Title of Invention

CLIP FOR CLAMPING SHEETS OF PAPER,METAL OR THE LIKE

Abstract

The invention relates to a clip for clipping together sheets which are made of paper, plastic, metal etc, on the corners or sides thereof. Said clip is U-shaped and comprises two similar or different limbs. The stack of paper is clipped together between said two limbs or by means of projections incorporated therein. The invention is characterised in that said clip is embodied as a triangular single piece or is trapezium-shaped or is shaped like a semi-circle or is semi-elliptically shaped with limbs (1, la, or lb) which are arranged parallel to each other when in the rest position. The two limbs (1, la, or 1b) comprise a small fold (3), which is inwardly curved and which bends to form an acute or obtuse angle (3a), on each side (4) forming an acute angle or an obtuse angle (4a) with the back (2) or on each vertex (8).; The two limbs (6) are arranged on top of each other, parallel to each other and are connected together without mutual contact by means of a spring (7) both in a rest position and also in a position wherein a stack of sheets is clipped. The clip is displaced in the direction of the edge (4) or the back (2) on the stack of paper and is clipped by the pre-tensed back (2) or the spring (7) and the folds (3) which are inwardly curved.

Full Text

This invention concerns a clip for clamping sheets of paper, plastic, metal or the like at heir corners or sides which is configured U shaped, one-piece or multipart. There are several kinds of clips of different designs in principle: On the one hand staples, which perforate the paper and which can only be removed with difficulty and on the other hand clips based on friction, which can in turn essentially be divided into two groups, i.e.: paper clips consisting of a piece of wire, plastic or sheet metal or spring-loaded clamping devices with attached handles. In the case of the conventional paper clip and the sheet metal clamp, the latter group of clips, which are based on a clamping effect, have the disadvantage of low holding ability, while, due to the necessary handles, the other devices are cumbersome, multipart and bulky and also of only limited functionality, since the closing and opening mechanism is not separated from the clipping mechanism. The one-piece clips of WO 2001/58700A, DE 42 39 544A, US 59 70 777A, GB 1 206 538A, DE 381 810C have two faults: 1. Those, which can be easily slipped onto a stack of sheets, only have low clamping power due to the material or because they clamp by means of surfaces. 2. The only clip with high clamping power (WO 01/58700A) is however very difficult to remove from the stack. This invention aims to provide remedial measures and to disclose a clip wherewith the sheets that are to be held together are pressed directly against each other and are fixed, without damaging the sheets, by means of spring-loaded triangular or trapezoidal or semicircular or semielliptical limbs and by inwardly bent folds. The clamping effect of this clip is almost comparable with that of a positive locking clip. According to this invention, these goals are achieved by means of the technical features characterized in claims 1 to 3. The invention is described in greater detail in the following by means of the drawings. Figs. 1 - 3 show a triangular form of a one-piece clip of this invention. Fig. 1 shows this clip in horizontal projection, Fig. 2 in lateral projection and Fig. 3 in oblique projection. Figs. 4-6 show a trapezoidal and semicircular design of the clips of Figs. 1 - 3. Figs. 7 -9 show a multipart clip of this invention, whose limbs are almost identical with that of Figs. 1 -3. The clip, as represented in Figs. 1 - 6, has two mirror-image limbs, 1, la, lb, which are connected with each other so as to swivel elastically along a back 2. Since the clip is intended to grasp the paper stack on one corner and since the stack must be easily separable, the limbs 1, la, lb are made to be triangular or trapezoidal or semicircular or semielliptical. The clip, as shown in Fig. 7-9 has two limbs 6, which are movably connected with one another or by a spring 7 such that, both in the relaxed state of the clip and in the state in which a stack of sheets is clamped, both limbs 6 are located on top of each other and parallel to each other, without mutual contact. As shown in Fig. 1A and Fig. IB, the inwardly curved folds 3 are respectively located on one side 4 of the two limbs 1, la, 6 (Fig. 1, 4, 7) arranged at an acute or obtuse angle 4a with respect to the back 2 or in the region of the vertex 8 of the two limbs lb (Fig. 5). The clip is neither opened nor closed, it is only applied to the paper stack with the curve 5 of the limbs 1, la, 6 or with the curve 5a of the limbs lb and pushed over the paper stack by finger pressure 4', 2' in the direction of the edge 4 or toward the back 2. It is removed by pushing in the direction opposite to 4' or 2An absolutely reliable stop of the clamped sheets is ensured by the fold 3 which is beveled at an angle 3a. This clip can be made of metal, high-strength plastic, wood or paper or compressed cellulose. WE CLAIM: 1. Sulfonamide compounds of general formula (la), R6 (Formula Removed) wherein R1 represents a -NR7R8 radical or a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as a ring member containing cycloaliphatic radical, which may be condensed with a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as a ring member containing mono-or bicyclic cycloaliphatic ring system, R2, R3, R4, R5 and R6, identical or different, each represent hydrogen, halogen, cyano, nitro, a saturated or unsaturated, linear or branched aliphatic radical, a linear or branched alkoxy radical, a linear or branched alkylthio radical, hydroxy, trifluoromethyl, a saturated or unsaturated cycloaliphatic radical, an alkylcarbonyl radical, a phenylcarbonyl or a - NR9R10 group, R7 and R8, identical or different, each represent hydrogen or a saturated or unsaturated, optionally at least mono-substituted linear or branched aliphatic radical, with the proviso that R8 and R9 are not hydrogen at the same time, and if one of them, R8 or R9, is a saturated or unsaturated, linear or branched, optionally at least mono-substituted C1-C4 aliphatic radical, the other one is a saturated or unsaturated, linear or branched, optionally at least mono-substituted aliphatic radical with at least five carbon atoms, or R7 and R8, together with the bridging nitrogen atom form a saturated or unsaturated, optionally at least mono-substituted, optionally at least one further heteroatom as a ring member containing heterocyclic ring which may be condensed with a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as a ring member containing mono-or bicyclic cycloaliphatic ring system, R9 and R10, identical or different, each represent hydrogen or a saturated or unsaturated, linear or branched, optionally at least mono-substituted aliphatic radical, or R9 and R10, together with the bridging nitrogen atom form a saturated or unsaturated, optionally at least mono-substituted, optionally at least one further heteroatom as a ring member containing heterocyclic ring which may be condensed with a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as a ring member containing mono-or bicyclic cycloaliphatic ring system, A and B, together with the carbon atom to which they are bonded, form a saturated or unsaturated, but not aromatic, optionally at least mono-substituted cycloalkyl ring, and n is 0, optionally in form of one of their stereoisomers, preferably enantiomers or diastereomers, their racemate or in form of a mixture of at least two of their stereoisomers, preferably enantiomers or diastereomers, in any mixing ratio, or a salt thereof, preferably a corresponding physiologically acceptable salt thereof or a corresponding solvate thereof. 2. The compounds as claimed in claim 1, wherein R1 represents a-NR7R8 radical or a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as a ring member containing 5-or 6-membered cycloaliphatic radical, which may be condensed with a saturated or unsaturated, optionally at least mono- substituted, optionally at least one heteroatom as a ring member containing mono-or bicyclic cycloaliphatic ring system, whereby the rings of the ring system are 5-or 6-membered, preferably a NR7R8 radical or a radical chosen from the group consisting of (Formula Removed) wherein, if present, the dotted line represents an optional chemical bond, and R19 represents hydrogen, a linear or branched C1-C6 alkyl radical or a benzyl radical, preferably hydrogen or a C1-C2 alkyl radical. 3. The compounds as claimed in claim 1 or 2, wherein R2, R3, R4, R5 and R6, identical or different, each represent hydrogen, F, C1, Br, cyano, nitro, a linear or branched C1-6 alkyl radical, a linear or branched C2-6 alkenyl radical, a linear or branched C2-6 alkynyl radical, a linear or branched C1-6 alkoxy, a linear or branched C1-6 alkylthio, hydroxy, trifluoromethyl, a saturated or unsaturated C3-8 cycloaliphatic radical, a linear or branched C1-6 alkylcarbonyl radical, phenylcarbonyl or an -NR9R10 group, preferably H, F, CI, NO2, NH2 or a C1-2 alkyl radical. 4. The compounds as claimed in one or more of claims 1 to 3, wherein R7 and R8, identical or different, each represent hydrogen, a linear or branched, optionally at least mono-substituted C1-10 alkyl radical, a linear or branched, optionally at least mono-substituted, C2-10 alkenyl radical, or a linear or branched, optionally at least mono-substituted, C2-10 alkynyl radical or R7 and R8, together with the bridging nitrogen form a saturated or unsaturated, optionally at least mono-substituted, optionally at least one further heteroatom as a ring member containing 5-or 6-membered heterocyclic ring which may be condensed with a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as a ring member containing mono-or bicyclicc cycloaliphatic ring system, whereby the rings of the ring system are 5-6-or 7- membered. 5. The compounds as claimed in claim 4, wherein R7 and R8, identical or different, each represent hydrogen or a linear or branched C1-10 alkyl radical or R7 and R8, together with the bridging nitrogen atom form a radical chosen from the group consisting of (Formula Removed) wherein R20, if present, is hydrogen, a linear or branched C1-C6 alkyl radical or a benzyl radical, preferably hydrogen, or a C1-C2 alkyl radical. 6. The compounds as claimed in one or more of claims 1 to 5, wherein R9 and R10, identical or different, each represent hydrogen, a linear or branched, optionally at least mono-substituted C1-C10 alkyl radical, a linear or branched, optionally at least mono-substituted C2-C10 alkenyl radical or a linear or branched, optionally at least mono- substituted C2-C10 alkynyl radical or R9 and R10, together with the bridging nitrogen atom form a saturated or unsaturated, optionally at least mono-substituted, optionally at least one further heteroatom as a ring member containing 5-or 6-membered heterocyclic ring, which may be condensed with a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as a ring member containing mono-or bicyclic cycloaliphatic ring system whereby the rings of the ring system are 5-6-or 7- membered. 7. The compounds as claimed in claim 6, wherein R9 and R10, identical or different, each represent hydrogen or a linear or branched C1-C10 alkyl radical, or R9 and R10, together with the bridging nitrogen atom form a radical chosen from a group consisting of (Formula Removed) wherein R20, if present, is hydrogen, a linear or branched C1-C6 alkyl radical or a benzyl radical, preferably hydrogen, or a C1-C2 alkyl radical. 8. The compounds as claimed in one or more of claims 1-7, wherein A and B, identical or different, each represent a linear or branched C1-C6 alkyl radical, a linear or branched C2-C6 alkenyl radical or a linear or branched C2-C6 alkynyl radical, preferably a linear or branched C1-C6 alkyl radical, or A and B, together with the carbon atom to which they are bonded, form a saturated or unsaturated, but not aromatic, optionally at least mono-substituted cycloalkyl ring, preferably a C3-C8 cycloalkyl ring, more preferably a cyclohexyl ring. 9. The compounds as claimed in one or more of claims 1 to 8, wherein the compound is selected from a group consisting of [11 l-Cyclohexanesulfonyl-3- (1-methyl-l, 2,3, 6-tetrahydropyridine-4-yl)-5-nitro-1 H-indole, [21 5-Chloro-l-cyclohexanesulfonyl-3-(l-methyl-l, 2,3, 6- tetrahydropyridine-4-yl)-l H-indole, [31 5-Amino-l-cyclohexanesulfonyl-3- (1-methyl-l, 2,3, 6- tetrahydropyridine-4-yl)-l H-indole and [41 l-Cyclohexanesulfonyl-5-fluoro-3- (1, 2,3, 5,8, 8a-hexahydro-indolizine- 7-yl)-l H-indole hydrochloride and their corresponding salts and solvates. 10. Sulfonamide compounds as claimed in claim 1 of general formula (lb), (Formula Removed) wherein R1 is a -NR7R8 radical R2, R3, R4, R5 and R6, identical or different, each represent hydrogen, halogen, cyano, nitro, a saturated or unsaturated, linear or branched aliphatic radical, a linear or branched alkoxy radical, a linear or branched alkylthio radical, hydroxy, trifluoromethyl, a saturated or unsaturated cycloaliphatic radical, an alkylcarbonyl radical, a phenylcarbonyl or a- NR9R10 group, R7 and R8, identical or different, each represent hydrogen or a saturated or unsaturated, optionally at least mono-substituted linear or branched CI-4 aliphatic radical, R9 and R10, identical or different, each represent hydrogen or a saturated or unsaturated, linear or branched, optionally at least mono-substituted aliphatic radical, or R9 and R10, together with the bridging nitrogen atom form a saturated or unsaturated, optionally at least mono-substituted, optionally at least one further heteroatom as a ring member containing heterocyclic ring which may be condensed with a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as a ring member containing mono-or bicyclic cycloaliphatic ring system, A and B, together with the carbon atom to which they are bonded, form a saturated or unsaturated, but not aromatic, optionally at least mono-substituted cycloalkyl ring, and n is 0 ; optionally in form of one of its stereoisomers, preferably enantiomers or diastereomers, their racemate or in form of a mixture of at least two of their stereoisomers, preferably enantiomers or diastereomers, in any mixing ratio, or a salt thereof, preferably a corresponding physiologically acceptable salt therof or a corresponding solvate thereof. 11. The compounds as claimed in claim 10, wherein R2, R3, R4, R5 and R6, identical or different, each represent hydrogen, F, C1, Br, cyano, nitro, a linear or branched C1-C6 alkyl radical, a linear or branched C2-C6 alkenyl radical, a linear or branched C2-C6 alkynyl radical, a linear or branched C1-C6-alkoxy, a linear or branched C1-C6alkylthio, hydroxy, trifluoromethyl, a saturated or unsaturated C3-C8 cycloaliphatic radical, a linear or branched C1-C6- alkylcarbonyl radical, phenylcarbonyl or an- NR9R10 group, preferably H, F, CI, NO2, NH2 or a C1-C2 alkyl radical. 12. The compounds as claimed in claim 10 or 11, wherein R7 and R8, identical or different, wherein R7 and R8, identical or different, each represent hydrogen, a linear or branched, optionally at least mono- substituted C1-C4 alkyl radical, preferably hydrogen or a C1-C2 alkyl radical, with the proviso that R7 and R8 are not hydrogen at the same time. 13. The compounds as claimed in one or more of claims 10 to 12, wherein R9 and R10, identical or different, each represent hydrogen, a linear or branched, optionally at least mono-substituted C1-C10 alkyl radical, a linear or branched, optionally at least mono- substituted C2-C10 alkenyl radical, or a linear or branched, optionally at least mono-substituted C2-C10 alkynyl radical or R9 and R10, together with the bridging nitrogen atom form a saturated or unsaturated, optionally at least mono-substituted, optionally at least one further heteroatom as a ring member containing 5-or 6-membered heterocyclic which may be condensed with a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as a ring member containing mono-or bicyclicc cycloaliphatic ring system, whereby the rings of the ring system are 5-6-or 7-membered. 14. The compounds as claimed in claim 13, wherein R9 and R10, identical or different, each represent hydrogen or a linear or branched C1- C10 alkyl radical, or R9 and R10, together with the bridging nitrogen atom form a radical chosen from a group consisting of (Formula Removed) wherein R20, if present, represents hydrogen, a linear or branched C1-C6 alkyl radical or a benzyl radical, preferably hydrogen, or a C1-C2 alkyl radical. 15. The compounds as claimed in claim 1, wherein A and B, together with the carbon atom to which they are bonded, form a saturated or unsaturated, but not aromatic, optionally at least mono-substituted cycloalkyl ring, preferably a C3-C8 cycloalkyl ring, more preferably a cyclohexyl ring. 16. A process for obtaining a sulfonamide derivative of general formula (la) and/or (lb), as claimed in claim 1, wherein at least one compound of general formula (II), or one of its suitably protected derivatives, (Formula Removed) wherein A and B have the meaning as claimed in one or more of claims 1 to 15 and X is an acceptable leaving group, preferably an halogen atom, more preferably chlorine, is reacted with at least one substituted indole of general formula (III) (Formula Removed) wherein R1-R6 and n have the meaning according to one or more of claims 1 to 15, or one of their suitable protected derivatives, and, if necessary, the protective groups are removed. 17. A medicament comprising at least one compound as claimed in one or more of claims 1 to 9 and optionally one or more pharmacologically acceptable excipients. 18. The compound as claimed in claims 1 to 9 wherein said compound is useful as a 5-HT6 receptor regulation agent.

Documents:

3827-DELNP-2005-Abstract-(13-01-2009).pdf

3827-DELNP-2005-Abstract-05-12-2008.pdf

3827-delnp-2005-abstract.pdf

3827-delnp-2005-assignment.pdf

3827-DELNP-2005-Claims-(13-01-2009).pdf

3827-DELNP-2005-Claims-05-12-2008.pdf

3827-delnp-2005-claims.pdf

3827-DELNP-2005-Correspondence-Others-(13-01-2009).pdf

3827-DELNP-2005-Correspondence-Others-05-12-2008.pdf

3827-DELNP-2005-Description (Complete)-(13-01-2009).pdf

3827-delnp-2005-description (complete).pdf

3827-delnp-2005-drawings.pdf

3827-DELNP-2005-Form-1-(13-01-2009).pdf

3827-DELNP-2005-Form-1-05-12-2008.pdf

3827-delnp-2005-form-1.pdf

3827-delnp-2005-form-18.pdf

3827-DELNP-2005-Form-2-(13-01-2009).pdf

3827-DELNP-2005-Form-2-05-12-2008.pdf

3827-delnp-2005-form-2.pdf

3827-DELNP-2005-Form-3-(13-01-2009).pdf

3827-delnp-2005-form-3.pdf

3827-delnp-2005-form-5.pdf

3827-delnp-2005-gpa.pdf

3827-delnp-2005-pct-210.pdf

3827-delnp-2005-pct-304.pdf