, -CH2(halo), or -CH(halo)2;
R8 and R9 are each independently -H, -(C1-C6)alkyl, -(C2-C6)alkenyl, -(C2-C6)alkynyl, -(C3-C8)cycloalkyl, -(C5-C8)cycloalkenyl, -phenyl, -C(halo)3, -CH(halo)2, -CH2(halo), -OC(halo)3 -OCH(halo)2, -OCH2(halo), -CN, -OH, -halo, -N3, -N(R7)2, -CH=NR7, -NR7OH, -OR7, -COR7, -C(0)OR7, -OC(0)R7, -OC(0)OR7, -SR7, -S(0)R7, or -S(0)2R7;
each -halo is -F, -CI, -Br,- or -I;
n is an integer ranging from 0 to 3;
p is an integer ranging from 0 to 2;
misOor l;and
xis Oor 1.
The present invention encompasses compounds having the formula (lb):



(c) -phenyl, -naphthyl, -(C14)aryl, or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R6 groups;
each R3 is independently:
(a) -halo, -CN, -OH, -0(C1-C6)alkyl, -N02, or -NH2;
(b) -C1-C10alkyl, -(C2-C10)alkenyl, -(C2-C10)alkynyl, -(C3-C10)cycloalkyl, -(C8-C14)bicycloalkyl, -(C8-C14)tricycloalkyl, -(C5-C10)cycloalkenyl,-(C8-C14)bicycloalkenyl, -(C8-C14)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R5 groups; or
(c) -phenyl, -naphthyl, -(C14)aryl or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R6 groups;
R4 is -H or -(C1-C6)alkyl;
each Rj is independently -CN, -OH, -halo, -N3, -N02, -N(R7)2, -CH=NR7, -NR7OH, -OR7, -COR7, -C(0)OR7, -OC(0)R7, -OC(0)OR7, -SR7, -S(0)R7, or -S(0)2R7;
each Rg is independently -alkyl, -(C2-C6)alkenyl, -(C2-C6)alkynyl, -(C3-C8)cycloalkyl, -(C5-C8)cycloalkenyl, -phenyl, -(C3-C5)heterocycle, -C(halo)3, -CH(halo)2, -CH2(halo), -CN, -OH, -halo, -N3, -N02, -N(R7)2, -CH=NR7, -NR7OH, -OR7, \ -COR7, -C(0)OR7, -OC(0)R7, -OC(0)OR7, -SR7, -S(0)R7, or -S(0)2R7;
each R7 is independently -H, alkyl, -(C2-C6)alkenyl, -(Q-C^alkynyl, -(C3-C8)cycloalkyl, -(C5-C8)cycloalkenyl, -phenyl, -(C3-C5)heterocycle, -C(halo)3, -CH2(halo), or-CH(halo)2;
R8 and R> are each independently -H, -(C1-C6)alkyl, -(C2-C6)alkenyl, -(C2-C6)alkynyl, -(C3-C8)cycloalkyl, -(C5-C8)cycloalkenyl, -phenyl, -C(halo)3, -CH(halo)2, -CH2(halo), -OC(halo)3, -OCH(halo)2, -OCH2(halo), -CN, -OH, -halo, -N3, -N(R7)2, -CH=NR7, -NR7OH, -OR7, -COR7, -C(0)OR7, -OC(0)R7, -OC(0)OR7, -SR7, -S(0)R7, or -S(0)2R7;
each -halo is -F, -CI, -Br,- or -I;
p is an integer ranging from 0 to 2;
mis or l;and

xisOor 1.
The present invention encompasses compounds having the formula (Ha):

R, is -CI, -Br, -I, -(C1-C6)alkyl, -N02, -CN, -OH, -OCH3, -NH2, -C(halo)3, -CH(halo)2, or -CH2(halo);
each R2 is independently:
(a) -halo, -CN, -OH, -0(CrC6)alkyl, -N02, or -NH2;
(b) -(CrC10)alkyl, -(C2-C10)alkenyl, -(C2-C10)alkynyl, -(C3-
C10)cycloalkyl, -(C8-C14)bicycloalkyl, -(C8-C14)tricycloalkyl, -(C5-C10)cycloalkenyl,-(C8-
C14)bicycloalkenyl, -(C8-C14)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-
membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more
Rs groups; or



























The invention also relates to compositions comprising an effective amount of a Benzoazolylpiperazine Compound and a pharmaceutically acceptable carrier or excipient. The compositions are useful for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, ALS, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal.
The invention further relates to methods for treating pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, ALS, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression comprising administering to an animal in need thereof an effective amount of a Benzoazolylpiperazine Compound.
The invention further relates to methods for preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, ALS, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression comprising administering to an animal in need thereof an effective amount of a Benzoazolylpiperazine Compound.
The invention still further relates to methods for inhibiting Vanilloid Receptor 1 ("VR1") function in a cell, comprising contacting a cell capable of expressing VR1 with an effective amount of a Benzoazolylpiperazine Compound.
The invention still further relates to methods for inhibiting mGluR5 function in a cell, comprising contacting a cell capable of expressing mGluR5 with an effective amount of a Benzoazolylpiperazine Compound.
The invention still further relates to methods for inhibiting metabotropic glutamate receptor 1 ("mGluRl") function in a cell, comprising contacting a cell capable of expressing mGluRl with an effective amount of a Benzoazolylpiperazine Compound.
The invention still further relates to a method for preparing a composition comprising the step of admixing a Benzoazolylpiperazine Compound and a pharmaceutically acceptable carrier or excipient.












and pharmaceutical^ acceptable salts thereof, where Ar„ R3, Rg, R^, A, x, and m, are defined above for the Benzoazolylpiperazine Compounds of formula (la).
In one embodiment, Ax} is a pyridyl group.
In another embodiment, Art is a pyrimidinyl group.
In another embodiment, x is 1 and A is -C(0)-N(R4)-.
In another embodiment, x is 1 and A is -C(S)-N(R4)-.
In another embodiment x is 0.
In another embodiment, n or p is 0.
In another embodiment, n or p is 1.
In another embodiment, m is 0.
In another embodiment, m is 1.
In another embodiment, R4 is -H.
In another embodiment, R4 is -(C^C^alkyl.
In another embodiment, Ar, is a pyridyl group, x is 1, and A is -C(0)N(R4)-.
In another embodiment, Ar! is a pyridyl group, x is 1, and A is -C(S)N(R4)-.
In another embodiment, AR1 is a pyrimidinyl group, x is 1, and A is -C(0)N(R4)-.

In another embodiment, Ar, is a pyrimidinyl group, x is 1, and A is -C(S)N(R4)-.
In another embodiment, R1 is -CI.
In another embodiment, R1 is -Br.
In another embodiment, R1 is -I.
In another embodiment, R1 is -(C1-C6)alkyl.
In another embodiment, R1 is -CH3.
In another embodiment, R1 is -N02.
In another embodiment, R, is -CN.
In another embodiment, R1 is -OH.
In another embodiment, R1 is -OCH3.
In another embodiment, Ra is -NH2.
In another embodiment, R1 is -C(halo)3.
In another embodiment, R1 is -CH(halo)2.
In another embodiment, R1 is -CH2(halo).
In another embodiment, n and p are 1 and R2 is -halo, -CN, -OH, -0(C,-C6)alkyl, -N02, or -NH2.
In another embodiment, n and p are 1 and R2 is -(C1-C10)alkyl, -(C2-C10)alkenyl, -(C2-C10)alkynyl, -(C3-C10)cycloalkyl, -(C8-C14)bicycloalkyl, -(C8-C14)tricycloalkyl, -(C5-C10)cycloalkenyl,-(C8-C14)bicycloalkenyl, -(C8-C14)tricycloalkenyl, -(3-to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R$ groups.
In another embodiment, n and p are 1 and R2 is -phenyl, -naphthyl, -(C14)aryl, or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R6 groups;
In another embodiment, m is 1 and R3 is -halo, -CN, -OH, -0(C,-C6)alkyl, -N02, or -NH2.
In another embodiment, m is 1 and R3 is -C1-C10alkyl, -(C2-C10)alkenyl, -(C2-C10)alkynyl, -(C3-C10)cycloalkyl, -(C8-C14)bicycloalkyl, -(C8-C14)tricycloalkyl, -(C5-Cl0)cycloalkenyl,-(C8-C14)bicycloalkenyl, -(C8-C14)tricycloaIkenyl, -(3- to 7-

membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R1 groups.
In another embodiment, m is 1 and R3 is -phenyl, -naphthyl, -(C14)aryl or -(5-to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R^ groups.
In another embodiment, R8 and R9 are each independently -H, -halo, -(Cr C6)alkyl, -0(C1-C6)alkyl, -C(halo)3, -CH(halo)2, or -CH2(halo).
In another embodiment, at least one of R8 and Ro is -H.
In another embodiment, n, p, and m are 0; Rx is -CI -Br, or, -I; x is 1; A is -C(0)-N(R4; R4 is -H; and R8 and R9 are -H.
In another embodiment, n, p, and m are 0; R1 is -Cl, x is 1, A is -C(0)-N(R4)-, R4 is -H, and R8 and R9 are -H.
In another embodiment, n, p, and m are 0; Rx is -CI -Br, or -I; x is 1; A is -C(0)-N(R4)-; R4 is -H; R8 is -H; and R9 is -halo. In another embodiment, Rx is -Cl. In another embodiment, R9 is -Cl. In another embodiment, R9 is -Br. In another embodiment, Ro is -F.
In another embodiment, n, p, and m are 0; Rx is -Cl( x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -H, and R9 is -halo. In another embodiment, Rx is -Cl. In another embodiment, Ro is -Cl. In another embodiment, R9 is -Br. In another embodiment, Ro is -F.
In another embodiment, n, p, and m are 0; R9 is -Cl, -Br, or -I; x is 1; A is -C(0)-N(R4)-; R4 is -H; R8 is -halo; and R9 is -H. In another embodiment, Rx is -Cl. In another embodiment, R8 is -Cl. In another embodiment, R8 is -Br. In another embodiment, Rs is -F.
In another embodiment, n, p, and m are 0; Rx is -Cl, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -halo, and R9 is -H. In another embodiment, R, is -Cl. In another embodiment, R8 is -Cl. In another embodiment, R8 is -Br. In another embodiment, R8 is -F.
In another embodiment, n, p, and m are 0; Rx is -Cl -Br, or -I; x is 1; A is -C(0)-N(R4)-; R4 is - is -H; and R9 is -CH3.
In another embodiment, n, p, and m are 0; is -Cl x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -H, and R9 is -CH3.
In another embodiment, n, p, and m are 0; R, is -Cl -Br, or -I; x is 1; A is

:(0)-N(R4)-; R4 is -H; R8 is -CH3; and R9 is -H.
In another embodiment, n, p, and m are 0; R1 is -G x is 1, A is -C(0)-N(R4)-, .4 is -H, R8 is -CH3, and R is -H.
In another embodiment, n, p, and m are 0; R is -Cl -Br, or -I; x is 1; A is C(0)-N(R4>; R4 is -H; R8 is -H; and R9 is -CF3.
In another embodiment, n, p, and m are 0; R5 is -CI. x is 1; A is -C(0)-N(R4)-; L4 is -H; Rg is -H; and R9 is -CF3.
In another embodiment, n, p, and m are 0; R, is -Cl -Br, or -I; x is 1; A is C(0>N(R4); R4 is -H; R8 is -CF3; and R9 is -H.
In another embodiment, n, p, and m are 0; R, is -CI. x is 1; A is -C(0)-N(R4)-; l4 is -H; R8 is -CF3; and R9 is -H.
In another embodiment, n, p, and m are 0; is -Cl^ -Br, or -I; x is 1; A is C(0)-N(R4)s R4 is -H; R8 is -H; and R9. is -OCH2CH3.
In another embodiment, n, p, and m are 0; Rj is -CI. x is 1; A is -C(0)-N(R4)-; R4 is -H; R8 is -H; and R9 is -OCH2CH3.
Li another embodiment, n, p, and m are 0; Rj is -CI -Br, or -I; x is 1; A is ■C(0)-N(R4)-; R4 is -H; R8 is -OCH2CH3; and R* is -H.
In another embodiment, n, p, and m are 0; Rj is -CI. x is 1; A is -C(0)-N(R4)-; R4 is -H; R8 is -OCH2CH3; and R9 is -H.
In another embodiment, n, p, and m are 0; Rj is -CH3. x is 1; A is -C(0)-N(R4)-; R4 is -H; and R8 and Ro are -H.
In another embodiment, n, p, and m are 0; R5 is -CH3; x is 1; A is -C(0)-N(R4)-; R4 is -H; R8 is -H; and R9 is -halo. In another embodiment, R$ is -Cl. In another embodiment, R9 is -Br. In another embodiment, R9 is -F.
In another embodiment, n, p, and m are 0; Rt is -CH3; x is 1; A is -C(0)-N(R4)-; R4 is -H; R8 is -halo; and R9 is -H. In another embodiment, R8 is -Cl. In another embodiment, R8 is -Br. In another embodiment, R8 is -F.
In another embodiment, n, p, and m are 0; R1 is -CH3; x is 1; A is -C(0)-N(R4)-; R4 is -H; R8 is -H; and R9 is -CH3.
In another embodiment, n, p, and m are 0; Rt is -CH3. x is 1; A is -C(0)-N(R4)-; R4 is -H; R8 is -CH3; and R9 is -H.

In another embodiment, n, p, and xn are 0; - is -CH3; x is 1; A is C(0)-N(R4)-; R4 is -H; R8 is -H; and R, is -CF3.
In another embodiment, n, p, and m are 0; Rx is -CH3. x is 1; A is C(0)-N(R4)-; R4 is -H; R8 is -CF3; and R, is -H.
In another embodiment, n, p, and m are 0; Rx is -CH3. x is 1; A is C(0)-N(R4)s R4 is -H; R8 is -H; and R, is -OCH2CH3.
In another embodiment, n, p, and m are 0; - is -CH3. x is 1; A is C(0)-N(R4>; R4 is -H; R8 is -OCH2CH3; and R9 is -H.
In another embodiment, n, p, and m are 0; R, is -CF3. x is 1; A is C(0)-N(R4)-; R4 is -H; and R8 and R9 are -H.
In another embodiment, n, p, and m are 0; - is -CF3; x is 1; A is C(0)-N(R4)-; R4 is -H; R8 is -H; and R9 is -halo. In another embodiment, R9 is -CL In mother embodiment, R9 is -Br. In another embodiment, R9 is -F.
In another embodiment, n, p, and m are 0; R, is -CF3. x is 1; A is •C(0)-N(R4)-; R4 is -H; R8 is -halo; and R9 is -H. In another embodiment, R8 is -CI. In mother embodiment, R8 is -Br. In another embodiment, R8 is -F.
In another embodiment, n, p, and m are 0; R} is -CF3; x is 1; A is -C(0)-N(R4)-; R4 is -H; R8 is -H; and R9 is -CH3.
In another embodiment, n, p, and m are 0; R! is -CF3. x is 1; A is -C(0)-N(R4)-; R4 is -H; R8 is -CH3; and is -H.
In another embodiment, n, p, and m are 0; - is -CF3; x is 1; A is -C(0)-N(R4)-; R4 is -H; R8 is -H; and R9 is -CF3.
In another embodiment, n, p, and m are 0; Rx is -CF3; x is 1; A is -C(0)-N(R4)-; R4 is -H; R8 is -CF3; and Rg is -H.
In another embodiment, n, p, and m are 0; R3 is -CF3; x is 1; A is -C(0)-N(R4)-; R4 is -H; R8 is -H; and R, is -OCH2CH3.
In another embodiment, n, p, and m are 0; Rx is -CF3; x is 1; A is -C(0)-N(R4)-; R4 is -H; R8 is -OCH2CH3; and R, is -H.
In another embodiment, n, p, and m are 0; R} is -CI -Br, or -I; x is 1; A is -C(0)-N(R4)s R4 is -H; R8 is -ter/-butyl; and R9 is -H.

In another embodiment, n, p, and m are 0; Rx is -CI. x is 1; A is -C(0)-N(R4)s R4 is -H; R8 is -tert-butyl; and R9 is -H.
In another embodiment, n, p, and m are 0; R} is Rx is -CI, -Br, or -I; x is 1; A is -C(0)-N(R4)-; R4 is -H; R8 is -H; and R* is -tert-butyl.
In another embodiment, n, p, and m are 0; Rx is Rx is -CI. x is 1; A is -C(O)-N(R4)-; R4 is -H; R8 is -H; and R9 is -tert-butyl.
In another embodiment, n, p, and m are 0; Rx is -CH3; x is 1; A is -C(0)-N(R4>; R4 is -H; R8 is -ferf-butyl; and R9 is -H.
In another embodiment, n, p, and m are 0; R, is -CH3; x is 1; A is -C(O)-N(R4)-; R4 is -H; R8 is -H; and R9 is -tert-hatyl.
In another embodiment, n, p, and m are 0; R! is -CH3; x is 1; A is -C(O)-N(R4>; R4 is -H; Rg is -CH3; and R9 is -CH3.
In another embodiment, n is 0, Axx is -2-(3-nitR9pyridyl)-, m is 0, x is 0, and R8 and R$ are -H.
In another embodiment, n is 0, Ar1 is -2-(3-chloR9pyridyl)-, x is 1, A is -C(S)-N(R4)-, m is 1, R3 is -CH3, R3 is attached to the carbon atom adjacent to the nitR9gen attached to the -C(SO)-N(R4)- gR9up, the carbon atom to which the R3 gR9up is attached has the R configuration, R8 is -H, and R9 is -CH3.
In another embodiment, n and p are 0; m is 1; Rx is -CI, -Br, or -I. x is 1; A is -C(0)-N(R4)-; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- gR9up; and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 gR9up is attached has the R configuration. In another embodiment, the carbon atom to which the R3 gR9up is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, Rx is -CI x is 1, A is -C(O)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- gR9up, and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 gR9up is attached has the R configuration. In another embodiment, the carbon atom to which the R3 gR9up is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; R, is -CI, -Br, or -I; x is 1; A is -C(0)-N(R4)-; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- gR9up; R8 is -H; and R9 is -halo. In another embodiment R9 is

-CI. In another embodiment, R9 is -Br. In another embodiment, R9 is -F. In another embodiment, the carbon atom to which the R3 gR9up is attached has the R configuration. In another embodiment, the carbon atom to which the R3 gR9up is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, Rx is -CI x is 1, A is -C(O)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- gR9up, R8 is -H, and R9 is -halo. In another embodiment R is -CI. In another embodiment, R9 is -Br. In another embodiment, R9 is -F. In another embodiment, the carbon atom to which the R3 gR9up is attached has the R configuration. In another embodiment, the carbon atom to which the R3 gR9up is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; R, is -CI, -Br, or -I; x is 1; A is -C(0)-N(R4)-; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- gR9up; R8 is -halo; and R9 is -H. In another embodiment R8 is -CI. In another embodiment, R8 is -Br. In another embodiment, R8 is -F. In another embodiment, the carbon atom to which the R3 gR9up is attached has the R configuration. In another embodiment, the carbon atom to which the R3 gR9up is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, R, is -CI, x is 1, A is -C(O)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- gR9up, R8 is -halo, and R9 is -H. In another embodiment R8 is -CL In another embodiment, R8 is -Br. In another embodiment, Rg is -F. In another embodiment, the carbon atom to which the R3 gR9up is attached has the R configuration. In another embodiment, the carbon atom to which the R3 gR9up is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; K{ is -CI, -Br, or -I; x is 1; A is -C(0)-N(R4)-; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- gR9up; R8 is -H; and R9 is -CH3. In another embodiment, the carbon atom to which the R3 gR9up is attached has the R configuration. In another embodiment, the carbon atom to which the R3 gR9up is attached has the S configuration.

In another embodiment, n and p are 0, m is 1, - is -Cl( x is 1, A is ~C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- gR9up, RS is -H, and R9 is -CH3. In another embodiment, the carbon atom to which the R3 gR9up is attached has the R configuration. In another embodiment, the carbon atom to which the R3 gR9up is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; R} is -CI, -Br, or -I; x is 1; A is -C(0)-N(R4)-; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- gR9up; R8 is -CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 gR9up is attached has the R configuration. In another embodiment, the carbon atom to which the R3 gR9up is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, Ri is -CI x is 1, A is -C(O)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- gR9up, R8 is -CH3, and R9 is -H. In another embodiment, the carbon atom to which the R3 gR9up is attached has the R configuration. In another embodiment, the carbon atom to which the R3 gR9up is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; R} is -CI, -Br, or -I; x is 1; A is -C(0)-N(R4)-; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- gR9up; R8 is -H; and R9 is -CF3. In another embodiment, the carbon atom to which the R3 gR9up is attached has the R configuration. In another embodiment, the carbon atom to which the R3 gR9up is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, R, is -CI x is 1, A is -C(O)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- gR9up, R8 is -H, and R9 is -CF3. In another embodiment, the carbon atom to which the R3 gR9up is attached has the R configuration. In another embodiment, the carbon atom to which the R3 gR9up is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; R, is -CI, -Br, or -I; x is 1; A is -C(0)-N(R4)-; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- gR9up; R8 is -CF3; and R9 is -H. In another embodiment, the carbon atom to which the R3 gR9up is attached has the R configuration. In another embodiment, the carbon atom to which the R3 gR9up is attached has the S configuration.

In another embodiment, n and p are 0, m is 1, R1 is -CI x is 1, A is -C(O)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- gR9up, R8 is -CF3, and R9, is -H. In another embodiment, the carbon atom to which the R3 gR9up is attached has the R configuration. In another embodiment, the carbon atom to which the R3 gR9up is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; R9 is -CI, -Br, or -I x is 1; A is -C(0)-N(R4)-; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- gR9up; R8 is -H; and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 gR9up is attached has the R configuration. In another embodiment, the carbon atom to which the R3 gR9up is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, - is -CI, x is 1, A is -C(O)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- gR9up, R8 is -H, and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 gR9up is attached has the R configuration. In another embodiment, the carbon atom to which the R3 gR9up is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; - is -CI, -Br, or -I; x is 1; A is -C(0)-N(R4)-; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- gR9up; R8 is -OCH2CH3; and R9 is -H. hi another embodiment, the carbon atom to which the R3 gR9up is attached has the R configuration. In another embodiment, the carbon atom to which the R3 gR9up is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, - is -CI, x is 1, A is -C(O)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- gR9up, R8 is -OCH2CH3, and R9 is -H. In another embodiment, the carbon atom to which the R3 gR9up is attached has the R configuration. In another embodiment, the carbon atom to which the R3 gR9up is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, Rx is -CH3, x is 1, A is -C(O)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- gR9up, and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 gR9up is attached has the R configuration. In another embodiment, the carbon atom to which the R3 gR9up is attached has the S configuration.

In another embodiment, n and p are 0, m is 1, - is -CH3, x is 1, A is -C(0)-R4)- R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen tached to the -C(0)-N(R4)- gR9up, R8 is -H, and R9 is -halo. In another embodiment R9 is "1. In another embodiment, R9 is-Br, In another embodiment, R9 is -F. In another nbodiment, the carbon atom to which the R3 gR9up is attached has the R configuration. In lother embodiment, the carbon atom to which the R3 gR9up is attached has the S mfiguration.
In another embodiment, n and p are 0, m is 1, R, is -CH3, x is 1, A is -C(O)-f(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen ttached to the -C(0)-N(R4)- gR9up, R8 is -halo, and R9 is -H. In another embodiment R8 is CI. In another embodiment, Rg is-Br. In another embodiment, R8 is -F. In another mbodiment, the carbon atom to which the R3 gR9up is attached has the R configuration. In mother embodiment, the carbon atom to which the R3 gR9up is attached has the S ;onfiguration.
In another embodiment, n and p are 0, m is 1, - is -CH3, x is 1, A is -C(O)-ST(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- gR9up, R8 is -H, and R9 is -CH3. In another embodiment, the carbon atom to which the R3 gR9up is attached has the R configuration. In another embodiment, the carbon atom to which the R3 gR9up is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, - is -CH3 x is 1, A is -C(O)-N^)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- gR9up, Rg is -CH3, and R9 is -H. In another embodiment, the carbon atom to which the R3 gR9up is attached has the R configuration. In another embodiment, the carbon atom to which the R3 gR9up is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, Rt is -CH3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)~N(R4)- gR9up, R8 is -H, and R9 is -CF3. In another embodiment, the carbon atom to which the R3 gR9up is attached has the R configuration. In another embodiment, the carbon atom to which the R3 gR9up is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, - is -CH3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen

tached to the -C(0)-N(R4)- gR9up, R8 is -CF3, and R9 is -H. In another embodiment, the arbon atom to which the R3 gR9up is attached has the R configuration. In another cnbodiment, the carbon atom to which the R3 gR9up is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, Kx is -CH3, x is 1, A is -C(O)-I(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen ttached to the -C(0)-N(R4)- gR9up, R8 is -H, and R In another embodiment, n and p are 0, m is 1, R, is -CH3, x is 1, A is -C(O)-^(R4)-5 R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen ittached to the -C(0)-N(R4)- gR9up, R8 is -OCH2CH3, and R9 is -H. In another embodiment, he carbon atom to which the R3 gR9up is attached has the R configuration. In another embodiment, the carbon atom to which the R3 gR9up is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, Rl is -CF3, x is 1, A is -C(O)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- gR9up, and R8 and Rg are -H. In another embodiment, the carbon atom to which the R3 gR9up is attached has the R configuration. In another embodiment, the carbon atom to which the R3 gR9up is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, - is -CF3, x is 1, A is -C(O)-NCR9)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- gR9up, R8 is -H, and Rg is -halo. In another embodiment R9 is -CI. In another embodiment, R9 is -Br. In another embodiment, R? is -F. In another embodiment, the carbon atom to which the R3 gR9up is attached has the R configuration. In another embodiment, the carbon atom to which the R3 gR9up is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, Rt is -CF3, x is 1, A is -C(O)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- gR9up, R8 is -halo, and R9 is -H. In another embodiment R8 is -CI. In another embodiment, R8 is -Br. In another embodiment, R8 is -F. In another embodiment, the carbon atom to which the R3 gR9up is attached has the R configuration. In

another -embodiment, the carbon atom to which the R3 gR9up is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, Rx is -CF3, x is 1, A is -C(O)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- gR9up, Rg is -H, and R9 is -CH3. In another embodiment, the carbon atom to which the R3 gR9up is attached has the R configuration. In another embodiment, the carbon atom to which the R3 gR9up is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, Rx is -CF3, x is 1, A is -C(O)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- gR9up, R8 is -CH3, and R9 is -H. In another embodiment, the carbon atom to which the R3 gR9up is attached has the R configuration. In another embodiment, the carbon atom to which the R3 gR9up is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, R: is -CF3, x is 1, A is -C(O)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- gR9up, R8 is -H, and R9 is -CF3. In another embodiment, the carbon atom to which the R3 gR9up is attached has the R configuration.
In another embodiment, n and p are 0, in is 1, R, is -CF3, x is 1, A is -C(O)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- gR9up, R8 is -CF3, and R9 is -H. In another embodiment, the carbon atom to which the R3 gR9up is attached has the R configuration. In another embodiment, the carbon atom to which the R3 gR9up is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, R1 is -CF3, x is 1, A is -C(O)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4> gR9up, R8 is -H, and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 gR9up is attached has the R configuration. In another embodiment, the carbon atom to which the R3 gR9up is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, - is -CF3, x is 1, A is -C(O)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4> gR9up, R8 is -OCH2CH3, and R9 is -H. In another embodiment, the carbon atom to which the R3 gR9up is attached has the R configuration. In another embodiment, the carbon atom to which the R3 gR9up is attached has the S configuration.

In another embodiment, n and p are 0; m is 1; R! is -CI, -Br, or -I; x is 1; A is C(0)-N(R4)s R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached o the -C(0)-N(R4)- gR9up; R4 is -H; RS is -tot-butyl; and R9 is -H. In another embodiment, he carbon atom to which the R3 gR9up is attached has the R configuration. In another embodiment, the carbon atom to which the R3 gR9up is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, Rx is -CI, x is 1, A is -C(O)-ISF(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- gR9up, R4 is -H, R8 is -tert-butyl, and I^ is -H. In another embodiment, the carbon atom to which the R3 gR9up is attached has the R configuration. In another embodiment, the carbon atom to which the R3 gR9up is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; Kx is -CI, -Br, or -I; x is 1; A is -C(0)-N(R4)-; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- gR9up; R4 is -H; R8 is -H; and R9 is -tert-butyl. In another embodiment, the carbon atom to which the R3 gR9up is attached has the R configuration. In another embodiment, the carbon atom to which the R3 gR9up is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, - is -CI, x is 1, A is -C(O)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- gR9up, R4 is -H, R8 is -H, and R, is -tert-butyl. In another embodiment, the carbon atom to which the R3 gR9up is attached has the R configuration. In another embodiment, the carbon atom to which the R3 gR9up is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, Rx is -CH3, x is 1, A is -C(O)-NR4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- gR9up, R4 is -H, R8 is -tert-butyl, and R9 is -H. In another embodiment, the carbon atom to which the R3 gR9up is attached has the R configuration. In another embodiment, the carbon atom to which the R3 gR9up is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, Rx is -CH3, x is 1, A is -C(O)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- gR9up, R4 is -H, R8 is -H, and R9 is -tert-butyl. In another embodiment, the carbon atom to which the R3 gR9up is attached has the R configuration. In another embodiment, the carbon atom to which the R3 gR9up is attached has the S configuration.

In another embodiment, n and p are 0, m is 1, Rx is -CH3, x is 1, A is -C(O)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitgen attached to the -C(0)-N(R4)- group, R4 is -H, Rg is -CH3, and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n, p, and m are 0; R, is -CI, -Br, or, -I; x is 0; R4 is -H; and R8 and R9 are -H,
In another embodiment, n, p, and m are 0; R9 is -CI. x is 0; R4 is -H; and R8 and R9 are -H.
In another embodiment, n, p, and m are 0; R9 is -CI, -Br, or, -I; x is 0; R4 is -H; R8 is -H; and R9is -halo. In another embodiment, R9 is -CI. In another embodiment, R9 is -Br. In another embodiment, R9 is -F.
In another embodiment, n, p, and m are 0; Rt is -CI; x is 0; R9 is -H; R8 is -H; and R9 is -halo. In another embodiment, Rg is -CI. In another embodiment, R9 is -Br. In another embodiment, R9 is -F.
In another embodiment, n, p, and m are 0; - is -CI, -Br, or, -I. x is 0; R4 is -H; R8 is -halo; and R9 is -H. In another embodiment, R8 is -CI. In another embodiment, R8 is -Br. In another embodiment, R8 is -F.
In another embodiment, n, p, and m are 0; R9 is -CI; x is 0; R4 is -H; R8 is -halo; and R9 is -H. In another embodiment, R8 is -CI. In another embodiment, R8 is -Br. In another embodiment, R8 is -F.
In another embodiment, n, p, and m are 0; - is -CI, -Br, or, -L x is 0; R4 is -H; R8 is -H; and Rg is -CH3.
In another embodiment, n, p, and m are 0; R9 is -CI; x is 0; R4 is -H; R8 is -H; and R9 is -CH3.
In another embodiment, n, p, and m are 0; R, is -CI, -Br, or, -I; x is 0; R4 is -H; R8 is -CH3; and R9 is -H.
In another embodiment, n, p, and m are 0; - is -CI; x is 0; R4 is -H; R8 is -CH3; and R9 is -H.
In another embodiment, n, p, and m are 0; - is -CI, -Br, or, -I; x is 0; R4 is -H; R8 is -H; andR9is -CF3.

In another embodiment, n, p, and m are 0;R9is -CI; x is 0; R4 is -H; R8 is -H; and R9 is -CF3.
In another embodiment, n, p, and m are 0; R, is -CI, -Br, or, -I; x is 0; R4 is -H; R8 is -CF3; and R9 is -H.
In another embodiment, n, p, and m are 0; - is -CI; x is 0; R4 is -H; R8 is -CF3; and R9 is -H.
In another embodiment, n, p, and m are 0; R! is -CI, -Br, or, -I; x is 0; R4 is -H; R8 is -H; and R, is -OCH2CH3.
In another embodiment, n, p, and m are 0; R, is -CI; x is 0; R4 is -H; R8 is -H; and R is -OCH2CH3.
In another embodiment, n, p, and m are 0; R, is -CI, -Br, or, -I; x is 0; R4 is -H; R8 is -OCH2CH3; and R, is -H.
In another embodiment, n, p, and m are 0; - is -CI; x is 0; R4 is -H; R8 is -OCH2CH3; and R9 is -H.
In another embodiment, n, p, and m are 0; R, is -CH3; x is 0; R4 is -H; and R8 and R*) are -H.
In another embodiment, n, p, and m are 0; R, is -CH3; x is 0; R4 is -H; R8 is -H; and R9 is -halo. In another embodiment, 11$ is -CI. In another embodiment, R9 is -Br. In another embodiment, R9 is -F.
In another embodiment, n, p, and m are 0; Ri is -CH3; x is 0; R4 is -H; Rg is -halo; and R9 is -H. In another embodiment, R8is-Cl. In another embodiment, R8 is-Br. In another embodiment, R8 is -F.
In another embodiment, n, p, and m are 0; - is -CH3; x is 0; R4 is -H; R8 is -H; and Rg is -CH3.
In another embodiment, n, p, and m are 0; Rx is -CH3; x is 0; R4 is -H; R8 is -CH^andRgis-H.
Li another embodiment, n, p, and m are 0; Rx is -CH3; x is 0; R4 is -H; R8 is -H; and R, is -CF3.
In another embodiment, n, p, and m are 0; - is -CH3; x is 0; R4 is -H; R8 is -CF3; and R9 is -H.
In another embodiment, n, p, and m are 0; R, is -CH3; x is 0; R4 is -H; R8 is

H; and R9 is -OCH2CH3.
In another embodiment, n, p, and m are 0, R9 is -CH3; x is 0; R4 is -H; R8 is OCH2CH3; and R9 is -H.
In another embodiment, n, p, and m are 0; Rx is -CF3; x is 0; R4 is -H; and R8 md R9 are -H.
In another embodiment, n, p, and m are 0; - is -CF3; x is 0; R4 is -H; R8 is -H; and R9 is-halo. In another embodiment, R? is -CI. In another embodiment, R9 is-Br. In mother embodiment, R9 is -F.
In another embodiment, n, p, and m are 0; - is -CF3; x is 0; R4 is -H; R8 is -halo; and R9 is -H. In another embodiment, R8 is -CI. In another embodiment, R8 is -Br. In another embodiment, Rg is -F.
In another embodiment, n, p, and m are 0, - is -CF3; x is 0; is -H; R8 is -H; and R9 is -CH3.
In another embodiment, n, p, and m are 0; R, is -CF3; x is 0; R4 is -H; R8 is -CH3; and R9, is -H.
In another embodiment, n, p, and m are 0; R, is -CF3; x is 0; R4 is -H; R8 is -H; and R9 is -CF3.
In another embodiment, n, p, and m are 0; Rl is -CF3; x is 0; R4 is -H; R8 is -CF3; and R9 is -H.
In another embodiment, n, p, and m are 0; R9is -CF3; x is 0; R4 is -H; R8 is -H; and R In another embodiment, n, p, and m are 0; - is -CF3; x is 0; R4 is -H; R8 is -OCH2CH3; and R In another embodiment, n, p, and m are 0; - is -CI, -Br, or, -I; x is 0; R4 is -H; R8 is -tert-butyl; and 1^ is -H.
In another embodiment, n, p, and m are 0;R9 is -CI; x is 0; R4 is -H; R8 is -tert-butyl; and R9 is -H.
In another embodiment, n, p, and m are 0;R9 is -CI, -Br, or, -I; x is 0; R4 is -H; R8 is -H; and R9 is -tert-butyl.
In another embodiment, n, p, and m are 0; Rt is -CI; x is 0; R4 is -H; R8 is -H; and R9 is -tert-butyl.

In another embodiment, n, p, and m are 0; R9 is -CH3; x is 0; R4 is -H; R8 is erf-butyl; and R9 is -H.
In another embodiment, n, p, and m are 0;R9 is -CH3; x is 0; R4 is -H; R8 is i; andR9 is -terf-butyl.
In another embodiment, n, p, and m are 0; R9 is -CH3; x is 0; R4 is -H; R8 is 3H3; and R9 is -CH3.
In another embodiment, n and p are 0; m is 1; Rx is -CI, -Br, or -I; x is 0; R4 is H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the ►enzothiazolyl group; and R8 and R9 are -H. In another embodiment, the carbon atom to vhich the R3 group is attached has the R configuration. In another embodiment the carbon itom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; - is -CI; x is 0; R4 is -H; R3 is CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group; and R8 and R9are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; Rx is -CI, -Br, or -I; x is 0; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group; R8 is -H; and R9is -halo. In another embodiment R9 is -CI. In another embodiment, Rg is -Br. In another embodiment, R9 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, - is -CI, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R8 is -H, and R9 is -halo. In another embodiment Rg is -CI. In another embodiment, R9 is -Br. In another embodiment, R9is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; R9is -CI, -Br, or -I; x is 0; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group; R8 is -halo; and R9 is -H. In another embodiment R8 is -CI. In another

nbodiment, R8 is -Br. In another embodiment, R8 is -F. In another embodiment, the trbon atom to which the R3 group is attached has the R configuration. In another nbodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, Rx is -CI, x is 0, R4 is -H, R3 is 3H3 and is attached to the carbon atom adjacent to the nitR9gen attached to the enzothiazolyl group, R8 is -halo, and is -H, In another embodiment R8 is -CI. In another tnbodiment, R8 is -Br. In another embodiment, R8 is -F. In another embodiment, the arbon atom to which the R3 group is attached has the R configuration. In another mbodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; - is -CI, -Br, or -I; x is 0; R4 is H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the >enzothiazolyl group; R8 is -H; and R9 is -CH3. In another embodiment, the carbon atom to vhich the R3 group is attached has the R configuration.
In another embodiment, n and p are 0, m is 1, - is -CI, x is 0, R4 is -H, R3 is CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to theenzothiazolyl group, R8 is -H, and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration.
In another embodiment, n and p are 0; m is 1; Kx is -CI, -Br, or -I; x is 0; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group; R8 is -CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, - is -CI, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R8 is -CH3, and 1^ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; R, is -CI, -Br, or -I; x is 0; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group; R8 is -H; and is -CF3. In another embodiment, the carbon atom to

which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, - is -CI, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R8 is -H, and R is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; Rt is -CI, -Br, or -I; x is 0; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group; R8 is -CF3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, R, is -CI, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, Rs is -CF3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; Rx is -CI, -Br, or -I; x is 0; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group; R8 is -H; and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, Rx is -CI, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R8 is -H, and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; - is -CI, -Br, or -I; x is 0; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group; R8 is -OCH2CH3; and R
atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, R} is -CI, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R8 is -OCH2CH3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, R! is -CH3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, Rx is -CH3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached .to the benzothiazolyl group, Rg is -H, and R9 is -halo. In another embodiment R9 is -CI. In another embodiment, R9 is -Br. In another embodiment, R9 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 6, m is 1, - is -CH3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R8 is -halo, and R9 is -H. In another embodiment R8 is -CI. In another embodiment, R8 is -Br. In another embodiment, R8 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, - is -CH3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R8 is -H, and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, R, is -CH3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the

benzothiazolyl group, R8 is -CH3, and R*, is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p axe 0, m is 1, Rx is -CH3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R8 is -H, and R** is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, R! is -CH3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R8 is -CF3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, - is -CH3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R8 is -H, and R9 is -OCH2CH3. hi another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, Rx is -CH3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, Rg is -OCH2CH3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, Rt is -CF3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, and Rg and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, R9 is -CF3, x is 0, R4 is -H, R3 is 1 -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R8 is -H, and R9 is -halo. In another embodiment R9 is -CI. In another

embodiment, R9is -Br. In another embodiment, R9is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, - is -CF3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R8 is -halo, and R9 is -H. In another embodiment R8 is -CI. In another embodiment, R8 is -Br. In another embodiment, R9is ~F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, R5 is -CF3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R8 is -H, and R9is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, R, is -CF3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, Rs is -CH3, and R9is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, Rt is -CF3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R8 is -H, and R9is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, - is -CF3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R8 is -CF3, and R9is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, R, is -CF3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the

aizothiazolyl group, R8 is -H, and R9 is -OCH2CH3. In another embodiment, the carbon om to which the R3 group is attached has the R configuration. In another embodiment, the urbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, - is -CF3, x is 0, R4 is -H, R3 is 3H3 and is attached to the carbon atom adjacent to the nitR9gen attached to the enzothiazolyl group, R8 is -OCH2CH3, and R9 is -H. In another embodiment, the carbon torn to which the R3 group is attached has the R configuration. In another embodiment, the arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; Rx is -CI, -Br, or -I; x is 0; R3 is CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the >enzothiazolyl group; R4 is -H; R8 is -tert-butyl; and R9 is -H. In another embodiment, the :arbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, - is -CI, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R4 is -H, R9is -ter/-butyl, and - is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; Rt is -CI, -Br, or, -I; x is 0; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group; R4 is -H; R8 is -H; and K^ is -tert-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, R, is -CI, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R4 is -H, R9is -H, and R9 is -tert-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, R9 is -CH3, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R4 is -H, R9is -tert-butyl, and R9 is -H. In another embodiment, the carbon atom to which the

R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, - is -CH3, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R4 is -H, R8 is -H, and R9is -tert-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, R9: is -CH3, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R4 is -H, R8 is -CH3, and R9is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; m is 1; Rx is -CH3, -CI, -Br, or -I; x is 1; A is -C(0)-N(R4)-; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group; R4 is -H; R8 is -H; and R9 is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, A- is a pyridyl group, n is 0, m is 1, Rt is -CH3, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R4 is -H, R8 is -H, and R9 is -Cl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group; n is 0; m is 1; - is -Cl, -Br, or -I; x is 1; A is -C(0)-N(R4)-; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group; R4 is -H; R8 is -H; and R9is -Br. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0, m is 1, Rx is -Cl, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen

ittached to the ~C(0)-N(R4)- group, R4 is -H, R8 is -H, and R9 is -Br. In another embodiment, he carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group, n is 0, m is 1, R9 is -CH3, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R4 is -H, R8 is -H, and is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is apyrimidinyl group; p is 0; m is 1; - is -CH3, -CI, -Br, or -I; x is 1; A is -C(0)-N(R4)-; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group; R4 is -H; R8 is -H; and R9 is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar is a pyrimidinyl group, p is 0, m is 1, Rx is -CH3, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R4 is -H, R8 is -H, and R9 is -Cl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar is a pyrimidinyl group; p is 0; m is 1; - is -Cl, -Br, or -I; x is 1; A is -C(0)-N(R4)-; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group; R4 is -H; R8 is -H; and R9 is -Br. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyrimidinyl group, p is 0, m is 1, R2 is -Cl, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C^-N^)- group, R4 is -H, R8 is -H, and R9 is -Br. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Axx is a pyrimidinyl group, p is 0, m is 1, - is -CH3, x is 1, A is -QCO-NCR9-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R4 is -H, R8 is -H, and R In another embodiment, A- is a pyridyl group; n is 0; m is 1; Ra is -CH3, -CI, «Br, or -I; x is 0; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group; R4 is -H; R8 is -H; and R, is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group, n is 0, m is 1, Rt is -CH3, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R4 is -H, R8 is -H, and R9 is -CI. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group; n is 0; m is 1; Kx is -CI, -Br, or -I; x is 0; R3 is -CH3 and is attached to the carbon atom adjacent to the mtR9gen attached to the benzothiazolyl group; R4 is -H; R8 is -H; and R9 is -Br. In another embodiment, the ' carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0, m is 1, Rx is -CI, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R4 is -H, R8 is -H, and B^ is -Br. Li another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Art is a pyridyl group, n is 0, m is 1, Kx is -CH3, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R4 is -H, R8 is -H, and is -F. In another embodiment, the carbon > atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Axx is a pyrimidinyl group; p is 0; m is 1; Rt is -CH3, HI, -Br, or -I; x is 0; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen ttached to the benzothiazolyl group; R4 is -H; R8 is -H; and R9 is -halo. In another mbodiment, the carbon atom to which the R3 group is attached has the R configuration. In nother embodiment, the carbon atom to which the R3 group is attached has the S onfiguration.
In another embodiment, Axx is a pyrimidinyl group, p is 0, m is 1, R, is -CH3, x s 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the >enzothiazolyl group, R4 is -H, R8 is -H, and R? is -CI. In another embodiment, the carbon ttom to which the R3 group is attached has the R configuration. In another embodiment, the :arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group; p is 0; m is 1; Rt is -CI, •Br, or -I; x is 0; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen ittached to the benzothiazolyl group; R4 is -H; R9is -H; and R9 is -Br. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Art is a pyrimidinyl group, p is 0, m is 1, - is -CI, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R4 is -H, R8 is -H, and R9 is -Br. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar; is a pyrimidinyl group, p is 0, m is 1, Rt is -CH3, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R4 is -H, R8 is -H, and T^ is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, m is 1 and R3 is -(CrC4)alkyl and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- when x is 1 or the benzothiazolyl group when x is 0. In another embodiment, m is 1 and R3 is -(CrC4)alkyl and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- when x is

or the benzothiazolyl group when x is 0 and the carbon to which the R3 group is attached is L the R configuration.
In another embodiment, m is 1 and R3 is -CH3 and is attached to the carbon torn adjacent to the nitR9gen attached to the -C(0)-N(R4)- when x is 1 or the benzothiazolyl R9up when x is 0. In another embodiment, m is 1 and R3 is -CH3 and is attached to the arbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- when x is 1 or the enzothiazolyl group when x is 0 and the carbon to which the R3 group is attached is in the R onfiguration.
In another embodiment, m is 1 and R3 is -(CrC4)alkyl and is attached to the ;arbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- when x is 1 or the )enzothiazolyl group when x is 0, In another embodiment, m is 1 and R3 is -(CrC4)alkyl and s attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- when x is L or the benzothiazolyl group when x is 0 and the carbon to which the R3 group is attached is m the S configuration.
In another embodiment, m is 1 and R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- when x is 1 or the benzothiazolyl group when x is 0. In another embodiment, m is 1 and R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- when x is 1 or the benzothiazolyl group when x is 0 and the carbon to which the R3 group is attached is in the S configuration.
In another embodiment, m is 1 and R3 is -(Cj-C^alkyl and is attached to the carbon atom adjacent to the nitR9gen attached to the pyridyl group or pyrimidinyl group. In another embodiment, m is 1 and R3 is -(CrC4)alkyl and is attached to the carbon atom adjacent to the mtR9gen attached to the pyridyl group or pyrimidinyl group and the carbon to which the R3 group is attached is in the R configuration.
In another embodiment, m is 1 and R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the pyridyl group or pyrimidinyl group. In another embodiment, m is 1 and R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the pyridyl group or pyrimidinyl group and the carbon to which the R3 group is attached is in the R configuration.

In another embodiment, m is 1 and R3 is -(CrC4)alkyl and is attached to the arbon atom adjacent to the nitR9gen attached to the pyridyl group or pyrimidinyl group. In nother embodiment, m is 1 and R3 is -(CrC4)alkyl and is attached to the carbon atom djacent to the nitR9gen attached to the pyridyl group or pyrimidinyl group and the carbon to /hich the R3 group is attached is in the S configuration.
In another embodiment, m is 1 and R3 is -CH3 and is attached to the carbon torn adjacent to the nitR9gen attached to the pyridyl group or pyrimidinyl group. In another embodiment, m is 1 and R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen ittached to the pyridyl group or pyrimidinyl group and the carbon to which the R3 group is ittached is in the S configuration.

and pharmaceutically acceptable salts thereof, where Arl9 R3, R8, R9 A, x, and m, are defined above for the Benzoazolylpiperazine Compounds of formula (lb).
In one embodiment, Axx is a pyrazinyl group.
In another embodiment, Ar, is a pyridazinyl group.
In another embodiment, Ar1 is a thiazanyl group.
In another embodiment, x is 1 and A is -C(0)-N(R4)-.
In another embodiment, x is 1 and A is -C(S)-N(R4)-.

In another embodiment x is 0. In another embodiment, p is 0. In another embodiment, p is 1. In another embodiment, m is 0. In another embodiment, m is 1. In another embodiment, R4 is -H. In another embodiment, R4 is -(C1-C6)alkyl.
In another embodiment, Ar1 is a pyrazinyl group, x is 1, and A is -C(0)N(R4)-. In another embodiment, A1 is a pyrazinyl group, x is 1, and A is -C(S)N(R4)-. In another embodiment, Ar1 is a pyridazinyl group, x is 1, and A is -C(0)N(R4)-.
In another embodiment, Ar1 is a pyridazinyl group, x is 1, and A is -
C(S)N(R4)-.
In another embodiment, Ar1 is a thiazanyl group, x is 1, and A is -C(0)N(R4)-.
In another embodiment, Ar1 is a thiazanyl group, x is 1, and A is -C(S)N(R4)-.
In another embodiment, Rt is -H.
In another embodiment, - is -CI.
In another embodiment, Kx is -Br.
In another embodiment, - is -I.
In another embodiment, - is -F.
In another embodiment, - is -(Q-C^alkyl.
In another embodiment, R1 is -CH3.
In another embodiment, R1 is -N02.
In another embodiment, R1 is -CN.
In another embodiment, R1 is -OH.
In another embodiment, - is -OCH3.
Li another embodiment, - is -NH2.
Li another embodiment, - is -C(halo)3.
Li another embodiment, is -CH(halo)2.
Li another embodiment, R9 is -CH2(halo).
Li another embodiment, p is 1 and R2 is -halo, -CN, -OH, -0(C1-C6)alkyl,









In another embodiment, p is 0, m is 1, Rt is -CI, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R5 is -halo, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -H, and R9 is -halo. In another embodiment, R9 is -Cl. In another embodiment, R9 is -Br. In another embodiment, R9 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, Ri is -Cl, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -H, and R9 is -halo. In another embodiment, R? is -Cl. In another embodiment, R9 is -Br. In another embodiment, is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -halo, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -halo, and R? is -H. In another embodiment, R8 is-CL In another embodiment, R8 is -Br. In another embodiment, R8 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, Rx is -Cl, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R9is -halo, and R9 is -H. In another embodiment, R8 is -Cl. In another embodiment, R8 is -Br. In another embodiment, R8 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, Rx is -halo, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the

-C(0>N(R4> group, R8 is -H, and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, Rx is -CI, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -H, and R hi another embodiment, p is 0, m is 1, - is -halo, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -CH3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CI, x is 1, A is -C(0)-N(R4)-, R4 3 -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the C(0)-N(R4)- group, R8 is -CH3, and R9 is -H. In another embodiment, the carbon atom to vhich the R3 group is attached has the R configuration. In another embodiment, the carbon itom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, Rx is -halo, x is 1, A is -C(0)-N(R4)-, R4 Is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -H, and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CI, x is 1, A is -C(0)-N(R4>, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -H, and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, Rx is -halo, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the

:(0)-N(R4)- group, R9is -CF3, and R9 is -H. In another embodiment, the carbon atom to Inch the R3 group is attached has the R configuration. In another embodiment, the carbon torn to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, Rx is -CI, x is 1, A is -C(0)-N(R4)-, R4 > -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the C(0)-N(R4)- group, R8 is -CF3, and R9, is -H. In another embodiment, the carbon atom to /hich the R3 group is attached has the R configuration. In another embodiment, the carbon torn to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, Ra is -halo, x is 1, A is -C^-NQ^)-, R4 s -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the C(0)-N(R4)- group, R8 is -H, and R9is -OCH2CH3. In another embodiment, the carbon atom o which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, Rx is -CI, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the ■C(0)-N(R4)- group, R8 is -H, and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, Kx is -halo, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -OCH2CH3, and R9is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CI, x is 1, A is -C(0)-N(R4)-, R4 is -H? R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R9is -OCH2CH3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -CH3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the

(0)-N(R4)- group, and R8 and R9 are -H. In another embodiment, the carbon atom to which s R3 group is attached has the R configuration. In another embodiment, the carbon atom to lich the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CH3, x is 1, A is -C(0)-N(R4)-, R4 -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the XO)-N(R4)- group, R8 is -H, and R9> is -halo. In another embodiment Rc> is -CI. In another nbodiment, R9 is -Br. In another embodiment, R9 is -F. In another embodiment, the carbon ;om to which the R3 group is attached has the R configuration. In another embodiment, the arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CH3, x is 1, A is -C(0)-N(R4>, R4 > -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the C(0)-N(R4)- group, R8 is -halo, and is -H. In another embodiment R8 is -Cl. In another mbodiment, R8 is -Br. In another embodiment, R8 is -F. In another embodiment, the carbon torn to which the R3 group is attached has the R configuration. In another embodiment, the ;arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CH3, x is 1, A is -C(0)-N(R4)-, R4 s -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the ■C(0)-N(R4)- group, R8 is -H, and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -CH3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -CH3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, Kx is -CH3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -H, and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, p is 0, m is 1, Rt is -CH3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4> group, R9is -CF3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, Rt is -CH3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -H, and R,, is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -CH3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -OCH2CH3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CF3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CF3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -H, and R9is -halo. In another embodiment R9 is -Cl. In another embodiment, R9is -Br. In another embodiment, R9, is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, Rt is -CF3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -halo, and R9is -H. In another embodiment R8 is -Cl. In another embodiment, R8 is -Br. In another embodiment, R8 is -F. In another embodiment, the carbon

atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CF3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4 group, R8 is -H, and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CF3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -CH3, and R9» is -H, In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CF3» x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -H, and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, Rl is -CF3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the ~C(0)-N(R4)- group, R8 is -CF3, and R9, is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CF3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -H, and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
La another embodiment, p is 0, m is 1, R, is -CF3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the

-C(0)-N(R4)- group, R8 is -OCH2CH3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -halo, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(O)-N(R4)- group, R4 is -H, R8 is -tot-butyl, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R} is -CI, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(O)-N(R4)- group, R4 is -H, R8 is -tot-butyl, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
hi another embodiment, p is 0, m is 1, Rt is -halo, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(O)-N(R4)- group, R4 is -H, R8 is -H, and R9 is -tot-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CI, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(O)-N(R4)- group, R4 is -H, R8 is -H, and 1^ is -tot-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, RK is -CH3, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(O)-N(R4)- group, R4 is -H, R8 is -tot-butyl, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, Kx is -CH3, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(O)-N(R4)- group, R4 is -H, R8 is -H, and R9, is -tot-butyl. In another embodiment, the carbon

ttom to which the R3 group is attached has the R configuration. In another embodiment, the ;arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CH3, x is 1, A is -C(0)-N(R4)-, R3 s -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(O)-M(R4)- group, R4 is -H, R8 is »CH3, and R9is -CH3. In another embodiment, the carbon atom ;o which the R3 group is attached has the R configuration. In another embodiment, the sarbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p and m are 0, - is -halo x is 0, R4 is -H, and R8 and R9are -H.
In another embodiment, p and m are 0, R, is -CI x is 0, R4 is -H, and R8 and R9are-H.
In another embodiment, p and m are 0, R9 is -halo x is 0, R4 is -H, R9is -H, and R9 is-halo. In another embodiment, R9is-CI. In another embodiment, R9is-Br. In another embodiment, R9is -F.
In another embodiment, p and m are 0, - is -Cl( x is 0, R4 is -H, R8 is -H, and R9is -halo. In another embodiment, R9is -CI. In another embodiment, R9is -Br. In another embodiment, R9is -F.
In another embodiment, p and m are 0, - is -halo, x is 0, R4 is -H, R8 is -halo, and R9is -H. In another embodiment, R8 is -CI. In another embodiment, R8 is -Br. In another embodiment, R8 is -F.
In another embodiment, p and m are 0, - is -CI, x is 0, R4 is -H, R8 is -halo, and R9is -H. In another embodiment, R8 is -CI. In another embodiment, R8 is -Br. In another embodiment, R8 is -F.
In another embodiment, p and m are 0, R1 is -halo, x is 0, R4 is -H, Rs is -H, and R9is -CH3.
In another embodiment, p and m are 0, R1 is -CI, x is 0, R4 is -H, R8 is -H, and R9is -CH3.
In another embodiment, p and m are 0, R! is -halo, x is 0, R4 is -H, R8 is -CH3, and R9is ~H.
In another embodiment, p and m are 0, - is -CI, x is 0, R4 is -H, R8 is -CH3? and R9is -H.

In another embodiment, p and m are 0, R1 is -halo, x is 0, R4 is -H, R8 is -H, rid R9 is -CF3.
In another embodiment, p and m are 0, R1 is -CI, x is 0, R9 is -H, R8 is -H, and L9 is -CF3.
In another embodiment, p and m are 0, R1 is -halo, x is 0, R4 is -H, R8 is -CF3, nd R9 is -H.
In another embodiment, p and m are 0, R1 is -CI, x is 0, R4 is -H, R8 is -CF3, nd 1*9 is -H.
In another embodiment, p and m are 0, R1 is -halo, x is 0, R4 is -H, R8 is -H, ndR9,is-C)CH2CH3.
In another embodiment, p and m are 0, R1 is -CI, x is 0, R4 is -H, R8 is -H, and *9 is -OCH2CH3.
In another embodiment, p and m are 0, R1 is -halo, x is 0, R4 is -H, R9is OCH2CH3, and R9» is -H.
In another embodiment, p and m are 0, - is -CI, x is 0, R4 is -H, R8 is OCH2CH3, and R, is -H.
In another embodiment, p and m are 0, - is -CH3, x is 0, R4 is -H, and R8 and l? are -H.
In another embodiment, p and m are 0, - is -CH3, x is 0, R4 is -H, R8 is -H, and R9 is -halo. In another embodiment, R9 is -CI. In another embodiment, R9 is -Br. In another embodiment, R9 is -F.
In another embodiment, p and m are 0, R! is -CH3, x is 0, R4 is -H, R8 is -halo, md R9 is -H. In another embodiment, R8 is -CI. In another embodiment, R8 is -Br. In another embodiment, R8 is -F.
In another embodiment, p and m are 0, - is -CH3, x is 0, R4 is -H, R8 is -H, and R9 is -CH3.
In another embodiment, p and m are 0, R1 is -CH3, x is 0, R4 is -H, R8 is -CH3, and R9 is -H.
In another embodiment, p and m are 0, R, is -CH3, x is 0, R4 is -H, R8 is -H, and R, is -CF3.

In another embodiment, p and m are 0, R1 is -CH3, x is 0, R4 is -H, R8 is -CF3, ind R9, is -H.
In another embodiment, p and m are 0, R1 is -CH3, x is 0, R4 is -H, R8 is -H, and R9is -OCH2CH3.
In another embodiment, p and m are 0, - is -CH3, x is 0, R4 is -H, R8 is -OCH2CH3, and R, is -H.
In another embodiment, p and m are 0, Rt is -CF3, x is 0, R4 is -H, and R8 and R9 are -H.
In another embodiment, p and m are 0, R1 is -CF3, x is 0, R4 is -H, R8 is -H, and R9, is -halo. In another embodiment, R9 is-CI. In another embodiment, R9 is-Br. In another embodiment, R9 is -F.
In another embodiment, p and m are 0, R1 is -CF3, x is 0, R4 is -H, R8 is -halo, andR9is-H. In another embodiment, R8 is-CI. In another embodiment, R8 is-Br. In another embodiment, R8 is -F.
hi another embodiment, p and m are 0, R, is -CF3, x is 0, R4 is -H, R8 is -H, and R9 is -CH3.
In another embodiment, p and m are 0, R, is -CF3, x is 0, R4 is -H, R8 is -CH3, and R9 is -H.
In another embodiment, p and m are 0, R1 is -CF3, x is 0, R4 is -H, R8 is -H, and 1*9 is -CF3.
In another embodiment, p and m are 0, R1 is -CF3, x is 0, R9 is -H, R8 is -CF3, and R9 is -H.
Li another embodiment, p and m are 0, R1 is -CF3, x is 0, R4 is -H, R8 is -H, and R» is -OCH2CH3.
In another embodiment, p and m are 0, Rl is -CF3, x is 0, R4 is -H, R8 is -OCH2CH3, and R, is -H.
hi another embodiment, p and m are 0, R1 is -halo, x is 0, R4 is -H, R8 is -tert-butyl, and R9 is -H.
In another embodiment, p and m are 0, R1 is -CI, x is 0, R4 is -H, R8 iserf-butyl, and R9 is -H.

In another embodiment, p and m are 0, - is -halo, x is 0, R4 is -H, R5 is -H, and R9 is -tot-butyl.
In another embodiment, p and m are 0, - is -CI, x is 0, R4 is -H, R8 is -H, and R9 is -tot-butyl.
In another embodiment, p and m are 0, R1 is -CH3, x is 0, R4 is -H, R8 is -tot-butyl, and R9is -H.
In another embodiment, p and m are 0, R, is -CH3 x is 0, R4 is -H, R8 is -H, and R9is -tot-butyl.
In another embodiment, p and m are 0, R1 is -CH3, x is 0, R4 is -H, R8 is -CH3, and R9 is -CH3.
In another embodiment, p is 0, m is 1, R, is -halo, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CI, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, and R8 and R9, are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -halo, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R8 is -H, and R9 is -halo. In another embodiment, R9is -CI. In another embodiment, R9is -Br. In another embodiment, R9 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -CI, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, Rs is -H, and R9is -halo. In another embodiment, R9 is -CI. In another embodiment, R9is

-Br. In another embodiment, R9 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -halo, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R8 is -halo, and R9 is -H. In another embodiment, R8 is -CI. In another embodiment, R8 is -Br. In another embodiment, R8 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CI, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R8 is -halo, and R9 is -H. In another embodiment, R8 is -CL In another embodiment, R8 is -Br. In another embodiment, R8 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -halo, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R8 is -H, and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CI, x is 0, R9 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R8 is -H, and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -halo, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R8 is -CH3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, p is 0, m is 1, R1 is -CI, x is 0, R4 is -H, R3 is -CH3 and s attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R-8 is -CH3, and R9, is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R{ is -halo, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R8 is -H, and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R5 is -CI, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R9is -H, and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -halo, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R8 is -CF3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -CI, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R8 is -CF3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has.the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -halo, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R8 is -H, and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, p is 0, m is 1, R, is -CI, x is 0, R4 is -H, R3 is -CH3 and s attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, i8 is -H, and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 jR9up is attached has the R configuration. In another embodiment, the carbon atom to which he R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, Rt is -halo, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R8 is -OCH2CH3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CI, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R8 is -OCH2CH3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CH3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, and R9and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, Rl is -CH3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R8 is -H, and R9 is -halo. In another embodiment R9 is -CI. In another embodiment, R9 is -Br. In another embodiment, R9 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CH3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R8 is -halo, and R9 is -H. In another embodiment R8 is -CI. In another embodiment, R8 is -Br. In another embodiment, R8 is -F. In another embodiment, the carbon atom to

which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CH3, x is 0, R9 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R8 is -H, and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -CH3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R8 is -CH3, and - is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -CH3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R8 is -H, and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CH3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R8 is -CF3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -CH3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R8 is -H, and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CH3, x is 0, R4 is ~H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R8 is -OCH2CH3, and R9 is -H. In another embodiment, the carbon atom to which the

3 group is attached has the R configuration. In another embodiment, the carbon atom to hich the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CF3, x is 0, R4 is -H, R3 is -CH3 id is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl R9up, and R8 and R9» are -EL In another embodiment, the carbon atom to which the R3 group ; attached has the R configuration. In another embodiment, the carbon atom to which the R3 R9up is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -CF3, x is 0, R4 is -H, R3 is -CH3 nd is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl pR9up, R8 is -H, and R9 is -halo. In another embodiment R9 is -CI. In another embodiment, is -Br. In another embodiment, R9 is -F. In another embodiment, the carbon atom to vhich the R3 group is attached has the R configuration. In another embodiment, the carbon itom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CF3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R8 is -halo, and R9 is -H. In another embodiment R8 is -CL In another embodiment, R8 is -Br. In one embodiment, R8 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CF3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R8 is -H, and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R} is -CF3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R8 is -CH3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -CF3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl

R9up, R8 is -H, and R9 is -CF3. In another embodiment, the carbon atom to which the R3 R9up is attached has the R configuration. In another embodiment, the carbon atom to which le R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CF3, x is 0, R4 is -H, R3 is -CH3 nd is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl R9up, Rs is -CF3, and R9 is -H. In another embodiment, the carbon atom to which the R3 ;R9up is attached has the R configuration. In another embodiment, the carbon atom to which he R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CF3, x is 0, R4 is -H, R3 is -CH3 tnd is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl jR9up, Rs is -H, and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the l3 group is attached has the R configuration. In another embodiment, the carbon atom to tfhich the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CF3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R8 is -OCH2CH3, and 1^ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, Kx is -halo, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R4 is -H, R8 is -fer*-butyl, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CI, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R4 is -H, R8 is -tert-butyl, and - is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -halo, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R4 is -H, R8 is -H, and R9 is -tert-butyL In another embodiment, the carbon atom to which the R3

R9up is attached has the R configuration. In another embodiment, the carbon atom to which le R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R9 is -CI, x is 0, R3 is -CH3 and is ttached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R4 s -H, R8 is -H, and R9 is -tert-butyl. In another embodiment, the carbon atom to which the R3 pR9up is attached has the R configuration. In another embodiment, the carbon atom to which he R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CH3, x is 0, R3 is -CH3 and is ittached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R4 is -H, R8 is -terf-butyl, and R9is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, RY is -CH3, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R4 is -H, R8 is -H, and R9 is -terf-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -CH3, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R4 is -H, R8 is -CH3, and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyrazinyl group, p is 0, m is 1, R, is -CH3 or -halo, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R4 is -H, R8 is -H, and I^ is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axj is a pyrazinyl group, p is 0, m is 1, R, is -CH3, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4 group, R4 is -H, R8 is -H, and R9, is -Cl. In another embodiment,

e carbon atom to which the R3 group is attached has the R configuration. In another nbodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyrazinyl group, p is 0, m is 1, - is -halo, x is , A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen rtached to the -C(0)-N(R4)- group, R4 is -H, R8 is -H, and R9 is -Br. In another embodiment, le carbon atom to which the R3 group is attached has the R configuration. In another mbodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ai} is a pyrazinyl group, p is 0, m is 1, R} is -CI, x is , A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen ttached to the -C(0)-N(R4)- group, R4 is -H, R8 is -H, and R9is -Br. In another embodiment, he carbon atom to which the R3 group is attached has the R configuration. In another mbodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aiy is a pyrazinyl group, p is 0, m is 1, R, is -CH3, x is I, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen ittached to the -C(0)-N(R4)- group, R4 is -H, R8 is -H, and R9 is -F. In another embodiment, he carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridazinyl group, p is 0, m is 1, - is -CH3 or -halo, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R4 is -H, R9is -H, and R9 is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyridazinyl group, p is 0, m is 1, R, is -CH3, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)»N(R4)« group, R4 is -H, R8 is -H, and is -CL In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyridazinyl group, p is 0, m is 1, Kx is -halo, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R4 is -H, R9is -H, and R9» is -Br. In another embodiment,

:he carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridazinyl group, p is 0, m is 1, R, is -CI, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R4 is -H, R8 is -H, and R9is -Br. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridazinyl group, p is 0, m is 1, R, is -CH3, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R4 is -H, R8 is -H, and R9 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a thiazanyl group, p is 0, m is 1, R, is -CH3 or -halo, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R4 is -H, R8 is -H, and R9is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a thiazanyl group, p is 0, m is 1, R, is -CH3, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R4 is -H, R8 is -H, and R9is -Cl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a thiazanyl group, p is 0, m is 1, R, is -halo, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)«N(R4)- group, R4 is -H, R8 is -H, and R9is -Br. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a thiazanyl group, p is 0, m is 1, R, is -Cl, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R4 is -H, R8 is -H, and R9is -Br. In another embodiment,

he carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a thiazanyl group, p is 0, m is 1, R, is -CH3, x is 1, A is -C(0)-N(R4, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R4 is -H, R8 is -H, and R9 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyrazinyl group, p is 0, m is 1, R, is -CH3 or -halo, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R4 is -H, R8 is -H, and 1^ is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyrazinyl group, p is 0, m is 1, R, is -CH3, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R4 is -H, Rs is -H, and R9 is -CI. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyrazinyl group, p is 0, m is 1, R, is -halo, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R4 is -H, R9is -H, and R9 is -Br. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyrazinyl group, p is 0, m is 1, R, is -CI, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R4 is -H, R8 is -H, and Rp is -Br. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyrazinyl group, p is 0, m is 1, R, is -CH3, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R4 is -H, R8 is -H, and R9 is -F. In another embodiment, the carbon

atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyridazinyl group, p is 0, m is 1, R1 is -CH3 or -halo, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R4 is -H, R8 is -H, and R9 is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridazinyl group, p is 0, m is 1, R, is -CH3, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R4 is -H, R9is -H, and R9» is -CI. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridazinyl group, p is 0, m is 1, - is -halo, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R4 is -H, R8 is -H, and R9 is -Br. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration, hi another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridazinyl group, p is 0, m is 1, R, is -CI, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, 1is -H, Rs is -H, and is -Br. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridazinyl group, p is 0, m is 1, Rt is -CH3, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R4 is -H, R8 is -H, and R*, is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a thiazanyl group, p is 0, m is 1, - is -CH3 or -halo, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to i the benzothiazolyl group, R4 is -H, R8 is -H, and R9, is -halo. In another embodiment, the

arbon atom to which the R3 group is attached has the R configuration. In another mbodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a thiazanyl group, p is 0, m is 1, Rt is -CH3, x is , R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the enzothiazolyl group, R4 is -H, R8 is -H, and R9» is -CI. In another embodiment, the carbon itom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a thiazanyl group, p is 0, m is 1, R, is -halo, x is }, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the aenzothiazolyl group, R4 is -H, R8 is -H, and R9 is -Br. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AiY is a thiazanyl group, p is 0, m is 1, - is -CI, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R4 is -H, R8 is -H, and Rs is -Br. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a thiazanyl group, p is 0, m is 1, R{ is -CH3, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzothiazolyl group, R4 is -H, R8 is -H, and R9 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, m is 1 and R3 is -(Q-C^alkyl and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- when x is 1 or the benzothiazolyl group when x is 0. In another embodiment, m is 1 and R3 is -(CrC4)alkyl and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- when x is 1 or the benzothiazolyl group when x is 0 and the carbon to which the R3 group is attached is in the R configuration.
In another embodiment, m is 1 and R3 is »CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- when x is 1 or the benzothiazolyl group when x is 0. In another embodiment, m is 1 and R3 is -CH3 and is attached to the

bon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- when x is 1 or the azothiazolyl group when x is 0 and the carbon to which the R3 group is attached is in the R afiguration.
In another embodiment, m is 1 and R3 is -(C1-C4)alkyl and is attached to the rbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- when x is 1 or the nzothiazolyl group when x is 0. In another embodiment, m is 1 and R3 is -(C1-C4)alkyl and attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4 when x is or the benzothiazolyl group when x is 0 and the carbon to which the R3 group is attached is the S configuration.
In another embodiment, m is 1 and R3 is -CH3 and is attached to the carbon ;om adjacent to the nitR9gen attached to the -C(0)-N(R4)- when x is 1 or the benzothiazolyl R9up when x is 0. In another embodiment, m is 1 and R3 is -CH3 and is attached to the arbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- when x is 1 or the enzothiazolyl group when x is 0 and the carbon to which the R3 group is attached is in the S onfiguration.
In another embodiment, m is 1 and R3 is -(C1-C4)alkyl and is attached to the arbon atom adjacent to the nitR9gen attached to the pyrazinyl group, pyridazinyl group, or a hiazanyl group. In another embodiment, m is 1 and R3 is -(C1-C4)alkyl and is attached to the carbon atom adjacent to the nitR9gen attached to the pyrazinyl group, pyridazinyl group, or a hiazanyl group and the carbon to which the R3 group is attached is in the R configuration.. In another embodiment, m is 1 and R3 is -CH3 and is attached to the carbon itom adjacent to the nitR9gen attached to the pyrazinyl group, pyridazinyl group, or thiazanyl group. In another embodiment, m is 1 and R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the pyrazinyl group, pyridazinyl group, or thiazanyl group and the carbon to which the R3 group is attached is in the R configuration.
In another embodiment, m is 1 and R3 is -(C1-C4)alkyl and is attached to the carbon atom adjacent to the nitR9gen attached to the pyrazinyl group, pyridazinyl group, or thiazanyl group. In another embodiment, m is 1 and R3 is -(C1-C4)alkyl and is attached to the carbon atom adjacent to the nitR9gen attached to the pyrazinyl group, pyridazinyl group, or thiazanyl group and the carbon to which the R3 group is attached is in the S configuration.

In another embodiment, m is 1 and R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the pyrazinyl group, pyridazinyl group, or thiazanyl group. In another embodiment, m is 1 and R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the pyrazinyl group, pyridazinyl group, or thiazanyl group and the carbon to which the R3 group is attached is in the S configuration.
The present invention also encompasses compounds of formula (Iia):

and pharmaceutically acceptable salts thereof, where Arls R3, R8, R9, R10 and m, are defined above for the Benzoazolylpiperazine Compounds of formula (Ha).
In one embodiment, AR1 is apyridyl group.
In another embodiment, Ar1 is a pyrimidinyl group.
In another embodiment, Axx is a pyrazinyl group.
In another embodiment, n or p is 0.
In another embodiment, n or p is 1.
In another embodiment, m is 0.
In another embodiment, m is L
In another embodiment, R10 is -H.
In another embodiment, R10 is -(C,-C4)alkyl.
In another embodiment, R10 is -CH3.
In another embodiment, R, is -CI.

In another embodiment, R1 is -Br.
In another embodiment, R, is -I.
In another embodiment, R1 is -(C1-C6)alkyl.
In another embodiment, Rt is -CH3.
In another embodiment, R1 is -N02.
In another embodiment, R1 is -CN.
In another embodiment, - is -OH.
In another embodiment, - is -OCH3.
In another embodiment, - is -NH2.
In another embodiment, R, is -C(halo)3.
In another embodiment, - is ~CH(halo)2.
In another embodiment, - is -CH2(halo).
In another embodiment, n and p are 1 and R2 is -halo, -CN, -OH, -0(Cr C6)alkyl, -N02, or -NH2.
In another embodiment, n and p are 1 and R2 is -(Cl-C10)alkyl, -(C2-C10)alkenyl, -(C2-C10)alkynyL -(C3-C10)cycloalkyl, -(C8-C14)bicycloalkyl, -(C8-C14)tricycloalkyl, -(C5-C10)cycloalkenyl,-(C8-C14)bicycloalkenyl, -(C8-C14)tricycloalkenyl, -(3-to 7-membered)heteR9cycle, or -(7- to 10-membered)bicycloheteR9cycle, each of which is unsubstituted or substituted with one or more R5 groups.
In another embodiment, n and p are 1 and R2 is -phenyl, -naphthyl, -(C14)aryl, or -(5- to 10-membered)heteR9aryl, each of which is unsubstituted or substituted with one or more Rs groups;
In another embodiment, m is 1 and R3 is -halo, -CN, -OH, -0(C1-C6)alkyl, -N02, or -NH2.
In another embodiment, m is 1 and R3 is -C1-C10alkyl, -(C2-C10)alkenyl, -(C2-Cio)alkynyl, -C1-C10cycloalkyl, -(C8-C14)bicycloalkyl, -(C8-C14)tricycloalkyl, -(C5-C10)cycloalkenyl,-(C8-C14)bicycloalkenyl, -(C8-C14)tricycloalkenyl, -(3- to 7-membered)heteR9cycle, or -(7- to 10-membered)bicycloheteR9cycle, each of which is unsubstituted or substituted with one or more R5 groups.

In another embodiment, m is 1 and R3 is -phenyl, -naphthyl, -(CI4)aryl or -(5-to 10-membered)heteR9aryl, each of which is unsubstituted or substituted with one or more R6 groups.
In another embodiment, R9and R9 are each independently -H, halo, -(Cr C6)alkyl, -0(C1-C6)alkyl, -C(halo)3, -CH(halo)2, or -CH2(halo).
In another embodiment, at least one of R8 or R9 is -H.
In another embodiment, n, p, and m are 0; R1 is -CI, -Br, or -I; R4 is -H; and R8 and R9are -H.
In another embodiment, n, p, and m are 0; R, is -CI. R4 is -H; and R8 and R9 are -H.
In another embodiment, n, p, and m are 0; R1 is -Cl( -Br, or -I; R4 is -H; R8 is -halo H; and R9is -H. In another embodiment, R9 is -CI. In another embodiment, R9 is -Br. In another embodiment, R9is -F.
In another embodiment, n, p, and m are 0; R} is -CI; R4 is -H; R8 is -halo; and R9is -H. In another embodiment, R9is -CI. In another embodiment, R9is -Br. In another embodiment, R9is -F.
In another embodiment, n, p, and m are 0; - is -Cl^ -Br, or -I; R4 is -H; R8 is -H; and R9is -CH3. In another embodiment, R9is -CI. In another embodiment, R9is -Br. In another embodiment, R9is -F.
In another embodiment, n, p, and m are 0; R, is -CL R4 is -H; R8 is -H; and R9is -CH3. In another embodiment, R9is -CI. In another embodiment, R9is -Br. In another embodiment, R9is -F.
In another embodiment, n, p, and m are 0; - is -CI -Br, or -I; R4 is -H; R8 is -CH3; and R9is -H. In another embodiment, R9is -CI. In another embodiment, R9is -Br. In another embodiment, R9is -F.
In another embodiment, n, p, and m are 0; - is -CI. R4 is -H; R8 is -CH3; and R9is -H. In another embodiment, R9is -CL In another embodiment, R9is -Br. In another embodiment, R9is -F.
In another embodiment, n, p, and m are 0; R1 is -CI, -Br, or -I; R4 is -H; R8 is -H; and R9is -CF3. In another embodiment, R9is -CL In another embodiment, R9is -Br. In another embodiment, R9is -F.

In another embodiment, n, p, and m are 0; R1 is -CI; R4 is -H; R8 is -H; and R9-CF3. In another embodiment, R9is-CL In another embodiment, R9is -Br. In another nbodiment, R9is -F.
In another embodiment, n, p, and m are 0; R1 is -CI, -Br, or -I; R4 is -H; R8 is IF3; and R9is -H. In another embodiment, R9is -CI. In another embodiment, R9is -Br. In lother embodiment, R9is -F.
In another embodiment, n, p, and m are 0; R1 is -CI; R4 is -H; R9is -CF3; and -9 is -H. In another embodiment, R9is -CL In another embodiment, R9is -Br. In another mbodiment, *R? is -F.
In another embodiment, n, p, and m are 0; R1 is -CI, -Br, or -I; R4 is -H; R8 is H; and R9 is -OCH2CH3. In another embodiment, R9is -CL In another embodiment, R9is -Jr. In another embodiment, R9is -F.
In another embodiment, n, p, and m are 0; R1 is -CI; R4 is -H; R8 is -H; and R9s -OCH2CH3. In another embodiment, R9is -CL In another embodiment, R9is -Br. In mother embodiment, R9is -F.
In another embodiment, n, p, and m are 0; R1 is -CI, -Br, or -I; R4 is -H; R8 is OCH2CH3; and R9is -H. In another embodiment, R9is -CL In another embodiment, R9is -3r. In another embodiment, R9is -F.
In another embodiment, n, p, and m are 0; - is -CI; R4 is -H; R8 is -OCH2CH3; mdRgis-H. In another embodiment, R9is-CL In another embodiment, R9is-Br. In another embodiment, R9is -F.
In another embodiment, n, p, and m are 0; - is -CI, Br, or -I; R4 is -H; R8 is -H; and R9is -CH3.
In another embodiment, n, p, and m are 0; - is -CI; R4 is -H; R8 is -H; and R9is -CH3.
In another embodiment, n, p, and m are 0; Kx is -CI, Br, or -I; R4 is -H; R8 is -CH3; and R9is -H.
In another embodiment, n, p, and m are 0; - is -CI; R4 is -H; R8 is -CH3; and R9is -H.
In another embodiment, n, p, and m are 0; - is -CI, Br, or -I; R4 is -H; R8 is -H;andRgis-CF3.

In another embodiment, n, p, and m are 0; Kx is -CI; R4 is -H; R8 is -H; and R9 3 -CF3.
In another embodiment, n, p, and m are 0; Ra is -CI, Br, or -I; R4 is -H; R8 is CF3; and R, is -H.
In another embodiment, n, p, and m are 0; - is -CI; R4 is -H; R8 is -CF3; and is -H.
In another embodiment, n, p, and m are 0; R2 is -CI, Br, or -I; R4 is -H; R8 is H;andR9is-OCH2CH3.
In another embodiment, n, p, and m are 0; Rt is -CI; R* is -H; R8 is -H; and R9 s -OCH2CH3.
In another embodiment, n, p, and m are 0; Ra is -CI, Br, or -I; R4 is -H; R8 is -OCH2CH3; and R, is -H.
In another embodiment, n, p, and m are 0; Kx is -CI; R4 is -H; R8 is -OCH2CH3; and R9 is -H.
Li another embodiment, n, p, and m are 0, Kx is -CH3, R4 is -H, and R8 and R9 are-BL
In another embodiment, n, p, and m are 0; - is -CH3; R4 is -H; R8 is -H; and R9 is-halo. In another embodiment, R9 is -CI. In another embodiment, R9 is-Br. In another embodiment, R9 is -F.
hi another embodiment, n, p, and m are 0; R, is -CH3; R4 is -H; R8 is -halo; and R9, is -H. In another embodiment, R8 is -CI. In another embodiment, R8 is -Br. In another embodiment, R8 is -F.
hi another embodiment, n, p, and m are 0; Rt is -CH3; R4 is -H; R8 is -H; and R9 is -CH3.
In another embodiment, n, p, and m are 0; Kx is -CH3; R4 is -H; R8 is -CH3; and R9 is -H.
In another embodiment, n, p, and m are 0; R1 is -CH3; R4 is -H; R8 is -H; and R, is -CF3.
In another embodiment, n, p, and m are 0; R1 is -CH3; R4 is -H; R8 is -CF3; and R? is -H.

In another embodiment, n, p, and m are 0; R, is -CH3; R4 is -H; Rs is -H; and is -OCH2CH3.
In another embodiment, n, p, and m are 0; Rl is -CH3; R4 is -H; R8 is CH2CH3; and R9 is -H.
In another embodiment, n, p, and m are 0; R1 is -CF3; R4 is -H; and Rs and 1^
3-H.
In another embodiment, n, p, and m are 0; R1 is -CF3; R4 is -H; R8 is -H; and , is-halo. In another embodiment, R9 is -CI. In another embodiment, R9 is -Br. In another abodiment, R? is -F.
In another embodiment, n, p, and m are 0; - is -CF3; R4 is -H; R8 is -halo; and 9 is -H. In another embodiment, R8 is -CL In another embodiment, R8 is -Br. In another nbodiment, R8 is -F.
In another embodiment, n, p, and m are 0; R1 is -CF3; R4 is -H; R8 is -H; and 9 is -CH3.
In another embodiment, n, p, and m are 0; R, is -CF3; R4 is -H; R8 is -CH3; and ■9 is -H.
In another embodiment, n, p, and m are 0; - is -CF3; R4 is -H; R8 is -H; and [g is -CF3.
In another embodiment, n, p, and m are 0; R, is -CF3; R4 is -H; R8 is -CF3; and is -H.
In another embodiment, n, p, and m are 0; R1 is -CF3; R4 is -H; R8 is -H; and is -OCH2CH3.
In another embodiment, n, p, and m are 0; is -CF3; R4 is -H; R8 is OCH2CH3; and R, is -H.
In another embodiment, n, p, and m are 0; R1 is -CI, -Br, or -I; R9 is -H; R8 is ■ter/-butyl; and R9is -H.
In another embodiment, n, p, and m are 0; - is -CI; R4 is -H; Rs is -tert-butyl; and R9 is -H.
In another embodiment, n, p, and m are 0; - is -CI, -Br, or -I; R4 is -H; R8 is -H; and R9 is -ter*-butyl.

In another embodiment, n, p, and m are 0; - is -CI; R4 is -H; R8 is -H; and R9
\ -tert-butyl.
In another embodiment, n, p, and m are 0; Rt is -CH3; R4 is -H; R8 is -tert-
utyl; and R9 is -H.
In another embodiment, n, p, and m are 0; R2 is -CH3; R4 is -H; R9is -H; and L$ is -tert-butyl.
In another embodiment, n, p, and m are 0; - is -CH3; R4 is -H; R9is -CH3; and is -CH3.
In another embodiment, n is 0, Ar, is -2-(3-chloR9pyridyl)-, m is 1, R3 is -CH3 nd is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazole pR9up, the carbon atom to which the R3 group is attached has the R configuration, R10 is -H, l8 is methyl, and R9 is wo-pR9pyl.
In another embodiment, n is 0, A- is -2-(3-chloR9pyridyl)-, m is 1, R3 is -CH3 md is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazole jR9up, the carbon atom to which the R3 group is attached has the R configuration, R10 is -H, i8 is zso-pR9pyl, and is methyl.
hi another embodiment, n and p are 0; m is 1; R1 is -CI, -Br, or -I; R4 is -H; R3 s -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the Denzoimidazole group; and R8 and are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; - is -CI; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazole group; and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; R1 is -CI, -Br, or -I; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazole group; Rs is -H; and R9 is -halo. In another embodiment R9 is -CI. In another embodiment, R9 is -Br. In another embodiment, R9, is -F. In another embodiment, the carbon

ttom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; R1 is -CI; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazole group; R8 is -H; and R9is -halo. In another embodiment R9is -CI. In another embodiment, R9is -Br. In another embodiment, R9is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; R1 is -CI, -Br, or -I; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazole group; R8 is -halo; and R9is -H. In another embodiment R8 is -CI. In another embodiment, R8 is -Br. In another embodiment, R8 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; R1 is -CI; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazole group; R9is -halo; and R9is -H. In another embodiment R8 is -CI. In another embodiment, R8 is -Br. In another embodiment, R8 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; R1 is -CI, -Br, or -I; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazole group; R8 is -H; and R9is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; - is -CI; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazole group; R8 is -H; and R? is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, n and p are 0; m is 1; R1 is -CI, -Br, or -I; R4 is -H; R3 -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the snzoimidazole group; R8 is -CH3; and R9 is -H. In another embodiment, the carbon atom to hich the R3 group is attached has the R configuration. In another embodiment, the carbon ;om to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; Kx is -C1,;R4 is -H; R3 is -CH3 ad is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazole R9up; R9is -CH3; and RQ is -H. In another embodiment, the carbon atom to which the R3 R9up is attached has the R configuration. In another embodiment, the carbon atom to which lie R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; - is -CI, -Br, or -I; R4 is -H; R3 s -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the enzoimidazole group; R8 is -H; and R9 is -CF3. In another embodiment, the carbon atom to vhich the R3 group is attached has the R configuration. In another embodiment, the carbon itom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; Rt is -CI; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazole group; R8 is -H; and R9 is -CF3. Li another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; R1 is -CI, -Br, or -I; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazole group; R8 is -CF3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; R, is -CI; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazole group; R8 is -CF3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, n and p are 0; m is 1; - is -CI, -Br, or -I; R4 is -H; R3 s -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -aenzoimidazole group; R8 is -H; and R9is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; R1 is -CI; R9 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -benzoimidazole group; R8 is -H; and R9is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; R1 is -CI, -Br, or -I; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazole group; R9is -OCH2CH3; and R9is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; Kx is -CI; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazole group; R9is -OCH2CH3; and R9is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, - is -CH3, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazole group, and R8 and R9are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, R1 is -CH3, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazole group, R8 is -H, and R9is -halo. In another embodiment R9is -CI. In another embodiment, R9is -Br. In another embodiment, R9is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, n and p are 0, m is 1, - is -CH3, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazole group, R8 is -halo, and R9 is -H. In another embodiment R8 is -CI. In another embodiment, R9is -Br. In another embodiment, R8 is -F, In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, Rt is -CH3, 1^ is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazole group, R9is -H, and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, R{ is -CH3, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazole group, R8 is -CH3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, R1 is -CH3, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazole group, R8 is -H, and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, - is -CH3, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazole group, R8 is -CF3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration.
In another embodiment, n and p are 0, m is 1, - is -CH3 R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazole group, R8 is -H, and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, n and p are 0, m is 1, R, is -CH3, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazole group, R8 is -OCH2CH3, and 1^ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, Rt is -CF3, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazole group, and R8 and are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 i group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, K{ is -CF3, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazole group, R9is -H, and R9 is -halo. In another embodiment, R9 is -CL In another embodiment, Rs is -Br. In another embodiment, R9 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, - is -CF3, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazole group, R8 is -halo, and 1^ is -H. In another embodiment, R8 is -CL In another embodiment, R8 is -Br. In another embodiment, R8 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, R1 is -CF3, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazole group, R8 is -H, and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, R1 is -CF3, is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazole group, R8 is -CH3, and R9 is -H. In another embodiment, the carbon atom to which the R3

group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, R, is -CF3, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazole group, R8 is -H, and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, - is -CF3, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazole group, R8 is -CF3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
hi another embodiment, n and p are 0, m is 1, - is -CF3, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazole group, R8 is -H, and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, Ri is -CF3, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazole group, R9is -OCH2CH3 and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration, hi another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; R1 is -CI, -Br, or -I; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazole group; R4 is -H; R8 is -/erf-butyl; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, R{ is -CI, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazole group, R4 is -H, R8 is -tert-butyl, and R9 is -H. In another embodiment, the carbon atom to which the R3

group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; R1 is -CI, -Br, or -I; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazole group; R4 is -H; R8 is -H; and R9 is -tert-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, - is -CI, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazole group, R4 is -H, R8 is -H, and R9 is -tert-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, R1 is -CH3, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazole group, R4 is -H, R8 is -tert-butyl, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, - is -CH3, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazole group, R4 is -H, R8 is -H, and R9 is -tert-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, R1 is -CH3, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazole group, R4 is -H, R9is -CH3, and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group; n is 0; m is 1; R, is -CH3, -CI, -Br, or -I; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group; R4 is -H; R8 is -H; and R9 is -halo. In another embodiment, the

carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group n is 0, m is 1, R, is -CH3, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, R4 is -H, R8 is -H, and R9 is -CI. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group; n is 0; m is 1; R, is -CI, -Br, or -I; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group; R4 is -H; R8 is -H; and R9, is -Br. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0, m is 1, R, is -CI, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, R4 is -H, R8 is -H, and R9, is -Br. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0, m is 1, R, is -CH3, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, R4 is -H, R8 is -H, and R9 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyrimidinyl group; p is 0; m is 1; R, is -CH3, -CI, -Br, or -I; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzimidazolyl group; R4 is -H; R8 is -H; and R9 is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyrimidinyl group, p is 0, m is 1, R, is -CH3, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzimidazolyl group, R4 is -H, R8 is -H, and R9 is -CI. In another embodiment, the carbon

itom to which the R3 group is attached has the R configuration. In another embodiment, the ;arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, A^ is a pyrimidinyl group; p is 0; m is 1; K} is -CI, -Br, or -I; R3 is ~CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzimidazolyl group; R4 is -H; R8 is -H; and B^ is -Br. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyrimidinyl group, p is 0, m is 1, R1 is -CI, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzimidazolyl group, R4 is -H, R8 is -H, and R9 is -Br. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar2 is a pyrimidinyl group, p is 0, m is 1, R, is -CH3, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzimidazolyl group, R4 is -H, R8 is -H, and R9 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrazinyl group; p is 0; m is 1; R1 is -CH3, -CI, -Br, or -I; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzimidazolyl group; R4 is -H; R8 is -H; and R9 is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. Li another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, A^ is a pyrazinyl group, p is 0, m is 1, R, is -CH3, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzimidazolyl group, R4 is -H, R8 is -H, and 1^ is -CI. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, A^ is a pyrazinyl group; p is 0; m is 1; - is -CI, -Br, or -I; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzimidazolyl group; R4 is -H; R8 is -H; and R9 is -Br. In another embodiment, the carbon

atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrazinyl group, p is 0, m is 1, R1 is -CI, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzimidazolyl group, R4 is -H, R8 is -H, and R9 is -Br. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Art is a pyrazinyl group, p is 0, m is 1, R1 is -CH3, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzimidazolyl group, R4 is -H, Rs is -H, and R9 is ~F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, m is 1 and R3 is -(C1-C4)alkyl and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group. In another embodiment, m is 1 and R3 is -(C1-C4)allcyl and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group and the carbon to which the R3 group is attached is in the R configuration.
In another embodiment, m is 1 and R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group. In another embodiment, m is 1 and R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group and the carbon to which the R3 group is attached is in the R configuration.
In another embodiment, m is 1 and R3 is -(C^C^alkyl and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group. In another embodiment, m is 1 and R3 is -(Cj-C4)alkyl and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group and the carbon to which the R3 group is attached is in the S configuration.
In another embodiment, m is 1 and R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group. In another embodiment, m is 1 and R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to

the -C(0)-N(R4)- or the benzothiazolyl group and the carbon to which the R3 group is attached is in the S configuration.
In another embodiment, m is 1 and R3 is -(C1-C4)alkyl and is attached to the carbon atom adjacent to the nitR9gen attached to the pyridyl group, pyrimidinyl group, or pyrazinyl group. In another embodiment, m is 1 and R3 is -(Cj-C4)alkyl and is attached to the carbon atom adjacent to the nitR9gen attached to the pyridyl group, pyrimidinyl group, or pyrazinyl group and the carbon to which the R3 group is attached is in the R configuration.
In another embodiment, m is 1 and R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the pyridyl group, pyrimidinyl group, or pyrazinyl group. In another embodiment, m is 1 and R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the pyridyl group, pyrimidinyl group, or pyrazinyl group and the carbon to which the R3 group is attached is in the R configuration.
In another embodiment, m is 1 and R3 is -(C1-C4)alkyl and is attached to the carbon atom adjacent to the nitR9gen attached to the pyridyl group, pyrimidinyl group, or pyrazinyl group. In another embodiment, m is 1 and R3 is -(C,-C4)alkyl and is attached to the carbon atom adjacent to the nitR9gen attached to the pyridyl group, pyrimidinyl group, or pyrazinyl group and the carbon to which the R3 group is attached is in the S configuration.
In another embodiment, m is 1 and R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the pyridyl group, pyrimidinyl group, or pyrazinyl group. In another embodiment, m is 1 and R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the pyridyl group, pyrimidinyl group, or pyrazinyl group and the carbon to which the R3 group is attached is in the S configuration.
4.4 The Compounds of Formula (lib)
The present invention also encompasses compounds of formula (lib):


rid pharmaceutical^ acceptable salts thereof, where Ar1? R3, R8, R9, A, x, and m, are defined bove for the Benzoazolylpiperazine Compounds of formula (lib).
In one embodiment, Axx is a pyridazinyl group.
In another embodiment, Ar1 is a thiazanyl group.
In another embodiment, x is 1 and A is -C(0)-N(R4)-.
In another embodiment, x is 1 and A is -C(S)-N(R4)-.
In another embodiment x is 0.
In another embodiment, x is 1.
In another embodiment p is 0.
In another embodiment, p is 1.
In another embodiment m is 0.
In another embodiment, m is 1.
In another embodiment, R4 is -H.
In another embodiment, R4 is -(C^C^alkyl.
In another embodiment, R10 is -H.
In another embodiment, R10 is -(C1-C4)alkyl.
In another embodiment, R10 is -CH3.
In another embodiment, A^ is apyrazinyl group, x is 1, and A is -C(0)N(R4)-.
In another embodiment, A^ is apyrazinyl group, x is 1, and A is -C(S)N(R4)-.
In another embodiment, Ar, is a thiazanyl group, x is 1, and A is -C(0)N(R4)-.

In another embodiment, Ai} is a thiazanyl group, x is 1, and A is -C(S)N(R4)~.
In another embodiment, R1 is -H.
In another embodiment, R1 is -CI.
In another embodiment, R, is -Br.
In another embodiment, R1 is -L
In another embodiment, R1 is -F.
In another embodiment Ri is -(C1-C6)alkyL
In another embodiment, R1 is -CH3.
In another embodiment, R1 is -N02.
In another embodiment, Rt is -CN.
In another embodiment, R1 is -OH.
In another embodiment, - is -OCH3.
In another embodiment, R1 is -NH2.
In another embodiment, - is -C(halo)3.
In another embodiment, R, is -CH(halo)2.
In another embodiment, - is -CH2(halo).
In another embodiment, p is 1 and R2 is -halo, -CN, -OH, -0(C,-C6)alkyl, -N02, or -NH2.
In another embodiment, p is 1 and R2 is -(CrCI0)alkyl, -(C2-C10)alkenyl, -(C2-C10)alkynyl, -(C3-C10)cycloalkyl, -(C8-Cl4)bicycloalkyl, -(C8-CM)tricycloalkyl, -(C5-C10)cycloalkenyl,-(C8-C14)bicycloalkenyl, -(C8-C14)tricycloalkenyl, -(3- to 7-membered)heteR9cycle, or -(7- to 10-membered)bicycloheteR9cycle, each of which is imsubstituted or substituted with one or more R9 groups.
In another embodiment, p is 1 and R2 is -phenyl, -naphthyl, -(C14)aryl, or -(5-to 10-membered)heteR9aryl, each of which is imsubstituted or substituted with one or more R6 groups;
In another embodiment, m is 1 and R3 is -halo, -CN, -OH, -O^-C^alkyl, -N02, or -NH2.
In another embodiment, m is 1 and R3 is -C1-C10alkyl, -(C2-C10)alkenyl, -(C2-C10)alkynyl, -(C3-Cl0)cycloalkyl, -(C8-C14)bicycloalkyl, -(C8-C14)tricycloalkyl, -(C5-C10)cycloalkenyl,-(C8-C14)bicycloalkenyl, -(C8-C14)tricycloalkenyl, -(3- to 7-

nembered)heteR9cycle, or -(7- to 10-membered)bicycloheteR9cycle, each of which is insubstituted or substituted with one or more R5 groups.
In another embodiment, m is 1 and R3 is -phenyl, -naphthyl, -(Cj4)aryl or -(5-LO 10-membered)heteR9aiyl, each of which is unsubstituted or substituted with one or more R9groups.
In another embodiment, R8 and R? are each independently -H, halo, -(Cr C6)alkyl, -0(C,-C6)alkyl, -C(halo)3, -CH(halo)2, or -CH2(halo).
In another embodiment, at least one of R8 or R9 is -H.
In another embodiment, p and m are 0, R, is -halo, x is 1, A is -C(0)-N(R4)-, R4 is -H, and R9and R9 are -H.
In another embodiment, p and m are 0, - is -CI, x is 1, A is -C(0)-N(R4)-, R4 is -H, and R8 and R9 are -H.
In another embodiment, p and m are 0, - is -halo, x is 1, A is -C(0)-N(R4)-, R4 is -H, R9is -H, and R9 is -halo. In another embodiment, R9 is -CI. In another embodiment, R9 is -Br. In another embodiment, R9 is -F.
In another embodiment, p and m are 0, R1 is -CI, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -H, and R9 is -halo. In another embodiment, R9 is -CL In another embodiment, R9 is -Br. In another embodiment, 1^ is -F.
In another embodiment, p and m are 0, R1 is -halo, x is 1, A is -C(0)-N(R4)-, R4 is -H, Rs is -halo, and R9 is -H. In another embodiment, R8 is -CL In another embodiment, R8 is -Br. In another embodiment, R8 is -F.
In another embodiment, p and m are 0, R1 is -CI, x is 1, A is -C(0)-N(R4)-, R4 is -H, Rs is -halo, and R9 is -H. In another embodiment, R8 is -CL In another embodiment, R8 is -Br. In another embodiment, R8 is -F.
In another embodiment, p and m are 0, - is -halo, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -H, and R9, is -CH3.
In another embodiment, p and m are 0, - is -CI, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -H, and 1^ is -CH3.
In another embodiment, p and m are 0, - is -halo, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -CH3, and R9 is -EL

In another embodiment, p and m are 0, R1 is -CI, x is 1, A is -C(0)-N(R4)-, R4 -H, R8 is -CH3, and R9, is -H.
In another embodiment, p and m are 0, R1 is -halo, x is 1, A is -C(0)-N(R4)-, 4 is -H, R8 is -H, and R9 is -CF3.
In another embodiment, p and m are 0, R, is -CI, x is 1, A is -C(0)-N(R4)-, R4 -H, R8 is -H, and R9 is -CF3.
In another embodiment, p and m are 0, R, is -halo, x is 1, A is -C(0)-N(R4)-, L4 is -H, R8 is -CF3, and R9 is -H.
hi another embodiment, p and m are 0, R1 is -CI, x is 1, A is -C(0)-N(R4)-, R4 s -H, R8 is -CF3, and R9 is -H.
In another embodiment, p and m are 0, R1 is -halo, x is 1, A is -C(0)-N(R4)-, l4 is -H, R8 is -H, and R9 is -OCH2CH3.
In another embodiment, p and m are 0, R1 is -CI, x is 1, A is -C(0)-N(R4)-, R4 s -H, R8 is -H, and R9 is -OCH2CH3.
In another embodiment, p and m are 0, R1 is -halo, x is 1, A is -C(0)-N(R4)-, El4 is -H, Rs is -OCH2CH3, and R9 is -H.
In another embodiment, p and m are 0, R1 is -CI, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -OCH2CH3, and R9 is -H.
In another embodiment, p and m are 0, R1 is -CH3, x is 1, A is -C(0)-N(R4)-, R4 is -H, and R8 and R9 are -H.
In another embodiment, p and m are 0, R1 is -CH3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -H, and R9 is -halo. In another embodiment, R9 is -CI. hi another embodiment, R9 is -Br. In another embodiment, R9 is -F.
In another embodiment, p and m are 0, R1 is -CH3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -halo, and 1^ is -H. In another embodiment, Rs is -CI. In another embodiment, R8 is -Br. In another embodiment, R8 is -F.
In another embodiment, p and m are 0, R1 is -CH3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R9is -H, and 1^ is -CH3.
In another embodiment, p and m are 0, R1 is -CH3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R9is -CH3, and R9 is -H.

In another embodiment, p and m are 0, R1 is -CH3, x is 1, A is -C(0)-N(R4, l4 is -H, R8 is -H, and R9 is -CF3.
hi another embodiment, p and m are 0, R1 is -CH3, x is 1, A is -C(0)-N(R4)-, El4 is -H, R8 is -CF3, and R9 is -H.
In another embodiment, p and m are 0, R1 is -CH3, x is 1, A is -In another embodiment, p and m are 0, R1 is -CH3 x is 1, A is -C(0)-N(R4)-, R4 is -H, R9is -OCH2CH3, and R, is -H.
In another embodiment, p and m are 0, R1 is -CF3, x is 1, A is -C(0)-N(R4)-, R4 is -H, and R8 and R9 are -H.
In another embodiment, p and m are 0, R1 is -CF3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -H, and R9 is -halo. In another embodiment, R9 is -CL In another embodiment, R9 is -Br. In another embodiment, R9 is -F.
In another embodiment, p and m are 0, Ri is -CF3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -halo, and R9 is -H. hi another embodiment, R8 is -CI. In another embodiment, R8 is -Br. In another embodiment, R8 is -F.
In another embodiment, p and m are 0, R1 is -CF3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -H, and R9 is -CH3.
In another embodiment, p and m are 0, R1 is -CF3, x is 1, A is -C(0)-N(R4)-, RA is -H, R8 is -CH3? and R9 is -H.
In another embodiment, p and m are 0, - is -CF3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -H, and R9 is -CF3.
In another embodiment, p and m are 0, R1 is -CF3, x is 1, A is -C(0)-N(R4)-5 R4 is -H, R8 is -CF3, and R9 is -H.
In another embodiment, p and m are 0, R1 is -CF3, x is 1, A is -C(0)-N(R4)-3 R4 is -H, R8 is -H, and R*, is -OCH2CH3.
In another embodiment, p and m are 0, R1 is -CF3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -OCH2CH3, and 1^ is -H.
In another embodiment, p and m are 0, R} is -halo, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -tert-butyl, and R9 is -H.

In another embodiment, p and m are 0, R1 is -CI, x is 1, A is -C(0)-N(R4)-, R4 s -H, R8 is -tert-butyl, and R9 is -H.
In another embodiment, p and m are 0, - is -halo, x is 1, A is -C(0)-N(R4)-, l4 is -H, R8 is -H, and R9 is -tert-butyl.
In another embodiment, p and m are 0, - is -CI, x is 1, A is -C(0)-N(R4)-, R4 s -H, R9is -H, and R9n is -tert-butyl.
In another embodiment, p and m are 0, R, is -CH3, x is 1, A is -C(0)-N(R4)-, i4 is -H, R8 is -tert-butyl, and R9 is -H.
In another embodiment, p and m are 0, Rt is -CH3, x is 1, A is -C(0)-N(R4)-5 R.4 is -H, R8 is -H, and R9is -tert-butyl.
In another embodiment, p and m are 0, R, is -CH3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -CH3, and R9 is -CH3.
In another embodiment, p is 0, m is 1, - is -halo, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, Rt is -CI, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, and R8 and Rn are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -halo, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -H, and R9 is -halo. In another embodiment, R9 is -Cl. In another embodiment, R9 is -Br. In another embodiment, R9, is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -Cl, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the

-C(0)-N(R4)- group, R8 is -H, and R9 is -halo. In another embodiment, R9 is -CL In another embodiment, R9 is -Br. In another embodiment, R9, is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -halo, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -halo, and R9 is -H. In another embodiment, R8 is -CL In another embodiment, R8 is -Br. In another embodiment, R8 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CI, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -halo, and R9 is -H. In another embodiment, R8 is -Cl. In another embodiment, R8 is -Br. In another embodiment, R8 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -halo, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -H, and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -Cl, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R9is -H, and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -halo, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -CH3, and I^ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, p is 0, m is 1, R1 is -CI, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -CH3, and R9, is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -halo, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to fee nitR9gen attached to the -C(0)-N(R4)- group, R9is -H, and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -CI, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -H, and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -halo, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -CF3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, Rt is -CI, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -CF3, andR9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -halo, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -H, and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, p is 0, m is 1, R} is -CI, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -H, and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. Li another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R{ is -halo, x is 1, A is -C(0)-N(R4)-,R9 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -OCH2CH3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CI, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -OCH2CH3, and R9, is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CH3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -CH3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -H, and R9 is -halo. In another embodiment, R9 is -Cl. In another embodiment, R9is -Br. In another embodiment, R9 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -CH3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -halo, and R9 is -H. In another embodiment, R8 is -Cl. In another embodiment, R8 is -Br. In another embodiment, R8 is -F. In another embodiment, the carbon

am to which the R3 group is attached has the R configuration. In another embodiment, the trbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -CH3, x is 1, A is -C(0)-N(R4, R4 -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the U(0)-N(R4)- group, R8 is -H, and R9 is -CH3. In another embodiment, the carbon atom to 'hich the R3 group is attached has the R configuration. In another embodiment, the carbon torn to which the R3 group is attached has the S configuration.
In another embodiment, p is 05 m is 1, R, is -CH3, x is 1, A is -C(0)-N(R4)-, R4 s -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the C(0)-N(R4)- group, R8 is -CH3, and R9 is -H. In another embodiment, the carbon atom to vhich the R3 group is attached has the R configuration. In another embodiment, the carbon itom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CH3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -H, and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CH3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the «C(0)-N(R4)- group, R9is -CF3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, Rt is -CH3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -H, and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CH3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the

H(0)-N(R4)- group, R8 is -OCH2CH3, and R9 is -H. In another embodiment, the carbon atom which the R3 group is attached has the R configuration. In another embodiment, the carbon torn to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, K} is -CF3, x is 1, A is -C(0)-N(R4)-, R4 s -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the C(0)-N(R4)- group, and R8 and R9 are -H. In another embodiment, the carbon atom to which he R3 group is attached has the R configuration. In another embodiment, the carbon atom to vhich the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R9 is -CF3, x is 1, A is -C(0)-N(R4)-, R4 s ~H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the ■C(0)-N(R4)- group, Rs is -H, and R9 is -halo. In another embodiment, R9 is -CL In another embodiment, R9 is -Br. In another embodiment, R9 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, Rt is -CF3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -halo, and R9 is -H. In another embodiment, R8 is -CL In another embodiment, R8 is -Br. In another embodiment, R9is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R{ is -CF3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -H, and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, Rt is -CF3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -CH3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, p is 0, m is 1, - is -CF3, x is 1, A is -C(0)-N(R4, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -H, and R* is -CF3, In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, die carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CF3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)~ group, R8 is -CF3, and - is -H. hi another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CF3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -H, and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CF3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R9is -OCH2CH3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -halo, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(O)-N(R4)- group, R4 is -H, R9is -tert-butyl, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -CI, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(O)-N(R4)- group, R4 is -H, R8 is -tert-butyi, and R9 is -EL In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, p is 0, m is 1, Rt is -halo, x is 1, A is -C(0)-N(R4, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(O)-N(R4 group, R4 is -H, R8 is -H, and R9, is -tert-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R} is -CI, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(O)-N(R4)- group, R4 is -H, R8 is -H, and R9is -ter*-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -CH3, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(O)-N(R4)- group, R4 is -H, R8 is -tert-butyl, and R9is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, Ra is -CH3, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(O)-N(R4)- group, R4 is -H, R8 is -H, and R9is -terf-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CH3, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(O)-N(R4)- group, R4 is -H, R8 is -CH3, and R9is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p and m are 0, R, is -halo, x is 0, R4 is -H, and R9and R9are -H.
In another embodiment, p and m are 0, Ri is -CI, x is 0, R4 is -H, and R8 and R9are -H.

In another embodiment, p and m are 0, R, is -halo, x is 0, R4 is -H, R8 is -H, and R9, is-halo. In another embodiment, R9is-CI. In another embodiment, R9is-Br. In another embodiment, R9is -F,
In another embodiment, p and m are 0, Rt is -CI, x is 0, R4 is -H, R8 is -H, and R9is-halo. In another embodiment, R9is-CI. In another embodiment, R9is-Br. In another embodiment, R9is -F.
In another embodiment, p and m are 0, - is -halo, x is 0, R4 is -H, R8 is -halo, andRgis-H. In another embodiment, R8 is-CL In another embodiment, R8 is -Br. In another embodiment, R8 is -F.
In another embodiment, p and m are 0, R, is «C1» x is 0, R4 is -H, R8 is -halo, and R9is -H. In another embodiment, R8 is -CL In another embodiment, R8 is -Br. In another embodiment, R8 is -F.
In another embodiment, p and m are 0, - is -halo, x is 0, R4 is -H, R8 is -H, and R9is -CH3.
In another embodiment, p and m are 0, - is -CI, x is 0, R4 is -H, R8 is -H, and JKg is -Hi3.
In another embodiment, p and m are 0, R, is -halo, x is 0, R4 is -H, R8 is -CH3, and R9is -H.
In another embodiment, p and m are 0, - is -CI, x is 0, R4 is -H, R8 is -CH3, and R9is -H.
In another embodiment, p and m are 0, R1 is -halo, x is 0, R4 is -H, R8 is -H, and R9is -CF3.
In another embodiment, p and m are 0, Rt is -CI, x is 0, R4 is -H, R8 is -H, and
R9IS -CF3.
In another embodiment, p and m are 0, R1 is -halo, x is 0, R4 is -H, R8 is -CF3, and R9is -H.
In another embodiment, p and m are 0, Ri is -CI, x is 0, R4 is -H, R8 is -CF3, and R9is -H.
In another embodiment, p and m are 0, R1 is -halo, x is 0, R4 is -H, R8 is -H, and R9is -OCH2CH3.

In another embodiment, p and m are 0, R1 is -CI, x is U, K4 is -n, iv8 is -n, ouu
R9is -OCH2CH3.
In another embodiment, p and m are 0, R: is -halo, x is 0, R4 is -H, R8 is
-OCH2CH3, and R9is -H.
In another embodiment, p and m are 0, - is -CI, x is 0, R4 is -H, R8 is
-OCH2CH3, and R9is -H.
In another embodiment, p and m are 0, R{ is -CH3, x is 0, R4 is -H, and R8 and
R9are -H.
In another embodiment, p and m are 0, - is -CH3, x is 0, R4 is -H, R8 is -H, and R9is-halo. In another embodiment, R9is-CI. In another embodiment, R9is-Br. In another embodiment, R9is -F.
In another embodiment, p and m are 0, R1 is -CH3, x is 0, R4 is -H, R8 is -halo, andRgis-H. In another embodiment, R8 is -CI. In another embodiment, R8 is-Br. In another embodiment, R8 is -F.
In another embodiment, p and m are 0, R1 is -CH3, x is 0, R4 is -H, R8 is -H, and R9is -CH3.
In another embodiment, p and m are 0, - is -CH3, x is 0, R4 is -H, Rs is -CH3, and R9is -H.
In another embodiment, p and m are 0, R1 is -CH3, x is 0, R4 is -H, R8 is -H, andRgis-CF3.
In another embodiment, p and m are 0, R, is -CH3, x is 0, R4 is -H, R8 is -CF3, and R9is -H.
In another embodiment, p and m are 0, R1 is -CH3, x is 0, R4 is -H, R8 is -H, and R9is -OCH2CH3.
In another embodiment, p and m are 0, - is -CH3, x is 0, R4 is -H, R8 is -OCH2CH3, and R9is -H.
In another embodiment, p and m are 0, R1 is -CF3, x is 0, R4 is -H, and R8 and R9are -H.
In another embodiment, p and m are 0, - is -CF3, x is 0, R4 is -H, R8 is -H, and R9is-halo. In another embodiment, R9is-CI. In another embodiment, R9is-Br. In another embodiment, R9is -F.

In another embodiment, p and m are 0, R, is -CF3, x is 0, R4 is -H, R9is -halo, idRgis-H. In another embodiment, Rs is -CI. In another embodiment, R8 is-Br. In tiother embodiment, R8 is -F.
In another embodiment, p and m are 0, R1 is -CF3, x is 0, R4 is -H, R8 is -H, nd R9is -CH3.
In another embodiment, p and m are 0, R1 is -CF3, x is 0, R4 is -H, R8 is -CH3, nd R9 is -H.
In another embodiment, p and m are 0, R1 is -CF3, x is 0, R4 is -H, R8 is -H, tnd R9is -CF3.
In another embodiment, p and m are 0, R1 is -CF3, x is 0, R9 is -H, R8 is -CF3, ind R9is -H.
In another embodiment, p and m are 0, R{ is -CF3, x is 0, R4 is -H, R8 is -H, and R9 is -OCH2CH3.
In another embodiment, p and m are 0, R1 is -CF3, x is 0, R4 is -H, R8 is -OCH2CH3, and R9is -H.
In another embodiment, p and m are 0, R1 is -halo, x is 0, R4 is -H, R8 is -tert-butyl, and R9is -H.
In another embodiment, p and m are 0, - is -CI, x is 0, R4 is -H, R8 is -tert-butyl, and R? is -H.
In another embodiment, p and m are 0, - is -halo, x is 0, R4 is -H, R8 is -H, and R9is -terf-butyl.
In another embodiment, p and m are 0, R1 is -CI, x is 0, R9 is -H, R8 is -H, and R9is -te/Y-butyl.
In another embodiment, p and m are 0, - is -CH3, x is 0, R4 is -H, R8 is -iert~ butyl, and R9is -H.
In another embodiment, p and m are 0, R1 is -CH3, x is 0, R4 is -H, R8 is -H, and R9is -tert-butyl.
In another embodiment, p and m are 0, R, is -CH3, x is 0, R4 is -H, R8 is -CH3, and R9is -CH3.
In another embodiment, p is 0, m is 1, R1 is -halo, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl

group, and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CI, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, and R8 and R9 are -EL In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R} is -halo, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, R9is -H, and R9 is -halo. In another embodiment, R9is -CI. In another embodiment, R9 is -Br. In another embodiment, R9 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CI, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, R8 is -H, and R9is -halo. In another embodiment, R9 is -CI. In another embodiment, R9is -Br. In another embodiment, R9is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -halo, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, R8 is -halo, and R9is -H. In another embodiment, R8 is -CI. In another embodiment, R8 is -Br. In another embodiment, R8 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CI, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, R8 is -halo, and R9 is -H. In another embodiment, R8 is -CL In another embodiment, R8 is

-Br. In another embodiment, R8 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -halo, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, R8 is -H, and R9, is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CI, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, R8 is -H, and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -halo, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, R8 is -CH3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CI, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, R8 is -CH3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. La another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -halo, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the mtR9gen attached to the benzoimidazolyl group, R8 is -H, and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -CI, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, R8 is -H, and R? is -CF3. In another embodiment, the carbon atom to which the R3 group is

ttached has the R configuration. In another embodiment, the carbon atom to which the R3 ;R9up is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -halo, x is 0, R4 is -H, R3 is -CH3 nd is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl ;R9up, R8 is -CF3, and R9 is -H. In another embodiment, the carbon atom to which the R3 pR9up is attached has the R configuration. In another embodiment, the carbon atom to which he R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, Rt is -CI, x is 0, R4 is -H, R3 is -CH3 and s attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, lg is *CF3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is ittached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -halo, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, R8 is -H, and R9is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -CI, x is 0, R4 is -H, R3 is -CH3 and LS attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, R8 is -H, and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -halo, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the mtR9gen attached to the benzoimidazolyl group, R9is -OCH2CH3, and is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R2 is -CI, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, R8 is -OCH2CH3, and 1^ is -H. In another embodiment, the carbon atom to which the R3

group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CH3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, and R8 and Rp are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, Rt is -CH3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, R8 is -H, and R9 is -halo. In another embodiment, R9 is -CI. In another embodiment, Rs is -Br. In another embodiment, R9 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CH3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, R8 is -halo, and R9 is -H. In another embodiment, Rs is -CI. In another embodiment, R8 is -Br. In another embodiment, R8 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -CH3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, R8 is -H, and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -CH3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, R8 is -CH3, and Rt» is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CH3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl

group, R8 is -H, and R9is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CH3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, R8 is -CF3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CH3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, R8 is -H, and R9is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
hi another embodiment, p is 0, m is 1, R1 is -CH3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, R8 is -OCH2CH3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CF3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -CF3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, Rs is -H, and R9 is -halo. In another embodiment, R9 is -CI. In another embodiment, R9is -Br. In another embodiment, R9 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CF3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl

group, R8 is -halo, and R9 is -H. In another embodiment, R8 is -CI. In another embodiment, R8 is -Br. In another embodiment, R8 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R} is -CF3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, R8 is -H, and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CF3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, R9is -CH3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CF3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, R8 is -H, and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -CF3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, R8 is -CF3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R{ is -CF3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, R8 is -H, and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, Rt is -CF3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl

group, R8 is -OCH2CH3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -halo, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, R4 is -H, R8 is -fert-butyl, and R9, is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -CI, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, R4 is -H, R8 is -tert-butyl, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -halo, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, R4 is -H, R8 is -H, and R9 is -terf-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CI, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, R4 is -H, R8 is -H, and R9 is -terf-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, K} is -CH3, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, R4 is -H, R8 is -tert-butyl, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -CH3, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, R4 is -H, R9is -H, and R9 is -terf-butyl. In another embodiment, the carbon atom to which the

group is attached has the R configuration. In another embodiment, the carbon atom to ich the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, Rt is -CH3, x is 0, R3 is -CH3 and is ached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, is -H, R8 is -CH3, and R9, is -CH3. In another embodiment, the carbon atom to which the R3 :up is attached has the R configuration. In another embodiment, the carbon atom to which 3 R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridazinyl group, p is 0, m is 1, R1 is -CH3 or alo, x is 1, A is -C(0)-N(R4, R3 is -CH3 and is attached to the carbon atom adjacent to the tR9gen attached to the -C(0)-N(R4)- group, R4 is -H, R8 is -H, and R9 is -halo. In another nbodiment, the carbon atom to which the R3 group is attached has the R configuration. In lother embodiment, the carbon atom to which the R3 group is attached has the S snfiguration.
In another embodiment, Ar1 is a pyridazinyl group, p is 0, m is 1, R, is -CH3, x s 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen ttached to the -C(0)-N(R4)- group, R4 is -H, R8 is -H, and R9 is -Cl. In another embodiment, tie carbon atom to which the R3 group is attached has the R configuration. In another smbodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AiY is a pyridazinyl group, p is 0, m is 1, Rl is -halo, x s 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R4 is -H, R8 is -H, and R9 is -Br, In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ara is a pyridazinyl group, p is 0, m is 1, - is -Cl, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R4 is -H, R8 is -H, and R9 is -Br. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridazinyl group, p is 0, m is 1, R{ is -CH3, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4 group, R4 is -H, R8 is -H, and R9is -F. In another embodiment,

the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a thiazanyl group, p is 0, m is 1, R, is -CH3 or -halo, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R4 is -H, R8 is -H, and Rp is -halo, hi another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a thiazanyl group, p is 0, m is 1, - is -CH3, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R4 is -H, R9is -H, and R9 is -Cl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ax{ is a thiazanyl group, p is 0, m is 1, Rz is -halo, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R4 is -H, R8 is -H, and R9is -Br. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a thiazanyl group, p is 0, m is 1, R, is -Cl, x is 1, A is -C(0)-N(R4)~, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R4 is -H, R8 is -H, and R9 is -Br. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
hi another embodiment, Ar, is a thiazanyl group, p is 0, m is 1, R1 is -CH3, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R4 is -H, R8 is -H, and R9is -F. hi another embodiment, the carbon atom to which the R3 group is attached has the R configuration, hi another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridazinyl group, p is 0, m is 1, Ri is -CH3 or -halo, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, R4 is -H, R8 is -H, and 1^ is -halo. In another embodiment, the

irbon atom to which the R3 group is attached has the R configuration. In another nbodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridazinyl group, p is 0, m is 1, R, is -CH3, x 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the snzoimidazolyl group, R4 is -H, R8 is -H, and R9 is -CI. In another embodiment, the carbon iom to which the R3 group is attached has the R configuration. In another embodiment, the arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridazinyl group, p is 0, m is 1, R, is -halo, x 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the enzoimidazolyl group, R4 is -H, R8 is -H, and R9 is -Br. In another embodiment, the carbon torn to which the R3 group is attached has the R configuration. In another embodiment, the arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridazinyl group, p is 0, m is 1, R, is -CI, x is , R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the enzoimidazolyl group, R4 is -H, R8 is -H, and R9 is -Br. In another embodiment, the carbon itom to which the R3 group is attached has the R configuration. In another embodiment, the ;arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridazinyl group, p is 0, m is 1, R, is -CH3, x s 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the Denzoimidazolyl group, R9 is -H, R8 is -H, and R9 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a thiazanyl group, p is 0, m is 1, R, is -CH3 or -halo, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, R4 is -H, R8 is -H, and R9 is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a thiazanyl group, p is 0, m is 1, R, is -CH3, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, R4 is -H, R8 is -H, and R9 is -CI. In another embodiment, the carbon

;om to which the R3 group is attached has the R configuration. In another embodiment, the irbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a thiazanyl group, p is 0, m is 1, - is -halo, x is , R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the enzoimidazolyl group, R4 is -H, R9is -H, and R1 is -Br. In another embodiment, the carbon torn to which the R3 group is attached has the R configuration. In another embodiment, the arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, R1 is a thiazanyl group, p is 0, m is 1, Rt is -CI, x is ), R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the enzoimidazolyl group, R4 is -H, R8 is -H, and R9 is -Br. In another embodiment, the carbon itom to which the R3 group is attached has the R configuration. In another embodiment, the ;arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a thiazanyl group, p is 0, m is 1, - is -CH3, x is ), R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzoimidazolyl group, R4 is -H, R8 is -H, and is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, m is 1 and R3 is -(C1-C4)alkyl and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- when x is 1 or the benzoimidazolyl group when x is 0. In another embodiment, m is 1 and R3 is -(Cj-C^alkyl and is attached to the carbon atom adjacent to the mtR9gen attached to the -C(0)-N(R4)- when x is 1 or the benzoimidazolyl group when x is 0 and the carbon to which the R3 group is attached is in the R configuration.
In another embodiment, m is 1 and R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- when x is 1 or the benzoimidazolyl group when x is 0. In another embodiment, m is 1 and R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- when x is 1 or the benzoimidazolyl group when x is 0 and the carbon to which the R3 group is attached is in the R configuration.
In another embodiment, m is 1 and R3 is -(C1-C4)alkyl and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- when x is 1 or the

izoimidazolyl group when x is 0. In another embodiment, m is 1 and R3 is -(C1-C4)alkyl I is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- when s 1 or the benzoimidazolyl group when x is 0 and the carbon to which the R3 group is ached is in the S configuration.
In another embodiment, m is 1 and R3 is -CH3 and is attached to the carbon )m adjacent to the nitR9gen attached to the -C(0)-N(R4)- when x is 1 or the nzoimidazolyl group when x is 0. In another embodiment, m is 1 and R3 is -CH3 and is tached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- when x is 1 the benzoimidazolyl group when x is 0 and the carbon to which the R3 group is attached is the S configuration.
In another embodiment, m is 1 and R3 is -(C1-C4)alkyl and is attached to the arbon atom adjacent to the nitR9gen attached to the pyridazinyl group or thiazanyl group. In aother embodiment, m is 1 and R3 is -(C1-C4)alkyl and is attached to the carbon atom ijacent to the nitR9gen attached to the pyridazinyl group or thiazanyl group and the carbon to rtiich the R3 group is attached is in the R configuration.
In another embodiment, m is 1 and R3 is -CH3 and is attached to the carbon torn adjacent to the mtR9gen attached to the pyridazinyl group or thiazanyl group. In another mbodiment, m is 1 and R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen ittached to the pyridazinyl group or thiazanyl group and the carbon to which the R3 group is ittached is in the R configuration.
In another embodiment, m is 1 and R3 is -(C1-C4)alkyl and is attached to the :arbon atom adjacent to the nitR9gen attached to the pyridazinyl group or thiazanyl group. In mother embodiment, m is 1 and R3 is -(CVC4)alkyl and is attached to the carbon atom adjacent to the nitR9gen attached to the pyridazinyl group or thiazanyl group and the carbon to which the R3 group is attached is in the S configuration.
In another embodiment, m is 1 and R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the pyridazinyl group or thiazanyl group. In another embodiment, m is 1 and R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the pyridazinyl group or thiazanyl group and the carbon to which the R3 group is attached is in the S configuration.


ind phannaceutically acceptable salts thereof, where Ar„ R3, R8, R9, A, x, and m, are defined ibove for the Benzoazolylpiperazine Compounds of formula (Ilia).
In one embodiment, Ar1 is a pyridyl group.
In another embodiment, Ar1 is apyrimidinyl group.
In another embodiment, x is 1 and A is -C(0)-N(R4)-.
In another embodiment, x is 1 and A is -C(S)-N(R4)-.
In another embodiment x is 0.
In another embodiment x is 1.
In another embodiment n or p is 0.
In another embodiment n or p is 1.
In another embodiment m is 0.
In another embodiment m is 1.
In another embodiment, Axx is a pyridyl group, x is 1, and A is -C(0)N(R4)-.
In another embodiment, Ar, is a pyridyl group, x is 1, and A is -C(S)N(R4)-.
In another embodiment, Axx is a pyrimidinyl group, x is 1, and A is -C(0)N(R4)-.
In another embodiment, Ar, is a pyrimidinyl group, x is 1, and A is -C(S)N(R4)-.

In another embodiment, - is -CI.
In another embodiment, R1 is -Br.
In another embodiment, R1 is -L
In another embodiment, R, is -(C1-C6)alkyl.
In another embodiment, R1 is -CH3.
In another embodiment, R1 is -N02.
In another embodiment, R1 is -CN.
In another embodiment, R1 is -OH.
In another embodiment, R1 is -OCH3.
In another embodiment, R1 is -NH2.
In another embodiment, R{ is -C(halo)3.
In another embodiment, R, is -CH(halo)2.
In another embodiment, - is -CH2(halo).
In another embodiment, n and p are 1 and R2 is -halo, -CN, -OH, -0(Cr C6)alkyl, -N02, or -NH2.
In another embodiment, n and p are 1 and R2 is -C1-C10alkyl, -(C2-C10)alkenyl, -(C2-C10)alkynyl, -(C3-C10)cycloalkyl, -(C8-C14)bicycloalkyl, -(C8-C14)tricycloalkyl, -(C5-C10)cycloalkenyl,-(C1-C,4)bicycloalkenyl, -(C1-C14)tricycloalkenyl, -(3-to 7-membered)heteR9cycle, or -(7- to 10-membered)bicycloheteR9cycle, each of which is unsubstituted or substituted with one or more R5 groups.
In another embodiment, n and p are 1 and R2 is -phenyl, -naphthyl, -(C14)aryl, or -(5- to 10-membered)heteR9aryl, each of which is unsubstituted or substituted with one or more R6 groups;
In another embodiment, m is 1 and R3 is -halo, -CN, -OH, -0(C,-C6)alkyl, -N02, or -NH2.
hi another embodiment, m is 1 and R3 is -C1-C10alkyl, -(C2-Cl0)alkenyl, -(C2-CI0)alkynyl, -(C3-C,0)cycloalkyl, -(C8-Ci4)bicycloalkyl, -(C8-Ci4)tricycloalkyl, -(C5-C10)cycloalkenyl,-(C8-C14)bicycloalkenyl, -(C8-C14)tricycloalkenyl, -(3- to 7-membered)heteR9cycle, or -(7- to 10-membered)bicycloheteR9cycle, each of which is unsubstituted or substituted with one or more R5 groups.

In another embodiment, m is 1 and R3 is -phenyl, -naphthyl, -(C14)aryl or -(5-to 10-membered)heteR9aryl, each of which is unsubstituted or substituted with one or more R6
groups.
In another embodiment, R4 is -H.
In another embodiment, R4 is -(C1-C6)alkyL
In another embodiment, R8 and R9 are each independently -H, halo, -(Cr C6)alkyl, -0(C1-C6)alkyl, -C(halo)3, -CH(halo)2, or -CH2(halo).
In another embodiment, at least one of R8 or R9 is -H.
In another embodiment, n, p, and m are 0; R, is -CI, -Br, or -I; x is 1; A is -C(0)-N(R4)-; R4 is -H; and R8 and R, are -H.
In another embodiment, n, p, and m are 0; R1 is -CI; x is 1; A is -C(0)-N(R4)-; R4 is -H; and R9and R9 are -H.
In another embodiment, n, p, and m are 0; R, is -CI, -Br, or -I; x is 1; A is -C(0)-N(R4; R4 is -H; R8 is -H; and R9, is -halo. In another embodiment, R9, is -Cl. In another embodiment, R9 is -Br. In another embodiment, R9 is -F.
In another embodiment, n, p, and m are 0; R1 is -Cl; x is 1; A is -C(0)-N(R4)-; R4 is -H; R8 is -H; and R9 is -halo. In another embodiment, R9 is -Cl. In another embodiment, R9 is -Br. In another embodiment, R9 is -F.
In another embodiment, n, p, and m are 0; R1 is -Cl, -Br, or -I; x is 1; A is -C(0)-N(R4)-; R4 is -H; R8 is -halo; and R9 is -H. In another embodiment, R8 is -Cl. In another embodiment, R8 is -Br. In another embodiment, R8 is -F.
In another embodiment, n, p, and m are 0; R1 is -Cl; x is 1; A is -C(0)-N(R4)-; R4 is -H; R8 is -halo; and R9 is -H. In another embodiment, R8 is -Cl. In another embodiment, R8 is -Br. In another embodiment, R8 is -F.
In another embodiment, n, p, and m are 0; R1 is -Cl, -Br, or -I; x is 1; A is -C(0)-N(R4)-; R4 is -H; R8 is -H; and R9 is -CH3.
In another embodiment, n, p, and m are 0; - is -Cl; x is 1; A is -C(0)-N(R4)-; R4 is -H; R8 is -H; and R? is -CH3.
In another embodiment, n, p, and m are 0; R1 is -Cl, -Br, or -I; x is 1; A is -C(0)-N(R4; R4 is -H; R8 is -CH3; and R9 is -H.

In another embodiment, n, p, and m are 0; R1 is -CI; x is 1; A is -C(0)-N(R4)-; R4 is -H; R8 is -CH3; and R9, is -H.
In another embodiment, n, p3 and m are 0; - is -CI, -Br, or -I; x is 1; A is -C(0)-N(R4; R4 is -H, R8 is -H; and R9» is -CF3.
In another embodiment, n, p, and m are 0; R1 is -CI; x is 1; A is -C(0)-N(R4)-; l4 is -H; R8 is -H; and R9, is -CF3.
In another embodiment, n, p, and m are 0; R1 is -CI, -Br, or -I; x is 1; A is -C(0)-N(R4)-; R4 is -H; R8 is -CF3; and R9 is -H.
In another embodiment, n, p, and m are 0; is -CI; x is 1; A is -C(0)-N(R4)s R4 is -H; R8 is -CF3; and R9 is -H.
In another embodiment, n, p, and m are 0; R, is -CI, -Br, or -I; x is 1; A is -C(0)-N(R4)-; R4 is -H; R8 is -H; and R» is -OCH2CH3.
In another embodiment, n, p, and m are 0; R1 is -CI; x is 1; A is -C(0)-N(R4)-; R4 is -H; R8 is -H; and R, is -OCH2CH3.
In another embodiment, n, p, and m are 0; R, is -CI, -Br, or -I; x is 1; A is -C(0)-N(R4)s R4 is -H; R8 is -OCH2CH3; and R, is -H.
In another embodiment, n, p, and m are 0; R1 is -CI; x is 1; A is -C(0)-N(R4)s R4 is -H; R8 is -OCH2CH3; and R9 is -H.
In another embodiment, n, p, and m are 0, - is -CH3, x is 1, A is -C(0)-N(R4)-, R4 is -H, and R8 and R, are -H.
another embodiment, n, p, and m are 0, - is -CH3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -H, and R9, is -halo. In another embodiment, R9 is -Cl. In another embodiment, R, is -Br, In another embodiment, R9 is -F.
In another embodiment, n, p, and m are 0, R1 is -CH3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -halo, and R9 is -H. In another embodiment, Rgis-Cl. In another embodiment, R8 is -Br. In another embodiment, R9is -F.
In another embodiment, n, p, and m are 0, R1 is -CH3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -H, and R9 is -CH3.
In another embodiment, n, p, and m are 0, - is -CH3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -CH3, and R9, is -H.
In another embodiment, n, p, and m are 0, Rt is -CH3, x is 1, A is

-C(0)-N(R4, R4 is -H, R8 is -H, and R, is -CF3.
In another embodiment, n, p, and m are 0, R1 is -CH3, x is 1, A is -C(O)-N(R4)-, R4 is -H, R8 is -CF3, and R, is -H.
In another embodiment, n, p, and m are 0, - is -CH3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -H, and R, is -OCH2CH3.
In another embodiment, n, p, and m are 0, R1 is -CH3, x is 1, A is -C(0)-N(R4, R4 is -H, R9is -OCH2CH3, and R9 is -H.
In another embodiment, n, p, and m are 0, Ri is -CF3, x is 1, A is -C(0)-N(R4)-? R4 is -H, and R8 and R, are -H.
In another embodiment, n, p, and m are 0, - is -CF3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -H, and R, is -halo. In another embodiment, R9 is -Cl. In another embodiment, R9» is -Br. In another embodiment, F^ is -F.
In another embodiment, n, p, and m are 0, R1 is -CF3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R9is -halo, and R, is -H. In another embodiment, R8 is -Cl. In another embodiment, R9is -Br. In another embodiment, R8 is -F.
In another embodiment, n, p, and m are 0, Ri is -CF3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R9is -H, and R, is -CH3.
In another embodiment, n, p, and m are 0, - is -CF3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -CH3, and R, is -H.
In another embodiment, n, p, and m are 0, R1 is -CF3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -H, and R9» is -CF3.
In another embodiment, n, p, and m are 0, R1 is -CF3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -CF3, and R9, is -H.
In another embodiment, n, p, and m are 0, - is -CF3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R9is -H, and R9» is -OCH2CH3.
In another embodiment, n, p, and m are 0, R, is -CF3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -OCH2CH3, and R, is -H.
In another embodiment, n, p, and m are 0; R1 is -Cl, -Br, or -I; x is 1; A is -C(0)-N(R4)-; R4 is -H; R8 is -ter/-butyl; and R9, is -H.
In another embodiment, n, p, and m are 0; - is -Cl; x is 1; A is -C(0)-N(R4)-; R4 is -H; R8 is -^eR9-butyl; and R9 is -H.

In another embodiment, n, p, and m are 0; RY is -CI, -Br, or -I; x is 1; A is ;(0)-N(R4; R4 is -H; R8 is -H; and K is -tert-butyl
In another embodiment, n, p, and m are 0; R1 is -CI; x is 1; A is -C(0)-N(R4; 4 is -H; R8 is -H; and R9 is -tert-butyl.
In another embodiment, n, p, and m are 0; - is -CH3, x is 1, A is -C(O)-f(R4)-? R4 is -H, R8 is -terMnrtyl, and R9 is -H.
In another embodiment, n, p, and m are 0, - is -CH3, x is 1, A is C(0)-N(R4, R4 is -H, R8 is -H, and R9 is -tert-butyl
In another embodiment, n, p, and m are 0, - is -CH3, x is 1, A is C(0)-N(R4)-, R4 is -H, R8 is -CH3, and R, is -CH3.
In another embodiment, n is 0, Ar1 is -2-(3-nitR9pyridyl)-, m is 0, x is 0, and R8 md R? are -H.
In another embodiment, n and p are 0; m is 1; - is -CI, -Br, or -I; x is 1; A is -C(0)-N(R4)s R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group; and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1, - is -CI; x is 1, A is -C(0)-N(R4)-; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group; and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; - is -CI, -Br, or -I; x is 1; A is -C(0)-N(R4)-; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group; R8 is -H; and R9 is -halo, hi another embodiment R9 is -CL In another embodiment, R9 is -Br. In another embodiment, R9 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, n and p are 0; m is 1; R1 is -CI; x is 1; A is -C(O)-N(R4)-; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group; R8 is -H; and R9 is -halo. In another embodiment R9 is -CI. In another embodiment, R, is -Br. In another embodiment, R9, is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; R1 is -CI, -Br, or -I; x is 1; A is -C(0)-N(R4)-; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the mtR9gen attached to the -C(0)-N(R4)- group; R8 is -halo; and R9, is -H. In another embodiment R8 is -CI. In another embodiment, R9is -Br. In another embodiment, R8 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; - is -CI; x is 1; A is -C(O)-N(R4)-; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group; R8 is -halo; and R9 is -H. In another embodiment R8 is -CI. In another embodiment, R8 is -Br. In another embodiment, Rs is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; R1 is -CI, -Br, or -I; x is 1; A is -C(0)-N(R4)-; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group; R8 is -H; and R9is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; - is -CI; x is 1; A is -C(O)-N(R4)-; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group; R8 is -H; and R9is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, n and p are 0; m is 1; R1 is -CI, -Br, or -I; x is 1; A is -C(0)-N(R4)-; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group; R8 is -CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; - is -CI; x is 1; A is -C(O)-N(R4)-; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group; R8 is -CH3; and R9, is -H. hi another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another ' embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; - is -CI, -Br, or -I; x is 1; A is -C(0)-N(R4)-; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group; R8 is -H; and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; Rz is -CI; x is 1; A is -C(O)-N(R4)-; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group; R8 is -H; and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; R2 is -CI, -Br, or -I; x is 1; A is -C(0)-N(R4)-; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group; R8 is -CF3; and K^ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; R, is -CI; x is 1; A is -C(O)-N(R4)-; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C^-N^)- group; R8 is -CF3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; R1 is -CI, -Br, or -I; x is 1; A is

■C(0)-N(R4; R4 is -H; R3 is -CH3 and is attached to the carbon atom aajacent to me mtR9gen attached to the -C(0)-N(R4)- group; R8 is -H; and R9, is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; Ry is -CI; x is 1; A is -C(O)-N(R4)-; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group; R8 is -H; and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; R1 is -CI, -Br, or -I; x is 1; A is -C(0)-N(R4)-; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the mtR9gen attached to the -C(0)-N(R4)- group; R8 is -OCH2CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; R1 is -CI; x is 1; A is -C(O)-N(R4)-; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group; R9is -OCH2CH3; and R9» is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, - is -CH3, x is 1, A is -C(O)-N(R4-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, R, is -CH3, x is 1, A is -C(O)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -H, and R9 is -halo. In another embodiment R9 is -CI. In another embodiment, R9 is -Br. In another embodiment, R9 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, n and p are 0, m is 1, Ri is -CH3, x is 1, A is -C(0)~ Sf(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen ittached to the -C(0)-N(R4)- group, R8 is -halo, and R9 is -H. In another embodiment R8 is •CI. In another embodiment, R8 is -Br. In another embodiment, R8 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, R1 is -CH3, x is 1, A is -C(O)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -H, and R*, is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, - is -CH3, x is 1, A is -C(O)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -CH3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, - is -CH3, x is 1, A is -C(O)-N(R4)-, R9 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4 group, R8 is -H, and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, R1 is -CH3, x is 1, A is -C(O)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -CF3, and R9is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, Rt is -CH3, x is 1, A is -C(O)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen ' attached to the -C(0)-N(R4)- group, R8 is -H, and R9 is -OCH2CH3. In another embodiment,

Le carbon atom to which the R3 group is attached has the R configuration. In another nbodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, - is -CH3, x is 1, A is -C(0)-f(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen ttached to the -C(0)-N(R4)- group, R8 is -OCH2CH3, and R9 is -H. In another embodiment, ae carbon atom to which the R3 group is attached has the R configuration. In another mbodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, Rt is -CF3, x is 1, A is -C(O)-sf(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen ittached to the -C(0)-N(R4)- group, and R8 and R9are -H. In another embodiment, the carbon itom to which the R3 group is attached has the R configuration. In another embodiment, the" :arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, R1 is -CF3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -H, and R9is -halo. In another embodiment R9is -CI. In another embodiment, R9is -Br. In another embodiment, R9is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, Rt is -CF3, x is 1, A is -C(O)-N(R4)~, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -halo, and R9is -H. In another embodiment R8 is -CI. In another embodiment, R8 is -Br. In another embodiment, R8 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, - is -CF3, x is 1, A is -C(O)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -H, and R9is -CH3. In another embodiment, the i carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, n and p are 0, m is 1, R, is -CF3, x is 1, A is -C(O)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is «CH3, and R* is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, R1 is -CF3, x is 1, A is -C(O)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4 group, R8 is -H, and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, R1 is -CF3, x is 1, A is -C(O)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R9is -CF3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, R, is -CF3, x is 1, A is -C(O)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -H, and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, R1 is -CF3, x is 1, A is -C(O)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -OCH2CH3, and R9, is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; R1 is -CI, -Br, or -I; x is 1; A is -C(0)-N(R4)s R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group; R4 is -H; R8 is -terf-butyl; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, n ana p are u; m is i, rs^ is -v^i, A K I,AIS -MV;~ NT(R4)-; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the C(0)-N(R4)- group; R4 is -H; R8 is -terr-butyl; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; R1 is -CI, -Br, or -I; x is 1; A is C(0)-N(R4)-; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached :o the -C(0)-N(R4)- group; R4 is -H; R8 is -H; and R9 is -terf-butyl. In another embodiment, he carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; R} is -CI; x is 1; A is -C(O)-N(R4)-; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group; R4 is -H; R8 is -H; and R9, is -terf-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, - is -CH3, x is 1, A is -C(O)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R4 is -H, R8 is -terf-butyl, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, R1 is -CH3, x is 1, A is -C(O)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R4 is -H, R8 is -H, and R9 is -terf-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. La another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, R1 is -CH3, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R4 is -H, R8 is -CH3, and Rp is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, n, p, and m are 0; R1 is -CI, -Br, or -I; x is 0; R4 is -H; nd R9and R9 are -H.
In another embodiment, n, p, and m are 0; - is -CI; x is 0; R4 is -H; and Rs ind R9 are -H.
In another embodiment, n, p, and m are 0; - is -CI, -Br, or -I; x is 0; R4 is -H; l8 is -H; and 1^ is -halo. In another embodiment, R9 is -CI. In another embodiment, R9 is Br. hi another embodiment, R9 is -F.
Li another embodiment, n, p, and m are 0; Rt is -CI; x is 0; R4 is -H; R8 is -H; and R9 is -halo. In another embodiment, R9 is -CI. In another embodiment, R9 is -Br. In another embodiment, R9 is -F.
hi another embodiment, n, p, and m are 0; Rt is -CI, -Br, or -I; x is 0; R4 is -H; R9is -halo; and R9 is -H. In another embodiment, R8 is -CI. In another embodiment, R8 is -Br. In another embodiment, R8 is -F.
In another embodiment, n, p, and m are 0; R1 is -CI, x is Q; R4 is -H; R8 is -halo; and R9 is -H. In another embodiment, R8 is -CI. In another embodiment, R8 is -Br. In another embodiment, R8 is -F.
Li another embodiment, n, p, and m are 0; - is -CI, -Br, or -I; x is 0; R4 is -H; R8 is -H; and R9 is -CH3.
In another embodiment, n, p, and m are 0; R1 is -CI; x is 0; R4 is -H; R8 is -H; andR9is-CH^.
In another embodiment, n, p, and m are 0; R1 is -CI, -Br, or -I; x is 0; R4 is -H; R8 is -CH3; and R9 is -H.
In another embodiment, n, p, and m are 0; R1 is -CI; x is 0; R4 is -H; R8 is -CH3; and R, is -H.
In another embodiment, n, p, and m are 0; - is -CI, -Br, or -I; x is 0; R4 is -H; R9is -H; and R9 is -CF3.
Li another embodiment, n, p, and m are 0; R, is -CI; x is 0; R4 is -H; R8 is -H; and R9 is -CF3.
Li another embodiment, n, p, and m are 0; R1 is -CI, -Br, or -I; x is 0; R4 is -H; R8 is -CF3; and R9, is -H.
Li another embodiment, n, p, and m are 0; R1 is -CI; x is 0; R4 is -H; R8 is

IF3; and R9 is »H.
In another embodiment, n, p, and m are 0; R, is -CI, -Br, or -I; x is 0; R4 is -H; g is -H; and R. is -OCH2CH3,
In another embodiment, n, p, and m are 0; Rt is -CI; x is 0; R4 is -H; R8 is -H; id R9 is -OCH2CH3.
In another embodiment, n, p, and m are 0; - is -CI, -Br, or -I; x is 0; R4 is -H; 8 is -OCH2CH3; and R9 is -H.
In another embodiment, n, p, and m are 0; Ri is -CI; x is 0; R4 is -H; R8 is 3CH2CH3; and R, is -H.
In another embodiment, n, p, and m are 0; R} is -CH3, x is 0; R4 is -H, and R8 ad Rn are -H.
In another embodiment, n, p, and m are 0; R1 is -CH3, x is 0; R4 is -H, R8 is -H, ndRnis-halo. In another embodiment, R9, is -CL In another embodiment, R9 is -Br. In nother embodiment, R9 is -F.
In another embodiment, n, p, and m are 0; R, is -CH3, x is 0; R4 is -H, R8 is halo, and R9 is -H, In another embodiment, R9is -CL In another embodiment, R9is -Br. In mother embodiment, R8 is -F.
In another embodiment, n, p, and m are 0; R1 is -CH3, x is 0; R4 is -H, R9is -H, aid R9 is -CH3.
In another embodiment, n, p, and m are 0, R1 is -CH3, x is 0, R4 is -H, R8 is -DH3, and R9, is -H.
In another embodiment, n, p, and m are 0, R1 is -CH3, x is 0, R4 is -H, R8 is -H, and R9 is -CF3.
In another embodiment, n, p, and m are 0, - is -CH3, x is 0, R4 is -H, R8 is -CF3, and R9 is -H.
In another embodiment, n, p, and m are 0, Ri is -CH3, x is 0, R4 is -H, R8 is -H5 and R9 is -OCH2CH3,
In another embodiment, n, p, and m are 0, R, is -CH3, x is 0, R4 is -H, R8 is -OCH2CH3, and R9 is -H.
In another embodiment, n, p, and m are 0, R1 is -CF3, x is 0, R9 is -H, and R8 and Rn are -H.

In another embodiment, n, p, and m are 0, R1 is -CF3, x is 0, R4 is -H, R8 is -H, id R9 is -halo. In another embodiment, R9 is-CI. In another embodiment, R9 is-Br. In lother embodiment, R9 is -F.
In another embodiment, n, p, and m are 0, R1 is -CF3, x is 0, R4 is -H, R8 is lalo, and R9 is -H. In another embodiment, R9is -CI. In another embodiment, R9is -Br. In aother embodiment, R8 is -F.
In another embodiment, n, p, and m are 0, - is -CF3, x is 0, R4 is -H, R8 is -H, nd K is -CH3.
hi another embodiment, n, p, and m are 0, - is -CF3, x is 0, R4 is -H, R8 is CH3, and & is -H.
In another embodiment, n, p, and m are 0, R1 is -CF3, x is 0, R4 is -H, R8 is -H, ind R9 is -CF3.
In another embodiment, n, p, and m are 0, R1 is -CF3, x is 0, R4 is -H, R8 is CF3, and R9 is -H.
In another embodiment, n, p, and m are 0, R, is -CF3, x is 0, R9 is -H, R8 is -H, md R, is -OCH2CH3.
In another embodiment, n, p, and m are 0, R, is -CF3, x is 0, R4 is -H, R9is ■OCH2CH3, and R9 is -H.
In another embodiment, n, p, and m are 0; R, is -CI, -Br, or -I; x is 0; R4 is -H; R8 is -tert-butyl; and R9 is -H.
In another embodiment, n, p, and m are 0; R1 is -CI; x is 0; R4 is -H; R8 is -tert-butyl; and R9 is -H.
In another embodiment, n, p, and m are 0; R, is -CI, -Br, or -I; x is 0; R4 is -H; R8 is -H; and R9 is -tert-butyl.
In another embodiment, n, p, and m are 0; R{ is -CI; x is 0; R4 is -H; R8 is -H; and R9 is -tert-butyl.
In another embodiment, n, p, and m are 0, - is -CH3, x is 0, R4 is -H, R8 is ~tert-butyl9 and R9 is -H.
In another embodiment, n, p, and m are 0, - is -CH3, x is 0, R4 is -H, R8 is -H, andl^ is -tert-butyl.
In another embodiment, n, p, and m are 0, R1 is -CH3, x is 0, R4 is -H, R8 is

-CH3, and R, is -CH3.
In another embodiment, n and p are 0; m is 1; - is -CI, -Br, or -I; x is 0; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group; and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1, - is -CI; x is 0; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; R5 is -CI, -Br, or -I; x is 0; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group; R8 is -H; and R9 is -halo. In another embodiment R9 is -CI. In another embodiment, 1^ is -Br. In another embodiment, R9 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; R1 is -CI; x is 0; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group; R8 is -H; and R9 is -halo. In another embodiment R9 is -CI. In another embodiment, R9 is -Br. In another embodiment, R9 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; R1 is -CI, -Br, or -I; x is 0; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group; R8 is -halo; and 11$ is -H. In another embodiment R8 is -CI. In another embodiment, R8 is -Br. In another embodiment, R8 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. Li another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1, - is -CI; x is 0; R4 is -H; R3 is

CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the Denzooxazolyl group; R8 is -halo; and R9 is -H. In another embodiment R8 is -CI. In another embodiment, R8 is -Br. In another embodiment, Rs is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; R1 is -CI, -Br, or -I; x is 0; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group; R8 is -H; and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1, R1 is -CI; x is 0; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group; R8 is -H; and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; Ri is -CI, -Br, or -I; x is 0; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group; R8 is -CH3, and Rp is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; R1 is -CI; x is 0; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group; R8 is -CH3; and RQ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p 0; m is 1; R1 is -CI, -Br, or -I; x is 0; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group; R8 is -H; and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, n and p 0; m is 1; R1 is -CI; x is 0; R4 is -H; R3 is -CH: aid is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl jR9up; R8 is -H; and R9 is -CF3. In another embodiment, the carbon atom to which the R3 jR9up is attached has the R configuration. In another embodiment, the carbon atom to which he R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; - is -CI, -Br, or -I; x is 0; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group; R8 is -CF3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; - is -CI; x is 0; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group; R8 is -CF3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; - is -CI, -Br, or -I; x is 0; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group; R8 is -H; and 1^ is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; R1 is -CI; x is 0; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group; R8 is -H; and Rp is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; - is -CI, -Br, or -I; x is 0; R4 is -H; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group; R8 is -OCH2CH3; and R9, is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; R, is -CI; x is 0; R4 is -H; R3 is

^H3 and is attached to the carbon atom adjacent to the nitR9gen attached to the enzooxazolyl group; R8 is -OCH2CH3; and R9 is -H. In another embodiment, the carbon torn to which the R3 group is attached has the R configuration. In another embodiment, the arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, R1 is -CH3, x is 0, R4 is -H, R3 is CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the enzooxazolyl group, and R8 and R9 are -H. In another embodiment, the carbon atom to vhich the R3 group is attached has the R configuration. In another embodiment, the carbon ttom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, TLX is -CH3, x is 0, R4 is -H, R3 is CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R8 is -H, and R9 is -halo. In another embodiment R9 is -CI. In another embodiment, R9 is -Br. In another embodiment, R9 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, - is -CH3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R8 is -halo, and R9 is -H. In another embodiment R8 is -CI. In another embodiment, R8 is -Br. In another embodiment, R8 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, Ri is -CH3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R8 is -H, and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, - is -CH3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R8 is -CH3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, n and p are 0, m is 1, R, is -CH3, x is 0, R4 is -H, R3 is :H3 and is attached to the carbon atom adjacent to the nitR9gen attached to the aizooxazolyl group, R8 is -H, and R9is -CF3. In another embodiment, the carbon atom to hich the R3 group is attached has the R configuration. In another embodiment, the carbon om to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, - is -CH3, x is 0, R4 is -H, R3 is DH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the enzooxazolyl group, R9is -CF3, and R9is -H. In another embodiment, the carbon atom to rtiich the R3 group is attached has the R configuration. In another embodiment, the carbon torn to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, R1 is -CH3, x is 0, R4 is -H, R3 is CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the enzooxazolyl group, R9is -H, and R9is -OCH2CH3. In another embodiment, the carbon ttom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, R1 is -CH3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R8 is -OCH2CH3, and R9is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, R1 is -CF3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, and R8 and R9are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, R1 is -CF3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R8 is -H, and R9 is -halo. In another embodiment R9is -CI. In another embodiment, R9is -Br. In another embodiment, R9is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, n and p are 0, m is 1, R1 is -CF3, x is 0, R4 is -H, R3 is CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the enzooxazolyl group, R8 is -halo, and R9 is -H. In another embodiment R8 is -CI. In another embodiment, R8 is -Br. In another embodiment, R8 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, - is -CF3, x is 0, R4 is -H, R3 is •CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to theenzooxazolyl group, R8 is -H, and 1^ is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, - is -CF3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R8 is -CH3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, R1 is -CF3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R8 is -H, and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, - is -CF3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R8 is -CF3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, - is -CF3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, Rs is -H, and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, n and p are 0, m is 1, R1 is -CF3, x is 0, R4 is -H, R3 is i3 and is attached to the carbon atom adjacent to the nitR9gen attached to the lzooxazolyl group, R8 is -OCH2CH3, and *R9 is -H. In another embodiment, the carbon m to which the R3 group is attached has the R configuration. In another embodiment, the :bon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; R1 is -CI, -Br, or -I; x is 0; R3 is H3 and is attached to the carbon atom adjacent to the nitR9gen attached to the nzooxazolyl group; R4 is -H, R8 is -terf-butyl, and R9 is -H. In another embodiment, the rbon atom to which the R3 group is attached has the R configuration. In another abodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; - is -CI; x is 0; R3 is -CH3 and attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group; 4 is -H; R8 is -tert-butyl; and R9 is -H. In another embodiment, the carbon atom to which the 3 group is attached has the R configuration. In another embodiment, the carbon atom to fhich the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; R1 is -CI, -Br, or -I; x is 0; R3 is 3H3 and is attached to the carbon atom adjacent to the nitR9gen attached to the enzooxazolyl group; R4 is -H; R8 is -H; and R9 is -te/-f-butyl. In another embodiment, the arbon atom to which the R3 group is attached has the R configuration. In another mbodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0; m is 1; R1 is -CI; x is 0; R3 is -CH3 and s attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group; l4 is -H; R8 is -H; and R9 is -tert-butyl. In another embodiment, the carbon atom to which the El3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, Rt is -CH3, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R4 is -H, Rs is -te/**-butyl, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, n and p are 0, m is 1, R1 is -CH3, x is 0, R3 is -CH3 and attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, i is -H, Rs is -H, and R9 is -terf-butyl. In another embodiment, the carbon atom to which the t group is attached has the R configuration. In another embodiment, the carbon atom to bich the R3 group is attached has the S configuration.
In another embodiment, n and p are 0, m is 1, R, is -CH3, x is 0, R3 is -CH3 and attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, 4 is -H, R8 is -CH3, and R9 is -CH3. In another embodiment, (he carbon atom to which the R3 R9up is attached has the R configuration. In another embodiment, the carbon atom to which le R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group; n is 0; m is 1; R1 is -CH3, -CI, Br, or -I; x is 1; A is -C(0)-N(R4)-; R3 is -CH3 and is attached to the carbon atom adjacent to tie nitR9gen attached to the -C(0)-N(R4)- group; R4 is -H; R8 is -H; and R9 is -halo. In nother embodiment, the carbon atom to which the R3 group is attached has the R configuration.
In another embodiment, Ar, is a pyridyl group, n is 0, m is 1, Rt is »CH3, x is L, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen ittached to the -C(0)-N(R4)- group, R4 is -H, R8 is -H, and R9 is -Cl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration.
In another embodiment, A- is a pyridyl group; n is 0; m is 1; R1 is -Cl, -Br, or -I; x is 1; A is -C(0)-N(R4)-; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group; R4 is -H; R8 is -H; and R9 is -Br. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration.
In another embodiment, Axx is a pyridyl group, n is 0, m is 1, R1 is -Cl, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R4 is -H, R8 is -H, and R9is -Br. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration.
In another embodiment, Axx is a pyridyl group, n is 0, m is 1, - is -CH3, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4 group, R4 is -H, R8 is -H, and R9 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration.

In another embodiment, Ax{ is a pyrimidinyl group; p is 0; m is 1; R1 is -CH3, HI, -Br, -I; x is 1; A is -C(0)-N(R4)s R3 is -CH3 and is attached to the carbon atom adjacent 3 the mtR9gen attached to the -C(0)-N(R4 group; R4 is -H; R8 is -H; and R9 is -halo. In nother embodiment, the carbon atom to which the R3 group is attached has the R onfiguration.
In another embodiment, AXj is a pyrimidinyl group, p is 0, m is 1, R, is -CH3, x s 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen ittached to the -C(0)-N(R4)- group, R4 is -H, R8 is -H, and R9, is -CI. In another embodiment, he carbon atom to which the R3 group is attached has the R configuration.
In another embodiment, Ar1 is a pyrimidinyl group; p is 0; m is 1; - is -CI, Br, or -I; x is 1; A is »C(0)-N(R4)-; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group; R4 is -H; R9is -H; and R9 is -Br. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration.
In another embodiment, AR1 is a pyrimidinyl group, p is 0, m is 1, - is -CI, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R4 is -H, R8 is -H, and R9 is -Br. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration.
In another embodiment, A^ is a pyrimidinyl group, p is 0, m is 1, - is -CH3, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C^-N^)- group, R4 is -H, R8 is -H, and R9» is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration.
In another embodiment, Ar, is a pyridyl group; n is 0; m is 1; R1 is -CH3, -CI, -Br, or -I; x is 0; R3 is -CH3 and is attached to the carbon atom adjacent to the mtR9gen attached to the benzooxazolyl group; R4 is -H; R8 is -H; and 1^ is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration.
In another embodiment, Ar, is a pyridyl group, n is 0, m is 1, - is -CH3, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R4 is -H, R9is -H, and R9 is -CI. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration.
In another embodiment, Ar1 is a pyridyl group; n is 0; m is 1; - is -CI, -Br, or »I; x is 0; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to

e benzooxazolyl group; R4 is -H; R8 is -H; and is -Br. In another embodiment, the irbon atom to which the R3 group is attached has the R configuration.
In another embodiment, AR1 is a pyridyl group, n is 0, m is 1, R1 is -CI, x is 0, 3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the snzooxazolyl group, R4 is -H, Rs is -H, and R9» is -Br. In another embodiment, the carbon ;om to which the R3 group is attached has the R configuration.
In another embodiment, A- is a pyridyl group, n is 0, m is 1, R1 is -CH3, x is , R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the enzooxazolyl group, R4 is -H, R8 is -H, and R9 is -F. In another embodiment, the carbon torn to which the R3 group is attached has the R configuration.
In another embodiment, AR1 is a pyrimidinyl group; p is 0; m is 1; R1 is -CH3, Cl» -Br, or -I; x is 0; R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen Lttached to the benzooxazolyl group; R4 is -H; R8 is -H; and R9 is -halo. In another smbodiment, the carbon atom to which the R3 group is attached has the R configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0, m is 1, R1 is -CH3, x s 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R4 is -H, R8 is -H, and R9 is -CI. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration.
In another embodiment, Art is a pyrimidinyl group; p is 0; m is 1; R1 is -CI, -Br, or -I; x is 0; R3 is -CH3 and is attached to the carbon atom adjacent to the mtR9gen attached to the benzooxazolyl group; R4 is -H; R8 is -H; and R9 is -Br. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration.
In another embodiment, Ax{ is a pyrimidinyl group, p is 0, m is 1, - is -CI, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R4 is -H, R8 is -H, and 1^ is -Br. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0, m is 1, - is -CH3, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R4 is -H, R8 is -H, and R9 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration.

In another embodiment, m is 1 and R3 is -(C1-C4)alkyl and is attached to the arbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4 or the benzooxazolyl R9up. In another embodiment, m is 1 and R3 is -(C1-C4)alkyl and is attached to the carbon torn adjacent to the nitR9gen attached to the -C(0)-N(R4 or the benzooxazolyl group and le carbon to which the R3 group is attached is in the R configuration.
In another embodiment, m is 1 and R3 is -CH3 and is attached to the carbon torn adjacent to the nitR9gen attached to the -C(0)-N(R4 or the benzooxazolyl group. In mother embodiment, m is 1 and R3 is -CH3 and is attached to the carbon atom adjacent to the utR9gen attached to the -C(0)-N(R4)- or the benzooxazolyl group and the carbon to which the l3 group is attached is in the R configuration.
In another embodiment, m is 1 and R3 is -(C1-C4)alkyl and is attached to the :arbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- or the benzooxazolyl group. In another embodiment, m is 1 and R3 is -(C1-C4)alkyl and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- or the benzooxazolyl group and the carbon to which the R3 group is attached is in the S configuration.
In another embodiment, m is 1 and R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- or the benzooxazolyl group. In another embodiment, m is 1 and R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- or the benzooxazolyl group and the carbon to which the R3 group is attached is in the S configuration.
In another embodiment, m is 1 and R3 is -(C1-C4)alkyl and is attached to the carbon atom adjacent to the nitR9gen attached to the pyridyl group or pyrimidinyl group. In another embodiment, m is 1 and R3 is -(C1-C4)alkyl and is attached to the carbon atom adjacent to the nitR9gen attached to the pyridyl group or pyrimidinyl group and the carbon to which the R3 group is attached is in the R configuration.
In another embodiment, m is 1 and R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the pyridyl group or pyrimidinyl group. In another embodiment, m is 1 and R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the pyridyl group or pyrimidinyl group and the carbon to which the R3 group is attached is in the R configuration.

In another embodiment, m is 1 and R3 is -(Cl-C4)alkyl and is attached to the carbon atom adjacent to the nitR9gen attached to the pyridyl group or pyrimidinyl group. In mother embodiment, m is 1 and R3 is -(C1-C4)alkyl and is attached to the carbon atom idjacent to the nitR9gen attached to the pyridyl group or pyrimidinyl group and the carbon to which the R3 group is attached is in the S configuration.
In another embodiment, m is 1 and R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the pyridyl group or pyrimidinyl group. In another embodiment, m is 1 and R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the pyridyl group or pyrimidinyl group and the carbon to which the R3 group is attached is in the S configuration.

and pharmaceutical^ acceptable salts thereof, where AR9 R3, R8, R9 A, x, and m, are defined above for the Benzoazolylpiperazine Compounds of formula (mb).
In one embodiment, AR1 is a pyrazinyl group.
In another embodiment, Axx is a pyridazinyl group.
In another embodiment, Axx is a thiazanyl group.
In another embodiment, x is 1 and A is -C(0)-N(R4)-.
In another embodiment, x is 1 and A is -C(S)-N(R4)-.
In another embodiment x is 0.

In another embodiment, x is 1.
In another embodiment, p is 0.
In another embodiment, p is 1.
In another embodiment, m is 0.
In another embodiment, m is 1.
In another embodiment, Ar, is a pyrazinyl group, x is 1, and A is -C(0)N(R4)-.
In another embodiment, Ar1 is a pyrazinyl group, x is 1, and A is -C(S)N(R4)-.
In another embodiment, Ar1 is a pyridazinyl group, x is 1, and A is -C(0)N(R4.
In another embodiment, Ar, is a pyridazinyl group, x is 1, and A is -C(S)N(R4)-.
In another embodiment, A- is a thiazanyl group, x is 1, and A is -C(0)N(R4)-.
In another embodiment, Ar1 is a thiazanyl group, x is 1, and A is -C(S)N(R4)-.
In another embodiment, R1 is -H.
In another embodiment, R1 is -CI.
In another embodiment, R, is -Br.
In another embodiment, R1 is -L
In another embodiment, - is -F.
In another embodiment, - is -(C1-C6)alkyl.
In another embodiment, R1 is -CH3.
In another embodiment, R1 is -N02.
In another embodiment, - is -CN.
In another embodiment, R1 is -OH.
In another embodiment, R1 is -OCH3.
In another embodiment, is -NH2.
In another embodiment, R, is -C(halo)3.
In another embodiment, R1 is -CH(halo)2.
In another embodiment, R1 is -CH2(halo).
In another embodiment, p is 1 and R2 is -halo, -CN, -OH, -0(C1-C6)alkyl, -N02, or -NH2.

In another embodiment, p is 1 and R2 is -(Cj-C10)alkyl, -(C2-C10)alkenyl, -(C2-10)alkynyl, -(C3-C10)cycloalkyl, -(C8-CM)bicycloalkyl, ~(Cs-C14)tricycloalkyl, -(C5« 10)cycloalkenyl,-(C8-Cl4)bicycloalkenyl, -(C8-C14)tricycloalkenyl, -(3- to 7-Lembered)heteR9cycle, or -(7- to 10-membered)bicycloheteR9cycle, each of which is asubstituted or substituted with one or more - groups.
In another embodiment, p is 1 and R2 is -phenyl, -naphthyl, -(C14)aryl, or -(5- 10-membered)heteR9aryl, each of which is unsubstituted or substituted with one or more R9 R9ups;
In another embodiment, m is 1 and R3 is -halo, -CN, -OH, -0(CVC6)alkyl, N02, or -NH2.
In another embodiment, m is 1 and R3 is -C1-C10alkyl, -(C2-C10)alkenyl, -(C2-:]0)alkynyl, -(C3-C10)cycloalkyl, -(C8-C14)bicycloalkyl, -(C8-C14)tricycloalkyl, -(C5-i;10)cycloalkenyl,-(C8-Ci4)bicycloalkenyl, -(C8-C14)tricycloalkenyl, -(3- to 7-nembered)heteR9cycle, or -(7- to 10-membered)bicycloheteR9cycle, each of which is ansubstituted or substituted with one or more Rs groups.
In another embodiment, m is 1 and R3 is -phenyl, -naphthyl, -(C14)aryl or -(5-to 10-membered)heteR9aryl, each of which is unsubstituted or substituted with one or more R9groups.
In another embodiment, R4 is -H.
In another embodiment, R4 is -(C1-C6)alkyl.
In another embodiment, R8 and R9 are each independently -H, halo, -(Cr C6)alkyl, -0(C1-C6)alkyl, -C(halo)3, -CH(halo)2, or -CH2(halo).
In another embodiment, at least one of R8 or 11$ is -H.
In another embodiment, p and m are 0, Rt is -halo, x is 1, A is -C(0)~N(R4)-, R4 is -H, and R8 and R9 are -H.
In another embodiment, p and m are 0, - is -CI, x is 1, A is -C(0)-N(R4)-, R4 is -H, and R9and R9 are -H.
In another embodiment, p and m are 0, is -halo, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -H, and R9 is -halo. In another embodiment, R9 is -CI. In another embodiment, R9 is -Br. In another embodiment, R9 is -F.

In another embodiment, p and m are 0, - is -CI, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -H, and R9is -halo. In another embodiment, R9 is -CI. In another embodiment, R9is -Br. In another embodiment, R9is -F.
In another embodiment, p and m are 0, - is -halo, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -halo, and R9is -H. In another embodiment, R8 is -CI. In another embodiment, R8 is -Br. In another embodiment, R8 is -F.
In another embodiment, p and m are 0, R, is -CI, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -halo, and R9is -H. In another embodiment, R8 is -CI. In another embodiment, R8 is -Br. In another embodiment, R8 is -F.
In another embodiment, p and m are 0, R} is -halo, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -H, and R9is -CH3.
In another embodiment, p and m are 0, - is -CI, x is 1, A is -C(0)-N(R4)-, R4 is -H, R9is -H, and R9is -CH3.
In another embodiment, p and m are 0, R} is -halo, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -CH3, and R9is -H.
In another embodiment, p and m are 0, R1 is -CI, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -CH3, and R9 is -H.
In another embodiment, p and m are 0, - is -halo, x is 1, A is -C(0)-N(R4)~, R4 is -H, R8 is -H, and R9is -CF3.
In another embodiment, p and m are 0, R1 is -CI, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -H, and R9is -CF3.
In another embodiment, p and m are 0, - is -halo, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -CF3, and R9is -H.
In another embodiment, p and m are 0, R1 is -CI, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -CF3, and R9is -H.
In another embodiment, p and m are 0, - is -halo, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -H, and R9is -OCH2CH3.
In another embodiment, p and m are 0, R1 is -CI, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -H, and R9is -OCH2CH3.
In another embodiment, p and m are 0, R, is -halo, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -OCH2CH3, and R9is -H.

In another embodiment, p and m are 0, - is -CI, x is 1, A is -C(0)-N(R4)-, R4 s -H, R8 is -OCH2CH3, and R9 is -H.
In another embodiment, p and m are 0, R, is -CH3, x is 1, A is -C(0)-N(R4)-, l4 is -H, and R8 and R9 are -H.
In another embodiment, p and m are 0, - is -CH3, x is 1, A is -C(0)-N(R4)-, i4 is -H, R8 is -H, and R9 is -halo. In another embodiment, R9 is -CI. In another embodiment is -Br. In another embodiment, R9 is -F.
In another embodiment, p and m are 0, - is -CH3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -halo, and R9 is -H. In another embodiment, R8 is -CI. In another embodiment, R8 is -Br. In another embodiment, R8 is -F.
In another embodiment, p and m are 0, R1 is -CH3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -H, and R9 is -CH3.
In another embodiment, p and m are 0, Rt is -CH3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -CH3, and R9 is -H.
In another embodiment, p and m are 0, R1 is -CH3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -H, and R, is -CF3.
In another embodiment, p and m are 0, Ri is -CH3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -CF3, and R9, is -H.
In another embodiment, p and m are 0, R1 is -CH3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -H, and R9, is -OCH2CH3.
In another embodiment, p and m are 0, Rl is -CH3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -OCH2CH3, and R, is -H.
In another embodiment, p and m are 0, R1 is -CF3, x is 1, A is -C(0)-N(R4)-, R4 is -H, and R9and R9 are -H.
In another embodiment, p and m are 0, R1 is -CF3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -H, and R9 is -halo. In another embodiment, R9 is -CI. In another embodiment, R9 is -Br. In another embodiment, R9 is -F.
In another embodiment, p and m are 0, R, is -CF3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -halo, and 1^ is -H. In another embodiment, R8 is -CI. In another embodiment, Rs is -Br. In another embodiment, R8 is -F.

In another embodiment, p and m are 0, R, is -CF3, x is 1, A is -C(0)-N(R4, i is -H, R8 is -H, and R9, is -CH3.
In another embodiment, p and m are 0, R, is -CF3, x is 1, A is -C(0)-N(R4K % is -H, R8 is -CH3, and R9 is -H.
In another embodiment, p and m are 0, R1 is -CF3, x is 1, A is -C(0)-N(R4)-, 4 is -H, R8 is -H, and R9is -CF3.
In another embodiment, p and m are 0, is -CF3, x is 1, A is -C(0)-N(R4)-, 4 is -H, R8 is -CF3, and R9is -H.
In another embodiment, p and m are 0, R1 is -CF3, x is 1, A is -C(0)-N(R4)-, .4 is -H, R8 is -H, and R9 is -OCH2CH3.
In another embodiment, p and m are 0, R1 is -CF3, x is 1, A is -C(0)-N(R4)-, L4 is -H, R8 is -OCH2CH3, and R9 is -H.
In another embodiment, p and m are 0, - is -halo, x is 1, A is -C(0)-N(R4)-, L4 is -H, R8 is -tert-butyl, and R9is -H.
In another embodiment, p and m are 0, is -CI, x is 1, A is -C(0)-N(R4)-, R4 s -H, R8 is -fert-butyl, and R9 is -H.
In another embodiment, p and m are 0, R1 is -halo, x is 1, A is -C(0)-N(R4)-, l4 is -H, R8 is -H, and R9is -terf-butyl.
In another embodiment, p and m are 0, - is -CI, x is 1, A is -C(0)-N(R4)-, R4 s -H, R8 is -H, and R9is -fert-butyl.
In another embodiment, p and m are 0, R1 is -CH3, x is 1, A is -C(0)-N(R4)-, R4 is -H, Rs is -tent-butyl, and R9is -H.
In another embodiment, p and m are 0, R1 is -CH3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -H, and R9is -fert-butyl.
In another embodiment, p and m are 0, Rt is -CH3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R8 is -CH3, and R9is -CH3.
In another embodiment, p is 0, m is 1, R1 is -halo, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, and R8 and R9are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, p is 0, m is 1, R, is -CI, x is 1, A is -C(0)-N(R4)-, R4 -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the XO)-N(R4 group, and R8 and R9 are -H. In another embodiment, the carbon atom to which le R3 group is attached has the R configuration. In another embodiment, the carbon atom to hich the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -halo, x is 1, A is -C(0)-N(R4)-, R4 ; -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the 3(0)-N(R4)- group, R9is -H, and R9, is -halo. In another embodiment, R9 is -CI. In another mbodiment, It, is -Br. In another embodiment, R9 is -F. In another embodiment, the carbon torn to which the R3 group is attached has the R configuration. In another embodiment, the arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R{ is -CI, x is 1, A is -C(0)-N(R4)-, R4 s -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the C(0)-N(R4)- group, RS is -H, and R9 is -halo. In another embodiment, R9 is -CI. In another embodiment, 11$ is -Br. In another embodiment, R9 is -F. In another embodiment, the carbon itom to which the R3 group is attached has the R configuration. In another embodiment, the ;arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -halo, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R9is -halo, and R9 is -H. In another embodiment, R8 is -CI. In another embodiment, R8 is -Br. In another embodiment, R8 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CI, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to.the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -halo, and R? is -H. In another embodiment, R8 is -Cl. In another embodiment, R9is -Br, In another embodiment, R8 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R{ is -halo, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the

:(0)-N(R4)- group, R8 is -H, and R9 is -CH3. In another embodiment, the carbon atom to hich the R3 group is attached has the R configuration. In another embodiment, the carbon om to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CI, x is 1, A is -C(0)-N(R4)-, R4 -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the 3(0)-N(R4)- group, R8 is -H, and R9 is -CH3. In another embodiment, the carbon atom to 'hich the R3 group is attached has the R configuration. In another embodiment, the carbon torn to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -halo, x is 1, A is -C(0)-N(R4)-, R4 5 -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the C(0)-N(R4)- group, R8 is -CH3, and R9 is -H. In another embodiment, the carbon atom to vhich the R3 group is attached has the R configuration. In another embodiment, the carbon Ltom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R] is -CI, x is 1, A is -C(0)-N(R4)-, R4 s -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R9is -CH3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -halo, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -H, and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CI, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -H, and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, Rt is -halo, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the

-C(0)-N(R4)- group, R8 is -CF3, and R9, is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, Rt is -CI, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -CF3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R} is -halo, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, RS is -H, and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -CI, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -H, and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -halo, x is 1, A is -C(0)-N(R4)-, R+ is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -OCH2CH3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CI, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -OCH2CH3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CH3, x is 1, A is -C(0)-N(R4)-, R4 1 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the

"(0N(R4)- group, and R8 and R9 are -H. In another embodiment, the carbon atom to which le R3 group is attached has the R configuration. In another embodiment, the carbon atom to rtrich the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, Rt is -CH3, x is 1, A is -C(0)-N(R4)-, R4 3 -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the C(0)-N(R4)- group, R9is -H, and R9 is -halo. In another embodiment R9 is -CI. In another mbodiment, R9 is -Br. In another embodiment, R9is -F. In another embodiment, the carbon itom to which the R3 group is attached has the R configuration. In another embodiment, the ;arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CH3, x is 1, A is -C(0)-N(R4)-, R4 s -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the C(0)-N(R4)- group, R8 is -halo, and R9 is -H. In another embodiment R8 is -Cl. In another embodiment, R8 is -Br. In another embodiment, R8 is -F. In another embodiment, the carbon itom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -CH3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -H, and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CH3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -CH3, and is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CH3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -H, andR9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, p is U, m is l, Kj IS -^n3, Aiai,nW "uvvrn^4y,4 -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the XO)~N(R4)- group, R8 is -CF3, and Rs is -H. In another embodiment, the carbon atom to hich the R3 group is attached has the R configuration. In another embodiment, the carbon om to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, Rt is -CH3, x is 1, A is -C(0)-N(R4)-, R4 -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the 3(0)-N(R4)- group, R9is -H, and R9 is -OCH2CH3. In another embodiment, the carbon atom which the R3 group is attached has the R configuration. In another embodiment, the carbon torn to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CH3, x is 1, A is -C(0)-N(R4)-, R4 s -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the C(0)-N(R4)- group, R8 is -OCH2CH3, and R9 is -H. In another embodiment, the carbon atom o which the R3 group is attached has the R configuration. In another embodiment, the carbon itom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CF3, x is 1, A is -C(0)-N(R4)-, R4 s -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the C(0)-N(R4)- group, and R8 and R9 are -H. In another embodiment, the carbon atom to which he R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, -L is -CF3, x is 1, A is -C(0)-N(R4)-, R4 is ~H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -H, and R9 is -halo. In another embodiment R9 is -Cl. In another embodiment, R9is -Br. In another embodiment, R9 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CF3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -halo, and R9 is -H. In another embodiment R8 is -Cl. In another embodiment, Rs is -Br. In another embodiment, R8 is -F. In another embodiment, the carbon

om to which the R3 group is attached has the R configuration. In another embodiment, the irbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CF3, x is 1, A is -C(0)-N(R4)-, R4 -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the XO)-N(R4)- group, R8 is -H, and R9 is -CH3. In another embodiment, the carbon atom to hich the R3 group is attached has the R configuration. In another embodiment, the carbon :om to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, Rt is -CF3, x is 1, A is -C(0)-N(R4)-, R4 -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the C(0)-N(R9)- group, R9is -CH3, and R9 is -H. In another embodiment, the carbon atom to /hich the R3 group is attached has the R configuration. In another embodiment, the carbon torn to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, Rt is -CF3, x is 1, A is -C(0)-N(R4)-, R4 s -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the C(0)-N(R4)- group, Rs is -H, and£9 is -CF3. In another embodiment, the carbon atom to vhich the R3 group is attached has the R configuration. In another embodiment, the carbon itom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R: is -CF3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R8 is -CF3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CF3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R9is -H, and R9, is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CF3, x is 1, A is -C(0)-N(R4)-, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the

C(0)-N(R4)- group, R8 is -OCH2CH3, and R9, is -H. In another embodiment, the carbon atom : which the R3 group is attached has the R configuration. In another embodiment, the carbon torn to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is halo, x is 1, A is -C(0)-N(R4)-, R3 s -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(O)-^T(R4 group, R4 is -H, R8 is -fer/-butyl, and R9, is -H. In another embodiment, the carbon Ltom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R} is -CI, x is 1, A is -C(0)-N(R4)-, R3 s -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(O)-Sf(R4)- group, R4 is -H, R8 is -tert-butyl, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the :arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -halo, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R4 is ~H, R8 is -H, and R9 is -/erf-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CI, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(O)-N(R4)- group, R4 is -H, R9is -H, and R9is -fert-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CH3, x is 1, A is -C(0)-N(R9)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(O)-N(R4)- group, R4 is -H, R8 is -tert-butyl, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CH3, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(O)-N(R4)- group, R4 is -H, R8 is -H, and R9 is -tert-butyl. In another embodiment, the carbon

atom to which the R3 group is attached has the R configuration, hi another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CH3, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(O)-Nf(R4)- group, R4 is -H, R8 is -CH3, and R9, is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p and m are 0, R1 is -halo, x is 0, R4 is -H, and R8 and R9 are -H.
In another embodiment, p and m are 0, R, is -CI, x is 0, R4 is -H, and R9and R9 are-H.
In another embodiment, p and m are 0, - is -halo, x is 0, R4 is -H, R8 is -H, and R9 is -halo. In another embodiment, R9 is -CI. In another embodiment, R? is -Br. In another embodiment, R9 is -F.
In another embodiment, p and m are 0, R1 is -CI, x is 0, R4 is -H5 R8 is -H, and Rs is-halo. In another embodiment, R? is -CI. In another embodiment, R9 is -Br. In another embodiment, R9, is -F.
In another embodiment, p and m are 0, R1 is -halo, x is 0, R4 is -H, R8 is -halo, and R9 is -H. In another embodiment, R9is -CI. In another embodiment, R8 is -Br. In another embodiment, R8 is -F.
In another embodiment, p and m are 0, Rt is -CI, x is 0, R9 is -H, R8 is -halo, andl^is-H. In another embodiment, R8 is-CI. In another embodiment, R8 is-Br. In another embodiment, R9is -F.
In another embodiment, p and m are 0, R5 is -halo, x is 0, R4 is -H, R8 is -H, and R9, is -CH3.
In another embodiment, p and m are 0, R1 is -CI, x is 0, R4 is -H, R8 is -H, and R9» is -CH3.
In another embodiment, p and m are 0, - is -halo, x is 0, R4 is -H, R8 is -CH3, and R9 is -H.
In another embodiment, p and m are 0, R1 is -CI, x is 0, R4 is -H, R8 is -CH3, and R9is -H.

In another embodiment, p and m are 0, R, is -halo, x is 0, R4 is -H, R8 is -H, Ld R9 is -CF3.
In another embodiment, p and m are 0, R, is -CI, x is 0, R4 is -H, R8 is -H, and 9 is -CF3.
In another embodiment, p and m are 0, R1 is -halo, x is 0, R4 is -H, R8 is -CF3, id R9is -H.
hi another embodiment, p and m are 0, Rt is -CI, x is 0, R4 is -H, Rs is -CF3, id R9 is -H.
In another embodiment, p and m are 0, - is -halo, x is 0, R4 is -H, R8 is -H, ad R9is -OCH2CH3.
In another embodiment, p and m are 0, Ri is -CI, x is 0, R4 is -H, R8 is -H, and Lg is -OCH2CH3.
In another embodiment, p and m are 0, R1 is -halo, x is 0, R4 is -H, R9is OCH2CH3, and R9is-H.
In another embodiment, p and m are 0, R1 is -CI, x is 0, R4 is -H, R8 is OCH2CH3, and R9is -H.
In another embodiment, p and m are 0, R1 is -CH3, x is 0, R4 is -H, and R8 and lg are -H.
In another embodiment, p and m are 0, R1 is -CH3, x is 0, R4 is -H, R8 is -H, and R9is-halo, hi another embodiment, R9is-CI. In another embodiment, R9is-Br. In another embodiment, R9is -F.
Li another embodiment, p and m are 0, R1 is -CH3, x is 0, R4 is -H, R8 is -halo, and R9is -H. In another embodiment, R8 is -CI. In another embodiment, R8 is -Br. In another embodiment, R8 is -F.
In another embodiment, p and m are 0, - is -CH3, x is 0, R4 is -H, R8 is -H, and R9is -CH3.
In another embodiment, p and m are 0, - is -CH3, x is 0, R4 is -H, R8 is -CH3, and R9is -H.
In another embodiment, p and m are 0, - is -CH3, x is 0, R4 is -H, R8 is -H, and R9is -CF3.

In another embodiment, p and m are 0, R1 is -CH3, x is 0, R4 is -H, R8 is -CF3,
I - is -H.
In another embodiment, p and m are 0, R1 is -CH3, x is 0, R4 is -H, R8 is -H,
In another embodiment, p and m are 0, R1 is -CH3, x is 0, R4 is -H, R8 is CH2CH3, and R? is -H.
In another embodiment, p and m are 0, R1 is -CF3, x is 0, R4 is -H, and R8 and
are-H.
In another embodiment, p and m are 0, R1 is -CF3, x is 0, R4 is ~H, R8 is -H, LdR9is-halo. In another embodiment, R9, is -CI. In another embodiment, R9 is -Br. In lother embodiment, R9 is -F.
In another embodiment, p and m are 0, Rl is -CF35 x is 0, R4 is -H, R8 is -halo, ldR9is-H. In another embodiment, Rs is-CI. In another embodiment, R8 is-Br. In lother embodiment, R8 is -F.
In another embodiment, p and m are 0, R1 is -CF3, x is 0, R4 is -H, R8 is -H, ad R9 is -CH3.
In another embodiment, p and m are 0, R1 is -CF3, x is 0, R4 is -H, R8 is -CH3, nd R9 is -H.
In another embodiment, p and m are 0, R1 is -CF3, x is 0, R4 is -H, R8 is -H, ind R9 is -CF3.
In another embodiment, p and m are 0, R1 is -CF3, x is 0, R4 is -H, R8 is -CF3, ind R9 is -H.
In another embodiment, p and m are 0, R, is -CF3, x is 0, R4 is -H, R8 is -H, and R9 is -OCH2CH3.
In another embodiment, p and m are 0, R1 is -CF3, x is 0, R4 is -H, R8 is -OCH2CH3, and R, is -H.
In another embodiment, p and m are 0, is -halo, x is 0, R4 is -H, R8 is -tert-butyl, and R? is -H.
In another embodiment, p and m are 0, R1 is -CI, x is 0, R4 is -H, R8 is -tert-butyl, and R9 is -H.

In another embodiment, p and m are 0, R1 is -halo, x is 0, R4 is -H, R8 is -H, and R9 is -terf-butyl.
In another embodiment, p and m are 0, R1 is -CI, x is 0, R4 is -H, R8 is -H, and R9 is -terf-butyl.
In another embodiment, p and m are 0, R1 is -CH3, x is 0, R4 is -H, R8 is -ten-butyl, and R9 is -H.
In another embodiment, p and m are 0, - is -CH3, x is 0, R4 is -H, R8 is -H, and R9 is -tert-butyl.
In another embodiment, p and m are 0, R1 is -CH3, x is 0, R4 is -H, R8 is -CH3, and R9 is -CH3.
In another embodiment, p is 0, m is 1, Rt is -halo, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, Rt is -CI, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -halo, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R8 is -H, and R9 is -halo. In another embodiment, R9 is -CI. In another embodiment, R9 is -Br. In another embodiment, R9 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -CI, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R8 is -H, and R9 is -halo. In another embodiment, R9 is -CI. In another embodiment, R9is

-Br. In another embodiment, R9 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, Rt is -halo, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R8 is -halo, and R9, is -H. In another embodiment, R9is -CI. In another embodiment, R8 is -Br. In another embodiment, R8 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CI, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R8 is -halo, and R9 is -H. In another embodiment, R8 is -CI. In another embodiment, R8 is -Br, In another embodiment, R9is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, Rt is -halo, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R8 is -H, and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CI, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R8 is -H, and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -halo, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R8 is -CH3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which I the R3 group is attached has the S configuration.

In another embodiment, p is 0, m is 1, - is -CI, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R8 is -CH3, and R9, is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -halo, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R9is -H, and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -CI, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R9is -H, and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -halo, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R8 is -CF3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
hi another embodiment, p is 0, m is 1, R, is -CI, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R8 is -CF3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -halo, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R8 is -H, and Rv is ~OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, p is 0, m is 1, - is -CI, x is 0, R4 is ~H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R8 is -H, and R9is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -halo, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R8 is -OCH2CH3, and R9is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to i which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -CI, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R9is -OCH2CH3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -CH3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, and R8 and R9are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 • group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CH3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R8 is -H, and R9is -halo, hi another embodiment R9is -CI. In another embodiment, R9is -Br. In another embodiment, R9is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -CH3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R8 is -halo, and R9is -H. In another embodiment R8 is -CI. In another embodiment, R8 is -Br. In another embodiment, R8 is -F. In another embodiment, the carbon atom to

which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CH3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R8 is -H, and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CH3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R8 is -CH3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CH3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl i group, R8 is -H, and is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CH3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R8 is -CF3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CH3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R8 is -H, and 1^ is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CH3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R8 is -OCH2CH3, and H? is -H. In another embodiment, the carbon atom to which the

3 group is attached has the R configuration. In another embodiment, the carbon atom to rhich the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, Rl is -CF3, x is 0, R4 is -H, R3 is -CH3 nd is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl R9up, and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 group 5 attached has the R configuration. In another embodiment, the carbon atom to which the R3 ;R9up is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CF3, x is 0, R4 is -H, R3 is -CH3 ind is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl jR9up, R8 is -H, and R9 is -halo. In another embodiment R9, is -CI. In another embodiment, is -Br. In another embodiment, R9 is -F. In another embodiment, the carbon atom to aiiich the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -CF3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R9is -halo, and R? is -H. In another embodiment R8 is -CI. In another embodiment, R8 is -Br. In another embodiment, R8 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -CF3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R8 is -H, and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R{ is -CF3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R8 is -CH3, and R9is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, RY is -CF3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl

group, R8 is -H, and R9, is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, Rt is -CF3, x is 0, R4 is -H, R3 is -CH3 nd is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl ;R9up, R8 is -CF3, and R9, is -H. In another embodiment, the carbon atom to which the R3 jR9up is attached has the R configuration. In another embodiment, the carbon atom to which he R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CF3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R8 is -H, and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, - is -CF3, x is 0, R4 is -H, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R8 is -OCH2CH3, and Rp is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -halo, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R4 is -H, R8 is -terf-butyl, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, Rt is -CI, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R4 is -H, R8 is -terf-butyl, and R? is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R, is -halo, x is 0, R3 is -CH3 and is 1 attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R4 is -H, R9is -H, and R9 is -terf-butyl. In another embodiment, the carbon atom to which the R3

oup is attached has the R configuration. In another embodiment, the carbon atom to which e R3 group is attached has the S configuration
Li another embodiment, p is 0, m is 1, R1 is -CI, x is 0, R3 is -CH3 and is tached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R4 -H, R8 is -H, and R9 is -terf-butyl. In another embodiment, the carbon atom to which the R3 R9up is attached has the R configuration. In another embodiment, the carbon atom to which le R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CH3, x is 0, R3 is -CH3 and is ttached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R4 s -H, R8 is -tot-butyl, and R9 is -H. In another embodiment, the carbon atom to which the R3 pR9up is attached has the R configuration. In another embodiment, the carbon atom to which he R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, Rt is -CH3, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R4 is -H, R8 is -H, and H? is -terf-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, p is 0, m is 1, R1 is -CH3, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R4 is -H, R8 is -CH3, and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyrazinyl group, p is 0, m is 1, JLX is -CH3 or -halo, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R4 is -H, R8 is -H, and R9is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrazinyl group, p is 0, m is 1, Rt is -CH3, x is ' 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R4 is -H, R8 is -H, and R9 is -Cl. In another embodiment,

he carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, A- is a pyrazinyl group, p is 0, m is 1, R1 is -halo, x is I, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen ittached to the -C(0)-N(R4)- group, R4 is -H, R8 is -H, and R9is -Br. In another embodiment, ;he carbon atom to which the R3 group is attached has the R configuration. In another smbodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, A- is a pyrazinyl group, p is 0, m is 1, R1 is -CI, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R4 is -H, R8 is -H, and R9 is -Br. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, A^ is a pyrazinyl group, p is 0, m is 1, R1 is -CH3, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R4 is -H, R8 is -H, and R9is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ai{ is a pyridazinyl group, p is 0, m is 1, R, is -CH3 or -halo, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R4 is -H, R8 is -H, and R9is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridazinyl group, p is 0, m is 1, - is -CH3, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R4 is -H, R8 is -H, and R9 is -Cl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridazinyl group, p is 0, m is 1, R1 is -halo, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4 group, R4 is -H, R8 is -H, and R9 is -Br. In another embodiment,

the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridazinyl group, p is 0, m is 1, R, is -CI, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R4 is -H, R8 is -H, and R9 is -Br. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, A- is a pyridazinyl group, p is 0, m is 1, R1 is -CH3, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R4 is -H, R8 is -H, and R9is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a thiazanyl group, p is 0, m is 1, R1 is -CH3 or -halo, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R4 is -H, R8 is -H, and R9is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a thiazanyl group, p is 0, m is 1, - is -CH3, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R4 is -H, R8 is -H, and R9is -Cl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, A- is a thiazanyl group, p is 0, m is 1, R1 is -halo, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R4 is -H, RS is -H, and 1*9 is -Br. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aji is a thiazanyl group, p is 0, m is 1, R, is -Cl, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R4 is -H, R8 is -H, and R9 is -Br. In another embodiment,

the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a thiazanyl group, p is 0, m is 1, R1 is -CH3, x is 1, A is -C(0)-N(R4)-, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- group, R4 is -H, R9is -H, and R9 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyrazinyl group, p is 0, m is 1, R1 is -CH3 or -halo, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R4 is -H, R8 is -H, and R9, is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrazinyl group, p is 0, m is 1, R1 is -CH3, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R4 is -H, R8 is -H, and B^ is -CI. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrazinyl group, p is 0, m is 1, - is -halo, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R4 is -H, R8 is -H, and R, is -Br. hi another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyrazinyl group, p is 0, m is 1, R1 is -CI, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R4 is -H, R8 is -H, and R9is -Br. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrazinyl group, p is 0, m is 1, R, is -CH3, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R4 is -H, R8 is -H, and R9, is -F. In another embodiment, the carbon

m to which the R3 group is attached has the R configuration. In another embodiment, the rbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridazinyl group, p is 0, m is 1, Rt is -CH3 or alo, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to e benzooxazolyl group, R4 is -H, R8 is -H, and is -halo. In another embodiment, the irbon atom to which the R3 group is attached has the R configuration. In another nbodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridazinyl group, p is 0, m is 1, R1 is -CH3, x s 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the enzooxazolyl group, R4 is -H, R8 is -H, and R9 is -CI. In another embodiment, the carbon torn to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridazinyl group, p is 0, m is 1, - is -halo, x s 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R4 is -H, R8 is -H, and R9 is -Br. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridazinyl group, p is 0, m is 1, - is -CI, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R4 is -H, R8 is -H, and R9 is -Br. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridazinyl group, p is 0, m is 1, R, is -CH3, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R4 is -H, R8 is -H, and R9 is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ax{ is a thiazanyl group, p is 0, m is 1, - is -CH3 or -halo, x is 0, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to I the benzooxazolyl group, R4 is -H, R8 is -H, and R9 is -halo. In another embodiment, the

rbon atom to which the R3 group is attached has the R configuration. In another nbodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a thiazanyl group, p is 0, m is 1, R1 is -CH3, x is R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the snzooxazolyl group, R4 is -H, R8 is -H, and R9 is -CI. In another embodiment, the carbon ;om to which the R3 group is attached has the R configuration. In another embodiment, the arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a thiazanyl group, p is 0, m is 1, R} is -halo, x is , R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the enzooxazolyl group, R4 is -H, R8 is -H, and R? is -Br. In another embodiment, the carbon torn to which the R3 group is attached has the R configuration. In another embodiment, the arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a thiazanyl group, p is 0, m is 1, R1 is -CI, x is ), R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the enzooxazolyl group, R4 is -H, R8 is -H, and R9 is -Br. In another embodiment, the carbon itom to which the R3 group is attached has the R configuration. In another embodiment, the :arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a thiazanyl group, p is 0, m is 1, R1 is -CH3, x is 3, R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the benzooxazolyl group, R4 is -H, R8 is -H, and 1^ is -F. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, m is 1 and R3 is -(Cj-C4)alkyl and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- when x is 1 or the benzooxazolyl group when x is 0. In another embodiment, m is 1 and R3 is -(C1-C4)alkyl and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- when x is 1 or the benzooxazolyl group when x is 0 and the carbon to which the R3 group is attached is in the R configuration.
In another embodiment, m is 1 and R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- when x is 1 or the benzooxazolyl group when x is 0. In another embodiment, m is 1 and R3 is -CH3 and is attached to the

arbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- when x is 1 or the enzooxazolyl group when x is 0 and the carbon to which the R3 group is attached is in the R onfiguration.
In another embodiment, m is 1 and R3 is -(C1-C4)alkyl and is attached to the arbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- when x is 1 or the ►enzooxazolyl group when x is 0. In another embodiment, m is 1 and R3 is -(C1-C4)alkyl and s attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- when x is L or the benzooxazolyl group when x is 0 and the carbon to which the R3 group is attached is m the S configuration.
In another embodiment, m is 1 and R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- when x is 1 or the benzooxazolyl group when x is 0. In another embodiment, m is 1 and R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the -C(0)-N(R4)- when x is 1 or the benzooxazolyl group when x is 0 and the carbon to which the R3 group is attached is in the S configuration.
In another embodiment, m is 1 and R3 is -(CVQ^alkyl and is attached to the carbon atom adjacent to the nitR9gen attached to the pyrazinyl group, pyndazinyl group, or thiazanyl group. In another embodiment, m is 1 and R3 is -(CVC4)alkyl and is attached to the carbon atom adjacent to the nitR9gen attached to the pyrazinyl group, pyridazinyl group, or thiazanyl group and the carbon to which the R3 group is attached is in the R configuration.
In another embodiment, m is 1 and R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the pyrazinyl group, pyridazinyl group, or thiazanyl group. In another embodiment, m is 1 and R3 is -CH3 and is attached to the carbon atom adjacent to the nitR9gen attached to the pyrazinyl group, pyridazinyl group, or thiazanyl group and the carbon to which the R3 group is attached is in the R configuration.
In another embodiment, m is 1 and R3 is -(C1-C4)alkyl and is attached to the carbon atom adjacent to the nitR9gen attached to the pyrazinyl group, pyridazinyl group, or thiazanyl group. In another embodiment, m is 1 and R3 is -(C1-C4)alkyl and is attached to the carbon atom adjacent to the nitR9gen attached to the pyrazinyl group, pyridazinyl group, or thiazanyl group and the carbon to which the R3 group is attached is in the S configuration.

In another embodiment, m is 1 and R3 is -CH3 and is attached to the carbon om adjacent to the nitR9gen attached to the pyrazinyl group, pyridazinyl group, or thiazanyl oup. In another embodiment, m is 1 and R3 is -CH3 and is attached to the carbon atom ijacent to the nitR9gen attached to the pyrazinyl group, pyridazinyl group, or thiazanyl group id the carbon to which the R3 group is attached is in the S configuration.

and pharmaceutically acceptable salts thereof, where Axu Ar2, and R3, are defined above for the Benzoazolylpiperazine Compounds of formula (IVa).
In one embodiment, Arz is a pyridyl group.
In another embodiment, Ar, is a pyrimidinyl group.
In another embodiment, Ar2 is a benzothiazolyl group.
In another embodiment, Ar2 is a benzooxazolyl group.
In another embodiment, Ar2 is a benzoimidazolyl group.
In another embodiment, n or p is 0.
In another embodiment, n or p is 1.
In another embodiment, - is -CI.
In another embodiment, R, is -Br.
In another embodiment, R1 is -I.
In another embodiment, R1 is -F.
In another embodiment, R, is -(C^C^alkyl.
In another embodiment, R1 is -CH3.

In another embodiment, R1 is -N02.
In another embodiment, R1 is -CN.
In another embodiment, R1 is -OH.
In another embodiment, R1 is -OCH3.
In another embodiment, R1 is -NH2.
In another embodiment, R1 is -C(halo)3.
In another embodiment, R1 is -CH(halo)2.
In another embodiment, R1 is -CH2(halo).
In another embodiment, n and p are 1 and R2 is -halo, -CN, -OH, -0(Cr C6)alkyl, -N02, or -NH2.
In another embodiment, n and p are 1 and R2 is -(Cx-CXQ)a]kyl -(C2-C10)alkenyl, -(C2-C10)alkynyl, -(C3-C10)cycloalkyl, -(C8-C14)bicycloalkyl, -(C8-C14)tricycloalkyl, -(C5-C10)cycloalkenyl,-(C8-C14)bicycloalkenyl, -(C8-C14)tricycloalkenyl, -(3-to 7-membered)heteR9cycle, or -(7- to 10-membered)bicycloheteR9cycle, each of which is unsubstituted or substituted with one or more R5 groups.
In another embodiment, n and p are 1 and R2 is -phenyl, -naphthyl, -(CM)aryl, or -(5- to 10-membered)heteR9aryl, each of which is unsubstituted or substituted with one or more R6 groups;
In another embodiment, R3 is -H.
In another embodiment, R3 is -CH3.
In another embodiment, R8 and R9 are each independently -H, halo, -(Cj-C6)alkyl, -0(C1-C6)alkyl, -C(halo)3, -CH(halo)2, or -CH2(halo).
In another embodiment, at least one of R8 and R9 is -H.
In another embodiment, Axx is a pyridyl group, n is 0; R3 is -H; R1 is -F, -CI, -Br, or, -I;; Ar2 is a benzothiazolyl group; and R8 and 1^ are -H.
In another embodiment, A- is a pyridyl group, n is 0; R3 is -H; - is -F; Ar2 is a benzothiazolyl group; and R8 and R9 are -H.
In another embodiment, Axx is a pyridyl group, n is 0; R3 is -H; R1 is -F, -Cl( -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -H; and R? is -halo.
In another embodiment, Art is a pyridyl group, n is 0; R3 is -H; R1 is -F, Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -chloR9.

In another embodiment, Ar, is a pyridyl group, n is 0; K3 is -ti; K, is -r, JM2 is a benzothiazolyl group; R8 is -H; and R9 is -bR9mo.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -H; R1 is -F, Ar2 is i benzothiazolyl group; R8 is -H; and R9 is -fluoR9.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -H; R1 is -F, Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -iodo.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -H; - is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -halo; and R9 is -H.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -H; R1 is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -chloR9; and R? is -H.
In another embodiment, Axx is a pyridyl group, n is 0; R3 is -H; R, is -F, -CI, -Br, or -I; Ax2 is a benzothiazolyl group; R8 is -bR9mo; and R9 is -H.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -H; R1 is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R9is -fluoR9; and R9 is -H.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -H; R, is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -iodo; and R9 is -H.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -H; Rt is -F; Ar2 is a benzothiazolyl group; R8 is -halo, and R9 is -H.
In another embodiment, A^ is a pyridyl group, n is 0; R3 is -H; R, is -F; Ar2 is a benzothiazolyl group; R9is -chloR9, and R9 is -H.
In another embodiment, AR1 is a pyridyl group, n is 0; R3 is -H; R, is -F; Ar2 is a benzothiazolyl group; R8 is -bR9mo, and R9 is -H.
In another embodiment, Art is a pyridyl group, n is 0; R3 is -H; - is -F; Ar2 is a benzothiazolyl group; R8 is -fluoR9, and R9 is -H.
In another embodiment, AR1 is a pyridyl group, n is 0; R3 is -H; R, is -F; Ar2 is a benzothiazolyl group; R8 is -iodo, and R9 is -H.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -H; R, is -F, -CI, -Br, or -I;; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -CH3.
In another embodiment, AR1 is a pyridyl group, n is 0; R3 is -H; R1 is -F; Ar2 is a benzothiazolyl group; R8 is -H, and R9 is -CH3.

In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -H; R1 is -F, -Cl? -or -I; Ar2 is a benzothiazolyl group; R8 is -CH3; and R9» is -H.
In another embodiment, Art is a pyridyl group, n is 0; R3 is -H; Rt is -F; Ar2 is enzothiazolyl group; R8 is -CH3, and R9 is -H.
In another embodiment, AR1 is a pyridyl group, n is 0; R3 is -H; R1 is -F, -CI -, or -I; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -CF3.
In another embodiment, Axx is a pyridyl group, n is 0; R3 is -H; R1 is -F; Ar2 is enzothiazolyl group; R8 is -H; and R9is -CF3.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -H; R1 is -F, -CI, -:, or -I; Ar2 is a benzothiazolyl group; R8 is -CF3; and 1^ is -H,
In another embodiment, A^ is a pyridyl group, n is 0; R3 is -H; R1 is -F. Ar2 is benzothiazolyl group; R8 is -CF3; and R9 is ~H.
In another embodiment, Axx is a pyridyl group, n is 0; R3 is -H; - is -F, -CI -r5 or -I; Ar2 is a benzothiazolyl group; R8 is -H; and B^ is -OCH2CH3.
In another embodiment, Axx is a pyridyl group, n is 0; R3 is -H; R1 is -F; Ar2 is benzothiazolyl group; R8 is -H; and R9 is -OCH2CH3.
In another embodiment Axx is a pyridyl group, n is 0; R3 is -H; - is -F, -Clt -Jr, or -I; Ar2 is a benzothiazolyl group; R8 is -OCH2CH3; and R9 is -H.
In another embodiment, Axx Ar1 is a pyridyl group, n is 0; R3 is -H; R1 is -F.r2 is a benzothiazolyl group; R8 is -OCH2CH3; and R9 is -H.
In another embodiment, Axx is a pyridyl group, n is 0; R3 is -H; Rl is -F, -CI, -3r, or -I; Ar2 is a benzothiazolyl group; R8 is -tert-butyl; and R9 is -H.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -H; - is -F. Ar2 is a benzothiazolyl group; R8 is -tert-butyl; and R9 is -H.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -H; Rt is R, is -F, -CI -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -tert-butyl.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -H; Rt is - is -F. Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -te7t-butyl.
In another embodiment, Axx is a pyridyl group, n is 0; R3 is -CH3; - is -F5 -CI, -Br, or, -I; Ar2 is a benzothiazolyl group; and R8 and R9 are -H. In another embodiment, the

rbon atom to which the R3 group is attached has the R configuration, in anouier abodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -CH3; R1 is -F; Ar2 a benzothiazolyl group, and R9and R9are -H. In another embodiment, the carbon atom to hich the R3 group is attached has the R configuration. In another embodiment, the carbon torn to which the R3 group is attached has the S configuration.
In another embodiment, Art is a pyridyl group, n is 0; R3 is -CH3; R1 is ~F, -Q Br, or -I; Ar2 is a benzothiazolyl group; R8 is -H; and R9is -halo. In another embodiment, tie carbon atom to which the R3 group is attached has the R configuration. In another imbodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -CH3; Ri is -F, Ar2 s a benzothiazolyl group; R8 is -H; and R9is -chloR9. In another embodiment, the carbon itom to which the R3 group is attached has the R configuration. In another embodiment, the :arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group, n is 0; R3 is -CH3; R1 is -F, Ar2 is a benzothiazolyl group; R8 is -H; and R9is -bR9mo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyridyl group, n is 0; R3 is -CH3; R1 is -F, Ar2 is a benzothiazolyl group; R8 is -H; and R9is -fluoR9. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyridyl group, n is 0; R3 is -CH3; R1 is -F, Ar2 is a benzothiazolyl group; R8 is -H; and R9is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group, n is 0; R3 is -CH3; R1 is -F, -CI, «Br, or -I; Ar2 is a benzothiazolyl group; R8 is -halo; and R9is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another ' embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Ax} is a pyridyl group, n is 0; R3 is -CH3; R1 is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R9is -chloR9; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -CH3; R1 is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -bR9mo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -CH3; R1 is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -fluoR9; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -CH3; - is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -iodo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -CH3; R, is -F; Ar2 is a benzothiazolyl group; R8 is -halo, and R? is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -CH3; - is -F; Ar2 is a benzothiazolyl group; R8 is -chloR9, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyridyl group, n is 0; R3 is -CH3; R1 is -F; Ar2 is a benzothiazolyl group; R8 is -bR9mo, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -CH3; R, is -F; Ar2 i is a benzothiazolyl group; R8 is -fluoR9, and R9 is -H. In another embodiment, the carbon

atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -CH3; R, is -F; Ar2 is a benzothiazolyl group; R8 is -iodo, and R9 is -H, In another embodiment, the carbon atom o which the R3 group is attached has the R configuration. In another embodiment, the carbon itom to which the R3 group is attached has the S configuration.
In another embodiment, Ar} is a pyridyl group, n is 0; R3 is -CH3; R1 is -F, -CI, -Br, or -I;; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -CH3. In another embodiment, ;he carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, A- is a pyridyl group, n is 0; R3 is -CH3; - is -F; Ar2 is a benzothiazolyl group; R8 is -H, and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group, n is 0; R3 is -CH3; R1 is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, A- is a pyridyl group, n is 0; R3 is -CH3; R1 is -F; Ar2 is a benzothiazolyl group; R8 is -CH3, and 1^ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group, n is 0; R3 is -CH3; R1 is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group, n is 0; R3 is -CH3; - is -F. Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -CH3; R1 is -F, -CI, 3r, or -I; Ar2 is a benzothiazolyl group; R8 is -CF3; and R9 is -H. In another embodiment, the arbon atom to which the R3 group is attached has the R configuration. In another mbodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, A^ is a pyridyl group, n is 0; R3 is -CH3; R1 is -F; Ar2 5 a benzothiazolyl group; R8 is -CF3; and R9 is -H. In another embodiment, the carbon atom D which the R3 group is attached has the R configuration. In another embodiment, the carbon torn to which the R3 group is attached has the S configuration.
In another embodiment, Axy is a pyridyl group, n is 0; R3 is -CH3; R1 is ~F, -CI, Br, or -I; Ar2 is a benzothiazolyl group; R8 is -H; and R9is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In mother embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group, n is 0; R3 is -CH3; R1 is -F; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment Ar1 is a pyridyl group, n is 0; R3 is -CH3; R1 is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -OCH2CH3; and R, is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, ArI is a pyridyl group, n is 0; R3 is -CH3; R1 is -F; Ar2 is a benzothiazolyl group; R8 is -OCH2CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -CH3; R, is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -terf-butyl; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Axx is a pyridyl group, n is 0; R3 is -CH3; R, is -F; R8 is -terf-butyl; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -CH3; R1 is R} is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -ferr-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -CH3; R, is R, is -F; Ar2 is a benzothiazolyl group; R9is -H; and R9 is -fert-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F, -CI, -Br, or, -I;; Ar2 is a benzothiazolyl group; and R8 and R9 are -H.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F; Ar2 is a benzothiazolyl group, and R8 and R9 are -H.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F, -CI -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -halo.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F, Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -chloR9.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F, Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -bR9mo.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -H; R, is -F, Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -fluoR9.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -H; R, is -F, Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -iodo.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -halo; and Rp is -H.
In another embodiment, A- is a pyrimidinyl group, p is 0; R3 is -H; R, is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R3 is -chloR9; and 1^ is -H.

In another embodiment, Axx is a pyrimidinyl group, p is 0; R3 is -H; - is -F, -1, -Br, or -I; Ar2 is a benzothiazolyl group; Rs is -bR9mo; and R9 is -H.
In another embodiment, Axx is a pyrimidinyl group, p is 0; R3 is -H; R1 is -F, -!1, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -fluoR9; and R9 is -H.
In another embodiment, A- is a pyrimidinyl group, p is 0; R3 is -H; R1 is -F, -"1, -Br, or -I; Ar2 is a benzothiazolyl group; R9is -iodo; and R9 is -H.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -H; R1 is -F;r2 is a benzothiazolyl group; R8 is -halo, and R9 is -H.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -H; R1 is -F; \r2 is a benzothiazolyl group; R8 is -chloR9, and R9 is ~H.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -H; Ri is -F; \r2 is a benzothiazolyl group; R8 is -bR9mo, and R9 is -H.
In another embodiment, A- is a pyrimidinyl group, p is 0; R3 is -H; R, is -F; Ar2 is a benzothiazolyl group; R8 is -fluoR9, and R9 is -H.
In another embodiment, A^ is a pyrimidinyl group, p is 0; R3 is -H; - is -F; Ar2 is a benzothiazolyl group; R8 is -iodo, and R9 is -H.
In another embodiment, A- is a pyrimidinyl group, p is 0; R3 is -H; Ri is -F, -CI, -Br, or -I;; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -CH3.
In another embodiment, Axx is a pyrimidinyl group, p is 0; R3 is -H; R1 is -F; Ar2 is a benzothiazolyl group; R8 is -H, and R9 is -CH3.
In another embodiment, Axx is a pyrimidinyl group, p is 0; R3 is -H; R1 is -F, -CI -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -CH3; and R9 is -H.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R1 is -F; Ar2 is a benzothiazolyl group; R8 is -CH3J and R9 is -H.
In another embodiment, Ari is a pyrimidinyl group, p is 0; R3 is -H; R, is -F, -Clf «Br, or -I; Ar2 is a benzothiazolyl group; R8 is -H; and Rp is -CF3.
In another embodiment, Ari is a pyrimidinyl group, p is 0; R3 is -H; - is -F. Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -CF3.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; - is -F, - C\ -Br, or -I; Ar2 is a benzothiazolyl group; R9is -CF3; and R9 is -H.

In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F. Ar2 is a benzothiazolyl group; R8 is -CF3; and R9 is -H.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F, -CI -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -OCH2CH3.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F; Ar2 is a benzothiazolyl group; R8 is -H; and - is -OCH2CH3.
In another embodiment Ar, is a pyrimidinyl group, p is 0; R3 is -H; Ri is -F, -C\ -Br, or -I; Ar2 is a benzothiazolyl group; R9is -OCH2CH3; and R9 is -H.
In another embodiment, Ar, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F. Ar2 is a benzothiazolyl group; R8 is -OCH2CH3; and R9, is -H.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F, -CI -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -tert-butyl; and R9 is -H.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F. Ar2 is a benzothiazolyl group; R8 is -tert-butyl; and 11$ is -H.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is R, is -F, -CI -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -tert-butyl.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is R, is -F. Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -tert-butyl.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -CH3; R, is -F, -Cl( -Br, or, -I;; Ar2 is a benzothiazolyl group; and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -CH3; R, is -F. Ar2 is a benzothiazolyl group, and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -CH3; R, is -F, -CI -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In

lother'embodiment, the carbon atom to which the R3 group is attached has the S Dnfiguration.
In another embodiment, AR1 is a pyrimidinyl group, p is 0; R3 is -CH3; R1 is -F, JC2 is a benzothiazolyl group; R8 is -H; and R9 is -chloR9. In another embodiment, the carbon torn to which the R3 group is attached has the R configuration. In another embodiment, the arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -CH3; R1 is -F, \i2 is a benzothiazolyl group; R8 is -H; and R9 is -bR9mo. In another embodiment, the arbon atom to which the R3 group is attached has the R configuration. In another mbodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -CH3; Rt is -F,r2 is a benzothiazolyl group; R8 is -H; and R9 is -fluoR9. In another embodiment, the carbon itom to which the R3 group is attached has the R configuration. In another embodiment, the :arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; R3 is -CH3; Rt is -F, In another embodiment, AR1 is a pyrimidinyl group, p is 0; R3 is -CH3; R1 is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -halo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; R3 is -CH3; R1 is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -chloR9; andR9 is ~H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; R3 is -CH3; Rl is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -bR9mo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In

:ther embodiment, the carbon atom to which the R3 group is attached has the S afiguration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -CH3; - is -F, 1, -Br, or -I; Ar2 is a benzothiazoiyl group; R8 is -fluoR9; and R9 is -H. In another lbodiment, the carbon atom to which the R3 group is attached has the R configuration. In other embodiment, the carbon atom to which the R3 group is attached has the S nfiguration.
In another embodiment, A^ is a pyrimidinyl group, p is 0; R3 is -CH3; Ri is -F, "1, -Br, or -I; Ar2 is a benzothiazoiyl group; R8 is -iodo; and R9 is -H. In another nbodiment, the carbon atom to which the R3 group is attached has the R configuration. In lother embodiment, the carbon atom to which the R3 group is attached has the S mfiguration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; R3 is -CH3; - is -F; j2 is a benzothiazoiyl group; R8 is -halo, and R9 is -H. hi another embodiment, the carbon torn to which the R3 group is attached has the R configuration. In another embodiment, the arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -CH3; - is -F; \i2 is a benzothiazoiyl group; R8 is -chloR9, and R9is -H. In another embodiment, the carbon torn to which the R3 group is attached has the R configuration. In another embodiment, the arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, A^ is a pyrimidinyl group, p is 0; R3 is -CH3; - is -F;r2 is a benzothiazoiyl group; R8 is -bR9mo, and R9 is -H. In another embodiment, the carbon itom to which the R3 group is attached has the R configuration. In another embodiment, the ;arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -CH3; R, is -F; kr2 is a benzothiazoiyl group; R8 is -fluoR9, and R9 is -H. In another embodiment, the carbon itom to which the R3 group is attached has the R configuration. In another embodiment, the :arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyrimidinyl group, p is 0; R3 is -CH3; - is -F; Ar2 is a benzothiazoiyl group; R8 is -iodo, and R9 is -H. In another embodiment, the carbon

om to which the R3 group is attached has the R configuration. In another embodiment, the irbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyrimidinyl group, p is 0; R3 is -CH3; R1 is -F, Z\, -Br, or -I;; Ar2 is a benzothiazolyl group; R8 is -H; and R9, is -CH3. In another nbodiment, the carbon atom to which the R3 group is attached has the R configuration. In lother embodiment, the carbon atom to which the R3 group is attached has the S Dnfiguration.
In another embodiment, A^ is a pyrimidinyl group, p is 0; R3 is -CH3; - is -F; ii2 is a benzothiazolyl group; R9is -H, and R9 is -CH3. In another embodiment, the carbon torn to which the R3 group is attached has the R configuration. In another embodiment, the arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; R3 is -CH3; - is -F, CI, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -CH3; and R9is -H. In another smbodiment, the carbon atom to which the R3 group is attached has the R configuration. In mother embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AxY is a pyrimidinyl group, p is 0; R3 is -CH3; R, is -F; \r2 is a benzothiazolyl group; R8 is -CH3, and 1^ is -H. In another embodiment, the carbon itom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Art is a pyrimidinyl group, p is 0; R3 is -CH3; R1 is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -CH3; - is -F. Ar2 is a benzothiazolyl group; R8 is -H; and R9is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyrimidinyl group, p is 0; R3 is -CH3; R1 is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -CF3; and R9 is -H. In another

nbodiment, the carbon atom to which the R3 group is attached has the R configuration. In lother embodiment, the carbon atom to which the R3 group is attached has the S
^figuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; R3 is -CH3; - is -F; x2 is a benzothiazolyl group; R8 is -CF3; and R9 is -H. In another embodiment, the carbon torn to which the R3 group is attached has the R configuration. In another embodiment, the arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; R3 is -CH3; - is -F, CI, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -OCH2CH3. In another mbodiment, the carbon atom to which the R3 group is attached has the R configuration. In nother embodiment, the carbon atom to which the R3 group is attached has the S onfiguration.
hi another embodiment, AR1 is a pyrimidinyl group, p is 0; R3 is -CH3; R1 is -F; \r2 is a benzothiazolyl group; R8 is -H; and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration, ha another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment A- is a pyrimidinyl group, p is 0; R3 is -CH3; - is -F, ■CI, -Br, or -I; Ar2 is a benzothiazolyl group; R9is -OCH2CH3; and R9 is -H. In another smbodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ai{ is a pyrimidinyl group, p is 0; R3 is -CH3; R1 is -F; Ar2 is a benzothiazolyl group; R8 is -OCH2CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -CH3; R1 is -F, -CI, -Br, or -I; Ax2 is a benzothiazolyl group; R8 is -terr-butyl; and R? is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, A- is a pyrimidinyl group, p is 0; R3 is -CH3; R, is -F; is -terMnityl; and R9 is -H. In another embodiment, the carbon atom to which the R3 group attached has the R configuration. In another embodiment, the carbon atom to which the R3 oup is attached has the S configuration.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -CH3; R, is R, -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -te/t-butyl. In another abodhnent, the carbon atom to which the R3 group is attached has the R configuration. In iother embodiment, the carbon atom to which the R3 group is attached has the S nfiguration.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -CH3; R, is R, ; -F; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -tert-bxxtyl. In another embodiment, le carbon atom to which the R3 group is attached has the R configuration. In another mbodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -H; R, is -F, -CI, -5r, or, -I;; Ar2 is a benzoimidazolyl group; and R8 and R9 are -H.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -H; R, is -F; Ar2 is L benzoimidazolyl group, and R8 and R9 are -H.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -H; R, is -F, -Cl^ -3r, or -I; Ar2 is a benzoimidazolyl group; R8 is -H; and 1^ is -halo.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -H; R, is -F, Ar2 is i benzoimidazolyl group; R8 is -H; and is -chloR9.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -H; R, is -F, Ar2 is a. benzoimidazolyl group; R8 is -H; and R9 is -bR9mo.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -H; R, is -F, Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -fluoR9.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -H; R, is -F, Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -iodo.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -H; R, is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -halo; and R9 is -H.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -H; R, is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -chloR9; and R9 is -H.

In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -H; R, is -F, -CI, -ix9 or -I; Ar2 is a benzoimidazolyl group; R8 is -bR9mo; and R9 is -H.
In another embodiment, Ar j is a pyridyl group, n is 0; R3 is -H; R, is -F, -CI, -3r, or -I; Ar2 is a benzoimidazolyl group; R8 is -fluoR9; and R9 is -H.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -H; R, is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -iodo; and R9 is -H.
In another embodiment, Ar1 is apyridyl group, n is 0; R3 is -H; R, is -F; Ar2 is a benzoimidazolyl group; R8 is -halo, and R9 is -H.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -H; R, is -F; Ar2 is a benzoimidazolyl group; R9is -chloR9, and R9 is -H.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -H; R, is -F; Ar2 is a benzoimidazolyl group; R8 is -bR9mo, and R9 is -H.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -H; R, is -F; Ar2 is a benzoimidazolyl group; R8 is -fluoR9, and R9 is -H.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -H; R, is -F; Ar2 is a benzoimidazolyl group; R8 is -iodo, and R9 is -H.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -H; R, is -F, -CI, -Br, or -I;; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -CH3.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -H; R, is -F; Ar2 is a benzoimidazolyl group; R8 is -H, and R9 is -CH3.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -H; R1 is -F, -CI -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -CH3; and R9 is -H.
In another embodiment, Axx is a pyridyl group, n is 0; R3 is -H; R, is -F; Ar2 is a benzoimidazolyl group; R8 is -CH3, and R9 is -H.
In another embodiment, AR1 is a pyridyl group, n is 0; R3 is -H; R, is -F, -CI -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -CF3.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -H; R, is -F. Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -CF3.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -H; R, is -F, -Cl( -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -CF3; and R9 is -EL

In another embodiment, Art is a pyridyl group, n is 0; R3 is -H; - is -F. Ar2 is enzoimidazolyl group; R8 is -CF3; and R? is -H.
In another embodiment, Axx is a pyridyl group, n is 0; R3 is -H; Ri is -F, -CI -or -I; Ar2 is a benzoimidazolyl group; R9is -H; and R9 is -OCH2CH3.
In another embodiment, Axx is a pyridyl group, n is 0; R3 is -H; is -F; Ar2 is enzoimidazolyl group; R8 is -H; and R9 is -OCH2CH3.
In another embodiment Art is a pyridyl group, n is 0; R3 is -H; R1 is -F, -CI -, or -I; Ar2 is a benzoimidazolyl group; R8 is -OCH2CH3; and R9 is -H.
In another embodiment, Ar, AR1 is a pyridyl group, n is 0; R3 is -H; R1 is -F. r2 is a benzoimidazolyl group; R8 is -OCH2CH3; and R? is -H.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -H; Rt is -F, -Cl^ -r, or -I; Ar2 is a benzoimidazolyl group; R8 is -tert-butyl; and 11$ is -H.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -H; R1 is -F. Ar2 is benzoimidazolyl group; R8 is -terf-butyl; and R9 is -H.
In another embodiment, Art is a pyridyl group, n is 0; R3 is -H; R1 is R1 is -F, -1 -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -tert-butyl.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -H; R1 is - is -F. \x2 is a benzoimidazolyl group; R8 is -H; and R9 is -tert-butyl.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -CH3; - is -F, -CI Br, or, -I;; Ar2 is a benzoimidazolyl group; and R8 and are -H. In another embodiment, he carbon atom to which the R3 group is attached has the R configuration. In another ;mbodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -CH3; R1 is -F. Ar2 s a benzoimidazolyl group, and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -CH3; R1 is -F, -CI -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -H; and 1^ is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -CH3; R1 is -F, Ar2 3 a benzoimidazolyl group; R8 is -H; and R9, is -chloR9. In another embodiment, the carbon torn to which the R3 group is attached has the R configuration. In another embodiment, the arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -CH3; Rt is -F, Ar2 s a benzoimidazolyl group; R8 is -H; and R9 is -bR9mo. In another embodiment, the carbon itom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -CH3; - is -F, Ar2 Is a benzoimidazolyl group; R8 is -H; and R9 is -fluoR9. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group, n is 0; R3 is -CH3; - is -F, Ar2 is a benzoimidazolyl group; R9is -H; and R9 is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyridyl group, n is 0; R3 is -CH3; R, is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -halo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Art is a pyridyl group, n is 0; R3 is -CH3; - is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -chloR9; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ari is a pyridyl group, n is 0; R3 is -CH3; R, is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -bR9mo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Ari is a pyridyl group, n is 0; R3 is -CH3; - is -F, -CI, 3r, or -I; Ar2 is a benzoimidazolyl group; R8 is -fluoR9; and R9 is -H. In another mbodiment, the carbon atom to which the R3 group is attached has the R configuration. In nother embodiment, the carbon atom to which the R3 group is attached has the S onfiguration.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -CH3; R1 is -F, -CI, Br, or -I; Ar2 is a benzoimidazolyl group; R9is -iodo; and R9 is -H. In another embodiment, he carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, A- is a pyridyl group, n is 0; R3 is -CH3; - is -F; Ar2 is a benzoimidazolyl group; R8 is -halo, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, A- is a pyridyl group, n is 0; R3 is -CH3; R1 is -F; Ar2 is a benzoimidazolyl group; R8 is -chloR9, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axl is a pyridyl group, n is 0; R3 is -CH3; R] is -F; Ar2 is a benzoimidazolyl group; R9is -bR9mo, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyridyl group, n is 0; R3 is -CH3; R, is -F; Ar2 is a benzoimidazolyl group; Rs is -fluoR9, and R9is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, A- is a pyridyl group, n is 0; R3 is -CH3; R1 is -F; Ar2 is a benzoimidazolyl group; R8 is -iodo, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -CH3; R1 is -F, -CI, -Br, or -I;; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -CH3. In another

embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -CH3; - is -F; Ar2 is a benzoimidazolyl group; R8 is -H, and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyridyl group, n is 0; R3 is -CH3; R1 is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -CH3; - is -F; Ar2 is a benzoimidazolyl group; R8 is -CH3, and 0$ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the i carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -CH3; R, is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyridyl group, n is 0; R3 is -CH3; - is -F. Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -CF3, In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ax} is a pyridyl group, n is 0; R3 is -CH3; R1 is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -CF3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -CH3; Rl is -F; Ar2 is a benzoimidazolyl group; R8 is -CF3; and R9 is -H. In another embodiment, the carbon i atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -CH3; R, is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -CH3; R, is -F; Ar2 is a benzoimidazolyl group; R9is -H; and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment Ar, is a pyridyl group, n is 0; R3 is -CH3; - is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -OCH2CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -CH3; R, is -F; Ar2 is a benzoimidazolyl group; R8 is -OCH2CH3; and R§ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -CH3; R, is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -tert-butyl; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -CH3; R, is -F; R8 is -tert-butyl; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -CH3; R, is R, is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -tert-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In

another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -CH3; R, is R, is -F; Ar2 is a benzoimidazolyl group; R9is -H; and R9 is -tert-butyL In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F, -CI, -Br, or, -I;; Ar2 is a benzoimidazolyl group; and R8 and R9 are -H.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F; Ar2 is a benzoimidazolyl group, and R9and R9 are -H.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F, -CI -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -halo.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -H; R, is -F, Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -chloR9.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F, Ar2 is a benzoimidazolyl group; R8 is -H; and R, is -bR9mo.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F, Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -fluoR9.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F, Ar2 is a benzoimidazolyl group; R8 is -H; and R? is -iodo.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -halo; and R9 is -H.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -chloR9; and R9 is -H.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -bR9mo; and R9 is -H.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R9is -fluoR9; and 1^ is -H.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R9is -iodo; and R9 is -H.

In another embodiment, Ar: is a pyrimidinyl group, p is 0; R3 is -H; R1 is -F; r2 is a benzoimidazolyl group; R8 is -halo, and R9 is -H.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -H; - is -F; r2 is a benzoimidazolyl group; R8 is -chloR9, and R9 is -H.
In another embodiment, AR1 is a pyrimidinyl group, p is 0; R3 is -H; R1 is -F; r2 is a benzoimidazolyl group; R8 is -bR9mo, and R9 is -H.
In another embodiment, A- is a pyrimidinyl group, p is 0; R3 is -H; R1 is -F; r2 is a benzoimidazolyl group; R8 is -fluoR9, and R9 is -H.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -H; Rl is -F; ii2 is a benzoimidazolyl group; R8 is -iodo, and R9is -H.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -H; R1 is -F, -"1, -Br, or -I;; Ar2 is a benzoimidazolyl group; R8 is -H; and R9is -CH3.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -H; Ri is -F; Vr2 is a benzoimidazolyl group; R8 is -H, and R9 is -CH3.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F, -Z\ -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -CH3; and R9 is -H.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -H; R1 is -F; \r2 is a benzoimidazolyl group; R8 is -CH3, and R9 is -H.
In another embodiment, AR1 is a pyrimidinyl group, p is 0; R3 is -H; R1 is -F, -C\ -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -CF3.
In another embodiment, A- is a pyrimidinyl group, p is 0; R3 is -H; R1 is -F. Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -CF3,
In another embodiment, A- is a pyrimidinyl group, p is 0; R3 is -H; R1 is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -CF3; and R9 is -EL
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R1 is -F. Ar2 is a benzoimidazolyl group; R8 is -CF3; and R9 is -H.
In another embodiment, A- is a pyrimidinyl group, p is 0; R3 is -H; R, is -F, -Clt -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -OCH2CH3.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R1 is -F; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -OCH2CH3.

In another embodiment Ar, is a pyrimidinyl group, p is 0; R3 is -H; - is -F, -:i -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -OCH2CH3; and R9 is -H.
In another embodiment, Ar, Ar1 is a pyrimidinyl group, p is 0; R3 is -H; R, is -'. Ar2 is a benzoimidazolyl group; R8 is -OCH2CH3; and R9is -H.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F, -l\ -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -rerf-butyl; and R9 is -H.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F.r2 is a benzoimidazolyl group; R8 is -tert-butyl; and R9 is -H.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is R, is F, -CI -Br, or -I; Ar2 is a benzoimidazolyl group; Rs is -H; and is -tert-butyl.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is R, is ■F. Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -terf-butyl.
La another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -CH3; R, is -F, -CI -Br, or, -I;; Ar2 is a benzoimidazolyl group; and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -CH3; R, is -F. Ar2 is a benzoimidazolyl group, and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -CH3; R, is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -H; and 1^ is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -CH3; R, is -F, Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -chloR9. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is ~CH3; R1 is -F, Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -bR9mo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, A- is a pyrimidinyl group, p is 0; R3 is -CH3; R, is -F, Ar2 is a benzoimidazolyl group; R9is -H; and R9 is -fluoR9. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -CH3; R1 is -F, Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -iodo. La another embodiment, the carbon atom to which the R3 group is attached has the R configuration. La another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
La another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -CH3; R, is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -halo; and R9is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. La another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -CH3; R1 is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -chloR9; and R9 is -H. La another embodiment, the carbon atom to which the R3 group is attached has the R configuration. La another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -CH3; R, is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -bR9mo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom tp which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -CH3; R, is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -fluoR9; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In

another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Arl is a pyrimidinyl group, p is 0; R3 is -CH3; R1 is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -iodo; and R9is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, A- is a pyrimidinyl group, p is 0; R3 is -CH3; R} is -F; Ar2 is a benzoimidazolyl group; R8 is -halo, and R9is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -CH3; R1 is -F; Ar2 is a benzoimidazolyl group; R8 is -chloR9, and R9is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Art is a pyrimidinyl group, p is 0; R3 is -CH3; R1 is -F; Ar2 is a benzoimidazolyl group; R8 is -bR9mo, and R9is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Art is a pyrimidinyl group, p is 0; R3 is -CH3; R1 is -F; Ar2 is a benzoimidazolyl group; R8 is -fluoR9, and R9is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -CH3; R} is -F; Ar2 is a benzoimidazolyl group; R8 is -iodo, and R9is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ai} is a pyrimidinyl group, p is 0; R3 is -CH3; R1 is -F, -CI, -Br, or -I;; Ar2 is a benzoimidazolyl group; R8 is -H; and R9is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In

another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -CH3; R1 is -F; Ar2 is a benzoimidazolyl group; R8 is -H, and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration*
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -CH3; Rt is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R9is -CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has file S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -CH3; Rt is -F; Ar2 is a benzoimidazolyl group; R9is -CH3, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -CH3; - is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ai} is a pyrimidinyl group, p is 0; R3 is -CH3; - is -F. Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, A- is a pyrimidinyl group, p is 0; R3 is -CH3; R1 is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -CF3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -CH3; is -F; Ar2 is a benzoimidazolyl group; R8 is -CF3; and R9is -H. In another embodiment, the carbon

torn to which the R3 group is attached has the R configuration. In another embodiment, the arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -CH3; R1 is -F, CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -H; and R9is -OCH2CH3. hi another mbodiment, the carbon atom to which the R3 group is attached has the R configuration. In nother embodiment, the carbon atom to which the R3 group is attached has the S ;onfiguration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -CH3; - is -F; \x2 is a benzoimidazolyl group; R9is -H; and R9is -OCH2CH3. In another embodiment, the :arbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment Ax} is a pyrimidinyl group, p is 0; R3 is -CH3; R1 is -F, -CI, «Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -OCH2CH3; and R9is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR9 is a pyrimidinyl group, p is 0; R3 is -CH3; R, is -F; Ar2 is a benzoimidazolyl group; R8 is -OCH2CH3; and R9is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -CH3; R1 is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -tert-butyl; and R9is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration, hi another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyrimidinyl group, p is 0; R3 is -CH3; - is -F; R8 is -ter*-butyl; and R9is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -CH3; R| is -is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -H; and R9is -tert-butyl. In

other embodiment, the carbon atom to which the R3 group is attached has the Rfiguration. In another embodiment, the carbon atom to which the R3 group is attached has e S configuration.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -CH3; - is R1 -F; Ar2 is a benzoimidazolyl group; R8 is -H; and R9is -fert-butyl. In another embodiment, Le carbon atom to which the R3 group is attached has the R configuration. In another cnbodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -H; R1 is -F, -CI, -ir, or, -I;; Ar2 is a benzooxazolyl group; and Rs and R9 are -H.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -H; R1 is -F; Ar2 is . benzooxazolyl group, and R8 and R9are -H.
In another embodiment, A- is a pyridyl group, n is 0; R3 is -H; Rt is -F, -CI -5r, or -I; Ar2 is a benzooxazolyl group; R9is -H; and R9is -halo.
In another embodiment, AiY is a pyridyl group, n is 0; R3 is -H; R1 is -F, Ar2 is i benzooxazolyl group; R8 is -H; and R9 is -chloR9.
In another embodiment, Ax{ is a pyridyl group, n is 0; R3 is -H; R, is -F, Ar2 is a benzooxazolyl group; R8 is -H; and R9is -bR9mo.
In another embodiment, AR1 is a pyridyl group, n is 0; R3 is -H; R1 is -F, Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -fluoR9.
In another embodiment, AR1 is a pyridyl group, n is 0; R3 is -H; - is -F, Ar2 is a benzooxazolyl group; R8 is -H; and R9is -iodo.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -H; - is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R9is -halo; and R9is -H.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -H; - is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -chloR9; and R9is -H.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -H; R, is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -bR9mo; and R9is -H.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -H; Rt is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -fluoR9; and R9is -H.
In another embodiment, Art is a pyridyl group, n is 0; R3 is -H; - is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -iodo; and R9 is -H.

hi another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -H; R1 is -F; Ar2 is benzooxazolyl group; R8 is -halo, and R9 is -EL
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -H; Ri is -F; Ar2 is benzooxazolyl group; R8 is -chloR9, and R9is -H.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -H; R1 is -F; Ar2 is benzooxazolyl group; R8 is -bR9mo, and R9is -H.
In another embodiment, A- is a pyridyl group, n is 0; R3 is -H; R1 is -F; Ar2 is . benzooxazolyl group; R9is -fluoR9, and R9is -H.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -H; - is -F; Ar2 is i benzooxazolyl group; R8 is -iodo, and R9is -H.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -H; R, is -F, -CI, -Br, or -I;; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -CH3.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -H; R, is -F; Ar2 is a benzooxazolyl group; R8 is -H, and R9 is -CH3.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -H; R{ is -F, -Cl^ -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -CH3; and R9 is -H.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -H; - is -F; Ar2 is a benzooxazolyl group; R8 is -CH3, and R9is -EL
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -H; R1 is -F, -C\ -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -H; and'R9is -CF3.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -H; R1 is -F. Ar2 is a benzooxazolyl group; R8 is -H; and R9is -CF3.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -H; R1 is -F, -C\ -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -CF3; and R9is -H.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -H; Rt is -F. Ar2 is a benzooxazolyl group; R8 is -CF3; and R9is -H.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -H; R{ is -F, -Cl^ -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -H; and R9is -OCH2CH3.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -H; R, is -F; Ar2 is a benzooxazolyl group; R8 is -H; and R9is -OCH2CH3.

hi another embodiment Ax, is a pyridyl group, n is 0; R3 is -H; - is -F, -CI -5r, or -I; Ar2 is a benzooxazolyl group; R8 is -OCH2CH3; and R9is -H.
In another embodiment, A- AR1 is a pyridyl group, n is 0; R3 is -H; Rt is -F.r2 is a benzooxazolyl group; R8 is -OCH2CH3; and R9is -H.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -H; Rt is -F, -CI -3r, or -I; Ar2 is a benzooxazolyl group; R8 is -tert-butyl; and R9is -H.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -H; R1 is -F. Ar2 is i benzooxazolyl group; R8 is -tert-butyl; and R9is -H.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -H; R, is - is -F, -CI -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -H; and R9is -tert-butyl.
In another embodiment, Ars is a pyridyl group, n is 0; R3 is -H; R1 is - is -F. Ar2 is a benzooxazolyl group; R8 is -H; and R9is -teit-butyl.
In another embodiment, A- is a pyridyl group, n is 0; R3 is -CH3; R5 is -F, -Clt -Br, or, -I;; Ar2 is a benzooxazolyl group; and R8 and R9are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. Li another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -CH3; - is -F. Ar2 is a benzooxazolyl group, and R8 and R9are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyridyl group, n is 0; R3 is -CH3; R, is -F, -CI -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -H; and R9is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyridyl group, n is 0; R3 is -CH3; R1 is -F, Ar2 is a benzooxazolyl group; R8 is -H; and R9is -chloR9. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -CH3; R1 is -F, Ar2 is a benzooxazolyl group; R8 is -H; and R9is -bR9mo. In another embodiment, the carbon

itom to which the R3 group is attached has the R configuration. In another embodiment, the :arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -CH3; - is -F, Ar2 s a benzooxazolyl group; R8 is -H; and R9 is -fluoR9. In another embodiment, the carbon itom to which the R3 group is attached has the R configuration. In another embodiment, the :arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ai{ is a pyridyl group, n is 0; R3 is -CH3; R1 is -F, Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ai} is a pyridyl group, n is 0; R3 is -CH3; - is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -halo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -CH3; R1 is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -chloR9; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -CH3; R1 is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -bR9mo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -CH3; R1 is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -fluoR9; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyridyl group, n is 0; R3 is -CH3; - is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -iodo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Ax} is a pyridyl group, n is 0; R3 is -CH3; - is -F; Ar2 a benzooxazolyl group; R8 is -halo, and R9 is -H. In another embodiment, the carbon atom which the R3 group is attached has the R configuration. In another embodiment, the carbon Lorn to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -CH3; R, is -F; Ar2 a benzooxazolyl group; R8 is -chloR9, and R9 is -H. In another embodiment, the carbon torn to which the R3 group is attached has the R configuration. In another embodiment, the arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ax{ is a pyridyl group, n is 0; R3 is -CH3; R, is -F; Ar2 s a benzooxazolyl group; R8 is -bR9mo, and R9 is -H. In another embodiment, the carbon itom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -CH3; R, is -F; Ar2 s a benzooxazolyl group; R8 is -fluoR9, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyridyl group, n is 0; R3 is -CH3; - is -F; Ar2 is a benzooxazolyl group; R8 is -iodo, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, A- is a pyridyl group, n is 0; R3 is -CH3; R1 is -F, -CI, -Br, or -I;; Ar2 is a benzooxazolyl group; R9is -H; and R9is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar: is a pyridyl group, n is 0; R3 is -CH3; R1 is -F; Ar2 is a benzooxazolyl group; R8 is -H, and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. La another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyridyl group, n is 0; R3 is -CH3; Rr is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -CH3; and R9 is -H. In another embodiment, the

arbon atom to which the R3 group is attached has the R configuration. In another mbodiment, the carbon atom to which the R3 group is attached has the S configuration.
hi another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -CH3; - is -F; Ar2 s a benzooxazolyl group; R8 is -CH3, and R9, is -H. In another embodiment, the carbon atom o which the R3 group is attached has the R configuration. In another embodiment, the carbon itom to which the R3 group is attached has the S configuration.
In another embodiment, A- is a pyridyl group, n is 0; R3 is -CH3; R1 is -F, -CI, Br, or -I; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -CF3. In another embodiment, he carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -CH3; R1 is -F. Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -CH3; R, is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -CF3; and R9, is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyridyl group, n is 0; R3 is -CH3; R, is -F; Ar2 is a benzooxazolyl group; R8 is -CF3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -CH3; R1 is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -H; and 1^ is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -CH3; R1 is -F; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment Ar, is a pyridyl group, n is 0; R3 is -CH3; R, is -F, -CI, ', or -I; Ar2 is a benzooxazolyl group; R8 is -OCH2CH3; and R9 is -H. In another bodiment, the carbon atom to which the R3 group is attached has the R configuration. In )ther embodiment, the carbon atom to which the R3 group is attached has the S afiguration.
In another embodiment, Ar j is a pyridyl group, n is 0; R3 is -CH3; R, is -F; Ar2 a benzooxazolyl group; R9is -OCH2CH3; and R9 is -H. In another embodiment, the carbon sm to which the R3 group is attached has the R configuration. In another embodiment, the rbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -CH3; R, is -F, -CI, Jr, or -I; Ar2 is a benzooxazolyl group; R8 is -tert-butyl; and R9 is -H. In another nbodiment, the carbon atom to which the R3 group is attached has the R configuration. In lother embodiment, the carbon atom to which the R3 group is attached has the S Dnfiguration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -CH3; R, is -F; R8 -tert-butyl; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is ttached has the R configuration. In another embodiment, the carbon atom to which the R3 jR9up is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -CH3; R, is R, is -7, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -terf-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In mother embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R3 is -CH3; R, is R, is -F; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -terf-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F, -CI, -Br, or, -I;; Ar2 is a benzooxazolyl group; and R8 and R? are -H.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F; Ar2 is a benzooxazolyl group, and R8 and R9 are -H,

In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F, -2\ -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -halo.
In another embodiment, A- is a pyrimidinyl group, p is 0; R3 is -H; R, is -F, \r2 is a benzooxazolyl group; R8 is -H; and R9is -chloR9.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F, kr2 is a benzooxazolyl group; R8 is -H; and R9 is -bR9mo.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R1 is -F, Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -fluoR9.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F, Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -iodo.
In another embodiment, A- is a pyrimidinyl group, p is 0; R3 is -H; R1 is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -halo; and R9is -H.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -chloR9; and R9is -H.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -bR9mo; and R9is -H.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -fluoR9; and R9 is -H.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -iodo; and R9is -H.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F; Ar2 is a benzooxazolyl group; R9is -halo, and R9is -H.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F; Ar2 is a benzooxazolyl group; R9is -chloR9, and R9is -H.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F; Ar2 is a benzooxazolyl group; R9is -bR9mo, and R9is -H.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F; Ar2 is a benzooxazolyl group; R8 is -fluoR9, and R9 is -H.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F; Ar2 is a benzooxazolyl group; R8 is -iodo, and R9is -H.

In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -H; R, is -F, -I, -Br, or -I;; Ar2 is a benzooxazolyl group; Rs is -H; and R9 is -CH3.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F; r2 is a benzooxazolyl group; R9is -H, and R9is -CH3.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F, -1 -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -CH3; and R9is -H.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F; J:2 is a benzooxazolyl group; R8 is -CH3, and R9is -H.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F, -'1 -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -H; and R9is -CF3.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F.r2 is a benzooxazolyl group; R8 is -H; and R9is -CF3.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F, -Z\ »Br, or -I; Ar2 is a benzooxazolyl group; R8 is -CF3; and R9is -H.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F. \r2 is a benzooxazolyl group; R8 is -CF3; and R9is -H.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F, -Z\ -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -H; and R§ is -OCH2CH3.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F; Ar2 is a benzooxazolyl group; R8 is -H; and R9is -OCH2CH3.
In another embodiment Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F, -CI -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -OCH2CH3; and R9is -H.
In another embodiment, Ar, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F; Ar2 is a benzooxazolyl group; R8 is -OCH2CH3; and R9is -H.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F, -CI -Br, or -I; Ar2 is a benzooxazolyl group; Rs is -tert-butyl; and R9is -H.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is -F. Ar2 is a benzooxazolyl group; R8 is -tert-butyl; and R9is -H.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -H; R, is R, is -F, -Cl( «Br, or -I; Ar2 is a benzooxazolyl group; R8 is -H; and R9is -tert-butyl.

In another embodiment, Ai] is a pyrimidinyl group, p is 0; R3 is -H; R, is - is -F. Ar2 is a benzooxazolyl group; R8 is -H; and R9is -tert-butyl.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -CH3; is -F, -Clt -Br, or, -I; Ar2 is a benzooxazolyl group; and R8 and R9are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -CH3; - is -F. Ar2 is a benzooxazolyl group, and R8 and R9are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -CH3; R2 is -F, -C\ -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -H; and R9is -halo, hi another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyrimidinyl group, p is 0; R3 is -CH3; R{ is ~F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R9is -H; and R9is -chloR9. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -CH3; - is -F, -Q -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -H; and R9is -bR9mo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -CH3; R2 is -F, -CI -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -H; and R9is -fluoR9. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -CH3; - is -F, -CI -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -H; and R9is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -CH3; R1 is -F, Ar2 is a benzooxazolyl group; R8 is -H; and R9is -chloR9. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ail is a pyrimidinyl group, p is 0; R3 is -CH3; R1 is -F, Ar2 is a benzooxazolyl group; R8 is -H; and R9is -bR9mo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -CH3; R1 is -F, Ar2 is a benzooxazolyl group; R8 is -H; and R9is -fluoR9. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -CH3; R1 is -F, Ar2 is a benzooxazolyl group; R8 is -H; and R9is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -CH3; R, is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R9is -halo; and R9is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -CH3; is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -chloR9; and R9is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -CH3; R1 is -F, L, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -bR9mo; and R9 is -H. In another ibodiment, the carbon atom to which the R3 group is attached has the R configuration. In other embodiment, the carbon atom to which the R3 group is attached has the S nfiguration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -CH3; - is -F, X -Br, or «I; Ar2 is a benzooxazolyl group; R9is -fluoR9; and R9 is -H. In another nbodiment, the carbon atom to which the R3 group is attached has the R configuration. In lother embodiment, the carbon atom to which the R3 group is attached has the Sfiguration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -CH3; - is -F, 31, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -iodo; and R9 is -H. In another mbodiment, the carbon atom to which the R3 group is attached has the R configuration. In nother embodiment, the carbon atom to which the R3 group is attached has the S ;onfiguration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -CH3; R1 is -F; \r2 is a benzooxazolyl group; R8 is -halo, and R9 is -H. In another embodiment, the carbon itom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyrimidinyl group, p is 0; R3 is -CH3; - is -F; Ar2 is a benzooxazolyl group; R8 is -chloR9, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -CH3; R1 is -F; Ar2 is a benzooxazolyl group; R8 is -bR9mo, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ax{ is a pyrimidinyl group, p is 0; R3 is -CH3; Rt is -F; Ar2 is a benzooxazolyl group; R8 is -fluoR9, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -CH3; - is -F; Ar2 is a benzooxazolyl group; R9is -iodo, and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, A- is a pyrimidinyl group, p is 0; R3 is -CH3; R, is -F, -CI, -Br, or -I;; Ar2 is a benzooxazolyl group; Rs is -H; and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyrimidinyl group, p is 0; R3 is -CH3; - is -F; Ar2 is a benzooxazolyl group; R9is -H, and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ax} is a pyrimidinyl group, p is 0; R3 is -CH3; Ri is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -CH3; and R9, is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -CH3; R1 is -F; Ar2 is a benzooxazolyl group; R9is -CH3, and R9is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
hi another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -CH3; R1 is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -CH3; Ri is -F. Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -CH3; R1 is -F, •1, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -CF3; and R9 is -H. In another nbodiment, the carbon atom to which the R3 group is attached has the R configuration. In lother embodiment, the carbon atom to which the R3 group is attached has the S snfiguration.
hi another embodiment, Art is a pyrimidinyl group, p is 0; R3 is -CH3; R1 is -F; LT2 is a benzooxazolyl group; R8 is -CF3; and R9 is -H. In another embodiment, the carbon torn to which the R3 group is attached has the R configuration. In another embodiment, the arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -CH3; R, is -F, CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -OCH2CH3. In another mbodiment, the carbon atom to which the R3 group is attached has the R configuration. In mother embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyrimidinyl group, p is 0; R3 is -CH3; R1 is -F;r2 is a benzooxazolyl group; R8 is -H; and R9 is -OCH2CH3. In another embodiment, the :arbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment ArL is a pyrimidinyl group, p is 0; R3 is -CH3; - is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R9is -OCH2CH3; and R9 is -H. hi another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is »CH3; R1 is -F; Ar2 is a benzooxazolyl group; R8 is -OCH2CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Art is a pyrimidinyl group, p is 0; R3 is -CH3; R1 is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -tert-butyl; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In

LOther embodiment, the carbon atom to which the R3 group is attached has the S mfiguration.
In another embodiment, Axl is a pyrimidinyl group, p is 0; R3 is -CH3; - is -F; B is -/erf-butyl; and R9 is -H, In another embodiment, the carbon atom to which the R3 group attached has the R configuration. In another embodiment, the carbon atom to which the R3 R9up is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -CH3; RY is R1 \ -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -H; and R9, is -/erf-butyl. In another mbodiment, the carbon atom to which the R3 group is attached has the R configuration. In aother embodiment, the carbon atom to which the R3 group is attached has the S onfiguration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R3 is -CH3; R1 is R, 5 -F; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -tert-butyl. In another embodiment, he carbon atom to which the R3 group is attached has the R configuration. In another mbodiment, the carbon atom to which the R3 group is attached has the S configuration.

and pharmaceutical!/ acceptable salts thereof, where Ar„ Ar2, A, R3 and x are defined above for the Benzoazolylpiperazine Compounds of formula (IVb).
In one embodiment, Ar1 is a pyridyl group.
In another embodiment, Ax} is a pyrimidinyl group.

In another embodiment, n or p is 0.
In another embodiment, n or p is 1.
In another embodiment, x is 0.
In another embodiment, x is 1.
In another embodiment, R, is -F.
In another embodiment, R, is -CI.
In another embodiment, R1 is -Br.
In another embodiment, R{ is -L
In another embodiment R1 is -(C1-C6)alkyl.
In another embodiment, - is -CH3.
In another embodiment, R, is -N02.
In another embodiment, R, is -CN.
In another embodiment, R1 is -OH.
In another embodiment, R1 is -OCH3.
In another embodiment, - is -NH2.
In another embodiment, R1 is -C(halo)3.
In another embodiment, - is -CH(halo)2.
In another embodiment, - is -CH2(halo).
In another embodiment, n and p are 1 and R2 is -halo, -CN, -OH, -0(C,-C6)alkyl, -N02, or -NH2.
In another embodiment, n and p are 1 and R2 is -C1-C10alkyl, -(C2-C10)alkenyl, -(CrC!0)alkynyl, -(C3-C10)cycloalkyl, -(C8-C14)bicycloalkyl, -(C8-Cl4)tricycloalkyl, -(C5-C10)cycloalkenyl,-(C8-C14)bicycloalkenyl, -(C8-C14)tricycloalkenyl, -(3-to 7-membered)heteR9cycle, or -(7- to 10-membered)bicycloheteR9cycle, each of which is unsubstituted or substituted with one or more R5 groups.
In another embodiment, n and p are 1 and R2 is -phenyl, -naphthyl, -(C14)aryl, or -(5- to 10-membered)heteR9aryl, each of which is unsubstituted or substituted with one or more R6 groups;
In another embodiment, x is 1 and A is -C(0)N(R4)-.
In another embodiment, x is 1, A is -C(0)N(R4)-, and R4 is -H.
In another embodiment, x is 1, A is -C(0)N(R4)-, and R4 is -CH3.

In another embodiment, x is 1 and A is -C(S)N(R4)-.
In another embodiment, x is 1, A is -C(S)N(R4)-, and R4 is -H.
In another embodiment, x is 1, A is -C(S)N(R4)-, and R4 is -CH3.
In another embodiment, Ar2 is a benzothiazolyl group.
In another embodiment, Ar2 is abenzoimidazolyl group.
hi another embodiment, Ar2 is a benzooxazolyl group.
In another embodiment, R8 and R9 are each independently -H, halo, -(Cr6)alkyl, -0(C1-C6)alkyl, -C(halo)3, -CH(halo)2, or -CH2(halo).
In another embodiment, at least one of R8 or R9 is -H.
In another embodiment, Ar1 is a pyridyl group, n is 0; - is -F, -CI, -Br, or -I; R4 is -H; Ar2 is a benzothiazolyl group; and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyridyl group, n is 0; is -F. R4 is -H; Ar2 is a benzothiazolyl group and R8 and 1^ are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, A- is a pyridyl group, n is 0; R, is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -H; and B^ is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ail is a pyridyl group, n is 0; Rt is -F, -CI -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -chloR9. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R, is -F, -CI -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -H; and 11$ is -bR9mo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, A- is a pyridyl group, n is 0; - is -F, -CI -Br, or -I; Ar2 is a benzothiazolyl group; Rs is -H; and R9, is -fluoR9. In another embodiment, the carbon

atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R1 is -F, -Cl( -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; - is -F; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, A- is a pyridyl group, n is 0; - is -F; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -chloR9. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R2 is -F; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -bR9mo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ax} is a pyridyl group, n is 0; R, is -F; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -fluoR9. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R, is -F; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R1 is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -halo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Ar, is a pyridyl group, n is 0; RY is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -chloR9; and R9 is «H.
In another embodiment, Ar1 is a pyridyl group, n is 0; - is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -bR9mo; and R9 is -H. In another embodiment the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R1 is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R9is -fluoR9; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; - is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -iodo; and R9is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; - is -F; Ar2 is a benzothiazolyl group; R9is -halo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; K} is -F; Ar2 is a benzothiazolyl group; R8 is -chloR9; and R9is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, A- is a pyridyl group, n is 0; - is -F; Ar2 is a benzothiazolyl group; R8 is -bR9mo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R2 is -F; Ar2 is a benzothiazolyl group; Rs is -fluoR9; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon 1 atom to which the R3 group is attached has the S configuration.

In another embodiment, Ar, is a pyridyl group, n is 0; R, is -F; Ar2 is a enzothiazolyl group; R8 is -iodo; and R9is -H. In another embodiment, the carbon atom to vhich the R3 group is attached has the R configuration. In another embodiment, the carbon itom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R, is -F, -CI, Br, or -I; &r2 is a benzothiazolyl group; R8 is -H; and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration, hi another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R, is -F; Ar2 is a benzothiazolyl group; R9is -H; and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R, is -F, -CI, Br, or -I; Ar2 is a benzothiazolyl group; R8 is -CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Arl is a pyridyl group, n is 0; R, is -F; Ar2 is a benzothiazolyl group; R8 is -CH3; and R9is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R1 is -F, -CI, Br, or -I; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R, is -F; Ar2 is a benzothiazolyl group; R8 is -H; and R9is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R, is -F, -CI, Br, or -I; Ar2 is a benzothiazolyl group; R8 is -CF3; and R9is -H. In another embodiment, the carbon

torn to which the R3 group is attached has the R configuration. In another embodiment, the arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R, is -F; Ar2 is a enzothiazolyl group; R8 is -CF3; and R9 is -H. In another embodiment, the carbon atom to /hich the R3 group is attached has the R configuration. In another embodiment, the carbon torn to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R, is -F, -CI, Br, or -I; \i2 is a benzothiazolyl group; R8 is -H; and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; - is -F; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -OCH2CH3. In another embodiment, the carbon itom to which the R3 group is attached has the R configuration. In another embodiment, the :arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R, is -F, -CI, Br, or -I; Ar2 is a benzothiazolyl group; R8 is -OCH2CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R, is -F; Ar2 is a benzothiazolyl group; R8 is -OCH2CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R, is -CH3; Ar2 is a benzothiazolyl group; R9is -H; and - is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R, is -CH3; Ar2 is a benzothiazolyl group; R8 is -H; and Jt^ is -chloR9. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Art is a pyridyl group, n is 0; R, is -CH3; Ar2 is a izothiazolyl group; R8 is -H; and R9 is -bR9mo. In another embodiment, the carbon atom to ich the R3 group is attached has the R configuration. In another embodiment, the carbon m to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R, is -CH3; Ar2 is a [izothiazolyl group; R8 is -H; and R9 is -fluoR9. In another embodiment, the carbon atom to lich the R3 group is attached has the R configuration. In another embodiment, the carbon OTI to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R, is -CH3; Ar2 is aizothiazolyl group; R8 is -H; and R* is -iodo. In another embodiment, the carbon atom to hich the R3 group is attached has the R configuration. In another embodiment, the carbon ;om to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R, is -CH3; Ar2 is a enzothiazolyl group; R8 is -halo; and R9 is -H. In another embodiment, the carbon atom to rtiich the R3 group is attached has the R configuration. In another embodiment, the carbon torn to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R, is -CH3; Ar2 is a ►enzothiazolyl group; R8 is -chloR9; and R9 is -H. In another embodiment, the carbon atom to vhich the R3 group is attached has the R configuration. In another embodiment, the carbon itom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R: is -CH3; Ar2 is aenzothiazolyl group; R8 is -bR9mo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R, is -CH3; Ax2 is a benzothiazolyl group; R8 is -fluoR9; and R9 is -H, In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. Li another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R, is -CH3; Ar2 is a benzothiazolyl group; R8 is -iodo; and R9, is -H. In another embodiment, the carbon atom to

hich the R3 group is attached has the R configuration. In another embodiment, the carbon om to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R, is -CH3; Ar2 is a snzothiazolyl group; R8 is -H; and R9 is -CH3. In another embodiment, the carbon atom to hich the R3 group is attached has the R configuration. In another embodiment, the carbon torn to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R, is -CH3; Ar2 is a enzothiazolyl group; R8 is -CH3; and R9 is -H. In another embodiment, the carbon atom to /hich the R3 group is attached has the R configuration. In another embodiment, the carbon itom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R, is -CH3; Ar2 is a )enzothiazolyl group; R8 is -H; and R9 is -CF3. In another embodiment, the carbon atom to tfhich the R3 group is attached has the R configuration. In another embodiment, the carbon itom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R, is -CH3; Ar2 is a benzothiazolyl group; R8 is -CF3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R, is -CH3; Ar2 is a benzothiazolyl group; R8 is -H; and R9is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R, is -CH3; Ar2 is a benzothiazolyl group; R8 is -OCH2CH3; and is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar, is a pyridyl group, n is 0; R, is -CF3; Ar2 is a benzothiazolyl group; and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.



In another embodiment, Ar1is a pyridyl group, n is 0; R, is -CF3; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R, is -CF3; Ar2 is a benzothiazolyl group; Rg is -H; and R9 is -chloro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar! is a pyridyl group, n is 0; R, is -CF3; Ar2 is a benzothiazolyl group; R8 is -H; and R$ is -bromo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R1 is -CF3; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -fluoro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
hi another embodiment, Ar1is a pyridyl group, n is 0; R, is -CF3; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R, is ~CF3; Ar2 is a benzothiazolyl group; R8 is -halo; and 1^ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R, is -CF3; Ar2 is a benzothiazolyl group; Rs is -chloro; and R$ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ax{ is a pyridyl group, n is 0; RY is -CF3; Ar2 is a benzothiazolyl group; R8 is -bromo; and R9 is -H. In another embodiment, the carbon atom to

which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; Kx is -CF3; Ar2 is a benzothiazolyl group; R8 is -fluoro; and Ro is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group, n is 0; Rj is -CF3; Ar2 is a benzothiazolyl group; Rg is -iodo; and Ro is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyridyl group, n is 0; R, is -CF3; Ar2 is a benzothiazolyl group; R8 is -H; and Ro is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; Rt is -CF3; Ar2 is a benzothiazolyl group; R8 is -CH3; and Ro is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyridyl group, n is 0; Kx is -CF3; Ar2 is a benzothiazolyl group; R8 is -H; and Ro is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; Kx is -CF3; Ar2 is a benzothiazolyl group; Rg is -CF3; and Ro is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
Li another embodiment, Axx is a pyridyl group, n is 0; R1 is -CF3; Ar2 is a benzothiazolyl group; R8 is -H; and Ro is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Ar1 is a pyridyl group, n is 0; R, is -CF3; Ar2 is a benzothiazolyl group; R8 is -OCH2CH3; and 1^ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group, n is 0; R1 is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -terf-butyl; and R> is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group, n is 0; R1 is -F; Ar2 is a benzothiazolyl group; R8 is -tert-butyl; and B^ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R1 is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -H; and R, is -tert-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group, n is 0; R1 is -F; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -terf-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration, hi another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group, n is 0; R! is -CH3; Ar2 is a benzothiazolyl group; R8 is -/erf-butyl; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group, n is 0; R1 is -CH3; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -tert-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Arl is a pyridyl group, n is 0; R, is -CH3; Ar2 is a benzothiazolyl group; R8 is -CH3; and R, is -CH3. In another embodiment, the carbon atom to

hich the R3 group is attached has the R configuration. In another embodiment, the carbon torn to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; Rj is -F, -CI, -Br, r -I; R4 is -H; Ar2 is a benzothiazolyl group; and R8 and Rg are -H. In another embodiment, ae carbon atom to which the R3 group is attached has the R configuration. In another mbodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; Ra is -F. R4 is -H; ^r2 is a benzothiazolyl group and Rg and R9 are -H. In another embodiment, the carbon atom o which the R3 group is attached has the R configuration. In another embodiment, the carbon itom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyrimidinyl group, p is 0; Rj is -F, -CI -Br, or ■I; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R1 is -F, -CI -Br, or -I; Ar2 is a benzothiazolyl group; R9 is -H; and R9 is -chloro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyrimidinyl group, p is 0; R1 is -F, -CI -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -bromo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R1 is -F, -Clt -Br, or -I; Ar2 is a benzothiazolyl group; R9 is -H; and R9 is -fluoro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; Rj is -F, -CI -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Ar1is a pyrimidinyl group, p is 0; Rt is -CI; Ar2 is a >enzothiazolyl group; R9 is -H; and R9 is -halo. In another embodiment, the carbon atom to vhich the R3 group is attached has the R configuration. In another embodiment, the carbon itom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; Rj is -CI; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -chloro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R1 is -CI; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -bromo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R, is -CI; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -fluoro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; Rj is -CI; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R, is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -halo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R, is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -chloro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R, is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R3 is -bromo; and R9 is -H. In another embodiment, the

carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyrimidinyl group, p is 0; R1 is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -fluoro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R! is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R9 is -iodo; and 1^ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; Rj is -F; Ar2 is a benzothiazolyl group; R9 is -halo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; Rj is -F; Ar2 is a benzothiazolyl group; R8 is -chloro; and R$ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; Rj is -F; Ar2 is a benzothiazolyl group; R8 is -bromo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; R{ is -F; Ar2 is a benzothiazolyl group; R8 is -fluoro; and R$ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyrimidinyl group, p is 0; Rj is -F; Ar2 is a benzothiazolyl group; R9 is -iodo; and Rp is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon / atom to which the R3 group is attached has the S configuration.

In another embodiment, Ar1 is a pyrimidinyl group, p is u; JR., -I; Ar2 is a benzothiazolyl group; R8 is -H; and R? is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; Kx is -F; Ar2 is a benzothiazolyl group; R9 is -H; and R$ is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; R, is -F, -CI, Br, or -I; Ar2 is a benzothiazolyl group; R8 is -CH3; and R$ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Arl is a pyrimidinyl group, p is 0; Rj is -F; Ar2 is a benzothiazolyl group; Rs is -CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; Rj is -F, -CI, Br, or -I; Ar2 is a benzothiazolyl group; R8 is -H; and R$ is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; Kx is -F; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyrimidinyl group, p is 0; Kx is -F, -CI, Br, or -I; Ar2 is a benzothiazolyl group; R8 is -CF3; and R$ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; Rt is -F; Ar2 is a benzothiazolyl group; R9 is -CF3; and R$ is -H. In another embodiment, the carbon atom to

which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar: is a pyrimidinyl group, p is 0; R1 is -F, -CI, Br, or -I; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; R1 is -F; Ar2 is a benzothiazolyl group; R8 is -H; and ^ is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R1 is -F, -CI, Br, or -I; Ar2 is a benzothiazolyl group; R8 is -OCH2CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; R1 is -F; Ar2 is a benzothiazolyl group; R8 is -OCH2CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; Kx is -CH3; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar j is a pyrimidinyl group, p is 0; R1 is -CH3; Ar2 is a benzothiazolyl group; R8 is -H; and 1^ is -chloro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; R1 is -CH3; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -bromo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Aix is a pyrimidinyl group, p is 0; R1 is -CH3; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -fluoro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R1 is -CH3; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Art is a pyrimidinyl group, p is 0; R1 is -CH3; Ar2 is a benzothiazolyl group; R8 is -halo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyrimidinyl group, p is 0; R1 is -CH3; Ar2 is a benzothiazolyl group; R8 is -chloro; and R9 is ~H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ax{ is a pyrimidinyl group, p is 0; R1 is -CH3; Ar2 is a benzothiazolyl group; R8 is -bromo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, is a pyrimidinyl group, p is 0; R, is -CH3; Ar2 is a benzothiazolyl group; R8 is -fluoro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R, is -CH3; Ar2 is a benzothiazolyl group; R8 is -iodo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R1 is -CH3; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -CH3. In another embodiment, the carbon atom to

vhich the R3 group is attached has the R configuration. In another embodiment, the carbon itom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R1 is -CH3; Ar2 is a senzothiazolyl group; R8 is -CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. Li another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; R1 is -CH3; Ar2 is a benzothiazolyl group; R8 is -H; and R, is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Art is a pyrimidinyl group, p is 0; R, is -CH3; Ar2 is a benzothiazolyl group; R8 is -CF3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R1 is -CH3; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R1 is -CH3; Ar2 is a benzothiazolyl group; R8 is -OCH2CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R1 is -CF3; Ar2 is a benzothiazolyl group; and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R1 is -CF3; Ar2 is a benzothiazolyl group; R8 is -H; and &$ is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Ar1is a pyrimidinyl group, p is 0; R1 is -CF3; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -chloro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; R1 is -CF3; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -bromo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R1 is -CF3; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -fluoro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R1 is -CF3; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; RA is -CF3; Ar2 is a benzothiazolyl group; R9 is -halo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R1 is -CF3; Ar2 is a benzothiazolyl group; R8 is -chloro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R1 is -CF3; Ar2 is a benzothiazolyl group; R8 is -bromo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar2 is a pyrimidinyl group, p is 0; R1 is -CF3; Ar2 is a benzothiazolyl group; R8 is -fluoro; and R9 is -H. In another embodiment, the carbon atom to

which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R1 is -CF3; Ar2 is a benzothiazolyl group; R8 is -iodo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; R1 is -CF3; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar: is a pyrimidinyl group, p is 0; R1 is -CF3; Ar2 is a benzothiazolyl group; Rs is -CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R1 is -CF3; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R1 is -CF3; Ar2 is a benzothiazolyl group; R8 is -CF3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Art is a pyrimidinyl group, p is 0; R, is -CF3; Ar2 is a benzothiazolyl group; R9 is -H; and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyrimidinyl group, p is 0; R, is -CF3; Ar2 is a benzothiazolyl group; R9 is OCH2CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the » carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Ar} is apyrimidinyl group, p is 0; R1 is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -tert-butyl; and R, is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; R1 is -F; Ar2 is a benzothiazolyl group; R9 is -ter/-butyl; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R1 is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -tert-butyL In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; Kx is -F; Ar2 is a benzothiazolyl group; R9 is -H; and R9 is -tert-butyL In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R1 is -CH3; Ar2 is a benzothiazolyl group; R8 is -tertf-butyl; and R9 is ~H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyrimidinyl group, p is 0; K{ is -CH3; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -tert-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axl is a pyrimidinyl group, p is 0; R1 is -CH3; Ar2 is a benzothiazolyl group; R8 is -CH3; and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R1 is -F, -CI, -Br, or -I; R4 is -H; Ar2 is a benzoimidazolyl group; and R8 and R, are -H. In another embodiment, the

carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyridyl group, n is 0; Rt is -F. R4 is -H; Ar2 is a benzoimidazolyl group and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyridyl group, n is 0; R1 is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -H; and R, is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group, n is 0; R1 is -F, -C\ -Br, or -I; Ar2 is a benzoimidazolyl group; R9 is -H; and R9 is -chloro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R1 is -F, -Clt -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -bromo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R1 is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -fluoro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group, n is 0; R, is -F, -CI -Br, or -I; Ar2 is a benzoimidazolyl group; R9 is -H; and R9 is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ax} is a pyridyl group, n is 0; R1 is -CI; Ar2 is a benzoimidazolyl group; R8 is -H; and R9, is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon > atom to which the R3 group is attached has the S configuration.

In another embodiment, Arl is a pyridyl group, n is 0; Rt is -CI; Ar2 is a benzoimidazolyl group; R9 is -H; and R9 is -chloro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R1 is -CI; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -bromo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R1 is -CI; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -fluoro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which 1he R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R1 is -CI; Ar2 is a benzoimidazolyl group; R9 is -H; and R9 is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R} is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -halo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R, is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -chloro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; Rl is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; Rs is -bromo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R! is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -fluoro; and R9 is -H. In another embodiment, the

carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R, is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -iodo; and R, is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R, is -F; Ar2 is a benzoimidazolyl group; R8 is -halo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration, hi another embodiment, the carbon ) atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R, is -F; Ar2 is a benzoimidazolyl group; R8 is -chloro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
> In another embodiment, Ar1is a pyridyl group, n is 0; R, is -F; Ar2 is a
benzoimidazolyl group; R8 is -bromo; and R, is -H. In another embodiment, the carbon atom
to which the R3 group is attached has the R configuration. In another embodiment, the carbon
atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R1 is -F; Ar2 is a ) benzoimidazolyl group; R8 is -fluoro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R, is -F; Ar2 is a benzoimidazolyl group; R8 is -iodo; and R9 is -H. In another embodiment, the carbon atom to
> which the R3 group is attached has the R configuration. In another embodiment, the carbon
atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R, is -F, -CI, Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration- In another embodiment, the ) carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Ar1is a pyridyl group, n is 0; R1 is -F; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; Rt is -F, -CI, Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Arl is a pyridyl group, n is 0; R1 is -F; Ar2 is a ' benzoimidazolyl group; R8 is -CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ax{ is a pyridyl group, n is 0; R, is -F, -CI, Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -H; and ^ is -CF3. In another embodiment, the carbon I atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R, is -F; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon ) atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R1 is -F, -CI, Br, or -I;
Ar2 is a benzoimidazolyl group; R8 is -CF3; and R9 is -H. In another embodiment, the carbon
atom to which the R3 group is attached has the R configuration. In another embodiment, the
carbon atom to which the R3 group is attached has the S configuration.
! In another embodiment, Ar1is a pyridyl group, n is 0; R, is -F; Ar2 is a
benzoimidazolyl group; R8 is -CF3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration, hi another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group, n is 0; R, is -F, -CI, Br, or -I; ) Ar2 is a benzoimidazolyl group; R8 is -H; and 1^ is -OCH2CH3. In another embodiment, the

carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R, is -F; Ar2 is a benzoimidazolyl group; R8 is -H; and R, is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R1 is -F, -CI, Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -OCH2CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R, is -F; Ar2 is a benzoimidazolyl group; R9 is -OCH2CH3; and R9, is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R, is -CH3; Ar2 is a benzoimidazolyl group; R8 is -H; and R§ is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R1 is -CH3; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -chloro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R, is -CH3; Ar2 is a benzoimidazolyl group; Rs is -H; and R9 is -bromo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R, is -CH3; Ar2 is a benzoimidazolyl group; R8 is -H; and R9, is -fluoro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Ax} is a pyridyl group, n is 0; Rt is -CH3; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ax{ is a pyridyl group, n is 0; R1 is -CH3; Ar2 is a benzoimidazolyl group; R8 is -halo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group, n is 0; R1 is -CH3; Ar2 is a benzoimidazolyl group; R8 is -chloro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group, n is 0; R1 is -CH3; Ar2 is a benzoimidazolyl group; R8 is -bromo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ai} is a pyridyl group, n is 0; R1 is -CH3; Ar2 is a benzoimidazolyl group; R8 is -fluoro; and R> is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R! is -CH3; Ar2 is a benzoimidazolyl group; R8 is -iodo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R1 is -CH3; Ar2 is a benzoimidazolyl group; R8 is -H; and Rp is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R1 is -CH3; Ar2 is a benzoimidazolyl group; R8 is -CH3; and R, is -H. In another embodiment, the carbon atom to

which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R, is -CH3; Ar2 is a benzoimidazolyl group; R8 is -H; and B^ is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group, n is 0; R, is -CH3; Ar2 is a benzoimidazolyl group; R8 is -CF3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration, hi another embodiment, the carbon 1 atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R1 is -CH3; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R, is -CH3; Ar2 is a benzoimidazolyl group; R8 is -OCH2CH3; and R9 is -H. Li another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group, n is 0; R, is -CF3; Ar2 is a benzoimidazolyl group; and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R, is -CF3; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R, is -CF3; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -chloro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Ar1is a pyridyl group, n is 0; R, is -CF3; Ar2 is a benzoimidazolyl group; R9 is -H; and R9 is -bromo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R, is -CF3; Ar2 is a benzoimidazolyl group; R8 is -H; and R, is -fluoro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R1 is -CF3; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R, is -CF3; Ar2 is a benzoimidazolyl group; R8 is -halo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R, is -CF3; Ar2 is a benzoimidazolyl group; R9 is -chloro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R, is -CF3; Ar2 is a benzoimidazolyl group; R8 is -bromo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R, is -CF3; Ar2 is a benzoimidazolyl group; R8 is -fluoro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R, is -CF3; Ar2 is a benzoimidazolyl group; R8 is -iodo; and R9 is -H. In another embodiment, the carbon atom to

which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R1 is -CF3; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration, hi another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R, is -CF3; Ar2 is a benzoimidazolyl group; R9 is -CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R, is -CF3; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R1 is -CF3; Ar2 is a benzoimidazolyl group; R8 is -CF3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R, is -CF3; Ar2 is a benzoimidazolyl group; R9 is -H; and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyridyl group, n is 0; R, is -CF3; Ar2 is a benzoimidazolyl group; R8 is -OCH2CH3; and R? is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R, is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -terf-butyl; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Ar1is a pyridyl group, n is 0; R, is -F; Ar2 is a benzoimidazolyl group; R8 is -tert-butyl; and R? is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R, is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -feyf-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R, is -F; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -terf-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R, is -CH3; Ar2 is a benzoimidazolyl group; R8 is -ferf-butyl; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R, is -CH3; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -ferf-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R, is -CH3; Ar2 is a benzoimidazolyl group; R8 is -CH3; and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R, is -F, -CI, -Br, or -I; R4 is -H; Ar2 is a benzoimidazolyl group; and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R, is -F. R4 is -H; Ar2 is a benzoimidazolyl group and R8 and 1^ are -H. In another embodiment, the carbon

atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R1 is -F, -CI -Br, or -I; Ar2 is a benzoimidazolyl group; R9 is -H; and 1^ is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R, is -F, -CI -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -chloro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R, is -F, -Cl( -Br, or -I; Ar2 is a benzoimidazolyl group; R9 is -H; and RQ is -bromo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R, is -F, -Cl^ -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -H; and 1^ is -fluoro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R, is -F, -Clf -Br, or -I; Ar2 is a benzoimidazolyl group; R9 is -H; and B^ is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R, is -CI; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R, is -CI; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -chloro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Aix is a pyrimidinyl group, p is 0; R, is -CI; Ar2 is a enzoimidazolyl group; R8 is -H; and R, is -bromo. In another embodiment, the carbon atom i which the R3 group is attached has the R configuration. In another embodiment, the carbon torn to which the R3 group is attached has the S configuration.
In another embodiment, Axj is a pyrimidinyl group, p is 0; R, is -CI; Ar2 is a (enzoimidazolyl group; R8 is -H; and R9 is -fluoro. In another embodiment, the carbon atom o which the R3 group is attached has the R configuration. In another embodiment, the carbon torn to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; R1 is -CI; Ar2 is a >enzoimidazolyl group; R9 is -H; and R9 is -iodo. In another embodiment, the carbon atom to vhich the R3 group is attached has the R configuration. In another embodiment, the carbon Ltom to which the R3 group is attached has the S configuration.
In another embodiment, Arl is a pyrimidinyl group, p is 0; R1 is -F, -CI, -Br, >r -I; Ar2 is a benzoimidazolyl group; Rs is -halo; and R9 is -H. In another embodiment, the ;arbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R1 is -F, -CI, -Br, 3r -I; Ar2 is a benzoimidazolyl group; R8 is -chloro; and R9 is -H.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R1 is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -bromo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R, is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -fluoro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ai} is a pyrimidinyl group, p is 0; R1 is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -iodo; and R, is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Aix is a pyrimidinyl group, p is 0; R1 is -F; Ar2 is a benzoimidazolyl group; R8 is -halo; and R1 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyrimidinyl group, p is 0; R1 is -F; Ar2 is a benzoimidazolyl group; R8 is -chloro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R1 is -F; Ar2 is a benzoimidazolyl group; R8 is -bromo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R1 is -F; Ar2 is a benzoimidazolyl group; R8 is -fluoro; and R» is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyrimidinyl group, p is 0; R1 is -F; Ar2 is a benzoimidazolyl group; R9 is -iodo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R1 is -F, -CI, Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R! is -F; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Art is a pyrimidinyl group, p is 0; R, is -F, -CI, Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -CH3; and ^ is -H. In another embodiment, the

carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Arl is a pyrimidinyl group, p is 0; R, is -F; Ar2 is a benzoimidazolyl group; R9 is -CH3; and R, is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R, is -F, -CI, Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R1 is -F; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyrimidinyl group, p is 0; R1 is -F, -CI, Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -CF3; and ^ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R1 is -F; Ar2 is a benzoimidazolyl group; R8 is -CF3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar2 is a pyrimidinyl group, p is 0; R1 is -F, -CI, Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; R1 is -F; Ar2 is a benzoimidazolyl group; R8 is -H; and ^ is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Ar1is a pyrimidinyl group, p is 0; R1 is -F, -CI, Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -OCH2CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; R1 is -F; Ar2 is a benzoimidazolyl group; R8 is -OCH2CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the sarbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ax} is a pyrimidinyl group, p is 0; R1 is -CH3; Ar2 is a benzoimidazolyl group; R9 is -H; and R9 is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyrimidinyl group, p is 0; R, is -CH3; Ar2 is a benzoimidazolyl group; R8 is -H; and R, is -chloro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyrimidinyl group, p is 0; R, is -CH3; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -bromo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; R1 is -CH3; Ar2 is a benzoimidazolyl group; R9 is -H; and R9 is -fluoro. In another embodiment, the carbon atom :o which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
Li another embodiment, Axx is a pyrimidinyl group, p is 0; R1 is -CH3; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
Li another embodiment, Axx is a pyrimidinyl group, p is 0; R1 is -CH3; Ar2 is a benzoimidazolyl group; R8 is -halo; and R9 is -H. In another embodiment, the carbon atom to

rtiich the R3 group is attached has the R configuration. In another embodiment, the carbon torn to which the R3 group is attached has the S configuration.
hi another embodiment, Axx is a pyrimidinyl group, p is 0; K^ is -CH3; Ar2 is a >enzoimidazolyl group; R8 is -chloro; and R9 is -H. In another embodiment, the carbon atom o which the R3 group is attached has the R configuration. In another embodiment, the carbon itom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; Kx is -CH3; Ar2 is a Denzoimidazolyl group; Rs is -bromo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyrimidinyl group, p is 0; Kx is -CH3; Ar2 is a benzoimidazolyl group; R8 is -fluoro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; Rt is -CH3; Ar2 is a benzoimidazolyl group; R9 is -iodo; and 1^ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; Kx is -CH3; Ar2 is a benzoimidazolyl group; R8 is -H; and ^ is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; Kx is -CH3; Ar2 is a benzoimidazolyl group; R9 is ~CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; R1 is -CH3; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Aix is a pyrimidinyl group, p is 0; R, is -CH3; Ar2 is a benzoimidazolyl group; R8 is -CF3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; R1 is -CH3; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Art is a pyrimidinyl group, p is 0; Rt is -CH3; Ar2 is a benzoimidazolyl group; R8 is -OCH2CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the " carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; R1 is -CF3; Ar2 is a benzoimidazolyl group; and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R1 is -CF3; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R1 is -CF3; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -chloro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyrimidinyl group, p is 0; R1 is -CF3; Ar2 is a benzoimidazolyl group; R8 is -H; and K^ is -bromo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyrimidinyl group, p is 0; R, is -CF3; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -fluoro. In another embodiment, the carbon atom

to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R! is -CF3; Ar2 is a benzoimidazolyl group; R8 is -H; and 1^ is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; R1 is -CF3; Ar2 is a benzoimidazolyl group; R8 is -halo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R! is -CF3; Ar2 is a benzoimidazolyl group; R8 is -chloro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R1 is -CF3; Ar2 is a benzoimidazolyl group; R8 is -bromo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyrimidinyl group, p is 0; R1 is -CF3; Ar2 is a benzoimidazolyl group; R8 is -fluoro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
Li another embodiment, Ar1 is a pyrimidinyl group, p is 0; R1 is -CF3; Ar2 is a benzoimidazolyl group; R8 is -iodo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyrimidinyl group, p is 0; Kx is -CF3; Ar2 is a benzoimidazolyl group; R8 is -H; and R, is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Ar1is a pyrimidinyl group, p is 0; R, is -CF3; Ar2 is a benzoimidazolyl group; R8 is -CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R, is -CF3; Ar2 is a benzoimidazolyl group; R9 is -H; and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration, hi another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R, is -CF3; Ar2 is a benzoimidazolyl group; R8 is -CF3; and R9 is -H. in another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R, is -CF3; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R, is -CF3; Ar2 is a benzoimidazolyl group; R8 is -OCH2CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R, is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -ter/-butyl; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R, is -F; Ar2 is a benzoimidazolyl group; R8 is -ter/-butyl; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R, is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -tert-butyl In another embodiment,

tie carbon atom to which the R3 group is attached has the R configuration. In another mbodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R, is -F; Ar2 is a >enzoimidazolyl group; R8 is -H; and R9 is -terf-butyl. In another embodiment, the carbon itom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; ^ is -CH3; Ar2 is a benzoimidazolyl group; R8 is -tert-butyl; and R» is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar2 is a pyrimidinyl group, p is 0; Kx is -CH3; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -tert-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; is -CH3; Ar2 is a benzoimidazolyl group; R8 is -CH3; and R1 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R1 is -F, -CI, -Br, or -I; R4 is -H; Ar2 is a benzooxazolyl group; and R8 and R1 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R1 is -F. R4 is -H; Ar2 is a benzooxazolyl group and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R! is -F, -CI -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, AR1 is a pyridyl group, n is 0; R{ is -F, -Cl( -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -H; and 1^ is -chloro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; Rt is -F, -Cl( -Br, or -I; Ar2 is a benzooxazolyl group; R9 is -H; and 0$ is -bromo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ary is a pyridyl group, n is 0; Ri is -F, -CI -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -fluoro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R1 is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ax{ is a pyridyl group, n is 0; R, is -CI; Ar2 is a benzooxazolyl group; R9 is -H; and ^ is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R1 is -CI; Ar2 is a benzooxazolyl group; R9 is -H; and R9 is -chloro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R1 is -CI; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -bromo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Art is a pyridyl group, n is 0; ^ is -CI; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -fluoro. In another embodiment, the carbon atom to

which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R1 is -CI; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ai{ is a pyridyl group, n is 0; R! is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R9 is -halo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axl is a pyridyl group, n is 0; R1 is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -chloro; and R9 is -H.
In another embodiment, Aix is a pyridyl group, n is 0; R! is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -bromo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; ^ is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -fluoro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R1 is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R9 is -iodo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group, n is 0; R1 is -F; Ar2 is a benzooxazolyl group; R8 is -halo; and R, is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
Li another embodiment, Ar1 is a pyridyl group, n is 0; R1 is -F; Ar2 is a benzooxazolyl group; Rs is -chloro; and R9 is -H. In another embodiment, the carbon atom to

which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyridyl group, n is 0; Rt is -F; Ar2 is a benzooxazolyl group; R8 is -bromo; and ^ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group, n is 0; Kx is -F; Ar2 is a benzooxazolyl group; R8 is -fluoro; and R, is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group, n is 0; R1 is -F; Ar2 is a benzooxazolyl group; R8 is -iodo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyridyl group, n is 0; Kx is -F, -CI, Br, or -I; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyridyl group, n is 0; Kx is -F; Ar2 is a lenzooxazolyl group; R8 is -H; and R9 is -CH3. In another embodiment, the carbon atom to vhich the R3 group is attached has the R configuration. In another embodiment, the carbon itom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyridyl group, n is 0; R1 is -F, -CI, Br, or -I; \r2 is a benzooxazolyl group; R8 is -CH3; and B^ is -HL In another embodiment, the carbon itom to which the R3 group is attached has the R configuration. In another embodiment, the sarbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Arl is a pyridyl group, n is 0; Ri is -F; Ar2 is a benzooxazolyl group; R8 is -CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Axx is a pyridyl group, n is 0; R, is -F, -CI, Br, or -I; \r2 is a benzooxazolyl group; R8 is -H; and R9 is -CF3. In another embodiment, the carbon torn to which the R3 group is attached has the R configuration. In another embodiment, the ;arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyridyl group, n is 0; R1 is -F; Ar2 is a >enzooxazolyl group; R8 is -H; and 1^ is -CF3. In another embodiment, the carbon atom to Artiich the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyridyl group, n is 0; R1 is -F, -CI, Br, or -I; Ar2 is a benzooxazolyl group; R8 is -CF3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aij is a pyridyl group, n is 0; Rt is -F; Ar2 is a benzooxazolyl group; R8 is -CF3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R1 is -F, -CI, Br, or -I; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; Rt is -F; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Art is a pyridyl group, n is 0; R1 is -F, -CI, Br, or -I; Ar2 is a benzooxazolyl group; R8 is -OCH2CH3; and R, is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; Kx is -F; Ar2 is a benzooxazolyl group; R8 is -OCH2CH3; and R9 is -H. In another embodiment, the carbon

om to which the R3 group is attached has the R configuration. In another embodiment, the arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group, n is 0; Kx is -CH3; Ar2 is a enzooxazolyl group; Rs is -H; and R9 is -halo. In another embodiment, the carbon atom to /hich the R3 group is attached has the R configuration. In another embodiment, the carbon torn to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group, n is 0; R1 is -CH3; Ar2 is a )enzooxazolyl group; R8 is -H; and R9 is -chloro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyridyl group, n is 0; R1 is -CH3; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -bromo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyridyl group, n is 0; Kx is -CH3; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -fluoro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Asx is a pyridyl group, n is 0; R, is -CH3; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Art is a pyridyl group, n is 0; Rt is -CH3; Ar2 is a benzooxazolyl group; R8 is -halo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyridyl group, n is 0; R1 is -CH3; Ar2 is a benzooxazolyl group; R8 is -chloro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Axx is a pyridyl group, n is 0; Rt is -CH3; Ar2 is a enzooxazolyl group; Rs is -bromo; and R, is -H. In another embodiment, the carbon atom to vhich the R3 group is attached has the R configuration. In another embodiment, the carbon torn to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R{ is -CH3; Ar2 is a >enzooxazolyl group; R8 is -fluoro; and R, is -H. In another embodiment, the carbon atom to vhich the R3 group is attached has the R configuration. In another embodiment, the carbon itom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R, is -CH3; Ar2 is a )enzooxazolyl group; R9 is -iodo; and R9 is -H, In another embodiment, the carbon atom to ;vhich the R3 group is attached has the R configuration. In another embodiment, the carbon itom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R: is -CH3; Ar2 is a t>enzooxazolyl group; R8 is -H; and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration, hi another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyridyl group, n is 0; R, is -CH3; Ar2 is a benzooxazolyl group; R9 is -CH3; and R» is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R1 is -CH3; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R1 is -CH3; Ar2 is a benzooxazolyl group; R8 is -CF3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Arl is a pyridyl group, n is 0; R1 is -CH3; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -OCH2CH3. In another embodiment, the carbon

torn to which the R3 group is attached has the R configuration- In another embodiment, the arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyridyl group, n is 0; R1 is -CH3; Ar2 is a ►enzooxazolyl group; R8 is -OCH2CH3; and R> is -H. In another embodiment, the carbon torn to which the R3 group is attached has the R configuration. In another embodiment, the arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R1 is -CF3; Ar2 is a >enzooxazolyl group; and R8 and R9 are -H. In another embodiment, the carbon atom to vhich the R3 group is attached has the R configuration. In another embodiment, the carbon itom to which the R3 group is attached has the S configuration.
In another embodiment, Ar2 is a pyridyl group, n is 0; Kx is -CF3; Ar2 is a >enzooxazolyl group; R8 is -H; and R9 is -halo. In another embodiment, the carbon atom to >vhich the R3 group is attached has the R configuration. In another embodiment, the carbon itom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; Kx is -CF3; Ar2 is a aenzooxazolyl group; R8 is -H; and R9 is -chloro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyridyl group, n is 0; R, is -CF3; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -bromo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group, n is 0; Kx is -CF3; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -fluoro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration, hi another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyridyl group, n is 0; R1 is -CF3; Ar2 is a benzooxazolyl group; R8 is -H; and R? is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Ar{ is a pyridyl group, n is 0; R2 is -CF3; Ar2 is a benzooxazolyl group; R8 is -halo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group, n is 0; R1 is -CF3; Ar2 is a benzooxazolyl group; R8 is -chloro; and Rp is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R1 is -CF3; Ar2 is a benzooxazolyl group; R9 is -bromo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuratioa
In another embodiment, AR1 is a pyridyl group, n is 0; R, is -CF3; Ar2 is a benzooxazolyl group; R9 is -fluoro; and Rp is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group, n is 0; R2 is -CF3; Ar2 is a benzooxazolyl group; R8 is -iodo; and Rs is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group, n is 0; R1 is -CF3; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R1 is -CF3; Ar2 is a benzooxazolyl group; R8 is -CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ax} is a pyridyl group, n is 0; R, is -CF3; Ar2 is a benzooxazolyl group; R8 is -H; and Rp is -CF3. In another embodiment, the carbon atom to

which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R1 is -CF3; Ar2 is a benzooxazolyl group; R9 is -CF3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
Li another embodiment, AR1 is a pyridyl group, n is 0; Kx is -CF3; Ar2 is a benzooxazolyl group; R8 is -H; and Rp is -OCH2CH3, In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R1 is -CF3; Ar2 is a benzooxazolyl group; R8 is -OCH2CH3; and R? is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyridyl group, n is 0; R, is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R9 is -ferf-butyl; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R3 is -F; Ar2 is a benzooxazolyl group; R8 is -tert-butyl; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group, n is 0; R1 is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -tert-butyL In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R1 is -F; Ar2 is a benzooxazolyl group; R8 is -H; and ^ is -ter/-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Ar1is a pyridyl group, n is 0; R, is -CH3; Ar2 is a benzooxazolyl group; Rs is -terf-butyl; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which die R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; Kx is -CH3; Ar2 is a benzooxazolyl group; R9 is -H; and R9 is -terf-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group, n is 0; R1 is -CH3; Ar2 is a benzooxazolyl group; R8 is -CH3; and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; Kx is -F, -CI, -Br, or -I; R4 is -H; Ar2 is a benzooxazolyl group; and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R1 is -F. R9 is -H; Ar2 is a benzooxazolyl group and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R} is -F, -CI -Br, or -I; Ar2 is a benzooxazolyl group; R9 is -H; and 1^ is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R1 is -F, -CI -Br, or -I; Ar2 is a benzooxazolyl group; R9 is -H; and R? is -chloro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R2 is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -H; and R> is -bromo. In another embodiment, the

carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; Kx is -F, -Cl^ -Br, or -I; Ar2 is a benzooxazolyl group; Rs is -H; and R9 is -fluoro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; R1 is -F, -C\ -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -H; and 19 is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar j is a pyrimidinyl group, p is 0; R, is -CI; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar: is a pyrimidinyl group, p is 0; R, is -CI; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -chloro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AxY is a pyrimidinyl group, p is 0; R1 is -CI; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -bromo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; Kx is -CI; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -fluoro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; Rt is -CI; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Axx is a pyrimidinyl group, p is 0; R3 is ~F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -halo; and E^ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyrimidinyl group, p is 0; R1 is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R9 is -chloro; and Rp is -H.
In another embodiment, Axx is a pyrimidinyl group, p is 0; R1 is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R9 is -bromo; and Rp is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axl is a pyrimidinyl group, p is 0; R1 is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -fluoro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; Rt is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -iodo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; R, is -F; Ar2 is a benzooxazolyl group; R8 is -halo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R1 is -F; Ar2 is a benzooxazolyl group; R8 is -chloro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar5 is a pyrimidinyl group, p is 0; R1 is -F; Ar2 is a benzooxazolyl group; R8 is -bromo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon ' atom to which the R3 group is attached has the S configuration.

In another embodiment, Ar1is a pyrimidinyl group, p is 0; R1 is -F; Ar2 is a benzooxazolyl group; R8 is -fluoro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyrimidinyl group, p is 0; R1 is -F; Ar2 is a benzooxazolyl group; Rs is -iodo; and R> is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; R1 is -F, -CI, Br, or -I; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R1 is -F; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; R1 is -F, -CI, Br, or -I; Ar2 is a benzooxazolyl group; R8 is -CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Arl is a pyrimidinyl group, p is 0; R[ is -F; Ar2 is a benzooxazolyl group; R8 is -CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R1 is -F, -CI, Br, or -I; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R1 is -F; Ar2 is a benzooxazolyl group; R8 is -H; and R? is -CF3. In another embodiment, the carbon atom to

which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Art is a pyrimidinyl group, p is 0; R, is -F, -CI, Br, or -I; Ar2 is a benzooxazolyl group; R8 is -CF3; and R> is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R1 is -F; Ar2 is a benzooxazolyl group; R8 is -CF3; and 1^ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyrimidinyl group, p is 0; Rt is -F, -CI, Br, or -I; Ar2 is a benzooxazolyl group; R8 is -H; and ~R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Art is a pyrimidinyl group, p is 0; R1 is -F; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R1 is -F, -CI, Br, or -I; Ar2 is a benzooxazolyl group; R8 is -OCH2CH3; and T^ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Art is a pyrimidinyl group, p is 0; R1 is -F; Ar2 is a benzooxazolyl group; R8 is -OCH2CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R) is -CH3; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Axx is a pyrimidinyl group, p is 0; R1 is -CH3; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -chloro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; R1 is -CH3; Ar2 is a . benzooxazolyl group; R8 is -H; and R9 is -bromo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyrimidinyl group, p is 0; R1 is -CH3; Ar2 is a benzooxazolyl group; R8 is -H; and "S^ is -fluoro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyrimidinyl group, p is 0; R, is -CH3; Ar2 is a benzooxazolyl group; R9 is -H; and R9 is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R] is -CH3; Ar2 is a benzooxazolyl group; R8 is -halo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyrimidinyl group, p is 0; R1 is -CH3; Ar2 is a benzooxazolyl group; R8 is -chloro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R1 is -CH3; Ar2 is a benzooxazolyl group; R8 is -bromo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyrimidinyl group, p is 0; R( is -CH3; Ar2 is a benzooxazolyl group; R8 is -fluoro; and F^ is -H. In another embodiment, the carbon atom to

vhich the R3 group is attached has the R configuration. In another embodiment, the carbon itom to which the R3 group is attached has the S configuration
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R1 is -CH3; Ar2 is a benzooxazolyl group; R8 is -iodo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; R1 is -CH3; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R1 is -CH3; Ar2 is a benzooxazolyl group; R8 is -CH3; and R? is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; R, is -CH3; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; R1 is -CH3; Ar2 is a benzooxazolyl group; R8 is -CF3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Mx is a pyrimidinyl group, p is 0; R1 is -CH3; Ar2 is a benzooxazolyl group; R8 is -H; and 0$ is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyrimidinyl group, p is 0; R1 is -CH3; Ar2 is a benzooxazolyl group; R8 is -OCH2CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Art is a pyrimidinyl group, p is 0; R1 is -CF3; Ar2 is a benzooxazolyl group; and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyrimidinyl group, p is 0; R2 is -CF3; Ar2 is a benzooxazolyl group; R9 is -H; and R9 is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; R1 is -CF3; Ar2 is a benzooxazolyl group; R8 is -H; and 1^ is -chloro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R1 is -CF3; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -bromo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; R, is -CF3; Ar2 is a benzooxazolyl group; R8 is -H; and R? is -fluoro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyrimidinyl group, p is 0; R1 is -CF3; Ar2 is a benzooxazolyl group; R8 is -H; and R> is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R1 is -CF3; Ar2 is a benzooxazolyl group; R8 is -halo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; Kx is -CF3; Ar2 is a » benzooxazolyl group; R8 is -chloro; and R9 is -H. In another embodiment, the carbon atom to

which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; Ra is -CF3; Ar2 is a benzooxazolyl group; R8 is -bromo; and 1^ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R1 is -CF3; Ar2 is a benzooxazolyl group; R8 is -fluoro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyrimidinyl group, p is 0; R, is -CF3; Ar2 is a benzooxazolyl group; R8 is -iodo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyrimidinyl group, p is 0; R1 is -CF3; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyrimidinyl group, p is 0; R1 is -CF3; Ar2 is a benzooxazolyl group; R9 is -CH3; and Rp is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; R1 is -CF3; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R1 is -CF3; Ar2 is a benzooxazolyl group; R9 is -CF3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

La another embodiment, AR1 is a pyrimidinyl group, p is 0; R, is -CF3; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar2 is a pyrimidinyl group, p is 0; R1 is -CF3; Ar2 is a benzooxazolyl group; R8 is -OCH2CH3; and Rp is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyrimidinyl group, p is 0; R1 is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -/erf-butyl; and R9 is -EL In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyrimidinyl group, p is 0; R1 is -F; Ar2 is a benzooxazolyl group; R8 is -fert-butyl; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyrimidinyl group, p is 0; R1 is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -tert-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyrimidinyl group, p is 0; ^ is -F; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -terf-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R1 is -CH3; Ar2 is a benzooxazolyl group; R8 is -terf-butyl; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration, ha another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyrimidinyl group, p is 0; R1 is -CH3; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -terf-butyl. In another embodiment, the carbon atom

to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyrimidinyl, p is 0; R1 is -CH3; Ar2 is a benzooxazolyl group; R8 is -CH3; and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R1 is -F, -CI, -Br, or -I; R4 is -H; Ar2 is a benzothiazolyl group; and Rg and R§ are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R1 is -F. R4 is -H; Ar2 is a benzothiazolyl group and R8 and Rg are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group and n is 0; R1 is -F, -CI -Br, or -I; Ar2 is a benzothiazolyl group; R9 is -H; and R9 is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group and n is 0; Rt is -F, -Cl( -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -chloro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R1 is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R9 is -H; and R9 is -bromo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar2 is a pyridyl group and n is 0; R1 is -F, -Cl( -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -fluoro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

]ii another embodiment, Axx is a pyridyl group and n is 0; R1 is -F, -CI, -Br, or -Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -iodo. In another embodiment, the carbon ;om to which the R3 group is attached has the R configuration. In another embodiment, the irbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group and n is 0; R1 is -CI; Ar2 is a enzothiazolyl group; R9 is -H; and R, is -halo. In another embodiment, the carbon atom to 'hich the R3 group is attached has the R configuration. In another embodiment, the carbon torn to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group and n is 0; R1 is -CI; Ar2 is a enzothiazolyl group; R8 is -H; and R9 is -chloro. In another embodiment, the carbon atom to /hich the R3 group is attached has the R configuration. In another embodiment, the carbon torn to which the R3 group is attached has the S configuration.
In another embodiment, Air is a pyridyl group and n is 0; Rl is -CI; Ar2 is a (enzothiazolyl group; R8 is -H; and R9 is -bromo. In another embodiment, the carbon atom to vhich the R3 group is attached has the R configuration. In another embodiment, the carbon torn to which the R3 group is attached has the S configuration.
In another embodiment, Ax} is a pyridyl group and n is 0; R1 is -CI; Ar2 is a >enzothiazolyl group; R8 is -H; and R9 is -fluoro. In another embodiment, the carbon atom to vhich the R3 group is attached has the R configuration. In another embodiment, the carbon itom to which the R3 group is attached has the S configuration.
hi another embodiment, Ar1is a pyridyl group and n is 0; Rt is -CI; Ar2 is a ^enzothiazolyl group; R8 is -H; and Rp is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration, hi another embodiment, the carbon itom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group and n is 0; Kx is -F, -CI, -Br, or -[; Ar2 is a benzothiazolyl group; R8 is -halo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration, hi another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar} is a pyridyl group and n is 0; R1 is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -chloro; and R9 is -H. In another embodiment, the

carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group and n is 0; R1 is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -bromo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group and n is 0; R1 is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; Rs is -fluoro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group and n is 0; R, is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -iodo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyridyl group and n is 0; R1 is -F; Ar2 is a benzothiazolyl group; R8 is -halo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyridyl group and n is 0; R1 is -F; Ar2 is a benzothiazolyl group; R8 is -chloro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyridyl group and n is 0; R1 is -F; Ar2 is a benzothiazolyl group; R8 is -bromo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R1 is -F; Ar2 is a benzothiazolyl group; R8 is -fluoro; and R? is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Ar1is a pyridyl group and n is 0; Rt is -F; Ar2 is a benzothiazolyl group; R8 is -iodo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration, hi another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; Kx is -F, -CI, Br, or -I; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group and n is 0; R1 is -F; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group and n is 0; R1 is -F, -CI, Br, or -I; Ar2 is a benzothiazolyl group; R9 is -CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Arl is a pyridyl group and n is 0; R1 is -F; Ar2 is a benzothiazolyl group; R9 is -CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyridyl group and n is 0; R, is -F, -CI, Br, or -I; Ar2 is a benzothiazolyl group; R9 is -H; and R9 is -CF3. Li another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R, is -F; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -CF3, In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R, is -F, -CI, Br, or -I; Ar2 is a benzothiazolyl group; R8 is -CF3; and R, is -H. In another embodiment, the carbon

atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R, is -F; Ar2 is a benzothiazolyl group; R8 is -CF3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R, is -F, -CI, Br, or -I; Ar2 is a benzothiazolyl group; R9 is -H; and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R, is -F; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R1 is -F, -CI, Br, or -I; Ar2 is a benzothiazolyl group; R8 is -OCH2CH3; and 11$ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R, is -F; Ar2 is a benzothiazolyl group; R8 is -OCH2CH3; and Rp is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R, is -CH3; Ar2 is a benzothiazolyl group; R8 is ~H; and R9 is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R, is -CH3; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -chloro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Aix is a pyridyl group and n is 0; R, is -CH3; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -bromo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
hi another embodiment, Aix is a pyridyl group and n is 0; R: is -CH3; Ar2 is a benzothiazolyl group; R9 is -H; and R? is -fluoro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ax{ is a pyridyl group and n is 0; R9 is -CH3; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ax} is a pyridyl group and n is 0; R1 is -CH3; Ar2 is a benzothiazolyl group; R8 is -halo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar{ is a pyridyl group and n is 0; R, is -CH3; Ar2 is a benzothiazolyl group; R8 is -chloro; and R> is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
Li another embodiment, Ar1 is a pyridyl group and n is 0; R2 is -CH3; Ar2 is a benzothiazolyl group; R9 is -bromo; and Rp is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Art is a pyridyl group and n is 0; R1 is -CH3; Ar2 is a benzothiazolyl group; R9 is -fluoro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar3 is a pyridyl group and n is 0; R5 is -CH3; Ar2 is a benzothiazolyl group; R8 is -iodo; and R9 is -H. In another embodiment, the carbon atom to

which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Art is a pyridyl group and n is 0; R1 is -CH3; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group and n is 0; R1 is -CH3; Ar2 is a benzothiazolyl group; R8 is -CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyridyl group and n is 0; R1 is -CH3; Ar2 is a benzothiazolyl group; R9 is -H; and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
hi another embodiment, Ara is a pyridyl group and n is 0; R1 is -CH3; Ar2 is a benzothiazolyl group; R9 is -CF3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
La another embodiment, Ar1is a pyridyl group and n is 0; R! is -CH3; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyridyl group and n is 0; Rt is -CH3; Ar2 is a benzothiazolyl group; R8 is -OCH2CH3; and R9 is -H, In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyridyl group and n is 0; R1 is -CF3; Ar2 is a benzothiazolyl group; and R8 and Rg are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Axx is a pyridyl group and n is 0; Ri is -CF3; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyridyl group and n is 0; R1 is -CF3; Ar2 is a benzothiazolyl group; R9 is -H; and R9 is -chloro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group and n is 0; R1 is -CF3; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -bromo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group and n is 0; R1 is -CF3; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -fluoro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group and n is 0; R, is -CF3; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Arl is a pyridyl group and n is 0; R1 is -CF3; Ar2 is a benzothiazolyl group; R8 is -halo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration, hi another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group and n is 0; R1 is -CF3; Ar2 is a benzothiazolyl group; R9 is -chloro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R} is -CF3; Ar2 is a benzothiazolyl group; R8 is -bromo; and R9 is -H. In another embodiment, the carbon atom to

vhich the R3 group is attached has the R configuration. In another embodiment, the carbon Ltom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R1 is -CF3; Ar2 is a >enzothiazolyl group; R8 is -fluoro; and R, is -H. In another embodiment, the carbon atom to vhich the R3 group is attached has the R configuration. In another embodiment, the carbon itom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R1 is -CF3; Ar2 is a benzothiazolyl group; R8 is -iodo; and R, is -H. In another embodiment, the carbon atom to ivhich the R3 group is attached has the R configuration. In another embodiment, the carbon itom to which the R3 group is attached has the S configuration.
In another embodiment, Ar} is a pyridyl group and n is 0; R, is -CF3; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R1 is -CF3; Ar2 is a benzothiazolyl group; R9 is -CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group and n is 0; R1 is -CF3; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration, hi another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group and n is 0; Kx is -CF3; Ar2 is a benzothiazolyl group; R8 is -CF3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration, hi another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R, is -CF3; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Axx is a pyridyl group and n is 0; R1 is -CF3; Ar2 is a benzothiazolyl group; R8 is -OCH2CH3; and R, is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration- In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyridyl group and n is 0; R, is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R9 is -/erf-butyl; and R, is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group and n is 0; R1 is -F; Ar2 is a > benzothiazolyl group; R8 is -tert-butyl; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group and n is 0; R1 is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -terf-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group and n is 0; R2 is -F; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -tert-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group and n is 0; R1 is -CH3; Ar2 is a benzothiazolyl group; R8 is -/erf-butyl; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group and n is 0; R1 is -CH3; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -tert-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group and n is 0; R1 is -CH3; Ar2 is a ) benzothiazolyl group; R8 is -CH3; and R9 is -CH3. In another embodiment, the carbon atom to

which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Art is a pyriminidyl group and p is 0; R, is -F, -CI, -Br, or -I; R4 is -H; Ar2 is a benzothiazolyl group; and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyriminidyl group and p is 0; R1 is -F. R4 is -H; Ar2 is a benzothiazolyl group and Rg and R9 are -EL In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyriminidyl group and p is 0; Rt is -F, -Clt -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -H; and ^ is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyriminidyl group and p is 0; R! is -F, -C\ -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -H; and 1^ is -chloro. hi another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyriminidyl group and.p is 0; R1 is -F, -Clt -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -H; and ^ is -bromo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyriminidyl group and p is 0; R1 is -F, -CI -Br, or -I; Ar2 is a benzothiazolyl group; R9 is -H; and R9 is -fluoro. hi another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyriminidyl group and p is 0; R{ is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, AR1 is a pyriminidyl group and p is 0; R1 is -CI; Ar2 is a benzothiazolyl group; R8 is -H; and R, is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration, in another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Art is a pyriminidyl group and p is 0; R1 is -CI; Ar2 is a benzothiazolyl group; R8 is -H; and R1 is -chloro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar2 is a pyriminidyl group and p is 0; R1 is -CI; Ar2 is a benzothiazolyl group; R8 is -H; and 1^ is -bromo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyriminidyl group and p is 0; R{ is -CI; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -fluoro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyriminidyl group and p is 0; R1 is -CI; Ar2 is a benzothiazolyl group; R9 is -H; and R? is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration, hi another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyriminidyl group and p is 0; R1 is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R9 is -halo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyriminidyl group and p is 0; R1 is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -chloro; and R, is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyriminidyl group and p is 0; R1 is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -bromo; and R9 is -H. In another embodiment,

he carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyriminidyl group and p is 0; R, is -F, -CI, -3r, or -I; Ar2 is a benzothiazolyl group; R9 is -fluoro; and R9 is -H. In another embodiment, iie carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyriminidyl group and p is 0; R! is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -iodo; and R, is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyriminidyl group and p is 0; R1 is -F; Ar2 is a benzothiazolyl group; R8 is -halo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyriminidyl group and p is 0; R1 is -F; Ar2 is a benzothiazolyl group; R8 is -chloro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyriminidyl group and p is 0; R1 is -F; Ar2 is a benzothiazolyl group; R9 is -bromo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyriminidyl group and p is 0; R1 is -F; Ar2 is a benzothiazolyl group; R8 is -fluoro; and B^ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyriminidyl group and p is 0; R1 is -F; Ar2 is a benzothiazolyl group; R8 is -iodo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, AR1 is a pyriminidyl group and p is 0; R, is -F, -CI, 3r, or -I; Ar2 is a benzothiazolyl group; R8 is -H; and is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyriminidyl group and p is 0; R1 is -F; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyriminidyl group and p is 0; R1 is -F, -CI, Br, or -I; Ar2 is a benzothiazolyl group; R8 is -CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Arl is a pyriminidyl group and p is 0; R1 is -F; Ar2 is a benzothiazolyl group; R8 is -CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyriminidyl group and p is 0; R} is -F, -CI, Br, or -I; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyriminidyl group and p is 0; Rt is -F; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration, hi another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyriminidyl group and p is 0; R, is -F, -CI, Br, or -I; Ar2 is a benzothiazolyl group; R9 is -CF3; and R9 is -H, In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyriminidyl group and p is 0; Kx is -F; Ar2 is a benzothiazolyl group; R8 is -CF3; and R9 is -H. In another embodiment, the carbon atom to

which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyriminidyl group and p is 0; R2 is -F, -CI, Br, or -I; Ar2 is a benzothiazolyl group; R9 is -H; and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyriminidyl group and p is 0; R, is -F; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Art is a pyriminidyl group and p is 0; R, is -F, -CI, Br, or -I; Ar2 is a benzothiazolyl group; R9 is -OCH2CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ax{ is a pyriminidyl group and p is 0; R1 is -F; Ar2 is a benzothiazolyl group; R8 is -OCH2CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyriminidyl group and p is 0; R1 is -CH3; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyriminidyl group and p is 0; R1 is -CH3; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -chloro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyriminidyl group and p is 0; R1 is -CH3; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -bromo. In another embodiment, the carbon

itom to which the R3 group is attached has the R configuration. In another embodiment, the :arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyriminidyl group and p is 0; R, is -CH3; Ar2 is a benzothiazolyl group; R8 is -H; and B^ is -fluoro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyriminidyl group and p is 0; R1 is -CH3; Ar2 is a benzothiazolyl group; R8 is -H; and R, is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Art is a pyriminidyl group and p is 0; Rt is -CH3; Ar2 is a benzothiazolyl group; R8 is -halo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyriminidyl group and p is 0; R1 is -CH3; Ar2 is a benzothiazolyl group; R8 is -chloro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar} is a pyriminidyl group and p is 0; R1 is -CH3; Ar2 is a benzothiazolyl group; R8 is -bromo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyriminidyl group and p is 0; R1 is -CH3; Ar2 is a benzothiazolyl group; R9 is -fluoro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyriminidyl group and p is 0; R1 is -CH3; Ar2 is a benzothiazolyl group; R8 is -iodo; and R, is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Aix is a pyriminidyl group and p is 0; R, is -CH3; Ar2 s a benzothiazolyl group; R9 is -H; and R, is -CH3. In another embodiment, the carbon atom o which the R3 group is attached has the R configuration. In another embodiment, the carbon itom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyriminidyl group and p is 0; R, is -CH3; Ar2 s a benzothiazolyl group; R8 is -CH3; and R9 is -H. In another embodiment, the carbon atom ;o which the R3 group is attached has the R configuration. In another embodiment, the carbon itom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyriminidyl group and p is 0; Kx is -CH3; Ar2 is a benzothiazolyl group; R8 is -H; and R> is -CF3, In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axl is a pyriminidyl group and p is 0; R1 is -CH3; Ar2 is a benzothiazolyl group; R8 is -CF3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyriminidyl group and p is 0; R1 is -CH3; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration, hi another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyriminidyl group and p is 0; R1 is -CH3; Ar2 is a benzothiazolyl group; R8 is -OCH2CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ax} is a pyriminidyl group and p is 0; R1 is -CF3; Ar2 is a benzothiazolyl group; and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyriminidyl group and p is 0; R1 is -CF3; Ar2 is a benzothiazolyl group; R8 is -H; and 11$ is -halo. In another embodiment, the carbon atom

to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyriminidyl group and p is 0; Ri is -CF3; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -chloro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyriminidyl group and p is 0; Ri is -CF3; Ar2 is a benzothiazolyl group; Rs is -H; and R» is -bromo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyriminidyl group and p is 0; R, is -CF3; Ar2" is a benzothiazolyl group; R9 is -H; and Rp is -fluoro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyriminidyl group and p is 0; Ri is -CF3; Ar2 is a benzothiazolyl group; Rs is -H; and R9 is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyriminidyl group and p is 0; R, is -CF3; Ar2 is a benzothiazolyl group; R8 is -halo; and 1^ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyriminidyl group and p is 0; R, is -CF3; Ar2 is a benzothiazolyl group; R8 is -chloro; and R» is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyriminidyl group and p is 0; R, is -CF3; Ar2 is a benzothiazolyl group; R8 is -bromo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration, hi another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Ar1 is a pyriminidyl group and p is 0; R9 is -CF3; Ar2 is a benzothiazolyl group; R8 is -fluoro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ax1 is a pyriminidyl group and p is 0; R1 is -CF3; Ar2 is a benzothiazolyl group; R8 is -iodo; and R, is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyriminidyl group and p is 0; R1 is -CF3; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ai} is a pyriminidyl group and p is 0; R1 is -CF3; Ar2 is a benzothiazolyl group; R8 is -CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Art is a pyriminidyl group and p is 0; R2 is -CF3; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ai1 is a pyriminidyl group and p is 0; R1 is -CF3; Ar2 is a benzothiazolyl group; R8 is -CF3; and R> is -EL In another embodiment, the carbon atom to which the R3 group is attached has the R configuration, hi another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyriminidyl group and p is 0; Rr is -CF3; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyriminidyl group and p is 0; R1 is -CF3; Ar2 is a benzothiazolyl group; R8 is -OCH2CH3; and R» is -H. In another embodiment, the carbon

atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyriminidyl group and p is 0; R1 is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -tert-butyl; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyriminidyl group and p is 0; R2 is -F; Ar2 is a benzothiazolyl group; R8 is -tert-butyl; and R» is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyriminidyl group and p is 0; R1 is -F, -CI, -Br, or -I; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -tert-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyriminidyl group and p is 0; R, is -F; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -tert-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar2 is a pyriminidyl group and p is 0; R1 is -CH3; Ar2 is a benzothiazolyl group; R8 is -tert-butyl; and Rp is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Atx is a pyriminidyl group and p is 0; R1 is -CH3; Ar2 is a benzothiazolyl group; R8 is -H; and R9 is -tert-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar2 is a pyriminidyl group and p is 0; R1 is -CH3; Ar2 is a benzothiazolyl group; R8 is -CH3; and R9 is -CH3. In another embodiment, the carbon

atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R1 is -F, -CI, -Br, or -I; R4 is -H; Ar2 is a benzoimidazolyl group; and Rg and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
Li another embodiment, Ar1is a pyridyl group and n is 0; R1 is -F. R4 is -H; Ar2 is a benzoimidazolyl group and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group and n is 0; Kx is -F, -CI -Br, or -I; Ar2 is a benzoimidazolyl group; R9 is -H; and R9 is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group and n is 0; R, is -F, -Cl? -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -chloro., In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyridyl group and n is 0; R1 is -F, -CI -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -bromo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group and n is 0; R1 is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R9 is -H; and R9 is -fluoro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group and n is 0; R1 is -F, -CI -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -H; and B^ is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Ar1is a pyridyl group and n is 0; R1 is -CI; Ax2 is a snzoimidazolyl group; Rs is -H; and R9 is -halo. In another embodiment, the carbon atom to rhich the R3 group is attached has the R configuration. In another embodiment, the carbon torn to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group and n is 0; R1 is -CI; Ar2 is a enzoimidazolyl group; R8 is -H; and R9 is -chloro. In another embodiment, the carbon atom 3 which the R3 group is attached has the R configuration. In another embodiment, the carbon torn to which the R3 group is attached has the S configuration.
la another embodiment, Aix is a pyridyl group and n is 0; Ri is -CI; Ar2 is a >enzoimidazolyl group; R8 is -H; and I^ is -bromo. In another embodiment, the carbon atom o which the R3 group is attached has the R configuration. In another embodiment, the carbon itom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group and n is 0; R1 is -CI; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -fluoro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyridyl group and n is 0; R1 is -CI; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group and n is 0; R1 is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -halo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyridyl group and n is 0; R1 is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -chloro; and 1^ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R1 is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R9 is -bromo; and R9 is -H. In another embodiment, the

carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group and n is 0; R1 is -F, -CI, -Br, or -[; Ar2 is a benzoimidazolyl group; R8 is -fluoro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration, hi another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyridyl group and n is 0; R, is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -iodo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axj is a pyridyl group and n is 0; R1 is -F; Ar2 is a benzoimidazolyl group; R8 is -halo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group and n is 0; R2 is -F; Ar2 is a benzoimidazolyl group; R8 is -chloro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group and n is 0; Rt is -F; Ar2 is a benzoimidazolyl group; R9 is -bromo; and V^ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyridyl group and n is 0; Kx is -F; Ar2 is a benzoimidazolyl group; R9 is -fluoro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group and n is 0; Kx is -F; Ar2 is a benzoimidazolyl group; R8 is -iodo; and JZ$ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Aix is a pyridyl group and n is 0; R5 is -F, -CI, Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -H; and R? is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group and n is 0; R1 is -F; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyridyl group and n is 0; R, is -F, -CI, Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Arl is a pyridyl group and n is 0; R1 is -F; Ar2 is a benzoimidazolyl group; R8 is -CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration, hi another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R, is -F, -CI, Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -H; and 1^ is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyridyl group and n is 0; R, is -F; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group and n is 0; R, is -F, -CI, Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -CF3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group and n is 0; R1 is -F; Ar2 is a benzoimidazolyl group; R8 is -CF3; and 1^ is -H. In another embodiment, the carbon atom to

which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
la another embodiment, Ar1is a pyridyl group and n is 0; R1 is -F, -CI, Br, or -I; Ar2 is a benzoimidazolyl group; R9 is -H; and R» is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group and n is 0; R, is -F; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group and n is 0; R1 is -F, -CI, Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -OCH2CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ai{ is a pyridyl group and n is 0; R, is -F; Ar2 is a benzoimidazolyl group; R8 is -OCH2CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Art is a pyridyl group and n is 0; Ri is -CH3; Ar2 is a benzoimidazolyl group; R8 is -H; and R> is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyridyl group and n is 0; R1 is -CH3; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -chloro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group and n is 0; R, is -CH3; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -bromo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon ) atom to which the R3 group is attached has the S configuration.

In another embodiment, Axx is a pyridyl group and n is 0; K{ is -CH3; Ar2 is a benzoimidazolyl group; R9 is -H; and Rp is -fluoro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyridyl group and n is 0; R! is -CH3; Ar2 is a benzoimidazolyl group; R9 is -H; and R9 is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R1 is -CH3; Ar2 is a benzoimidazolyl group; R& is -halo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar2 is a pyridyl group and n is 0; R1 is -CH3; Ar2 is a benzoimidazolyl group; R8 is -chloro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group and n is 0; R! is -CH3; Ar2 is a benzoimidazolyl group; R9 is -bromo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group and n is 0; R1 is -CH3; Ar2 is a benzoimidazolyl group; R8 is -fluoro; and Rp is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R, is -CH3; Ar2 is a benzoimidazolyl group; R8 is -iodo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R1 is -CH3; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -CH3. In another embodiment, the carbon atom to

vhich the R3 group is attached has the R configuration. In another embodiment, the carbon itom to which the R3 group is attached has the S configuration.
In another embodiment, Ar: is a pyridyl group and n is 0; R1 is -CH3; Ar2 is a >enzoimidazolyl group; Rs is -CH3; and R9 is -H. In another embodiment, the carbon atom to vhich the R3 group is attached has the R configuration. In another embodiment, the carbon itom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyridyl group and n is 0; R1 is -CH3; Ar2 is a Denzoimidazolyl group; R8 is -H; and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group and n is 0; R1 is -CH3; Ar2 is a benzoimidazolyl group; R8 is -CF3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group and n is 0; Kx is -CH3; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyridyl group and n is 0; R1 is -CH3; Ar2 is a benzoimidazolyl group; R8 is -OCH2CH3; and B^ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. Jn another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; Rt is -CF3; Ar2 is a benzoimidazolyl group; and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group and n is 0; R, is -CF3; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, AT, is a pyridyl group and n is 0; R, is -CF3; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -chloro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
hi another embodiment, Axx is a pyridyl group and n is 0; R, is -CF3; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -bromo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration, in another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group and n is 0; R, is ~CF3; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -fluoro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R{ is -CF3; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R2 is -CF3; Ar2 is a benzoimidazolyl group; R9 is -halo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
hi another embodiment, AR1 is a pyridyl group and n is 0; R1 is -CF3; Ar2 is a benzoimidazolyl group; R8 is -chloro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group and n is 0; R2 is -CF3; Ar2 is a benzoimidazolyl group; R8 is -bromo; and R, is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R1 is -CF3; Ar2 is a benzoimidazolyl group; R8 is -fluoro; and R, is -H. In another embodiment, the carbon atom

;o which the R3 group is attached has the R configuration. In another embodiment, the carbon itom to which the R3 group is attached has the S configuration.
In another embodiment, Ar{ is a pyridyl group and n is 0; Ra is -CF3; Ar2 is a benzoimidazolyl group; R9 is -iodo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group and n is 0; R1 is -CF3; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group and n is 0; R1 is -CF3; Ar2 is a benzoimidazolyl group; R8 is -CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R1 is -CF3; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group and n is 0; R, is -CF3; Ar2 is a benzoimidazolyl group; R8 is -CF3; and R9 is -H. hi another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyridyl group and n is 0; R, is -CF3; Ar2 is a benzoimidazolyl group; R8 is -H; and R, is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group and n is 0; R1 is -CF3; Ar2 is a benzoimidazolyl group; R8 is -OCH2CH3; and R9 is -H. Li another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Ar1is a pyridyl group and n is 0; Rr is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -tert-bxxtyl; and R, is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyridyl group and n is 0; R1 is -F; Ar2 is a benzoimidazolyl group; R8 is -terf-butyl; and R, is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration, hi another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axl is a pyridyl group and n is 0; R1 is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R9 is -H; and R9 is -terf-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R, is -F; Ar2 is a benzoimidazolyl group; R8 is -H; and R» is -fertf-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axt is a pyridyl group and n is 0; R1 is -CH3; Ar2 is a benzoimidazolyl group; R8 is -/erf-butyl; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group and n is 0; R, is -CH3; Ar2 is a benzoimidazolyl group; R8 is -H; and R, is -tert~buty\. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group and n is 0; R, is -CH3; Ar2 is a benzoimidazolyl group; R9 is -CH3; and K^ is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyriminidyl group and p is 0; R, is -F, -CI, -Br, or -I; R4 is -H; Ar2 is a benzoimidazolyl group; and R8 and Rg are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In

another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyriminidyl group and p is 0; Rl is -F. R4 is -H; Ar2 is a benzoimidazolyl group and R8 and B^ are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyriminidyl group and p is 0; R1 is -F, -CI -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -halo, hi another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
hi another embodiment, AR1 is a pyriminidyl group and p is 0; R1 is -F, -Cl^ -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -chloro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyriminidyl group and p is 0; R1 is -F, -Clf -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -H; and R, is -bromo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
hi another embodiment, Ar1 is a pyriminidyl group and p is 0; R1 is -F, -CI -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -fiuoro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar{ is a pyriminidyl group and p is 0; R1 is -F, -CI -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -iodo. hi another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyriminidyl group and p is 0; R1 is -CI; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Axx is a pyriminidyl group and p is 0; R1 is -CI; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -chloro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar2 is a pyriminidyl group and p is 0; R1 is -CI; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -bromo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyriminidyl group and p is 0; Rt is -CI; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -fluoro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyriminidyl group and p is 0; R1 is -CI; Ar2 is a benzoimidazolyl group; R9 is -H; and R9 is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyriminidyl group and p is 0; R, is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -halo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyriminidyl group and p is 0; R1 is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -chloro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyriminidyl group and p is 0; R1 is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -bromo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyriminidyl group and p is 0; R1 is -F, -CI, - Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -fluoro; and R9 is -H. In another embodiment,

tie carbon atom to which the R3 group is attached has me K conngurauon. in anomcr mbodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyriminidyl group and p is 0; R, is -F, -CI, -3r, or -I; Ar2 is a benzoimidazolyl group; R8 is -iodo; and R9 is -H. In another embodiment, he carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyriminidyl group and p is 0; R1 is -F; Ar2 is a. benzoimidazolyl group; R8 is -halo; and R, is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyriminidyl group and p is 0; R1 is -F; Ar2 is a benzoimidazolyl group; R8 is -chloro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyriminidyl group and p is 0; R1 is -F; Ar2 is a benzoimidazolyl group; R8 is -bromo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyriminidyl group and p is 0; R1 is -F; Ar2 is a benzoimidazolyl group; R8 is -fluoro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar2 is a pyriminidyl group and p is 0; R, is -F; Ar2 is a benzoimidazolyl group; R8 is -iodo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
Li another embodiment, Ar1is a pyriminidyl group and p is 0; R1 is -F, -CI, Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, AR1 is a pyriminidyl group and p is 0; R1 is -F; Ar2 is a benzoimidazolyl group; R8 is -H; and R? is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyriminidyl group and p is 0; R1 is -F, -CI, Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Arl is a pyriminidyl group and p is 0; R1 is -F; Ar2 is a benzoimidazolyl group; R8 is -CH3; and R? is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyriminidyl group and p is 0; R1 is -F, -CI, Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyriminidyl group and p is 0; R1 is -F; Ar2 is a benzoimidazolyl group; R9 is -H; and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon l atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyriminidyl group and p is 0; R1 is -F, -CI, Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -CF3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyriminidyl group and p is 0; R, is -F; Ar2 is a benzoimidazolyl group; R8 is -CF3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyriminidyl group and p is 0; R1 is -F, -CI, Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In

mother embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyriminidyl group and p is 0; R1 is -F; Ar2 is a benzohnidazolyl group; R8 is -H; and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyriminidyl group and p is 0; R1 is -F, -CI, Br, or -I; Ar2 is a benzohnidazolyl group; R8 is -OCH2CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyriminidyl group and p is 0; R1 is -F; Ar2 is a benzohnidazolyl group; R8 is -OCH2CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyriminidyl group and p is 0; ^ is -CH3; Ar2 is a benzohnidazolyl group; R8 is -H; and R9 is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyriminidyl group and p is 0; R1 is -CH3; Ar2 is a benzohnidazolyl group; R8 is -H; and R9 is -chloro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Art is a pyriminidyl group and p is 0; R1 is -CH3; Ar2 is a benzohnidazolyl group; R8 is -H; and R9 is -bromo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyriminidyl group and p is 0; R1 is -CH3; Ar2 is a benzohnidazolyl group; R8 is -H; and R9 is -fluoro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Ar1 is a pyriminidyl group and p is 0; R, is -CH3; Ar2 a benzoimidazolyl group; R8 is -H; and R9 is -iodo. In another embodiment, the carbon om to which the R3 group is attached has the R configuration. In another embodiment, the irbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyriminidyl group and p is 0; R, is -CH3; Ar2 a benzoimidazolyl group; R8 is -halo; and R9 is -H. In another embodiment, the carbon :om to which the R3 group is attached has the R configuration. In another embodiment, the arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyriminidyl group and p is 0; R1 is -CH3; Ar2 5 a benzoimidazolyl group; R8 is -chloro; and R9 is -H. In another embodiment, the carbon torn to which the R3 group is attached has the R configuration. In another embodiment, the arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyriminidyl group and p is 0; R1 is -CH3; Ar2 s a benzoimidazolyl group; R8 is -bromo; and R9 is -H. hi another embodiment, the carbon itom to which the R3 group is attached has the R configuration. In another embodiment, the ;arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyriminidyl group and p is 0; R1 is -CH3; Ar2 is a benzoimidazolyl group; R8 is -fluoro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyriminidyl group and p is 0; Kx is -CH3; Ar2 is a benzoimidazolyl group; R8 is -iodo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyriminidyl group and p is 0; R1 is -CH3; Ar2 is a benzoimidazolyl group; R8 is -H; and R, is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyriminidyl group and p is 0; R1 is -CH3; Ar2 is a benzoimidazolyl group; R8 is -CH3; and R9 is -H. In another embodiment, the carbon

om to which the R3 group is attached has the R configuration. In another embodiment, the irbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Art is a pyriminidyl group and p is 0; R1 is -CH3; Ar2 \ a benzoimidazolyl group; R8 is -H; and R9 is -CF3. In another embodiment, the carbon torn to which the R3 group is attached has the R configuration. In another embodiment, the arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyriminidyl group and p is 0; Kx is -CH3; Ar2 s a benzoimidazolyl group; R8 is -CF3; and Rp is -H. In another embodiment, the carbon ttom to which the R3 group is attached has the R configuration. In another embodiment, the :arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyriminidyl group and p is 0; Rt is CH3; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyriminidyl group and p is 0; R1 is -CH3; Ar2 is a benzoimidazolyl group; R9 is -OCH2CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar} is a pyriminidyl group and p is 0; R, is -CF3; Ar2 is a benzoimidazolyl group; and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyriminidyl group and p is 0; R, is -CF3; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axl is a pyriminidyl group and p is 0; R1 is -CF3; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -chloro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the ) carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Aix is a pyriminidyl group and p is 0; RI is -CF3; Ar2 > a benzoimidazolyl group; R8 is -H; and R9 is -bromo. In another embodiment, the carbon torn to which the R3 group is attached has the R configuration. In another embodiment, the arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyriminidyl group and p is 0; R, is -CF3; Ar2 s a benzoimidazolyl group; R8 is -H; and R9 is -fluoro. hi another embodiment, the carbon ttom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar5 is a pyriminidyl group and p is 0; Rt is -CF3; Ar2 s a benzoimidazolyl group; R8 is -H; and R9 is -iodo. In another embodiment, the carbon itom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration,
In another embodiment, Axx is a pyriminidyl group and p is 0; R1 is -CF3; Ar2 is a benzoimidazolyl group; R8 is -halo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyriminidyl group and p is 0; R1 is -CF3; Ar2 is a benzoimidazolyl group; R9 is -chloro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyriminidyl group and p is 0; R, is -CF3; Ar2 is a benzoimidazolyl group; R8 is -bromo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyriminidyl group and p is 0; R1 is -CF3; Ar2 is a benzoimidazolyl group; R9 is -fluoro; and 1^ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyriminidyl group and p is 0; R1 is -CF3; Ar2 is a benzoimidazolyl group; R8 is -iodo; and R> is -H. In another embodiment, the carbon

itom to which the R3 group is attached has the R configuration. In another embodiment, the ;arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyriminidyl group and p is 0; Ri is -CF3; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Art is a pyriminidyl group and p is 0; R1 is -CF3; Ar2 is a benzoimidazolyl group; R8 is -CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyriminidyl group and p is 0; R, is -CF3; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration. .
In another embodiment, Axx is a pyriminidyl group and p is 0; R1 is -CF3; Ar2 is a benzoimidazolyl group; R8 is -CF3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyriminidyl group and p is 0; R1 is -CF3; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyriminidyl group and p is 0; R, is -CF3; Ar2 is a benzoimidazolyl group; R9 is -OCH2CH3; and B^ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyriminidyl group and p is 0; R1 is -F, -CI, -Br, or -I; Ar2 is a benzoimidazolyl group; R8 is -ferf-butyl; and R» is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Art is a pyriminidyl group and p is 0; R1 is -F; Ar2 is benzoimidazolyl group; R8 is -tort-butyl; and R, is -H. In another embodiment, the carbon torn to which the R3 group is attached has the R configuration. In another embodiment, the arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyriminidyl group and p is 0; Rr is -F, -CI, -Jr, or -I; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -tort-butyl. In another mbodiment, the carbon atom to which the R3 group is attached has the R configuration. In mother embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyriminidyl group and p is 0; R1 is -F; Ar2 is i benzoimidazolyl group; R8 is -H; and R9 is -tort-butyl. In another embodiment, the carbon itom to which the R3 group is attached has the R configuration. In another embodiment, the :arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyriminidyl group and p is 0; Kx is -CH3; Ar2 is a benzoimidazolyl group; R9 is -tort-butyl; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyriminidyl group and p is 0; R{ is -CH3; Ar2 is a benzoimidazolyl group; R8 is -H; and R9 is -tort-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyriminidyl group and p is 0; Kx is -CH3; Ar2 is a benzoimidazolyl group; R8 is -CH3; and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyridyl group and n is 0; R1 is -F, -CI, -Br, or -I; R4 is -H; Ar2 is a benzooxazolyl group; and R8 and Rg are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyridyl group and n is 0; R1 is -F. R4 is -H; Ar2 is a benzooxazolyl group and R8 and R9 are -H. In another embodiment, the carbon atom to

rtiich the R3 group is attached has the R configuration. In another embodiment, the carbon torn to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R, is -F, -Q -Br, or -; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -halo. In another embodiment, the carbon itom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R, is -F, -Cl( -Br, or -\\ Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -chloro. In another embodiment, the :arbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R, is -F, -CI -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -bromo. hi another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; Rt is -F, -CI -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -H; and B^ is -fluoro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R, is -F, -CI -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R, is -CI; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R, is -CI; Ar2 is a benzooxazolyl group; R8 is -H; and ^ is -chloro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Ar1is a pyridyl group and n is 0; R1 is -CI; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -bromo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyridyl group and n is 0; R1 is -CI; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -fluoro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R, is -CI; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group arid n is 0; R, is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R9 is -halo; and 11$ is -H. hi another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group and n is 0; R9 is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -chloro; and R9 is -H.
In another embodiment, Art is a pyridyl group and n is 0; Kx is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -bromo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group and n is 0; R, is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -fluoro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R1 is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -iodo; and ^ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Ai\ is a pyridyl group and n is 0; R1 is -F; Ar2 is a jnzooxazolyl group; R8 is -halo; and R9 is -H. In another embodiment, the carbon atom to hich the R3 group is attached has the R configuration. In another embodiment, the carbon om to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group and n is 0; Kx is -F; Ar2 is a snzooxazolyl group; R8 is -chloro; and R9 is -H. In another embodiment, the carbon atom to hich the R3 group is attached has the R configuration. In another embodiment, the carbon torn to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group and n is 0; R1 is -F; Ar2 is a enzooxazolyl group; R8 is -bromo; and R9 is -H. In another embodiment, the carbon atom to rtiich the R3 group is attached has the R configuration. In another embodiment, the carbon torn to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group and n is 0; R: is -F; Ar2 is a ►enzooxazolyl group; R8 is -fluoro; and R9 is -H. In another embodiment, the carbon atom to vhich the R3 group is attached has the R configuration. In another embodiment, the carbon itom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group and n is 0; R1 is -F; Ar2 is a benzooxazolyl group; R9 is -iodo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group and n is 0; R1 is -F, -CI, Br, or -[; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyridyl group and n is 0; R1 is -F; Ar2 is a benzooxazolyl group; R9 is -H; and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Art is a pyridyl group and n is 0; R1 is -F, -CI, Br, or -I; Ar2 is a benzooxazolyl group; R9 is -CH3; and R9 is -H. In another embodiment, the carbon

atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Arl is a pyridyl group and n is 0; R1 is -F; Ar2 is a benzooxazolyl group; R8 is -CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ax{ is a pyridyl group and n is 0; R, is -F, -CI, Br, or -I; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group and n is 0; R, is -F; Ar2 is a benzooxazolyl group; R8 is -H; and ^ is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; Rt is -F, -CI, Br, or -I; Ar2 is a benzooxazolyl group; R8 is -CF3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R, is -F; Ar2 is a benzooxazolyl group; R8 is -CF3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group and n is 0; R1 is -F, -CI, Br, or -I; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyridyl group and n is 0; R1 is -F; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Ar1is a pyridyl group and n is 0; R, is -F, -CI, Br, or -I; Ar2 is a benzooxazolyl group; R8 is -OCH2CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Art is a pyridyl group and n is 0; R1 is -F; Ar2 is a benzooxazolyl group; R8 is -OCH2CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group and n is 0; R1 is -CH3; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group and n is 0; Ra is -CH3; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -chloro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R, is -CH3; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -bromo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R1 is -CH3; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -fluoro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group and n is 0; R, is -CH3; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ai} is a pyridyl group and n is 0; R1 is -CH3; Ar2 is a benzooxazolyl group; R8 is -halo; and R> is -H. In another embodiment, the carbon atom to

which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R, is -CH3; Ar2 is a benzooxazolyl group; R8 is -chloro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R, is -CH3; Ar2 is a benzooxazolyl group; R8 is -bromo; and 1^ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R, is -CH3; Ar2 is a benzooxazolyl group; R8 is -fluoro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R, is -CH3; Ar2 is a benzooxazolyl group; R8 is -iodo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R, is -CH3; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R, is -CH3; Ar2 is a benzooxazolyl group; Rs is -CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R, is -CH3; Ar2 is a benzooxazolyl group; R9 is -H; and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Ar1is a pyridyl group and n is 0; R, is -CH3; Ar2 is a benzooxazolyl group; R8 is -CF3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R, is -CH3; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R1 is -CH3; Ar2 is a benzooxazolyl group; R8 is -OCH2CH3; and ^ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R, is -CF3; Ar2 is a benzooxazolyl group; and R8 and 0$ are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R, is -CF3; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R, is -CF3; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -chloro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R, is -CF3; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -bromo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R, is -CF3; Ar2 is a benzooxazolyl group; R8 is -H; and 1^ is -fluoro. In another embodiment, the carbon atom to

which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group and n is 0; R1 is -CF3; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -iodo. In another embodiment, the carbon atom to I which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R1 is -CF3; Ar2 is a benzooxazolyl group; R8 is -halo; and ^ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon • atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R2 is -CF3; Ar2 is a benzooxazolyl group; R9 is -chloro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group and n is 0; Rt is -CF3; Ar2 is a benzooxazolyl group; R8 is -bromo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyridyl group and n is 0; R1 is -CF3; Ar2 is a benzooxazolyl group; R8 is -fluoro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R1 is -CF3; Ar2 is a benzooxazolyl group; R9 is -iodo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R, is -CF3; Ar2 is a benzooxazolyl group; R8 is -H; and R1 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Ar1is a pyridyl group and n is 0; R, is -CF3; Ar2 is a enzooxazolyl group; R8 is -CH3; and R9 is -H. In another embodiment, the carbon atom to /hich the R3 group is attached has the R configuration. In another embodiment, the carbon torn to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R1 is -CF3; Ar2 is a >enzooxazolyl group; R9 is -H; and R> is -CF3. In another embodiment, the carbon atom to vhich the R3 group is attached has the R configuration. In another embodiment, the carbon itom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R, is -CF3; Ar2 is a senzooxazolyl group; R8 is -CF3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R, is -CF3; Ar2 is a benzooxazolyl group; R8 is -H; and 1^ is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; Rl is -CF3; Ar2 is a benzooxazolyl group; R8 is -OCH2CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R, is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -terf-butyl; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R, is -F; Ar2 is a benzooxazolyl group; Rs is -tert-butyl; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyridyl group and n is 0; R, is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -terf-butyl. In another embodiment, the

carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyridyl group and n is 0; R1 is -F; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -terf-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyridyl group and n is 0; R{ is -CH3; Ar2 is a benzooxazolyl group; R8 is -fert»butyl; and RQ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyridyl group and n is 0; R1 is -CH3; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -tert-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
hi another embodiment, Aix is a pyridyl group and n is 0; R1 is -CH3; Ar2 is a benzooxazolyl group; R8 is -CH3; and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ai{ is a pyriminidyl group and p is 0; R! is -F, -CI, -Br, or -I; R4 is -H; Ar2 is a benzooxazolyl group; and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyriminidyl group and p is 0; R{ is -F. R4 is -H; Ar2 is a benzooxazolyl group and R8 and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyriminidyl group and p is 0; R, is -F, -Clf -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -H; and Re, is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, AR1 is a pyriminidyl group and p is 0; Kx is -F, -CI -ir, or -I; Ar2 is a benzooxazolyl group; R9 is -H; and B^ is -chloro. In another embodiment, le carbon atom to which the R3 group is attached has the R configuration. In another mbodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyriminidyl group and p is 0; R, is -F, -CI -Jr, or -I; Ar2 is a benzooxazolyl group; R9 is -H; and R9 is -bromo. In another embodiment, lie carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyriminidyl group and p is 0; Kx is -F, -CI -3r, or -I; Ar2 is a benzooxazolyl group; R9 is -H; and R9 is -fluoro. In another embodiment, he carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyriminidyl group and p is 0; Kx is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Art is a pyriminidyl group and p is 0; Kx is -CI; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyriminidyl group and p is 0; Rt is -CI; Ar2 is a benzooxazolyl group; R9 is -H; and R9 is -chloro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyriminidyl group and p is 0; R1 is -CI; Ar2 is a benzooxazolyl group; Rs is -H; and R9 is -bromo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyriminidyl group and p is 0; R1 is -CI; Ar2 is a benzooxazolyl group; R8 is -H; and Rs is -fluoro. In another embodiment, the carbon atom

to whifch the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyriminidyl group and p is 0; R, is -CI; Ar2 is a benzooxazolyl group; R8 is -H; and R» is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyriminidyl group and p is 0; R, is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -halo; and R? is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyriminidyl group and p is 0; R, is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -chloro; and 11$ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyriminidyl group and p is 0; R, is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -bromo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyriminidyl group and p is 0; R1 is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -fluoro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyriminidyl group and p is 0; R, is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -iodo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyriminidyl group and p is 0; R, is -F; Ar2 is a benzooxazolyl group; R8 is -halo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon ► atom to which the R3 group is attached has the S configuration.

In another embodiment, AR1 is a pyriminidyl group and p is 0; Kx is -F; Ar2 is L benzooxazolyl group; R8 is -chloro; and ^ is -H. In another embodiment, the carbon atom o which the R3 group is attached has the R configuration. In another embodiment, the carbon itoni to which theR3 group is attached has the S configuration.
In another embodiment, Axx is a pyriminidyl group and p is 0; R! is -F; Ar2 is i benzooxazolyl group; R8 is -bromo; and R9 is -H. In another embodiment, the carbon atom ;o which the R3 group is attached has the R configuration. In another embodiment, the carbon itom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyriminidyl group and p is 0; R{ is -F; Ar2 is a benzooxazolyl group; R8 is -fluoro; and B^ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyriminidyl group and p is 0; R, is -F; Ar2 is a benzooxazolyl group; R8 is -iodo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ax} is a pyriminidyl group and p is 0; R1 is -F, -CI, Br, or -I; Ar2 is a benzooxazolyl group; R8 is -H; and B^ is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyriminidyl group and p is 0; R1 is -F; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ax} is a pyriminidyl group and p is 0; R1 is -F, -CI, Br, or -I; Ar2 is a benzooxazolyl group; R8 is -CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Arl is a pyriminidyl group and p is 0; R1 is -F; Ar2 is a benzooxazolyl group; R8 is -CH3; and R9 is -H. In another embodiment, the carbon atom to

ich the R3 group is attached has the R configuration. In another embodiment, the carbon tn to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyriminidyl group and p is 0; R1 is -F, -CI, or -I; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -CF3. In another embodiment, the bon atom to which the R3 group is attached has the R configuration. In another Lbodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyriminidyl group and p is 0; Rt is -F; Ar2 is >enzooxazolyl group; R8 is -H; and R9 is -CF3. In another embodiment, the carbon atom to lich the R3 group is attached has the R configuration. In another embodiment, the carbon Dm to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyriminidyl group and p is 0; R1 is -F, -CI, r, or -I; Ar2 is a benzooxazolyl group; R9 is -CF3; and R9 is -H. In another embodiment, the irbon atom to which the R3 group is attached has the R configuration. In another nbodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ax} is a pyriminidyl group and p is 0; R1 is -F; Ar2 is benzooxazolyl group; R8 is -CF3; and R9 is -H. In another embodiment, the carbon atom to tfrich the R3 group is attached has the R configuration. In another embodiment, the carbon torn to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyriminidyl group and p is 0; Kx is -F, -CI, Jr, or -I; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -OGH2CH3. In another mbodiment, the carbon atom to which the R3 group is attached has the R configuration. In mother embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyriminidyl group and p is 0; Rt is -F; Ar2 is i benzooxazolyl group; R8 is -H; and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyriminidyl group and p is 0; R1 is -F, -CI, Br, or -I; Ar2 is a benzooxazolyl group; R8 is -OCH2CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In

another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ax{ is a pyriminidyl group and p is 0; R} is -F; Ar2 is a benzooxazolyl group; R8 is -OCH2CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyriminidyl group and p is 0; R1 is -CH3; Ar2 is a benzooxazolyl group; R9 is -H; and R9 is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar} is a pyriminidyl group and p is 0; R1 is -CH3; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -chloro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyriminidyl group and p is 0; R1 is -CH3; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -bromo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Art is a pyriminidyl group and p is 0; R1 is -CH3; Ar2 is a benzooxazolyl group; R9 is -H; and R9 is -fluoro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyriminidyl group and p is 0; R1 is -CH3; Ar2 is a benzooxazolyl group; R8 is -H; and R? is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyriminidyl group and p is 0; R1 is -CH3; Ar2 is a benzooxazolyl group; R8 is -halo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Axx is a pyriminidyl group and p is 0; R1 is -CH3; Ar2 is a benzooxazolyl group; R8 is -chloro; and R9 is -H. In another embodiment, the carbon itom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyriminidyl group and p is 0; K} is -CH3; Ar2 is a benzooxazolyl group; R9 is -bromo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyriminidyl group and p is 0; Rt is -CH3; Ar2 is a benzooxazolyl group; R8 is -fluoro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ara is a pyriminidyl group and p is 0; R1 is -CH3; Ar2 is a benzooxazolyl group; R8 is -iodo; and 1^ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyriminidyl group and p is 0; RT is -CH3; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyriminidyl group and p is 0; R1 is -CH3; Ar2 is a benzooxazolyl group; R8 is -CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyriminidyl group and p is 0; R1 is -CH3; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar2 is a pyriminidyl group and p is 0; Rl is -CH3; Ar2 is a benzooxazolyl group; R8 is -CF3; and Rp is -H. In another embodiment, the carbon atom

which the R3 group is attached has the R configuration. In another embodiment, the carbon om to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyriminidyl group and p is 0; RY is -CH3; Ar2 ; a benzooxazolyl group; R8 is -H; and R9 is -OCH2CH3. In another embodiment, the carbon torn to which the R3 group is attached has the R configuration. In another embodiment, the arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyriminidyl group and p is 0; Kx is -CH3; Ar2 s a benzooxazolyl group; R8 is -OCH2CH3; and R, is -H. In another embodiment, the carbon torn to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyriminidyl group and p is 0; R1 is -CF3; Ar2" s a benzooxazolyl group; and Rg and R9 are -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyriminidyl group and p is 0; Rt is -CF3; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -halo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyriminidyl group and p is 0; Kx is -CF3; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -chloro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyriminidyl group and p is 0; R1 is -CF3; Ar2 is a benzooxazolyl group; R8 is -H; and Rp is -bromo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyriminidyl group and p is 0; R1 is -CF3; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -fluoro. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.

In another embodiment, Aix is a pyriminidyl group and p is 0; R1 is -CF3; Ar2 is a benzooxazolyl group; R8 is -H; and R, is -iodo. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Art is a pyriminidyl group and p is 0; R1 is -CF3; Ar2 is a benzooxazolyl group; R8 is -halo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyriminidyl group and p is 0; R1 is -CF3; Ar2 is a benzooxazolyl group; R8 is -chloro; and R? is -H, In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyriminidyl group and p is 0; R1 is -CF3; Ar2 is a benzooxazolyl group; Rs is -bromo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyriminidyl group and p is 0; R1 is -CF3; Ar2 is a benzooxazolyl group; R8 is -fluoro; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Art is a pyriminidyl group and p is 0; R1 is -CF3; Ar2 is a benzooxazolyl group; R8 is -iodo; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyriminidyl group and p is 0; R1 is -CF3; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyriminidyl group and p is 0; R1 is -CF3; Ar2 ) is a benzooxazolyl group; R8 is -CH3; and R9 is -H. In another embodiment, the carbon atom

to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyriminidyl group and p is 0; R1 is -CF3; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -CF3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Aix is a pyriminidyl group and p is 0; R{ is -CF3; Ar2 is a benzooxazolyl group; R8 is -CF3; and 1^ is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ai} is a pyriminidyl group and p is 0; Rl is -CF3; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -OCH2CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyriminidyl group and p is 0; R! is -CF3; Ar2 is a benzooxazolyl group; R8 is -OCH2CH3; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar} is a pyriminidyl group and p is 0; R1 is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R8 is -tert-butyl; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1 is a pyriminidyl group and p is 0; R{ is -F; Ar2 is a benzooxazolyl group; R8 is -terf-butyl; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Ar1is a pyriminidyl group and p is 0; R, is -F, -CI, -Br, or -I; Ar2 is a benzooxazolyl group; R9 is -H; and R9 is -tert-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In

nother embodiment, the carbon atom to which the R3 group is attached has the S onfiguration.
In another embodiment, Ar1 is a pyriminidyl group and p is 0; R, is -F; Ar2 is L benzooxazolyl group; R8 is -H; and R9 is -terf-butyl. In another embodiment, the carbon torn to which the R3 group is attached has the R configuration. In another embodiment, the ;arbon atom to which the R3 group is attached has the S configuration.
In another embodiment, Axx is a pyriminidyl group and p is 0; R1 is -CH3; Ar2 s a benzooxazolyl group; R8 is -tert-butyl; and R9 is -H. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the :arbon atom to which the R3 group is attached has the S configuration.
Li another embodiment, Ai} is a pyriminidyl group and p is 0; R1 is -CH3; Ar2 is a benzooxazolyl group; R8 is -H; and R9 is -terf-butyl. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In another embodiment, AR1 is a pyriminidyl group, p is 0; Rt is -CH3; Ar2 is a benzooxazolyl group; R8 is -CH3; and R1 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
hi another embodiment, Aix is a pyriminidyl group, p is 0; R, is -CH3; Ar2 is a benzooxazolyl group; R9 is -CH3; and R9 is -CH3. In another embodiment, the carbon atom to which the R3 group is attached has the R configuration. In another embodiment, the carbon atom to which the R3 group is attached has the S configuration.
In the Benzoazolylpiperazine Compounds the R3 group can be on any carbon of the piperazine ring. In one embodiment, the R3 group is attached to a carbon atom adjacent to the nitrogen atom attached to the pyridyl group, pyrimidinyl group, pyrazinyl group, pyridazinyl group, or thiazanyl group. In another embodiment, the R3 group is attached to a carbon atom adjacent to the nitrogen atom attached to the -(A)- group, when x is 1; or the R3 group is attached to the carbon atom adjacent to the nitrogen atom attached to the benzothiazolyl group, the benzoimidazolyl group, or the benzooxazolyl group, when x is 0.
In one embodiment, wherein the Benzoazolylpiperazine Compound has an R3 group, the carbon atom to which the R3 group is attached has the (R) configuration. In

another embodiment, wherein the Benzoazolylpiperazine Compound has an R3 group, the carbon atom to which the R3 group is attached has the (S) configuration.
In another embodiment, the Benzoazolylpiperazine Compound has an R3 group; the R3 group is attached to a carbon atom adjacent to a nitrogen atom attached to the pyridyl group, pyrimidinyl group, pyrazinyl group, pyridazinyl group, or thiazanyl group; and the carbon to which the R3 group is attached is in the (R) configuration. In another embodiment, the Benzoazolylpiperazine Compound has an R3 group; the R3 group is attached to a carbon atom adjacent to a nitrogen attached to the pyridyl group, pyrimidinyl group, pyrazinyl group, pyridazinyl group, or thiazanyl group; the carbon to which the R3 group is attached is in the (R) configuration; and R3 is -(CrC4)alkyl unsubstituted or substituted with one or more halo groups. In another embodiment, the Benzoazolylpiperazine Compound has an R3 group; the R3 group is attached to a carbon atom adjacent to a nitrogen attached to the pyridyl group, pyrimidinyl group, pyrazinyl group, pyridazinyl group, or thiazanyl group; the carbon to which the R3 group is attached is in the (R) configuration; and R3 is CH3. In another embodiment, the Benzoazolylpiperazine Compound has an R3 group; the R3 group is attached to a carbon atom adjacent to a nitrogen attached to the pyridyl group, pyrimidinyl group, pyrazinyl group, pyridazinyl group, or thiazanyl group; the carbon to which the R3 group is attached is in the (R) configuration; and R3 is -CF3. In another embodiment, the Benzoazolylpiperazine Compound has an R3 group; the R3 group is attached to a carbon atom adjacent to a nitrogen attached to the pyridyl group, pyrimidinyl group, pyrazinyl group, pyridazinyl group, or thiazanyl group; the carbon to which the R3 group is attached is in the (R) configuration; and R3 is -CH2CH3.
In another embodiment, the Benzoazolylpiperazine Compound has an R3 group; the R3 group is attached to a carbon atom adjacent to a nitrogen atom attached to the -(A)- group, when x is 1; or the R3 group is attached to the carbon atom adjacent to the nitrogen atom attached to the benzothiazolyl group, the benzoimidazolyl group, or the benzooxazolyl group when x is 0; and the carbon to which the R3 group is attached is in the (R) configuration. In another embodiment, the Benzoazolylpiperazine Compound has an R3 group; the R3 group is attached to a carbon atom adjacent to a nitrogen attached to the -(A)-group, when x is 1; or the R3 group is attached to the carbon atom adjacent to the nitrogen atom attached to the benzothiazolyl group, the benzoimidazolyl group, or the benzooxazolyl

roup, when x is 0; the carbon to which the R3 group is attached is in the (R) configuration; nd R3 is -(CrC4)alkyl unsubstituted or substituted with one or more halo groups. In another anbodiment, the Benzoazolylpiperazine Compound has an R3 group; the R3 group is ttached to a carbon atom adjacent to a nitrogen attached to the -(A)- group, when x is 1; or lie R3 group is attached to the carbon atom adjacent to the nitrogen atom attached to the lenzothiazolyl group, the benzoimidazolyl group, or the benzooxazolyl group when x is 0; he carbon to which the R3 group is attached is in the (R) configuration; and R3 is -CH3. In mother embodiment, the Benzoazolylpiperazine Compound has an R3 group; the R3 group is attached to a carbon atom adjacent to a nitrogen attached to the -(A)- group, when x is 1; or he R3 group is attached to the carbon atom adjacent to the nitrogen atom attached to the t>enzothiazolyl group, the benzoimidazolyl group, or the benzooxazolyl group, when x is 0; the carbon to which the R3 group is attached is in the (R) configuration; and R3 is -CF3. In another embodiment, the Benzoazolylpiperazine Compound has an R3 group; the R3 group is attached to a carbon atom adjacent to a nitrogen attached to the -(A)- group, when x is 1; or the R3 group is attached to the carbon atom adjacent to the nitrogen atom attached to the benzothiazolyl group, the benzoimidazolyl group, or the benzooxazolyl group, when x is 0; the carbon to which the R3 group is attached is in the (R) configuration; and R3 is -CH2CH3,
In another embodiment, the Benzoazolylpiperazine Compound has an R3
group; the R3 group is attached to a carbon atom adjacent to a nitrogen atom attached to the
pyridyl group, pyrimidinyl group, pyrazinyl group, pyridazinyl group, or thiazanyl group; and
the carbon to which the R3 group is attached is in the (S) configuration. In another
embodiment, the Benzoazolylpiperazine Compound has an R3 group; the R3 group is attached
to a carbon atom adjacent to a nitrogen attached to the pyridyl group, pyrimidinyl group,
pyrazinyl group, pyridazinyl group, or thiazanyl group; the carbon to which the R3 group is
attached is in the (S) configuration; and R3 is -(C,-C4)alkyl unsubstituted or substituted with
one or more halo groups. In another embodiment, the Benzoazolylpiperazine Compound has
an R3 group; the R3 group is attached to a carbon atom adjacent to a nitrogen attached to the
pyridyl group, pyrimidinyl group, pyrazinyl group, pyridazinyl group, or thiazanyl group; the
carbon to which the R3 group is attached is in the (S) configuration; and R3 is -CH3. In
another embodiment, the Benzoazolylpiperazine Compound has an R3 group; the R3 group is
attached to a carbon atom adjai— u—~~~ ^U^^U^A +/% Uf Twririvi omnn. nvrimidinvl

group, pyrazinyl group, pyridazinyl group, or thiazanyl group; the carbon to which the R3 group is attached is in the (S) configuration; and R3 is -CF3. In another embodiment, the Benzoazolylpiperazine Compound has an R3 group; the R3 group is attached to a carbon atom adjacent to a nitrogen attached to the pyridyl group, pyrimidinyl group, pyrazinyl group, pyridazinyl group, or thiazanyl group; the carbon to which the R3 group is attached is in the (S) configuration; and R3 is -CH2CH3.
In another embodiment, the Benzoazolylpiperazine Compound has an R3 groups; the R3 group is attached to a carbon atom adjacent to a nitrogen atom attached to the -(A)- group, when x is 1; or the R3 group is attached to the carbon atom adjacent to the nitrogen atom attached to the benzothiazolyl group, the benzoimidazolyl group, or the benzooxazolyl group, when x is 0; and the carbon to which the R3 group is attached is in the (S) configuration. In another embodiment, the Benzoazolylpiperazine Compound has an R3 group; the R3 group is attached to a carbon atom adjacent to a nitrogen attached to the -(A)-group, when x is 1; or the R3 group is attached to the carbon atom adjacent to the nitrogen atom attached to the benzothiazolyl group, the benzoimidazolyl group, or the benzooxazolyl group, when x is 0; the carbon to which the R3 group is attached is in the (S) configuration; and R3 is -(CrC4)alkyl unsubstituted or substituted with one or more halo groups. In another embodiment, the Benzoazolylpiperazine Compound has an R3 group; the R3 group is attached to a carbon atom adjacent to a nitrogen attached to the -(A)- group, when x is 1; or the R3 group is attached to the carbon atom adjacent to the nitrogen atom attached to the benzothiazolyl group, the benzoimidazolyl group, or the benzooxazolyl group, when x is 0; the carbon to which the R3 group is attached is in the (S) configuration; and R3 is -CH3. In another embodiment, the Benzoazolylpiperazine Compound has an R3 group; the R3 group is attached to a carbon atom adjacent to a nitrogen attached to the -(A)- group, when x is 1; or the R3 group is attached to the carbon atom adjacent to the nitrogen atom attached to the benzothiazolyl group, the benzoimidazolyl group, or the benzooxazolyl group, when x is 0; the carbon to which the R3 group is attached is in the (S) configuration; and R3 is -CF3. In another embodiment, the Benzoazolylpiperazine Compound has an R3 group; the R3 group is attached to a carbon atom adjacent to a nitrogen attached to the -(A)- group, when x is 1; or the R3 group is attached to the carbon atom adjacent to the nitrogen atom attached to the

benzothiazolyl group, the benzoimidazolyl group, or the benzooxazolyl group, when x is 0; the carbon to which the R3 group is attached is in the (S) configuration; and R3 is -CH2CH3. In a preferred embodiment, the R3 group is attached to a carbon atom adjacent to a nitrogen attached to the -(A)- group, when x is 1; or the R3 group is attached to the carbon atom adjacent to the nitrogen atom attached to the benzothiazolyl group, the benzoimidazolyl group, or the benzooxazolyl group, when x is 0; and the R3 group is a -CH3. In another preferred embodiment, the R3 group is attached to a carbon atom adjacent to a nitrogen attached to the -(A)- group, when x is 1; or the R3 group is attached to the carbon atom adjacent to the nitrogen atom attached to the benzothiazolyl group, the benzoimidazolyl group, or the benzooxazolyl group, when x is 0 and the R3 group is a -CF3. In another preferred embodiment, the R3 group is attached to a carbon atom adjacent to a nitrogen attached to the -(A)- group, when x is 1; or the R3 group is attached to the carbon atom adjacent to the nitrogen atom attached to the benzothiazolyl group, the benzoimidazolyl group, or the benzooxazolyl group, when x is 0; and the R3 group is a -CH2CH3. In another preferred embodiment, the R3 group is attached to a carbon atom adjacent to a nitrogen attached to the -(A)- group, when x is 1; or the R3 group is attached to the carbon atom adjacent to the nitrogen atom attached to the benzothiazolyl group, the benzoimidazolyl group, or the benzooxazolyl group, when x is 0; and the carbon to which the R3 group is attached is in the (R) configuration. In another preferred embodiment, the R3 group is attached to a carbon atom adjacent to a nitrogen attached to the -(A)- group, when x is 1; or the R3 group is attached to the carbon atom adjacent to the nitrogen atom attached to the benzothiazolyl group, the benzoimidazolyl group, or the benzooxazolyl group, when x is 0; the carbon to which the R3 group is attached is in the (R) configuration; and the R3 group is a -CH3. In another preferred embodiment, the R3 group is attached to a carbon atom adjacent to a nitrogen attached to the -(A)- group, when x is 1; or the R3 group is attached to the carbon atom adjacent to the nitrogen atom attached to the benzothiazolyl group, the benzoimidazolyl group, or the benzooxazolyl group, when x is 0; the carbon to which the R3 group is attached is in the (R) configuration; and the R3 group is a -CF3. In another preferred embodiment, the R3 group is attached to a carbon atom adjacent to a nitrogen attached to the -(A)- group, when x is 1; or the R3 group is attached to the carbon atom adjacent to the nitrogen atom attached to the benzothiazolyl group, the benzoimidazolyl group, or the

































































































"a" means the Benzoazolylpiperazine Compound is racemic.
"b" means the carbon atom of the piperazine ring attached to the methyl group
is in the R configuration.
"c" means the carbon atom of the piperazine ring attached to the methyl group
5 is in the S configuration.













































"a" means the Benzoazolylpiperazine Compound is racemic. "b" means the carbon atom of the piperazine ring attached to the methyl group is in the R configuration.
"c" means the carbon atom of the piperazine ring attached to the methyl group 5 is in the S configuration.























"a" means the Benzoazolylpiperazine Compound is facemic.
"b" means the carbon atom of the piperazine ring attached to the methyl group is in the R configuration.
"c" means the carbon atom of the piperazine ring attached to the methyl group is in the S configuration.













































"a" means the Benzoazolylpiperazine Compound is racemic.
"b" means the carbon atom of the piperazine ring attached to the methyl group is in the R configuration.
"c" means the carbon atom of the piperazine ring attached to the methyl group is in the S configuration.

Documents:

1690-chenp-2005 abstract granted.pdf

1690-chenp-2005 claims granted.pdf

1690-chenp-2005 description (complete) granted-1.pdf

1690-chenp-2005 description (complete) granted-10.pdf

1690-chenp-2005 description (complete) granted-11.pdf

1690-chenp-2005 description (complete) granted-2.pdf

1690-chenp-2005 description (complete) granted-3.pdf

1690-chenp-2005 description (complete) granted-4.pdf

1690-chenp-2005 description (complete) granted-5.pdf

1690-chenp-2005 description (complete) granted-6.pdf

1690-chenp-2005 description (complete) granted-7.pdf

1690-chenp-2005 description (complete) granted-8.pdf

1690-chenp-2005 description (complete) granted-9.pdf

1690-chenp-2005 description (complete) granted.pdf

1690-chenp-2005-abstract.pdf

1690-chenp-2005-claims.pdf

1690-chenp-2005-correspondnece-others.pdf

1690-chenp-2005-correspondnece-po.pdf

1690-chenp-2005-description(complete)balance ii.pdf

1690-chenp-2005-description(complete)balance iii.pdf

1690-chenp-2005-description(complete)i.pdf

1690-chenp-2005-form 1.pdf

1690-chenp-2005-form 3.pdf

1690-chenp-2005-form 5.pdf

1690-chenp-2005-others.pdf

1690-chenp-2005-pct.pdf


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Patent Number 228162
Indian Patent Application Number 1690/CHENP/2005
PG Journal Number 10/2009
Publication Date 06-Mar-2009
Grant Date 28-Jan-2009
Date of Filing 25-Jul-2005
Name of Patentee EURO-CELTIQUE, S.A.
Applicant Address 122, boulevard de la Petrusse, L-2330 Luxembourg,
Inventors:
# Inventor's Name Inventor's Address
1 SUN, Qun 19 Aldgate Court, Princeton, NJ 08540,
2 TAFESSE, Laykea 11 Abbington Lane, Robinsville, NJ 08691,
3 VICTORY, Sam 131 Winding Lane, Newtown, PA 18940,
PCT International Classification Number C07D 417/12
PCT International Application Number PCT/US03/41100
PCT International Filing date 2003-12-22
PCT Conventions:
# PCT Application Number Date of Convention Priority Country
1 60/473,856 2003-05-29 U.S.A.
2 60/435,917 2002-12-24 U.S.A.
3 60/459,626 2003-04-03 U.S.A.