Title of Invention	HETEROCYCLYLALKYL PIPERIDINE COMPOUND AND A PROCESS FOR PREPARING THE SAME
Abstract	The present invention relates to a heterocylalkylpiprine compound of gemeral formula I in therir enantiomeric or distereolsomeric forms or mixtures of these forms and/or, where appropriate, in their syn or anti form or a mixture thereof, as well as any salt thereof.

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HETEROCYCLYLALKYLPIPERIDINE DERIVATIVES, THEIR PREPARATION AND COMPOSITIONS CONTAINING SAME The present invention relates to heterocyclyl-alkylpiperidine derivatives of general formula: which are active as antimicrobial agents. The invention also relates to their preparation and to compositions containing them. Patent applications WO 99/37635 and WO 00/43383 disclose antimicrobial quinolylpropylpiperidine derivatives of general formula: in which the radical R1 is especially (Cl-6) alkoxy, R2 is hydrogen, R3 is in position -2 or -3 and represents (Cl-6) alkyl which may optionally be substituted with 1 to 3 substituents chosen from thiol, halogen, alkylthio, trifluoromethyl, carboxyl, alkyloxycarbonyl, alkylcarbonyl, alkenyloxycarbonyl, alkenylcarbonyl, hydroxyl optionally substituted with alkyl, etc., R4 is a group -CH2-R5 for which R5 is selected from alkyl, hydroxyalkyl, alkenyl, alkynyl, tetrahydrofuryl, optionally substituted phenylalkyl, optionally substituted phenylalkenyl, optionally substituted heteroarylalkyl, optionally substituted heteroaryl, etc., n is 0 to 2, m is 1 or 2 and A and B are especially oxygen, sulfur, sulfinyl, sulfonyl, NRn, CReR7 for which R6 and R7 represent H, thiol, alkylthio, halo, trifluoromethyl, alkenyl, alkenylcarbonyl, hydroxyl, amino, and Z1 to Z5 are N or CR1a, etc. These products show antimicrobial activity. However, no derivative disubstituted in position -4 of the piperidine had been synthesized hitherto and consequently no biological activity had been discovered for such products either. Since slight modifications to the structures already known can result in large variations in activity, it was not obvious that derivatives disubstituted in position -4 of the piperidine would also have antibacterial activity. European patent application EP 30044 discloses quinoline derivatives which are useful as cardiovascular agents, corresponding to the general formula: in which R1 is especially alkyloxy, A-B is -CH2-CH2-, -CHOH-CH2-, -CH2-CHOH-, -CH2-CO- or -CO-CH2-, Ri is H, OH or alkyloxy, R2 is ethyl or vinyl, R3 is especially alkyl, hydroxyalkyl, cycloalkyl, hydroxyl, alkenyl, alkynyl, tetrahydrofuryl, phenylalkyl, optionally substituted diphenylalkyl, optionally substituted phenylalkenyl, optionally substituted benzoyl or benzoylalkyl, optionally substituted heteroaryl or heteroarylalkyl, and Z is H or alkyl or forms with R3 a cycloalkyl radical. It has now been found, and this forms the subject of the present invention, that the products of general formula (I) for which: Xi, X2, X3, X4 and X5 represent, respectively, >C-R'1 to >C-R'5, or alternatively not more than one of them represents a nitrogen atom, R1, R'l, R'2, R'3, R'4 and R'5 are identical or different and represent a hydrogen or halogen atom or an alkyl, cycloalkyl, phenyl, phenylthio, mono- or bicyclic aromatic heterocyclyl or heterocyclylthio, hydroxyl, alkyloxy, trifluoromethoxy, alkylthio, trifluoromethylthio, cycloalkyloxy, cycloalkylthio, cyano, carboxyl, alkyloxycarbonyl, cycloalkyloxycarbonyl, -NRaRb or -CONRaRb radical (for which Ra and Rb can represent hydrogen, alkyl, cycloalkyl, phenyl, mono- or bicyclic aromatic heterocyclyl or Ra and Rb form, together with the nitrogen atom to which they are attached, a 5- or 6-membered heterocycle which can optionally contain another heteroatom chosen from 0, S and N and, where appropriate, bearing an alkyl, phenyl or mono- or bicyclic aromatic heterocyclyl substituent on the nitrogen atom or, where appropriate, the sulfur atom of which is oxidized in the form of sulfinyl or sulfonyl), or represent a methylene radical substituted with fluoro, hydroxyl, alkyloxy, alkylthio, cycloalkyloxy, cycloalkylthio, phenyl, mono- or bicyclic aromatic heterocyclyl, carboxyl, alkyloxycarbonyl, cycloalkyloxycarbonyl, -NRaRb or -CONRaRb for which Ra and Rb are defined as above, or represent phenoxy, heterocyclyloxy, benzyloxy, heterocyclylmethyloxy, or alternatively Ri can also represent difluoromethoxy, or a radical of structure -CniF2in+i/ -SCmF2m+i or -0CmF2m+i for which m is an integer from 1 to 6, or alternatively R's can also represent trifluoroacetyl, R2 represents carboxyl, alkyloxycarbonyl, cycloalkyloxycarbonyl, cyano, -CONRaRb (for which Ra and Rb represent, respectively, hydrogen, alkyl, cycloalkyl, phenyl, mono- or bicyclic aromatic heterocyclyl, or Ra or Rb represents hydroxyl, alkyloxy, cycloalkyloxy, or Ra and Rb form, together with the nitrogen atom to which they are attached, a 5- or 6-membered heterocycle which can optionally contain another heteroatom chosen from 0, S and N and, where appropriate, bearing an alkyl, phenyl or mono- or bicyclic aromatic heterocyclyl substituent on the nitrogen atom or, where appropriate, the sulfur atom of which is oxidized in the form of sulfinyl or sulfonyl), or R2 represents hydroxymethyl, alkyl containing 1 or 2 carbon atoms substituted with carboxyl, alkyloxycarbonyl, cycloalkyloxycarbonyl, cyano or -CONRaRb for which Ra and Rb are defined as above, or R2 represents a radical of structure -CF2-RC, -C(CH3)2-Rc, -CO-Rc, -CHOH-Rc, -C(cycloalkyl)-Rc, or -CH=CH-Rc for which Rc is carboxyl, alkyloxycarbonyl, cycloalkyloxycarbonyl, or -CONRaRb for which Ra and Rb are defined as above, R3 represents a phenyl, mono- or bicyclic aromatic heterocyclyl or alk-R°3 radical for which alk is an alkyl radical and R°3 represents hydrogen, halogen, hydroxyl, alkyloxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, dialkylamino, cycloalkyl, cycloalkyloxy, cycloalkylthio, cycloalkylsulfinyl, cycloalkylsulfonyl, cycloalkylamino, N-cycloalkyl-N-alkylamino, -N-(cycloalkyl)2/ acyl, cycloalkylcarbonyl, phenyl, phenoxy, phenylthio, phenylsulfinyl, phenylsulfonyl, phenylamino, N-alkyl-N-phenylamino, N-cycloalkyl-N-phenylamino, -N-(phenyl)2, phenylalkyloxy, phenylalkylthio, phenylalkylsulfinyl. phenylalkylsulfonyl, phenylalkylamino, N-alkyl-N-phenylaminoalkyl, N-cycloalkyl-N-phenylalkylamino, benzoyl, mono- or bicyclic aromatic heterocyclyl, heterocyclyloxy, heterocyclylthio, heterocyclylsulfinyl, heterocyclylsulfonyl, heterocyclylamino, N-alkyl-N-heterocyclylamino, N- cycloalkyl-N-heterocyclylamino, heterocyclylcarbonyl, heterocyclylalkyloxy, heterocyclylalkylthio, heterocyclylalkylsulfinyl, heterocyclylalkylsulfonyl, heterocyclylalkylamino, N-alkyl-N-heterocyclylaminoalkyl, N-cycloalkyl-N-heterocyclylaminoalkyl, (the heterocyclyl portions mentioned above being mono- or bicyclic aromatic), carboxyl, alkyloxycarbonyl, -NRaRb or -CO-NRaRb for which Ra and Rb are defined as above in the definition of R2, or alternatively R°3 represents -CR'b=CR'c-R'a for which R'a represents phenyl, phenylalkyl, heterocyclyl or heterocyclylalkyl in which the heterocyclyl portion is mono- or bicyclic aromatic, phenoxyalkyl, phenylthioalkyl, phenylsulfinylalkyl, phenylsulfonylalkyl, phenylaminoalkyl, N-alkyl-N-phenylaminoalkyl, heterocyclyloxyalkyl, heterocyclylthioalkyl, heterocyclylsulfinylalkyl, heterocyclylsulfonylalkyl, heterocyclylaminoalkyl, N-alkyl-N-heterocyclylaminoalkyl, heterocyclylthio, heterocyclylsulfinyl, heterocyclylsulfonyl, (the heterocyclyl portions mentioned above being mono- or bicyclic aromatic), phenylthio, phenylsulfinyl, phenylsulfonyl; and for which R'b and R'c represent hydrogen, alkyl or cycloalkyl, or alternatively R°3 represents a radical -C=C-Rd for which Rd is alkyl, phenyl, phenylalkyl, phenoxyalkyl, phenylthioalkyl, N-alkyl-N-phenylaminoalkyl, mono- or bicyclic aromatic heterocyclyl, heterocyclylalkyl, heterocyclyloxyalkyl, heterocyclylthioalkyl, heterocyclylaminoalkyl, N-alkyl-N-heterocyclylaminoalkyl, (the heterocyclyl portions mentioned above being mono- or bicyclic aromatic), or alternatively R°3 represents a -CFa-phenyl or mono- or bicyclic aromatic -CF2-heterocyclyl radical, Y represents a radical >CH-Re for which Re is hydrogen, fluoro, hydroxyl, alkyloxy, cycloalkyloxy, carboxyl, alkyloxycarbonyl, cycloalkyloxycarbonyl, -NRaRb or -CO-NRaRb for which Ra and Rb are defined as above for R2 or one represents a hydrogen atom and the other represents an alkyloxycarbonyl, acyl, cycloalkylcarbonyl, benzoyl or heterocyclylcarbonyl radical in which the heterocyclyl portion is mono- or bicyclic aromatic, or alternatively Y represents a difluoromethylene, carbonyl, hydroxyiminomethylene, alkyloxyiminomethylene or cycloalkyloxyiminomethylene radical or a 1,1-cyclo-alkylene radical containing 3 to 6 carbon atoms, and n is an integer from 0 to 4 it being understood that the phenyl, benzyl, benzoyl or heterocyclyl radicals or portions mentioned above may optionally be substituted on the ring with 1 to 4 substituents chosen from halogen, hydroxyl, alkyl, alkyloxy, alkyloxyalkyl, haloalkyl, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, carboxyl, alkyloxycarbonyl, cyano, alkylamino, -NRaRb for which Ra and Rb are defined as above, phenyl, hydroxyalkyl, alkylthioalkyl, alkylsulfinylalkyl and alkylsulfonylalkyl, in their enantiomeric or diastereoisomeric forms or mixtures of these forms, and/or, where appropriate, in their syn or anti form or a mixture thereof, as well as the salts thereof, are powerful antibacterial agents. It is understood that the alkyl or acyl radicals and portions contain (except where especially mentioned) 1 to 10 carbon atoms in a straight or branched chain and that the cycloalkyl radicals contain 3 to 6 carbon atoms. It is also understood that the radicals which represent or bear a halogen atom represent a halogen chosen from fluorine, chlorine, bromine and iodine, preferably fluorine. In the above general formula, when the radicals represent or bear a mono- or bicyclic aromatic heterocyclyl substituent, this substituent contains 5 to 10 chain members and may be chosen {in a nonlimiting manner) from thienyl, furyl, pyrrolyl, imidazolyl, thiazolyl, oxazolyl, thiadiazolyl, oxadiazolyl, tetrazolyl, pyridyl, pyridazinyl, pyrazinyl, pyrimidinyl, indolyl, benzothienyl, benzofuryl indazolyl, benzothiazolyl, naphthyridinyl, quinolyl, isoquinolyl, cinnolyl, quinazolyl, quinoxalyl, benzoxazolyl and benzimidazolyl which may optionally be substituted with the substituents listed above. According to the invention, the products of general formula (I) may be obtained by coupling the chain R3 with the heterocyclylalkylpiperidine derivative of general formula: in which X1, X2, X3, X4, X5, R1, R2, Y and n are defined as above, and R2 is protected when it bears a carboxyl or amino radical, optionally followed by removal of the acid-protecting or amine-protecting radical, optional separation of the enantiomeric or diastereoisomeric forms and/or, where appropriate, of the syn or anti forms and optional conversion of the product obtained into a salt. The coupling of the chain R3 with the piperidine is advantageously carried out by the action of a derivative of general formula: R3-X (IIa) in which R3 is defined as above and X represents a halogen atom, a methylsulfonyl radical, a trifluoromethylsulfonyl radical or a p-toluenesulfonyl radical, working in anhydrous medium, which is preferably inert (for example nitrogen or argon) in an organic solvent such as an amide (for example dimethylformamide), a ketone (for example acetone) or a nitrile (for example acetonitrile) in the presence of a base such as an organonitrogen base (for example triethylamine) or a mineral base (alkaline carbonate, for example potassium carbonate) at a temperature of between 2 0°C and the reflux temperature of the solvent. It is understood that the nitrogen atom of the piperidine in the derivative of general formula (II) is optionally protected according to the usual methods which do not affect the rest of the molecule or the reaction; for example, the protection is carried out by a protecting radical chosen from t-butoxycarbonyl and benzyloxycarbonyl. Preferably, a derivative of general formula (Ila) for which X is a bromine or iodine atom is reacted. When R3 is a phenyl radical, it is also possible to act on the iodo or bromo derivative R3-X in the presence of a palladium catalyst according to the method described in J. Org. Chem., 6066 (1997) or Tet. Lett., 6359 (1997). The palladium catalyst may be chosen from tris(dibenzylideneacetone)dipalladium, and palladium diacetate with a ligand such as 2,2'-bis(diphenyl- phosphino)-1,1'-binaphthyl or 2-(di-t-butylphosphino)-biphenyl, for example, a base such as sodium tert-butoxide or cesixim carbonate in a solvent such as tetrahydrofuran, tetraglyme or toluene, optionally in the presence of a crown ether such as 18-C-6 (1,4,7,10,13,16-hexaoxacyclooctadecane). The reaction is carried out at a temperature of between 20°C and llO°C. When R3 represents a radical -alk-R°3 for which alk is an alkyl radical and R°3 represents -C=C-Rd in which Rd is phenyl, phenylalkyl, heterocyclyl or mono- or bicyclic aromatic heterocyclylalkyl, it is often preferable to couple an alkynyl halide: HC=C-alk-X for which alk is defined as above and X is a halogen atom, and then to substitute the chain with a phenyl, phenylalkyl, heterocyclyl or heterocyclylalkyl radical. In this alternative, the addition of the alkynyl chain is carried out using an alkynyl halide HC=C-alk-X for which X is preferably a bromine atom, under the conditions listed above for the coupling of the chain R3, in the presence or absence of an alkali metal iodide such as, for example, potassium iodide or sodium iodide. The substitution with a phenyl or heterocyclyl radical is carried out by the action of a halide derived from the cyclic radical to be substituted, in the presence of triethylamine, in anhydrous medium in a solvent such as an amide (for example dimethylformamide) or a nitrile (for example acetonitrile) and in the presence of a palladium salt such as, for example, tetrakis(triphenylphosphine)palladium and cuprous iodide, at a temperature of between 20°C and the reflux temperature of the solvent. The substitution with a phenylalkyl or heterocyclylalkyl radical is carried out by the action of the corresponding halide, in basic medium, for example in the presence of potassium hydride or sodium hydride or n-butyllithium, in a solvent such as an ether (tetrahydrofuran) or an amide (dimethylformamide) at a temperature of between -60°C and the boiling point of the reaction medium. It is understood that, if the alkyl radicals represented by R3 bear carboxyl or amino substituents, these substituents are protected beforehand then freed after the reaction. The process is performed according to the usual methods which do not affect the rest of the molecule, in particular according to the methods described by T.W. Greene and P.G.M. Wuts, Protective Groups in Organic Synthesis (2nd edition), A. Wiley -Interscience Publication (1991), or by McOmie, Protective Groups in Organic Chemistry, Plenum Press (1973). The protected carboxyl radical borne by R2 may be chosen from readily hydrolyzable esters. Examples which may be mentioned are the methyl, benzyl and tert-butyl esters, or the phenyl propyl or allyl esters. The protection of the carboxyl radical is optionally carried out at the same time as the reaction. Where appropriate, the amino radical is protected using the usual protecting radicals mentioned in the above references. These protecting radicals are installed and removed according to the usual methods, mentioned above for R3. When R3 represents a radical-alk-R°3 for which alk is an alkyl radical and R°3 represents a phenoxy, phenylthio, phenylamino, heterocyclyloxy, heterocyclylthio or heterocyclylamino radical in which the heterocyclyl portion is aromatic, it may be preferable to construct the chain step by step by first condensing a chain HO-alk-X, for which X is a halogen atom and preferably iodine, under the conditions described above for the reaction of the product of general formula (Ila) , and then by converting the hydroxyalkyl chain into a haloalkyl, methanesulfonylalkyl or p-toluenesulfonylalkyl chain, and finally by reacting, in basic medium, an aromatic derivative of structure Ar-ZH for which AR is an aromatic phenyl or heterocyclyl radical and Z is a sulfur, oxygen or nitrogen atom. The conversion of the hydroxylated chain into a haloalkyl or p-toluenesulfonyl chain is carried out according to the usual methods of halogenation or sulfonylation, especially by reacting a halogenating agent, for instance, thionyl chloride, halophosphorus derivatives: for example phosphorus trichloride or tri-bromide or a sulfonylating agent such as, for example, methanesulfonyl chloride, p-toluenesulfonyl chloride or trifluoromethanesulfonic anhydride. The reaction is carried out in an organic solvent, for instance a chlorinated solvent (for example dichloromethane or chloroform), at a temperature of between O°C and 60°C. In certain cases, it may be advantageous to work in the presence of a base, for instance pyridine or triethylamine. The reaction of the aromatic derivative Ar-ZH is advantageously carried out as described above for the action of the derivative of general formula (Ila), in the presence of a base, .for example such as a nitrogenous base, in an organic solvent such as an amide (for example dimethylformamide), a ketone (for example acetone) or a nitrile (for example acetonitrile), in the presence of a base such as a nitrogenous organic base (for example triethylamine) or a mineral base (alkali metal carbonate: for example potassium carbonate) at a temperature of between 20°C and the reflux temperature of the reaction mixture. It may be advantageous to work in the presence of potassium iodide. According to the invention, the heterocyclylalkylpiperidine derivatives of general formula (II) may be prepared according to the coupling method described below, and then where appropriate converted according to one of the methods ® to (D below, via a subsequent operation starting with one of the derivatives of general formula (II) already obtained, to prepare the derivatives corresponding to the various alternatives of Y and/or of R1, R'l, R'2, R'3, R'4 or R'5. It is understood that when carboxylic acid radicals are present on the molecule, these radicals are protected beforehand and then freed after the reaction according to the usual methods which do not affect the rest of the molecule, especially according to the methods mentioned in the references cited above. It is also understood that, prior to the reactions which may interfere with the amine of the piperidine in the derivative of general formula (11), this amine is protected, and then freed after the reaction. The protection is carried out according to the usual methods, as specified above, especially via a t-butoxycarbonyl or benzyloxycarbonyl radical. According to the invention, the preparation of the products of general formula (II) for which Re in Y is a hydrogen atom is carried out by coupling a heterocyclic derivative of general formula: in which Rz is a protecting radical and R"2 is defined as above or represents a protected radical if R2 represents or bears a carboxylic acid function, followed by removal of the protecting radicals and/or followed by conversion, via a subsequent operation, of the substituents of the bicycle of the heterocyclylalkylpiperidine derivative of general formula (II) thus obtained, to give the expected derivative bearing the radical R1, R'l, R'2, R'3, R'4or R'5, and, where appropriate, removal of the protecting radical(s) still present on the molecule. The radical Rz may be any protecting group for the nitrogen atom which is compatible with the reaction (for example t-butyloxycarbonyl or benzyloxycarbonyl). The protecting groups for the acid functions are chosen from the usual groups whose installation and removal do not affect the rest of the molecule, especially those mentioned in the references cited above. The reaction is carried out by the successive action of an organoborane (for example 9-borabicyclo-[3.3.l]nonane) in a solvent such as an ether (for example tetrahydrofuran or dioxane) at a temperature of between -20°C and 20°C, and then of the bicyclic derivative of general formula (III) for which Hal preferably represents a bromine or iodine atom or a chlorine atom, by analogy with the methods described by Suzuki et al, Pure and Appl. Chem. , 57, 1749 (1985). The reaction is generally carried out in the presence of a palladium salt (for example diphenylphosphinoferrocenepalladium chloride) and of a base such as potassium phosphate, at a temperature of between 20°C and the reflux temperature of the solvent. ® The heterocyclylalkylpiperidines of general formula (II) for which Re in Y represents a hydroxyl radical may be prepared by oxidation in basic medium of the corresponding heterocyclylalkylpiperidine derivative of general formula (II) for which Re in Y is a hydrogen atom. The oxidation is carried out by the action of oxygen, preferably in an inert solvent such as dimethyl sulfoxide in the presence of tert-butanol and of a base such as potassium tert-butoxide or sodium tert-butoxide at a temperature of between O°C and lOO°C. The heterocyclylalkylpiperidine derivative for which Re in Y is a fluorine atom is prepared by fluorination starting with a derivative for which Re is hydroxyl. The reaction is carried out in the presence of a sulfur fluoride [for example in the presence of an aminosulfur trifluoride (diethylaminosulfur trifluoride (Tetrahedron, £4, 2875 (1988), bis(2-methoxyethyl)aminosulfur trifluoride (Deoxofluor®) , or morpholinosulfur trifluoride, for example) or alternatively in the presence of sulfur tetrafluoride (J, Org. Chem. , 40, 3808 (1975)]; alternatively, the fluorination reaction can also be carried out using a fluorinating agent such as hexafluoropropyldiethylamine (JP 2 039 546) or N-(2-chloro-1,1,2-trifluoroethyl)diethylamine. The process is performed in an organic solvent such as a chlorinated solvent (for example dichloromethane, dichloroethane or chloroform) or in an ether (for example tetrahydrofuran or dioxane) at a temperature of between -78°C and 40°C (preferably between 0°C and 30°C)- It is advantageous to work in inert medium (especially argon or nitrogen). The heterocyclylalkylpiperidine derivative of general formula (II) for which Re in Y is an alkyloxy or cycloalkyloxy radical is prepared by the action of an alkyl or cycloalkyl halide on the corresponding derivative of general formula (II) for which Re is hydroxyl. The reaction is generally carried out using the bromide or chloride, in an inert solvent such as N,N-dimethylformamide or dimethyl sulfoxide, in the presence of an acid acceptor such as a trialkylamine (for example triethylamine) or an alkali metal hydride (for example sodium hydride), at a temperature of between 2 0°C and l00°c. The heterocyclylalkylpiperidine derivative of general formula (II) for which Y is a carbonyl radical may be prepared by oxidation of the corresponding derivative of general formula (II) for which Re in Y is a hydroxyl radical. This oxidation is carried out, for example, using potassium permanganate optionally in a solution of sodium hydroxide (for example 3N sodium hydroxide), at a temperature of between -20°C and 20°C, or alternatively by the action of oxalyl chloride in the presence of dimethyl sulfoxide, followed by the addition of an amine such as triethylamine, in an inert solvent such as dichloromethane or dimethyl sulfoxide, at a temperature of between -60°C and 20°C, by analogy with the method described by D. Swern et al., J. Org. Chem., 44, 4148 (1979). The heterocyclylalkylpiperidine derivative of general formula (II) for which Y is a difluoromethylene radical may be prepared by dihalogenation of the product of general formula (II) for which Y is carbonyl, under conditions analogous to those of the fluorination described above. The heterocyclylalkylpiperidine derivative of general formula (II) for which Y is a hydroxyimino-methylene radical may be prepared by the action of hydroxylamine on a derivative of general formula (11) for which Y is a carbonyl radical. The reaction is generally carried out in an inert solvent such as an alcohol (methanol or ethanol) and optionally in the presence of sodium hydroxide (for example IN sodium hydroxide), at a temperature of between 0°C and the boiling point of the reaction mixture, The heterocyclylalkylpiperidine derivative of general formula (II) for which Y is an alkyloxyimino-methylene or cycloalkyloxyiminomethylene radical may be prepared by the action of an alkyl or cycloalkyl halide on the corresponding derivative of general formula (II) for which Y is hydroxyiminomethylene. The reaction is generally carried out in an inert solvent such as N,N-dimethylformamide or dimethyl sulfoxide, in the presence of an acid acceptor such as a trialkylamine (for example triethylamine) or an alkali metal hydride (for example sodium hydride), at a temperature of between 2 0°C and 100°C, A bromide is preferably used. The heterocyclylalkylpiperidine derivative of general formula (II) for which Re in Y is a radical -NRaRb may be prepared from the corresponding tosyloxy derivative by the action of an amine HNRaRb (or, where appropriate, of ammonia when Re is -NH2) in an inert solvent such as N,N-dimethylformamide or dimethyl sulfoxide, at a temperature of between 20°C and the boiling point of the reaction mixture. When ammonia is reacted, the process is preferably performed under pressure (2 to 20 atmospheres) at a temperature of between 20°C and 100°C. When the process is performed using an amine HNRaRb, the reaction is optionally carried out in the presence of a base such as a trialkylamine (for example triethylamine), pyridine or an alkali metal hydride (for example sodium hydride). The derivative for which Re in Y is tosyloxy is obtained from the product of general formula (II) for which Re in Y is hydroxyl, by the action of tosyl chloride in pyridine, at a temperature of between -10°C and 20°C. The heterocyclylalkylpiperidine derivative of general formula (II) for which Re in Y is a carboxyl radical may be prepared by the action of an alkaline cyanide on the corresponding tosyloxy derivative, in an organic solvent such as dimethylformamide or dimethyl sulfoxide or in aqueous-organic medium, for example a water-alcohol mixture, at a temperature of between 0°C and the boiling point of the reaction mixture, followed by hydrolysis of the nitrile obtained by the action of a strong acid such as hydrochloric acid, and optionally of a lower aliphatic alcohol, at a temperature of between O°C and the boiling point of the reaction mixture. Sodium cyanide or potassium cyanide is preferably used. The heterocyclylalkylpiperidine derivative of general formula (II) for which Re in Y is an alkyloxycarbonyl or cycloalkyloxycarbonyl or -CO-NRaRb radical may be prepared by the action, respectively, of the alcohol or of the corresponding amine on the derivative of general formula (II) for which Re in Y is a carboxyl radical. The reaction is carried out in the presence of a coupling agent such as a carbodiimide (for example N,N'-dicyclohexylcarbodiimide) or N,N'-carbonyldiimidazole, in an inert solvent such as an ether (for example tetrahydrofuran or dioxane), an amide (N,N-dimethylformamide), a chlorinated solvent (for example methylene chloride, 1,2-dichloroethane or chloroform) or dimethyl sulfoxide, at a temperature of between 0°C and the reflux temperature of the reaction mixture. ® The heterocyclylalkylpiperidine derivative of general formula (II) for which Y is a 1,1-cycloalkylene radical may be prepared by the action, in basic medium, of a product of structure Hal-Alk-Hal for which Alk is an alkylene radical corresponding to the expected cycloalkylene, on a heterocyclylalkylpiperidine derivative for which Re in Y is a hydrogen atom. The reaction is generally carried out in an inert solvent such as N,N-dimethylformamide or dimethyl sulfoxide, in the presence of an acid acceptor such as an alkali metal hydride (for example sodium hydride), at a temperature of between 20°C and 100°C. (D The heterocyclylalkylpiperidine derivatives of general formula (II) for which one from among R1, R'l, R'2; R'3, R'4 and R'5 represents an alkyl, cycloalkyl. phenyl, heterocyclyl, benzyl or heterocyclylmethyl radical may be prepared by the action of a boron derivative of structure R'iB(0H)2 (R'i meaning one of the substituents R1, R'l, R'2, R'3/ R'4 or R'5) or of 9-alkyl- (or 9-cycloalkyl)-9-borabicyclo[3.3.l]nonane structure on a derivative of general formula (II) for which the substituent R'1 is a bromine, iodine or chlorine atom, by analogy with the methods described by F. Diederich and P. J. Stang, Metal Catalysed Cross-coupling Reactions, Wiley-VCH, (1997) in the presence of a palladium salt (for example tetrakis(triphenyl-phosphine) [lacuna] or diphenylphosphinoferrocene-palladium chloride) and of a base such as potassium phosphate, in an inert solvent such as an amide (for example N,N-dimethy1formamide), an ether (for example tetrahydrofuran) or a nitrile (for example acetonitrile), at a temperature of between 20°C and the reflux temperature of the reaction mixture. ® The heterocyclylalkylpiperidine derivatives of general formula (II) for which one from among R1, R'1, R'2, R'3, R'4 and R'5 represents a radical -NRaRb may be prepared by the action of an amine HNRaRb on a derivative of general formula (II) for which the substituent R'1 (R'i meaning one of the substituents R1, R'1, R'2, R'3, R'4 or R'5) is a bromine, iodine or chlorine atom, by analogy with the methods described in J. Org. Chem., 6066 (1997) and Tetrahedron Lett., 6359 (1997) in the presence of a palladium catalyst, under conditions similar to those described for the reaction of the halo derivative of formula (III) with the derivative of general formula (II) . When Ra and Rb represent hydrogen atoms, the amino derivative obtained may be converted into a fluoro derivative by the action of an alkaline nitrite (for example sodium nitrite) in acidic medium (tetrafluoroboric acid or hexafluorophosphoric acid) in water at a temperature of between -10°C and 20°C, to prepare a diazonium tetrafluoroborate or hexafluorophosphate, followed by pyrolysis of the product obtained according to the Baz-Schieman reaction. Org. Synth., Coll 5, 133 (1973). (D The heterocyclylalkylpiperidine derivatives of general formula (II) for which R1, R'l, R'2, R'3, R'4 or R'5 represents an alkyloxy, alkylthio, cycloalkyloxy, cycloalkylthio, benzyloxy or heterocyclylmethyloxy radical, may be prepared by the action of the alcohol or of the corresponding thiol on the heterocyclylalkylpiperidine derivative for which one of the radicals R'l is a bromine, iodine or chlorine atom. The reaction is generally carried out in an inert solvent such as an ether (for example tetrahydrofuran or dioxane), an amide (for example N,N-dimethylformamide) or dimethyl sulfoxide, in the presence of an acid acceptor such as a trialkylamine (for example triethylamine), an alkali metal hydride (for example sodium hydride), methyllithium or n-butyllithium, at a temperature of between O°C and the reflux temperature of the reaction mixture. The heterocyclylalkylpiperidine derivatives of general formula (II) for which R1, R'1, R'2, R'3, R'4 or R's represents a hydroxyl radical may be prepared from the corresponding derivative for which one of the radicals R'i is methoxy by the action of a strong acid such as hydrobromic acid, at a temperature of between 20°C and the reflux temperature of the reaction mixture. The heterocyclylalkylpiperidine derivatives of general formula (II) for which R1, R'l, R'2, R'3, R'4 or R's represents a trifluoromethoxy radical may be obtained by analogy with the method described by Sun W.Y. Synlett., 11, 1279 (1997) to prepare a derivative for which R'1 is an -O-CS-SCH3 radical, starting with the corresponding hydroxyl derivative; this radical is converted into a trifluoromethyl radical by applying the methods described by Kuroboshi M. et al., Tetrahedron Lett., 33(29), 4173 (1992) in the presence of 1,3-dibromo-5,5-dimethylhydantoin in an HF-pyridine complex at a temperature of between 0°C and 20°C. The heterocyclylalkylpiperidine derivatives of general formula (II) for which R1, R'1, R'2, R'3, R'4 or R' 5 represents an alkyloxy, cycloalkyloxy, phenoxy, benzyloxy, heterocyclyloxy or heterocyclylmethyloxy radical may be obtained by the action of the corresponding halo derivative on the derivative of general formula (II) for which the R'i to be modified is hydroxyl. The process is preferably performed using the bromo derivative, in an inert solvent such as an ether (for example tetrahydrofuran or dioxane), an amide (for example N,N-dimethylformamide) or dimethyl sulfoxide, in the presence of an acid acceptor such as a trialkylamine (for example triethylamine), an alkali metal hydride (for example sodium hydride) , methyllithium or N-butyllithium, optionally in the presence of a palladium salt [by analogy with the methods described in J. Am. Chem. Soc., 4369 (1999); Tetrahedron Lett., 8005 (1997); Angew. Chem. Int. Ed. Engl., 2047 (1998)], at a temperature of between 0°C and the reflux temperature of the reaction mixture. (D The heterocyclylalkylpiperidine derivatives of general formula (II) for which R1 represents a trifluoromethyl radical may be prepared by the action of a trifluoromethylating agent (especially a bromo derivative Br-CF3 or an iodo derivative I-CF3) on the heterocyclylalkylpiperidine derivative for which one of the radicals Ri is a bromine, iodine or chlorine atom, in the presence of copper or a copper(I) salt such as Cul, in a solvent such as dimethylformamide, between 20°C and 150°C, by analogy with J.C.S, Chem. Commun., 1, 53 (1992) or Chem. Commun., 18, 1389 (1993). ® The heterocyclylalkylpiperidine derivatives of general formula (II) for which R1, R'l, R'2, R'3, R'4 or R' 5 represents an alkylthio, cycloalkylthio, trifluoromethylthio, phenylthio or heterocyclylthio radical may be obtained by the action of the corresponding halo derivative on the heterocyclylalkylpiperidine derivative bearing a mercapto substituent. The process is preferably performed using the bromo derivative, under the conditions described above for the action of a halo derivative on an alcohol, at a temperature of between 2 0°C and the reflux temperature of the reaction mixture. In the case of the trifluoromethylthio radical, the process is performed by analogy with the method described in Tet. Lett., 33 (44), 6677 (1992) . The mercapto derivative of the heterocyclylalkylpiperidine of general formula (II) may be obtained from the heterocyclylalkylpiperidine derivative for which one of the radicals R'i is a bromine, iodine or chlorine atom (preferably a bromine atom) by analogy with the methods described by Q.L. Zhou et al.. Tetrahedron, 15, 4467 (1994); C. Bieniauz et al., Tetrahedron Letters, 34 6, 939 (1993) and E.D. Amstuts, J. Am. Chem. Soc,, 68, 498 (1946). The reaction is carried out, for example, in the presence of Na3PO3S or Na2S in an inert solvent such as an alcohol (for example methanol or ethanol), optionally in the presence of water, at a temperature of between 2 0°C and the reflux temperature of the reaction mixture. ® The heterocyclylalkylpiperidine derivatives of general formula (11) for which R1, R'l, R'2, R'3, R'4 or R'5 represents a cyano radical may be obtained from the corresponding derivative for which one of the radicals R'i is a halogen atom, preferably a bromine or iodine atom, by applying the methods described by Halley F. et al., Synth. Comm. , 27, 7, 1199 (1997) and Tschaen D. M. et al., J. Org. Chem., 60, 14, 4324 (1995), in the presence of CuCN, or KCN and optionally in the presence of a catalyst. The heterocyclylalkylpiperidine derivatives of general formula (II) for which R1, R'l, R'2, R'3, R'4 or R'5 represents a carboxyl, alkyloxycarbonyl, cycloalkyloxycarbonyl or -CO-NRaRb radical may be prepared from the cyano derivative, according to the usual methods for conversion into an acid, an ester and an amide, which do not affect the rest of the molecule, and some of the implementation conditions of which have been recalled above. In particular, in the presence of a carbodiimide (N,N'-dicyclohexylcarbodiimide) or N,N'-carbonyldiimidazole, in an ether (tetrahydrofuran or dioxane), an amide (N,N-dimethylformamide) or a chlorinated solvent (methylene chloride, 1,2-dichloroethane or chloroform), at a temperature of between 0°C and the reflux temperature of the reaction mixture. ® The heterocyclylalkylpiperidine derivatives of general formula (II) for which R1, R'l, R'2, R'3, R'4 or R'5 represents a hydroxymethyl radical may be obtained by reducing a heterocyclylalkylpiperidine derivative of general formula (II) for which one of the radicals R'1 represents a carboxyl radical, using a-reducing agent such as, for example, lithium aluminum hydride or a borohydride, in an inert solvent such as an ether (for example tetrahydrofuran or dioxane) or a chlorinated solvent (for example methylene chloride, 1,2-dichloroethane or chloroform), at a temperature of between 0°C and the reflux temperature of the reaction mixture. The heterocyclylalkylpiperidine derivatives of general formula (II) for which R1, R'l, R'2, R'3, R'4 or R'5 represents an alkyloxymethyl or cycloalkyloxymethyl radical may be obtained by the action of the corresponding halo derivative (preferably the bromo derivative) on the corresponding heterocyclylalkylpiperidine derivative for which the radical R'i represents a hydroxymethyl radical. The reaction is generally carried out in an inert solvent such as an ether (for example tetrahydrofuran or dioxane), an amide (for example N,N-dimethylformamide) or dimethyl sulfoxide, in the presence of an acid acceptor such as a trialkylamine (for example triethylamine) or an alkali metal hydride (for example sodium hydride), at a temperature of between 20°C and lOO°C. The heterocyclylalkylpiperidine derivatives of general formula (II) for which R1, R'l, R'2, R'3, R'4 or R'5 represents a fluoromethyl radical may be obtained by the action of a fluorinating agent on the heterocyclylalkylpiperidine derivative for which the corresponding radical R'l represents a hydroxymethyl radical. The reaction may be carried out under the fluorinating conditions described above for the installation of a radical Re meaning fluorine. The heterocyclylalkylpiperidine derivatives of general formula (II) for which R1, R'l, R'2, R'3, R'4 or R's represents an alkylthiomethyl or cycloalkylthiomethyl radical may be obtained by the action of the corresponding thiol on a heterocyclylalkylpiperidine derivative for which the radical R'1 to be modified is halomethyl (halogen preferably being a bromine or chlorine atom). The reaction is generally carried out in an inert solvent such as an ether (for example tetrahydrofuran or dioxane), an amide (for example N,N-dimethylformamide) or dimethyl sulfoxide, in the presence of an acid acceptor such as a trialkylamine (for example triethylamine) or an alkali metal hydride (for example sodium hydride), at a temperature of between 2 0°C and the reflux temperature of the reaction mixture. The heterocyclylalkylpiperidine derivatives bearing a halomethyl radical R'l are prepared from the corresponding derivative for which R'1 is a hydroxymethyl radical by the action of a halogenating agent (halophosphorus derivative or thionyl chloride). The reaction is optionally carried out in an inert solvent such as dichloromethane, at a temperature of between 0°C and 60°C, optionally in the presence of a base such as pyridine- The heterocyclylalkylpiperidine derivatives of general formula (II) for which R1, R'l, R'2, R'3, R'4, or R's represents a radical -CH2-NRaRb may be obtained by the action of an amine HNRaRb on a heterocyclylalkylpiperidine derivative for which the radical R'i to be modified is halomethyl (the halogen preferably being a bromine or chlorine atom). The reaction is carried out in an inert solvent such as an ether (for example tetrahydrofuran or dioxane), an amide (for example N,N-dimethylformamide) or dimethyl sulfoxide, in the presence of an acid acceptor such as a trialkylamine (for example triethylamine) or an alkali metal hydride (for example sodium hydride), at a temperature of between 20°C and the reflux temperature of the reaction mixture. The halomethyl derivative is prepared as described above. The heterocyclylalkylpiperidine derivatives of general formula (II) for which R1, R'1, R'2, R'3, R'4, or R'5 represents a carboxymethyl radical may be obtained by the action of an alkaline cyanide on a heterocyclylalkyl-piperidine derivative for which the radical R'1 to be modified is halomethyl (the halogen preferably being a bromine or chlorine atom), followed by hydrolysis of the nitrile. The reaction is carried out using sodium cyanide or potassium cyanide in an organic solvent such as dimethyl sulfoxide or dimethylformamide, or in a water-alcohol mixture, at a temperature of between 0°C and the boiling point of the reaction mixture, followed by the action of a strong acid such as hydrochloric acid, optionally in the presence of a lower aliphatic alcohol, at a temperature of between O°C and the boiling point of the reaction mixture. The heterocyclylalkylpiperidine derivatives of general formula (II) for which R1, R'l, R'2, R'3, R'4, or R'5 represents an alkyloxycarbonylmethyl, cycloalkyloxy-carbonylmethyl or -CH2-C0-NRaRb radical may be obtained from the corresponding acid according to the usual methods for converting an acid to an ester or amide which do not affect the rest of the molecule, especially in the presence of a coupling agent such as a carbodiimide as described above. The heterocyclic derivatives of general formula (III) for which Hal is a bromine atom, R1 is defined as above, X1 to X4 represent, respectively, >C-R'1 to >C-R'4 and X5 represents >CH, may be prepared by brominating the corresponding 4-hydroxyquinolines using a brominating agent such as phosphorus oxitribromide or thionyl bromide without a solvent, at a temperature of between 20°C and 115°C. The 4-hydroxyquinolines may be prepared by decarboxylating the corresponding 3-carboxy-4-hydroxy-quinolines, working in a solvent such as diphenyl ether at a temperature of between lOO°C and 260°C. The 3-carboxy-4-hydroxyquinolines may be prepared by analogy with the method described in European patent application EP-A-0 379 412, starting with the desired aniline derivative. The heterocyclic derivatives of general formula (III) for which Hal is a bromine atom, R1 is defined as above, X1 to X4 represent, respectively, >C-R'1 to >C-R'4 and X5 represents >C-C1, may be prepared by brominating the corresponding 3-chloro-4-hydroxyquinoline. The bromination is generally carried out with triphenyl-phosphine dibromide in acetonitrile at a temperature of between 20°C and 85°C. The 3-chloro-4-hydroxyquinolines may be prepared by chlorinating a 4-hydroxyquinoline. The chlorination is carried out, for example, using N-chlorosuccinimide in a solvent such as acetic acid, at a temperature of between 20°C and lOO°C. The heterocyclic derivatives of general formula (III) for which Hal is a bromine atom, R1 is defined as above, X1 to X4 represent, respectively, >C-R'1 to >C-R'4 and X5 represents >C-C0CF3 may be prepared by analogy with the preparation of the derivatives for which X5 represents >CH, by brominating the corresponding 4-hydroxy-3-fluoroacetylquinoline derivative. The reaction is carried out without a solvent, using a brominating agent such as phosphorus oxytribromide, at a temperature of between 20°C and 115°C. The 4-hydroxy-3-trifluoro-acetylquinoline may be prepared by analogy with the method described for the preparation of 3-carboxy-4-hydroxyquinoline. The heterocyclic derivatives of general formula (III) for which Hal is an iodine atom, R1 is a methoxy radical, X1 to X4 represent, respectively, >C-R'1 to >C-R'4 and X5 represents >C-F, may be prepared by analogy with the studies of E. Arzel et al., Tetrahedron, 55, 12149-12156 (1999) starting with 3-fluoro-6-methoxy-quinoline, by the successive action of a base and then iodine. For example, lithium diisopropylamide in a solvent such as an ether (tetrahydrofuran) at-a temperature of between -80°C and 20°C is used. The 3-fluoro-6-methoxyquinoline may be obtained by pyrolysis of 6-methoxyquinoline diazonium 3-tetra-fluoroborate or 3-hexafluorophosphate according to the Balz-Schieman reaction, Org. Synth., Coll 5, 133 (1973), at a temperature of between lOO°C and 240°C. 6-Methoxy-quinoline diazonium 3-tetrafluoroborate or 6-methoxyquinoline diazonium 3-hexafluorophosphate may be obtained from 3-amino-6-methoxyquinoline by the action of an alkaline nitrite (for example sodium nitrite) in acidic medium (tetrafluoroboric acid or hexafluorophosphoric acid) in a solvent such as water at a temperature of between -lO°C and +20°C, by analogy with the studies of A. Roe et al., J. Am. Chem. Soc, 71, 1785-86 (1949) or by the action of an alkyl nitrite (such as, for example, isoamyl nitrite) and of the trifluoroborate/diethyl ether complex in a solvent such as an ether (for example tetrahydrofuran) at a temperature of between -10°C and +10°C. 3-Amino-6-methoxyquinoline is prepared as described by N. Heindel, J. Med. Chem. (1970) 13, 760. The heterocyclic derivatives of general formula (III) for which Hal is a bromine atom, Ri is defined as above, X2 to X4 represent, respectively, >C-R'2 to >C-R'4 and X1 represents a nitrogen atom or alternatively X1, X3, and X4 represent, respectively, >C-R'1, >C-R'3, and >C-R'4 and X2 represents a nitrogen atom, and X5 represents >CH or >C-C1, may be prepared by analogy with the methods described above when X1 to X4 represent, respectively, >C-R'1 to >C-R'4 or according to the syntheses described by Adams J.T. et al., J. Am. Chem. Soc, 68, 1317 (1946) for the 1,5-naphthyridines and S. Radl et al., Collect. Czech. Chem. Commun., 56, 2420 (1991) for the 1,7-naphthyridines, starting with 3-aminopyridines. The hydroxynaphthyridine required to carry out the reaction is also prepared by analogy with the methods described above for the hydroxyquinolines, but starting with 3-aminopyridine or its substituted derivatives. The 3-aminopyridine derivatives may be obtained by adaptation of the methods described in "The Chemistry of Heterocyclic Compounds", Vol. 14, Pyridines and its derivatives. Supplement Part III, page 41. Ed. R.A. Abramovitch, InterScience Publication. The heterocyclic derivatives of general formula (III) for which Hal is a bromine atom, R1 is defined as above, X1, X2, and X4 represent, respectively, >C-R'1, >C-R'2, and >C-R'4, X3 represents a nitrogen atom and X5 represents >CH or >C-C1, may be prepared by analogy with the methods described above when X, to X4 represent respectively, >C-R'1 to >C-R'4 or according to the syntheses described by D. Heber et al., Arzneim-Forsch, 44, 809 (1994) starting with 2-aminopyridines or substituted derivatives thereof. The 2-aminopyridines may be obtained by applying or adapting the methods described in "The Chemistry of Heterocyclic Compounds", Vol. 14, Pyridines and its derivatives. Supplement Part III, page 41. Ed. R. A. Abramovitch, Interscience Publication. The derivatives of general formula (III) for which Hal is a bromine atom, R1 is defined as above and X5 represents a nitrogen atom may be obtained from 2-amino- benzenamides as described in J. Am. Chem. Soc. , 69, 184 (1947). 2-Ainino-benzenamide is cyclized in the presence of an alkyl orthoformate such as ethyl orthoformate in a solvent such as diethylene glycol at a temperature of between 105°C and 120°C to give 4-hydroxyquinazoline, which is brominated as described above. The 2-amino-benzenamide is obtained from the corresponding aniline by applying or adapting the methods described by V. Snieckus, Chem. Rev., 90, 879 (1990) and Pure Appl. Chem. , 62, 2047 (1990) . The heterocyclic derivatives of general formula (III) for which Hal is a bromine atom, R1 is defined as above and X4 is a nitrogen atom may be obtained from 2- acetylaniline as described in Synth. Commun., 19, 3087 (1989). The 4-hydroxycinnoline obtained is brominated under the conditions described above. The 2-acetyl- anilines are obtained from the corresponding aniline by applying the methods cited above for 2-aminobenzenamide. The piperidine derivatives of general formula (IV) for which n = 0 and R"2 represents carboxyl may be prepared from the corresponding piperidine derivative of general formula: reaction between the piperidine derivative and vinyl phenyl sulfoxide in the presence of a base (for example sodium hydride, lithium diisopropylamide or lithium hexamethyldisyliylamide) in a solvent such as an ether (for example tetrahydrofuran) at a temperature of between O°C and lOO°C. The intermediate adduct obtained is then thermolyzed at between 60°C and 150°C in an inert solvent (for example chloroform, tetrahydrofuran, toluene or xylene). Rz is advantageously a protecting group for the nitrogen atom such as, for example, t-butyloxycarbonyl. The piperidine derivatives of general formula (IV) for which n = 1 or 2 and R"2 represents carboxyl may be prepared from the corresponding piperidine derivative of general formula (V) for which R"2 is protected beforehand, according to or by analogy with the methods described below in the examples. In particular, the process is performed by the successive action of a base such as, for example, lithium diisopropylamide or n-butyllithium, in a solvent such as an ether (for example tetrahydrofuran) at a temperature of between -80° C and O°C, and then of an alkenyl halide (allyl halide or l-halo-3-butene). The piperidine derivatives of general formula (IV) for which n is defined as above and R"2 is alkyloxycarbonyl, cycloalkyloxycarbonyl, -CO-NRaRb, alkyloxycarbonylmethyl, alkyloxycarbonylethyl, cycloalkyloxycarbonylmethyl, cycloalkyloxycarbonylethyl, -CH2-C0NRaRb, or - (CH2) 2-CONRaRb or for which Rc in R2 represents alkyloxycarbonyl, cycloalkyloxycarbonyl or -CO-NRaRb may be prepared from the corresponding carboxylic acid derivative, according to the usual methods for converting into ester or amide which do not affect the rest of the molecule- The esters are prepared in the presence of a coupling agent such as a carbodiimide (for example (N,N'-dicyclo[lacuna]-carbodiimide) or N,N'-carbonyldiimidazole in an ether (for example tetrahydrofuran or dioxane), an amide (for example dimethylformamide) or a chlorinated solvent (for example dichloromethane, 1,2-dichloroethane or chloroform), at a temperature of between 0°C and the reflux temperature of the reaction mixture. The amides are prepared by the action of the corresponding amine under conditions identical to those described above. In particular also, when it involves the preparation of a derivative for which Rc in R"2 is an ester, by analogy with the methods described by Saha et al., J. Chem. Soc. Perkin I, 505 (1985), by the action of a diazoalkane (for example diazomethane) in an ether (for example diethyl ether) at a temperature of between -lO°C and 5°C. The piperidine derivatives of general formula (IV) for which n is defined as above and R"2 represents cyano, -CH2-CN or -(CH2)2-CN may be prepared from the corresponding amides by the action of a dehydrating agent, by adapting the method described by Bieron et al., in which Rz and n are defined as above, and Ry represents a readily hydrolyzable protecting radical, in particular by the action of a hydride (for example lithium aluminum hydride or diisobutylaluminum hydride) in a solvent such as an ether (for example tetrahydrofuran) at a temperature of between 20°C and 60°C to prepare the piperidine derivative for which R"2 is hydroxymethyl, followed by converting the hydroxymethyl radical into a cyanomethyl radical and then a carboxymethyl radical according to the usual methods which do not affect the rest of the molecule. When Ry represents a readily hydrolysable radical, it may be chosen especially from alkyl (1 to 4 carbon atoms in a straight or branched chain), benzyl, cycloalkyl, phenylpropyl and allyl. The conversion into acid may be carried out in particular from the latter compound, by the action of a halogenating agent such as, for example, thionylchloride or phosphorus trichloride or tribromide or by the action of an alkanesulfonyl chloride (for example methanesulfonyl chloride or p-toluenesulfonyl chloride) in an inert solvent (for example dichloromethane), followed by the action of an alkaline cyanide (for example potassium cyanide or sodium cyanide) and hydrolysis. The halogenation reaction is carried out in a chlorinated solvent (for example dichloromethane or chloroform), at a temperature of between O°C and the reflux temperature of the reaction mixture. The reaction of the alkaline cyanide may be carried out in dimethyl sulfoxide, an amide (for example dimethylformamide), a ketone (for example acetone), an ether (for example tetrahydrofuran) or an alcohol (for example methanol or ethanol), at a temperature of between 20°C and the reflux temperature of the reaction mixture. The nitrile is hydrolyzed according to the conventional methods which do not affect the rest of the molecule, especially by the action of hydrochloric acid in methanolic medium, at a temperature of between 20°C and 70^C, followed by saponification of the ester obtained (for example with sodium hydroxide in a mixture of dioxane and water), or directly by the action of aqueous sulfuric acid at a temperature of between 50°C and 80^C. The piperidine derivatives of general formula (IV) for which n and Rz are defined as above and R"2 represents a 2-carboxyethyl radical may be prepared from the derivative of general formula (IV) for which R"2 represents a hydroxymethyl radical via the halo derivative (prepared as described above) and then coupling with the sodium salt of diethyl malonate followed by acidic hydrolysis in aqueous medium of the product obtained. The piperidine derivatives of general formula (IV) for which n and Rz are defined as above and R"2 represents carboxyhydroxymethyl or carboxycarbonyl may be prepared by homologation of the piperidine derivative of general formula: between -50°C and 10°C. The intermediate dicyanophosphate obtained is then hydrolyzed in acidic medium (for example concentrated hydrochloric acid) in a polar solvent (for example water) at the reflux temperature of the reaction mixture. The derivatives for which R"2 is carboxycarbonyl are obtained by oxidation of the corresponding ester, by adapting the methods described by Burhardt et al,, Tetrahedron Lett., 29, 3433 (1988) followed by hydrolysis of the product obtained. In particular by the action of an oxidizing agent such as triacetoxy-1,1-dihydro-l,2-benziodoxol-3(IH)one in a solvent such as a nitrile or a chlorinated derivative (for example acetonitrile or dichloromethane) at a temperature of between 0°C and 40°C, followed by hydrolysis by the action of a base (for example sodium hydroxide) in an aqueous-alcoholic solvent (for example water-methanol) at a temperature of between 20°C and the reflux temperature of the reaction mixture. The piperidine derivatives of general formula (IV) for which n and Rz are defined as above and R"2 represents -CF2-RC may be prepared by the action of a fluorinating agent on a piperidine derivative of general formula (IV) for which R"2 is a radical -CO-Rc, Rc being an ester, by analogy with the methods described by M. Parisi et al,, J. Org. Chem, 60, 5174 (1995), optionally followed by hydrolysis of the ester if it is desired to obtain a piperidine derivative for which Re is carboxyl. The fluorinating conditions are similar to those described above for the preparation of derivatives for which Re in Y is a fluorine atom. The hydrolysis is carried out by the action of a base in an aqueous-alcoholic solvent under the conditions described above. The piperidine derivatives of general formula (IV) for which n and Rz are defined as above and R"2 represents a radical -CH=CH-Rc may be prepared by oxidation to aldehyde of the derivative of general formula (TV) for which R"2 represents a hydroxymethyl radical by adapting the methods described in Org. Synth. Coll., Vol. II, p. 541, Coll. Vol. 5 p. 242 followed by conversion to a derivative for which R"2 is -CH=CH-Rc in which Re is an ester, by applying the Wittig method optionally followed by hydrolysis of the ester obtained to an acid. The oxidation is carried out by the action of an oxidizing agent (for example potassium dichromate) in acidic medium (for example sulfuric acid) in a polar solvent (for example water) or chromium oxide in the presence of a base (for example pyridine) in a chlorinated solvent (for example dichloromethane) at a temperature of between 0°C and 20°C. The conversion to an unsaturated derivative is carried out by adapting the methods described by Johnson in 'Ylid Chemistry" Academic Press (1966) by the action of a phosphorus ylid (for example carbethoxymethylenetriphenylphosphorane) in a hydrocarbon (for example toluene) at a temperature of between 60°C and the reflux temperature of the reaction mixture. The hydrolysis is carried out according to the methods described above. The piperidine derivatives of general formula (IV) for which n and Rz are defined as above and R"2 represents a radical C(CH3)2Rc or -C (cycloalk) Re may be prepared from a derivative of general formula (IV) for which R"2 is an ester of the acid for which R"2 is -CH2COOH by adapting the methods described by Ashutosh et al., Tetrahedron Lett., 40, 4733 (1999) and Sauers, J. Org. Chem. , 52/ 671 (1992) optionally followed by hydrolysis of the ester obtained. The reaction is carried out in particular by the successive action of an amide (for example lithium diisopropylamide) followed by a methyl halide (for example methyl iodide) or a derivative of formula Hal-Alk-Hal (Hal preferably being a bromine atom) in a polar solvent (for example hexamethylphosphorotriamide) at a temperature of between 0°C and 60°C. It is understood that the processes listed above for the preparation of the piperidine derivatives of general formula (IV) may also be applied to the derivatives of general formula (II) if it is preferred firstly to couple the piperidine with the heterocyclic derivative of general formula (III) and then to convert the radical R2 under the conditions described above. It is also understood that the methods described below in the examples also form part of the present invention. It is understood that the derivatives of general formulae (I) and (II) may exist in enantiomeric or diastereoisomeric forms or in syn or anti form. The enantiomeric or diastereoisomeric and syn or anti forms and the mixtures thereof also fall within the context of the present invention. These forms may be separated according to the usual methods, especially by chromatography on silica or by high performance liquid chromatography (HPLC). The heterocyclylalkylpiperidine derivatives of general formula (I) may be purified, where appropriate, by physical methods such as crystallization or chromatography. The heterocyclylalkylpiperidine derivatives of general formula (I) may, where appropriate, be converted into addition salts with acids, by the known methods. It is understood that these salts also fall within the context of the present invention. As examples of addition salts with pharmaceutically acceptable acids, mention may be made of the salts formed with mineral acids (hydrochlorides, hydrobromides, sulfates, nitrates and phosphates) or with organic acids (succinates, fumarates, tartrates, acetates, propionates, maleates, citrates, methanesulfonates, ethanesulfonates, phenylsulfonates, p-toluenesulfonates, isethionates, naphthylsulfonates or camphorsulfonates, or with substitution derivatives of these compounds). Some of the heterocyclylalkylpiperidine derivatives of general formula (I) bearing a carboxyl radical may be converted into metal salts or into addition salts with nitrogen bases according to the methods that are known per se. These salts also fall within the context of the present invention. The salts may be obtained by the action of a metallic base (for example an alkali metal or alkaline-earth metal), ammonia or an amine, on a product according to the invention, in a suitable solvent such as an alcohol, an ether or water, or by exchange reaction with a salt of an organic acid. The salt formed precipitates after optional concentration of the solution, and is separated out by filtration, settling or freeze-drying. Examples of pharmaceutically acceptable salts which may be mentioned are the salts with alkali metals (sodium, potassium or lithium) or with alkaline-earth metals (magnesium or calcium), the ammonium salts or the salts of nitrogen bases (ethanolamine, diethanolamine, trimethylamine, triethylamine, methylamine, propylamine, diisopropylamine, N-N-dimethylethanolamine, benzylamine, dicyclohexylamine, N-benzyl-P-phenethylamine, N,N'-dibenzylethylenediamine, diphenylenediamine. benzhydrylamine, quinine, choline, arginine, lysine, leucine or dibenzylamine). The heterocyclylalkylpiperidine derivatives according to the invention are particularly advantageous antibacterial agents. In vitro, the heterocyclylalkylpiperidine derivatives according to the invention have been found to be active on gram-positive microorganisms at concentrations of between 0.03 µg/ml and 4 µg/ml on meticillin-resistant Staphylococcus aureus AS5155, and also, for most of them, at concentrations of between 0.03 µg/ml and 8 µg/ml on Streptococcus pneumoniae 6254-01; they have also been found to be active on gram-negative microorganisms such as, for example, and in a nonlimiting manner, on Moraxella catarrhalis IPA 152, at concentrations of between 0.12 µg/ml and 64 µg/ml. In vivo, they have been found to be active on experimental infections of mice with Staphylococcus aureus IP8203, either subcutaneously at doses of between 18 mg/kg and 150 mg/kg {DC50) , or orally at doses of between 2 0 mg/kg and 150 mg/kg. Finally, the products according to the invention are particularly advantageous on account of their low toxicity. None of the products has shown any toxicity subcutaneously at the dose of 100 mg/kg in mice (2 administrations)• In the general formula (I), the products for which X1, X2, X3, X4 and X5 represent, respectively, >C-R'1 to >C-R'5, or alternatively not more than one of them represents a nitrogen atom, R1 R'l, R'2, R'3. -R'4 and R'5 are identical or different and represent a hydrogen or halogen atom or an alkyl or alkyloxy radical, or represent a methylene radical substituted with alkyloxy. R2 represents carboxyl, alkyloxycarbonyl or -CONRaRb (for which Ra represents a hydrogen atom and Rb represents a hydrogen atom or a hydroxyl radical) or R2 represents hydroxymethyl, alkyl containing 1 or 2 carbon atoms substituted with carboxyl or alkyloxycarbonyl , R3 represents a radical alk-R°3 for which alk is an alkyl radical and R°3 represents hydrogen, cycloalkyl, cycloalkylthio, phenyl, phenoxy, phenylthio, phenylamino, heterocyclyloxy or heterocyclylthio or alternatively R°3 represents -CR'b=CR'c-R'a for which R'a represents phenyl, and for which R'b and R'c represent hydrogen, Y represents a radical >CH-Re for which Re is hydrogen, fluoro or hydroxyl, n is an integer from 2 to 3, it being understood that the phenyl or heterocyclyl radicals or portions mentioned above may be optionally substituted on the ring with 1 to 4 halogens, are particularly advantageous. Especially the heterocyclylalkyl piperidine derivatives of general formula (I) mentioned below: • 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(thien-2-yl)thioethyl]piperidine-4-carboxylic acid • 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluorophenoxy)ethyl]piperidine-4-carboxylic acid • 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-(2-thiazol-2-thioethyl)piperidine-4-carboxylic acid • 1-(2-Cyclopentylthioethyl)-4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylic acid • 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-(3-phenylallyl)piperidine-4-carboxylic acid and also the salts thereof. Among the products according to the invention that may be more particularly mentioned are the heterocyclylalkylpiperidine derivatives of general formula (I), the names of which follow: 4- [3- (3-Chloro-6-methoxyquinolin-4-yl)propyl] -1-heptyl-piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[4-phenyl^ butyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[4-(2-fluorophenyl)propyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-l-[4-(3-fluorophenyl)propyl]piperidine-4-carboxylic acid 4- [3- (3-chloro-6-met}ioxyquinolin-4-yl)propyl] -1- [3- (4-fluorophenyl) propyl]piperidine-4-carboxylic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [4- (4-fluorophenyl)butyl]piperidine-4-carboxylic acid 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3-difluorophenyl)propyl]piperidine-4-carboxylic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [4- (2, 3-dif luorophenyl)propyl]piperidine-4-carboxylic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (2, 6-difluorophenyl)propyl]piperidine-4-carboxylic acid 4- [3- (3-Ctiloro-6-methoxyquinolin-4-yl)propyl] -1- [4- (2, 6-difluorophenyl)propyl]piperidine-4-carboxylic acid 4- [3- (3-Chloro-6-xnethoxyquinolin-4-yl)propyl] -1- [3- (3, 5-difluorophenyl)propyl]piperidine-4-carboxylic acid 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1- [3-(2,3,5-trifluorophenyl)propyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)propyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4"yl)propyl]-l-[3-(3,4,5-trifluorophenyl)propyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-phenyl-thiopropyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2-fluorophenylthio)propyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3-fluorophenylthio)propyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(4- fluorophenylthio)ethyl]piperidine-4-carboxylic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (4- fluorophenylthio)propyl]piperidine-4-carboxylic acid 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2, 3- difluorophenylthio)ethyl]-piperidine-4-carboxylic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (2,3- difluorophenylthio)propyl] -piperidine-4-carboxylic acid 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-!-[2-(2,6- dif luoroptienylthio) ethyl] -piperidine-4-carboxylic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,3,5- trifluorophenylthio)ethyl]-piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6- trifluorophenylthio)ethyl]-piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5- trifluorophenylthio)ethyl]-piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,3,5- trifluorophenoxy)ethyl]-piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6- trifluorophenoxy)ethyl]-piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5- trifluorophenoxy)ethyl]-piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5- difluorophenylamino)ethyl]-piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,3,5- trifluorophenylamino)ethyl]-piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,4,6-trifluorophenylamino)ethyl]-piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-l-[2-(3,4,5-trifluorophenylainino)ethyl]-piperidine-4-carboxylic acid 4-[3-{3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,6-difluorophenylthio)propyl]-piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2-chlorophenylthio)ethyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2-chlorophenylthio)propyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3-chlorophenylthio)ethyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3-chlorophenylthio)propyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(4-chlorophenylthio)ethyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(4-chlorophenylthio)propyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2-methylphenylthio)ethyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2-methylphenylthio)propyl] -piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3-methylphenylthio)ethyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3-methylphenylthio)propyl]-piperidine-4-carboxylic acid 4- [3- (3-Chloro-6-methoxyquinolin-4-yl)propyl]-l- [2- (4-methylphenylthio) ethyl]piperidine-4-carboxylic acid 4- [3- (3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (4-methylphenylthio)propyl] -piperidine-4-carboxylic acid 4- [3- (3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- [2- (2-trif luoromethylphenylthio) ethyl] -piperidine-4-carboxylic acid 4- [3- (3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (2-trifluoromethylphenylthio)propyl]-piperidine-4-carboxylic acid 4- [3- (3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- [2- (3-trifluoromethylphenylthio)ethyl]-piperidine-4-carboxylic acid 4-[3-{3-Chloro-6-methoxyquinolin-4-yl)propyl]-!-[3-(3-trif luoromethylphenylthio) propyl]-piperidine-4-carboxylic acid 4- [3- (3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- [2- (4-trif luoromethylphenylthio) ethyl] -piperidine-4-carboxylic acid 4- [3- (3-Chloro-6-methoxyquinolin-4-yl)propyl]-l- [3- (4-trif luoromethylphenylthio)propyl] -piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2-methoxyphenylthio)ethyl]-piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2-methoxyphenylthio)propyl]-piperidine-4-carboxylic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [2- (3-methoxyphenylthio) ethyl] -piperidine-4-carboxylic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (3-methoxyp]ienylt]iio)propyl] -piperidine-4-carboxylic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [2- (4-methoxyphenylthio) ethyl]piperidine-4-carboxylic acid 4- [3- (3-Chloro-6-mettaoxyquinolin-4-yl)propyl] -1- [3- (4-methoxyphenylthio)propyl] -piperidine-4-carboxylic acid 4- [3- {3-chloro-6-methoxyquinolin-4-yl)propyl] -1-[cyclopentylmethyl]piperidine-4-carl3oxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(cyclopentyl) ethyl]piperidine-4-carboxylic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [2-(cyclopentylthio) ethyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(cyclopentylthio)propyl]piperidine-4-carboxylic acid 4- [3- (3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- [3-(cyclo]lexylt]lio)propyl]piperidine-4-carboxylic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [4- (thien-2-yl)butyl]piperidine-4-carboxylic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (thien-2-yl) thiopropyl] piperidine-4-carboxylic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (thien-3-yl)propyl]piperidine-4-carboxylic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [4- {thien-3-yl)butyl]piperidine-4-carboxylic acid 4- [3- (3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- [2- (thien-3- yl)thioethyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(thien-3- yl)thiopropyl]piperidine-4-carboxylic acid 4-[3-{3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(1,3- thiazol-2-yl)propyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyguinolin-4-yl)propyl]-1-[4-(1,3- thiazol-2-yl)butyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(1,3- th.iazol-2-yl)thioethyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(pyrid-2- yl)propyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[4-(pyrid-2- yl)butyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyguinolin-4-yl)propyl]-1-[3-(pyrid-2- yl)thiopropyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(pyrid-3- yl)propyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[4-(pyrid-3- yl)butyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-6^methoxyquinolin-4-yl)propyl]-1-[2-(pyrid-3- yl)thioethyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(pyrid-3- yl)thiopropyl]piperidine^4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(pyrid-4- yl)propyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[4-(pyrid-4- yl)butyl]piperidine-4-carboxylic acid 4-[3-{3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(pyrid-4- yl)thioethyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(pyrid-4- yl)thiopropyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(pyrazin- 2-yl)propyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[4-(pyrazin- 2-yl)butyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(pyrazin- 2-yl)thioethyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(pyrazin- 2-yl)thiopropyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(4- fluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4- difluorop}ienyl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -l-[3-(2,4- difluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5- trifluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-l-[3-(2,4,6- trifluorophenyl)prop-2-ynyl]piperidine^4-carboxylic acid 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-!-[3-(3,4,5- trifluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(4-chloro-3-fluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- (3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (3-chloro-4-fluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-{3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2-chloro-4-fluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- {3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (3-chloro-5-f luorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- {3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (4-chloro-2-f luorophenyl) prop-2-ynyl ] piperidine-4-carboxylic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (3-fluoro-4-methylphenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-5-methoxyquinolin-4-yl)propyl]-l-[3-(3,5-bis (trif luoroInethyl)pllenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- {3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (thien-2-yl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyll -1- [3- (thien-3-yl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(1,3-t]iiazol-2-yl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-{3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(1,3- thia2ol-4-yl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(1,3- thiazol-5-yl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-{3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(pyrid-2- yl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-5-methoxyquinolin-4-yl)propyl]-1-[3-{pyrid-3- yl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(pyrid-4- yl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[2- (cyclotiexyl) ethyl]piperidine-4-carboxylic acid 4- [3- {3-Methyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (phenyl)propyl]piperidine-4-carboxylic acid 4- [3- (3-methyll-6-methoxyquinolin-4-yl)propyl]-!- [3- (2,3, 5- trifluorophenyl)propyl]piperidine-4-carboxylic acid 4- [3- (3-Methyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (3, 5- dif luorophenylamino) ethyl] -piperidine-4-carboxylic acid 4- [3- (3-Methyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,3,5- trif luorophenylamino) ethyl] -piperidine-4-carboxylic acid 4- [3- (3-methyll-6-methoxyquinolin-4-yl)propyl] -1- [2- (3,5- dif luorophenoxy) ethyl] -piperidine-4-carboxylic acid 4- [3- (3-Methyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,3,5- trifluorophenoxy)ethyl]-piperidine-4-carboxylic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[2- (cyclopentylthio)ethyl]piperidine-4-carboxylic acid 4- [3- {3-Methyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (pyrid-2- yl)thioethyl]piperidine-4-carboxylic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(thien-2- yl)thioethyl]piperidine-4-carboxylic acid 4-[3-(3-Methyl-6-xnethoxyquinolin-4-yl)propyl]-1-[3-(2,3,5- trifluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-!-[3-(thien-2- yl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5- trifluorophenyl) propyl] piperidine-4-carboxylic acid 4- [3- (3-Fluoro-6-methoxyquinolin-4-yl)propyl] -1- [2- (3, 5- difluorophenylamino) ethyl]piperidine-4-carboxylic acid 4- [3- (3-Fluoro-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,3,5- trifluorophenylamino) ethyl]piperidine-4-carboxylic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5- difluorophenoxy)ethyl]piperidine-4-carboxylic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,3,5- trifluorophenoxy) ethyl]piperidine-4-carboxylic acid 4- [3- (3-Fluoro-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,3,5- trifluorophenylttiio)ethyl]piperidine-4-carboxylic acid 4- [3- (3-Fluoro-6-methoxyquinolin-4-yl)propyl] -1- [2- (pyrid-2- yl) thieothyl]piperidine-4-carboxylic acid 4- [3- (3-Fluoro-6-methoxyquinolin-4-yl)propyl] -1- [3- (2,3,5- trifluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(3-Fluoro-6-methoxyqainolin-4-yl)propyl]-1-[3-(thien-2- yl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- (3-Diinethylarnino-6-methoxyquinolin-4-yl)propyl] -1- [2- (cyclohexyl) ethyl]piperidine-4-car3DOxylic acid 4- [3- (3-Dimethylaxnino-6-methoxyquinolin-4-yl)propyl] -1- [3- (phenyl)propyl]piperidine-4-carboxylic acid 4- [3- {3-Dimethylainino-6-methoxyquinolin-4-yl)propyl] -1- [3- (2,3,5-trifluorophenyl)propyl]piperidine-4-carboxylic acid 4- [3- (3-Dimethylainino-6-methoxyquinolin-4-yl)propyl] -1- [2- (3,5-difluorophenylamino)ethyl]piperidine-4-carboxylic acid 4-[3-{3-Dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[2- {2,3,5-trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4- [3- (3-Dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [2- (3,5-difluorophenoxy)ethyl]piperidine-4-carboxylic acid 4-[3-(3-Dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[2- (2 ,3,5-trifluorophenoxy)ethyl]piperidine-4-carboxylic acid 4- [3- (3-Dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [2- (2 ,3,5-trifluorophenylthio)ethyl]piperidine-4-carboxylic acid 4- [3- (3-Dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [2- (cyclopentylthio)ethyl]piperidine-4-carboxylic acid 4- [3- (3-Dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [2- (pyrid-2-yl) thioethyl]piperidine-4-carboxylic acid 4- [3- (3-Dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [2- (thien-2-yl) thioethyl]piperidine-4-carboxylic acid 4- [3- (3-Dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [3- (2,3, 5-trif luorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- (3-Dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [3-(thien-2-yl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(cyclohexyl)ethyl]piperidine-4-carboxylic acid 4-[3-(3-Hydroxymethyl-5-methoxyquinolin-4-yl)propyl]-1-[3-(phenyl)propyl]piperidine-4-carboxylic acid 4- [3- (3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl] -1- [3-(2,3,5-trifluorophenyl)propyl]piperidine-4-carboxylic acid 4- [3- (3-Hydroxymethyl--6-methoxyquinolin-4-yl)propyl] -1- [2-(3 , 5-difluorophenylamino) ethyl ]piperidine-4-carboxylic acid 4- [3- (3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl] -1- [2-(2,3,5-trifluorophenylainino)ethyl]piperidine-4-carboxylic acid 4- [3- (3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl] -1- [2-(3,5-difluorophenoxy)ethyl]piperidine-4-carboxylic acid 4-[3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenoxy)ethyl]piperidine-4-carboxylic acid 4-[3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenylthio)ethyl]piperidine-4-carboxylic acid 4- [3- (3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl] -1- [2-(cyclopentylthio)ethyl]piperidine-4~carboxylic acid 4- [3- (3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl] -1- [2-(pyrid-2-yl) thioethyl]piperidine-4-carboxylic acid 4- [3- (3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl] -1- [2-(thien-2-yl)thioethyl]piperidine-4-carboxylic acid 4-[3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2, 3, 5-trifluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- (3-Hydroxymethyl-6-met]:ioxyquinolin-4-yl)propyl] -1- [3-(t]iien-2-yl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- (3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl] -1- [2-(cyclohexyl) ethyl]piperidine-4-carboxylic acid 4- [3- (3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl] -1- [3-(phenyl) propyl]piperidine-4-carboxylic acid 4- [3- (3-Fluoromethyll-6-methoxyquinolin-4-yl)propyl] -1- [3-(2,3,5-trifluorophenyl)propyl]piperidine-4-carboxylic acid 4- [3- (3-Fluoromethyll-6-methoxyquinolin-4-yl)propyl] -1- [2-(3, 5-dif luorophenylamino)ethyl]piperidine-4-carboxylic acid 4- [3- (3-Fluoromethyl-6-met]aoxyquinolin-4-yl)propyl] -1- [2-(2,3, 5-trif luorophenylamino) ethyl]piperidine-4-carboxylic acid 4- [3- (3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-l-[2-(3 , 5-dif luorophenoxy) ethyl]piperidine-4-carboxylic acid 4- [3- (3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl] -1- [2-(2,3,5-trifluorophenoxy)ethyl]piperidine-4-carboxylic acid 4- [3- (3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl] -1- [2-(2,3, 5-trif luorophenylthio) ethyl]piperidine-4-carboxylic acid 4- [3- (3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl] -1- [2-(cyclopentylthio) ethyl]piperidine-4-carboxylic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(pyrid-2-yl)thioethyl]piperidine-4-carboxylic acid 4- [3- (3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (thien-2-yl) thioethyl]piperidine-4-carboxylic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[3- (2,3,5-trifluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- (3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (thien-2-yl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- (3-Aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (cyclohexyl)ethyl]piperidine-4-carboxylic acid 4- [3- (3-Aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (phenyl)propyl]piperidine-4-carboxylic acid 4- [3- (3-Amnomethyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (2,3,5-trifluorophenyl)propyl]piperidine-4-carboxylic acid 4- [3- (3-Aminomethyl-6-methioxyquinolin-4-yl)propyl] -1- [2- (3, 5-dif luorophenylamino)ethyl]piperidine-4-carboxylic acid 4- [3- (3-Aminoxnethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,3,5-trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4- [3- (3-Aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (3, 5-dif luorophenoxy) ethyl]piperidine-4-carboxylic acid 4- [3- (3-Aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,3,5-trifluorophenoxy)ethyl]piperidine-4-carboxylic acid 4-[3-(3-Aniinomethyl-6-methoxyquinolin-4-yl)propyl]-l-[2- (2,3,5-trifluorophenylthio)ethyl]piperidine-4-carboxylic acid 4- [3- (3-Aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (cyclopentylthio) ethyl] piperidine-4-carboxylic acid 4-[3-(3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2- (pyrid-2-yl)thioethyl]piperidine-4-carboxylic acid 4-[3-(3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2- (thien-2-yl)thioethyl]piperidine-4-carboxylic acid 4- [3- (3-aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (2,3, 5-trif luorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- (3-Aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (thien-2-yl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- (3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2-(cyclohexyl)ethyl]piperidine-4-carboxylic acid 4-[3-(3-Morpholinoinethyl-6-methoxyquinolin-4-yl)propyl]-1- [3-(phenyl)propyl]piperidine-4-carboxylic acid 4-[3-(3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1- [3-(2,3,5-trifluorophenyl)propyl]piperidine-4-carboxylic acid 4- [3- (3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2-(3,5-difluorophenylamino)ethyl]piperidine-4-carboxylic acid 4- [3- (3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2-(2,3,5-trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4- [3- (3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2-(3,5-difluorophenoxy)ethyl]piperidine-4-carboxylic acid 4-[3-(3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1- [2-(2,3,5-trifluorophenoxy)ethyl]piperidine-4-carboxylic acid 4- [3- (3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,3, 5-trifluorophenylthio)ethyl]piperidine-4-carboxylic acid 4- [3- (3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2-(eye1opentylthio)ethyl]piperidine-4-carboxylic acid 4-[3-(3-Morpholinoinethyl-6-methoxyquinolin-4-yl)propyl]-1- [2-(pyrid-2-yl)thioethyl]piperidine-4-earboxylic acid 4-[3-(3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1- [2-(thien-2-yl)thioethyl]piperidine-4-carboxylic acid 4-[3-(3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1- [3-(2,3,5-trifluorophenyl)prop-2-ynyl]piperidine-4- carboxylic acid 4-[3-(3-Morpholinoinethyl-6-methoxyquinolin-4-yl)propyl]-1- [3-(thien-2-yl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6- trifluorophenyl)propyl]piperidine-4-carboxylic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5- trifluorophenyl)propyl]piperidine-4-carboxylic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6- trifluorophenylthio)ethyl]piperidine-4-carboxylic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5- trifluorophenylthio)ethyl]piperidine-4-carboxylic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6- trifluorophenylainino)ethyl]piperidine-4-carboxylic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5- trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4- [3- (3-Methyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,4,6- trifluorophenoxy)ethyl]piperidine-4-carboxylic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-l-[2-(3,4,5- trifluorophenoxy)ethyl]piperidine-4-carboxylic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6- trifluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[3- (3,4,5- trifluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- (3-Fl-uoro-6-methoxyquinolin-4-yl) propyl] -l-[3-(2,4,6- trifluorophenyl)propyl]piperidine-4-carboxylic acid 4-[3-{3-Fluoro-6-methoxyquinolin-4-yl)propyl]-l-[3-(3,4,5- trifluorophenyl)propyl]piperidine-4-carboxylic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6- trifluorophenylthio)ethyl]-piperidine-4-carboxylic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5- trifluorophenylthio)ethyl]-piperidine-4-carboxylic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,4,6- trifluorophenylamino)ethyl]-piperidine-4-carboxylic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5- trifluorophenylamino)ethyl]-piperidine-4-carboxylic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6- trifluorophenoxy)ethyl]-piperidine-4-carboxylic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5- trifluorophenoxy)ethyl]-piperidine-4-carboxylic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6- trifluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-l-[3-(3,4,5-trifluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(3-Dimethylainino-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)-propyl]piperidine-4-carboxylic acid 4- [3- (3-Dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [3-(3,4,5-trifluorophenyl)-propyl]piperidine-4-carboxylie acid 4-[3-(3-Dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenylthio)-ethyl]piperidine-4-carboxylic acid 4- [3- (3-Dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [2-(3,4,5-trifluorophenylthio)-ethyl]piperidine-4-carboxylic acid 4- [3- (3-Dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [2-(2,4, 6-trif luorophenylamino) -ethyl] -piperidine-4-carboxylic acid 4- [3- (3-Diinethylamino-6-methoxyquinolin-4-yl)propyl] -1- [2-(3,4,5-trifluorophenylamino)-ethyl]piperidine-4-carboxylic acid 4- [3- (3-Dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [2-(2,4, 6-trif luorophenoxy) -ethyl] piperidine-4-carboxylic acid 4- [3- (3-Dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [2-(3,4,5-trifluorophenoxy)-ethyl]piperidine-4-carboxylic acid 4- [3- (3-Dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [3-(2,4,6-trifluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(3-Dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-LB-IB, 4, 5-trifluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [B- (B-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl] -1- [B- (3,4, 5-trif luorophenyl)propyl]piperidine-4-carboxylic acid 4- [3- (3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,4, 6-trifluorophenylthio) ethyl]piperidine-4-carboxylic acid 4- [3- (3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (3,4, 5-trifluorophenylthio) ethyl]piperidine-4-carboxylic acid 4- [3- (3-Hydroxymethyll-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,4, 6-trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4- [3- (3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (3,4, 5-trif luorophenylamino)ethyl]piperidine-4-carboxylic acid 4- [3- (3-HydroxyTnethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,4,6-trifluorophenoxy)-ethyl]piperidine-4-carboxylic acid 4- [3- (3-HydroxyTnethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (3,4,5-trifluorophenoxy)-ethyl]piperidine-4-carboxylic acid 4-[3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[3- (2,4,6-trifluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- (B-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (3,4,5-trifluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)propyl]piperidine-4-carboxylic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)propyl]piperidine-4-carboxylic acid 4-[3-(3-Fluoromethyl-6-methoxyqainolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenylthio)ethyl]piperidine-4-carboxylic acid 4- [3- (3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl] -1- [2-(3,4, 5-trifluorophenylthio) ethyl] -piperidine-4-carboxylic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenylamino)-ethyl]piperidine-4-carboxylic acid 4- [3- (3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl] -1- [2-(3,4,5-trifluorophenylamino)-ethyl]piperidine-4-carboxylic acid 4- [3- (3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl] -1- [2-(2,4,6-trifluorophenoxy)-ethyl]piperidine-4-carboxylic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenoxy)-ethyl]piperidine-4-carboxylic acid 4- [3- (3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl] -1- [3-(2,4, 6-trif luorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- (3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-1- [3- (2,4,6-trifluorophenyl)propyl]piperidine-4-carboxylic acid 4- [3- (3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-l- [3- (3,4,5-trifluorophenyl)propyl]piperidine-4-carboxylic acid 4- [3- (3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-l- [2- (2, 4, 6-trifluorophenylthio)ethyl]piperidine-4-carboxylic acid 4- [3- {3-Aininomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (3,4, 5-trifluorophenylthio) ethyl]piperidine-4-carboxylic acid 4- [3- (3-Aminomethyl-6-iuethoxyquinolin~4-yl)propyl]-l- [2- (2,4, 6-trif luoroptienylairiino) ethyl]piperidine-4-carboxylic acid 4- [3- (3-Aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (3,4, 5-trif luorophenylamino) ethyl]piperidine-4-carboxylic acid 4- [3- (3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-l- [2- (2, 4, 6-trif luorophenoxy)ethyl]piperidine-4-carboxylic acid 4- [3- (3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-!- [2- (3,4, 5-trif luorophenoxy)ethyl]piperidine-4-carboxylic acid 4- [3- (3-Aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (2,4, 6-trif luorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- (3-Aminoxnethyl-6-inethoxyquinolin-4-yl)propyl] -1- [3- (3,4,5-trifluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- {3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1-[3-(2,4,5-trifluorophenyl)-propyl]piperidine-4-carboxylic acid 4- [3- (3~Morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1-[3-(3,4,5-trifluorophenyl)-propyl]piperidine-4-carboxylic acid 4- [3- (3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1-[2- (2, 4, 6-trifluorophenylthio) -ethyl]piperidine-4-carboxylic acid 4- [3- (3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1-[2- (3, 4, 5-trif luorophenylthio) -ethyl]piperidine-4-carboxylic acid 4- [3- (3-Morpholinoxnethyl-6-methoxyquinolin-4-yl)propyl] -1-[2- (2,4, 6-trifluorophenylainino) ethyl ]piperidine-4-carboxylic acid 4- [3- (3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1-[2- (3,4, 5-trif luorophenylamino) ethyl]piperidine-4-carboxylic acid 4- [3- {3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1-[2-(2,4,6-trifluorophenoxy)-ethyl]piperidine-4-carboxylic acid 4- [3- (3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4-carboxylic acid 4- [3- (3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1-[3-(2,4,6-trifluorophenyl)-prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- (R, S)-Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (2, 6-dif luorophenyl)propyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[4-(2,6-difluorophenyl)propyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,5-difluorophenyl)propyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)propyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-phenylthio-propyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (2-f luorophenylthio)propyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl)propyl]-l-[3-(3-fluorophenylthio)propyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-{3-chloro-6-methoxyquinolin-4-yl)propyl]-l- [2- (4-fluorophenylthio) etllyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl)propyl]-l-[3-(4-fluorophenylthio)propyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3-difluorophenylthio)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yDpropyl] -1- [3- (2, 3-dif luorophenylthio)propyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,6-difluorophenylthio)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [2- (2, 3, 5-trifluorophenyltliio) ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenylthio)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenylthio)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluorophenoxy)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-!-[2-(2,3,5-trifluorophenoxy)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenoxy)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [2- (3, 5-dif luorophenylamino) ethyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[2-(2,3,5- trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[2-(2,4,6- trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[2-(3,4,5- trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-{3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,6-difluorophenylthio)propyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(2-chlorophenylthio)ethyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Hydroxy-3-{3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(2-chlorophenylthio)propyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(3-chlorophenylthio)ethyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(3-chlorophenylthio)propyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(4-chlorophenylthio)ethyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yl) propyl] -1- [3- (4-c]nlorophenylthio)propyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [2- {2-methylphenylthio)ethyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-5-methoxyquinolin-4- yl)propyl]-1-[3-(2-methylphenylthio)propyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(3-methylphenylthio)ethyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-{3-methylphenylthio)propyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [2- {4-methylphenylthio) ethyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Hydroxy-3-{3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [3- (4-methylphenylthio)propyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[2-{2- trifluoromethylphenylthio)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[3-(2- trifluorome thyIphenylthio)propyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[2-(3- trifluoromethylphenylthio)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[3-(3- trifluoromethylphenylthio)propyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[2-(4- trifluoromethylphenylthio)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-{3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[3-(4- trifluoromethyIphenylthio)propyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- {3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[2-(2-methoxyphenylthio)ethyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(2-methoxyphenylthio)propyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Hydroxy-3- {3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(3-methoxyphenylthio)ethyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [3- (3-methoxyphenylthio)propyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(4-methoxyphenylthio)ethyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(4-methoxyphenylthio)propyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-inethoxyquinolin-4- yl)propyl] -1- [cyclopentylmet]ayl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(cyclopentyl)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [2- (cyclohexyl) ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [2- (cyclopentylthio) ethyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [3- {cyclopentylthio)propyl]piperidine-4- carboxylic acid 4-[3-{R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(cyclohexylthio)propyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-{pyrid-2-yl)thioethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yDpropyl] -1- [4- (thien-2-yl)butyl]piperidine-4-carboxylic acid 4- [3- (R,S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (thien-2-yl) thiopropyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(thien-3-yl)propyl]piperidine-4-carboxylic acid 4- [3- (R,S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yDpropyl] -1- [4- {thien-3-yl)butyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-l-[2-(thien-2-yl)thioethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [2- (thien-3-yl) thioethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (thien-3-yl) thiopropyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-!-[3-(1,3-thiazol-2-yl)propyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl) propyl]-!- [4- (!, 3-thiazol-2-yl)butyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-5-methoxyquinolin-4- yl)propyl] -1- [3- (1, 3-thiazol-2-yl) thioethyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Hydroxy-3-{3-chloro-6-methoxyquinolin-4- yl)propyl]-!-[3-(pyrid-2-yl)propyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [4- {pyrid-2-yl)butyl]piperidine-4-carboxylic acid 4- [3- (R,S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yl) propyl] -1- [3- (pyrid-2-yl) thiopropyl] piperidine-4- carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(pyrid-3-yl)propyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- {3-chloro-6-methoxyquinolin-4- yl)propyl]-!-[4-{pyrid-3-yl)butyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [2- (pyrid-3-yl) thioethyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(pyrid-3-yl)thiopropyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- {3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-{pyrid-4-yl)propyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) propyl] -1- [4- (pyrid-4-yl)butyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-c]iloro-6-methoxyquinolin-4-yl) propyl] -1- [2- (pyrid-4-yl) thioetllyl]piperidine-4-carboxylic acid 4- [3- (R,S)-Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (pyrid-4-yl) thiopropyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(pyrazin-2-yl)propyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- {3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[4-{pyrazin-2-yl)butyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yDpropyl] -1- [2- (pyrazin-2-yl) thioethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- {3-chloro-6-methoxyquinolin-4-yDpropyl] -1- [3- {pyrazin-2-yl) thiopropyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yDpropyl]-1- [3- (4-fluorophenyl)prop-2-ynyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [3- (3, 4-dif luorophenyl)prop-2-ynyl]piperidine- 4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,4-difluorophenyl)prop-2-ynyl]piperidine- 4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[3-(2,3,5-trifluorophenyl)prop-2- ynyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-l- [3- (2,4, 6-trifluorophenyl)prop-2- ynyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [3- (3, 4, 5-tr if luorophenyl) prop-2- ynyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(4-chloro-3-fluorophenyl)prop-2- ynyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(3-chloro-4-fluorophenyl)prop-2- ynyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(2-chloro-4-fluorophenyl)prop-2- ynyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yDpropyl] -1- [3- (3-chloro-5-f luorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) propyl] -1- [3- (4-chloro-2-f luoropllenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yDpropyl] -1- [3- (3-f luoro-4-methylp]ienyl)prop-2-ynyl]piperidine-4-carlx)xylic acid 4- [3- (R, S) -Hydroxy-3- {3-chloro-6-methoxyquinolin-4-yl)propyl]-!- [3- (3, 5-bis(trifluoromethyl)phenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- (R,S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (thien-2-yl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- {thien-3-yl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-!-[3-(1,3-tllia2ol-2-yl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- (R,S) -Hydroxy-3- {3-chloro-6-methoxyquinolin-4-yDpropyl] -1- [3- (!, 3-thia2ol-4-yl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-{3-chloro-6-methoxyquinolin-4-yDpropyl] -1- [3- (1, 3-thia2ol-5-yl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(pyrid-2-yl)prop-2-ynyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Hydroxy-3-{3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(pyrid-3-yl)prop-2-ynyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(pyrid-4-yl)prop-2-ynyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-methyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(cyclohexyl)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-methyl-6-methoxyquinolin-4- yl)propyl]-1-[3-(phenyl)propyl]piperidine-4-carboxylic acid 4-[3-(R/S)-Hydroxy-3-(3-methyl-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,3,5-trifluorophenyl)propyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-methyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,5-difluorophenylamino)ethyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-methyl-6-methoxyquinolin-4- yl)propyl]-l-[2-(2,3,5- trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-methyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,5-difluorophenoxy)ethyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-methyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (2, 3, 5-trif luorophenoxy)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-methyl-6-methoxyquinolin-4-yDpropyl] -1- [2- (2, 3, 5-trif luorophenylthio) ethyl] piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- {3-methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(cyclopentylthio)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(pyrid-2-yl)thioethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-{3-methyl-6-methoxyquinolin-4-yDpropyl] -1- [2- (thien-2-yl) thioethyl]piperidine-4-carboxylic acid 4- [3- (R/S) -Hydroxy-3- (3-methyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (2, 3, 5-trifluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-{3-methyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(thien-2-yl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(cyclohexyl)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yDpropyl] -1- [3- (phenyl)propyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-f luoro-6-methoxyquinolin-4-yDpropyl] -1- [3- (2,3, 5-trif luorophenyl)propyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-f luoro-6-methoxyquinolin-4-yl)propyl] -1- [2- (3, 5-dif luorophenylamino) ethyl] piperidine-4-carlboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-f luoro-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,3,5- trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-f luoro-6-methoxyc[uinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenoxy)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-raethoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenylthio)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yDpropyl] -1- [2- (cyclopentylthio) ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(pyrid-2-yl)thioethyl]piperidine-4-carboxylic acid 4- [3- (R,S)-Hydroxy-3- (3-f luoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(thien-2-yl)thioethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-!-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-{3-fluoro-6-methoxyquinolin-4- yl)propyl]-1-[3-(thien-2-yl)prop-2-ynyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-dimethylamino-6-methoxyquinolin-4- yl)propyl]-l-[2-(cyclohexyl)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-dimethylamino-6-methoxyquinolin-4- yDpropyl] -1- [3- {phenyl)propyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-dimethylamino-6-methoxyquinolin-4- yl)propyl]-!-[3-(2,3,5-trifluorophenyl)propyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-dimethylamino-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,5-difluorophenylamino)ethyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-dimethylarnino-6-methoxyquinolin-4- yl)propyl]-l-[2-(2,3,5- trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-dimethylamino-6-methoxyquinolin-4- yDpropyl] -1- [2- (3, 5-dif luorophenoxy) ethyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-diinethylamino-6-methoxyquinolin-4- yl)propyl] -1- [2- (2,3, 5-trif luorophenoxy) ethyl ] piper idine-4- carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-dimethylamino-6-methoxyquinolin-4- yDpropyl] -1- [2- (2,3, 5-trif luorophenylthio) ethyl ]piperidine- 4-carboxylic acid 4- [3- (R,S) -Hydroxy-3- (3-dimethylamino-6-methoxyquinolin-4- yl)propyl]-1-[2-(cyclopentylthio)ethyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-dimethylamino-6-methoxyquinolin-4- yl)propyl]-1-[2-(pyrid-2-yl)thioethyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-dimethylamino-6-methoxyquinolin-4- yl)propyl]-1-[2-(thien-2-yl)thioethyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-dimethylamino-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,3,5-trifluorophenyl)prop-2- ynyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-dimethylainino-6-methoxyquinolin-4- yl)propyl]-1-[3-(thien-2-yl)prop-2-ynyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-hydroxymethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(cyclohexyl)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-Hydroxymethyl-6-methoxyquinolin-4- yl)propyl]-1-[3-(phenyl)propyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-hydroxymethyl-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,3,5-trifluorophenyl)propyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-hydroxymethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,5-difluorophenylamino)ethyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,3,5- trif luorophenylamino) ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-liydroxymethyl-6-methoxyquinolin-4-yl) propyl] -1- [2- (3, 5-dif luorophenoxy) et]lyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-hydroxymnethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenoxy)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenylthio)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(cyclopentylthio)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-{pyrid-2-yl)thioethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-{thien-2-yl)thioethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(thien-2-yl)prop-2-ynyl]piperidine-4-carboxylic acid i-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-,l) propyl]-1- [2- (cyclohexyl) ethyl]piperidine-4-carboxylic icid I- [3- (R, S) -Hydroxy-3- (3-f luoromethyl-6-methoxyquinolin-4-,'l)propyl] -1-[3-(phenyl)propyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (2, 3, 5-trifluorophenyl)propyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoroinethyl-6-methoxyquinolin-4-yl)Dpropyl]-!- [2- (3, S-difluorophenylamino)ethyl]piperidine-4-parboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoroinethyl-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,3,5- brifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluorophenoxy)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-f luoromethyl-6-methoxyquinolin-4-yl)Dpropyl] -1- [2- (2, 3, 5-trifluorophenoxy)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenylthio)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoroInethyl-6-methoxyquinolin-4-yl)propyl] -1-[2-(cyclopentylthio)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl] -1-[2-(pyrid-2-yl)thioethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(thien-2-yl)thioethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(thien-2-yl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin~4-yl)propyl] -1- [2- (cyclohexyl) ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(phenyl)propyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-aininomethyl-6-methoxyquinolin-4-yDpropyl] -1- [3- (2, 3, 5-trifluorophenyl)propyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluorophenylamino)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,3,5-trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- {3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluorophenoxy)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenoxy)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-aminomethyl-5-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenylthio)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- {3-aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (cyclopentylthio) ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-{3-amninomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-{pyrid-2-yl)thioethyl]piperidine-4-carboxylic acid 4- [3- {R,S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4-yl) propyl] -1- [2- {thien-2-yl) thioethyl] piperidine-4-carboxylic acid 4- [3- {R,S) -Hydroxy-3- {3-aminomethyl-6-methoxyquinolin-4-yDpropyl] -1- [3- (2,3, 5-trifluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (thien-2-yl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- {3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(cyclohexyl)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (phenyl)propyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl) propyl]-!- [3-(2, 3, 5-trifluorophenyl) propyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (3, S-difluorophenylamino) ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5- trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (3, 5-dif luorophenoxy) ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (2, 3, 5-trifluorophenoxy)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-inorpholinomethyl-5-methoxyquinolin-4-yl)propyl] -1- [2- (2,3,5- trifluorophenylthio)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxyquinolin'-4-yl)propyl] -1- [2- (cyclopentylthio) ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-morpholinoinethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (pyrid-2-yl) thioethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxyquinolin- 4-yDpropyl] -1- [2- (thien-2-yl) thioethyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxyquinolin- 4-yl)propyl]-!- [3- (2,3, 5-trifluorophenyl)prop-2- ynyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-inorpholinomethyl-6-methoxyquinolin- 4-yl)propyl] -1- [3- (thien-2-y!)prop-2-ynyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-rnethy!-6-methoxyquinolin-4- yl)propyl] -!- [3- (2, 4, 6-trif l-uorophenyl)propyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-methyl-6-methoxyquinolin-4- yl)propyl]-1-[3-(3,4,5-trifluorophenyl)propyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-methyl-6-methoxyquinolin-4- yl)propyl]-!-[2-(2,4,6-trifluorophenylthio)ethyl]piperidine- 4-carboxylic acid 4-[3- (R,S) -Hydroxy-3- {3-inethyl-6-methoxyquinolin-4- yDpropyl] -!- [2- (3,4, 5-trif luorophenylthio) ethyl Jpiperidine- 4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-methyl-6-methoxyquinolin-4- yl)propyl]-l-[2-(2,4,6- trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-methyl-6-methoxyquinolin-4- yl)propyl]-l-[2-(3,4,5- trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-methyl-6-methoxyquinolin-4-yl)propyl]-!-[2-(2,4,6-trifluorophenoxy)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S)-Hydroxy-3- (3-methyl-6-]methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-methyl-6-methoxyquinolin-4-yl)propyl]-!-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-methyl-6-methoxyquino!in-4-yl)propyl]-!- [3- (3,4, 5-trifluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yDpropyl] -!- [3- (2, 4, 6-trif luorophenyl)propyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-!-[3-(3,4,5-trifluorophenyl)propyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-!-[2-(2,4,6-trifluorophenylthio)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenylthio)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-!-[2-(2,4,6-trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-l-[2-{3,4,5- trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenoxy)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-dimethylamino-6-methoxyquinolin-4-yDpropyl] -1- [3- (2, 4, 6-trif luorophenyl)propyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-dimethylamino-6-methoxyquinolin-4-yDpropyl] -1- [3- (3,4, 5-trif luorophenyl)propyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-diinethylamino-6-methoxYquinolin-4-yl)propyl]-l-[2-(2,4,6-trifluorophenylthio)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-dimethylamino-6-methoxyquinolin-4-yDpropyl] -1- [2- (3, 4, 5-trif luorophenylthio) ethyl ]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,4,6- trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-l-[2-(3,4,5- trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-{3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenoxy)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-dimethylamino-6-methoxyquinolin-4-yDpropyl] -1- [3- (2,4, 6-trif luorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-dimethylamino-6-methoxyquinolin-4-yDpropyl] -1- [3- (3,4, 5-trif luorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-l-[3-(3,4,5-trifluorophenyl)propyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenylthio)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenylthio)ethylJpiperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-hydroxymethyl-6-methoxyquinolin-4- yl)propyl]-l-[2-(2,4,6- trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-hydroxymethyl-6-methoxyquinolin-4- yl)propyl]-l-[2-(3,4,5- trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-{3-hydroxymethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,4,6-trifluorophenoxy)ethyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-hydroxymethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-hydroxymethyl-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,4,6-trifluorophenyl)prop-2- ynyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-hydroxymethyl-6-methoxyquinolin-4- yl)propyl]-l-[3-(3,4,5-trifluorophenyl)prop-2- ynyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-f luoromethyl-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,4,6-trifluorophenyl)propyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4- yDpropyl] -1- [3- (3,4, 5-trif luorophenyl) propyl ]piperidine-4- carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoroinethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,4,6-trifluorophenylthio)ethyl]piperidine- 4-carboxylic acid 4- [3- (R,S) -Hydroxy-3- (3-f luoromethyl-6-methoxyquinolin-4-yDpropyl] -1- [2- (3, 4, 5-trif luorophenylthio)ethyl]piperidine 4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,4,6- trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-l-[2-(3,4,5- trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy--3- (3-f luoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenoxy)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl] -1-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoroinethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yDpropyl] -1- [3- (3,4, 5-trif luorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-aininomethyl-6-methoxyquinolin-4-yDpropyl] -1- [3- (2,4, 6-trif luorophenyl) propyl ]piperidine-4-carboxylic acid 4- [3- (R,S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4-yDpropyl] -1- [3- (3,4, 5-trifluorophenyl)propyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4- yDpropyl] -1- [2- (2,4, 6-trif luorophenylthio) ethyl] piperidine- 4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,4,5-trifluorophenylthio)ethyl]piperidine- 4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4- yl)propyl]-l-[2-(2,4,6- trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4- yDpropyl]-1-[2-(3,4, 5- trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-aminomethyl-6-methoxyquinolin-4- yDpropyl] -1- [2- (2,4, 6-trif luorophenoxy) ethyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4- yl)propyl]-1- [2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Hydrox/-3-(3-aminomethyl-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,4,6-trifluorophenyl)prop-2- ynyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4- yDpropyl] -1- [3- (3,4, 5-trif luorophenyl)prop-2- ynyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-morpholinomethyl-6-methoxyquinolin- 4-yl)propyl]-l-[3-(2,4,6-trifluorophenyl)propyl]piperidine- 4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)propyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- {3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,4,6- trif luorophenylthio) ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (3 , 4, 5- trif luorophenylthio) ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6- trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5- trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenoxy)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Hydroxy-3-(3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl) propyl] -l-heptylpiperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[4-phenylbutyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- {3-chloro-6-mettioxyquinolin-4- yl) propyl] -1- [3- (phenyl)propyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4~ yl)propyl] -1- [4- (2-f luorophenyl)propyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [4- (3-f luorophenyl)propyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-!-[3-{4-fluorophenyl)propyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [4- (4-f luorophenyl)butyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [3- (2, 3-dif luorophenyl)propyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[4-(2,3-difluorophenyl)propyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-rnethoxyquinolin-4- yl)propyl]-l- [3- (2, 6-dif luorophenyl)propyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[4-(2,6-difluorophenyl)propyl]piperidine-4- carboxylic acid 4- [3- (R,S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(3,5-difluorophenyl)propyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,3,5-trifluorophenyl)propyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,4,6-trifluorophenyl)propyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [3- (3, 4, 5-trifluorophenyl)propyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-phenylthio-propyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[3-(2-fluorophenylthio)propyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [3- (3-f luorophenylthio)propyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [2- (4-fluorophenylthio) ethyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(4-fluorophenylthio)propyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl) propyl] -1- [2- (2, 3-dif luorophenylthio) ethyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [3- (2, 3-difluorophenylthio)propyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [2- (2, 6-dif luorophenylthio)ethyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,3,5-trifluorophenylthio)ethyl]piperidine- 4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,4,6-trifluorophenylthio)ethyl]piperidine- 4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,4,5-trifluorophenylthio)ethyl]piperidine- 4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,3,5-trifluorophenoxy)ethyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,4,6-trifluorophenoxy)ethyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-!-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-inethoxyquinolin-4- yl) propyl] -1- [2- (3, 5-difluorophenylamino) ethyl]piperidine-4- carboxylic acid 4- [3- (R, S)-Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[2-(2,3,5- trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[2-(2,4,6- trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[2-(3,4,5- trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,6-difluorophenylthio)propyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [2- (2-chlorophenylthio) ethyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [3- (2-chlorophenylthio)propyl]piperidine-4- carboxylic acid 4-[3-{R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(3-chlorophenylthio)ethyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Fluoro-3-{3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[3-(3-chlorophenylthio)propyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(4-chlorophenylthio)ethyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(4-chlorophenylthio)propyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(2-methylphenylthio)ethyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[3-(2-methylphenylthio)propyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [2- (3-methylphenylthio) ethyl]piperidine-4- carboxylic acid 4-[3-(R, S)-Fluoro-3-(3-chloro-6-methoxyguinolin-4- yl)propyl]-1-[3-{3-methylphenylthio)propyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-'4- yDpropyl]-1- [2- (4-methylphenylthio) ethyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[3-{4-methylphenylthio)propyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[2-(2- trifluoromethylphenylthio)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[3-(2- trifluoromethylphenylthio)propyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[2-(3- trifluoromethylphenylthio)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro~6-methoxyquinolin-4- yl)propyl]-l-[3-(3- trifluoromethylphenylthio)propyl]piperidine-4-carboxylic acid 4-[3-(R, S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[2-(4- trifluoromethylphenylthio)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[3-(4- trifluoromethylphenylthio)propyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(2-methoxyphenylthio)ethyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Fluoro-3-{3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-{2-methoxyphenylthio)propyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyguinolin-4- yl) propyl] -1- [2- (3-methoxyphenylthio) ethyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl) propyl] -1- [3- (3-methoxyphenylthio)propyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [2- (4-methoxyphenylthio) ethyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [3- (4-methoxyp]ienylthio)propyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [cyclopentylmethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(cyclopentyl)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [2- (cyclohexyl) ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-5-methoxyquinolin-4- yl)propyl] -1- [2- {eye 1 opentylthio) ethyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyguinolin-4- yl)propyl] -1- [3- (cyclopentylthio)propyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyguinolin-4-yl)propyl]-1-[3-(cyclohexylthio)propyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yDpropyl] -1- [2- (pyrid-2-yl) thioethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[4-(thien-2-yl)butyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) propyl] -1- [3- {thien-2-yl) thiopropyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- {3-chloro-6-methoxyquinolin-4-yl)propyl]-l-[3-(thien-3-yl)propyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[4-(thien-3-yl)butyl]piperidine-4-carboxylic acid 4- [3- (R,S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yDpropyl] -1- [2- (thien-2-yl) thioethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yDpropyl] -1- [2- {thien-3-yl) thioetllyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-l-[3-(thien-3-yl)thiopropyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4--yl)propyl] -1- [3- (1, 3-thiazol-2-yl)propyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyguinolin-4-yl)propyl]-1-[4-(1,3-thiazol-2-yl)butyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4~ yDpropyl] -1- [3- (1, 3-thiazol-2-yl) thioethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(pyrid-2-yl)propyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [4- {pyrid-2-yl)butyl]piperidine-4-carboxylic acid 4- [3- (R,S)-Fluoro-3- (3-chloro-6-methoxyquinolin-4-yDpropyl] -1- [3- (pyrid-2-yl) t]liopropyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yDpropyl]-1- [3- (pyrid-3-yl)propyl]piperidine-4-carboxylic acid 4- [3- (R,S)-Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [4- (pyrid-3-yl)butyl]piperidine-4-carboxylic acid 4- [3- {R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [2- (pyrid-3-yl) thioethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-1- [3- (pyrid-3-yl) thiopropyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(pyrid-4-yl)propyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[4-(pyrid-4-yl)butyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(pyrid-4-yl)thioethyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Fluoro-3-{3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(pyrid-4-yl)thiopropyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(pyrazin-2-yl)propyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [4- (pyrazin-2-yl)butyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [2- (pyrazin-2-yl) thioethyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [3- (pyrazin-2-yl) thiopropyl]piperidine-4- carboxylic acid 4-[3-{R,S)-Fluoro-3-{3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (4-f luorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4-difluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4-difluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yDpropyl] -1- [3- (2,3, 5-trifluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3~{R,S)-Fluoro-3-{3-chloro-6-methoxyquinolin-4-yl)propyl]-!- [3- (2,4, 6-trif luoropl-enyl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl)propyl]-l-[3- (3,4, 5-trif luoropllenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) propyl] -1- [3- (4-chloro-3-fluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- (R,S)-Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3-chloro-4-fluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) propyl] -1- [3- (2-chloro-4-f luorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-{3-chloro-6-methoxyquinolin-4- yl)propyl]-!-[3-{3-chloro-5-fluorophenyl)prop-2- ynyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-!- [3- (4-c]:i!oro-2-fluorophenyl)prop-2- ynyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [3- (3-fluoro-4-methylpheny!)prop-2- ynyl]piperidine-4-carboxylic acid 4- [3- (R,S)-Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [3- (3, 5-bis (trif luoromethyl)phenyl)prop-2- ynyl]piperidine-4-carboxylic acid 4- [3- (R,S)-Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [3- (thien-2-yl)prop-2-ynyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [3- (thien-3-yl)prop-2-yny!]piperidine-4- carboxylic acid 4- [3- (R,S)-Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-{!,3-thiazol-2-yl)prop-2-ynyl]piperidine-4- carboxylic acid 4- [3- (R, S)-Fluoro-3- (3-chiloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(1,3-tliiazol-4-yl)prop-2-ynyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(1,3-thiazol-5-yl)prop-2-ynyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(pyrid-2-yl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(pyrid-3-yl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(pyrid-4-yl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4-yl) propyl] -1- [2- (cyclohexyl)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-methyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(phenyl)propyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)propyl]piperidine-4-carboxylic acid 4- [3- (R,S) -Fluoro-3- (3-methyll-6-methoxyquinolin-4-yl)propyl] -1- [2- (3, 5-dif luorophenylamino) etllyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-methyl-6-methoxyquinolin-4-yl)propyl]-l-[2-{2,3,5- trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-inethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (3, 5-dif luorophenoxy) ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenoxy)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenylthio)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-methyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (eye 1 opentylthio) ethyl]piperidine-4-carboxylic acid 4- [3- (R,S) -Fluoro-3- (3-methyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (pyrid-2-yl) thioetllyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-methyl-6-xnethoxyquinolin-4-yl)propyl] -1- [2- {thien-2-yl) thioethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-]:nethyl-6-methoxyquinolin-4-yl)propyl]-l- [3- (2,3, 5-trif luoropllenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- (R,S) -Fluoro-3- (3-methyl-6-methoxyquinolin-4-yl)propyl]-!- [3- (thien-2-yl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-f luoro-6-methoxyquinolin-4-yl)propyl] -1- [2- (cyclohexyl) ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-f luoro-6-methoxyquinolin-4-yl)propyl] -1- [3- (phenyl)propyl]piperidine-4-carboxylic acid 4- [ 3- (R, S) -Fluoro-3- (3-f luoro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)propyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-l-[2-(3,5-difluorophenylamino)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,3,5- trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl] -1-[2-(3,5-difluorophenoxy)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl] -1- [2-(2,3,5-trifluorophenoxy)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-!-[2-(2,3,5-trifluorophenylthio)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl] -1- [2-(cyclopentylthio)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-f luoro-6-methoxyqainolin-4-yDpropyl] -1- [2- (pyrid-2-yl) thioethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yDpropyl] -1- [2- (thien-2-yl) thioethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-{3-fluoro-6-methoxyquinolin-4-yl)propyl] -1- [3- (2,3, 5-trif luorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-l-[3-(thien-2-yl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [3- (phenyl)propyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-l-[3-(2,3,5-trifluorophenyl)propyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-dimethylainino-6-methoxyquinolin-4-yl)propyl]-l-[2-(3,S-difluorophenylamino)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-dimethylamino-6-methoxyqainolin-4-yl)propyl]-l-[2-(2,3,5- trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-dimethylamino-6-Tnethoxyquinolin-4-yl)propyl]-l-[2-(3,5-difluorophenoxy)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-!-[2-(2,3,5-trifluorophenoxy)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S)-Fluoro-3- {3-dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [2- (2, 3, 5-trifluorophenylthio) ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-dimethylamino-6-methoxyquinolin-4-yDpropyl] -1- [2- (cyclopentylthio) ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[2-(pyrid-2-yl)thioethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-{3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[2-(thien-2-yl)thioethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- {3-dimethylamino-6-methoxyquinolin-4-yDpropyl] -1- [3- (2,3, 5-trif luorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-dimethylainino-6-methoxyquinolin-4-yl)propyl]-1-[3-(thien-2-yl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-Hydroxymethyl-6-methoxyquinolin-4-yDpropyl] -1- [2- (cyclohexyl) ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (phenyl)propyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)propyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-l-[2-(3,5-difluorophenylamino)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,3,5- trif luorophenylaiTiino) ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluorophenoxy)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenoxy)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-!-[2-(2,3,5-trifluorophenylthio)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (cyclopentylthio) ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-Hydroxymethyl-6-methoxyquinolin-4-yDpropyl] -1- [2- {pyrid-2-yl) thioethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-l-[2-(thien-2-yl)thioethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-l-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- (R,S)-Fluoro -3- (3-hydroxymethyl-6-methoxyquinolin-4- yl)propyl]-1-[3-(thien-2-yl)prop-2-ynyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(cyclohexyl)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-f luoromethyl-6-methoxyquinolin-4- yl)propyl] -1- [3- (phenyl)propyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-f luoromethyl-6-methoxyquinolin-4- yl)propyl]-l-[3-(2,3,5-trifluoroplaenyl)propyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4- yl)propyl] -1- [2- (3, 5-difluorophenylamino) ethyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-f luoromethyll-6-methoxyquinolin-4- yl)propyl]-l-[2-(2,3,5- trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,5-difluorophenoxy)ethyl]piperidine-4- carlDoxylic acid 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,3,5-trifluorophenoxy)ethyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,3,5-trifluorophenylthio)ethyl]piperidine- 4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-f luoromethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (cyclopentylthio) ethyl]piperidine-4-carboxylic acid 4- [3- (R,S)-Fluoro-3- (3-f luoromethyl-6-methoxyquinolin-4-yl)propyl]-l- [2- (pyrid-2-yl) thioetllyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-fluoromethyll-6-methoxyquinolin-4-yDpropyl] -1- [2- (tlaien-2-yl) thioetllyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-f luoromet]lyl-6-methoxyquinolin-4-yl)propyl] -1-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-f luoromethyl-6-methoxyquinolin-4-yDpropyl] -1- [3- (thien-2-yl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (cycloliexyl)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-l-[3-(phenyl)propyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (2, 3, 5-trif luorophenyl)propyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-l-[2-(3,5-difluorophenylamino)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-aminormthyl-6-methoxyquinolin-4- yl)propyl]-l-[2-(2,3,5- trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-aminomethyl-6-methoxyquinolin-4- yDpropyl] -1- [2- (3, 5-dif luorophenoxy) ethyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-aminomethyl-6-methoxyguinolin-4- yDpropyl] -1- [2- (2,3, 5-trif luorophenoxy) ethyl]piperidine-4- carboxylic acid 4- [3- (R,S) -Fluoro-3- (3-aminomethyl-6-methoxyquinolin-4- yDpropyl]-1- [2- (2,3, 5-trifluorophenylthio)ethyl]piperidine- 4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-aminomethyl-6-methoxyquinolin-4- yl)propyl] -1- [2- (cyclopentylthio) ethyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-aminomethyl-6-methoxyquinolin-4- yl)propyl] -1-[2-(pyrid-2-yl) thioethyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-aminomethyl-6-methoxyquinolin-4- yDpropyl] -1- [2- (thien-2-yl) thioethyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-aminomethyl-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,3,5-trifluorophenyl)prop-2- ynyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-aminomethyl-6-methoxyquinolin-4- yl)propyl] -1- [3- (thien-2-yl)prop-2-ynyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-morpholinomethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(cyclohexyl)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-morpholinomethyl-6-methoxyquinolin-4- yl)propyl] -1- [3- (phenyl)propyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-morpholinomethyl-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,3,5-trifluorophenyl)propyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-morpholinomethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,5-difluorophenylamino)ethyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-morpholinomethyl-6-methoxyquinolin-4- yl)propyl]-l-[2-(2,3,5- trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-morpholinomethyl-6-methoxyquinolin-4- yl)propyl]-l-[2-(3,5-difluorophenoxy)ethyl]piperidine-4- carboxylic acid 4- [3- (R, S)-Fluoro-3-(3-morpholinomethyl-6-methoxyquinolin-4- yl)propyl]-!-[2-(2,3,5-trifluorophenoxy)ethyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-morpholinomethyl-6-methoxyc|uinolin-4- yl)propyl]-1-[2-(2,3,5-trifluorophenylthio)ethyl]piperidine- 4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-inorpholinomethyl-6-methoxyquinolin-4- yl)propyl] -1- [2- (cyclopentylthio) ethyl]piperidine-4- carboxylic acid 4- [3- (R,S) -Fluoro-3- (3-morpholinomethyl-6-methoxyquinolin-4- yDpropyl] -1- [2- (pyrid-2-yl) thioethyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Fluoro-3- {3-morpholinomethyl-6-methoxyquinolin-4- yl)propyl] -1- [2- (thien-2-yl) thioethyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-morpholinomethyl-6-methoxyquinolin-4- yDpropyl] -1- [3- (2,3, 5-trif luorophenyl)prop-2- ynyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-morpholinomethyl-6-methoxyquinolin-4- yDpropyl] -1- [3- (thien-2-yl)prop-2-ynyl]piperidine-4- carboxylic acid 4- [3- (R,S)-Fluoro-3- (3-methyl-6-methoxyquinolin-4- yl)propyl]-!- [3- (2, 4, 6-trifluorophenyl)propyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-methyl-6-methoxyquinolin-4- yl)propyl]-1-[3-(3,4,5-trifluorophenyl)propyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-methyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,4,6-trifluoroptienylthio)ethyl]piperidine- 4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-inethyl-6-methoxyqainolin-4- yl)propyl]-1-[2-(3,4,5-trifluorophenylthio)ethyl]piperidine- 4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4- yl)propyl]-l-[2-(2,4,6- trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4- yl)propyl]-l-[2-{3,4,5- trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-methyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,4,6-trifluorophenoxy)ethyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4- carboxylic acid 4-[3-{R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4- yDpropyl] -1- [3- (2,4, 6-trif luorophenyl)prop-2- ynyl]piperidine-4-carl30xylic acid 4- [3- (R, S) -Fluoro-3- (3-methyl-6-methoxyquinolin-4- yl)propyl]-1-[3-(3,4,5-trifluorophenyl)prop-2- ynyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,4,6-trifluorophenyl)propyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4- yDpropyl] -1- [3- (3,4, 5-trif luorophenyl)propyl] piper idine-4- carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4- yl)propyl]-!-[2-(2,4,6-trifluorophenylthio)ethyl]piperidine- 4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4- yl)propyl]-!-[2-(3,4,5-trifluorophenylthio)ethyl]piperidine- 4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,4,6- trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-l-[2-(3,4,5- trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yDpropyl] -1- [2- (2,4, 6-trifluorophenoxy)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-!-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-!-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-!-[3-(2,4,6-trifluorophenyl)propyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-dimethylamino-6-methoxyquinolin-4-yDpropyl] -1- [3- (3,4, 5-trifluorophenyl)propyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-!-[2-(2,4,6-trifluorophenylthio)ethyl]piperidine-4-carboxylic acid 4- [3- (R,S) -Fluoro-3- (3-dimethylamino-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,4,5-trifluorophenylthio)ethyl]piperidine- 4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-dimethylamino-6-methoxyquinolin-4- yl)propyl]-l-[2-(2,4,6- trifluorophenylainino)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- {3-dimethylamino-6-methoxyquinolin-4- yl)propyl]-l-[2-(3,4,5- trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-dimethylamino-6-methoxyquinolin-4- yDpropyl] -1- [2- (2,4, 6-trif luorophenoxy) ethyl ]piperidine-4- carboxylic acid 4- [3- (R,S) -Fluoro-3- (3-dimethylamno-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4- carboxylic acid 4- [3- (R,S) -Fluoro-3- (3-dimethylainino-6-methoxyquinolin-4- yDpropyl] -1- [3- (2,4, 6-trif luorophenyl)prop-2- ynyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-dimethylamino-6-methoxyquinolin-4- yDpropyl] -1- [3- (3,4, 5-trif luorophenyl)prop-2- ynyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,4,6-trifluorophenyl)propyl]piperidine-4- carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-hydroxymethyl-6-methoxyquinolin-4- yl)propyl] [sic] acid 4- [3- (R, S) -Fluoro-3- (3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,4, 6-trifluorophenylthio)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl) propyl] -1- [2- (3,4, 5-trif luorcphenylthio) ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-]iydroxymethyl-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,4,6- trifluorophenylamino) ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-l-[2-(3,4,5- trif luorophenylamino) ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-!-[2-(2,4,6-trifluorophenoxy)et]ayl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-hydroxymethyl-6-methoxyquinolin-4-yDpropyl] -1- [2- (3,4, 5-trif luorophenoxy)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-hydroxymethyl-6-methoxyquinolin-4-yDpropyl] -1- [3- (2,4, 6-trif luorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-hydroxymethyl-6-methoxyquinolin-4-yDpropyl] -1- [3- (3, 4, 5-trif luorop]aenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-!-[3-(2,4,6-trifluorop]lenyl)propyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4-yDpropyl] -1- [3- (3, 4, 5-trif luorophenyl)propyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4-yDpropyl] -1- [2- (2,4, 6-trif luorophenylthio)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-l-[2-(3,4,5-trifluorophenylthio)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (2, 4, 6- trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-l-[2-(3,4,5- trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenoxy)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-fluoromethyl-6-methoxyc[uinolin-4-yl)propyl]-1- [3-(2,4,6-trifluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4-yDpropyl] -1- [3- (3,4, 5-trif luorophenyl) prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)propyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-aminomethyl-6-methoxyquinolin-4-yDpropyl] -1- [3- (3,4, 5-trifluorophenyl)propyl]piperidine-4-carboxylic acid 4- [3- (R, S)-Fluoro-3- (3-aininomethyl-6-methoxyquinolin-4-yl)propyl]-!- [2- (2, 4, 6-trif luoroplienylthio)etlayl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-aminomethyl-6-methoxyquinolin-4-yDpropyl] -1- [2- (3, 4, 5-trif luorophenylthio) ethyl]piperidine-4-carboxylic acid 4- [3- (R,S) -Fluoro-3- (3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,4,6- trifluorophenylamino) ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-aminomethyl-6-inethoxyquinolin-4-yl)propyl]-l-[2-(3,4,5- trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenoxy)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-aminomethyl-6-inethoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-axninomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-aminomethyl-6-methoxyquinolin-4- yl)propyl] -1- [3- (3,4, 5-trif luorophenyl)prop-2- ynyl]piperidine-4-carboxylic acid 4- [3- (R,S)-Fluoro-3- (3-morpholinomethyl-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,4,6-trifluorophenyl)propyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-morpholinomethyl-6-methoxyquinolin-4- yl)propyl]-1-[3-(3,4,5-trifluorophenyl)propyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-morpholinomethyl-6-methoxyquinolin-4- yl)propyl] -1- [2- (2, 4, 6-trifluorophenylthio)ethyl]piperidine- 4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-morpholinomethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,4,5-trifluorophenylthio)ethyl]piperidine- 4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-inorpholinomethyl-6-methoxyquinolin-4- yl)propyl]-l-[2-(2,4,6- trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-inorpholinomethyl-6-methoxyquinolin-4- yl)propyl]-l-[2-(3,4,5- trifluorophenylamino)ethyl]piperidine-4-carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-morpholinomethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,4,6-trifluorophenoxy)ethyl]piperidine-4- carboxylic acid 4- [3-(R,S)-Fluoro-3-(3-inorpholinomethyl-6-methoxyquinolin-4- yl)propyl]-!-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4- carboxylic acid 4- [3- (R, S) -Fluoro-3- (3-morpholinomethyl-6-methoxyquinolin-4-yDpropyl] -1- [3- {2,4, 6-trifluorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(R,S)-Fluoro-3-(3-morpholinomethyl-6-methoxyquinolin-4-yDpropyl] -1- [3- (3,4, 5-trif luorophenyl)prop-2-ynyl]piperidine-4-carboxylic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-heptylpiperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[4-phenylbutyl]piperidine-4-acetic acid 4-[3-{3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(phenyl)propyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[4-(2-fluorophenyl)propyl]piperidine-4-acetic acid 4-[3-{3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[4-(3-fluorophenyl) propyl]piperidine-4-acetic acid 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(4-fluorophenyl) propyl] piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[4-(4-fluorophenyl)butyl]piperidine-4-acetic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (2,3-dif luorophenyl) propyl ] piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-l-[4-{2,3-dif luorop]rienyl)propyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,6-difluorophenyl)propyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[4-(2,6-difluorophenyl)propyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-l-[3-(3,5-difluorophenyl)propyl]piperidine-4-acetic acid 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluoroplaenyl)propyl]piperidine-4-acetic acid 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-l-[3-(2,4,6-trifluorophenyl)propyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)propyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-phenylthiopropyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2-fluorophenylthio)propyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3-fluorophenylthio)propyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(4-fluorophenylthio)ethyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(4-fluorophenylthio)propyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3-difluorophenylthio)-ethyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3-difluorophenylthio)-propyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,6-difluorophenylthio)-ethyl]piperidine-4-acetic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,3,5- trif luorophenylthio) -ethyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6- trifluorophenylthio)-ethyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5- trif luorophenylttiio) -ethyl jpiperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1- [2- (3,5- difluorophenoxy)ethyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,3,5- trifluorophenoxy)-ethyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-!-[2-(2,4,6- trifluorophenoxy)-ethyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5- trifluorophenoxy)-ethyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-!-[2-(3,5- difluorophenylamino)-ethyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-!-[2-(2,3,5- trifluorophenylamino)-ethyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-!-[2-(2,4,6- trifluorophenylamino)-ethyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5- trifluorophenylamino)-ethyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,6- difluorophenylthio)-propyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-!-[2-(2- chlorophenylthio)ethyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2-chlorophenylthio)propyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-xnethoxyquinolin-4-yl)propyl]-1-[2-(3-chlorophenylthio)ethyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3-chlorophenylthio)propyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1- [2- (4-chlorophenyltlaio) ethyl]piperidine-4-acetic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (4-chlorophenylthio)propyl]piperidine-4-acetic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [2- (2-mettiylphenyltliio) ethyl]piperidine-4-acetic acid 4- [3- {3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (2-methylphenylthio) -propyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1- [2- (3-methlphenylthio) ethyl]piperidine-4-acetic acid 4- [3- (3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (3-methylphenylthio)-propyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(4-methylphenylthio)ethyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(4-methyllphenylthio)-propyl]piperidine-4-acetic acid 4-[3-{3-Chloro-6-methoxyquinolin-4-yl)propyl]-l-[2-(2-trif luoromethylphenylthio) -ethyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2-trifluoromethylphenylthio)-propyl]piperidine-4-acetic acid 4- [3- (3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- [2- (3- trifluoromethylphenylthio)-ethyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3- trifluoromethylphenylthio)-propyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(4- trifluoromethylphenylthio)-ethyl]piperidine-4-acetic acid 4-[3-{3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(4- trifluoromethylphenylthio)-propyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyc[uinolin-4-yl)propyl]-1-[2-(2- methoxyphenylthio)-ethyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2- methoxyphenylthio)-propyl]piperidine-4-acetic acid 4-[3-{3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3- methoxyphenylthio)-ethyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3- methoxyphenylthio)-propyl]piperidine-4-acetic acid 4- [3- (3-Chloro-6-methoxyquinolin-4-yl)propyl]-l- [2- (4- methoxyphenylthio)-ethyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(4- methoxyphenylthio)-propyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1- [cyclopentylmethyl]piperidine-4-acetic acid 4-[3-{3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2- (cyclopentyl)ethyl]piperidine~4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2- (cyclohexyl)ethyl]piperidine-4-acetic acid 4- [3- {3-Ctiloro-6-methoxyquinolin-4-yl)propyl] -1- [2- (cyclopentylthio) ethyl]piperidine-4-acetic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl]-1- [3- (cyclopentylthio)propyl]piperidine-4-acetic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (cyclohexylthio) propyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-met]aoxyquinolin-4-yl)propyl]-1-[2-{pyrid-2- yl) thioethyl]piperidine-4-acetic acid 4- [3- {3-chloro-6-methoxyquinolin-4-yl)propyl]-!- [4- (thien-2- yl)butyl]piperidine-4-acetic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- {thien-2- yl)thiopropyl]piperidine-4-acetic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (thien-3- yl)propyl]piperidine-4-acetic acid 4- [3- (3-chloro-5-methoxyquinolin-4-yl)propyl] -1- [4- (thien-3- yl)butyl]piperidine-4-acetic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [2- (thien-3- yl)thioethyl]piperidine-4-acetic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (thien-3- yl)thiopropyl]piperidine-4-acetic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -l-[3-(l,3- thiazol-2-yl)propyl]piperidine-4-acetic acid 4- [3-{3-chloro-6-methoxyquinolin-4-yl)propyl]-l-[4- (1,3- thiazol-2-yl) butyl]piperidine-4-acetic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (1,3- thiazol-2-yl) thioethyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(pyrid-2- yl)propyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[4-{pyrid-2- yl)butyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(pyrid-2- yl)thiopropyl]piperidine-4-acetic acid 4-[3-{3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(pyrid-3- yl)propyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[4-(pyrid-3- yl)butyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(pyrid-3- yl)thioethyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(pyrid-3- yl) thiopropyl]piperidine-4-acetic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (pyrid-4- yl)propyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[4-(pyrid-4- yl)butyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(pyrid-4- yl) thieothyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(pyrid-4- yl) thiopropyl]piperidine-4-acetic acid 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(pyrazin- 2-yl)propyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[4-(pyrazin- 2-yl)butyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(pyrazin-2-yl)thioethyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(pyrazin-2-yl)thiopropyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(4-fluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1- [3-(3,4-difluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-l- [3- (2,4-dif luorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (4-chloro-3-fluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-!-[3-(3-chloro-4-fluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2-chloro-4-fluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (3-chloro-5-fluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (4-chloro-2-fluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3- fluoro-4-methylphenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,5- bis(trifluoroinethyl)phenyl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (thien-2- yl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (3-Chloro-6-methoxyguinolin-4-yl)propyl] -1- [3- (thien-3- yl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(1,3- thiazol-2-yl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-{1,3- thiazol-4-yl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-l-[3-(1,3- thiazol-5-yl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (pyrid-2- yl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(pyrid-3- yl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (pyrid-4- yl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (3-methyll-6-methoxyquinolin-4-yl)propyl] -1- [2- (cyclohexyl) ethyl]piperidine-4-acetic acid 4- [3- (3-Methyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (phenyl) propyl] piperidine-4-acetic acid 4- [3- (3-Methyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (2, 3 , 5- trifluorophenyl)-propyl]piperidine-4-acetic acid 4- [3- (3-Methyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (3, 5-difluorophenyl-amino)ethyl]piperidine-4-acetic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenyl-amino)ethyl]piperidine-4-acetic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluorophenoxy)ethyl]piperidine-4-acetic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenoxy)-ethyl]piperidine-4-acetic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenylthio)-ethyl]piperidine-4-acetic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(cyclopentylthio)ethyl]piperidine-4-acetic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(pyrid-2-yl)thioethyl]piperidine-4-acetic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(thien-2-yl)thioethyl]piperidine-4-acetic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(thien-2-yl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(cyclohexyl)ethyl]piperidine-4-acetic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[3-(phenyl)propyl]piperidine-4-acetic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)-propyl]piperidine-4-acetic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluorophenylamino)-ethyl]piperidine-4-acetic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenylamino)-ethyl]piperidine-4-acetic acid 4-[3-{3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluorophenoxy)ethyl]piperidine-4-acetic acid 4-[3-{3-Fluoro-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,3,5-trifluorophenoxy)ethyl]-piperidine-4-acetic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenylthio)-ethyl]piperidine-4-acetic acid 4-[3-(3-Fluoro-6-xnethoxyquinolin-4-yl)propyl]-1-[2-(cyclopentylthio)ethyl]piperidine-4-acetic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(pyrid-2-yl)thioethyl]piperidine-4-acetic acid 4-[3-{3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(thien-2-yl)thioethyl]piperidine-4-acetic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[3-(thien-2-yl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(3-Dimethylainino-6-methoxyquinolin-4-yl)propyl]-1-[2-(cyclohexyl)ethyl]piperidine-4-acetic acid 4- [3- (3-Dixnethylainino-6-methoxyquinolin-4-yl)propyl] -1- [3-(phenyl)propyl]piperidine-4-acetic acid 4-[3-(3-Dimethylainino-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)-propyl]piperidine-4-acetic acid 4- [3- (3-Dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [2- (3,5-difluorophenylamino)-ethyl]piperidine-4-acetic acid 4- [3- (3-Dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,3,5-trifluorophenyl-amino)ethyl]piperidine-4-acetic acid 4-[3-(3-Dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[2- (3,5-difluorophenoxy)-ethyl]piperidine-4-acetic acid 4-[3-(3-Diinethylamino-6-methoxyquinolin-4-yl)propyl]-1-[2- (2,3,5-trifluorophenoxy)-ethyl]piperidine-4-acetic acid 4- [3- (3-Dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,3,5-trifluorophenylthio)-ethyl]piperidine-4-acetic acid 4- [3- (3-Dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [2- (cyclopentylthio)-ethyl]piperidine-4-acetic acid 4-[3-(3-Dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[2- (pyrid-2-yl)thio-ethyl]piperidine-4-acetic acid 4-[3-(3-Dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[2- (thien-2-yl)thio-ethyl]piperidine-4-acetic acid 4- [3- (3-Dixnethylainino-6-methoxyquinolin-4-yl)propyl] -1- [3- (2,3,5-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(3-Dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[3- (thien-2-yl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (cyclohexyl) ethyl]piperidine-4-acetic acid 4- [3- (3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (phenyl)propyl]piperidine-4-acetic acid 4- [3- (3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (2,3,5-trifluorophenyl)-propyl]piperidine-4-acetic acid 4-[3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1 [2: (3, 5-difluorophenyl-amino)ethyl]piperidine-4-acetic acid 4- [3- (3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl] - I (2 (2,3,5-trifluorophenyl-amino)ethyl]piperidine-4-acetic acid 4- [3- (3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl] -1 ['2 (3,5-difluorophenoxy)-ethyl]piperidine-4-acetic acid 4- [3- (3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl] -1 (2' (2,3,5-trifluorophenoxy)-ethyl]piperidine-4-acetic acid 4-[3-{3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]- [2 (2,3,5-trifluorophenylthio)-ethyl]piperidine-4-acetic acid 4-[3- (3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl] -1 [2 (cyclopentylthio)-ethyl]piperidine-4-acetic acid 4-[3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl] 1 [2- (pyrid-2-yl)thioethyl]-piperidine-4-acetic acid 4-[3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl] 1 [2 (thien-2-yl)thioethyl]-piperidine-4-acetic acid 4-[3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl] 1 (3 (2,3, 5-trif luorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl] 1 [3 (thien-2-yl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(3~Fluoroinethyl-6-methoxyquinolin-4-yl)propyl] 1 [2 (cyclohexyl)ethyl]piperidine-4-acetic acid 4-[3-(3-Fluoroinethyl-6-methoxyquinolin-4-yl)propyl] -1- [ 3 (phenyl)propyl]piperidine-4-acetic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl] 1 (3- (2,3, 5-trif luorophenyl) -propyl]piperidine-4-acetic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2- (3,5-difluorophenylamino)-ethyl]piperidine-4-acetic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2- (2,3,5-trifluorophenylamino)-ethyl]piperidine-4-acetic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2- (3,5-difluorophenoxy)-ethyl]piperidine-4-acetic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2- (2,3,5-trifluorophenoxy)-ethyl]piperidine-4-acetic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2- (2,3,5-trifluorophenylthio)-ethyl]piperidine-4-acetic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2- (cyclopentylthio)-ethyl]piperidine-4-acetic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2- (pyrid-2-yl)thioethyl]piperidine-4-acetic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2- (thien-2-yl)thioethyl]piperidine-4-acetic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[3- (2,3,5-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[3- (thien-2-yl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2- (cyclohexyl)ethyl]piperidine-4-acetic acid 4-[3-(3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3- (pheny1)propyl]piperidine-4-acetic acid 4-[3-(3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3- (2,3,5-trifluorophenyl)-propyl]piperidine-4-acetic acid 4- [3- (3-Arninomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- {3, 5-dif luorophenylamino) -ethyl]piperidine-4-acetic acid 4-[3-{3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2- (2,3,5-trifluorophenylamino)-ethyl]piperidine-4-acetic acid 4-[3-(3-Aminoinethyl-6-methoxyquinolin-4-yl)propyl]-1-[2- (3,5-difluorophenoxy)-ethyl]piperidine-4-acetic acid 4- [3- (3-Aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,3,5-trifluorophenoxy)-ethyl]piperidine-4-acetic acid 4- [3- (3-AndnoTnethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,3,5-trifluorophenylthio)-ethyl]piperidine-4-acetic acid 4- [3- (3-aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (cyclopentylthio)-ethyl]piperidine-4-acetic acid 4-[3-(3-Aminoxnethyl-6-methoxyquinolin-4-yl)propyl]-1-[2- {pyrid-2-yl)thioethyl]piperidine-4-acetic acid 4-[3-(3-Aininomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2- {thien-2-yl)thioethyl]piperidine-4-acetic acid 4-[3-(3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3- {2,3,5-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3- (thien-2-yl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1- [2-(cyclohexyl)-ethyl]piperidine-4-acetic acid 4-[3-(3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1- [3-(phenyl)propyl]piperidine-4-acetic acid 4- [3- (3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [3-(2,3,5-trifluorophenyl)-propyl]piperidine-4-acetic acid 4- [3- (3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2-(3,5-difluorophenyl-amino)ethyl]piperidine-4-acetic acid 4-[3-(3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1- [2- (2,3, 5-trifluorophenyl-amino) ethyl] piperidine-4-acetic acid 4- [3- (3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (3, 5-dif luorophenoxy) -ethyl]piperidine-4-acetic acid 4- [3- (3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2-(2,3,5-trifluorophenoxy)-ethyl]piperidine-4-acetic acid 4- [3- (3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,3, 5-trifluorophenyl-thio) ethyl] piperidine-4-acetic acid 4- [3- (3-M02rpholinoinethyl-6-methoxyquinolin-4-yl)propyl] -1- [2-(cyclopentyl-thio)ethyl]piperidine-4-acetic acid 4-[3-(3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1- [2-(pyrid-2-yl)thioethyl]-piperidine-4-acetic acid 4-[3-(3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1- [2-(thien-2-yl)thioethyl]-piperidine-4-acetic acid 4-[3-(3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1- [3-(2,3,5-trifluorophenyl)-prop-2-ynyl]piperidine-4-acetic acid 4- [3- (3-Morpholinoinethyl-6-methoxyquinolin-4-yl)propyl] -1- [3-(thien-2-yl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5- trifluorophenyl)-propyl]piperidine-4-acetic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6- trifluorophenylthio)-ethyl]piperidine-4-acetic acid 4-[3-(3-Methyl-5-methoxyquinolin-4-yl)propyl]-l-[2-(3,4, 5- trifluorophenylthio)-ethyl]piperidine-4-acetic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6- trifluorophenylamino)-ethyl]piperidine-4-acetic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-l-[2-(3,4,5- trifluorophenylamino)-ethyl]piperidine-4-acetic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,4,6- trifluorophenoxy)ethyl]-piperidine-4-acetic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5- trifluorophenoxy)ethyl]-piperidine-4-acetic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6- trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5- trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-!-[3-(2,4,6- trifluorophenyl)propyl]-piperidine-4-acetic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5- trifluorophenyl)propyl]-piperidine-4-acetic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1- [2- (2,4,6- trifluorophenylthio)ethyl]-piperidine-4-acetic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5- trifluorophenylthio)ethyl]-piperidine-4-acetic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,4,6- trifluorophenylamino)-ethyl]piperidine-4-acetic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5- trifluorophenylamino)-ethyl]piperidine-4-acetic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenoxy)ethyl]-piperidine-4-acetic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trif luorophenoxy) ethyl] -piperidine-4-acetic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1- [3- (2,4,6-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-l-[3-(3,4,5-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (3-Dimethyllamino-6-methoxyquinolin-4-yl)propyl] -1- [3-(2,4,6-trifluorophenyl)-propyl]piperidine-4-acetic acid 4- [3- (3-Dimethyllamino-6-methoxyquinolin-4-yl)propyl] -1- [3-(3,4,5-trifluorophenyl)-propyl]piperidine-4-acetic acid 4- [3- (3-Dimethyllamino-6-methoxyquinolin-4-yl)propyl] -1- [2-(2,4, 6-trifluorophenylthio) -ethyl]piperidine-4-acetic acid 4- [3- (3-Dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [2-(3,4, 5-trifluorophenylthio)-ethyl]piperidine-4-acetic acid 4- [3- (3-Dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [2-(2,4, 6-trifluorophenyl-amino)ethyl]piperidine-4-acetic acid 4- [3- (3-Dimethylainino-6-methoxyquinolin-4-yl)propyl] -1- [2-(3,4, 5-trif luorophenyl-amino)ethyl]piperidine-4-acetic acid 4- [3- (3-Dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [2-(2,4, 6-trifluorophenoxy)-ethyl]piperidine-4-acetic acid 4- [3- (3-Dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [2-(3,4, 5-trif luorophenoxy) -ethyl]piperidine-4-acetic acid 4- [3- (3-Dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [3-(2,4,6-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (3-Dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [3-(3,4,5-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (3-Hydroxymethyl-6-inethoxyquinolin-4-yl)propyl] -1- [3-(3,4, 5-trifluorophenyl)-propyl]piperidine-4-acetic acid 4- [3- (3-HydroxyTnethyl-6-methoxyquinolin-4-yl)propyl] -1- [2-(2,4,6-trifluorophenylthio)-ethyl]piperidine-4-acetic acid 4-[3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenylthio)-ethyl]piperidine-4-acetic acid 4- [3- (3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl] -1- [2-(2,4,6-trifluorophenylamino)-ethyl]piperidine-4-acetic acid 4-[3-(3-HydroxyTnethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenylamino)-ethyl]piperidine-4-acetic acid 4-[3-(3-Hydroxyinethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenoxy)-ethyl]piperidine-4-acetic acid 4- [3- (3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl] -1- [2-(3,4,5-trifluorophenoxy)-ethyl]piperidine-4-acetic acid 4-[3-(3-Hydroxyinethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (3-Hydroxymethyl-6-inethoxyquinolin-4-yl)propyl] -1- [3-(3,4,5-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(3-Fluoromethy1-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)-propyl]piperidine-4-acetic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)-propyl]piperidine-4-acetic acid 4- [3- (3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl] -1- [2-(2,4,6-trifluorophenylthio)-ethyl]piperidine-4-acetic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenylthio)-ethyl]piperidine-4-acetic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenylamino)-ethyl]piperidine-4-acetic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenylamino)-ethyl]piperidine-4-acetic acid 4- [3- (3-Fluoromethyl-6-inethoxyquinolin-4-yl)propyl] -1- [2-(2,4,6-trifluorophenoxy)-ethyl]piperidine-4-acetic acid 4-[3-(3-Fluoromethyl-6-xnethoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenoxy)ethyl]-piperidine-4-acetic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (3-Aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [3-(2,4,6-trifluorophenyl)-propyl]piperidine-4-acetic acid 4-[3-(3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)-propyl]piperidine-4-acetic acid 4-[3-(3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenylthio)-ethyl]piperidine-4-acetic acid 4-[3-(3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenylthio)-ethyl]piperidine-4-acetic acid 4-[3-(3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenylamino)-ethyl]piperidine-4-acetic acid 4-[3-(3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenylamino)-ethyl]piperidine-4-acetic acid 4- [3- (3-Aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2-(2,4,6-trifluorophenoxy)-ethyl]piperidine-4-acetic acid 4-[3-(3-Aininomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenoxy)-ethyl]piperidine-4-acetic acid 4- [3- (3-Aininomethyl-6-methoxyquinolin-4-yl)propyl] -1- [3-(2,4,6-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(3-Morpholinomethyl-6-inethoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)-propyl]piperidine-4-acetic acid 4-[3-(3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)-propyl]piperidine-4-acetic acid 4-[3-(3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenylthio)-ethyl]piperidine-4-acetic acid 4- [3- (3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1-[2-(3,4,5-trifluorophenylthio)-ethyl]piperidine-4-acetic acid 4-[3-(3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenyl-amino)ethyl]piperidine-4-acetic acid 4- [3- (3-Morpholinoinethyl-6-methoxyquinolin-4-yl)propyl] -1-[2-(3,4,5-trifluorophenyl-amino)ethyl]piperidine-4-acetic acid 4- [3- (3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1-[2- (2, 4, 6-trifluoro-phenoxy)ethyl]piperidine-4-acetic acid 4- [3- (3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2-(3,4,5-trifluoro-phenoxy)ethyl]piperidine-4-acetic acid 4- [3- (3-Morpholinoinethyl-6-methoxyquinolin-4-yl)propyl] -1- [3-(2,4,6-trifluoro-phenyl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (3-Morpholinomethyl-6-rnethoxyquinolin-4-yl)propyl] -1- [3-(3,4,5-trifluoro-phenyl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-l-heptylpiperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [4-phenylbutyl] -piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(phenyl)propyl]-piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[4-(2-fluorophenyl)-propyl]piperidine-4-acetic acid 4- [3- (R,S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[4-(3-fluorophenyl)-propyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(4-fluorophenyl)-propyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[4-(4-fluorophenyl)-butyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3~(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [3- (2, 3-dif luoro-phenyl)propyl]piperidine-4- acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-!-[4-(2,3-difluoro-phenyl)propyl]piperidine-4- acetic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-5-methoxyquinolin-4- yDpropyl] -1- [3- (2, 6-difluoro-phenyl)propyl]piperidine-4- acetic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[4-(2,6-difluoro-phenyl)propyl]piperidine-4- acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyguinolin-4- yDpropyl] -1- [3- (3, 5-dif luoro-phenyl)propyl]piperidine-4- acetic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [3- (2,3, 5-trifluorophenyl)propyl]piperidine-4- acetic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-!-[3-(2,4,6-trifluorophenyl)propyl]piperidine-4- acetic acid 4-[3-{R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [3- (3, 4, 5-trifluorophenyl)propyl]piperidine-4- acetic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-phenylthio-propyl]piperidine-4-acetic acid 4- [3- (R, S)-Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl)propyl]-l-[3-(2-fluorophenylthio)propyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yDpropyl] -1- [3- (3-f luorophenylthio)propyl]piperidine-4-acetic acid 314-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yDpropyl] -1- [2- {4-f luorophenylthio) ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-l-[3-(4-fluorophenylthio)propyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,3-difluorophenylthio)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3-difluorophenylthio)propyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,6-difluorophenylthio)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-{3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenylthio)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenylthio)ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,4,5-trifluorophenylthio)ethyl]piperidine- 4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,5-difluorophenoxy)ethyl]piperidine-4- acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [2- (2,3, 5-trif luorophenoxy) ethyl ]piperidine-4- acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,4,6-trifluorophenoxy)ethyl]piperidine-4- acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4- acetic acid 4-[3-{R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,S-difluorophenylamino)ethyl]piperidine-4- acetic acid 4-[3-(R,S)-Hydroxy-3-{3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[2-(2,3,5- trifluorophenylamino)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-{3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[2-(2,4,6- trifluorophenylainino)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[2-(3,4,5- trifluorophenylainino)ethyl]piperidine-4-acetic acid 4- [3- {R,S)-Hydroxy-3- {3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,6-difluorophenylthio)propyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-{3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [2- (2-chlorophenyltliio) etllyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- {3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2-chlorophenylthio)propyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3-chlorophenylthio)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3-chlorophenylthio)propyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-{3-chloro-6-methoxyquinolin-4-yDpropyl] -1- [2- (4-chlorophenylthio) ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(4-chlorophenylthio)propyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-{2-methylphenylthio)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-{3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2-methylphenylthio)propyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [2- (3-methylphenylthio)ethyl]piperidine-4- acetic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [3- (3-methylphenylthio)propyl]piperidine-4- acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [2- (4-methylphenylthio) ethyl]piperidine-4- acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(4-methylphenylthio)propyl]piperidine-4- acetic acid 4-[3-(R,S)-Hydroxy~3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[2-{2- trifluoromethylphenylthio)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[3-{2- trifluoromethylphenylthio)propyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[2-(3- trifluoromethylphenylthio)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yDpropyl]-1-[3-(3- trifluoromethylphenylthio)propyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[2-(4- trifluoromethylphenylthio)ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[3-{4- trifluoromethylphenylthio)propyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [2- (2-methoxyphenylthio) ethyl]piperidine-4- acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(2-methoxyphenylthio)propyl]piperidine-4- acetic acid 4-[3-{R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [2- (3-methoxyphenylthio) ethyl]piperidine-4- acetic acid 4-[3-(R,S)-Hydroxy-3-{3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(3-methoxyphenylthio)propyl]piperidine-4- acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(4-methoxyphenylthio)ethyl]piperidine-4- acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(4-methoxyphenylthio)propyl]piperidine-4- acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[cyclopentylmethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [2- (cyclopentyl) ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(cyclohexyl)ethyl]piperidine-4-acetic acid I ( j 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(cyclopentylthio)ethyl3piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(cyclopentylthio)propyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [3- (cyclohexylthio)propyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(pyrid-2-yl)thioethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [4- (thien-2-yl)butyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(thien-2-yl)thiopropyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-inethoxyquinolin-4- yl)propyl]-1-[3-(thien-3-yl)propyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[4-(thien-3-yl)butyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [2- (thien-2-yl) thioethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [2- (thien-3-yl) thioethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(thien-3-yl)thiopropyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [3- (1, 3-thiazol-2-yl)propyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [4- (1, 3-thiazol-2-yl)butyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[3-(1,3-thiazol-2-yl)thioethyl]piperidine-4- acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(pyrid-2-yl)propyl]piperidine-4-acetic acid 4-[3-{R,S)-Hydroxy-3-{3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[4-(pyrid-2-yl)butyl]piperidine-4-acetic acid 4-[3-{R,S)-Hydroxy-3-{3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(pyrid-2-yl)thiopropyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(pyrid-3-yl)propyl]piperidine-4-acetic acid 4-[3-{R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [4- (pyrid-3-yl)butyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [2- {pyrid-3-yl) thioethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl)propyl]-1- [3- (pyrid-3-yl) thiopropyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yDpropyl] -1- [3- {pyrid-4-yl)propyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- {3-chloro-6-methoxyquinolin-4-yDpropyl] -1- [4- (pyrid-4-yl)butyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yDpropyl] -1- [2- (pyrid-4-yl) thioethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- {pyrid-4-yl) thiopropyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(pyrazin-2-yl)propyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[4-(pyrazin-2-yl)butyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(pyrazin -2-yl)thioethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yDpropyl] -1- [3- (pyrazin-2-yl) thiopropyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(4-fluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(3,4-difluorophenyl)prop-2-ynyl]piperidine- 4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,4-difluorophenyl)prop-2-ynyl]piperidine- 4-acetic acid 4- [3- (R,S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [3- (2,3, 5-trifluorophenyl)prop-2- ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [3- (2,4, 6-trifluorophenyl)prop-2- ynyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [3- (3,4, 5-trif luorophenyl)prop-2- ynyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [3- (4-chloro-3-f luorophenyl)prop-2- ynyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(3-chloro-4-fluorophenyl)prop-2- ynyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(2-chloro-4-fluorophenyl)prop-2- ynyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(3-chloro-5-fluorophenyl)prop-2- ynyl]piperidine-4-acetic acid 4- [3- (R,S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(4-chloro-2-fluorophenyl)prop-2- ynyl]piperidine-4-acetic acid 4-[3-(R/S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[3-(3-fluoro-4-methylphenyl)prop-2- ynyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[3-(3,5-bis(trifluoromethyl)phenyl)prop-2- ynyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(thien-2-yl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yl) propyl ] -1 - [ 3 - (thien-3 -yl) prop-2 -ynyl ] piperidine-4 -acetic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [3- (1, 3-thiazol-2-yl)prop-2-ynyl]piperidine-4- acetic acid 4- [3- (R,S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [3- (1, 3-thia2ol-4-yl)prop-2-ynyl]piperidine-4- acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [3- (1, 3-thia2ol-5-yl)prop-2-ynyl]piperidine-4- acetic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [3- (pyrid-2-yl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-!- [3- (pyrid-3-yl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-1- [3-(pyrid-4-yl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- {3-methyl-6-methoxyquinolin-4- yDpropyl] -1- [2- (cyclohexyl) ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-methyl-6-methoxyquinolin-4- yl)propyl]-!-[3-(phenyl)propyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-methyl-5-methoxyquinolin-4- yl)propyl]-!-[3-(2,3,5-trifluorophenyl)propyl]piperidine-4- acetic acid 4-[3-(R,S)-Hydroxy-3-(3-methyl-6-methoxyquinolin-4- yl)propyl]-!-[2-(3,S-difluorophenylamino)ethyl]piperidine-4- acetic acid 4-[3-(R,S)-Hydroxy-3-(3-methyl-6-methoxyquinolin-4- yl)propyl]-!-[2-(2,3,5- trifluorophenylamino)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-methyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,5-dif!uorophenoxy)ethyl]piperidine-4- acetic acid 4-[3-(R,S)-Hydroxy-3-(3-methyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,3,5-trifluorophenoxy)ethyl]piperidine-4- acetic acid 4- [3- (R, S) -Hydroxy-3- (3-methyl-6-methoxyquinolin-4-yl)propyl]-!-[2-(2,3,5-trifluorophenylthio)ethyl]piperidine-4-acetic acid 4- [3- (R,S) -Hydroxy-3- (3-methyl-6-methoxyquinolin-4-yl) propyl] -1- [2- (cyclopentylthio) ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-methyl-6-methoxyquinolin-4-yDpropyl] -1- [2- (pyrid-2-yl) thioethyl]piperidine-4-acetic acid 4- [3- (R,S) -Hydroxy-3- (3-methyl-6-methoxyquinolin-4-yl)propyl]-!- [2- (thien-2-yl) thioethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-methyl-6-methoxyquinolin-4-yDpropyl] -1- [3- (2, 3, 5-trif luorop]lenyl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-methyl-6-rnethoxyquinolin-4-yl)propyl] -1- [3- (thien-2-yl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-f luoro-6-methoxyquinolin-4-yDpropyl] -1- [2- (cyclohexyl)ethyl]piperidine-4-acetic acid 4- [3- (R,S) -Hydroxy-3- (3-f luoro-6-methoxyquinolin-4-yl)propyl]-1-[3-(phenyl)propyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-{3-fluoro-6-methoxyquinolin-4-yl)propyl]-!-[3-(2,3,5-trifluorophenyl)propyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-f luoro-6-methoxyquinolin-4-yl)propyl] -1-[2-(3,5-difluorophenylamino)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,3,5- trifluorophenylamino)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluorophenoxy)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,3,5-trifluorophenoxy)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenylthio)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(cyclopentylthio)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(pyrid-2-yl)thioethyl]piperidine-4-acetic acid 4- [3- (R,S) -Hydroxy-3- (3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(thien-2-yl)thioethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-{R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl] -1- [3- (thien-2-yl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-dimethylamino-6-methoxyquinolin-4-yDpropyl] -1- [2- (cyclohexyl) ethyl]piperidine-4-acetic acid 4- [3- (R,S) -Hydroxy-3- (3-dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [3- (phenyl)propyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)propyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-dimethylamino-6-methoxyquinolin-4-yl) propyl] -1- [2- (3, 5-dif luorophenylamino) ethyl] piper idine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,3,5- trif luorophenylamino) ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- {3-dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [2- (3, 5-dif luorophenoxy) ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-dimethylamino-6-methoxyquinolin-4-yl) propyl] -1- [2- (2, 3, 5-trif luorophenoxy) ethyl] piper idine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-!- [2- (2,3, 5-trifluorophenylthioethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- {3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[2-(cyclopentylthio)ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- {3-dimethylamino-5-methoxyquinolin-4-yl)propyl]-1-[2-{pyrid-2-yl)thioethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [2- (thien-2-yl) thioethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-dixnethylamino-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- {3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[3-(thien-2-yl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-Hydroxymethyl-6-methoxyquinolin-4-yDpropyl] -1- [2- (cyclohexyl) ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (phenyl)propyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)propyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluorophenylamino)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,3,5- trifluorophenylamino)ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-Hydroxymethyl-6-methoxyquinolin-4-yDpropyl] -1- [2- (3, 5-dif luorophenoxy) ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenoxy)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenylthio)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(cyclopentylthio)ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-!-[2-(pyrid-2-yl)thioethyl]piperidine-4-acetic acid 4- [3- (R,S)-Hydroxy-3- (3-Hydroxymethyl-6-methoxyquinolin-4-yDpropyl] -1- [2- (thien-2-yl) thioethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-hydroxymethyl-6-methoxyquinolin-4-yDpropyl] -1- [3- (2,3, 5-trif luorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (thien-2-yl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-{3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(cyclohexyl)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(phenyl)propyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)propyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-f luoroinethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (3, 5-dif luorophenylamino) ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,3,5- trifluorophenylamino)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yDpropyl] -1- [2- (3, 5-dif luorophenoxy) ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl] -1-[2-(2,3,5-trifluorophenoxy)ethyl]piperidine-4-acetic acid ) 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-!-[2-(2,3,5-trifluorophenylthio)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(cyclopentylthio)ethyl]piperidine-4-acetic 3 acid 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(pyrid-2-yl)thioethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-f luoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(thien-2-yl)thioethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-f luoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-f luoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(thien-2-yl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (cyclohexyl) ethyl]piperidine-4-acetic acid 4- [3- (R,S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(phenyl)propyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)propyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluorophenylamino)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,3,5-trifluorophenylamino)ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (3, 5-difluorophenoxy) ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (2, 3, 5-trif luorop]ienoxy) etllyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,3, 5-trif luorophenylthio)ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (cyclopentylthio)ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4-yDpropyl] -1- [2- (pyrid-2-yl) thioethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-aininomethyl-6-methoxyquinolin-4-yl)propyl]-l- [2- (t]iien-2-yl) tlaioethyl]piperidine-4-acetic acid 4- [3- (R,S) -Hydroxy-3- (3-aminomethyl-6-met]:ioxyquinolin-4-yl)propyl] -1- [3- (2,3, 5-trif luorop]aenyl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4-yDpropyl] -1- [3- (t]iien-2-yl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(cyclohexyl)ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(phenyl)propyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)propyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluorophenylamino)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5- trif luorophenylamino) ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethy-6-methoxyquinolin-4-yl)propyl] -1- [2- (3 , 5-dif luoroptienoxy) ethyl]piperidine-4~ acetic acid 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,3, 5-trif luorophenoxy) ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyll-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5- trifluorophenylthio) ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (cyclopentylthio) ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (pyrid-2-yl) thioethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (thien-2-yl) thioethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-!-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (thien-2-yl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-methyl-6-methoxyquinolin-4-yDpropyl] -1- [3- (2,4, 6-trifluorophenyl)propyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-methyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)propyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-methyl-6-methoxyquinolin-4-yl)Dpropyl] -1- [2- (2, 4, 6-trif luorophenylthio)ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenylthio)ethyl]piperidine-4-acetic acid 4- [3- (R,S) -Hydroxy-3- (3-met]iyl-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,4,6- trifluorophenylamino)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-methyl-6-rnethoxyquinolin-4-yl)propyl]-l-[2-(3,4,5-trifluorophenylamino)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-methyl-6-methoxyquinolin-4-yDpropyl] -1- [2- (2,4, 6-trif luorophenoxy) ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-methyl-6-methoxyquinolin-4-yDpropyl] -1- [3- (2,4, 6-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R,S)-Hydroxy-3- (3-methyl-6-methoxyquinolin-4-yDpropyl] -1- [3- (3, 4, 5-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl] -1- [3- (2,4,6-trifluorophenyl)propyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yDpropyl] -1- [3- (3,4, 5-trif luorophenyl) propyl ]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenylthio)ethyl]piperidine-4-acetic acid 4-[3-(R, S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yDpropyl] -1- [2- (3,4, 5-trif luorophenyl thio) ethyl ]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,4,6-trifluorophenylamino)ethyl]piperidine-4-acetic acid 4- [3- {R,S) -Hydroxy-3- (3-f luoro-6-methoxyquinolin-4-Yl)propyl]-l-[2-(3,4,5- trifluorophenylamino)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-{3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenoxy)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yDpropyl] -1- [2- (3,4, 5-trif luorophenoxy)ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-f luoro-6-methoxyquinolin-4-yDpropyl] -1- [3- (2,4, 6-trif luorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R,S)-Hydroxy-3- (3-f luoro-6-methoxyquinolin-4-yDpropyl] -1- [3- (3,4, 5-trif luorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-!-[3-(2,4,6-trifluorophenyl)propyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-dimethylamino-6-methoxyquinolin-4-yDpropyl] -1- [3- (3,4, 5-trifluorophenyl)propyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [2- (2, 4, 6-trif luorophenylthio) ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenylthio)ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-dimethylaruino-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,4,6- trifluorophenylamino)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-{3-dimethylamino-6-methoxyquinolin~4-yl)propyl]-l-[2-{3,4,5- trifluorophenylamino)ethyl]piperidine-4-acetic acid 4- [3- (R,S)-Hydroxy-3- (3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-l- [2- (2,4, 6-trifluorophenoxy)ethyl]piperidine-4-acetic acid 4- [3- (R,S) -Hydroxy-3- (3-dimethylainino-6-methoxyquinolin-4-yl)propyl]-l-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- {3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- {3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl1-1-[3-(3,4,5-trifluorophenyl)propyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenylthio)ethyl]piperidine-4-acetic acid 4-[3-{R,S)-Hydroxy-3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenylthio)ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,4,6- trifluorophenylamino)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-l-[2-(3,4,5- trifluorophenylaraino)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenoxy)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)propyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)propyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl] -1-[2-(2,4,6-trifluorophenylthio)ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-f luoromethyl-6-methoxyquinolin-4-yl)propyl]-1- [2-(3,4,5-trifluorophenylthio)ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-f luoromet]iyl-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,4,6- trifluorophenylamino)ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-f luoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3, 4, 5- trifluorophenylamino)ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-f luoromethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (2, 4, 6-trif luoroplienoxy) ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- {3-f luoromethyll-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-f luoromethyl-6-methoxyquinolin-4-yl)propyl]-!- [3- (2,4, 6-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yDpropyl] -1- [3- (3,4, 5-trif luorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-!-[3-(2,4,6-trifluorophenyl)propyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-!-[3-(3,4,5-trifluorophenyl)propyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenylthio)ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4-yDpropyl] -1- [2- (3,4, 5-trif luorophenylthio) ethyl jpiperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,4,6- trifluorophenylamino)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-l-[2-{3,4,5- trifluorophenylainino)ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenoxy)ethyl]piperidine-4-acetic acid 4- [3- (R,S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)propyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (3,4, 5-trifluorophenyl)propyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-mo3rpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6- trifluorophenylthio)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-l-[2-(3,4,5- trifluorophenylthio)ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-ruorpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,4,6- trifluorophenylamino)ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (3,4,5- trifluorophenylamino)ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenoxy)ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-l-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(R,S)-Hydroxy-3-(3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-l-[3-(3,4,5-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-{3-chloro-6-methoxyquinolin-4-yl)propyl]-l-heptylpiperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[4-phenylbutyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-raethoxyquinolin-4-yl)propyl]-l- [3- (phenyl)propyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yDpropyl] -1- [4- {2-f luorophenyl)propyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [4- (3-fluorophenyl)propyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-5-methoxyquinolin-4-yl)propyl]-l-[3-{4-fluorop]aenyl)propyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yDpropyl] -1- [4- (4-f luorophenyl)butyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yDpropyl] -1- [3- (2, 3-dif luorophenyl)propyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- {3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[4-(2,3-difluorop]lenyl)propyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yDpropyl] -1- [3- (2, 6-dif luorophenyl)propyl]piperidine-4-acetic acid 4- [3- (R,S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[4-(2,6-difluorophenyl)propyl]piperidine-4- acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[3-(3,5-difluorophenyl)propyl]piperidine-4- acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [3- (2,3, 5-trifluorophenyl)propyl]piperidine-4- acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,4,6-trifluorophenyl)propyl]piperidine-4- acetic acid 4-[3-(R,S)-Fluoro-3-{3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [3- (3,4, 5-trifluorophenyl)propyl]piperidine-4- acetic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [3-phenylthio-propyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[3-(2-fluorophenylthio)propyl]piperidine-4- acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(3-fluorophnylthio)propyl]piperidine-4- acetic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [2- (4-f luorophenylthio) etyl]piperidine-4- acetic acid 4- [3- (R, S) -Fluoro-3- {3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (4-f luorophenylthio)propyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,3-difluorophenylthio)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3-difluorophenylthio)propyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl) propyl] -1- [2- (2, 6-dif luorophenylthio)ethyl]piperidine-4-acetic acid 4- [3- (R,S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) propyl]-!- [2- (2, 3, 5-trifluorophenylthio) ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl) propyl] -1- [2- (2, 4, 6-trifluorophenyltliio) ethy]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl)propyl]-!-[2-(3,4,5-trifluorophenylthio)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yDpropyl] -1- [2- (3, 5-dif luorophenoxy) ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [2- (2, 3, 5-trif luoropllenoxy)etllyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenoxy)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [2- (3, 4, 5-trif luorophenoxy) et]lyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl)propyl]-!- [2- (3, 5-dif luorophenylamino) et]iyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,3,5- trifluorophenylamino)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,4,6- trifluorophenylamino)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-l-[2-(3,4,5- trifluorophenylamino)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,6-difluorophenylthio)propyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2-chlorophenylthio)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2-chlorophenylthio)propyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [2- (3-chlorophenylthio) ethyl]piperidine-4- acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [3- (3-chlorophenylthio)propyl]piperidine-4- acetic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyll-l- [2- (4-chlorophenylthio) ethyl]piperidine-4- acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [3- (4-chlorophenylthio)propyl]piperidine-4- acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[2-(2-methylphenylthio)ethyl]piperidine-4- acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(2-methylphenylthio)propyl]piperidine-4- acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [2- (3-methylphenylthio) ethyl]piperidine-4- acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [3- (3-methylphenylthio)propyl]piperidine-4- acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(4-methylphenylthio)ethyl]piperidine-4- acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(4-methylphenylthio)propyl]piperidine-4- acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[2-(2- trifluoromethylphenylthio)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[3-(2- trifluoromethylphenylthio)propyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[2-{3- trifluoromethylphenylthio)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[3-(3- trifluoromethylphenylthio)propyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[2-(4- trifluoromethylphenylthio)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[3-(4- trifluoromethylphenylthio)propyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-5-methoxyquinolin-4- yDpropyl] -1- [2- (2-methoxyphenylthio) ethyl]piperidine-4- acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(2-me thoxyphenylthio)propyl]piperidine-4- acetic acid 4- [3- (R, S) -Fluoro-3- {3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [2- (3-methoxyphenylthio)ethyl]piperidine-4- acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [3- {3-methoxyphenylthio)propyl]piperidine-4- acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[2-(4-methoxyphenylthio)ethyl]piperidine-4- acetic acid 4-[3-(R,S)-Fluoro-3-{3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(4-methoxyphenylthio)propyl]piperidine-4- acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [cyclopentylmethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [2- (cyclopentyl) ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1- [2- (cyclohexyl) ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [2- (cyclopentylthio) ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- {3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [3- (cyclopentylthio)propyl]piperidine-4-acetic acid 4-[3-{R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [3- (cyclohexylthio)propyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-!-[2-{pyrid-2-yl)thioethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[4-(thien-2-yl)butyl]piperidine-4-acetic acid 4-[3-{R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [3- (thien-2-yl) thiopropyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(thien-3-yl)propyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[4-(thien-3-yl)butyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [2- (thien-2-yl) thoethyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [2- (thien-3-yl) thioethyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [3- (thien-3-yl) thiopropyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(1,3-thiazol-2-yl)propyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [4- (1, 3-thiazol-2-yl)butyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(1,3-thiazol-2-yl)thioethyl]piperidine-4- acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(pyrid-2-yl)propyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[4-(pyrid-2-yl)butyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-]net]ioxyquinolin-4- yl)propyl] -1- [3- (pyrid-2-yl) thiopropyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(pyrid-3-yl)propyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [4- (pyrid-3-yl)butyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-met]aoxyquinolin-4- yl)propyl]-1-[2-(pyrid-3-yl)thioethyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-!- [3- (pyrid-3-yl) thiopropyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(pyrid-4-yl)propyl]piperidine-4-acetic acid 4- [3- (R,S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-!-[4-{pyrid-4-yl)butyl]piperidine-4-acetic acid 4- [3- (R,S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl] -!- [2- (pyrid-4-yl) thioethyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) propyl] -1- [3- (pyrid-4-yl) thiopropyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) propyl] -1- [3- (pyrazin-2-yl)propyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[4-(pyrazin-2-yl)butyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [2- (pyrazin-2-yl) thioethyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl)propyl]-l- [3- (pyrazin-2-yl) thiopropyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(4-fluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4-difluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4-difluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (2,3, 5-trif luorop]lenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-{3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(4-chloro-3-fluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3-chloro-4-fluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-!- [3- (2-chloro-4-fluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (3-chloro-5-f luorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (4-chloro-2-f luorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl)propyl]-1- [3- (3-f luoro-4-methylphenyl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (3, 5-bis (trif luorometllyl)phenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(thien-2-yl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(thien-3-yl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-!-[3-(1,3-thiazol-2-yl)prop-2-ynyl]piperidine-4- acetic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(1,3-thiazol-4-yl)prop-2-ynyl]piperidine-4- acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(1,3-thiazol-5-yl)prop-2-ynyl]piperidine-4- acetic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- y1)propyl]-1-[3-(pyrid-2-yl)prop-2-yny1]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(pyrid-3-yl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [3- (pyrid-4-yl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-methyll-6-methoxyquinolin-4- yl)propyl]-1- [2- (cyclohexyl) ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4- yl)propyl]-1-[3-(phenyl)propyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,3,5-trifluorophenyl)propyl]piperidine-4- acetic acid 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,5-difluorophenylamino)ethyl]piperidine-4- acetic acid 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4- yl)propyl]-l-[2-(2,3,5- trifluorophenylamino)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,5-difluorophenoxy)ethyl]piperidine-4- acetic acid 4-[3-(R,S)-Fluoro-3-(3-inethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,3,5-trifluorophenoxy)ethyl]piperidine-4- acetic acid 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(cyclopentylthio)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(pyrid-2-yl)thioethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4- yDpropyl] -1- [2- (thien-2-yl) thioethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4-yDpropyl] -1- [3- (thien-2-yl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(R/S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(cyclohexyl)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[3-(phenyl)propyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-l-[3-(2,3,5-trifluorophenyl)propyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-5-methoxyquinolin-4-yl)propyl]-l-[2-(3,5-difluorophenylamino)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl] -1- [2- (2, 3 , 5- trifluorophenylamino)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluorophenoxy)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenoxy)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4- yDpropyl] -1- [2- (2,3, 5-trif luorophenylthio)ethyl]piperidine- 4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4- yl)propyl]-l-[2-(cyclopentylthio)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4- yl)propyl]-1-[2-(pyrid-2-yl)thioethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4- yl) propyl] -1- [2- (thien-2-yl) thioethyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-f luoro-6-methoxyquinolin-4- yl)propyl] -1- [3- (2,3, 5-trif luorophenyl)prop-2- ynyl]piperidine-4-acetic acid 4- [3- (R,S)-Fluoro-3- (3-f luoro-6-methoxyquinolin-4- yl)propyl] -1- [3- (t]iien-2-yl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-dimethylamino-6-methoxyquinolin-4- yl)propyl] -1- [2- (cyclohexyl) ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-dimethylamino-6-methoxyquinolin-4- yl)propyl]-1-[3-(phenyl)propyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-dimethylamino-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,3,5-trifluorophenyl)propyl]piperidine-4- acetic acid 4-[3-{R,S)-Fluoro-3-(3-dimethylamino-6-methoxyquinolin-4- yl) propyl] -1- [2- (3, 5-dif luorophenylamino) ethyl]piperidine-4- acetic acid 4- [3- (R, S) -Fluoro-3- (3-dimethylamino-6-methoxyquinolin-4- yl)propyl]-l-[2-{2,3,5- trifluorophenylartdno)ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-dimethylamino-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,5-difluorophenoxy)ethyl]piperidine-4- acetic acid 4- [3- (R, S) -Fluoro-3- (3-dimethylamino-6-methoxyquinolin-4- yl)propyl]-l-[2-(2,3,5-trifluorophenoxy)ethyl]piperidine-4- acetic acid 4- [3- (R, S) -Fluoro-3- (3-dimethylamino-6-methoxyquinolin-4- yl)propyl]-l- [2- (cyclopentylthio)ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-dimethylamino-6-methoxyquinolin-4- yl)propyl]-1-[2-{pyrid-2-yl)thioethyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-dimethylamino-6-methoxyquinolin-4- yl)propyl]-1-[2-(thien-2-yl)thioethyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- {3-dimethylaruino-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,3,5-trifluorophenyl)prop-2- ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-dimethylamino-6-methoxyquinolin-4- yl)propyl] -1- [3- (thien-2-yl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-hydroxymethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(cyclohexyl)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-hydroxymethyl-6-methoxyquinolin-4- yl)propyl]-1-[3-(phenyl)propyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-hydroxymethyl-6-methoxyquinolin-4- yl)propyl]-!-[3-(2,3,5-trifluorophenyl)propyl]piperidine-4- acetic acid 4- [3- (R,S)-Fluoro-3- (3-]iydroxymethyll-6-methoxyquinolin-4- yl)propyl]-!-[2- (3, S-difluorophenylamino) ethyl]piperidine-4- acetic acid 4- [3- (R,S)-Fluoro-3- (3-hydroxymethyl-6-methoxyquinolin-4- yl)propyl]-l-[2-{2,3,5- trifluorophenylamino)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-hydroxymethyl-6-methoxyquinolin-4- yDpropyl] -1- [2- (3, 5-difluorophenoxy) ethyl]piper idine-4- acetic acid 4- [3- (R,S)-Fluoro-3- (3-hydroxymethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,3,5-trifluorophenoxy)ethyl]piperidine-4- acetic acid 4-[3-(R,S)-Fluoro-3-(3-hydroxymethyl-6-methoxyquinolin-4- yDpropyl] -1- [2- (2,3, 5-trif luorophenylthio)ethyl]piperidine- 4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-hydroxymethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(cyclopentylthio)ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(pyrid-2-yl)thioethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(thien-2-yl)thioethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-Hydroxymethyl-6-methoxyquinolin-4-yl) propyl] -1- [3- (t]iien-2-yl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-f luoromethyl-6-methoxyquinolin-4-yDpropyl] -1- [2- (cyclohexyl) ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(phenyl)propyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-f luoromethyll-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)propyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-l- [2- (3, 5-dif luorophenylamino) etllyl]piperidine-4-acetic acid 4- [3- (R,S)-Fluoro-3- (3-f luoroinethyl-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,3,5-trifluorophenylamino)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl] -1- [2-(3,5-difluorophenoxy)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4-yDpropyl] -1- [2- (2, 3, 5-trif luorophenylthio)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4-yDpropyl] -1- [2- (cyclopentylthio) ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-f luoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(pyrid-2-yl)thioethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl] -1-[2-(thien-2-yl)thioethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl] -1-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(R;S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(thien-2-yl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-arninomethyl-6-methoxyquinolin-4-yl)propyl]-1- [2- (cyclohexyl) ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-aminomethyl-6-methoxyquinolin-4-yDpropyl] -1- [3- (phenyl)propyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)propyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-!-[2-(3,5-difluorophenylamino)etllyl]piperidine-4-acetic acid 4- [3- (R,S)-Fluoro-3- (3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,3,5- trifluorophenylamino)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-aininomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluorophenoxy)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenoxy)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenylthio)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(cyclopentylthio)ethyl]piperidine-4-acetic acid 4- [3- (R,S)-Fluoro-3- (3-aininomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(pyrid-2-yl)thioethyl]piperidine-4-acetic acid 4- [3-(R,S)-Fluoro-3- (3-aminomethyl-6-methoxyquinolin-4-yDpropyl] -1- [2- (thien-2-yl) thioethyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3 -{thien-2-yl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-inorpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(cyclohexyl)ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-morpholinomethyll-6-methoxyquinolin-4-yl)propyl] -1- [3- (phenyl)propyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-morpholinomethyll-6-methoxyquinolin-4-yl)propyl]-l-[3-(2,3,5-trifluorophenyl)propyl]piperidine-4-acetic acid 4- [3- (R,S)-Fluoro-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl) propyl] -1- [2- (3, S-difluorophenylamino) etllyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-morpliolinomethyl-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,3,5- trifluorophenylamino) et]iyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-morpholinomethyll-6-methoxyquinolin-4-yl) propyl]-l- [2- (3, 5-dif luorophenoxy) ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenoxy)ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- {3-morpholinomethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,3,5-trifluorophenylthio)ethyl]piperidine- 4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-morpholinomethyl-6-methoxyquinolin-4- yl)propyl]-l-[2-(cyclopentylthio)ethyl]piperidine-4-acetic acid 4- [3, (R, S) 'Fluoro-3- (3-morpholinomethyl-6-methoxyquinolin-4~ yDpropyl] -1- [2- (pyrid-2-yl) thioethyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-morpholinomethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(thien-2-yl)thioethyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-morpholinomethyl-6-methoxyquinolin-4- yDpropyl] -1- [3- (2, 3, 5-trifluorophenyl)prop-2- ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-morpholinomethyl-6-methoxyquinolin-4- yl)propyl] -1- [3- {thien-2-yl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,4,6-trifluorophenyl)propyl]piperidine-4- acetic acid 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4- yl)propyl]-!-[3-(3,4,5-trifluorophenyl)propyl]piperidine-4- acetic acid 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,4,6-trifluorophenylthio)ethyl]piperidine- 4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-methyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (3,4, 5-trif luorophenylthio) ethyl]piperidine-4-acetic acid 4- [3- (R, S)-Fluoro-3- (3-methyl-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,4,6- trifluorophenylamino)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-inethyl-6-methoxyquinolin-4-yl)propyl]-l-[2-(3,4,5- trifluorophenylamino)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenoxy)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4-yl)propyl]-!-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4-yDpropyl] -1- [3- (3,4, 5-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-!-[3-(2,4,6-trifluorophenyl)propyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl] -1- [3-(3,4,5-trifluorophenyl)propyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-!-[2-(2,4,6-trifluorophenylthio)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-{3-fluoro-6-methoxyquinolin-4-yl) propyl]-1- [2- (3,4, 5-trifluorophenyltliio) ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,4,6- trifluorophenylamino)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl] -1- [2- (3, 4, 5- trifluorophenylamino)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yDpropyl] -1- [2- (2, 4, 6-trifluorophenoxy)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yDpropyl] -1- [3- (2,4, 6-trif luorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-!-[3-(3,4,5-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)propyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-!-[3-(3,4,5-trifluorophenyl)propyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,4, 6-trif luorophenylthio) ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [2- (3, 4, 5-trifluorophenylthio)ethyl]piperidine-4-acetic acid 4- [3- (R,S)-Fluoro-3- (3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,4,6- trifluorophenylamino) ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-l-[2-(3,4,5- trifluorophenylamino) ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenoxy)ethyl]piperidine-4-acetic acid 4- [3- (R,S)-Fluoro-3- (3-dimethylamino-6-methoxyquinolin-4-yDpropyl] -1- [2- (3,4, 5-trif luoroplienoxy)etmyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-dimethylamino-6-methoxyquinolin-4-yDpropyl] -1- [3- (2,4, 6-trif luorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-dimetmylamino-6-methoxyquinolin-4-yl)propyl]-!- [3- (3,4, 5-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-!-[3-(2,4,6-trifluorophenyl)propyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)propyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-!-[2-(2,4,6-trifluorophenyltliio)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-!-[2-(3,4,5-trif!uorophenylthio)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-!-[2-(2,4,6- trifluorophenylamino)ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-l-[2-(3,4,5- trifluorophenylamino)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-!-[2-(2,4,6-trifluorophenoxy)ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-!-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-!-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4-yDpropyl] -1- [3- (2, 4, 6-trifluorophenyl)propyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-!-[3-(3,4,5-trifluorophenyl)propyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-f luoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenylthio)ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-f luoromethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (3,4, 5-trifluorophenylthio) ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-f luoromethyl-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,4,6- trifluorophenylamino)ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-f luoromethyl-6-methoxyquinolin-4-yl)propyl]-l-[2-(3,4,5- trifluorophenylamino)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenoxy)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4-acetic acid 4- [3- (R, S)-Fluoro-3- (3-f luoromethyl-6-methoxyquinolin-4-yl)propyl]-!-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-!-[3-(3,4,5-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)propyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-!-[3-(3,4,5-trifluorophenyl)propyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (2, 4, 6-trifluorophenyltliio) ethylJpiperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-aminomethyll-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenylthio)ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-!-[2-(2,4,6- trifluorophenylamino)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-!-[2-(3,4,5- trifluorophenylamino)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-!-[2-(2,4,6-trifluorophenoxy)ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-1- [2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-{3-aminomethyl-6-methoxyquinolin-4-yDpropyl] -1- [3- (2,4, 6-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-aminomethyl-6-methoxyquinolin-4-yDpropyl] -1- [3- (3,4, 5-trif luorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-morpholinomethyl-6-methoxyquinolin-4-yDpropyl] -1- [3- (2,4, 6-trifluorophenyl)propyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-l- [3- (3, 4, 5-trif luorophenyl)propyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (2, 4, 6-trifluorophenylthio)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-morpholinomethyl-6-methoxyquinolin-4-yDpropyl] -1- [2- (3,4, 5-trif luorophenylthio)ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,4,6- trifluorophenylamino)ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-inorpholinomethyl-6-methoxyquinolin-4-yl)propyl]-l-[2-(3,4,5-trifluorophenylamino)ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-morpholinomethyl-6-methoxyquinolin-4-yDpropyl] -1- [2- (2,4, 6-trifluorophenoxy)ethyl]piperidine-4-acetic acid 4-[3-(R,S)-Fluoro-3-(3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4- [3- (R, S) -Fluoro-3- {3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)prop-2-ynyl]piperidine-4-acetic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-heptylpiperid-4-ylmethanol 4- [3- (3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- [4-phenylbutyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[4-(2-fluorophenyl)propyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[4-(3-fluorophenyl)propyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(4-fluorophenyl)propyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[4-(4-fluorophenyl)butyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3-dif luorophenyl) propyl ] piperid-4-ylxnethanol 4- [3- {3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- [4- (2,3- difluorophenyl) propyl ] piperid-4-ylmethanol 4- [3- (3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (2, 6- dif luorophenyl) propyl ]piperid-4-ylmethanol 4- [3-(3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- [4- (2, 6- difluorophenyl)propyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-l-[3-(3,5- di fluorophenyl)propyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-l-[3-(2,3, 5- trifluorophenyl)-propyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6- trifluorophenyl)-propyl]piperid-4-ylmethanol 4- [3- (3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- {3,4,5- trifluorophenyl)-propyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-xnethoxyquinolin-4-yl)propyl]-1-[3- phenylthiopropyl]piperid-4-ylmethanol 4-[3-{3-Chloro-6-methoxyqainolin-4-yl)propyl]-1-[3-(2- fluorophenylthio)propyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3- fluorophenylthio)propyl]piperid-4-ylmethanol 4-[3-{3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(4- fluorophenylthio)ethyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(4- fluorophenylthio)propyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,3- difluorophenyl-thio)ethyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3- difluoropheny1-thio)propyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,6- difluorophenyl-thio)ethyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,3,5- trifluorophenyl-thio)ethyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,4,6- trifluorophenyl-thio)ethyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-l-[2-(3,4,5- trifluorophenyl-thio)ethyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5- trifluorophenoxy)-ethyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6- trifluorophenoxy)-ethyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5- trifluorophenoxy)-ethyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-l-[2-(3,5- difluorophenylamino)-ethyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5- trifluorophenylamino)-ethyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,4,6- trifluorophenylamino)-ethyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5- trifluorophenylamino)-ethyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,6- difluorophenylthio)-propyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-l-[2-(2-chlorophenylthio)ethyl]piperid-4-ylmethanol 4-[3-{3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2-chlorophenylthio) propyl ] piperid-4-ylmethanol 4-[3-{3-Chloro-6-methoxyquinolin-4-yl)propyll-1-[2-(3-chlorophenylthio)ethyl]piperid-4-ylmethanol 4-[3-{3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3-chlorophenylthio) propyl ] piperid-4-ylmethanol 4- [3- (3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- [2- (4-chlorophenyl thio) ethyl ] piper id-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(4-chlorophenylthio)propyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-!-[2-(2-methylphenylthio) ethyl] piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2-methylphenylthio)propyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3-me thylphenylthio) ethyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3-methyIphenylthio)propyl]piperid-4-ylmethanol 4-[3-{3-Chloro-6-methoxyquinolin-4-yl)propyl]-l-[2-(4-methylphenylthio)ethyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(4-methylphenylthio)propyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2-trifluoromethylphenylthio) -ethyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2-trifluoromethylphenylthio)-propyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3-trifluoromethylphenylthio)-ethyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3-trifluoromethylphenylthio)-propyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(4-trifluoromethylphenylthio)-ethyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(4-trifluoromethyIpheny1thio)-propyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2-methoxyphenylthio)ethyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2-methoxyphenylthio) -propyl] piper id-4-y Imethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1- [2- (3-methoxyphenylthio)ethyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3-methoxyphenylthio) -propyl ] piper id-4-y Imethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(4-methoxyphenylthio) ethyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(4-methoxyphenylthio) -propyl] piperid-4-y Imethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-l-[cyclopentylmethyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(cyclopentyl)ethyl]piperid-4-ylmethanol 4- [3- (3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- [2-(cyclopentylthio) ethyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(cyclopentylthio) propyl ] piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-( cyclohexyl thio ) propyl ] piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[4-(thien-2- yl)butyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(thien-2- yl)thiopropyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(thien-3- yl) propyl ] piperid-4-ylmethanol 4- [3- (3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- [4- (thien-3- yl) butyl ] piperid-4-ylmethanol 4- [3- (3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- [2- (then-3- yl) thioethyl]piperid-4-ylinet]ianol 4- [3- (3-Chloro-6-met]aoxyquinolin-4-yl)propyl] -1- [3- (thien-3- yl) thiopropyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(1,3- thiazol-2-yl) propyl ] piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[4-(1,3- thiazol-2-yl) butyl ]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(1,3- thia2ol-2-yl)thioethyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(pyrid-2- yl)propyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[4-(pyrid-2- yl)butyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(pyrid-2- yl)thiopropyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(pyrid-3- yl) propyl ] piper id-4-ylmethanol 4-[3-{3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[4-(pyrid-3- yl) butyl ] piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(pyrid-3- yl) thioethyl ] piperid-4-ylmethanol 4-[3-(3-Chloro-6-xnethoxyquinolin-4-yl)propyl]-1-[3-(pyrid-3- yl) thiopropyl ] piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-{pyrid-4- yl) propyl ] piperid-4-ylmethanol 4- [3- (3-Chloro-6-methoxyquinolin-4-yl) propyl] -1- [4- (pyrid-4- yl)butyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(pyrid-4- yl) thioethyl ] piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(pyrid-4- yl) thiopropyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(pyrazin- 2-yl)propyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[4-(pyrazin- 2-y1)butyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2- (pyrazin-2-yl)thioethyl]piperid-4-ylmethanol 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(pyrazin-2-yl) thiopropyl ] piper id- 4-ylmethanol 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(4-f luorophenyl) prop-2 -ynyl ] piperid-4-ylmethanol 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (3,4-dif luorophenyl) prop-2-ynyl ] piperid-4-ylmettianol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4-dif luorop]ienyl ) prop-2 -ynyl ] piperid-4-ylmethanol 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl]-!- [3- (2,3, 5-trifluorophenyl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trif luorophenyl) prop-2-ynyl ] piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3- (3,4,5-tr if luorophenyl) prop-2-ynyl ] piper id-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3- (4-chloro-3-fluorophenyl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3-chloro-4-fluorophenyl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2-chloro-4-fluorophenyl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3-chloro-5-fluorophenyl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(4-chloro-2-f luorophenyl) prop-2-ynyl] piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3-fluoro-4-methylpheny1)prop-2-ynyl]piperid-4-ylmethanol 4-[3-{3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,5- bis(trifluoromethyll)phenyl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-{3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(thien-2- y1)prop-2-yny1]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(thien-3- yl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(1,3- thiazol-2-yl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-{3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(1,3- thiazol-4-yl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(1,3- thiazol-5-yl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(pyrid-2- yl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(pyrid-3- yl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(pyrid-4- yl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(cyclohexyl)ethyl]piperid-4-ylmethanol 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[3-( pheny 1 ) propy 1 ] piper id- 4 -ylmethanol 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-!-[3-(2,3,5- trifluorophenyl)propyl]piperid-4-ylmethanol 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5- difluorophenylamino) ethyl ] piperid-4-ylmethanol 4- [3- (3-Methyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,3,5- trif luorophenylamino) ethyl]piperid-4-ylmethanol 4- [3- {3-Met]iyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (3, 5- difluorophenoxy)ethyl]piperid-4-ylmethanol 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5- trifluorophenoxy)-ethyl]piperid-4-ylmethanol 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[2- (cyclopentylthio)ethyl]piperid-4-ylmethanol 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(pyrid-2- yl) thioethyl]piperid-4-ylmethanol 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1- [2- (thien-2- yl)thioethyl]piperid-4-ylmethanol 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5- trifluorophenyl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(thien-2- y1)prop-2-yny1]piperid-4-ylmethanol 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2- (cyclohexyl)ethyl]piperid-4-ylmethanol 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[3- (phenyl)propyl]piperid-4-ylmethanol 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5- trifluorophenyl)-propyl]piperid-4-ylmethanol 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5- difluorophenyl-amino)ethyl]piperid-4-ylmethanol 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5- trifluorophenyl-amino)ethyl]piperid-4-ylmethanol 4-[3-(3-Fluoro-5-methoxyquinolin-4-yl)propyl]-1-[2-(3,5- difluorophenoxy)ethyl]piperid-4-ylmethanol 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5- trif luorophenoxy) -ethyl]piperid-4-ylmethanol 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5- trifluorophenylthio)-ethyl]piperid-4-ylmethanol 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2- (cyclopentylthio) ethyl]piperid-4-ylmethanol 4- [3- (3-Fluoro-6-methoxyquinolin-4-yl)propyl]-!- [2- (pyrid-2- yl) thioethyl ] piperid-4-ylmethanol 4- [3- (3-Fluoro-6-methoxyquinolin-4-yl)propyl] -1- [2- (thien-2- yl) thioethyl ] piperid-4-ylmethanol 4- [3- (3-Fluoro-6-methoxyquinolin-4-yl)propyl] -1 [3- (2,3,5- trif luorophenyl) prop-2-ynyl ] piperid-4-ylmethanol 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[3-(thien-2- yl) prop-2-ynyl ] piperid-4-ylmethanol 4- [3- (3-Dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [2- (cyclohexyl) ethyl] piperid-4-ylmethanol 4-[3-(3-Dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[3- (phenyl)propyl]piperid-4-ylmethanol 4- [3- (3-Dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [3- (2,3,5-trifluorophenyl)propyl]piperid-4-ylmethanol 4- [3- (3-Dimethylainino-6-methoxyquinolin-4-yl)propyl] -1- [2- (3, 5-dif luoro-phenylamino) ethyl]piperid-4-ylmethanol 4- [3- (3-Dimethylainino-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,3,5-trifluoro-phenylamino)ethyl]piperid-4-ylmethanol 4- [3- {3-Dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [2-(3,5-difluorophenoxy)-ethyl]piperid-4-ylmethanol 4- [3- (3-Dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [2-(2,3, 5-trif luorophenoxy) -ethyl]piperid-4-ylmethanol 4- [3- {3-Dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [2-(2,3, 5-trifluorophenylthio) -ethyl]piperid-4-ylmethanol 4- [3- (3-Diinethylamino-6-methoxyquinolin-4-yl)propyl] -1- [2-(cyclopentylthio) -ethyl ]piperid-4-ylmethanol 4-[3-(3-Dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[2-(pyrid-2-yl)thioethyl]-piperid-4-ylmethanol 4-[3-(3-Dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[2-(thien-2-yl)thioethyl]-piperid-4-ylmethanol 4- [3- (3-Diinethylainino-6-methoxyquinolin-4-yl)propyl] -1- [3-(2,3,5-trifluorophenyl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(3-Dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[3-(thien-2-yl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(cyclohexyl)ethyl]piperid-4-ylmethanol 4- [3- (3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-l- [3-(phenyl) propyl] piper id-4-ylmethanol 4- [3- (3-HydroxyTnethyl-6-methoxyquinolin-4-yl)propyl] -1- [3-(2,3, 5-trif luorophenyl) -propyl]piperid-4-ylmethanol 4- [3- (3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl] -1- [2-(3, 5-dif luorophenyl amino) -ethyl ]piperid-4-ylmethanol 4- [3- (3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl] -1- [2-(2, 3, 5-trif luorophenylamino) -ethyl]piperid-4-ylmethanol 4- [3- (3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl] -1- [2-(3, 5-dif luorophenoxy) -ethyl]piperid-4-ylmethanol 4- [3- (3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl] -1- [2-(2,3/ 5-trif luoroplienoxy) -ethyl]piperid-4-ylmethanol 4- [3- (3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl] -1- [2-(2,3, 5-trif luorophenylthio) -ethyl]piperid-4-ylmethanol 4- [3- (3-Hydroxymethyll-6-methoxyquinolin-4-yl)propyl] -1- [2-(cyclopentylthio) -ethyl]piperid-4-ylmetlaanol 4- [3- (3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl] -1- [2-(pyrid-2-yl) thio-ethyl]piperid-4-ylmethanol 4- [3- (3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl] -1- [2-{thien-2-yl) thio-ethyl] piperid-4-ylmethanol 4- [3- (3-Hydroxymethyl-6-methooxyquinolin-4-yl)propyl] -1- [3-(2,3, 5-trifluorophenyl)prop-2-ynyl]piperid-4-ylmettianol 4- [3- (3-Hydroxymethyl-6-inethoxyquinolin-4-yl)propyl] -1- [3-(thien-2-yl)prop-2-ynyl] -piperid-4-ylmethanol 4- [3- (3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl] -1- [2-(cyclohexyl) ethyl ] piperid-4-ylmethanol 4- [3- (3-Fluoromethyll-6-methoxyquinolin-4-yl)propyl] -1- [3-(plienyl) propyl ] piperid-4-ylmethanol 4- [3- (3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl] -1- [3-(2, 3, 5-trifluorophenyl)propyl]piperid-4-ylmethanol 4- [3- (3-Fluoromethyll-6-methoxyquinolin-4-yl)propyl] -1- [2-(3, 5-dif luorophenyl-amino) ethyl]piperid-4-ylmethanol 4- [3- (3-Fluoromethyll-6-met]hxyquinolin-4-yl)propyl] -1- [2-(2,3, 5-trif luorophenyl-amino) ethyl]piperid-4-ylmethanol 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2- (3,5-difluorophenoxy)-ethyl]piperid-4-ylmethanol 4-[3-{3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2- (2,3,5-trifluorophenoxy)-ethyl]piperid-4-ylmethanol 4- [3- {3-Fluoromethyl-6-methoxyquinolin-4-yl) propyl] -1- [2- (2,3,5-trifluorophenylthio)-ethyl]piperid-4-ylmethanol 4- [3- (3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (cyclopentylthio) ethyl] -piperid-4-ylmethanol 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2- (pyrid-2-yl)thioethyl]piperid-4-ylmethanol 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2- (thien-2-yl)thioethyl]piperid-4-ylmethanol 4-[3-(3-Fluoroinethyl-6-methoxyquinolin-4-yl)propyl]-1-[3- (2,3,5-trifluorophenyl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[3- (thien-2-yl)prop-2-ynyl]piperid-4-ylmethanol 4- [3- (3-AiTiinoinethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (cyclohexyl) ethyl] piper id-4-ylmethanol 4- [3- (3-Aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (phenyl)propyl]piperid-4-ylmethanol 4- [3- (3-Aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (2,3, 5-trif luorophenyl) -propyl]piperid-4-ylmethanol 4- [3- (3-Aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (3, 5-dif luorophenylamino) -ethyl]piperid-4-ylmethanol 4- [3- (3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-l- [2- (2,3,5-trifluorophenylamino)-ethyl]piperid-4-ylmethanol 4- [3- (3-Aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (3, 5-dif luorophenoxy) -ethyl]piperid-4-ylmethanol 4- [3- (3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-1- [2- (2,3, 5-trif luorophenoxy) -ethyl]piperid-4-ylmethanol 4- [3- (3-Aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,3, 5-trif luorophenylthio) -ethyl]piperid-4-ylmethanol 4- [3- (3-Aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (cyclopentylthio)-ethyl]piperid-4-ylmethanol 4- [3- (3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-!- [2- (pyrid-2-yl) thioethyl]piperid-4-ylmethanol 4- [3- (3-Aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (thien-2-yl) thioethyl]piperid-4-ylmethanol 4- [3- (3-Aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (2,3, 5-trif luorophenyl)prop-2-ynyl]piperid-4-ylmethanol 4- [3- (3-Aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (thien-2-yl)prop-2-ynyl]piperid-4-ylmethanol 4- [3- (3-Morpholinoinethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (cyclohexyl) -ethyl] piper id-4-ylmethanol 4- [3- (3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [3-(phenyl)propyl]piperid-4-ylmethanol 4-[3-(3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1- [3-(2,3,5-trifluorophenyl)-propyl]piperid-4-ylmethanol 4- [3- (3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2-(3,5-difluorophenylamino)ethyl]piperid-4-ylmethanol 4- [3- (3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,3, 5-trifluorophenyl-amino)ethyl]piperid-4-ylmethanol 4- [3- (3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2-(3,5-difluorophenoxy)-ethyl]piperid-4-ylmethanol 4-[3-(3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1- [2-(2,3,5-trifluorophenoxy)-ethyl]piperid-4-ylmethanol 4-[3-(3-M03rpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1- [2-(2,3,5-trifluorophenyl-thio)ethyl]piperid-4-ylmethanol 4- [3- (3-Moi:pholinoinethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (cyclopentylthio) -ethyl]piperid-4-ylmethanol 4- [3- (3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (pyrid-2-yl) thioethyl] -piperid-4-ylmethanol 4- [3- (3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (thien-2-yl) thioethyl] -piperid-4-ylmethanol 4- [3- (3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [3-(2,3,5-trifluoro-phenyl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1- [3- (thien-2-yl) prop-2-ynyl] piperid-4-ylmethanol 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-l-[3-(2,4,6- trifluoro-phenyl)propyl]piperid-4-ylmethanol 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5- trifluoro-phenyl)propyl]piperid-4-ylmethanol 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6- trifluorophenyl-thio)ethyl]piperid-4-ylmethanol 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5- trifluorophenylthio)-ethyl]piperid-4-ylmethanol 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6- trifluorophenylamino)-ethyl]piperid-4-ylmethanol 4- [3- (3-Methyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (3, 4, 5- trif luorophenylamino) -ethyl]piperid-4-ylmethanol 4- [3- (3-Methyl-6-methoxyquinolin-4-yl)propyl]-!- [2- (2,4, 6- trif luorophenoxy) -ethyl]piperid-4-ylmethanol 4- [3- (3-methyll-6-methoxyquinolin-4-yl)propyl] -1- [2- (3, 4, 5- trif luorophenoxy) -ethyl]piperid-4-ylmethanol 4- [3- (3-Methyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (2,4, 6- trif luorophenyl)prop-2-ynyl]piperid-4-ylmethanol 4- [3- (3-Methyl-6-methoxyquinolin-4-yl)propyl]-!- [3- (3,4, 5- trif luorophenyl) prop-2-ynyl ] piper id-4-ylmethanol 4- [3- (3-Fluoro-6-methoxyquinolin-4-yl)propyl] -1- [3- (2,4, 6- trif luoroplienyl) -propyl] piperid-4-ylmethanol 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1- [3- (3,4,5- trifluoroplienyl)-propyl]piperid-4-ylmethanol 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6- trif luorophenylthio) -ethyl] piper id-4-ylmethanol 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-!-[2-(3,4,5- trifluorophenylthio) -ethyl]piperid-4-ylmethanol 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6- trifluorophenyl-ainino)ethyl]piperid-4-ylmethanol 4-[3-(3-Fluoro-6-mettioxyquinolin-4-yl)propyl]-1-[2-(3,4,5- tri£luorop]ienyl-amino)ethyl]piperid-4-ylmethanol 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,4,6- trif luoroplienoxy) -ethyl]piperid-4-ylrmethanol 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5- trif luoroplienoxy) -ethyl] piperid-4-ylmethanol 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6- trifluorophenyl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5- trifluorophenyl)prop-2-ynyl]piperid-4-ylmethanol 4- [3- (3-Dimethylaxnino-6-methoxyquinolin-4-yl)propyl] -1- [3- (2,4,6-trifluorophenyl)-propyl]piperid-4-ylmethanol 4- [3- (3-Dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [3- (3,4, 5-trif luorophenyl) -propyl]piperid-4-ylmethanol 4- [3- (3-Dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,4, 6-trif luoroplienyl-thio) ethyl] piper id-4-ylmethanol 4- [3- (3-Dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [2- (3,4,5-trifluoroplienyl-thio)ethyl]piperid-4-ylmethanol 4-[3-{3-Dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[2- (2,4,6-trifluorophenyl-amino)ethyl]piperid-4-ylmethanol 4-[3-(3-Dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[2- (3,4,5-trifluorophenyl-amino)ethyl]piperid-4-ylmethanol 4- [3- (3-Dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,4, 6-trif luorophenoxy) -ethyl]piperid-4-ylmethanol 4- [3- (3-Dimethylamino-6-methoxyquinolin-4-yl)propyl]-!- [2- (3,4,5-trifluoro-phenoxy)ethyl]piperid-4-ylmethanol 4- [3- (3-Dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [3- (2,4,6-trifluorophenyl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(3-Dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[3- (3,4,5-trifluorophenyl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[3- (3,4,5-trifluoro-phenyl)propyl]piperid-4-ylmethanol 4- [3- (3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (2, 4, 6-trif luorophenyl-thio)ethyl]piperid-4-ylmethanol 4-[3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[2- (3, 4, 5-trifluorophenyl-thio)ethyl]piperid-4-ylmethanol 4-[3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[2- (2,4,6-trifluorophenyl-amino)ethyl]piperid-4-ylmethanol 4-[3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[2- (3,4, 5-trif luorophenyl-amino) ethyl] piper id-4-ylmethanol 4-[3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[2- (2,4,6-trifluorophenoxy)-ethyl]piperid-4-ylmethanol 4-[3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[2- (3,4,5-trifluorophenoxy)-ethyl]piperid-4-ylmethanol 4- [3- (3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (2,4,6-trifluorophenyl)prop-2-ynyl]piperid-4-ylmethanol 4- [3- (3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (3, 4, 5-trif luorophenyl)prop-2-ynyl]piperid-4-ylmethanol 4- [3- (3-Fluoroinethyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (2,4,6-trifluorophenyl)propyl]piperid-4-ylmethanol 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[3- (3,4,5-trifluorophenyl)propyl]piperid-4-ylmethanol 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2- (2,4,6-trifluorophenyl-thio)ethyl]piperid-4-ylmethanol 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2- (3,4,5-trifluorophenyl-thio)ethyl]piperid-4-ylmethanol 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2- (2,4,6-trifluorophenyl-amino)ethyl]piperid-4-ylmethanol 4- [3- (3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (3, 4, 5-trifluorophenyl-amino)ethyl]piperid-4-ylmethanol 4- [3- (3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,4, 6-trif luorophenoxy) -ethyl]piperid-4-ylmethanol 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2- (3,4, 5-trifluorophenoxy) -ethyl]piperid-4-ylmethanol 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[3- (2,4,6-trifluorophenyl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[3- (3,4,5-trifluorophenyl)prop-2-ynyl]piperid-4-ylmethanol 4- [3- (3-Aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (2,4, 6-trif luorophenyl) -propyl] piperid-4-ylmethanol 4- [3- (3-Aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (3,4, 5-trif luorophenyl) -propyl] piperid-4-ylmethanol 4- [3- (3-Aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,4,6-trifluorophenylthio)-ethyl]piperid-4-ylmethanol 4-[3-(3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2- (3,4,5-trifluorophenylthio)-ethyl]piperid-4-ylmethanol 4- [3- (3-Aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,4, 6-trif luorophenyl-amino) ethyl] piperid-4-ylmethanol 4- [3- (3-Aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (3,4, 5-trif luorophenylamino) -ethyl] piperid-4-ylmethanol 4- [3- (3-Aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,4, 6-trif luorophenoxy) -ethyl] piperid-4-ylmethanol 4-[3-(3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2- (3,4,5-trifluorophenoxy)-ethyl]piperid-4-ylmethanol 4- [3- (3-Aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [3-(2,4, 6-trifluorophenyl)prop-2-ynyl]piperid-4-ylmethanol 4- [3- {3-Aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [3-(3,4, 5-trif luorophenyl)prop-2-ynyl]piperid-4-ylmethanol 4- [3- (3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1-[3-(2,4,6-trifluorophenyl)-propyl]piperid-4-ylmethanol 4- [3- (3-Morpliolinomethyl-6-methoxyquinolin-4-yl)propyl] -1-[3-(3,4,5-trifluorophenyl)-propyl]piperid-4-ylmethanol 4- [3- (3-Morpholinornethyl-6-methoxyquinolin-4-yl)propyl] -1-[2- (2,4, 6-trifluorophenylthio) -ethyl]piperid-4-ylmethanol 4- [3- (3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1-[2-(3,4,5-trifluorophenylthio)-ethyl]piperid-4-ylmethanol 4-[3-(3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenyl-amino)ethyl]piperid-4-ylmethanol 4- [3- (3-Morpholinoxnethyl-6-methoxyquinolin-4-yl)propyl] -1-[2- (3, 4, 5-trifluorophenyl-amino)ethyl]piperid-4-ylmethanol 4- [3- (3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1-[2-(2,4,6-trifluorophenoxy)-ethyl]piperid-4-ylmethanol 4-[3-(3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenoxy)-ethyl]piperid-4-ylmethanol 4-[3-(3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)-prop-2-ynyl]piperid-4-ylmethanol 4-[3-(3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)-prop-2-ynyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-heptylpiperid-4-ylmethanol I-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- 1) propyl] -1- [4-phenylbutyl]piperid-4-ylmethanol 1- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- l)propyl] -1- [3- (phenyl)propyl] -piperid-4-ylmethanol 1- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- 1)propyl] -1- [4- (2-f luorophenyl)propyl]piperid-4-ylmethanol 1- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- l)propyl] -1- [4- (3-f luoroplienyl)propyl]piperid-4-ylmethanol i- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- 1)propyl] -1- [3- (4-fluoroplienyl) -propyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-cliloro-6-methoxyquinolin-4- l) propyl] -1- [4- (4-f luoroplienyl) -butyl] piperid-4-ylmethnol 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- y)ropyl]-1-[3-(2,3-difluorophenyl)-propyl]piperid-4- ylmethanol 4- [3- (R,S) -Hydroxy-3- (3-choro-6-methoxyquinolin-4- yl)propyl] -1- [4- (2, 3-dif luorophenyl) -propyl ]piperid-4- ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,6-difluorophenyl)-propyl]piperid-4- ylmethanol 4-[3-(R,S)-Hydroxy-3-{3-chloro-6-methoxyquinolin-4- yl)propyl]-!-[4-(2,6-difluorophenyl)-propyl]piperid-4- ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(3,5-difluorophenyl)-propyl]piperid-4- ylmethanol 4- [3- (R, S) -Hyc3roxy-3- (3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [3- (2,3, 5-trifluorophenyl)propyl]piperid-4- ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [3-phenylthio-propyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-inethoxyquinolin-4- yl)propyl]-l-[3-(2-fluorophenyl-thio)propyl]piperid-4- ylmethanol 4-[3-(R,S)-Hydroxy-3-{3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [3- (3-f luorophenyl-thio)propyl]piperid-4- ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yl) propyl] -1- [2- (4-fluorophenyl-thio) ethyl]piperid-4- ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [3- (4-fluorophenyl-thio) propyl]piperid-4- ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,3-difluorophenyl-thio)ethyl]piperid-4- ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [3- (2, 3-dif luorophenyl-thio)propyl]piperid-4- ylmethanol 4- [3- (R, S)-Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[2-(2,6-difluorophenyl-thio)ethyl]piperid-4- ylmethanol 4- [3- (R/S) -Hydroxy-3- (3-chloro-6-inethoxyquinolin-4-yl)propyl]-!-[2-(2,3,5-trifluorophenylthio)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl) propyl]-!- [2- (2,4, 6-trifluorophenylthio) ethyl ]piperid-4-ylmethano! 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yDpropyl] -!- [2- (3,4, 5-trif luorophenylttiio) ethyl ] piper id-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-inethoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluoro-phenoxy)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluoro-phenoxy)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluoro-phenoxy)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-!-[2-(3,4,5-trifluoro-phenoxy)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluoro-phenylamino)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,3,5-trifluoro-phenylamino)ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3'- (3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,4,6-trifluoro-phenylamino)ethyl]piperid- 4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,4,5-trifluoro-phenylamino)ethyl]piperid- 4-ylmethanol 4-[3-(R,S)-Hydroxy-3-{3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,6-difluoro-phenylthio)propyl]piperid-4- ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(2-chloro-phenylthio)ethyl]piperid-4- ylmethanol 4- [3- (R, S)-Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [3- (2-chloro-phenylthio)propyl]piperid-4- ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(3-chloro-phenylthio)ethyl]piperid-4- ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[3-(3-chloro-phenylthio)propyl]piperid-4- ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(4-chloro-phenylthio)ethyl]piperid-4- ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-!-[3-(4-chloro-phenylthio)propyl]piperid-4- ylmethanol 4- [3- (R, S) -Hydroxy-3- {3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [2- (2-methylphenyl-thio) ethyl ] piper id-4- ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yl) propyl] -1- [3- (2-methylphenyl-thio)propyl]piperid-4- ylmethanol 4- [3- (R, S) -Hydroxy-3- {3-chloro-6-methoxyquinolin-4- yl) propyl]-!- [2- (3-methylphenyl-thio) ethyl]piper id-4- ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [3- (3-methylphenyl-thio)propyl]piperid-4- ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yl) propyl] -1- [2- {4-methylphenyl-thio) ethyl] piperid-4- ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(4-methylphenyl-thio)propyl]piperid-4- ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [2- (2-trif luoromethyl-phenylthio)ethyl]piperid- 4-ylmethanol 4-[3-(R,S)-Hydroxy-3-{3-chloro-6-methoxyquinolin-4- yl)propyl]-!-[3-(2-trifluoromethy!- phenylthio)propyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -!- [2- (3-trif luoromethyl-phenylthio) ethyl]piperid- 4-ylmethanol 4- [3- (R, S) -Hydroxy-3- {3-chloro-6-methoxyquinolin-4-yl)propyl]-!-[3-(3-trifluoromethyl-phenylthio ) propyl ] piperid-4-ylinethanol 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-l-[2-(4-trifluoromethyl-phenylthio)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(4-trifluoromethyl-phenylthio)propyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2-methoxyphenyl-thio)ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- {3-chloro-6-methoxyquinolin-4-yDpropyl] -1- [3- {2-methoxyphenyl-thio)propyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [2- (3-methoxyphenyl-thio) ethyl]piper id-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yDpropyl] -1- [3- (3-methoxyphenyl-thio)propyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl)propyl]-l- [2- (4-methoxyphenyl-thio)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-{3-chloro-6-methoxyquinolin-4-yl)propyl]-!-[3-(4-methoxyphenyl-thio)propyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [cyclopentylmethyl] -piperid-4-yhnethanol 4-[3-{R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-!-[2-(cyclopentyl)ethyl]-piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [2- (cyclohexyl)ethyl] -piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- {3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [2- (cyclopentylthio) ethyl]piperid-4-ylmethanol 4- [3- (R,S) -Hydroxy-3- {3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [3- (cyclopentylthio) -propyl]piperid-4- ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[3-(cyclohexylthio)propyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(pyrid-2-yl)thioethyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[4-(thien-2-yl)butyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-l- [3- (thien-2-yl) thiopropyl]piperid-4-ylmethanol 4- [3- (R,S)-Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [3- (thien-3-yl)propyl]piperid-4-ylinethanol 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [4- (thien-3-yl)butyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [2- (thien-2-yl) thioethyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- {3-chloro-6-methoxyquinolin-4- yl)propyl]-l- [3- (thien-3-yl) thiopropyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-{3-chloro-6-methoxyquinolin-4-yl)propyl]-l-[3-(1,3-thiazol-2-yl)propyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yDpropyl] -1- [4- (1, 3-thiazol-2-yl)butyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-!-[3-(1,3-thiazol-2-yl)thioethyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(pyrid-2-yl)propyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[4-(pyrid-2-yl)butyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yDpropyl] -1- [3- {pyrid-2-yl) thiopropyl] piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (pyrid-3-yl)propyl]piperid-4-ylmethanol 4- [3- (R,S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [4- (pyrid-3-yl)butyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yDpropyl] -1- [2- {pyrid-3-yl) thioethyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (pyrid-3-yl) thiopropyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) propyl] -1- [3- {pyrid-4-yl) propyl] piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[4-(pyrid-4-yl)butyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- {3-chloro-6-methoxyquinolin-4- yl)propyl]-!-[2-{pyrid-4-yl)thioethyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [3- {pyrid-4-yl) thiopropyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-{3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[3-{pyrazin-2-yl)propyl]piperid-4-ylraethanol 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[4-(pyra2in-2-yl)butyl]piperid-4-ylinethanol 4- [3- {R, S) -Hydroxy-3- {3-chloro-6-xnethoxyquinolin-4- yl)propyl] -1- [2- (pyrazin-2-yl) thioethyl]piperid-4-yhnethanol 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yl) propyl] -1- [3- (pyrazin-2-yl) thiopropyl]piperid-4- ylmethanol 4- [3- (R,S) -Hydroxy-3- {3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(4-fluorophenyl)prop-2-ynyl]piperid-4- ylmethanol 4- [3- (R, S) -Hydroxy-3- {3-chloro-6-methoxyquinolin-4- yl)propyl]-!- [3- (3,4-difluorophenyl)prop-2-ynyl]piperid-4- ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-inetlioxyquinolin-4- yl)propyl]-1-[3-(2,4-difluorophenyl)prop-2-ynyl]piperid-4- ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]piperid- 4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]piperid-4 -ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yDpropyl] -1- [3- (3,4, 5-trif luorophenyl)prop-2-ynyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (4-chloro-3-f luoroplienyl)prop-2-ynyl ] piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (3-chloro-4-f luorophenyl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (2-chloro-4-f luorop]lenyl)prop-2-ynyl] piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1- [3- (3-chloro-5-f luorophenyl)prop-2-ynyl ] piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl)propyl]-1- [3- (4-chloro-2-f luorophenyl)prop-2-ynyl] piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-chloro-5-metlioxyquinolin-4-yl)propyl]-1-[3-(3-fluoro-4-methylphenyl)prop-2-ynyl] piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-xnethoxyquinolin-4-yDpropyl] -1- [3- (3, 5-bis (trifluoromethyl)phenyl)prop-2-ynyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- {3-chloro-6-methoxyquouin-4-yl)propyl]-!- [3- {thien-2-yl)prop-2-ynyl]piperid-4-ylmethanol 4- [3- (R,S)-Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (thien-3-yl)prop-2-ynyl]piperid-4-ylmethanol 4- [3- (R,S)-Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yDpropyl] -1- [3- (1, 3-thiazol-2-yl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(1,3-thiazol-4-yl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-{3-chloro-6-methoxyquinolin-4-yDpropyl] -1- [3- (1, 3-thiazol-5-yl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-l-[3-(pyrid-2-yl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-{3-chloro-6-methoxyquinolin-4-yl)propyl]-l-[3-(pyrid-3-yl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-{R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yDpropyl] -1- [3- {pyrid-4-yl)prop-2-ynyl]piperid-4-ylmethanol 4- [3- {R,S) -Hydroxy-3- (3-methyl-6-methoxyquinolin-4-yDpropyl] -1- [2- (cyclohexyl)ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-methyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (phenyl)propyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-{3-methyl-6-methoxyquinolin-4-3 yl)propyl]-l-[3-(2,3,5-trifluorophenyl)propyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-methyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,5-difluorophenylamino)ethyl]piperid-4- ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-methyl-6-methoxyquinolin-4- yDpropyl] -1- [2- (2,3, 5-trif luorophenylamino) ethyl]piperid-4- ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-methyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,5-difluorophenoxy)ethyl]piperid-4- ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-methyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,3,5-trifluorophenoxy)ethyl]piperid-4- ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-methyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,3,5-trifluorophenylthio)ethyl]piperid-4- ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-methyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(cyclopentylthio)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-methyl-6-methoxyquinolin-4- yDpropyl] -1- [2- (pyrid-2-yl) thioethyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-methyl-6-methoxyguinolin-4- yl)propyl] -1- [2- (thien-2-yl) thioethyl]piperid'-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-methyl-6-methoxyquinolin-4- yl)propyl]-!-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]piperid- 4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-methyl-6-methoxyquinolin-4- yl)propyl]-1-[3-(thien-2-yl)prop-2-ynyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-f luoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(cyclohexyl)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[3-(phenyl)propyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl] -1- [3-(2,3,5-trifluorophenyl)propyl]piperid-4-ylmethanol 4- [3- (R,S) -Hydroxy-3- (3-fluoro-6-methoxyquinolin-4-yl)propyl]-!-[2-(3,S-difluorophenylamino)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenylamino)ethyl]piperid-4-ylmethanol 4- [3- (R,S) -Hydroxy-3- (3-fluoro-6-methoxyquinolin-4-yl)propyl]-!-[2-(3,5-difluorophenoxy)ethyl]piperid-4-ylmethanol 4- [3- (R; S) ~Hydroxy-3- (3-f luoro-6-methoxyquinolin-4-yDpropyl] -!- [2- (2,3, 5-trifluorophenoxy)ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-f luoro-6-methoxyquinolin-4-yl)propyl]-!-[2-(2,3,S-trifluorophenylthio)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-!-[2-(cyclopentylthio)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yDpropyl] -1- [2- (pyrid-2-yl) thioethyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-fluoro-5-methoxyquinolin-4-yl)propyl] -1- [2- {thien-2-yl) thioethyl]piperid-4-ylinethanol 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-f luoro-6-metlioxyquinolin-4-yl)propyl]-!-[3-(thien-2-yl)prop-2-ynyl]piperid-4-ylinethanol 4- [3- (R, S) -Hydroxy-3- (3-dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [2- (cycloliexyl) ethyl] piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [3- (plienyl)propyl]piperid-4-ylmet]ianol 4- [3- (R, S) -Hydroxy-3- (3-dimethylamino-6-inethoxyquinolin-4-yl)propyl]-l-[3- (2,3, 5-trif luorophenyl)propyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluorophenylamino)ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-dimethylamino-5-methoxyquinolin-4-yl)propyl]-1- [2-(2,3,5-trifluorophenylamino)ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-l-[2-(3,5-difluorophenoxy)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenoxy)ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenylthio)ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[2-(cyclopentylthio)ethyl]piperid-4-yhnethanol 4- [3- (R, S) -Hydroxy-3- (3-dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [2- (pyrid-2-yl) thioethyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [2- (thien-2-yl) thioethyl]piperid-4-ylmetlianol 4- [3- (R, S) -Hydroxy-3- (3-dimet]iylainino-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[3-(thien-2-yl)prop-2-ynyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-]iydroxymethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (cyclohexyl)et]iyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-liydroxymethyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (phenyl)propyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-!-[3-(2,3,5-trifluoroplienyl)propyl]piperid-4-ylmethanol 4- [5- (R, S) -Hydroxy-3- (3-hydroxymethyl-6-metlioxyquinolin-4-yl) propyl]-!- [2- (3, 5-dif luorophenylamino) ethyl]piperid-4-y]methanol 4- [3- (R, S) -Hydroxy-3- (3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-!-[2-(2,3,5-trifluorophenylamino)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-hydroxymethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,5-difluorophenoxy)ethyl]piperid-4- ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-hydroxymethyl-6-methoxyquinolin-4- yDpropyl] -1- [2- (2,3, 5-trif luorophenoxy) ethyl]piperid-4- ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-hydroxyinethyl-6-methoxyquinolin-4- yl)propyl]-l-[2-(2,3,5-trifluorophenylthio)ethyl]piperid-4- ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-hydroxymethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(cyclopentylthio)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-hydroxymethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(pyrid-2-yl)thioethyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-hydroxymethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(thien-2-yl)thioethyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-hydroxymethyl-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]piperid- 4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-hydroxymethyl-6-methoxyquinolin-4- yl)propyl]-1-[3-(thien-2-yl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(cyclohexyl)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyguinolin-4- yl)propyl]-1-[3-(phenyl)propyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,3,5-trifluorophenyl)propyl]piperid-4- ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-f luoromethyl-6-methoxyquinolin-4-yl)propyl]-l- [2- (3, 5-difluorophenylarnino) ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-f luoromethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,3, 5-trifluorophenylamino) ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-fluoroxnethyl-6-methoxyquinolin-4-yl)propyl]-l-[2-(3,5-difluorophenoxy)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-{3-fluorornethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenoxy)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,3,5-trifluorophenylthio)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-inethoxyquinolin-4-yl)propyl]-1-[2-(cyclopentylthio)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(pyrid-2-yl)thioethyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl] -1- [2-(thien-2-yl)thioethyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(thien-2-yl)prop-2-ynyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4- yl)propyl] -1- [2- (cyclohexyl) ethyl]piperid-4-ylinethanol 4- [3- (R, S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4- yl) propyl ] -1- [ 3 - (phenyl) propyl ] piperid-4-ylmethanol 4- [3- (R,S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4- yl)propyl]-l-[3-(2,3,5-trifluorophenyl)propyl]piperid-4- ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4- yl)propyl]-l-[2-(3,5-difluorophenylamino)ethyl]piperid-4- ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,3,5-trifluorophenylamino)ethyl]piperid-4- ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-aininomethyl-6-methoxyquinolin-4- yl) propyl]-!- [2- (3, 5-dif luorophenoxy) ethyl] piper id-4- ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4- yl)propyl]-l-[2-(2,3,5-trifluorophenoxy)ethyl]piperid-4- ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-aininomethyl-6-methoxyquinolin-4- yl)propyl]-l- [2- (2,3, 5-trif luorophenyl thio) ethyl ]piperid-4- ylmethanol 4- [3- (R,S)-Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4- yl)propyl] -1- [2- (cyclopentylthio) ethyl] piper id-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4- yDpropyl] -1- [2- (pyrid-2-yl) thioethyl]piperid-4-ylinethanol 4- [3- (R, S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (thien-2-yl) thioethyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]piperid-4-ylmethanol 4- [3- (R,S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4-yl) propyl] -1- [3- (t]iien-2-yl)prop-2-ynyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (cyclohexyl) ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (phenyl)propyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- O-moirpholinometlnyl-e-methoxyquinolin-4-yl) propyl] -1- [3- (2 , 3, 5-trif luorophenyl) propyl] piper id-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-morpholinornethyl-6-methoxyquinolin-4-yl)propyl] -1-[2-(3,5-difluorophenylamino)ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- {3-inorpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (2, 3, 5-trif luorophenylamino)etliyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (3, 5-dif luorophenoxy) ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-inorp]iolinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,3, 5-trif luorophenoxy) etliyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxyquinolin-4-y 1)propyl]-l- [2- (2,3, 5-trifluorophenylthio) ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (cyclopentylthio)ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydro:>o/-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (pyrid-2-yl) thioethyl]piperid-4-ylTnethanol 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (thien-2-yl) thioethyl]piperid-4-ylraethanol 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (2,3, 5-trif luorophenyl)prop-2-ynyl] piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (thien-2-yl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-methyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)propyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-methyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)propyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenylthio)ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-methyl-6-niethoxyquinolin-4-yDpropyl] -1- [2- (3,4, 5-trifluorophenylthio)ethyl]piperid-4-ylmethanol 4- [3- (R, S)-Hydroxy-3- (3-methyl-6-methoxyquinolin-4-yl)propyl]-!-[2-(2,4,6-trifluorophenylaInino)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenylainino)ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-methyl-6-methoxyquinolin-4-yDpropyl] -1- [2- (2,4, 6-trif luorophenoxy) ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-methyl-6-methoxyquinolin~4-yDpropyl] -1- [2- (3, 4, 5-trif luorophenoxy)ethyl]piperid-4~ ylmethanol 4- [3- (R,S)-Hydroxy-3- (3-methyl-6-methoxyquinolin-4-yl)propyl]-l-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-methyl-6-methoxyquinolin-4-yl)propyl]-l-[3-(3,4,5-trifluorophenyl)prop-2-ynyl]piperid-4-ylinethanol 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-!-[3-(2,4,6-trifluorophenyl)propyl]piperid-4-ylmethanol 4-[3-(R/S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)propyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenylthio)ethyl]piperid-4-ylmethanol 4-[3-{R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yDpropyl] -1- [2- (3, 4, 5-trifluorophenylthio)ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-f luoro-6-methoxyquinolin-4-yl)propyl]-1- [2- (2,4, 6-trif luorop]ienylainino)ethyl]piperid-4-ylmethanol 4- [3- (R,S)-Hydroxy-3-(3-fluoro-6-methoxyguinolin-4-yDpropyl] -1- [2- (3,4, 5-trif luorophenylamino) ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-f luoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenoxy)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl] -1- [2- (3,4,5-trifluorophenoxy)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluoropheny1)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-l-[3-(3,4,5-trifluoropheny1)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [3- (2,4, 6-trifluorophenyl)propyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-dimethylamino-6-methoxyquinolin-4- yl)propyl] -1- [3- (3,4, 5-trifluorophenyl)propyl]piperid-4- ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-dirnethylamino-6-methoxyquinolin-4- yl)propyl]-!- [2- (2, 4, 6-trifluorophenylthio)ethyl]piperid-4- ylmethanol 4- [3- (R,S) -Hydroxy-3- (3-dimethylaxnino-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,4,5-trifluorophenylthio)ethyl]piperid-4- ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-dimethylamino-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,4,6-trifluorophenylamino)ethyl]piperid-4- ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-dimethylamino-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,4,5-trifluorophenylamnino)ethyl]piperid-4- ylmethanol 4- [3- (R,S) -Hydroxy-3- (3-dimethylamino-6-methoxyquinolin-4- yl)propyl] -1- [2- (2,4, 6-trifluorophenoxy) ethyl]piperid-4- ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-dimethylamino-6-methoxyquinolin-4- yDpropyl] -1- [2- (3,4, 5-trifluorophenoxy)ethyl]piperid-4- ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-dimethylamino-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]piperid- 4-ylmethanol 4- [3- (R,S) -Hydroxy-3- (3-dimethylamino-6-methoxyquinolin-4- yl)propyl]-!-[3-(3,4,5-trifluorophenyl)prop-2-ynyl]piperid- 4-ylmethanol 4- [3- (R, S) -Hydroxy-3- {3-hydroxymethyl-6-methoxyquinolin-4- yl)propyl]-1-[3-(3,4,5-trifluorophenyl)propyl]piperid-4- ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-hydroxymethyl-6-methoxyquinolin-4- yl)propyl] -1- [2- (2,4, 6-trif luorophenylthio)etliyl]piperid-4- ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-hydroxyTnethyl-6-inet]ioxyquinolin-4- yl)propyl] -1- [2- (3, 4, 5-trifluorophenyltliio) ethyl]piperid-4- ylmetiianol 4- [3- (R, S) -Hydroxy-3- (3-]iydroxymethyl-6-methoxyquinolin-4- yl)propyl] -1- [2- (2, 4, 6-trifluorophenylamino) ethyl]piperid-4- ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-hydroxymethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,4,5-trifluorophenylamino)etliyl]piperid-4- ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-hydroxymethyl-6-methoxyquinolin-4- yl) propyl ]-l- [2- (2,4, 6-trif luorophenoxy) ethyl] piper id-4- ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-hydroxymethyl-6-methoxyquinolin-4- yDpropyl] -1- [2- (3, 4, 5-trif luorophenoxy)ethyl]piperid-4- ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-hydroxymethyl-6-methoxyquinolin-4- yDpropyl] -1- [3- (2,4, 6-trif luorophenyl)prop-2-ynyl]piperid- 4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-hydroxymethyl-6-methoxyquinolin-4- yDpropyl] -1- [3- (3,4, 5-trif luorophenyl )prop-2-ynyl] piperid- 4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)propyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)propyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-{3-fluoromethyl-6-methoxyquinolin-4-yl) propyl] -1- [2- (2,4, 6-trif luorophenylthio) ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-f luoromet]lyl-6-met]loxyquinolin-4-yl)propyl] -1- [2- (3, 4, 5-trif luorophenyl thio) ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-f luoroInet]lyl-6-I-etlloxyquinolin-4-yl)propyl] -1- [2- (2, 4, 6-trif luorophenylamino)ethyl] piper id-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-f luoromethyl-6-methoxyquinolin-4-yl)propyl]-!-[2-(3,4,5-trifluorophenylamino)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-!-[2-(2,4,6-trifluorophenoxy)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenoxy)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yDpropyl] -1- [3- (2,4, 6-trif luorophenyl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4~ yl)propyl] -1- [3-(3,4,5-trifluorophenyl)prop-2-ynyl]piperid 4-ylmethanol 4- [3- (R,S) -Hydroxy-3- (3-aminomethyl-6-n\ethoxyquinolin-4-yDpropyl] -1- [3- (2,4, 6-trif luorophenyl)propyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4-yDpropyl] -1- [3- (3, 4, 5-trif luorophenyl)propyl]piperid-4-ylI-ethanol 4- [3- (R,S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4-yDpropyl] -1- [2- {2, 4, 6-trif luorophenylthio) ethyl] piper id-4 ylmethanol 4- [3- (R,S) -Hydroxy-3- {3-aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (3, 4, 5-trif luorophenylthio)et]n.yl]piperid- 4 ylmethanol 4- [3- (R,S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,4, 6-trif luorophenylamino) ethyl] piper id 1 ylmethanol 4- [3- (R,S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4-yDpropyl] -1- [2- (3,4, 5-trif luorophenylamino) ethyl]piperid 4 ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4-yDpropyl] -1- [2- (2,4, 6-trif luorophenoxy) ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4 yDpropyl] -1- [2- (3, 4, 5-trif luorophenoxy)ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]piperici 4-ylinethanol 4- [3- (R, S) -Hydroxy-3- (3-aminomethyl-6~methoxyquinolin-4- yl)propyl]-l-[3-(3,4,5-trifluorophenyl)prop-2-ynyl]piperid 4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-inorpholinomethyl-6-methoxyquinolin 4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)propyl]piperid-4- ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-morpholinomethyl-6-methoxyquinolin 4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)propyl]piperid-4- ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-inorpholinomethyl-6-methoxyquinolin 4-yl)propyl] -1- [2- (2, 4, 6-trif luorophenylthio) ethyl]piperid 4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxyquinolin 4-yl)propyl] -1- [2- (3, 4, 5-trif luorophenylthio) ethyl] piper id 4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxyquinolin 4-yl)propyl]-1-[2-(2,4,6-trifluorophenylamino)ethyl]piperid 4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-morpholinomethyl-6-methoxyquinolin 4-yl)propyl]-l-[2-(3,4,5-trifluorophenylamino)ethyl]piperid 4-ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxyquinolin 4-yl)propyl]-l-[2-(2,4,6-trifluorophenoxy)ethyl]piperid-4- ylmethanol 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenoxy)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)prop-2-ynyl] piperid-4-ylmethanol 4-[3-(R,S)-Hydroxy-3-(3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)prop-2-ynyl] piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl) propyl ] -l-heptylpiperid-4-ylmethanol 4-[3-(R, S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl) propyl] -1- [4-phenylbutyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl) propyl] -1- [3- (phenyl)propyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[4-(2-fluorophenyl)propyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- {3-chloro-6-methoxyc[uinolin-4-yl) propyl] -1- [4- (3-f luorophenyl) propyl] piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-chloro-6-inetlaoxyquinolin-4-yl) propyl] -1- [3- (4-fluorophenyl)propyl]piperid-4-ylinethanol 4- [3- (R,S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) propyl] -1- [4- (4-f luorophenyl)butyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3-difluorophenyl)propyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[4-(2,3-difluorophenyl)propyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,6-difluorophenyl)propyl]piperid-4- ylmethanol 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[4-(2,6-difluorophenyl)propyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(3,5-difluorophenyl)propyl]piperid-4- ylmethanol 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl) propyl] -1- [3- (2, 3, 5-trif luorophenyl) propyl] piper id-4- ylmethanol 4- [3- (R,S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,4,6-trifluorophenyl)propyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(3,4,5-trifluorophenyl)propyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-phenylthio-propyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(2-fluorophenylthio)propyl]piperid-4- ylmethanol 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(3-fluorophenylthio)propyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [2- {4-f luorophenylthio) ethyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-{4-fluorophenylthio)propyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,3-difluorophenylthio)ethyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-xnethoxyquinolin-4- yl)propyl]-!-[3-(2,3-difluorophenylthio)propyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[2-(2,6-difluorophenylthio)ethyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[2-(2,3,5-trifluorophenylthio)ethyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-!-[2-(2,4,6-trifluorophenylthio)ethyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-ch!oro-6-methoxyquinolin-4- yl)propyl]-!-[2-(3,4,5-trifluorophenylthio)ethyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluorophenoxy)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [2- (2, 3, 5-trifluorophenoxy) ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl) propyl] -1- [2- (2,4, 6-trifluorophenoxy) etllyl]piperid-4-ylmetllanol 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [2- (3, 4, 5-trif luoropllenoxy)et]lyl]piperid-4-yl-let}lanol 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluorophenylamino)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenylamino)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenylamino)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-!-[2-(3,4,5-trifluorophenylamino)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,6-difluorophenylthio)propyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[2-(2-chlorophenylthio)ethyl]piperid-4- ylmethanol 4-[3-{R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [3- {2-chlorophenylthio)propyl]piperid-4- ylmethanol 4- [3- (R, S) -Fluoro-3- {3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(3-chlorophenylthio)ethyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(3-chlorophenylthio)propyl]piperid-4- ylinethanol 4-[3-(R, S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(4-chlorophenylthio)ethyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(4-chlorophenylthio)propyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-{2-methylphenylthio)ethyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(2-methylphenylthio)propyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [2- (3-methylphenylthio) ethyl]piperid-4- ylmethanol 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [3- (3-methylphenylthio)propyl]piperid-4- ylmethanol 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [2- (4-methylphenylthio) ethyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(4-methylphenylthio)propyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [2- (2-trif luoromethylphenylthio) ethyl]piperid- 4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-{2-trifluoromethylphenylthio)propyl]piperid- 4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [2- (3-trif luoromethylphenylthio) ethyl]piperid- 4-ylmethanol 4- [3- (R,S)-Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-{3-trifluoromethyIphenylthio)propyl]piperid- 4-ylinethanol 4-[3-{R,S)-Fluoro-3-{3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-{4-trifluoromethylphenylthio)ethyl]piperid- 4-ylmethanol 4-[3-{R,S)-Fluoro-3-{3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-{4-trifluoromethylphenylthio)propyl]piperid- 4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-l-[2-(2-methoxyphenylthio)ethyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [3- (2-methoxyphenylthio)propyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [2- {3-methoxyphenylthio) ethyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-{3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [3- {3-methoxyphenylthio)propyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(4-methoxyphenylthio)ethyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [3- (4-methoxyphenylthio)propyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [cyclopentylmethyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(cyclopentyl)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [2- (cyclohexyl) -ethyl] piper id-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(cyclopentylthio)-ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(cyclopentylthio)-propyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(cyclohexylthio)-propyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl) propyl] -1- [2- (pyrid-2-yl) thioethyl] -piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl) propyl] -1- [4- (thien-2-yl)butyl] -piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-{3-chloro-6-methoxyquinolin-4- yl) propyl] -1- [3- (thien-2-yl) thiopropyl] -piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl) propyl] -1- [3- {thien-3-yl)propyl]-piperid-4-ylmethanol 4- [3- (R,S)-Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [4- (thien-3-yl)butyl] -piperid-4-ylmethanol 4- [3- (R,S)-Fluoro-3- (3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [2- (thien-2-yl) thioethyl] -piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [2- (thien-3-yl) thioethyl] -piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- {3-chloro-6-metgoxyquinolin-4- yl) propyl] -1- [3- (thien-3-yl) thiopropyl] -piperid-4-ylmethanol 4- [3- (R,S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl) propyl] -1- [3- (1, 3-thiazol-2-yl)propyl]piperid-4- ylmethanol 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [4- (1, 3-thiazol-2-yl)butyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(1,3-thiazol-2-yl)thioethyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(pyrid-2-yl)propyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[4-(pyrid-2-yl)butyl]piperid-4-ylinethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(pyrid-2-yl)thiopropyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(pyrid-3-yl)propyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[4-(pyrid-3-yl)butyl]piperid-4-ylinethanol 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[2-(pyrid-3-yl)thioethyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [3- (pyrid-3-yl) thiopropyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl) propyl] -1- [3- (pyrid-4-yl)propyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl) propyl] -1- [4- (pyrid-4-yl)butyl]piperid-4-yhnethanol 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl) propyl] -1- [2- (pyrid-4-yl) thioethyl]piperid-4-ylinethanol 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl) propyl] -1- [3- (pyrid-4-yl) thiopropyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4- 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[4-(pyrazin-2-yl)butyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(pyrazin-2-yl)thioethyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-{pyrazin-2-yl)thiopropyl]piperid-4-ylmethanol 4-[3-(R/S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(4-fluorophenyl)prop-2-ynyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4-difluorophenyl)prop-2-ynyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4-difluorophenyl)prop-2-ynyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (2, 3 , 5-trif luorophenyl)prop-2-ynyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl)propyl]-!-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]piperid-4 -y Imethanol 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yDpropyl] -1- [3- (3,4, 5-trif luorophenyl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(4-chloro-3-fluorophenyl)prop-2- ynyl] piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yDpropyl] -1- [3- {3-chloro-4-f luorophenyl)prop-2- ynyl] piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(2-chloro-4-fluorophenyl)prop-2- ynyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(3-chloro-5-fluorophenyl)prop-2- ynyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(4-chloro-2-fluorophenyl)prop-2- ynyl ] piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [3- (3-fluoro-4-methylphenyl)prop-2- ynyl ] piperid-4-ylinethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4- yl)propyl]-1-[3-(3,5-bis(trifluoromethyl)phenyl)prop-2- ynyl ] piperid-4-ylmethanol 4- [3- (R,S)-Fluoro-3- (3-chloro-6-methoxyquinolin-4- yl)propyl] -1- [3- (thien-2-yl)prop-2-ynyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-chloro-6-metlaoxyquinolin-4- y 1) propyl ] -1 - [ 3 - (thien- 3 -y 1) prop- 2 -yny 1 ] piper id- 4 -ylmethanol 4-[3-(R,S)-Fluoro-3-{3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(1,3-thiazol-2-yl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl) propyl] -1- [3- (1, 3-thiazol-4-yl)prop-2-ynyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- {3-chloro-6-methoxyquinolin-4-yDpropyl] -1- [3- (1, 3-thiazol-5-yl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yDpropyl] -1- [3- (pyrid-2-yl)prop-2-ynyl]piperid-4-ylmethanol 4- [3- (R,S)-Fluoro-3- (3-chloro-6-methoxyquinolin-4-yDpropyl] -1- [3- (pyrid-3-yl)prop-2-ynyl]piperid-4-ylmethanol 4- [3- (R,S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (pyrid-4-yl)prop-2-ynyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-methyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (cyclohexyl) ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(phenyl)propyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-methyl-6-methoxyquinolin-4-yDpropyl] -1- [3- (2,3, 5-trifluorophenyl)propyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-methyl-6-methoxyquinolin-4-yl)propyl]-!- [2- (3, 5-difluorophenylamino)et]ayl]piperid-4-yl-methnol 4- [3- (R, S) -Fluoro-3- (3-methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenylamino)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4-yDpropyl] -1- [2- (3, 5-dif luorophenoxy) ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenoxy)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenylthio)ethyl]piperid-4-ylmethanol 4- [3- (R,S)-Fluoro-3- (3-methyl-6-xnethoxyquinolin-4-yl)propyl] -1- [2- (cyclopentylthio) ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(pyrid-2-yl)thioethyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(thien-2-yl)thioethyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4-yl)propyl]-l-[3-(thien-2-yl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(eyelohexyl)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl] -1- [3-(phenyl)propyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)propyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluorophenylamino)ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-f luoro-6-methoxyquinolin-4-yl)propyl]-!- [2- (2,3, 5-trifluorophenylamno)ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-f luoro-6-methoxyquinolin-4-yl) propyl] -1- [2- (3, 5-dif luoroplienoxy) et]lyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-f luoro-6-methoxyquinolin-4-yl)propyl] -1- [2- (2, 3, 5-trif luoroplienoxy) ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-f luoro-6-methoxyquinolin-4-yl)propyl]-!- [2- (2, 3, 5-trifluoroplienyltliio)etllyl]piperid-4-ylmetllanol 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yDpropyl] -1- [2- (cyclopentylthio) ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl] -!- [2- (pyrid-2-yl) thioethyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-f luoro-6-methoxyquinolin-4-yDpropyl] -1- [2- (thien-2-yl) thioethyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yDpropyl] -!- [3- (2,3, 5-trifluorophenyl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl] -1- [3-(thien-2-yl)prop-2-ynyl]piperid-4-ylinethanol 4-[3-(R,S)-Fluoro-3-(3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[2-(eyelohexyl)ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-dimethylaiTiino-6-methoxyquinolin-4-yl) propyl] -1- [3- (phenyl)propyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-{3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)propyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [2- (3, 5-difluorophenylamino)ethyl]piperid-4-ylmethanol 4- [3- (R, S)-Fluoro-3- (3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenylamino)ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluorophenoxy)ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenoxy)ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenylthio)ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [2- (eyclopentylthio) ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-{3-dimethylamino-6-methoxyquinolin-4-yl)propyl] -1- [2- (pyrid-2-yl) thioethyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-dimethylamino-6-methoxyquinolin-4-yDpropyl] -1- [2- (thien-2-yl) thioethyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-{3-dimethylainino-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]piperid-4-ylinethanol 4- [3- (R, S) -Fluoro-3- (3-dimethylainino-6-methoxyquinolin-4-yl)propyl] -1- [3- (thien-2-yl)prop-2-ynyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(cyclohexyl)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-hydroxymethyl-6-methoxyquinolin-4-yl) propyl] -1- [3- (phenyl) propyl] piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-hydroxymethyl-6-methoxyquinolin-4-yl) propyl ]-l- [3- (2,3, 5-trif luorophenyl) propyl] piper id-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-tiydroxyTnethyl-6-methoxyquinolin-4-yl)propyl]-l- [2- (3, 5-dif luoropllenylamino)et]lyl]piperid-4-ylmethanol 4- [3- (R,S)-Fluoro-3- (3-laydroxymethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (2, 3, 5-trif luoroptienylamino) ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-hydroxymethyl-6-inethoxyquinolin-4-yl)propyl]-l- [2- (3, 5-dif luorophenoxy) ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Fl-uoro-3- (3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenoxy)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-hydroxymethyl-6-methoxyquinolin-4-yDpropyl] -1- [2- (2,3, 5-trif luorophenylthio) ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-hydroxymethyl-6-methoxyquinolin-4-yl) propyl] -1- [2- (cyclopentylthio) etliyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3-- (3-hyroxymethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- {pyrid-2-yl) thioethyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-hydroxymethyl-6-methoxyquinolin-4~ yl) propyl] -1- [2- (thien-2-yl) thioethyl] piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-l-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro -3- (3-]iydroxymethyl-6-methoxyquinolin-4-yl)propyl] -1- [3- {thien-2-yl)prop-2-ynyl]piperid-4'ylraethanol 4- [3- (R, S) -Fluoro-3- {3-f luoromethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (cyclohexyl) ethyl]piperid-4-ylmethanol 4-[3- (R, S)-Fluoro-3- (3-f luoroxmethyl-6-inethoxyquinolin-4-yl) propyl] -1- [3- (pheny 1) propyl] piper id-4-ylmethanol 4- [3- {R, S) -Fluoro-3- {3-f luoromethyl-6-methoxyq[uinolin-4-yl)propyl]-l-[3-(2,3,5-trifluoroplaenyl)propyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-f luoroInetllyl-6-methoxyquinolin-4-y1 )propyl]-l-[2-(3,5-difluorophenylamino)ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-f luoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenylamino)ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-f luoromethyl-6-methoxyquinolin-4-yDpropyl] -1- [2- (3, 5-difluorophenoxy)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl] -1-[2-(2,3,5-trifluorophenoxy)ethyl]piperid-4-ylmethanol 4- [3- (R,S)-Fluoro-3- (3-f luoromethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,3, 5-trif luorophenylthio) ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl] -1-[2-(cyclopentylthio)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (pyrid-2-yl) thioethyl]piperid-4-ylinethanol 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4-yDpropyl] -1- [2- (thien-2-yl) thioethyl]piperid-4-ylinethanol 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4-yDpropyl] -1- [3- (2,3, 5-trif luorophenyl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-l-[3-(thien-2-yl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-aminomethyl-6-methoxyquinolin-4-yDpropyl] -1- [2- (cyclohexyl)ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (phenyl)propyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-aminomethyl-6-methoxyquinolin-4- yDpropyl] -1- [3- (2,3, 5-trifluorophenyl)propyl]piperid-4- ylmethanol 4- [3- (R,S)-Fluoro-3- (3-aminomethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,5-difluorophenylamino)ethyl]piperid-4- ylmethanol 4- [3- (R, S) -Fluoro-3- (3-aminomethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,3,5-trifluorophenylamino)ethyl]piperid-4- ylmethanol 4- [3- (R, S) -Fluoro-3- (3-aininomethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,5-difluorophenoxy)ethyl]piperid-4- ylmethanol 4- [3- (R, S) -Fluoro-3- (3-aminomethyl-6-methoxyquinolin-4- yl)propyl]-l-[2-(2,3,5-trifluorophenoxy)ethyl]piperid-4- ylmethanol 4- [3- (R, S) -Fluoro-3- (3-aminomethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,3,5-trifluorophenylthio)ethyl]piperid-4- ylmethanol 4- [3- (R, S) -Fluoro-3- (3-aininomethyl-6-methoxyquinolin-4- yl)propyl]-l- [2- (cyclopentylthio)ethyl]piperid-4-ylinethanol 4- [3- (R, S) -Fluoro-3- (3-aminomethyl-6-methoxyguinolin-4- yl)propyl] -1- [2- (pyrid-2-yl) thioethyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-aminomethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(thien-2-yl)thioethyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-aminomethyl-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]piperid- 4-ylmethanol 4- [3- (R,S) -Fluoro-3- (3-aminomethyl-6-methoxyquinolin-4- yl)propyl] -1- [3- (thien-2-yl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(R, S)-Fluoro-3-(3-morpholinomethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(cyclohexyl)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-morpholinomethyl-6-methoxyquinolin-4- yl)propyl]-1-[3-(phenyl)propyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-morpholinomethyl-6-methoxyquinolin-4- yl) propyl] -1- [3- (2, 3 , 5-trif luorophenyl) propyl] piper id-4- ylmethanol 4- [3- (R, S) -Fluoro-3- (3-inorpholinomethyl-6-inetlioxyquinolin-4- yl)propyl]-!-[2-(3,5-difluorophenylamino)ethyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-inorpholinomethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,3,5-trifluorophenylamino)ethyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-morpholinomethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,5-difluorophenoxy)ethyl]piperid-4- ylmethanol 4- [3- (R, S) -Fluoro-3- (3-morpholinomethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,3,5-trifluorophenoxy)ethyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-morpholinomethyl-6-methoxyquinolin-4- yDpropyl] -1- [2- (2,3, 5-trif luorophenylthio)ethyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-morpholinomethyl-6-methoxyquinolin-4- yl)propyl]-l-[2-(cyclopentylthio)ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-morpholinomethyl-6-methoxyquinolin-4- yl)propyl] -1- [2- (pyrid-2-yl) thioethyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-morpholinomethyl-6-methoxyquinolin-4- yDpropyl] -1- [2- (thien-2-yl) thioethyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-morpholinomethyl-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]piperid- 4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-morpholinomethyl-6-methoxyquinolin-4- yl)propyl] -1- [3- (thien-2-yl)prop-2-ynyl]piperid-4-ylinethanol 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,4,6-trifluorophenyl)propyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4- yl)propyl]-!-[3-(3,4,5-trifluorophenyl)propyl]piperid-4- ylmethanol 4- [3- (R,S)-Fluoro-3- (3-methyl-6-methoxyquinolin-4- yl)propyl] -1- [2- (2, 4, 6-trif luorophenylthio) ethyl]piperid-4- ylmethanol 4- [3- (R, S) -Fluoro-3- (3-methyl-6-]methoxyquinolin-4- yl)propyl]-1-[2-(3,4,5-trifluorophenylthio)etliyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,4,6-trifluorophenylamino)ethy1]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,4,5-trifluorophenylamino)ethyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4- yDpropyl] -1- [2- (2,4, 6-trif luorophenoxy) ethyl]piperid-4- ylmethanol 4- [3- (R, S) -Fluoro-3- (3-methyl-6-methoxyquinolin-4- yl)propyl] -1- [2- (3, 4, 5-trif luorophenoxy) ethyl]piperid-4- ylmethanol 4- [3- (R, S) -Fluoro-3- (3-methyl-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]piperid- 4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4- yl)propyl]-1-[3-(3,4,5-trifluorophenyl)prop-2-ynyl]piperid- 4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,4,6-trifluorophenyl)propyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4- yl)propyl]-1-[3-(3,4,5-trifluorophenyl)propyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,4,6-trifluorophenylthio)ethyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,4,5-trifluorophenylthio)ethyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,4,6-trifluorophenylamino)ethyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4- yl)propyl]-l-[2-(3,4,5-trifluorophenylamino)ethyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-{3-fluoro-6-methoxyquinolin-4- yl)propyl]-!-[2-(2,4,6-trifluorophenoxy)ethyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-{3-fluoro-6-methoxyquinolin-4- yDpropyl] -1- [2- {3,4, 5-trif luorophenoxy) ethyl ] piper id-4- ylmethanol 4-[3-(R,S)-Fluoro-3-{3-fluoro-6-methoxyquinolin-4- yl)propyl]-!-[3-{2,4,6-trifluorophenyl)prop-2-ynyl]piperid- 4-ylmethanol 4-[3-{R,S)-Fluoro-3-{3-fluoro-6-methoxyquinolin-4- yl)propyl]-!-[3-{3,4,5-trifluorophenyl)prop-2-ynyl]piperid- 4-ylmethanol 4-[3-{R,S)-Fluoro-3-{3-dimethylamino-6-methoxyquinolin-4- yl)propyl]-!-[3-{2,4,6-trifluorophenyl)propyl]piperid-4- ylmethanol 4-[3-{R,S)-Fluoro-3-{3-dimethylamino-6-methoxyquinolin-4- yDpropyl]-!- [3- {3,4, 5-trif luorophenyl) propyl] piperid-4- ylmethanol 4- [3- {R, S) -Fluoro-3- {3-dimethylamino-6-methoxyquinolin-4- yl)propyl] -1- [2- {2, 4, 6-trif luorophenylthio) ethyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-{3-dimethylamino-6-methoxyquinolin-4- yl)propyl]-1-[2-{3,4,5-trifluorophenylthio)ethyl]piperid-4- ylmethanol 4- [3- (R, S) -Fluoro-3- {3-dimethylainino-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenylamino)ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenylamino)et]iyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-dimetliylamino-6-methoxyquinolin-4-yl)propyl]-!- [2- (2,4, 6-trifluorophenoxy)et]lyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenoxy)ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-dimethylaiTiino-6-methoxyquinolin-4-yl)propyl] -1- [3- (2,4, 6-trif luorophenyl)prop-2-ynyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-dimethylaitiino-6-methoxyquinolin-4-yDpropyl] -1- [3- (3, 4, 5-trif luorophenyl)prop-2-ynyl]piperid-4-y Ijnethano 1 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yDpropyl] -1- [3- (2,4, 6-trif luorophenyl)propyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-!-[3-(3,4,5-trifluorophenyl)propyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-hydroxymethyl-6-methoxyquinolin-4-yDpropyl] -1- [2- (2,4, 6-trif luorophenylthio)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-{3-hydroxymethyl-6-methoxyquinolin-4-yDpropyl] -1- [2- (3,4, 5-trifluorophenylthio) ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,4, 6-trifluorophenylamino) ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-hydroxymethyl-6-methoxyqainolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenylamino)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-hydroxymethyl-6-methoxyquinolin-4-yDpropyl] -1- [2- (2, 4, 6-trif luorophenoxy) ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-!-[2-(3,4,5-trifluorophenoxy)ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-hydroxyTnethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (2,4,6-trifluorophenyl)propyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4-yDpropyl] -1- [3- (3,4, 5-trif luorophenyl) propyl ]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-f luoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenylthio)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-l-[2-(3,4,5-trifluorophenylthio)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,4, 6-trif luorop]ienylainino)etliyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-fluoromet]lyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (3, 4, 5-trifluorop]ienylamino)etliyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-f luoromethyl-5-methoxyquinolin-4-yl)propyl] -1- [2- (2, 4, 6-trif luorophenoxy) et]lyl]piperid-4-ylmet]lanol 4- [3- (R, S) -Fluoro-3- (3-f luoromethyl-6-methoxyquinolin-4-yDpropyl] -1- [2- (3,4, 5-trifluorophenoxy)etliyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3"(3-fluoromethyl-6-met]loxyquinolin-4-yl)propyl] -1- [3- (2,4, 6-trifluorop]ienyl)prop-2-ynyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-f luoroinetliyl-6-inetlioxyquinolin-4-yl)propyl]-l-[3-(3,4,5-trifluorophenyl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-aminomethyl-6-methoxyquinolin-4-yDpropyl] -1- [3- (2,4, 6-trif luorophenyl)propyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-aininomethyl-6-methoxyquinolin-4- yl)propyl]-1-[3-(3,4,5-trifluorophenyl)propyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-aminomethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,4,6-trifluoroplaenylthio)ethyl]piperid-4- ylmethanol 4- [3- (R,S)-Fluoro-3- (3-aininomethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,4,5-trifluorop]ienylthio)ethyl]piperid-4- ylmethanol 4- [3- (R, S) -Fluoro-3- (3-aininomethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,4,6-trifluorophenylainino)ethyl]piperid-4- ylmethanol 4- [3- (R, S) -Fluoro-3- (3-aminomethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,4,5-trifluorophenylamino)ethyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-aminomethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,4,6-trifluorophenoxy)ethyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-aininomethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,4,5-trifluorophenoxy)ethyl]piperid-4- ylmethanol 4-[3-(R,S)-Fluoro-3-(3-aininomethyl-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]piperid- 4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-aininomethyl-6-methoxyquinolin-4- yl)propyl]-!-[3-(3,4,5-trifluorophenyl)prop-2-ynyl]piperid- 4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)propyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-morpliolinometliyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (3, 4, 5-trif luorophenyl)propyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-inorpliolinomet]iyl-6-methoxyquinolin-4-yl) propyl]-!- [2- (2,4, 6-trifluorophenyltliio) etliyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-inorp]iolinometliyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenylthio)ethyl]piperid-4-ylmethanol 4- [3- (R, S) -Fluoro-3- (3-morp]iolinometliyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (2, 4, 6-trifluoroptienylamino) etllyl]piperid-4-ylmet]lanol 4- [3- (R, S) -Fluoro-3- (3-morpholinoinet]iyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (3, 4, 5-trifluorophenylainino) etllyl]piperid-4-ylmet]lanol 4- [3- (R, S) -Fluoro-3- (3-morpholinomethyl-6-xnet]ioxyquinolin-4-yl)propyl] -1- [2- (2, 4, 6-trifluorophenoxy) et]lyl]piperid-4-ylInet]lanol 4- [3- (R, S) -Fluoro-3- (3-morp]iolinometliyl-6-xnethoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenoxy)ethyl]piperid-4-ylmethanol 4-[3-(R,S)-Fluoro-3-(3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]piperid-4-yImethanol 4- [3- (R, S) -Fluoro-3- (3-morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)prop-2-ynyl]piperid-4-ylmethanol 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-heptyl piperidine-4-hydroxamic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[4-phenylbutyl]piperidine-4-hydroxamic acid 4-[3-{3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[4-(2-fluorophenyl)propyl]piperidine-4-hydroxamic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[4-(3-fluorophenyl)propyl]piperidine-4-hydroxamic acid 4- [3- (3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (4-f luorop]ienyl)propyl]piperidine-4-]iydroxamic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[4-{4-fluorophenyl)butyl]piperidine-4-hydroxamic acid 4-[3-{3-Chloro-6-methoxyquinolin-4-yl)propyl]-l-[3-(2,3-difluorophenyl)propyl]piperidine-4-hydroxamic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[4-(2,3-difluorophenyl)propyl]piperidine-4-hydroxainic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,6-difluorophenyl)propyl]piperidine-4-hydroxamic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[4-(2,6-difluorophenyl)propyl]piperidine-4-hydroxamic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,5-difluorophenyl)propyl]piperidine-4-hydroxamic acid 4-[3-{3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)propyl]piperidine-4-hydroxamic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)propyl]piperidine-4-hydroxamic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3-(3,4, 5-trifluorophenyl)propyl]piperidine-4-liydroxamic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3-phenylt]iiopropyl]piperidine-4-tiydroxamic acid 4- [3- (3-Chloro-6-methoxyc[uinolin-4-yl)propyl] -1- [3- (2-f luorophenylt]iio)propyl]piperidine-4-liydroxamic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (3-f luorop]ienylt]iio)propyl]piperidine-4-]iydroxainic acid 4- [3- (3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- [2- (4-f luorophenylttiio) ethyl]piperidine-4-liydroxamic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1- [3- (4-fluorophenylttiio)propyl]piperidine-4-liydroxamic acid 4- [3- (3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- [2- (2, 3-dif luorophenyltliio) etliyl] piperidine-4-liydroxamic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (2, 3-difluorophenyltliio)propyl]piperidine-4-liydroxaraic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,6-difluorophenylthio)ethyl]piperidine-4-hydroxainic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenylthio)ethyl]piperidine-4-hydroxaxnic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2- (2,4,6-trifluorophenylthio)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1- [2- (3,4, 5-trif luoroptienyltliio) etliyl]piperidine-4-liydroxamic acid 4- [3- (3-chloro-6-inet]ioxyquinolin-4-yl)propyl] -1- [2- (2,3, 5-trif luorophenoxy) et]iyl]piperidine-4-]iydroxamic acid 4- [3- (3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,4, 6-trif luorophenoxy) et]iyl]piperidine-4-liydroxainic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [2- (3,4, 5-tr if luorophenoxy) et]iyl]piperidine-4-]iydroxainic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [2- (3 , 5- difluorophenylamino) etliyl]piperidine-4-]iydroxamic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,3, 5-trif luorophenylamino) etliyl]piperidine-4-]iydroxainic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,4, 6-trif luorophenylamino) ethyl] piper idine-4-liydroxamic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [2- (3,4, 5-trif luorophenylamino) etliyl]piperidine-4-liydroxamic acid 4- [3- (3-Chloro-6-met}ioxyquinolin-4-yl)propyl] -1- [3- (2, 6- difluorophenylthio)propyl]piperidine-4-]iydroxamic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2-chlorophenylthio)ethyl]piperidine-4-hydroxamic acid 4- [3- (3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (2-chlorophenyltliio)propyl]piperidine-4-hydroxamic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [2- (3-chloropllenylt]lio) etliyl]piperidine-4-hydroxamic acid 4- [3- (3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (3-ctilorophenyltliio) propyl ]piperidine-4-hydroxamic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(4-chlorophenylthio)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(4-chlorophenylthio)propyl]piperidine-4-hydroxamic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2-methylphenylthio)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2-methylphenylthio)propyl]piperidine-4-hydroxamic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3-methylphenylthio)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3-methylphenylthio)propyl]piperidine-4-hydroxamic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(4-methylphenylthio)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(4-methylphenylthio)propyl]piperidine-4-hydroxamic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2-trifluoromethylphenylthio)ethyl]piperidine-4-hydroxamic acid 4- [3- (3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (2-trif luoromethylphenylthio)propyl]piperidine-4-hydroxamic acid 4- [3- (3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- [2- (3-trifluoromethylphenylthio)ethyl]piperidine-4-hydroxamic acid 4- [3- (3-chloro-6-inetlioxyquinolin-4-yl)propyl] -1- [3- (3-trif luorometliylphenyltliio) propyl] piper idine-4-hydroxamic acid 4- [3- (3-chloro-6-metlaoxyquinolin-4-yl)propyl] -1- [2- (4-trif luorometiaylphenylthio) et]iyl]piperidine-4-liydroxamic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (4-trifluorometliylphenylttiio) propyl ]piperidine-4-liydroxamic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [2- (2-methoxyphenyltliio) etliyllpiperidine-4-liydroxamic acid 4- [3- (3-chloro-6-inetlioxyquinolin-4-yl)propyl] -1- [3- (2-methoxyphenyltliio)propyl]piperidine-4-liydroxamic acid 4- [3- (3-Chloro-6-inetlioxyquinolin-4-yl)propyl] -1- [2- (3-methoxyphenyltliio) ethyl]piperidine-4-liydroxainic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3-methoxyphenylthio)propyl]piperidine-4-hydroxamic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(4-methoxyphenylthio)ethyl]piperidine-4-hydroxainic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(4-methoxyphenylthio)propyl]piperidine-4-hydroxamic acid 4- [3- (3-C]aloro-6-methoxyquinolin'-4-yl)propyl] -1-[cyclopentylmetliyl] piperidine-4-hydroxamic acid 4-[3-(3-Chloro-5-methoxyquinolin-4-yl)propyl]-1-[2-(cyclopentyl)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(cyclopentyltliio) etliyl]piperidine-4-]iydroxamic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(cyclopentylthio)propyl]piperidine-4-}iydroxamic acid 4- [3- (3-chloro"6-methoxyquinolin-4-yl)propyl] -1- [3-(cyclohexyltliio)propyl]piperidine-4-hydroxainic acid 4- [3* (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [4-{thien-2-yl)butyl]piperidine-4-hydroxainic acid 4- [3- {3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- [3-(thien-2-yl) thiopropyl ] piperidine-4-liydroxamic acid 4- [3- (3-chloro-6-inet]ioxyquinolin-4-yl)propyl] -1- [3-{thien-3-yl) propyl] piperidine-4-liydroxamic acid 4- [3- {3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [4-(thien-3-yl) butyl]piperidine-4-hydroxainic acid 4-[3-{3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(thien-3-yl) t]iioethyl]piperidine-4-hydroxamic acid 4-[3-(3-Chloro-6-raethoxyquinolin-4-yl)propyl]-1-[3-{t]lien-3-yl) thiopropyl]piperidine-4-hydroxamic acid 4- [3- (3-chloro-6-inet]ioxyquinolin-4-yl) propyl] -l-[3-(l,3-tliiazol-2-yl)propyl]piperidine-4-liydroxainic acid 4- [3- (3-Chloro-6-inet]ioxyquinolin-4-yl)propyl] -l-[4-{l,3-tliiazol-2-yl)butyl]piperidine-4-liydroxamic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (1,3- thiazol-2-yl)thioethyl]piperidine-4-hydroxamic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(pyrid-2-yl)propyl]piperidine-4-hydroxamic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[4-(pyrid-2-yl)butyl]piperidine-4-hydroxainic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(pyrid-2-yl)thiopropyl]piperidine-4-hydroxamic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(pyrid-3-yl)propyl]piperidine-4-'hydroxamic acid 4- [3- (3-chloro-6-inet]ioxyquinolin-4-yl)propyl] -1- [4-(pyrid-3-yl)butyl]piperidine-4-liydroxamic acid 4- [3- {3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- [2-(pyrid-3-yl) tliioetliyl]piperidine-4-hydroxamic acid 4- [3- (3-chloro-6-inetlioxyquinolin-4-yl)propyl] -1- [3-(pyrid-3-yl) thiopropyl]piperidine-4-liydroxamic acid 4- [3- {3-Ctiloro-6-methoxyquinolin-4-yl)propyl] -1- [3-(pyrid-4-yl)propyl]piperidine-4-]lydroxaInic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [4-(pyrid-4-yl)butyl]piperidine-4-liydroxamic acid 4-[3-(3-Chloro-5-methoxyquinolin-4-yl)propyl]-1-[2-(pyrid-4-yl) tliioethyl]piperidine-4-hydroxaTnic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3-(pyrid-4-yl)thiopropyl]piperidine-4-hydroxamic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3-{pyrazin-2-yl)propyl]piperidine-4-]iydroxamic acid 4- [3- (3-chloro-6-inetlaoxyquinolin-4-yl)propyl] -1- [4-(pyrazin-2-yl) butyl ]piperidine-4-liydroxamic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(pyra2in-2-yl)thioethyl]piperidine-4-hydroxamic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-{pyrazin-2-yl) thiopropyl]piperidine-4-hydroxainic acid 4- [3- (3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (4-fluorophenyl)prop-2-ynyl]piperidine-4-hydroxamic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4-difluorophenyl)prop-2-ynyl]piperidine-4-liydroxainic acid 4- [3- (3-chloro-6-met]:ioxyquinolin-4-yl)propyl] -1- [3- (2, 4-difluorophenyl) prop-2-ynyl] piperidine-4-liydroxamic acid 4- [3- (3-Chloro-6-inet]ioxyquinolin-4-yl)propyl] -1- [3-(2,3, 5-trif luorop]ienyl)prop-2-ynyl]piperidine-4-hydroxamic acid 4- [3- (3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- [3-(2,4, 6-trif luorophenyl)prop-2-ynyl]piperidine-4-hydroxamic acid 4- [3- (3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- [3-(3,4, 5-trif luorophenyl) prop-2-ynyl] piper idine-4-hydroxamic acid 4- [3- (3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (4-chloro-3-fluoropheny1)prop-2-yny1]piperidine-4-hydroxami c acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3-chloro-4-fluorophenyl)prop-2-ynyl]piperidine-4-hydroxamic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2-chloro-4-fluorophenyl)prop-2-ynyl]piperidine-4-hydroxamic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3-chloro-5-fluorophenyl)prop-2-ynyl]piperidine-4-hydroxamic acid 4-[3-{3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(4-chloro-2-f luorophenyl)prop-2-ynyl]piperidine-4-hydroxainic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3-fluoro-4-methylphenyl)prop-2-ynyl]piperidine-4-hydroxamic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,5-bistrifluoromethylphenyl)prop-2-ynyl]piperidine-4-hydroxamic acid 4-[3-{3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(thien-2-yl)prop-2-ynyl]piperidine-4-hydroxainic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1- [3-(t]iien-3-yl) -2-ynyl]piperidine-4-]iydroxamic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(1,3-thiazol-2-yl)prop-2-ynyl]piperidine-4-hydroxamic acid 4- [3- (3-Chloro-6-methoxyquinolin-4-yl)propyl] -l-[3-(l,3-tliia2ol-4-yl)prop-2-ynyl]piperidine-4-hydroxamic acid 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [3- (1, 3-thiazol-5-yl)prop-2-ynyl]piperidine-4-]iydroxamic acid 4- [3- (3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- [3-(pyrid-2-yl)prop-2-ynyl]piperidine-4-hydroxamic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-{pyrid-3-yl )prop-2-ynyl]piperidine-4-]iydroxamic acid 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[3-(pyrid-4-yl)prop-2-ynyl]piperidine-4-hydroxamic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(cyclohexyl)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(phenyl)propyl]piperidine-4-hydroxamic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2 , 3 , 5-trifluorophenyl)propyl]piperidine-4-hydroxamic acid 4-[3-{3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluorophenylamino)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenylamino)ethyl]piperidine-4-hydroxamic acid 4- [3- (3-Methyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (3, 5-difluorophenoxy)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2 , 3 , 5-trifluorophenoxy)ethyl]piperidine-4-hydroxamic acid 4- [3- (3-Methyl-6-methoxyquinolin-4-yl)propyl] -1- [2-(cyclopentylthio)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(pyrid-2-yl)thioethyl]piperidine-4-hydroxamic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(thien-2-yl) thioethyl]piperidine-4-hydroxamic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]piperidine-4- hydroxamic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[3-( thien-2-yl)prop-2-ynyl]piperidine-4-hydroxamic acid 4- [3- (3-Fluoro-6-methoxyquinolin-4-yl)propyl] -1- [2-(cyclohexyl)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[3-(phenyl)propyl]piperidine-4-hydroxamic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)propyl]piperidine-4-hydroxamic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluorophenylamino)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2 , 3 , 5-trifluorophenylamino)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-l-[2-(3,5-difluorophenoxy)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenoxy)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenylthio)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2- (cyclopentylthio)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2- (pyrid-2-yl)thioethyl]piperidine-4-hydroxamic acid 4- [3- (3-Fluoro-6-methoxyquinolin-4-yl)propyl] -1- [2-(thien~2-yl) thioethyl]piperidine-4-hydroxainic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]piperidine-4-hydroxamic acid 4-[3-{3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[3-(thien-2-yl)prop-2-ynyl]piperidine-4-hydroxainic acid 4-[3-(3-Dimethylainino-6-methoxyquinolin-4-yl)propyl]-1-[2-(cyclohexyl)ethyl]piperidine-4-hydroxamic acid 4- [3- (3-Diraethylaruino-6-methoxyquinolin-4-yl)propyl] -1-[3-- (phenyl)propyl]piperidine-4-hydroxainic acid 4-[3-(3-Dimethylamino-6-methoxyquinolin"4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)propyl]piperidine-4-hydroxamic acid 4-[3-(3-Dimethylainino-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluorophenylamino)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenylamino)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Dimethylainino-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluorophenoxy)ethyl]piperidine-4-hydroxamic acid 4- [3- (3-Dimethylainino-6-methoxyquinolin-4-yl)propyl] -1-[2-(2,3,5-trifluorophenoxy)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Dimethylamino-6-methoxyquinolin-4-yl)propyl]-1- [2-(2,3,5-trifluorophenylthio)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Dimethylainino-6-methoxyquinolin-4-yl)propyl]-1-[2-(cyclopentylthio)ethyl]piperidine-4-hydroxamic acid 4- [3- {3-Dimethylainino-6-methoxyquinolin-4-yl)propyl] -1-[2- (pyrid-2-yl) thioethyl]piperidine-4-hydroxainic acid 4- [3- (3-Dimethylainino-6-methoxyquinolin-4-yl)propyl] -1-[2-(thien-2-yl)thioethyl]piperidine-4-hydroxamic acid 4-[3-(3-Dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]piperidine-4-hydroxamic acid 4-[3-(3-Dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[3-(thien-2-yl)prop-2-ynyl]piperidine-4-hydroxamic acid 4-[3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(cyclohexyl)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(phenyl)propyl]piperidine-4-hydroxamic acid 4-[3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)propyl]piperidine-4-hydroxamic acid 4-[3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluorophenylamino)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenylamino)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1- [2-(3,5-difluorophenoxy)ethyl]piperidine-4-hydroxamic acid 4-[3-{3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1- [2-(2,3,5-trifluorophenoxy)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1- [2-(2,3,5-trifluorophenylthio)ethyl]piperidine-4-hydroxamic acid 4-[3-{3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1- [2-(cyclopentylthio)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1- [2-(pyrid-2-yl)thioethyl]piperidine-4-hydroxamic acid 4-[3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1- [2- (thien-2-yl) thioethyl]piperidine-4-hydroxainic acid 4-[3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1- [3-(2,3,5-trifluorophenyl)prop-2-ynyl]piperidine-4- hydroxamic acid 4-[3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1- [3-(thien-2-yl)prop-2-ynyl]piperidine-4-hydroxamic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2- (cyclohexyl)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[3- (phenyl)propyl]piperidine-4-hydroxamic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[3- (2,3,5-trifluorophenyl)propyl]piperidine-4-hydroxamic acid 4- [3- (3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (3 , 5-dif luorop]ienylamino) et]ayl]piperidine-4-liydroxainic acid 4- [3- (3-Fluorometliyl-6-methoxyquinolin-4-yl)propyl] -1- [2-(2,3, 5-trif luorophenylamino) etliyl]piperidine-4-hydroxamic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluorophenoxy)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2 , 3 , 5-trifluorophenoxy)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenylthio)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(cyclopentylthio)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(pyrid-2-yl) thioethyl]piperidine-4-hydroxamic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(thien-2-yl)thioethyl]piperidine-4-hydroxamic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2 , 3 , 5-trifluorophenyl)prop-2-ynyl]piperidine-4-hydroxamic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(thien-2"yl)prop-2-ynyl]piperidine-4-hydroxamic acid 4-[3-(3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(cyclohexyl)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3- (phenyl)propyl]piperidine-4-hydroxamic acid 4-[3-(3-Aininomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)propyl]piperidine-4-hydroxamic acid 4-[3-(3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluorophenylamino)ethyl]piperidine-4-hydroxainic acid 4-[3-(3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2 , 3 , 5-trifluorophenylamino)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluorophenoxy)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2 , 3 , 5-trifluorophenoxy)ethyl]piperidine-4-hydroxamic acid 4- [3- (3-Aminomethyl-6-methoxyquinolin-4-yl)propyl] -1- [2-(2 , 3 , 5-trifluorophenylthio)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(cyclopentylthio)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(pyrid-2-yl)thioethyl]piperidine-4-hydroxamic acid 4-[3-(3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(thien-2-yl)thioethyl]piperidine-4-hydroxamic acid 4-[3-(3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]piperidine-4-hydroxamic acid 4-[3-{3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3- (thien-2-yl)prop-2-ynyl]piperidine-4-hydroxainic acid 4-[3-{3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl]- 1-[2-(cyclohexyl)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl]- 1-[3-(phenyl)propyl]piperidine-4-hydroxamic acid 4-[3-{3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl]- 1-[3-(2,3,5-trifluorophenyl)propyl]piperidine-4- hydroxamic acid 4- [3- (3-Morpholinomethyl-6-xnethoxyquinolin-4-yl)propyl] - 1-[2-(3,5-difluorophenylamino)ethyl]piperidine-4- hydroxamic acid 4-[3-(3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl]- 1-[2-(2,3,5-trifluorophenylamino)ethyl]piperidine-4- hydroxamic acid 4-[3-(3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl]- 1-[2-(3,5-difluorophenoxy)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl]- 1-[2-(2,3,5-trifluorophenoxy)ethyl]piperidine-4- hydroxamic acid 4-[3-(3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl]- 1-[2-(2,3,5-trifluorophenylthio)ethyl]piperidine-4- hydroxamic acid 4-[3-(3-Morpholinomethy1-6-methoxyquinolin-4-y1)propyl]- 1-[2-(cyclopentylthiol)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl]- 1-[2-(pyrid-2-yl)thioethyl]piperidine-4-hydroxamic acid 4-[3-(3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(thien-2-yl)thioethyl]piperidine-4-hydroxamic acid 4-[3-(3-Morpholinomethy1-6-methoxyquinolin-4-y1)propyl]-1-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]piperidine-4-hydroxamic acid 4- [3- (3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl] -1-[3-(thien-2-yl)prop-2-ynyl]piperidine-4-hydroxamic acid 4- [3- (3-Methyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (2,4,6-trifluorophenyl)propyl]piperidine-4-hydroxainic acid 4- [3- (3-Methyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (3,4,5-trifluorophenyl)propyl]piperidine-4-hydroxamic acid 4- [3- (3-Methyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,4,6-trifluorophenylthio)ethyl]piperidine-4-hydroxamic acid 4- [3- (3-Methyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (3,4,5-trifluorophenylthio)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[2- (2,4,6-trifluorophenylamino)ethyl]piperidine-4-hydroxamic acid 4- [3- (3-Methyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (3,4,5-trifluorophenylamino)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[2- (2,4,6-trifluorophenoxy)ethyl]piperidine-4-hydroxamic acid 4- [3- (3-Methyl-6-methoxyquinolin-4-yl)propyl] -1- [2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]piperidine-4-hydroxamic acid 4-[3-(3-Methyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)prop-2-ynyl]piperidine-4-hydroxamic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)propyl]piperidine-4-hydroxamic acid 4- [3- (3-Fluoro-6-methoxyquinolin-4-yl)propyl] -1- [3-(3,4,5-trifluorophenyl)propyl]piperidine-4-hydroxamic acid 4- [3- (3-Fluoro-6-methoxyquinolin-4-yl)propyl] -1- [2-(2,4,6-trifluorophenylthio)ethyl]piperidine-4-hydroxamic acid 4- [3- (3-Fluoro-6-methoxyquinolin-4-yl)propyl] -1- [2-(3,4,5-trifluorophenylthio)ethylIpiperidine-4-hydroxamic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenylamino)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2- (3,4, 5-trif luorophenylamino) et]xyl]piperidine-4-liydroxainic acid 4-[3-(3-Fluoro-5-methoxyquinolin-4-yl)propyl]-1-[2-(2,4, 6-trif luorophenoxy) etlxyl]piperidine-4-hydroxamic acid 4- [3- (3-Fluoro-6-inetlioxyquinolin-4-yl)propyl] -1- [2-(3,4, 5-trif luoroplxenoxy) et]xyl]piperidine-4-hydroxamic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4, 6-trif luorop-lenyl)prop-2-ynyl]piperidine-4-]lydr oxami c acid 4- [3- (3-Fluoro-6-met]xoxyquinolin-4-yl)propyl] -1- [3-(3,4, 5-trifluorophenyl)prop-2-ynyl]piperidine-4-liydroxamic acid 4- [3- (3-Dimethylainino-6-inet]ioxyquinolin-4-yl)propyl] -1-[3- (2 , 4, 6-trifluorophenyl)propyl]piperidine-4-liydroxamic acid 4- [3- (3-Dimethylamino-6-methoxyquinolin-4-yl)propyl] -1-[3-(3,4,5-trifluorophenyl)propyl]piperidine-4-hydroxamic acid 4- [3- (3-Diinet]iylamino-6-metlxoxyquinolin-4-yl)propyl] -1-[2- (2, 4, 6-trif luoropllenylt]lio)etllyl]piperidine-4-llydroxamic acid 4- [3- (3-Dimethylamino-6-methoxyquinolin-4-yl)propyl] -1-[2- (3 , 4, 5-trif luoroplxenyltliio) ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Dimethylaxnino-6-methoxyquinolin-4-yl)propyl]-1- [2-(2,4,6-trifluorophenylamino)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenylamino)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenoxy)ethyl]piperidine-4-hydroxamic acid 4- [3- (3-Dimethylamino-6-methoxyquinolin-4-yl)propyl] -1-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]piperidine-4-hydroxamic acid 4-[3-(3-Dimethylainino-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)prop-2-ynyl]piperidine-4-hydroxamic acid 4-[3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)propyl]piperidine-4-hydroxainic acid 4- [3- (3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl] -1-[2-(2,4,6-trifluorophenylthio)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenylthio)ethyl]piperidine-4-hydroxamic acid 4- [3- (3-Hydroxymethyl-6-methoxyquinolin-4-yl) propyl] -1- [2-(2,4,6-trifluorophenylamino)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[2- (3,4, 5-trif luorophenylamino) ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenoxy)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4-hydroxamic acid 4- [3- (3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl] -1-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]piperidine-4-hydroxamic acid 4-[3-(3-Hydroxymethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)prop-2-ynyl]piperidine-4-hydroxaxnic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4, 6-trifluorophenyl)propyl]piperidine-4-hydroxainic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-( 3 , 4 , 5-trifluorophenyl)propyl]piperidine-4-hydroxamic acid 4- [3- (3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl] -1- [2-(2 , 4, 6-trifluorophenylthio)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2- (3,4,5-trifluorophenylthio)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenylamino)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenylamino)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenoxy)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]piperidine-4-hydroxamic acid 4-[3-(3-Fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)prop-2-ynyl]piperidine-4-hydroxamic acid 4-[3-(3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)propyl]piperidine-4-hydroxamic acid 4-[3-(3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)propyl]piperidine-4-hydroxamic acid 4-[3-(3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2- (2,4,6-trifluorophenylthio)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-1- [2-(3,4,5-trifluorophenylthio)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenylamino)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3 , 4 , 5-trifluorophenylamino)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenoxy)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4-hydroxamic acid 4-[3-(3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]piperidine-4-hydroxamic acid 4-[3-(3-Aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)prop-2-ynyl]piperidine-4-hydroxamic acid 4-[3-(3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)propyl]piperidine-4-hydroxamic acid 4-[3-(3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl]- 1- [3- (3,4, 5-trif luorophenyl)propyl]piperidirLe-4- hydroxamic acid 4-[3-(3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl]- 1-[2-(2,4,6-trifluorophenylthio)ethyl]piperidine-4- hydroxaiuic acid 4- [3- (3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl]- 1-[2-(3,4,5-trifluorophenylthio)ethyl]piperidine-4- hydroxamic acid 4- [3- (3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl] - 1-[2-(2,4,6-trifluorophenylamino)ethyl]piperidine-4- hydroxamic acid 4-[3-(3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl]- 1-[2-(3,4,5-trifluorophenylamino)ethyl]piperidine-4- hydroxamic acid 4-[3-(3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl]- 1-[2-(2,4,6-trifluorophenoxy)ethyl]piperidine-4- hydroxamic acid 4-[3-(3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl]- 1-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4- hydroxamic acid 4-[3-(3-Morpholinomethyl-6-methoxyquinolin-4-yl)propyl]- 1-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]piperidine-4- hydroxamic acid 4-[3-(3-Morpholinomethy1-6-methoxyquinolin-4-y1)propyl]- 1-[3-(3,4,5-trifluorophenyl)prop-2-ynyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-heptyl piperidine-4-hydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [4-plaenylbutyl]piperidine-4-liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [3- (phenyl)propyl]piperidine-4-hydroxamic acid 4- [3- (R, S) -Hydroxy-3- {3-chloro-6-methoxyquinolin-4-yl) - propyl]-1-[4-(2-fluorophenyl)propyl]piperidine-4- hydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-inet]:ioxyquinolin-4-yl) - propyl]-1-[4-{3-fluorophenyl)propyl]piperidine-4- liydroxainic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [3- {4-fluorophenyl)propyl]piperidine-4- liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [4- (4-fluorophenyl)butyl]piperidine-4- liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [3- (2 , 3-di fluorophenyl) propyl ] piperidine-4- liydroxamic acid 4- [3- (R, S) -Hydroxy-3- {3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [4- (2 , 3-dif luoroptienyl)propyl]piperidine-4- liydroxami c acid 4-[3-(R,S)-Hydroxy-3-{3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[3-(2,6-difluorophenyl)propyl]piperidine-4- hydroxamic acid 4- [3- (R, S) -Hydroxy-3- {3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [4- (2 , 5-dif luoropJienyl) propyl J piperiaine-4-]iydroxami c acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) -propyl] -1- [3- (3, 5-dif luoroplaenyl) propyl] piperidine-4-liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) -propyl] -1- [3- (2 , 3 , 5-trifluorophenyl)propyl]piperidine-4-liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) -propyl] -1- [3-p]ienylt]iiopropyl]piperidine-4-]iydroxainic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) -propyl] -1- [3- (2-f luorophenyltliio) propyl] piper idine-4-Jiydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) -propyl] -1- [3- (3-f luorophenyl tliio) propyl] piper idine-4-hydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) -propyl] -1- [2- (4-f luorophenylthio) et-lyl]piperidine-4-]lydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) -propyl] -1- [3- (4-f luorophenyltliio)propyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)-propyl]-1-[2-(2,3-difluorophenylthio)ethyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[3-(2,3-difluorophenylthio)propyl]piperidine-4- hydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl]-1-[2-(2,6-difluorophenylthio)ethyl]piperidine-4- hydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-rr\ethoxyquinolin-4-yl) - propyl]-1-[2-(2,3,5-trifluorophenylthio)ethyl]piperidine- 4-hydroxainic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(2,4,6-trifluorophenylthio)ethyl]piperidine- 4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(3,4,5-trifluorophenylthio)ethyl]piperidine- 4-hydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl]-1-[2-(3,5-difluorophenoxy)ethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(2,3,5-trifluorophenoxy)ethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(2,4,6-trifluorophenoxy)ethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(3,5-difluorophenylamino)ethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(2,3,5-trifluorophenylamino)ethyl]- piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(2,4,6-trifluorophenylamino)ethyl]- piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(3,4,5-trifluorophenylamino)ethyl]- piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[3-(2,6-difluorophenylthio)propyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(2-chlorophenylthio)ethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[3-(2-chlorophenylthio)propyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(3-chlorophenylthio)ethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[3-(3-chlorophenylthio)propyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(4-chlorophenylthio)ethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl] -1- [3- (4-chlorophenyltliio)propyl]piperidine-4- liydroxamic acid 4- [3- (R, S) -Hydroxy-3- {3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [2- (2-methylp]ienylthio) et]iyl]piperidine-4- hydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [3- (2-metliylphenylthio) propyl] piper idine-4- liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-~6-methoxyquinolin-4-yl) - propyl] -1- [2- (3-inet]aylphenyltl:iio) etliyl]piperidine-4- hydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [3- (3-methylphenyltliio)propyl]piperidine-4- tiydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-iuethoxyquinolin-4-yl) - propyl] -1- [2- (4-inet]iylphenylt]iio) ethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[3-(4-methyIphenylthio)propyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(2-trifluoromethylphenylthio)ethyl]- piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[3-(2-trifluoromethylphenylthio)propyl]- piperidine-4-liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-inet]ioxyquinolin-4-yl) - propyl] -1- [2- (3-trif luoroxnetlaylphenyltliio) ethyl] - piperidine-4-hydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [3- (3-trifluoroinetliylphenyltliio)propyl] - piperidine-4-liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-inet]ioxyquinolin-4-yl) - propyl] -1- [2- (4-trif luorometliylphenyltliio) ethyl] - piperidine-4-liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [3- (4-trif luorometliylphenyltliio)propyl] - piperidine-4-liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [2- (2-methoxyphenyltliio) et]iyl]piperidine-4- liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl ] -1 - [ 3- (2-methoxyphenyltliio) propyl ] piperidine-4- hydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [2- (3-methoxyp]ienyltliio) et]iyl]piperidine-4- liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [3- (3-methoxyphenyltliio)propyl]piperidine-4- liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [2- (4-methoxyptienyltl:aio) etliyl]piperidine-4- liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [3- (4-metlaoxyphenylthio)propyl]piperidine-4- liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-inet]ioxyquinolin-4-yl) - propyl] -1- [cyclopentylmethyl]piperidine-4-laydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-niet]ioxyquinolin-4-yl) - propyl]-!- [2- (cyclopentyl) et]iyl]piperidine-4-liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [2- (cyclohexyl) et]iyl]piperidine-4-hydroxainic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [2- (cyclopentyl thio) etliyl] piper idine-4- ]iydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [3- (cyclopentyltliio)propyl]piperidine-4- laydroxamic acid 4- [3- (R, S) -Hydroxy-3' (3-chloro-6-inet]ioxyquinolin-4-yl) - propyl] -1- [3- (cyclohexyltliio)propyl]piperidine-4- hydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-rnet]ioxyquinolin-4-yl) - propyl] -1- [2- (pyrid-2-yl) tliioet]iyl]piperidine-4- liydroxamic acid 4- [3- (R/ S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [4- (thien-2-yl) butyl] piper idine-4-hydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [3- (thien-2-yl) t]iiopropyl]piperidine-4- hydroxamic acid 4- [3- (R, S) -Hydroxy-3- {3-c]aloro-6-methoxyquinolin-4-yl) - propyl]-1-[3-(thien-3-y1)propyl]piperidine-4-hydroxami c acid 4-[3-(R,S)-Hydroxy-3-{3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[4-(thien-3-yl)butyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(thien-2-yl)thioethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[2-{thien-3-yl)thioethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[3-(thien-3-yl)thiopropyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Hydroxy-3-{3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[3-(1,3-thiazol-2-yl)propyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[4-(1,3-thiazol-2-yl)butyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[3-(1,3-thiazol-2-yl)thioethyl]piperidine-4- hydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-inetlioxyquinolin-4-yl) - propyl]-1-[3-(pyrid-2-yl)propyl]piperidine-4-hydroxamic acid 4- [3- (R, S) -Hydroxy-3- {3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [4- (pyrid-2-yl)butyl]piperidine-4-hydroxainic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [3- (pyrid-2-yl) thiopropyl]piperidine-4- hydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl]-1-[3-(pyrid-3-yl)propyl]piperidine-4-hydroxamic acid 4- [3- (R, S) -Hydroxy-3- {3-chloro-6-methoxyquinolin-4-yl) - propyl]-1-[4-(pyrid-3-yl)butyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(pyrid-3-yl)thioethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[3-(pyrid-3-yl)thiopropyl]piperidine-4- hydroxamic acid 4-[3-(R;S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[3-(pyrid-4-yl)propyl]piperidine-4-hydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [4- {pyrid-4-yl)butyl]piperidine-4-hydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [2- (pyrid-4-yl) thioet]iyl]piperidine-4- liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl]-1-[3-(pyrid-4-yl)thiopropyl]piperidine-4- hydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [3- {pyra2in-2-yl)propyl]piperidine-4-liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl]-1-[4-(pyrazin-2-yl)butyl]piperidine-4-hydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [2- (pyra2in-2-yl) tliioethyllpiperidine-4- liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-n\et]ioxyquinolin-4-yl) - propyl] ~1- [3- (pyrazin-2-yl) t]iiopropyl]piperidine-4- liydroxairiic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [3- (4-f luorop]ienyl)prop-2-ynyl]piperidine-4- hydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [3- (3 , 4-difluorophenyl)prop-2-ynyl] piperidine- 4-liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [3- (2 , 4-dif luorophenyl)prop-2-ynyl]piperidine- 4-hydroxamic acid 4-[3-(R,S)-Hydroxy~3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]- piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl] -1- [3- (2,4, 6-trif luorophenyl)prop-2-ynyl] - piperidine-4-liydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[3-(3,4,5-trifluorophenyl)prop-2-ynyl]- piper idine-4-liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-inet]ioxyquinolin-4-yl) - propyl] -1- [3- (4-chloro-3-f luorophenyl)prop-2-ynyl] - piperidine-4-tiydroxainic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [3- (3-chloro-4-fluorophenyl)prop-2-ynyl] - piperidine-4-laydroxainic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-inetlioxyquinolin-4-yl) - propyl] -1- [3- (2-chloro-4-f luorophenyl)prop-2-ynyl] - piperidine-4-liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl]-1-[3-(3-chloro-5-fluorophenyl)prop-2-ynyl]- piper idine-4-liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [3- (4-chloro-2-fluorophenyl)prop-2-ynyl] - piperidine-4-liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [3- (3-f luoro-4-metliylphenyl )prop-2-ynyl] - piperidine-4-]iydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl]-1-[3-(3,5-bistrifluoromethylphenyl)prop-2-ynyl]- piperidine-4-liydroxainic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl]-1-[3-(thien-2-yl)prop-2-ynyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl] -1- [3- (thien-3-yl)prop-2-ynyl]piperidine-4- liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-inetlioxyquinolin-4-yl) - propyl]-1-[3-(1,3-t]iiazol-2-yl)prop-2-ynyl]piperidine-4- hydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-inetlioxyquinolin-4-yl) - propyl]-1-[3-(1,3-t]iiazol-4"yl)prop-2-ynyl]piperidine-4- liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-inet]ioxyquinolin-4-yl) - propyl] -1- [3- (1, 3-tliiazol-5-yl)prop-2-ynyl]piperidine-4- hydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl]-1-[3-(pyrid-2-yl)prop-2-ynyl]piperidine-4- hydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-met]:ioxyquinolin-4-yl) - propyl]-1-[3-(pyrid-3-yl)prop-2-ynyl]piperidine-4- liydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[3-(pyrid-4-yl)prop-2-ynyl]piperidine-4- liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-inetliyl-6-methoxyquinolin-4-yl) - propyl] -1- [2- (cyclohexyl) ethyl]piperidine-4-]iydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-met]iyl-6-inet]ioxyquinolin-4-yl) - propyl] -1- [3- (plnenyl)propyl]piperidine-4-liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-xnet]nyl-6-methoxyquinolin-4-yl) - propyl] -1- [3- (2,3, 5-trif luorophenyl)propyl]piperidine-4- liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-met]iyl-6-methoxyquinolin-4-yl) - propyl] -1- [2- (3 , 5-dif luorophenylamino) etliyl]piperidine-4- tiydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-metliyl-6-inettioxyquinolin-4-yl) - propyl] -1- [2- (2, 3, 5-tr if luorophenylamino) etlayl] - piperidine-4-liydroxainic acid 4- [3- (R, S) -Hydroxy-3- (3-metliyl-6-methoxyquinolin-4-yl) - propyl] -1- [2- (3 , 5-dif luorophenoxy) etliyl]piperidine-4- liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-inetliyl-6-methoxyquinolin-4-yl) - propyl] -1- [2- (2,3, 5-trif luorophenoxy) etliyl]piperidine-4- liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-methyl-6-inet]ioxyquinolin-4-yl) - propyl] -1- [2- (2,3, 5-trif luoroptienyltliio) ethyl] piperidine- 4-hydroxainic acid 4-[3-(R,S)-Hydroxy-3-(3-methyl-6-methoxyquinolin-4-yl)- propyl]-1-[2-(cyclopentylthio)ethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-methyl-6-methoxyquinolin-4-yl)- propyl]-1-[2-(pyrid-2-yl)thioethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-methyl-6-methoxyquinolin-4-yl)- propyl]-1-[2-(thien-2-yl)thioethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-methyl-6-methoxyquinolin-4-yl)- propyl]-1-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]- piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-methyl-6-methoxyquinolin-4-yl)- propyl]-1-[3-(thien-2-yl)prop-2-ynyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(cyclohexyl)ethyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)- propyl]-1-[3-(phenyl)propyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)- propyl]-1-[3-(2,3,5-trifluorophenyl)propyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(3,5-difluorophenylamino)ethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(2,3,5-trifluorophenylamino)ethyl]- piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)- propyl] -1- [2- (3 , 5-dif luorop]:ienoxy) ethyl]piperidine-4- tiydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-f luoro-6-methoxyquinolin-4-yl) - propyl]-1-[2-(2,3,5-trifluorophenoxy)ethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(2,3,5-trifluorophenylthio)ethyl]piperidine- 4-hydroxamic acid 4-[3-{R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(cyclopentylthio)ethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro~6-methoxyquinolin-4-yl)- propyl]-1-[2-(pyrid-2-yl)thioethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(thien-2-yl)thioethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)- propyl]-1-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]- piperidine-4-hydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-f luoro-6-methoxyquinolin-4-yl) - propyl]-1-[3-(thien-2-yl)prop-2-ynyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-dimethylamino-6-methoxyquinolin- 4-yl)propyl]-1-[2-(cyclohexyl)ethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-dimethylamino-6-methoxyquinolin- 4-y1)propyl]-1-[3-(phenyl)propyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)-propyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluorophenylamino)-ethyl]piperidine-4-hydroxainic acid 4- [3- (R, S) -Hydroxy-3- (3-dimethylainino-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenylamino) ethyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluorophenoxy)ethyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenoxy)ethyl]-piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenylthio)-ethyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[2-(cyclopentylthio)ethyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[2-(pyrid-2-yl)thioethyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-dimethylamino-6-methoxyquinolin- 4-yl)propyl]-1-[2-(thien-2-yl)thioethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-dimethylamino-6-methoxyquinolin- 4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]- piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-dimethylainino-6-methoxyquinolin- 4-yl)propyl] -1- [3- (t]iien-2-yl)prop-2-ynyl]piperidine-4- liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-liydroxyinetliyl-6-inet]ioxyquinolin- 4-yl)propyl] -1- [2- (cyclohexyl) etliyl]piperidine-4- liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-hydroxyTnetliyl-6-xnetlioxyquinolin- 4-yl)propyl] -1- [3- (phenyl)propyl]piperidine-4-hydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-liydroxyTnethyl-6-methoxyquinolin- 4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)- propyl]piperidine-4-]iydroxamic acid 4- [3- (R,S) -Hydroxy-3- (3-]iydroxymetliyl-6-methoxyquinolin- 4-yl)propyl]-1-[2-(3,5-difluorophenylamino)ethyl]- piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-hydroxymethyl-6-methoxyquinolin- 4-yl)propyl]-1-[2-(2,3,5-trifluorophenylamino)ethyl]- piperidine-4-hydroxaxnic acid 4-[3-(R,S)-Hydroxy-3-(3-hydroxymethyl-6-methoxyquinolin- 4-yl)propyl]-1-[2-(3,5-difluorophenoxy)ethyl]piperidine- 4-hydroxainic acid 4- [3- (R, S) -Hydroxy-3- (3-hydroxymethyl-6-methoxyquinolin- 4-yl) propyl] -1- [2- (2,3, 5-trif luorophenoxy) -et]iyl]piperidine-4-hydroxainic acid 4- [3- (R, S) -Hydroxy-3- (3-hydroxymetliyl-6-inet]ioxyquinolin-4-yl)propyl] -1- [2- (2 , 3, 5-trif luorophenylthio) -etliyl]piperidine-4-hydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-hydroxyTnetliyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (cyclopentyltliio) et]iyl]piperidine-4-hydroxamic acid 4- [3- (R,S) -Hydroxy-3- (3-hydroxyinet]iyl-6-xnethoxyquinolin-4-yl)propyl] -1- [2- (pyrid-2-yl) t]iioet]iyl]piperidine-4-hydroxamic acid 4- [3- (R,S) -Hydroxy-3- (3-]iydroxymet]iyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (thien-2-yl) tliioethyl]piperidine-4-liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-]iydroxymet]iyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorop]ienyl)prop-2-ynyl]-piperidine-4-liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-liydroxymet]iyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (t]iien-2-yl)prop-2-ynyl]piperidine-4-liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-f luoromet]iyl-6-inet]ioxyquinolin-4-yl)propyl]-1-[2-(cyclohexyl)ethyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl] -1-[3-(phenyl)propyl]piperidine-4-hydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-f luoromethyl-6-methoxyquinolin-4- yl)propyl] -1- [3- (2, 3, 5-trif luorophenyl)propyl]piperidine-4-liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-f luorometliyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (3, 5-dif luorophenylamino) etliyl] -piperidine-4-]iydroxainic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenylamino)ethyl]-piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluorophenoxy)ethyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yl) propyl] -1-[2-(2,3,5-trifluorophenoxy)ethyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenylthio)ethyl]-piperidine-4-hydroxainic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(cyclopentylthio)ethyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yDpropyl] -1- [2- (pyrid-2-yl) thioethyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl] -1-[2-(thien-2-yl)thioethyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4- yl)propyl] -1- [3- (2,3, 5-trif luorophenyl)prop-2-ynyl] - piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4- yl) propyl] -1- [3- (thien-2-yl) prop-2-ynyl] piper idine-4- liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-aminometliyl-6-methoxyquinolin-4- yDpropyl] -1- [2- (cyclotiexyl) etliyl]piperidine-4-]iydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-aininomet]iyl-6-methoxyquinolin-4- yl)propyl] -1- [3- (phenyl)propyl]piperidine-4-l:aydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-aminoinetliyl-6-methoxyquinolin-4- yl) propyl] -1- [3- (2, 3, 5-trif luorophenyl) propyl] piper idine- 4-liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-aminomet]iyl-6-methoxyquinolin-4- yl) propyl] -1- [2- (3, 5-dif luorophenylainino) ethyl] - piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-aininomethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,3,5-trifluorophenylamino)ethyl]- piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-aminomethyl-6-methoxyquinolin-4- yDpropyl] -1- [2- (3, 5-dif luorophenoxy) ethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-aminomethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,3,5-trifluorophenoxy)ethyl]piperidine- 4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-aminomethyl-6-methoxyquinolin-4- yl)propyl] -1- [2- (2, 3 , 5-trif luoroptienyltliio) etliyl] - piperidine-4-]iydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-aminomet]iyl-6-methoxyquinolin-4- yl)propyl] -1- [2- (cyclopentyltliio) et]iyl]piperidine-4- liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-aminomethyl-6-methoxyquinolin-4- yl)propyl] -1- [2- (pyrid-2-yl) tliioet]iyl]piperidine-4- hydroxamic acid 4- [3- (R, S) -Hydroxy-3- {3-aminometliyl-6-methoxyquinolin-4- yDpropyl] -1- [2- (thien-2-yl) thioettayl]piperidine-4- liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-aminoinet]iyl-6-methoxyquinolin-4- yDpropyl] -1- [3- (2,3, 5-trif luorophenyl)prop-2-ynyl] - piperidine-4-liydroxainic acid 4- [3- (R, S) -Hydroxy-3- (3-aminoinethyl-6-methoxyquinolin-4- yDpropyl] -1- [3- (thien-2-yl)prop-2-ynyl]piperidine-4- liydroxamic acid 4- [3- (R, S) -Hydroxy-3- {3-morpliolinomet]iyl-6-inetlioxy- quinolin-4-yl)propyl] -1- [2- (cyclotiexyl) etliyl]piperidine- 4-hydroxarnic acid 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxy- quinolin-4-yl)propyl] -1- [3- (plaenyl)propyl]piperidine-4- liydroxamic acid 4- [3- {R,S) -Hydroxy-3- {3-morp]iolinomethyl-6-methoxy- quinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)- propyl]piperidine-4-hydroxamic acid 4- [3- (R,S) -Hydroxy-3- (3-morp]iolinomet]iyl-6-mettioxy- quinolin-4-yl)propyl] -1- [2- (3 , 5-dif luorophenylamino) - etliyl]piperidine-4-]nydroxainic acid 4- [3- (R, S) -Hydroxy-3- (3-morp]iolinomet]iyl-6-methoxy- quinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenyl- amino) et]iyl]piperidine-4-]iydroxainic acid 4- [3- (R, S) -Hydroxy-3- {3-morpholinomethyl-6-methoxy- quinolin-4-yl)propyl] -1- [2- (3 , 5-dif luorophenoxy) - etliyl] piperidine-4-]iydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-morpliolinomethyl-6-inet]ioxy- quinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenoxy)- ethyl]piperidine-4-hydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-morp]iolinometliyl-6-methoxy- quinolin-4-yl)propyl] -1- [2- (2, 3 , 5-trif luorophenyltiiio) - etliyl]piperidine-4-liydroxamic acid 4- [3- (R,S) -Hydroxy-3- (3-morp]iolinoinet]iyl-6-methoxy- quinolin-4-yl)propyl] -1- [2- (cyclopentyltliio) etJiyl] - piperidine-4-liydroxainic acid 4- [3- (R,S) -Hydroxy-3- (3-morpholinomet]iyl-6-methoxy- quinolin-4-yl)propyl] -1- [2- (pyrid-2-yl) tliioetliyl] - piperidine-4-hydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-morp]iolinometliyl-6-methoxy- quinolin-4-yl)propyl] -1- [2- {tlaien-2-yl) tliioetliyl] - piperidine-4-hydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-morp]iolinomet]iyl-6-methoxy- quinolin-4-yl)propyl] -1- [3- (2 , 3, 5-trif luorophenyl)prop-2- ynyl]piperidine-4-liydroxainic acid 4- [3- (R, S) -Hydroxy-3- (3-morpliolinomethyl-6-inetlioxy- quinolin-4-yl)propyl]-1-[3-(thien-2-yl)prop-2-ynyl]- piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-methyl-6-methoxyquinolin-4-yl)- propyl]-1-[3-(2,4,6-trifluorophenyl)propyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-methyl-6-methoxyquinolin-4-yl)- propyl]-1-[3-(3,4,5-trifluorophenyl)propyl]piperidine-4- hydroxamic acid 4- [3- (R, S) -Hydroxy-3" (3-methyl-6-methoxyquinolin-4-yl) - propyl]-1-[2-(2,4,6-trifluorophenylthio)ethyl]piperidine- 4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-methyl-6-methoxyquinolin-4-yl)- propyl]-1-[2-(3,4,5-trifluorophenylthio)ethyl]piperidine- 4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-methyl-6-methoxyquinolin-4-yl)- propyl]-1-[2-(2,4,6-trifluorophenylamino)ethyl]- piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-methyl-6-methoxyquinolin-4-yl)- propyl]-1-[2-(3,4,5-trifluorophenylamino)ethyl]- piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-methyl-6-methoxyquinolin-4-yl)- propyl]-1-[2-(2,4,6-trifluorophenoxy)ethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-methyl-6-methoxyquinolin-4-yl)- propyl]-1-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-methyl-6-methoxyquinolin-4-yl)- propyl]-1-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]- piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-methyl-6-methoxyquinolin-4-yl)- propyl]-1-[3-(3,4,5-trifluorophenyl)prop-2-ynyl]- piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)- propyl]-1-[3-(2,4,6-trifluorophenyl)propyl]piperidine-4- hydroxamic acid 4-[3~(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)- propyl]-1-[3-(3,4,5-trifluorophenyl)propyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(2,4,6-trifluorophenylthio)ethyl]piperidine- 4-hydroxainic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(3,4,5-trifluorophenylthio)ethyl]piperidine- 4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(2,4,6-trifluorophenylamino)ethyl]- piperidine-4-hydroxainic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(3,4,5-trifluorophenylamino)ethyl]- piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(2,4,6-trifluorophenoxy)ethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)- propyl] -1- [2- (3 , 4, 5-trif luoroptienoxy) et]:iyl]piperidine-4-]iydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoro-6-methoxyquinolin-4-yl)-propyl]-1-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]-piperidine-4-tiydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-f luoro-6-inetlioxyquinolin-4-yl) -propyl]-l-[3-(3,4,5-tri fluoropheny1)prop-2-yny1]-piperidine-4-liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-dimetliylamino-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)propyl]-piperidine-4-liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-dimetliylamino-6-methoxyquinolin-4-yl)propyl] -1- [3- (3 , 4, 5-trif luorophenyl)propyl] -piperidine-4-hydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-dimet]iylamino-6-methoxyquinolin-4-yl)propyl]-l-[2-(2,4, 6-trifluorophenylthio) -ethyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-dimethylainino-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenylthio)ethyl]-piperidine-4-hydroxainic acid 4-[3-(R/S)-Hydroxy-3-(3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[2-{2,4,6-trifluorophenylamino)ethyl]-piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-dimethylamino-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenylamino) ethyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-dimethylainino-6-methoxyquinolin- 4-yl)propyl]-1-[2-(2,4,6-trifluorophenoxy)- ethyl]piperidine-4-hydroxamic acid 4-[3-(R,S)1Hydroxy-3-(3-dimethylamino-6-methoxyquinolin- 4-yl)propyl]-1-[2-(3,4,5-trifluorophenoxy)- ethyl]piperidine-4-hydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-dimethylainino-6-methoxyquinolin- 4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]- piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-dimethylamino-6-rnethoxyquinolin- 4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)prop-2-ynyl]- piperidine-4-hydroxainic acid 4- [3- (R, S) -Hydroxy-3- (3-hydroxymethyl-6-methoxyquinolin- 4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)- propyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-hydroxymethyl-6-methoxyquinolin- 4-yl)propyl]-1-[2-(2,4,6-trifluorophenylthio)- ethyl]piperidine-41Hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-hydroxymethyl-6-methoxyquinolin- 4-yl)propyl]-1-[2-(3,4,5-trifluorophenylthio)- ethyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-hydroxymethyl-6-methoxyquinolin- 4-yl)propyl]-!-[2-(2,4,6-trifluorophenyl- amino) ethyl]piperidine-4-hydroxainic acid 4-[3-(R,S)-Hydroxy-3-(3-hydroxymethyl-6-methoxyquinolin- 4-yl)propyl]-1-[2-(3,4,5-trifluorophenyl- amino)ethyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-hydroxymethyl-6-methoxyquinolin- 4-yl)propyl] -1- [2- (2 , 4, 6-trif luorophenoxy) -et]riyl]piperidine-4-liydroxamic acid 4- [3- (R,S) -Hydroxy-3- (3-]iydroxymethyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (3 , 4, 5-trif luoroptienoxy) -et]riyl]piperidine-4-liydroxaniic acid 4- [3- (R, S) -Hydroxy-3- (3-liydroxyinetliyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (2, 4, 6-trif luorop]ienyl)prop-2-ynyl] -piperidine-4-liydroxainic acid 4- [3- {R,S) -Hydroxy-3- (3-]iydroxyinet]iyl-6-methoxyquinolin-4-yl)propyl] -1- [3- (3, 4, 5-trif luorophenyl)prop-2-ynyl] -piperidine-4-liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-f luorometilyl-6-met]lOxyquinolin-4-yl)propyl] -1- [3- (2, 4, 6-trif luorophenyl)propyl]piperidine-4-liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-f luoromethyl-6-met]loxyquinolin-4-yl)propyl] -1- [3- (3 , 4, 5-trif luorophenyl)propyl]piperidine-4-liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-f luoromethyl-6-methoxyquinolin-4-yDpropyl] -1- [2- (2,4, 6-trif luorophenylthio) ethyl] -piperidine-4-liydroxamic acid 4- [3- (R, S) -Hydroxy"-3- (3-f luoroInetllyl-6-metllOxyquinolin-4-yl)propyl] -1- [2- (3, 4, 5-trif luorophenyltliio) etliyl] -piperidine-4-liydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-f luoroxnet]iyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (2, 4, 6-trif luorophenylamino) ethyl] -piperidine-4-hydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-f luorometliyl-6-inetlioxyquinolin-4- yl)propyl]-1-[2-(3,4,5-trifluorophenylamino)ethyl]-piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenoxy)ethyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)prop-2-ynyl]-piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2- 4,6-trifluorophenyl)propyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)propyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-aminomethyl-6-methoxyquinolin-4-yDpropyl] -1- [2- (2,4, 6-trif luorophenyl thio) ethyl] -piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenylthio)ethyl]-piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-aminomethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,4,6-trifluorophenylamino)ethyl]- piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-aminomethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,4,5-trifluorophenylamino)ethyl]- piperidine-4-hydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-axninomethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,4,6-trifluorophenoxy)ethyl]piperidine- 4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-aminomethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine- 4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-aminomethyl-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]- piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-aminomethyl-6-methoxyquinolin-4- yl)propyl]-1-[3-(3,4,5-trifluorophenyl)prop-2-ynyl]- piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-morpholinomethyl-6-methoxy- quinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)- propyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-morpholinomethyl-6-methoxy- quinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)- propyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-morpholinomethyl-6-methoxy- quinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenylthio)- ethyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-morpholinomethyl-6-methoxy- quinolin-4-yl)propyl]-1-[2-{3,4,5-trifluorophenylthio)- ethyl]piperidine-4-liydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-morpholinomethyl-6-methoxy- quinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenyl- amino)ethyl]piperidine-4-hydroxamic acid 4- [3- (R, S) -Hydroxy-3- (3-morpholinomethyl-6-methoxy- quinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenyl- amino)ethyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-morpholinomethyl-6-methoxy- quinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenoxy)- ethyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-morpholinomethyl-6-methoxy- quinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenoxy)- ethyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-morpholinomethyl-6-methoxy- quinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)prop-2- ynyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Hydroxy-3-(3-morpholinomethyl-6-methoxy- quinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)prop-2- ynyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-l-heptylpiperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[4-phenylbutyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[3-(pheny1)propyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl] -1- [4- (2-f luorophenyl) propyl J piperiaine-4i- hydroxamic acid 4-[3-(R,S)-Fluoro-3-{3-chloro-6-methoxyquinolin-4-yl)- propyl] -1- [4- (3-f luoropJienyl)propyl]piperidine-4- liydroxainic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- (3- {4-f luorophenyl)propyl]piperidine-4- liydroxamic acid 4- [3- (R, S) -Fluoro-3- {3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [4- (4-f luorophenyl)butyl]piperidine-4- hydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl]-1-[3-(2,3-difluorophenyl)propyl]piperidine-4- hydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [4- (2 , 3-dif luorop]ienyl)propyl]piperidine-4- liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-mettioxyquinolin-4-yl) - propyl]-1-[3-(2,6-difluorophenyl)propyl]piperidine-4- hydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl]-1-[4-(2,6-difluorophenyl)propyl]piperidine-4- hydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-metlaoxyquinolin-4-yl) - propyl]-1-[3-(3,5-difluorophenyl)propyl]piperidine-4- liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-inet]ioxyquinolin-4-yl) - propyl] -1- [3- (2, 3 , 5-trif luorophenyl) propyl] piper idine-4- liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [3- (2, 4, 6 - tr i f luorophenyl) propyl] piper idine-4- liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-raetli.oxyquinolin-4-yl) - propyl] -1- [3- (3, 4, 5-trif luorophenyl) propyl] piper idine-4- hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[3-phenylthiopropyl]piperidine-4-hydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl]-1-[3-(2-fluorophenylthio)propyl]piperidine-4- hydroxamic acid 4-[3-(R;S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[3-(3-fluorophenylthio)propyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(4-fluorophenylthio)ethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[3-(4-fluorophenylthio)propyl]piperidine-4- hydroxamic acid 4-[3-(R/S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(2,3-difluorophenylthio)ethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[3-(2,3-difluorophenylthio)propyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(2,6-difluorophenylthio)ethyl]piperidine-4- hydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl]-1-[2-(2,3,5-trifluorophenylthio)ethyl]piperidine- 4-hydroxainic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(2,4,6-trifluorophenylthio)ethyl]piperidine- 4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(3,4,5-trifluorophenylthio)ethyl]piperidine- 4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(3,5-difluorophenoxy)ethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(2,3,5-trifluorophenoxy)ethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(2,4,6-trifluorophenoxy)ethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl] -1- [2- (3, 5-dif luorophenylamino) etliyl] piperidine-4- tiydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-inet]aoxyquinolin-4-yl) - propyl] -1- [2- (2, 3 , 5-trif luorophenylamino) ethyl] - piperidine-4-hydroxamic acid 4- [3- (R, S) -Fluoro-3- {3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [2- (2, 4, 6-trif luoroptienylamino) ethyl] - piperidine-4-hydroxainic acid 4-[3-(R,S)-Fluoro-3-{3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(3,4,5-trifluorophenylamino)ethyl]- piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[3-(2,6-difluorophenylthio)propyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Fluoro-3-{3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(2-chlorophenylthio)ethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3°Chloro-6-methoxyquinolin-4-yl)- propyl]-1-[3-(2-chlorophenylthio)propyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(3-chlorophenylthio)ethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[3-(3-chlorophenylthio)propyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(4-chlorophenylthio)ethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl] -1- [3- {4-chlorophenyltliio)propyl]piperidine-4- tiydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-inet]ioxyquinolin-4-yl) - propyl] -1- [2- (2-methylphenyltliio) et]iyl]piperidine-4- tiydroxamic acid 4- [3- (R, S) -Fluoro-3- {3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [3- (2-metliylphenyltliio)propyl]piperidine-4- liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [2- (3-metliylphenyltliio) etliyl]piperidine-4- ]iydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-c]aloro-6-methoxyquinolin-4-yl) - propyl] -1- [3- (3-metliylphenyltliio)propyl]piperidine-4- liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [2- (4-metliylpJienylthio) etliyl]piperidine-4- liy dr oxami c acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-metl:ioxyquinolin-4-yl) - propyl] -1- [3- (4-metliylp]ienyltliio)propyl]piperidine-4- tiydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [2- (2-trif luorometliylplaenyltliio) etliyl] - piperidine-4-liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [3- (2-trifluoromethylp]ienyltliio)propyl] - piperidine~4-]iydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [2- (3-trif luorometliylphenylthio) ethyl] - piperidine~4-]iydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [3- (3-trif luorometliylp]ienylt]iio)propyl] - piperidine-4-liydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl] -1- [2- (4-trif luorometliylphenylthio) ethyl] - piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[3-(4-trifluoromethylphenylthio)propyl]- piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(2-methoxyphenylthio)ethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[3-(2-methoxyphenylthio)propyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(3-methoxyphenylthio)ethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[3-(3-methoxypheny1thio)propyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl] -1- [2- (4-inetlaoxyphenyltliio) ethyl]piperidine-4- hydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [3- (4-methoxyphenyltliio)propyl]piperidine-4- liydroxamic acid 4- [3- (R/ S) -Fluoro-3- (3-chloro-6-inetlioxyquinolin-4-yl) - propyl] -1- [eyelopentylmet]iyl]piperidine-4-liydroxamic acid 4- [3- (R, S) -Fluoro-3- {3-chloro-6-inetlioxyquinolin-4-yl) - propyl] -1- [2- (cyclopentyl) etliyl] piper idine-4-hydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [2- (cyclohexyl) et]iyl]piperidine-4-]iydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [2- (cyclopentyltliio) ethyl]piperidine-4- liydroxamic acid 4- [3- (R, S) -Fluoro-3- {3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [3- (cyclopentyl tJiio) propyl] piper idine-4- hydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl]-1-[3-(cyclohexylthio)propyl]piperidine-4- liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [2- (pyrid-2-yl) ttiioetliyl]piperidine-4- liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [4- (t]iien-2-yl) butyl]piperidine-4-liydroxamic acid 4- [3- (R, S) -Fluoro-3- {3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [3- (thien-2-yl) t]iiopropyl]piperidine-4- liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-inet]ioxyquinolin-4-yl) - propyl] -1- [3- (t]iien-3-yl)propyl]piperidine-4-liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl]-1-[4-(thien-3-yl)butyl]piperidine-4-hydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [2- (thien-2-yl) tliioethyl]piperidine-4- hydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-inetlioxyquinolin-4-yl) - propyl] -1- [2- (thien-3-yl) tliioetliyl]piperidine-4- liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [3- (thien-3-yl) t]iiopropyl]piperidine-4- hydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl]-1-[3-(1,3-thiazol-2-yl)propyl]piperidine-4- liydroxamic acid 4- [3- (R, S) -Fluoro-3- {3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [4- (1, 3-t]iiazol-2-yl)butyl]piperidine-4- liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [3- (1, 3-t]iiazol-2-yl) thioethyl]piperidine-4- liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-5-methoxyquinolin-4-yl) - propyl] -1- [3- (pyrid-2-yl)propyl]piperidine-4-laydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl]-1-[4-(pyrid-2-yl)butyl]piperidine-4-hydroxainic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl]-1-[3-(pyrid-2-yl)thiopropyl]piperidine-4- liydroxamic acid 4- [3- (R, S) -Fluoro-3- {3-c]aloro-6-methoxyquinolin-4-yl) - propyl] -1- [3- (pyrid-3-yl)propyl]piperidine-4-liydroxamic acid 4- [3- {R, S) -Fluoro-3- (3-claloro-6-inetlioxyquinolin-4-yl) - propyl] -1- [4- {pyrid-3-yl)butyl]piperidine-4-liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [2- (pyrid-3-yl) thioet]iyl]piperidine-4- liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-inetl:ioxyquinolin-4-yl) - propyl] -1- [3- {pyrid-3-yl) thiopropyl]piperidine-4- liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [3- {pyrid-4-yl)propyl]piperidine-4-laydroxamic acid 4-[3-(R,S)-Fluoro-3-{3-chloro-6-methoxyquinolin-4-yl)- propyl] -1- [4- (pyrid-4-yl)butyl]piperidine-4-liydroxamic acid 4- [3- (R, S) -Fluoro-3- {3-chloro-6-methoxyquinolin-4-yl) -propyl] -1- [2- (pyrid-4-yl) t]iioethyl]piperidine-4-Jiydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-inetlioxyquinolin-4-yl) -propyl] -1- [3- (pyrid-4-yl) thiopropyl] piperidine-4-liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) -propyl]-1-[3-(pyrazin-2-yl)propyl]piperidine-4-]iydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-inet]ioxyquinolin-4-yl) -propyl] -1- [4- (pyrazin-2-yl)butyl]piperidine-4-liydroxainic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) -propyl] -1- [2- (pyra2in-2-yl) tliioet]iyl]piperidine-4-tiydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) -propyl] -1- [3- (pyra2in-2-yl) thiopropyl]piperidine-4-hydroxamic acid 4- [3- (R, S) -Fluoro-3- {3-chloro-6-mettioxyquinolin-4-yl) -propyl] -1- [3- (4-f luorop]aenyl)prop-2-ynyl]piperidine-4-llydr oxami c acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) -propyl] -1- [3- (3 , 4-dif luorop]lenyl)prop-2-ynyl]piperidine-4 -tiydroxamic ac id 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) -propyl] -1- [3- (2 , 4-dif luorop]ienyl)prop-2-ynyl]piperidine- 4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]- piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl] -1- [3- (2, 4, 6-trif luorophenyl)prop-2-ynyl] - piperidine-4-liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [3- (3, 4, 5-trif luorophenyl)prop-2-ynyl] - piperidine-4-liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [3- (4-chloro-3-f luorophenyl)prop-2-ynyl] - piperidine-4-]iydroxamic acid 4- [3- (R, S) -Fluoro-3- {3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [3- (3-chloro-4-f luorophenyl)prop-2-ynyl] - piperidine-4-laydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-met]:ioxyquinolin-4-yl) - propyl] -1- [3- (2-chloro-4-f luorophenyl)prop-2-ynyl] - piperidine-4-liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) - propyl] -1- [3- (3-chloro-5-f luorophenyl)prop-2-ynyl] - piperidine-4-hydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-ctiloro-6-inet]ioxyquinolin-4-yl) - propyl] -1- [3- {4-chloro-2-f luorophenyl)prop-2-ynyl] - piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-[3-(3-fluoro-4-methylphenyl)prop-2-ynyl]- piperidine-4-tiydroxamic acid 4- [3- (R, S) -Fluoro-3- {3-chloro-6-methoxyquinolin-4-yl) -propyl] -1- [3- (3 , 5-bistrif luoroInetllylpllenyl)prop-2-ynyl]piperidine-4-hydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) -propyl] -1- [3- (t]iien-2-yl)prop-2-ynyl]piperidine-4-hydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) -propyl] -1- [3- (thien-3-yl)prop-2-ynyl]piperidine-4-liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) -propyl]-1-[3-(1,3-tliiazol-2-yl)prop-2-ynyl]piperidine-4-hydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-inetlioxyquinolin-4-yl) -propyl] -1- [3- (1, 3-tliiazol-4-yl)prop-2-ynyl]piperidine-4-]iydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-inet]ioxyquinolin-4-yl) -propyl]-1-[3-(1,3-thiazol-5-yl)prop-2-ynyl]piperidine-4-liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) -propyl]-1-[3-(pyrid-2-yl)prop-2-ynyl]piperidine-4-liydroxamic acid 4- [3- (R, S) -Fluoro-3- {3-chloro-6-methoxyquinolin-4-yl) -propyl]-1-[3-(pyrid-3-yl)prop-2-ynyl]piperidine-4-liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-chloro-6-methoxyquinolin-4-yl) -propyl]-1-[3-(pyrid-4-yl)prop-2-ynyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Fluoro-3-{3-methyl-6-methoxyquinolin-4-yl)- propyl]-1-[2-(cyclohexyl)ethyl]piperidine-4-hydroxamic acid 4-[3-(R, S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4-yl)- propyl]-!-[3-(phenyl)propyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4-yl)- propyl]-1-[3-(2,3,5-trifluorophenyl)propyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4-yl)- propyl]-1-[2-(3,5-difluorophenylamino)ethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4-yl)- propyl]-1-[2-(2,3,5-trifluorophenylamino)ethyl]- piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4-yl)- propyl]-1-[2-(3,5-difluorophenoxy)ethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4-yl)- propyl]-1-[2-(2,3,5-trifluorophenoxy)ethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4-yl)- propyl]-1-[2-(2,3,5-trifluorophenylthio)ethyl]piperidine- 4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4-yl)- propyl]-1-[2-(cyclopentylthio)ethyl]piperidine-4- hydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-methyl-6-methoxyquinolin-4-yl) - propyl] -1- [2- (pyrid-2-yl) thioet]iyl]piperidine-4- liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-xnetliyl-6-methoxyquinolin-4-yl) - propyl] -1- [2- (thien-2-yl) tliioetliyl]piperidine-4- liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-met]iyl-6-methoxyquinolin-4-yl) - propyl] -1- [3- (2, 3, 5-trif luorop]ienyl)prop-2-ynyl] - piperidine-4-tiydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-met]iyl-6-methoxyq[uinolin-4-yl) - propyl] -1- [3- (thien-2-yl)prop-2-ynyl]piperidine-4- liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-f luoro-6-met]:ioxyquinolin-4-yl) - propyl] -1- [2- (cyclohexyl) ethyl]piperidine-4-liydroxainic acid 4- [3- (R, S) -Fluoro-3- (3-f luoro-6-iuethoxyquinolin-4-yl) - propyl]-1-[3-(phenyl)propyl]piperidine-41Hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)- propyl]-1-[3-(2,3,5-trifluorophenyl)propyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(3,5-difluorophenylamino)ethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(2,3,5-trifluorophenylamino)ethyl]- piperidine-4-hydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-f luoro-6-methoxyquinolin-4-yl) - propyl] -l-[Z- (3 , b-airiuoropnenoxy; eT-nyxjpiptixiuxiitj-'i- tiydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-f luoro-6-methoxyquinolin-4-yl) - propyl] -1- [2- (2, 3, 5-trif luorophenoxy) etliyl]piperidine-4- laydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-f luoro-6-methoxyquinolin-4-yl) - propyl] -1- [2- (2 , 3 , 5-trif luorophenyltliio) ethyl ] piper idine- 4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(cyclopentylthio)ethyl]piperidine-4- hydroxainic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(pyrid-2-yl)thioethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(thien-2-yl)thioethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)- propyl]-1-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]- piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)- propyl]-1-[3-(thien-2-yl)prop-2-ynyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-dimethylamino-6-methoxyquinolin-4- yl)propyl]-1-[2-(cyclohexyl)ethyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-dimethylamino-6-methoxyquinolin-4- yl) propyl ] -1- [ 3 - (phenyl) propyl ] piper idine-4-liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-dimetliylainino-6-methoxyquinolin-4- yl)propyl] -1- [3- (2, 3, 5-trif luorophenyl)propyl]piperidine- 4-liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-dimet]iylamino-6-methoxyquinolin-4- yl)propyl] -1- [2- (3 , 5-dif luorophenylamino) ethyl] - piper idine-4-liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-dimethylamino-6-methoxyquinolin-4- yl)propyl] -1- [2- (2 , 3, 5-trif luorophenylamino) etliyl] - piperidine-4-liydroxainic acid 4-[3-(R,S)-Fluoro-3-(3-dimetliylamino-6-methoxyquinolin-4- yl) propyl] -1- [2- (3, 5-dif luoropiienoxy) ethyl ] piper idine-4- hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-dimethylamino-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,3,5-trifluorophenoxy)ethyl]piperidine- 4-hydroxainic acid 4-[3-(R,S)-Fluoro-3-(3-dimethylamino-6-methoxyquinolin-4- yDpropyl] -1- [2- (2,3, 5-trif luorophenylthio) ethyl] - piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-dimethylamino-6-methoxyquinolin-4- yl)propyl]-1-[2-(cyclopentylthio)ethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-dimethylamino-6-methoxyquinolin-4- yl)propyl]-1-[2-(pyrid-2-yl)thioethyl]piperidine-4- hydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-dimethylainino-6-methoxyquinolin-4- yDpropyl] -1- [2- {thien-2-yl) tliioetliylJpiperidine-4- hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-dimethylamino-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]- piperidine-4-liydroxainic acid 4- [3- (R, S) -Fluoro-3- (3-diinetliylaniino-6-methoxyquinolin-4- yl)propyl]-1-[3-(thien-2-yl)prop-2-ynyl]piperidine-4- hydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-liydroxymethyl-6-methoxyquinolin-4- yDpropyl] -1- [2- (cyclohexyl) etliyl]piperidine-4-hydroxainic acid 4- [3- (R, S) -Fluoro-3- {3-]iydroxyinetliyl-6-methoxyc[uinolin-4- yDpropyl] -1- [3- (phenyl)propyl]piperidine-4-]iydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-hydroxyinethyl-6-inetlioxyquinolin-4- yl)propyl]-1-[3-(2,3,5-trifluorophenyl)propyl]piperidine- 4-hydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-liydroxyinetliyl-6-methoxyquinolin-4- yl)propyl] -1- [2- (3, 5-dif luorophenylamino) etliyl] - piperidine-4-tiydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-hydroxymethyl-6-methoxyquinolin-4- yl)propyl] -1- [2- (2, 3, 5-trif luorophenylamino) etliyl] - piperidine-4-hydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-]iydroxymethyl-6-methoxyquinolin-4- yl)propyl] -1- [2- (3 , 5-dif luorophenoxy) et]iyl]piperidine-4- liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-]iydroxymetliyl-6-methoxyquinolin-4- 4-[3-(R,S yl)propyl yl) propyl] -1- [2- (2,3, 5-trif luoroptienoxy) etliyl]piperidine-4-]iydroxarnic acid -Fluoro-3- (3-liydroxymet]iyl-6-methoxyquinolin-4--1- [2- (2 , 3 , 5-trif luorophenylthio) etliyl] - piperidine-4-hydroxamic acid 4-[3-(R,S yl)propyl -Fluoro-3- (3-liydroxymethyl-6-methoxyquinolin-4--1- [2- (cyclopentyltliio) ethyl]piperidine-4- hydroxamic acid 4-[3-(R,S yl)propyl -Fluoro-3-(3-hydroxymethyl-6-methoxyquinolin-4--1-[2-(pyrid-2-yl)thioethyl]piperidine-4- laydroxamic acid 4-[3-(R,S y1)propyl -Fluoro-3-(3-hydroxymethyl-6-methoxyquinolin-4--1-[2-(thien-2-yl)thioethyl]piperidine-4~ tiydroxaiuic acid 4-[3-(R,S y1)propyl -Fluoro-3-(3-hydroxymethyl-6"methoxyquinolin-4--1-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]- piperidine-4-hydroxamic acid 4-[3-{R,S yl)propyl -Fluoro-3-(3-hydroxymethyl-6-methoxyquinolin-4--1-[3-(thien-2-yl)prop-2-ynyl]piperidine-4- liydroxamic acid 4-[3-{R,S yl)propyl -Fluoro-3- (3-f luoromethyl-6-raethoxyquinolin-4--l- [2- (cyclohexyl) ethyl]piperidine-4-hydroxamic acid 4-[3-{R,S -Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4- yl)propyl] -1- [3- (phenyl)propyl]piperidine-4-hydroxainic acid 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyguinolin-4- yDpropyl] -1- [3- (2,3, 5-trif luorophenyl)propyl]piperidine-4-hydroxainic acid 4- [3- (R, S) -Fluoro-3- (3-f luoromet]iyl-6-inetlioxyquinolin-4-yDpropyl] -1- [2- (3 , 5-dif luorophenylamino) etliyl] -piperidine-4-hydroxainic acid 4- [3- (R, S) -Fluoro-3- (3-f luoroinet]iyl-6-methoxyquinolin-4-yl)propyl] -1- [2- (2 , 3 , 5-trif luorop]ienylamino) etliyl] -piperidine-4-liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-f luoroI-et]lyl-6-metlloxyquinolin-4-yl)propyl] -1- [2- (3 , 5-dif luorophenoxyl) etliyl] piperidine-4-liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-f luoromethyl-6-Inet]loxyquinolin-4-yl)propyl] -1- [2- (2,3, 5-trif luorophenoxy) ethyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4-yDpropyl] -1- [2- (2,3, 5-trif luorophenylthio) ethyl] -piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(cyclopentylthio)ethyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl] -1-[2-(pyrid-2-yl)thioethyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4-yDpropyl] -1- [2- (thien-2-yl) thioethyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4- yl)propyl] -1- [3- (2, 3 , 5-trif luorop]ienyl)prop-2-ynyl] - piperidine-4-]iydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-f luoromet]iyl-6-methoxyquinolin-4- yDpropyl] -1- [3- (t]iien-2-yl)prop-2-ynyl]piperidine-4- tiydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-aminomethyl-6-methoxyquinolin-4- yl) propyl] -1- [2- (cyclohexyl) etliyl]piperidine-4-hydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-aininomet]iyl-6-methoxyquinolin-4- yl)propyl] -1- [3- (phenyl)propyl]piperidine-4-liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-aininomet]iyl-6-methoxyquinolin-4- yDpropyl] -1- [3- (2,3, 5-trif luorophenyl)propyl]piperidine- 4-liydroxainic acid 4- [3- (R, S) -Fluoro-3- (3-aminometliyl-6-met]aoxyquinolin-4- yl)propyl] -1- [2- (3 , 5-dif luorophenylamino) etJnyl] - piperidine-4-liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-aminomethyl-6-methoxyquinolin-4- yl)propyl] -1- [2- (2, 3, 5-trif luorophenylamino) ethyl] - piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-aminomethyl-6-methoxyquinolin-4- yDpropyl] -1- [2- (3 , 5-dif luorophenoxy) ethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-aininomethyl-6-methoxyquinolin-4- yDpropyl] -1- [2- (2,3, 5-trif luorophenoxy) ethyl ]piperidine- 4-hydroxainic acid 4-[3-(R,S)-Fluoro-3-(3-aininomethyl-6-methoxyquinolin-4- yl) propyl] -1- [2- (2,3, 5-trif luorophenyltliio) etliyl] - piperidine-4-]iydroxamic acid 4- [3- (R, S) -Fluoro-3- {3-aminomethyl-6-methoxyquinolin-4- yl)propyl] -1- [2- (cyclopentylthio) etliyl]piperidine-4- liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-aminometliyl-6-inetlioxyquinolin-4- yl)propyl] -1- [2- (pyrid-2-yl) tliioet]iyl]piperidine-4- tiydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-aininoinetliyl-6-methoxyquinolin-4- yl)propyl] -1- [2- (thien-2-yl) tliioethyl]piperidine-4- tiydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-aminomet]iyl-6-methoxyquinolin-4- yl)propyl] -1- [3- (2 , 3 , 5-trif luorophenyl)prop-2-ynyl] - piperidine-4-liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-aininomet]iyl-6-methoxyquinolin-4- yDpropyl] -1- [3- (thien-2-yl)prop-2-ynyl]piperidine-4- liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-morp]iolinomethyl-6-methoxy- quinolin-4-yl)propyl] -1- [2- (cyclohexyl) ethyl]piperidine- 4-hydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-morpholinomethyl-6-methoxy- quinolin-4-yl)propyl]-1-[3-(phenyl)propyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-morpholinomethyl-6-methoxy- quinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)- propyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-morpholinomethyl-6-methoxy- quinolin-4-yl)propyl] -1- [2- (3 , 5-dif luorop]ienylamino) - ethyl]piperidine-4-hydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-inorp]iolinometliyl-6-methoxy- quinolin-4-yl)propyl]-1-[2-(2,3,S-trifluorophenyl- araino) et]iyl]piperidine-4-liydroxainic acid 4- [3- (R, S) -Fluoro-3- (3-morpholinoinet]iyl-6-n\etlioxy- quinolin-4-yl)propyl] -1- [2- (3, 5-dif luorophenoxy) - et3iyl]piperidine-4-liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-morp]iolinomethyl-6-methoxy- quinolin-4-yl) propyl] -1- [2- (2 , 3, 5-trif luorophenoxy) - ethyl]piperidine-4-]iydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-inorpliolinomethyl-6-methoxy- quinolin-4-yl)propyl] -1- [2- (2,3, 5-trif luoropJienyl- tliio) etliyl]piperidine-4-liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-morpliolinomet]iyl-6-met]nioxy- quinolin-4-yl)propyl] -1- [2- (cyclopentyltliio) etliyl] - piperidine-4-liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-morp]iolinometliyl-6-inet]aoxy- quinolin-4-yl)propyl] -1- [2- (pyrid-2-yl) tliioetliyl] - piperidine-4-hydroxainic acid 4- [3- (R, S) -Fluoro-3- (3-inorp]iolinomethyl-6-methoxy- quinolin-4-yl)propyl] -1- [2- (thien-2-yl) tliioetliyl] - piperidine-4-]iydroxainic acid 4- [3- (R, S) -Fluoro-3- (3-morpholinometliyl-6-methoxy- quinolin-4-yl)propyl] -1- [3- (2, 3 , 5-trif luorophenyl)prop-2- ynyl]piperidine"4-]iydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-morptiolinometliyl-6-inetlioxy- quinolin-4-yl)propyl] -1- [3- (thien-2-yl)prop-2-ynyl] - piper idine-4-liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-metliyl-6-methoxyquinolin-4-yl) - propyl]-1-[3-(2,4,6-trifluorophenyl)propyl]piperidine-4- hydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-inet]iyl-6-methoxyquinolin-4-yl) - propyl]-1-[3-(3,4,5-trifluorophenyl)propyl]piperidine-4- liydroxamic acid 4-[3-(R, S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4-yl)- propyl] -1- [2- (2, 4, 6-trif luorophenyl tliio) ethyl ] piperidine- 4-hydroxainic acid 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4-yl)- propyl]-1-[2-(3,4,5-trifluorophenylthio)ethyl]piperidine- 4-hydroxainic acid 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4-yl)- propyl]-1-[2-(2,4,6-trifluorophenylamino)ethyl]- piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4-yl)- propyl]-1-[2-(3,4,5-trifluorophenylamino)ethyl]- piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4-yl)- propyl]-1-[2-(2,4,6-trifluorophenoxy)ethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4-yl)- propyl]-1-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4-yl)- propyl]-1-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]- piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-methyl-6-methoxyquinolin-4-yl)- propyl]-1-[3-(3,4,5-trifluorophenyl)prop-2-ynyl]- piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)- propyl]-1-[3-(2,4,6-trifluorophenyl)propyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)- propyl]-1-[3-(3,4,5-trifluorophenyl)propyl]piperidine-4- hydroxaxnic acid 4- [3- (R, S) -Fluoro-3- (3-f luoro-6-]:nethoxyquinolin-4-yl) - propyl]-1-[2-(2,4,6-trifluorophenylthio)ethyl]piperidine- 4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(3,4,5-trifluorophenylthio)ethyl]piperidine- 4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(2,4,6-trifluorophenylamino)ethyl]- piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(3,4,5-trifluorophenylamino)ethyl]- piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)- propyl]-1-[2-(2,4,6-trifluorophenoxy)ethyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)- propyl] -1- [2- (3 , 4, 5-trif luorophenoxy) ethyl ] piper idine-4- hydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-f luoro-6-methoxyquinolin-4-yl) - propyl] -1- [3- (2, 4, 6-trif luorophenyl) prop-2-ynyl] - piper idine-4-liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-f luoro-6-methoxyquinolin-4-yl) - propyl] -1- [3- (3 , 4, 5-trif luorophenyl) prop-2-ynyl] - piper idine-4-liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-dimet]iylamino-6-methoxyquinolin-4- yl) propyl] -1- [3- (2, 4, 6-trifluorophenyl) propyl] piper idine- 4-liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-dimetliylamino-6-methoxyquinolin-4- yl)propyl] -1- [3- (3 , 4, 5-trif luorophenyl) propyl]piperidine- 4-liydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-dimetliylamino-6-methoxyquinolin-4- yl)propyl] -1- [2- (2, 4, 6-trif luorophenylthio) ethyl] - piperidine-4-hydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-dimet]iylamino-6-methoxyquinolin-4- yl) propyl] -1- [2- (3 , 4, 5-trif luorophenyl tliio) etliyl] - piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-dimethylamino-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,4,6-trifluorophenylamino)ethyl]- piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-dimethylamino-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,4,5-trifluorophenylamino)ethyl]- piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-dimethylamino-6-methoxyquinolin-4- yl) propyl] -1- [2- (2,4, 6-trif luorophenoxy) ethyl]piperidine- 4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-dimethylamino-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine- 4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-dimethylamino-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]- piperidine-4-hydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-dimethylamino-6-methoxyquinolin-4- yl)propyl]-1-[3-(3,4,5-trifluorophenyl)prop-2-ynyl]- piperidine-4-hydroxainic acid 4-[3-(R,S)-Fluoro-3-(3-fluoro-6-methoxyquinolin-4-yl)- propyl]-1-[3-(2,4,6-trifluorophenyl)propyl]piperidine-4- hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-hydroxyTnethyl-6-methoxyquinolin-4- yl)propyl]-1-[3-(3,4,5-trifluorophenyl)propyl]piperidine- 4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-hydroxymethyl-6-methoxyquinolin-4- yDpropyl] -1- [2- (2, 4, 6-trif luorophenylthio) ethyl] - piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-hydroxymethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,4,5-trifluorophenylthio)ethyl]- piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-hydroxymethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,4,6-trifluorophenylamino)ethyl]- piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-hydroxymethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,4,5-trifluorophenylamino)ethyl]- piperidine-4-hydroxainic acid 4- [3- (R, S) -Fluoro-3- (3-hydroxymethyl-6-methoxyquinolin-4- yDpropyl] -1- [2- (2, 4, 6-trifluorophenoxy) ethyl]piperidine- 4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-hydroxyTnethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine- 4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-hydroxymethyl-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]- piperidine-4-hydroxainic acid 4- [3- (R, S) -Fluoro-3- (3-hydroxymethyl-6-methoxyquinolin-4- yl)propyl]-1-[3-(3,4,5-trifluorophenyl)prop-2-ynyl]- piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,4,5-trifluorophenyl)propyl]piperidine- 4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4- yl)propyl]-1-[3-(3,4,5-trifluorophenyl)propyl]piperidine- 4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4- yl)propyl]-l-[2-(2,4,6-trifluorophenylthio)ethyl]- piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,4,5-trifluorophenylthio)ethyl]- piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4- yDpropyl] -1- [2- (2, 4, 6-trif luorophenylamino) ethyl] -piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-{3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenylamino)ethyl]-piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4-yDpropyl] -1- [2- (2,4, 6-trif luorophenoxy) ethyl] piper idine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl] -1-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]-piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-fluoromethyl-6-methoxyquinolin-4-yDpropyl] -1- [3- (3,4, 5-trif luorophenyl)prop-2-ynyl] -piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)propyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)propyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-aminomethyl-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenylthio)ethyl]-piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-aminomethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,4,5-trifluorophenylthio)ethyl]- piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-aminomethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,4,6-trifluorophenylamino)ethyl]- piperidine-4-hydroxainic acid 4-[3-(R,S)-Fluoro-3-(3-aminomethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,4,5-trifluorophenylamino)ethyl]- piperidine-4-hydroxainic acid 4-[3-(R, S)-Fluoro-3-(3-aininomethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(2,4,6-trifluorophenoxy)ethyl]piperidine- 4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-aminomethyl-6-methoxyquinolin-4- yl)propyl]-1-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine- 4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-aminomethyl-6-methoxyquinolin-4- yl)propyl]-1-[3-(2,4,6-trifluorophenyl)prop-2-ynyl]- piperidine-4-hydroxainic acid 4-[3-(R, S)-Fluoro-3-(3-aminomethyl-6-methoxyquinolin-4- yl)propyl]-1-[3-(3,4,5-trifluorophenyl)prop-2-ynyl]- piperidine-4-hydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-inorpholinomethyl-6-methoxy- quinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)- propyl]piperidine-4-hydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-inorpholinomethyl-6-methoxy- quinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)- propyl]piperidine-4-hydroxainic acid 4- [3- (R, S) -Fluoro-3- (3-morpholinomethyl-6-methoxy- quinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenylthio)- etliyl]piperidine-4-]iydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-morpholinomet]iyl-6-methoxy- quinolin-4-yl) propyl] -1- [2- (3, 4, 5-trif luorophenyltliio) - etliyl]piperidine-4-]iydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-inorp]nolinomethyl-6-met]:ioxy- quinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenyl- amino) etliyl]piperidine-4-hydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-morp]iolinomethyl-6-methoxy- quinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenyl- amino) ethyl]piperidine-4-liydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-morpholinomethyl-6-methoxy- quinolin-4-yl)propyl]-1-[2-(2,4,6-trifluorophenoxy)- ethyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-morpholinomethyl-6-methoxy- quinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenoxy)- ethyl]piperidine-4-hydroxamic acid 4-[3-(R,S)-Fluoro-3-(3-morpholinomethyl-6-methoxy- quinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)prop-2- ynyl]piperidine-4-hydroxamic acid 4- [3- (R, S) -Fluoro-3- (3-inorpholinomethyl-6-methoxy- quinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)prop-2- ynyl]piperidine-4-hydroxamic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2- fluorophenyl)allyl]piperidine-4-carboxylic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3- fluorophenyl)allyl]piperidine-4-carboxylic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[3-(4-fluorophenyl)allyl]piperidine-4-carboxylic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3-difluorophenyl)allyl]piperidine-4-carboxylic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-l-[3-(2,4-difluorophenyl)allyl]piperidine-4-carboxylic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,6-difluorophenyl)allyl]piperidine-4-carboxylic acid 4- [3- (3-Fluoro-6-Tnethoxyquinolin-4-yl)propyl] -1- [3- (3 , 5-difluorophenyl)allyl]piperidine-4-carboxylic acid 4- [3- (3-Fluoro-6-methoxyquinolin-4-yl)propyl] -1- [3- (3, 4-difluorophenyl)allyl]piperidine-4-carboxylic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,3,5-trifluorophenyl)allyl]piperidine-4-carboxylic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2 , 3 , 4-trifluorophenyl)allyl]piperidine-4-carboxylic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2 , 3 , 6-trifluorophenyl)allyl]piperidine-4-carboxylic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2 , 4 , 5-trifluorophenyl)allyl]piperidine-4-carboxylic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,4,6-trifluorophenyl)allyl]piperidine-4-carboxylic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,4,5-trifluorophenyl)allyl]piperidine-4-carboxylic acid 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[3-(3,5,6-trifluorophenyl)allyl]piperidine-4-carboxylic acid The examples which follow, given in a non- limiting manner, illustrate the present invention Exairple 1 4- [3-(3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- [2-{thien-2-y1)thioethyl]-piperidine-4-carboxy1ic acid dihydrochloride. A mixture of 0.6 g of benzyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(thien-2-yl)thioethyl]-piperidine-4-carboxylate in 7,72 cm3 of aqueous 6N hydrochloric acid is maintained at a temperature in the region of 100°C with stirring and under an inert atmosphere for 2 hours, After cooling to about 2 0°C, the reaction mixture is concentrated to dryness under reduced pressure (5 IcPa) at a temperature in the region of 40°C. The residue obtained is talcen up in 10 cm3- of a dichloromethane/methanol mixture (90/10 by volume). The mixture is concentrated to dryness under the above conditions. 0.58 g of 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(thien-2-yl)thioethyl]piperidine-4-carboxylic acid dihydrochloride, is obtained in the form of a beige-colored foam melting at 130°C with decomposition - 1H 3SIMR spectrum (250 MHz, (CD3)2SO-d6 at a temperature of 373 K, 6 in ppm) : from 1.50 to 2.30 (mts: 8H in total); from 2.70 to 3.80 (mts: lOH in total); 3.99 (s: 3H); 7,09 (dd, J = 5 and 3.5 Hz: 1H); 7.29 (broad d, J = 3.5 Hz: 1H); 7.40 (d, J = 2.5 Hz: 1H); 7.46 (dd, J = 9 and 2.5 Hz: 1H); 7.64 (broad d, J = 5 Hz: 1H); 7.99 (d, J = 9 Hz: 1H); 8.67 (s: 1H). Benzyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2- {thien-2-yl) thioethyl] -piperidine-4--carboxylate A mixture of 0.6 g of benzyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate, 0.36 g of 2-(2-bromoethylthio)thiophene and 0.22 g of potassium carbonate in 20 cm3 of acetonitrile is heated for 16 hours at a temperature in the region of 80°C, with stirring and under an inert atmosphere. After cooling to a temperature in the region of 20°C, the reaction mixture is concentrated under reduced pressure (5 kPa) at a temperature in the region of 40°C. A residue is obtained, which is purified by chromatography, under a nitrogen pressure of 100 kPa, on a column of silica gel (particle size 40-63 |i; diameter 3.5 cm; height 28 cm), eluting with a mixture of dichloromethane/methanol (97.5/2.5 by volume) and collecting 35-cm3 fractions. Fractions 15 to 2 0 are combined and then concentrated to dryness under the above conditions. 0.67 g of benzyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(thien-2-yl)thio-ethyl]piperidine-4-carboxylate is obtained in the form of an orange-colored viscous oil. Infra-red spectrum (CCI4) 2955; 1727; 1622; 1503; 1229; 1117; 833 and 698 cm3- Benzyl 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -piperidine-4-carbo3cylate. 1.27 cm3 of trifluoroacetic acid are added, with stirring and under an inert atmosphere, at a temperature in the region of 20°C, to a solution of 2.05 g of benzyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-propyl]-1-(tert-butyloxycarbonyl)piperidine-4-carboxylate in 50 cm3 of dichloromethane. After 30 minutes, a further 1.27 cm3 of trifluoroacetic acid are added and, after a further 30 minutes, a further 1.27 cm3 are added. The reaction is completed by a final addition of 1.27 cm3 of trifluoroacetic acid. After one hour, the reaction mixture is concentrated under reduced pressure (5 kPa) at a temperature in the region of 40°C. The evaporation residue is talcen up in 50 cm3 of ethyl acetate and 2 0 cm3-of water. After addition of 5 g of potassium carbonate and stirring for 5 minutes, phases are allowed to separate by settling and the organic phase separated out is washed with twice 10 cm3 of distilled water and then with 2 0 cm3 of aqueous 10% (by weight) sodium chloride solution. After drying over magnesium sulfate and then filtration, the organic solution is concentrated under reduced pressure (5 ]cPa) at a temperature in the region of 40°C. The residue obtained is purified by chromatography, under a nitrogen pressure of 100 JcPa, on a column of silica gel (particle size 40-63 \i; diameter 3.5 cm; height 30 cm), eluting with a mixture of dichloromethane/methanol/32% aqueous ammonia (89/10/1 by volume), and collecting 40-cm3- fractions. Fractions 14 to 23 are combined and then concentrated to dryness under the above conditions, 1.36 g of benzyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate are obtained in the form of a beige-colored solid melting at Infra-red spectrum (KBr) 2960; 1721; 1621; 1503; 1232; 1115; 829 and 744 cm3- Benzyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-(tert-butyloxycarbonyl)-piperidine-4-carboxylate. 1.98 g of benzyl 4-allyl-l-(tert-butyloxycarbonyl)piperidine-4-carboxylate are cooled to a temperature in the region of -30°C and 11.32 cm3- of a 0.5M solution of 9-borabicyclo[3.3.l]nonane in tetrahydrofuran are added with stirring and under an inert atmosphere. After the addition, the temperature of the mixture is brought to about 20°C. The solution obtained is stirred for a further 4 hours, followed by addition of 40 cm3 of dioxane, 0.183 g of diphenyl-phosphinoferrocenepalladium chloride, 2 g of 4-bromo-3-chloro-6-methoxyquinoline and 3.0 g of tribasic potassium phosphate. After stirring for 16 hours at a temperature in the region of 60°C, the reaction mixture is cooled to about 20°C and then filtered. The insoluble material is washed with 3 times 2 0 cm3 of ethyl acetate and the filtrate and washing waters are then combined and stirred with 40 cm3 of water and 100 cm3- of ethyl acetate. The organic phase is separated out by settling, washed with twice 20 cm3- of water and then with 40 cm3 of aqueous 10% (by weight) sodium chloride solution, dried over magnesium sulfate, filtered and concentrated under reduced pressure (5 kPa) at a temperature in the region of 40°C. The residue obtained is purified by chromatography, under a nitrogen pressure of 100 kPa, on a column of silica gel (particle size 40-63 }X; diameter 3,5 cm; height 30 cm), eluting with a mixture of dichloromethane/methanol (98.5/1.5 by volume) and collecting 35-cm3- fractions. Fractions 22 to 29 are combined and then concentrated under the above conditions. 2.09 g of benzyl 4-[3-(3-chloro-6-methoxy-guinolin-4-yl)propyl] -1-(tert-butyloxycarbonyl)-piperidine-4-carboxylate are obtained in the form of a thick yellow oil. Infra-red spectriim (CCI4) 2930; 1728; 1695; 1622; 1503; 1230; 1172; 833 and 697 cm "Benzyl 4-allyl-l-(tert-butyloxycarbonyl)piperidine-4-carboxylate * 15.4 g of potassium carbonate and then 10.6 cm3 ) of benzyl bromide are added, at a temperature in the region of 20°C, with stirring and under an inert atmosphere, to a solution of 20 g of 4-allyl-l-(tert- butyloxycarbonyl)piperidine-4-carboxylic acid in 200 civr' of dimethylformamide. The mixture is stirred for 16 hours at about 20°C and then filtered. The insoluble material is washed with twice 100 cm3 of ethyl acetate. The filtrate and the washing waters are combined, 2 50 cm3 of water are added and the mixture is then extracted once with 500 cm3 and once with 150 cm3- of ethyl acetate. The organic extracts are combined, washed with twice 125 cm3 of aqueous 10% (by weight) sodium chloride solution, dried over magnesium sulfate, filtered and concentrated under reduced pressure (5 kPa) at a temperature in the region of 40°C. An oil is obtained, which is purified by chromatography, under a pressure of 100 kPa of nitrogen, on a coluxmi of silica gel (particle size 40-63 -; diameter 7 cm; height 30 cm), eluting with a mixture of dichloromethane/methanol (99/1 by volume) and collecting 200-cm3 fractions. Fractions 6 to 16 are combined and concentrated to dryness under reduced pressure (5 kPa) at a temperature in the region of 40°C. 25 g of benzyl 4-allyl-1-(tert-butyloxycarbonyl)piperidine-4-carboxylate are obtained in the form of a pale yellow liquid. Infra-red spectrum (CH2CI2) : 2980; 1725; 1683; 1426; 1171; 1142; 974 and 924 cm3- 4-Allyl-l-(tert-butyloxycarbonyl)piperidine-4-carboxylic acid. 4.44 cm3- of water and then 30.62 g of ethyl 4- allyl-1-(tert-butyloxycarbonyl)-piperidine-4-carboxylate predissolved in 150 cm3 of tetrahydrofuran are added, with stirring and under an inert atmosphere, to a mixture of 48.52 g of potassium tert-butoxide in 350 cm3 of tetrahydrofuran, cooled to a temperature in the region of 0°C. After allowing the temperature to return to the region of 20°C, the mixture is stirred for 24 hours at this temperature. 300 cm3 of ice-cold water are added to the reaction mixture and the mixture is then concentrated to dryness under reduced pressure (5 kPa) at a temperature in the region of 40°C. The aqueous residue is extracted with 300 cm3- of diethyl ether. After leaving to stand for 16 hours, the aqueous phase is acidified at a pH in the region of 3-4 by addition of about 215 cm3- of aqueous hydrochloric acid, and is then extracted with 3 times 300 cm3- of diethyl ether. The ether extracts are combined, dried over magnesium sulfate, filtered and concentrated to dryness under reduced pressure (5 kPa) at a temperature in the region of 40°C- 26.1 g of 4-allyl-l-(tert-butyloxycarbonyl)piperidine-4-carboxylic acid are obtained in the form of an off-white solid. Mass spectrum: EI m/2=269 M"* m/z=168 (M - C5H9O2)"' m/z=124{m/z=168 - C02)- m/z = 57 C-Ks- base peak Ethyl allyl-1- (tert-butylo3°Carbonyl)pipericline-4-carboxylate. 7 0 cm3 of a solution of butyllithium in hexane (2.5M concentration) are added, with stirring and under an inert atmosphere, to 150 cm3 of tetrahydrofuran cooled to a temperature in the region of -7 0°C, followed by addition of 50 cm3 of tetrahydrofuran and 23 cm3 of diisopropylamine predissolved in 300 cm3- of tetrahydrofuran. After a further addition of 50 cm3 of tetrahydrofuran, the mixture is stirred for 15 minutes at about -70°C, followed by addition of 45.15 g of ethyl de 1-(tert-butyloxycarbonyl)isonipecotate predissolved in 400 cm3- of tetrahydrofuran, and finally 50 cm3 of this same solvent. After stirring the mixture for 1 hour at a temperature in the region of -70°C, 16.7 cm3- of allyl bromide predissolved in 150 cm3 of tetrahydrofuran are added and the mixture is then warmed to about 20°C and stirred for 17 hours. The mixture is poured into 200 cm3 of saturated aqueous ammonium chloride solution and then extracted with about 2 liters of ethyl acetate. The combined extracts are dried over sodium sulfate, filtered and concentrated under reduced pressure (5 kPa) at a temperature in the region of 40'°C. An oil is obtained, which is purified by chromatography, under a nitrogen pressure of 100 kPa, on a column of silica gel (diameter 12 cm; height 50 cm), eluting with a mixture of dichloromethane/methanol (99.5/0.5 by volume) and collecting 200-cm3 fractions. Fractions 20 to 84 are combined and concentrated under reduced pressure (5 kPa) at a temperature in the region of 40°C. 27.85 g of ethyl 4-allyl-l-(tert-butyloxycarbonyl)-piperidine-4-carboxylate are obtained in the form of a yellow oil. Mass spectrum: EI m/z=297 M""' m/z=240 (M - C4H9)"' m/z=196(m/z=240 - CO2)"' m/z=16B (m/z=240 - C02Et)' m/z = 124 (m/z = 168 - C02)-m/z=57 C4H9'" base peak Ethyl 1-(tert-butyloxycarbonyl)isonipecotate. 88.3 cm3- of triethylamine are added over 1 hour, with stirring and under an inert atmosphere, to a solution of 100 g of ethyl isonipecotate in 1500 cm3- of dichloromethane cooled to a temperature in the region of 5°C, followed, over the same time, by addition of 166.6 g of di-tert-butyl dicarbonate predissolved in 300 cm3 of dichloromethane. The reaction mixture is stirred for 16 hours while allowing the temperature to return to the region of 20°C. After a further addition of 41.6 g of di-tert-butyl dicarbonate dissolved in 70 cm3- of dichloromethane, the reaction mixture is stirred for 3 hours at about 20°C and then washed with twice 600 cm3 of saturated aqueous sodium chloride solution, dried over sodium sulfate, filtered and concentrated under reduced pressure (5 kPa) at a temperature in the region of 40°C. 171 g of ethyl 1-(tert-butyloxycarbonyl)isonipecotate are obtained in the form of a brown oil. Mass spectrum: DCI m/z=275 MNH4"' base peak m/z=258 MH' 2-(2-Bromoethylsulfanyl)thiophene may be prepared according to Sadykhov, K.I., Aliev, S.M. and Seidov, M.M. Khim. Geterotsikl. Soedin, 3, 344-5 (1975). 4-Bromo-3-chloro-6-methoxyquinoline• A mixture of 20 g of 3-chloro-4-hydroxy-6-methoxyquinoline in 1000 cm3- of acetonitrile, to which is added 80.8 g of triphenylphosphine bromide, is stirred for 2 hours 30 minutes at a temperature in the region of 85°C. The solution obtained is cooled to the region of 20°C and then stirred for 16 hours at this same temperature- The reaction mixture is concentrated under reduced pressure (5 kPa) at a temperature in the region of 40°C and the evaporation residue is then taken up in 200 cm3- of saturated aqueous sodium hydrogen carbonate solution and 200 cm3- of ethyl acetate. The organic phase is separated out after settling has taken place and is washed with twice 200 cm3 of distilled water. The aqueous phase is extracted once more with ethyl acetate and the organic extracts are then combined, dried over magnesium sulfate, filtered and concentrated under reduced pressure (5 kPa) at a temperature in the region of 40°C. A product is obtained, which is purified by chromatography under a nitrogen pressure of 100 kPa, on a column of silica gel (diameter 7.5 cm; mass of silica 700 g), eluting with a mixture of cyclohexane/ethyl acetate (70/30 by volume), The fractions corresponding to the expected product are collected. These fractions are combined and then concentrated under the same conditions as above. 20.7 g of 4-bromo-3-chloro-6-methoxyquinoline are obtained in the form of a white solid melting at 108°C. Mass spectrum: EI m/z=271 M"*"' base peak m/z=256 (M - CHa)" m/z=228 (m/z=:256 - CO)" m/z=149 (m/z=228 - Br)"- m/2=114(m/z=149 - Cl)"" 3-Chloro-4-hydroxy-6-methoxyquinoline. 14.26 g of N-chlorosuccinimide are added, at a temperature in the region of 20°C and with stirring, to a mixture of 17 g of 4-hydroxy-6-methoxyquinoline in 700 cm3 of acetic acid and the mixture is then heated at a temperature of between 50 and 70°C for 4 hours. The solution obtained is subsequently cooled to about 20°C and then concentrated to dryness under reduced pressure (5 kPa) at a temperature in the region of 40°C- The solid residue is taken up in 250 cm3 of saturated aqueous sodium hydrogen carbonate solution. The mixture is stirred for 1 hour. The insoluble material is filtered off and washed with 3 times 250 cm3 of water. The crystals obtained are dried under reduced pressure (10 Pa) for 3 hours at a temperature in the region of 20°C. 20 g of 3-chloro-4-hydroxy-6-methoxyquinoline are obtained in the form of a yellow solid. Mass spectrum: EI m/z=209 M""" base peak m/z = 194 (M - CH3)-m/z = 166 (m/z = 194 - CO)'. 4-Hydroxy-6-methoxyquinoline. A suspension of 53.5 g of 4-hydroxy-6-methoxy-quinoline-3-carboxylic acid in 1000 cm3 of diphenyl ether is heated with stirring, at a temperature of between 250°C and 260°C, for 2 hours 45 minutes. The reaction mixture is cooled to about 2 0°C. After stirring for 16 hours at this temperature, the mixture is poured with stirring into 1 liter of pentane and then filtered. The cake obtained is washed with 3 times 100 cm3- of pentane and then with 3 times 100 cm3- of diisopropyl ether. After drying in air, 37 g of 4-hydroxy-6-methoxyquinoline are obtained in the form of a beige-colored solid. Mass spectrum: DCI m/z = 176 MH"*" base peak 4-Hydroxy-6-methoxyquinoline-3-carboxylic acid can be prepared according to B.R. Baker and Ray R. Bramhall, J. Med. Chem. 15, 230 (1972). Example 2 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluorophenoxy)ethyl]piperidine-4-carboxylic acid. A mixture of 0.7 g of benzyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluorophenoxy)-ethyl]piperidine-4-carboxylate in 10 cm3 of aqueous 5M hydrochloric acid is stirred for 5 hours at a temperature in the region of lOO°C. After cooling to about 20°C, the reaction mixture is concentrated to dryness under reduced pressure (5 kPa) at a temperature in the region of 40°C. The residue obtained is purified by chromatography under a nitrogen pressure of 100 kPa, on a column of silica gel (particle size 40-63 -i; diameter 2.5 cm; height 35 cm) , eluting with a mixture of dichloromethane/methanol/28% aqueous ammonia (89/10/1 by volume) and collecting 25-cm3 fractions. Fractions 16 to 25 are collected. These fractions are combined and then concentrated under the above conditions. The evaporation residue obtained is slurried in 10 cm3 of diisopropyl ether. The resulting crystalline product is filtered off, washed with twice 5 cm3- of the same solvent and air-dried. 0.37 g of 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluorophenoxy)ethyl]piperidine-4-carboxylic acid is obtained in the form of a white solid melting at 204°C. 1H NMR spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) : from 1.20 to 2.15 (mt: lOH); 2,62 (t, J = 5.5 Hz: 2H); from 2.65 to 2.80 (mt: 2H); 3.18 (mt: 2H); 3.96 (s: 3H); 4.08 (t, J = 5.5 Hz: 2H); from 6.60 to 6.85 (mt: 3H); 7.38 (d, J = 2.5 Hz: 1H); 7.46 (dd, J = 9 and 2.5 Hz: 1H); 7.97 (d, J = 9 Hz: 1H); 8.68 (s: 1H). Benzyl 4- [3- (3-chloro-6-methoxyquinolin'-4-yl)propyl] -1-[2-(3,5-difluorophenoxy)ethyl]piperidine-4-carboxylate. A suspension composed of 1.36 g of benzyl 4-[3-{3-chloro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate, 0.95 g of 1-(2-bromoethoxy)-3,5-difluoro-benzene (90 % pure) and 0.5 g of potassium carbonate in 45 cm3 of acetonitrile is heated at a temperature in the region of 80°C for 16 hours, with stirring and under an inert atmosphere. After cooling to a temperature in the region of 20°C, the reaction mixture is filtered and the insoluble material is washed with acetonitrile. The filtrate and the washing waters are combined and concentrated under reduced pressure (5 kPa) at a temperature in the region of 40°C. The evaporation residue is purified by chromatography under a nitrogen pressure of 100 kPa, on a column of silica gel (particle size 40-63 \i; diameter 3.5 cm; height 45 cm), eluting with a mixture of dichloromethane/methanol (97/3 by volume) and collecting 40-cm3- fractions. Fractions 18 to 23 are collected. These fractions are combined and then concentrated to dryness under reduced pressure (5 kPa) at a temperature in the region of 40°C. 1-56 g of benzyl 4-[3-(3-chloro-6-methoxyguinolin-4-yl)propyl]-1-[2-(3,5-difluorophenoxy)ethyl]piperidine-4-carboxylate are obtained in the form of an orange-colored oil. Infra-red spectrum (CH2CI2) : 2955; 1723; 1622; 1599; 1229; 1153; 1116 and 843 cm3-. Benzyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate was prepared in Example 1. Example 3 4- [3- (3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- (2-cyclohexylethyl)piperidine-4-carboxyllc acid. A mixture of 0.6 g of benzyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-{2-cyclohexylethyl)-piperidine-4-carboxylate in 9.6 cm3 of aqueous 5M hydrochloric acid is heated at a temperature in the region of 100°C with stirring for 5 hours. The solution obtained is concentrated under reduced pressure (5 kPa) at a temperature in the region of 40°C. The evaporation residue obtained is slurried in diisopropyl ether. The resulting crystalline product is filtered off, washed with the same solvent and oven-dried at a temperature in the region of 60°C, under reduced pressure (10 Pa). A solid is obtained, which is purified by chromatography under a nitrogen pressure of 100 kPa, on a column of silica gel (particle size 40-63 -i; diameter 2.5 cm; height 40 cm), eluting with a mixture of dichloro-methane/methanol/32% aqpieous ammonia (89/10/1 by volume), and collecting 25-cm3 fractions. Fractions 16 to 25 are combined and then concentrated under reduced pressure (5 kPa) at a temperature in the region of 40°C. A crystalline product is obtained, which is stirred in 5 cm3 of diisopropyl ether. The product obtained is filtered off, washed with the same solvent and air-dried 0.33 g of 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-(2-cyclohexylethyl)piperidine-4-carboxylic acid is obtained in the form of a white solid melting at 234°C. IR NMR spectrum (300 MHz, CD30D-d4, 5 in ppm) : from 0-95 to 2.20 - 2.42 - from 2.90 to 3,15 and from 3.30 to 3.50 (respectively, mt, broad d, J = 13.5 Hz, mt and mt: 29H in total); 4.11 (s: 3H); 7.52 (mt: 2H); 8.02 (broad d, J = 9 Hz: 1H); 8.68 (s: 1H). Benzyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-(2-cyclohexylethyl)piperidine-4-carboxylate. 0.56 cm3 of 2-cyclohexylethyl bromide and 0.5 g of potassium carbonate are added, with stirring and under an inert atmosphere, at a temperature in the region of 20°C, to a solution of 1.36 g of benzyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate in 50 cm3 of acetonitrile. The suspension obtained is heated at about 80°C for 16 hours and, after cooling to a temperature in the region of 20°C, the reaction mixture is filtered and concentrated to dryness under reduced pressure (5 kPa) at a temperature in the region of 40°C. The residue obtained is purified by chromatography under a nitrogen pressure of 100 kPa, on a column of silica gel (particle size 40-63 |A; diameter 3.5 cm; height 45 cm). eluting with a mixture of dichloromethane/methanol (97/3 by volume) and collecting 40-cm3- fractions. Fractions 22 to 30 are combined and concentrated to dryness under reduced pressure (5 kPa) at a temperature in the region of 40°C. 1.33 g of benzyl 4-[3-(3-chloro-6-methoxy-quinolin-4-yl)propyl]-1-(2-cyclohexylethyl)piperidine-4-carboxylate are obtained in the form of an orange-colored oil. Infra-red spectrum (CCI4) : 2925; 1727; 1622; 1503; 1230; 1116; 833 and 697 cm3Benzyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-propyl]piperidine-4-carboxylate was prepared in Example 1. Example 4 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-(3-phenylpropyl)piperidine-4-carboxylic acid dihydrochloride• 0-5 g of benzyl 4-[3-(3-chloro-6-methoxy-quinolin-4-yl)propyl]-1-(3-phenylpropyl)-piperidine-4-carboxylate in 8 cm3- of 5M hydrochloric acid is heated at a temperature in the region of lOO°C, with stirring, for 5 hours. After cooling to about 20°C, the reaction mass is concentrated under reduced pressure (5 IcPa) at a temperature in the region of 40°C. The evaporation residue obtained is talcen up in 6 cm3 of a mixture of dichloromethane/methanol (90/10 by volume) and the mixture is again concentrated to dryness under the above conditions. A foam is obtained, which is slurried in 5 cm3 of diisopropyl ether. The crystalline product formed is filtered off, washed with three times 5 cm3- of the same solvent and dried in an oven under reduced pressure (10 Pa) at a temperature in the region of 50°C. 0.46 g of 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-(3-phenylpropyl)piperidine-4-carboxylic acid dihydrochloride is obtained in the form of a beige-colored solid. 1H NMR spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) from 1.40 to 2.25 and from 2.50 to 3.60 (mts: 20H in total); 3.96 (s: 3H); from 7.10 to 7.45 (mt: 5H); 7.39 (d, J = 2.5 Hz: 1H); 7.47 (dd, J = 9 and 2.5 Hz: 1H); 7.98 (d, J = 9 Hz: 1H); 8.70 (s: 1H); [lacuna] Benzyl 4-[3-{3-chloro-6-methoxyquinolin-4-yl)propyl]-1-{3-phenylpropyl)piperidine-4-carboxylate. A mixture composed of 1.36 g of benzyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate, 0.55 cm3- of l-bromo-3-phenylpropane and 0.5 g of potassium carbonate in 45 cm3 of acetonitrile is heated with stirring and under an inert atmosphere for 16 hours at a temperature in the region of 80°C. After cooling, the reaction mixture is filtered and the insoluble material is then washed with acetonitrile. The filtrate is concentrated to dryness under reduced pressure (5 kPa) at a temperature in the region of 40°C. An oil is obtained, which is purified by chromatography under a nitrogen pressure of 100 kPa, on a column of silica gel (particle size 40-63-; diameter 3.5 cm; height 3 0 cm), eluting with a mixture of dichloromethane/-methanol (97/3 by volume) and collecting 40-cm3 fractions. Fractions 21 to 25 are combined and then concentrated as above. 21 g of benzyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-(3-phenylpropyl)-piperidine-4-carboxylate are obtained in the form of an orange-colored viscous oil. Infra-red spectrum (CH2CI2) : 2948; 2812; 1722; 1622; 1504; 1229; 1118; 1029 and 834 cm~- Benzyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate was prepared in Example 1. Example 5 4- [3- (3-Chloro-6-methoxy A mixture of 0.4 g of ethyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(pyrid-2-yl)thio-ethyl]piperidine-4-carboxylate in 7 cm3 of aqueous 5M hydrochloric acid is maintained at a temperature in the region of lOO°C, with stirring and under an inert atmosphere, for 4 hours. After cooling to about 20°C, the reaction mixture is concentrated to dryness under reduced pressure (5 kPa) at a temperature in the region of 40°C, The residue obtained is taken up in 10 cm3 of a mixture of dichloromethane/methanol (90/10 by voliime) . The mixture is concentrated to dryness under the above conditions. 0.45 g of 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(pyrid-2-yl)thioethyl]piperidine-4-carboxylic acid trihydrochloride is obtained in the form of a foam melting with decomposition at 132°C. 1H NMR spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) : 1.59 (mt: 2H) ; from 1.65 to 1.95 (mt: 4H) ; 2.20 (broad d, J = 13.5 Hz: 2H); 2.86 (mt: 2H); from 3.10 to 3.65 (mt: 8H); 3.99 (s: 3H); 7.19 (broad dd, J = 7,5 and 4,5 Hz: 1H); from 7.35 to 7.50 (mt: 2H); 7.50 (dd, J = 9 and 3 Hz: 1H); 7.71 (resolved t, J = 7,5 and 1.5 Hz: 1H); 8.01 (d, J = 9 Hz: 1H); 8.48 (broad d, J = 4.5 Hz: 1H); 8.74 (s: 1H); 10.70 (multiplet: 1H). Ethyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2-pyrid-2-yl)thioethyl]plperidlne-4-carboxylate. Ethyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-propyl]-1-[2-(2-pyrid-2-yl)thioethyl]piperidine-4-carboxylate is prepared by analogy with the method described in Example 1, starting with ethyl 4-[3-(3- chloro-6-methoxyquinolin-4-yl)propyl]piperidine-4" carboxylate hydrochloride. Infra-red spectrum (CCI4) : 2955; 1726; 1622; 1580; 1503; 1414; 1229; 1125; 1030 and 833 cm3Ethyl 4- [3- (3-chloro-6-methoxy(iuinolin-4-yl)propyl] -piperidine-4-carboxylate hydrochloride. A mixture of 2.6 g of ethyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-(tert-butyloxycarbonyl)-piperidine-4-carboxylate in 40 cm3 of dioxane, to which is added 14 cm3 of 4 N hydrochloric dioxane, is stirred for 16 hours at a temperature in the region of 20°C. The suspension obtained is diluted by addition of 100 cm3 of diethyl ether, stirred at about 20°C for 1 hour and then filtered. The cake is washed with twice 40 cm3 of diethyl ether and then dried in a desiccator under reduced pressure (5 kPa). 1.9 g of ethyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate are obtained in the form of a white solid. Infra-red spectrum (KBr): 2965; 2474; 1720; 1620; 1584; 1416; 1241; 1119; 1019; 872 and 743 cm3- Ethyl 4- [3-(3-chloro-6-methoxyq:uinolin-4-yl)propyl] -1-(tert-butyloxycarbonyl) piperidiiie-4 -carboxylate. 30 cm3- of a 0. 5M solution of 9-borabicyclo-[3.3.IJnonane in tetrahydrofuran are added to a solution of 2.96 g of ethyl 4-allyl-l-(tert-butyloxycarbonyl)- piperidine-4-carboxylate in 30 cm3- of tetrahydrofuran, stirred at a temperature in the region of -lO°C under an inert atmosphere, while keeping the temperature below O°C. After the addition, the temperature of the mixture is brought to about 2 0°C and the mixture is then stirred for a further 4 hours. 3.1 g of 4-bromo-3-chloro-6-methoxyquinoline are added, followed by 50 cm3 of dioxane, 6.4 g of tribasic potassium phosphate and 0.22 g of diphenylphosphinoferrocene palladium chloride. The reaction mixture is heated at a temperature in the region of 50°C for 16 hours. After cooling to a temperature in the region of 20°C, the mixture is filtered and the cake is then washed with 3 times 50 cm3 of ethyl acetate. The filtrate is washed with 100 cm3 of water and then with twice 50 cm3 of saturated aqueous sodium chloride solution. The organic phase is dried over magnesium sulfate, filtered and concentrated under reduced pressure (5 kPa), at a temperature in the region of 40°C. A brown oil is obtained, which is purified by chromatography, under a pressure of 50 kPa of nitrogen, on a column of silica gel (particle size 20-45 li; diameter 4.5 cm; height 42 cm) , eluting with a mixture of cyclohexane/-ethyl acetate (80/20 by volume). The fractions containing the expected product are collected. These fractions are combined and then concentrated under reduced pressure (5 kPa) at a temperature in the region of 40°C. 2.62 g of ethyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1- (tert-butyloxycarbonyl)piperidine-4-carboxylate are obtained in the form of a yellow oil. Infra-red spectrum: (CH2CI2) : 1720; 1682; 1622; 1504; 1423; 1367; 1229; 1174; 1027 and 834 cm3Ethyl 4-allyl-l-(tert-butyloxycarbonyl)-piperidine-4-carboxylate was prepared in Example 1. Example 6 Sodium salt of 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl] -l-heptylpiperidine*4-carboxylic acid. A mixture of 0.48 g of benzyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-l-heptylpiperidine-4-carboxylate in 7 cm3 of aqueous 5 M hydrochloric acid is maintaied at a temperature in the region of 100°C, with stirring and under an inert atmosphere, for 6 hours. After cooling to about 20°C, the reaction mixture is stirred for 24 hours and then evaporated under reduced pressure (5 kPa) at a temperature in the region of 40°C. The residue obtained is purified by chromatography under a nitrogen pressure of 100 kPa, on a column of silica gel (particle size 40-60 -; diameter 2.5 cm, height 35 cm), eluting with a mixture of dichloromethane/methanol/-aqueous ammonia (84/15/1 by volume) and collecting 40-cm3-fractions, Fractions 19 to 24 are combined and then concentrated as above. The solid obtained is stirred in 10 cm3 of diisopropyl ether, filtered and washed with 3 times 5 cm of diisopropyl ether. 0.35 g of the sodium salt of 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-heptylpiperidine-4-carboxylic acid is obtained in the form of a solid melting at 223°C. 1H NMR spectrum (300 MHz, (CD3)2SO-d6, C in ppm): 0.87 (t, J = 7 Hz: 3H); from 1.10 to 1.45 (mt: 12H); from 1.45 to 1.70 (mt: 4H); from 1.85 to 2.05 (mt: 2H); 1,97 (broad d, J = 10.5 Hz: 2H); 2.17 (broad t, J = 7.5 Hz: 2H); from 2.45 to 2.60 (mt: 2H); 3.15 (mt: 2H); 3.97 (s: 3H); 7.40 (mt: 1H); 7.44 (dd, J = 9 and 3 Hz: 1H); 7.95 (d, J = 9 Hz: 1H); 8.66 (s: 1H) . Benzyl 4- [3-{3-chloro-6-methoxy(iuinolin-4-yl)propyl] -1-heptylpiperldine-4-carboxylate. 1.36 g of benzyl 4-[3-(3-chloro-6-methoxy-quinolin-4-yl)propyl]piperidine-4-carboxylate and 0.5 g of potassium carbonate are added, at a temperature in the region of 20°C, with stirring and under an inert atmosphere, to a solution of 0.61 cm3 of 1-iodoheptane in 45 cm3- of acetonitrile. After heating for 18 hours at a temperature in the region of 80°C, a further 1.17 cm3 of 1-iodoheptane are added. After heating for 4 0 hours at a temperature in the region of 80°C, the reaction mixture is cooled to about 20°C, filtered and concentrated under reduced pressure (1 kPa) at a temperature in the region of 50°C. The residue obtained is purified by chromatography under a nitrogen pressure of 100 kPa, on a column of silica gel (particle size 40-60 ji; diameter 3.5 cm; height 35 cm), eluting with a mixture of dichloromethane/methanol (95/05 by volume) and collecting 35-cm3 fractions. Fractions 18 to 26 are combined and then concentrated as above. 0.36 g of benzyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-heptylpiperidine-4-carboxylate is obtained. Infra-red spectrxim (CH2CI2) : 2957; 2931; 1722; 1622; 1504; 1229; 1159; 1118; [lacuna] Benzyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate was prepared as described in Example 1. Example 7 4-[3-(3-Chloro-6-methoxyguinolin-4-yl)propyl]-1-[2-(cyclopent:ylthio)et:hyl]piperidine-4-carboxylic acid dlhydrochloride• A mixture of 0.55 g of ethyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(cyclopentylthio)-ethyl]piperidine-4-carboxylate in 8 cm3 of aqueous 6 N hydrochloric acid is heated at a temperature in the region of lOO°C, with stirring and under an inert atmosphere, for 5 hours. After stirring for 18 hours at a temperature in the region of 20°C, the solution obtained is concentrated under reduced pressure (5 >cPa) at a temperature in the region of 40°C. The evaporation residue obtained is taken up in 10 cm3 ot a mixture ot dichloromethane/methanol (90/10 by volume) and then concentrated under the same conditions as above, 0.59 g of 4-[3-(3-chloro-6-methoxyquinolin-4"yl)propyl]-1-[2-(cyclopentylthio)ethyl]piperidine-4-carboxylic acid dihydrochloride is obtained in the form of a foam melting at 129°C with softening. 1H NMR spectrum: (300 MHz, (CD3)2SO-d6, C in ppm) : from 1.30 to 2.10 (mt: 14H); 2.15 (broad d, J = 13.5 Hz: 2H); from 2.65 to 3,00 (mt: 4H); from 3.05 to 3.40 (mt: 5H); 3.46 (broad d, J= 12 Hz: 2H); 3.97 (s: 3H); 7.42 (d, J = 2.5 Hz: 1H); 7.48 (dd, J = 9 and 2.5 Hz: 1H); 7.99 (d, J = 9 Hz: 1H); 8.72 (s: 1H); from 10.55 to 10.90 (multiplet: 1H). Ethyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(cyclopentylthio)ethyl]piperidine-4-carboxylate. 1.2 g of ethyl 4-[3-(3-chloro-6-methoxy-quinolin-4-yl)propyl]piperidine-4-carboxylate, 0.51 g of potassium carbonate and 0.61 g of potassium iodide are added, at a temperature in the region of 20'°C, with stirring and under an inert atmosphere, to a solution of 0.607 g of (2-chloroethylthio)cyclopentane in 50 cm3 of acetonitrile. After heating for 20 hours at a temperature in the region of 80°C, the reaction mixture is cooled to about 20°C, filtered and concentrated under reduced pressure (1 kPa) at a temperature in the region of 50°C. = 3 Hz: 1H); 7.44 (dd, J = 9 and 3 Hz: 1H); 7.60 (dd, J = 5.5 and 1 Hz: 1H); 7.95 (d, J = 9 Hz: 1H); 8.66 (s: 1H). Example 9 {4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(cyclopentylthlo)ethyl]piperldine-4-yl}inethanol. Working in a manner analogous to that of the preceding examples, {4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(cyclopentylthio)ethyl]piperidine-4-yl}methanol is prepared. 1H NMR spectrum (300 MHz, (CD3)2SO-d6, C in ppm): from 1.15 to 1.7 5 (mt: 14H); 1.95 (mt: 2H); from 2.20 to 2.40 (mt: 4H); 2.44 (mt: 2H); 2.57 (mt: 2H); from 3.05 to 3.25 (mt: 5H); 3.97 (s: 3H); 4.38 (t, J = 5.5 Hz: 1H); 7.38 (d, J = 3 Hz: 1H); 7.45 (dd, J = 9 and 3 Hz: 1H); 7.96 (d, J = 9 Hz: 1H); 8.68 (s: 1H) . ExaiiQ)le 10 4-[3-{3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[(3-pheiiylpropyl) piper idine- 4 -yl ] methanol. Working in a manner analogous to that of the preceding examples, 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-l-[(3-phenylpropyl)piperidine-4-yl]methanol is prepared- 1H NMR spectriim (3 00 MHz, (CD3)2SO-d6, C in ppm): 1.59 (mt: 2H); from 1.65 to 1.95 (mt: 4H); 2.20 (broad d, J = 13.5 Hz: 2H); 2.86 (mt: 2H); from 3.10 to 3.65 (mt: 8H); 3.99 (s: 3H); 7.19 (broad dd, J = 7.5 and 4.5 Hz: 1H); from 7.35 to 7.50 (mt: 2H); 7.50 (dd, J = 9 and 3 Hz: 1H); 7.71 (resolved t, J = 7.5 and 1.5 Hz: 1H); 8.01 (d, J = 9 Hz: 1H); 8.48 (broad d, J = 4.5 Hz: 1H); 8.74 (s: 1H); 10.70 (multiplet: 1H). Example 11 4- [3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl] -1- [2-(thien-2-yl)thioethyl]piperidine-4-carboxylic acid A mixture of 0.4 g of ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(thien-2-yl)thioethyl]-piperidine-4-carboxylate in 5 cm3 of aqueous 5N hydrochloric acid and 3 cm3 of dioxane is maintained at a temperature in the region of 100°C with stirring and under an inert atmosphere for 20 hours. After cooling to about 20°C, the reaction mixture is concentrated to dryness under reduced pressure (2 IcPa) at a temperature in the region of 40°C. The mixture is filtered and then chromatographed, under atmospheric pressure, on a column of silica gel (particle size 40-63 |X; diameter 1.5 cm; mass 55 g), eluting with a mixture of chloroform/-methanol/aqueous ammonia (12/3/0.5 by volume) and collecting 15-cm3 fractions. Fractions 5 to 12 are combined and then concentrated to dryness under the above conditions. 0.26 g of 4-[3-(3-fluoro-6-methoxyquinolin'4-yDpropyl] -1- [2- (thien-2-yl) thioethyl]piperidine-4-carboxylic acid is obtained in the form of a white crystalline solid melting at 180°C. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) : 1.31 (very broad t), J = 13 Hz: 2H); from 1.50 to 1.70 (mt: 4H); from 1.85 to 2.05 (mt: 4H); 2.45 (broad t, J = 7 Hz: 2H); 2.60 (broad d, J - 11 Hz: 2H); 2.91 (broad t, J = 7 Hz: 2H); 3.04 (very broad t, J = 6 Hz: 2H); 3.96 (s: 3H); 7.04 (dd, J = 5 and 3.5 Hz: 1H); 7.17 (dd, J = 3.5 and 1 Hz: 1H); 7.35 (d, J = 2.5 Hz: 1H); 7.40 (dd, J = 9 and 2.5 Hz: 1H); 7.60 (dd, J = 5 and 1 Hz: 1H); 7.97 (d, J = 9 Hz: 1H); 8.70 (broad s: 1H), Ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(thien-2-yl)thioethyl]piperidine-4-carboxylate A mixture of 0.8 g of ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate, 0.6 g of 2-(2-bromoethylthio)thiophene and 1.5 g of potassium carbonate in 10 cm3 of acetonitrile is heated for 18 hours at a temperature in the region of 80°C, with stirring and under an inert atmosphere. After cooling to a temperature in the region of 20°C, the reaction mixture is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C, The residue obtained is taken up in dichloromethane and water. The organic phase is washed with water and a saturated sodium chloride solution, dried over magnesiiim sulfate, filtered and concentrated to dryness under the above conditions. The residue is purified by chromatography under atmospheric pressure, on a column of silica gel (particle size 70-200 -; diameter 3 cm; mass 50 g), eluting with a mixture of ethyl acetate/petroleum ether (40-65°C) (75/25 by volume) and collecting 30-cm3 fractions. Fractions 3 to 5 are combined and then concentrated to dryness under the above conditions. 0.7 g of ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(thien-2-yl)thioethyl]piperidine-4-carboxylate is obtained in the form of a thick colorless oil. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) : 0.99 (t, J = 7 Hz: 3H); 1.34 (very broad t, J = 12 Hz: 2H); from 1.45 to 1.65 (mt: 4H); from 1.85 to 2.00 (mt: 4H); 2.44 (broad t, J = 7 Hz: 2H); 2.59 (broad d, J = 11.5 Hz: 2H); 2.89 (broad t, J = 7 Hz: 2H); 3.03 (very broad t, J = 6.5 Hz: 2H); 3.94 (s: 3H); 3.96 (q, J = 7 Hz: 2H); 7.02 (dd, J = 5 and 3.5 Hz: 1H); 7.16 (dd, J = 3.5 and 1 Hz: 1H); 7.32 (d, J = 2.5 Hz: 1H); 7.39 (dd, J =9 and 2.5 Hz: 1H); 7.58 (dd, J = 5 and 1 Hz: 1H); 7.96 (d, J = 9 Hz: 1H); 8.69 (broad s: 1H). Ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl] piperidine-4-carboxylate 2 cm3 of trifluoroacetic acid are added, with stirring and under an inert atmosphere, at a temperature in the region of 5°C, to a solution of 0.5 g of ethyl 4-[3-{3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-(tert-butyloxycarbonyl)piperidine-4-carboxylate in 10 cm3- of dichloromethane. After 45 minutes, the reaction mixture is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue is taken up in diethyl ether and washed with a saturated potassium bicarbonate solution and then with a saturated potassium carbonate solution. The organic phase is washed with twice 5 cm3 of water and then with a saturated sodium chloride solution, dried over magnesium sulfate, filtered and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. 0.26 g of ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)-propyl]piperidine-4-carboxylate is obtained in the form of a thick oil. 1H NMR Spectrum (300 MHz, {CD3)2SO-d6,δ in ppm) : 1.02 (t, J = 7 Hz: 3H); 1.28 (mt: 2H); from 1.45 to 1.70 (mt: 4H); 1.90 (broad d, J = 13.5 Hz: 2H); 2.46 (broad t, J = 12 Hz: 2H); 2.79 (d mt, J = 12 Hz: 2H); 3.06 (broad t, J = 6 Hz: 2H); 3.95 (s: 3H); 3.98 (q, J = 7 Hz: 2H); 7.35 (d, J = 2.5 Hz: 1H); 7.40 (dd, J = 9 and 2.5 Hz: 1H); 7.97 (d, J = 9 Hz: 1H); 8.70 (d, J = 1 Hz: 1H). Ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyll-1-(tert-butyloxycarbonyl)piperidine-4-carboxylate 1.4 g of ethyl 4-allyl-l-(tert-butyloxycarbonyl )piperidine-4-carboxylate are cooled to a r; .' temperature in the region of -30°C and 11 cm of a 0 . solution of 9-borabicyclo[3.3.l]nonane in tetrahydrofu; r are added, with stirring and under an inert atmospher( . After the addition, the temperature of the mixture is returned to about 20°C. The solution obtained is stirr <. for a further hours followed by addition of g : palladium diphenylphosphinoferrocene chloride and triba:. potassium phosphate. after stirring at ci temperature in the region reaction mixtui cooled to about then concentrated dryi :: under reduced pressure kpa tlu residue obtained is taken up acetate water phases are separated settling organic phase dried over magnesium sulfate filtered dryness i purified chromatography onfi atmospheric on column silica gel ic size diameter cm mass elutiiki v h mixture dichloromethane volume collecting fractions. fractions m combined uri-i-: above conditions ethyl lucres t. methoxyquinolin-4-yl> butyloxycarbonyl)piperidine-4-carboxylate are obta i r! 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) 1.02 (t, J = 7 Hz: 3H); 1.30 (mt:2H); 1.39 (s: 9H); from 1.45 to 1.70 (mt: 4H); 1.92 (broad d, J = 13.5 Hz: 2H); 2.81 (mt: 2H); 3.05 (broad t, J = 6.5 Hz: 2H); 3.69 (broad d, J = 13.5 Hz: 2H); 3.95 (s: 3H); 4.00 (q, J = 7 Hz: 2H); 7.34 (d, J = 2.5 Hz: 1H); 7.40 (dd, J = 9 and 2.5 Hz: 1H); 7.97 (d, J = 9 Hz: 1H); 8.70 (d, J = 1 Hz: 1H). 4-Iodo-3-£luoro-6-methoxyquinoline 1.8 cm3 of diisopropylamine in 80 cm3 of tetrahydrofuran are cooled to a temperature in the region of -75°C and 7.7 cm3 of a 1.6 M solution of butyl lithium in hexane are added, with stirring and under an inert atmosphere. After stirring for 20 minutes at a temperature in the region of -75°C, a solution of 2.2 g of 3-fluoro-6-methoxyquinoline in 20 cm3 of tetrahydrofuran is added. The solution obtained is stirred for a further 4 hours, followed by addition of a solution of 3.3 g of double-sublimated iodine in 10 cm3 of tetrahydrofuran. After stirring for 2 hours at a temperature in the region of 2 0°C, the reaction mixture is hydrolyzed with 200 cm3- of a 90/10 tetrahydrofuran/-water mixture and then 100 cm3 of a saturated sodium chloride solution and 150 cm3 of ethyl acetate. The mixture is washed with 3 times 80 cm3- of a saturated sodium chloride solution, dried over magnesium sulfate. filtered and concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue obtained is purified by chromatography, under atmospheric pressure, on a column of silica gel (particle size 70-200 -; diameter 5 cm; height 35 cm), eluting with a mixture of 90/10 petroleum ether/ethyl acetate. Fractions 66 to 95 are combined and then concentrated to dryness under reduced pressure (5 kPa) at a temperature in the region of 40°C. 0.9 g of 4-iodo-3-fluoro-6-methoxyquinoline is obtained in the form of a cream-colored solid. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) : 4.00 (s: 3H); 7.31 (d, J = 2.5 Hz: 1H); 7,47 (dd, J = 9 and 2,5 Hz: 1H); 8.01 (d, J = 9 Hz: 1H); 8.64 (s: 1H). 3-Fluoro-6-methoxy A mixture of 1.35 g of 4-chloro-3-fluoro-6-methoxyquinoline, 1.1 cm3 of triethylamine and 100 mg of palladium-on-charcoal in 23 cm3 of methanol is stirred at a temperature in the region of 20°C under a pressure of 2 bar of hydrogen for 18 hours. The reaction mixture is filtered and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C, The residue obtained is purified by chromatography under atmospheric pressure, on a column of silica gel (particle size 70-200 -i; diameter 3 cm; mass 40 g) , eluting with dichloromethane/ethyl acetate (95/5 by volume). The fractions containing the product are combined and then concentrated to dryness according to the above conditions. 1 g of 3-fluoro-6-methoxyquinoline is obtained. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) : 3.92 (s: 3H); 7.40 (mt: 2H); 8.07 (d, J = 9 Hz: 1H); 8.04 (dd, J = 10 and 3 Hz: 1H); 8.77 (d, J = 3 Hz: 1H). 4-Chloro-3-fluoro-6-xnethoKyquinoline 1.3 cm3- of diisopropylamine in 50 cm3- of tetrahydrofuran are cooled to a temperature in the region of -75°C and 5.8 cm3 of a 1.6 M solution of butyl lithium in hexane are added, with stirring and under an inert atmosphere. After stirring for 2 0 minutes at a temperature in the region of -75°C, a solution of 1.2 g of 4-chloro-6-methoxyquinoline in 20 cm3- of tetrahydrofuran is added. The solution obtained is stirred for a further 4 hours, followed by addition of a solution of 2.9 g of N-f luorobenzene sulfonimide in 10 cm3- of tetrahydrofuran. After stirring for 2 hours at a temperature in the region of 20°C, the reaction mixture is hydrolyzed with 200 cm3 of a 90/10 tetrahydrofuran/-water mixture and then 100 cm3 of a saturated sodium chloride solution and 150 cm3 of ethyl acetate. The mixture is washed with 3 times 80 cm3- of a saturated sodium chloride solution, dried over magnesium sulfate, filtered and concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue obtained is purified by chromatography, under atmospheric pressure, on a coliimn of silica gel (particle size 70-200 -l; diameter 4 cm; mass 100 g) , eluting with dichloromethane. The fractions containing the product are combined and then concentrated to dryness under reduced pressure (5 kPa) at a temperature in the region of 40°C. 0.4 g of 4-chloro-3-fluoro-6-methoxyquinoline is obtained. 1H NMR Spectriim (300 MHz, (CD3)2SO-d6,δ in ppm) : 4.01 (s: 3H); 7.43 (d, J = 2.5 Hz: 1H); 7.52 (dd, J = 9 and 2.5 Hz: 1H); 8.07 (d, J = 9 Hz: 1H); 8.91 (d, J = 1 Hz: 1H). 4-Chloro-6-zoethoxyqulnoline A mixture of 12 g of 4-hydroxy-6-methoxy-quinoline in 50 cm3- of [lacuna] oxychloride [lacuna] inert atmosphere, for 2 hours. After cooling to about 20°C, the reaction mixture is concentrated to dryness under reduced pressure (2 IcPa) at a temperature in the region of 40°C and then hydrolyzed with ice and brought to pH = 10 using a 5 N sodium hydroxide solution. The mixture is extracted with ethyl acetate, dried over magnesium sulfate, filtered and concentrated to dryness under reduced pressure (2 IcPa) at a temperature in the region of 40°C. The residue obtained is chromatographed, under atmospheric pressure, on a column of silica gel (particle size 70-200 \x) , eluting with a mixture of dichloromethane/methanol (85/15 by volume). The fractions containing the product are combined and then concentrated to dryness according to the above conditions. 12 g of 4-chloro-6-methoxyquinoline are obtained in the form of a white solid melting at 82°C. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) : 3.958 (s: 3H); 7.45 (d, J = 2.5 Hz: 1H); 7.53 (dd, J = 9 and 2.5 Hz: 1H); 7.76 (d, J = 4.5 Hz: 1H); 8.04 (d, J = 9 Hz: 1H); 8.70 (d, J = 4.5 Hz: 1H). The ethyl 4-allyl-l-(tert-butyloxycarbonyl)-piperidine-4-carboxylate was prepared in Example 1. The 4-hydroxy-6-methoxyquinoline was prepared as described in Example 1. Exattqple 12 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluoro-6-phenoxy)ethyl]piperidine-4-carboxylic acid A mixture of 0.4 g of ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluoro-6-phenoxy)ethyl]piperidine-4-carboxylate in 6 cm3 of aqueous 5N hydrochloric acid and 10 cm3- of dioxane is maintained at a temperature in the region of lOO°C, with stirring and under an inert atmosphere, for 20 hours. After cooling to about 20°C, the reaction mixture is concentrated to dryness under reduced pressure (2 IcPa) at a temperature in the region of 40°C. The residue obtained is chromatographed, at atmospheric pressure, on a column of silica gel (particle size 70-200 -i; diameter 1.5 cm; mass 50 g), eluting with a mixture of chloroform/methanol/aqueous ammonia (12/3/0.5 by volume) and collecting 15-cm3 fractions. Fractions 10 to 15 are combined and then concentrated to dryness according to the above conditions. 0.2 g of 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluoro-6-phenoxy)ethyl]piperidine-4-carboxylic acid is obtained in the form of a white solid melting at 175°C. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) : 1.33 (very broad t, J = 13 Hz: 2H) ; from 1.50 to 1.70 (mt: 4H); 1.95 (broad d, J = 13 Hz: 2H); 2.05 (broad t, J = 11.5 Hz: 2H); 2.60 (t, J = 6 Hz: 2H); 2.69 (broad d, J = 11.5 Hz: 2H); 3.04 (mt: 2H); 3.96 (s: 3H); 4.06 (t, J = 6 Hz: 2H); from 6.65 to 6.85 (mt: 3H); 7.34 (d, J = 2.5 Hz: 1H); 7.39 (dd, J = 9 and 2.5 Hz: 1H); 7.96 (d, J = 9 Hz: 1H); 8.69 (broad s: 1H). Ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluoro-6-phenoxy)ethyl]piperidine-4-carboxylate A mixture of 0.4 g of ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl] piperidine-4-carboxylate, 0-3 g of 1-(2-bromoethoxy)-3,5-difluorobenzene, 0.18 g of potassium iodide and 0.74 g of potassium carbonate in 10 cm3- of acetonitrile is heated for 18 hours at a temperature in the region of 75°C, with stirring and under an inert atmosphere. After cooling to a temperature in the region of 20°C, the reaction mixture is concentrated to dryness under reduced pressure (5 kPa) at a temperature in the region of 40°C. The residue obtained is taken up in ethyl acetate and water. The organic phase is washed with water and a saturated sodium chloride solution, dried over magnesium sulfate, filtered and concentrated to dryness under the above conditions. The residue is purified by chromatography, under atmospheric pressure, on a column of silica gel (particle size 70-200 )ii; diameter 1.5 cm; mass 35 g) , eluting with dichloromethane. Fractions 7 to 11 are combined and then concentrated to dryness according to the above conditions, 0.4 g of ethyl 4-[3-(3-fluoro-6-methoxy-quinolin-4-yl)propyl]-1-[2-(3,5-difluoro-6-phenoxy)-ethyl]piperidine-4-carboxylate is obtained in the form of a thick colorless oil. 1H NMR Spectrum (300 ]-z, (CD3)2SO-d6,δ in ppm) : 1.00 (t, J = 7 Hz: 3H); 1.38 (very broad t, J = 12 Hz: 2H); from 1.45 to 1.70 (mt: 4H); from 1.90 to 2.10 (mt: 4H); 2,60 (t, J = 6 Hz: 2H); 2.69 (very broad d, J = 12 Hz: 2H); 3.05 (very broad t, J = 6.5 Hz: 2H); 3.95 (s: 3H); 3.98 (q, J = 7 Hz: 2H); 4.06 (t, J = 6 Hz: 2H); from 6,65 to 6,85 (mt: 3H); 7.34 (d, J = 2.5 Hz: 1H); 7.40 (dd, J = 9 and 2,5 Hz: 1H); 7,97 (d, J = 9 Hz: 1H); 8.70 (broad s: 1H). The ethyl 4-allyl-l-(tert-butyloxycarbonyl)-piperidine-4-carboxylate is prepared in Example 1. The 1-(2-bromoethoxy)-3,5-difluorobenzene may be obtained by applying the method described in Example 16. Exeutg)le 13 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-l-[2- (2,3,5-trifluoro-6-phenoxy)ethyl]piperidine-4-carboxylic acid dihydrochloride A mixture of 1 g of benzyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluoro-6-phenoxy)ethyl]piperidine-4-carboxylate in 50 cm3 of aqueous 5N hydrochloric acid is maintained at a temperature in the region of lOO°C with stirring for 20 hours. After cooling to about 20°C, the reaction mixture is concentrated to dryness under reduced pressure (2 ]cPa) at a temperature in the region of 40°C. The residue obtained is taJcen up in 50 cm3- of acetone, filtered, washed with 3 times 15 cm3 of [lacuna] and then dried in a desiccator under reduced pressure (0.1 ]cPa) at a temperature in the region of 40°C. 0.88 g of 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-tri-fluoro-6-phenoxy)ethyl]piperidine-4-carboxylic acid dihydrochloride is obtained in the form of a white solid melting at IVO°C. •1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) from 1.45 to 2.30 (mt:8H); from 2.85 to 3.70 (mt: 8H); 3.97 (s: 3H); 4.50 (mt: 2H); 7.15 (mt: 2H); 7.40 (d, J = 3 Hz: IH ); 7.46 (dd, J = 9 and 3 Hz: 1H); 7.97 (d, J = 9 Hz: 1H); 8.69 (s: 1H); 10.07 (unresolved peak: 1H); from 12-50 to 13.10 (broad unresolved peak: 1H). Benzyl 4-[3-{3"Chloro-6-methoxyquinoliii-4-yl)propyl]-1-[2-(2,3,5-trifluoro-6-phenoxy)ethyl]piperidine-4-carboxylate A mixture of 1.4 g of benzyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate hydrochloride, 0.9 g of 1-(2-bromoethoxy)-2,3,5-tri-fluorobenzene, 0.6 g of potassium iodide and 2 g of potassium carbonate in 100 cm3 of acetonitrile is heated for 18 hours at a temperature in the region of 75°C with stirring and under an inert atmosphere. After cooling to a temperature in the region of 2 0°C, the reaction mixture is filtered and washed with 3 times 30 cm3 of acetonitrile. The filtrate is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue obtained is purified by chromatography under atmospheric pressure, on a column of silica gel (particle size 20-45 \i; diameter 3 cm; height: 27 cm), eluting with ethyl acetate and collecting 50-cm3 fractions. Fractions 9 to 23 are combined and then concentrated to dryness according to the above conditions, 1.27 g of benzyl 4-[3-(3-chloro-6-methoxy-quinolin-4-yl)propyl]-1-[2-(2,3,5-trifluoro-6-phenoxy)-ethyl]piperidine-4-carboxylate are obtained in the form of a thick yellow oil. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) from 1.30 to 1.60 (mt: 4H); 1.72 (mt: 2H); from 1.95 to 2.15 (mt: 4H); 2.64 (t, J = 5.5 Hz: 2H); 2.71 (d-unresolved peak, J = 12 Hz: 2H); 3,13 (broad t, J = 7.5 Hz: 2H); 3.93 (s: 3H); 4.16 (t, J = 5.5 Hz: 2H); 5.04 (s 2H); from 6.95 to 7.15 (mt: 2H); from 7.20 to 7.30 (mt: 5H); 7.34 (d, J = 3 Hz: 1H); 7.45 (dd, J = 9 and 3 Hz: 1H); 7.97 (d, J = 9 Hz: 1H); 8.67 (s: 1H). Benzyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-piperidine-4-carboxylate hydrochloride A mixture of 17.4 g of benzyl 1-tert-butyloxycarbonyl-4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate in 75 cm3 of 5N hydrochloric acid dissolved in dioxane and 200 cm3 of dioxane is stirred at a temperature in the region of 2 0°C for 20 hours. 200 cm3 of diethyl ether are added to the reaction mixture. The precipitate formed is filtered off to give 14.26 g of benzyl 4-[3-(3-fluoro-6-methoxy-quinolin-4-yl)propyl]piperidine-4-carboxylate hydrochloride. 1H NMR Spectriim (300 MHz, (CD3)2SO-d6,δ in ppm): 1.49 (mt: 2H); from 1.65 to 1.85 (mt: 4H); 2.11 (d-unresolved peak , J = 14 Hz: 2H); 2.78 (mt: 2H); from 3.10 to 3.25 (mt: 2H); 3.20 (broad t, J = 7.5 Hz: 2H); 3.96 (s: 3H); 5.09 (s: 2H); 7.28 (mt: 5H); 7.43 (d, J = 3 Hz: 1H); 7.53 (dd, J = 9 and 3Hz: 1H); 8.06 (d, J = 9 Hz: 1H); 8.80 (s: 1H); from 9-05 to 9.30 (unresolved peak: 2H). 1- (2-Broxnoethoxy) -2,3,5-tri£luorobenzene A mixture of 11.4 g of 2,3,5-trifluorophenol, 40.5 cm3 of 1,2-dibromoethane and 15.3 g of potassium carbonate in 200 cm3 of acetonitrile is heated for 18 hours at a temperature in the region of 75°C, with stirring and under an inert atmosphere. After cooling to a temperature in the region of 20°C, the reaction mixture is filtered and washed with 4 times 50 cm3- of acetonitrile. The filtrate is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue obtained is taken up in 150 cm3 of petrole\im ether (40-65°C) , filtered and washed with 3 times 30 cm3 of petroleum ether (40-65°C) . The filtrate is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue obtained is purified by chromatography under atmospheric pressure, on a column of silica gel (particle size 20-45 \i; diameter 5 cm; height: 33 cm) , eluting with petroleum ether (40-65°C) and collecting lOO-cm3-fractions. Fractions 28 to 63 are combined and then concentrated to dryness according to the above conditions. 16.15 g of 1-(2'bromoethoxy)-2,3,5-trifluorobenzene are obtained in the form of a thick colorless oil - 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) 3.83 (broad t, J = 5.5 Hz: 2H) ; 4,45 (broad t, J = 5,5 Hz: 2H); from 7.00 to 7.15 (mt: 2H). The benzyl 4-allyl-l-(tert-butyloxycarbonyl)-piperidine-4-carboxylate was prepared in Example 1. Example 14 4- [3-{3-Chloro-6-methoxyquinolin-4-yl)propyl]-l- [2- (2,5-difluoro-6-phenylthio)ethyl]piperidine-4-carboxylic acid A mixture of 1.3 g of benzyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,5-difluoro-6-[lacuna]piperidine-4-carboxylate in 15 cm3 of aqueous 5N hydrochloric acid and 15 cm3- of dioxane is maintained at a temperature in the region of 100°C with stirring and under an inert atmosphere for 20 hours. After cooling to about 20°C, the reaction mixture is evaporated under reduced pressure (2 JcPa) at a temperature in the region of 40°C. The residue obtained is talcen up 4 times in toluene, evaporating between each washing. The oil obtained is taken up in a chloroform/methanol/aqueous ammonia mixture (12/3/0.5 by volume), the phases are separated by settling and the organic phase is washed with water and then left to crystallize for 20 hours. The solid obtained is filtered off and then dried in a desiccator under reduced pressure (0.1 kPa) at a temperature in the region of 40°C. 0-6 g of 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,5-difluoro-6-phenylthio)ethyl]piperidine-4-carboxylic acid is obtained in the form of a white crystalline solid melting at 205°C, 1H NMR Spectrum (400 MHz, (CD3)2SO-d6,δ in ppm) : 1,39 (unresolved peak: 2H) ; 1.55 (mt: 2H) ; 1.70 (mt: 2H) ; from 1.90 to 2.20 (mt: 4H); from 2.40 to 2.85 (broad unresolved peak: 4H); from 3.05 to 3.25 (mt: 2H); 3.17 (broad t, J = 7.5 Hz: 2H); 3.96 (s: 3H); 7.07 (mt: 1H); 7.26 (mt: 1H); 7.33 (mt: 1H); 7.38 (d, J = 2.5 Hz: 1H); 7.46 (dd, J = 9 and 2.5 Hz: 1H); 7.97 (d, J = 9 Hz: 1H); 8.68 (s: 1H); from 12.00 to 12.50 (unresolved peak: 1H). Benzyl 4- [3- (3-chloro-6-methOKy A mixture of 1.4 g of benzyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate, 0.9 g of 1-(2-bromoethylthio)-2,5-difluorobenzene, 0.6 g of potassium iodide and 2 g of potassium carbonate in 100 cm3 of acetonitrile is heated for 18 hours at a temperature in the region of 75°C, with stirring and under an inert atmosphere. After cooling to a temperature in the region of 20°C, the reaction mixture is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue obtained is taken up in water and extracted with ethyl acetate. The organic phase is washed with saturated sodium chloride solution, dried over magnesium sulfate and then concentrated to dryness as above. The residue obtained is purified by chromatography, under atmospheric pressure, on a column of silica gel (particle size 70-200 -; diameter 2.5 cm; mass: 50 g), eluting with a mixture of ethyl acetate and dichloromethane (05/95 by volume) and collecting 15-cm3 fractions. Fractions 21 to 100 are combined and then concentrated to dryness according to the above conditions, 1.35 g of benzyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,5-difluoro-6-phenylthio)ethyl]piperidine-4-carboxylate are obtained in the form of a white solid melting at 95°C. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) : from 1.30 to 1.60 (mt: 4H); 1.71 (mt: 2H); from 1.85 to 2.05 (mt: 4H); from 2.40 to 2.60 (mt: 2H); 2.66 (d-unresolved peak, J = 12 Hz: 2H); from 3.05 to 3.20 (mt: 2H); 3.11 (broad t, J = 7.5 Hz: 2H); 3.92 (s: 3H); 5.03 (s: 2H); 7.04 (mt: 1H); from 7.15 to 7.35 (mt: 7H); 7.35 (d, J = 3 Hz: 1H); 7.44 (dd, J = 9 and 3 Hz: 1H); 7.95 (d, J = 9 Hz: 1H); 8.66 (s: 1H). 1- (2-Bromoethylthio) -2,5-dif luorobenzene A mixture of 5.8 g of S-(2,5)-difluorophenyl-dimethyl thiocarbamate in 80 cm3 of a 10% solution of potassium hydroxide in methanol is heated for 1 hour at a temperature in the region of lOO°C with stirring and under an inert atmosphere. After cooling to a temperature in the region of 20°C, the reaction mixture is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue obtained is taken up in water, extracted with diethyl ether and then acidified with 40 cm3 of 5N hydrochloric acid. The aqueous phase is extracted with twice 30 cm3 of diethyl ether. The organic phases are combined, washed with saturated sodium chloride solution, dried over sodium sulfate, filtered and then concentrated to dryness as above. The residue obtained is taken up in 30 cm3 of 1,2-dibromoethane and 0.5 g of aliquat 336, followed by addition of 20 cm3 of cold sodium hydroxide solution. The solution obtained is stirred for a further 18 hours at a temperature in the region of 20°C and then washed with twice 15 cm3 of water. The organic phases are combined, washed with saturated sodium chloride solution, dried over sodium sulfate, filtered and then concentrated to dryness as above. The residue obtained is purified by chromatography under atmospheric pressure, on a column of silica gel (particle size 70-200 \i; diameter 2.5 cm; mass: 75 g), eluting with petroleum ether and collecting 50-cm3 fractions. Fractions 4 to 13 are combined and then concentrated to dryness according to the above conditions. 4,4 g of 1-{2-bromoethylthio)-2,5-difluoro-benzene are obtained in the form of a colorless fluid oil. 1H NMR Spectrum (3 00 MHz, (CD3)2SO-d6,δ in ppm) 3.50 (mt: 2H); 3.66 (mt: 2H); 7.15 (mt: 1H); 7.32 (doubled triplet, J = 9 and 4.5 Hz: 1H); 7.42 (ddd, J = 9-6.5 and 3 Hz: 1H). Dimethyl S-(2,5)-difluorophenylthiocarbamate 2 g of dimethyl 0-(2,5)-difluorophenylthiocarbamate are heated at a temperature in the region of 235°C for 40 minutes. The residue obtained is purified by chromatography under atmospheric pressure, on a column of silica gel (particle size 70-200 µi; diameter 3 cm; mass: 25 g), eluting with a mixture of petroleum ether and dichloromethane (50/50 by volume) and collecting 15-cm3-fractions. Fractions 6 to 11 are combined and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C- 1.25 g of dimethyl S-(2,5)-difluorophenylthiocarbamate are obtained in the form of a white solid melting at 96°C. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm): 2.96 (unresolved peak: 3H); 3.08 (unresolved peak: 3H); from 7.35 to 7.50 (mt: 3H). Dimethyl O-(2,5)-difluorophenylthiocarbamate 14.1 g of dimethylthiocarbamate chloride and 13 g of 1,4-diaza[2.2.2]tricyclooctane are added with stirring to a solution of 7.5 g of 2,5-difluorophenol in 12 0 cm3- of dimethylformamide. After stirring for 1 hour at a temperature in the region of 20°C, the reaction mixture is taken up in 1 dm- of water and 100 cm3 of dry concentrated hydrochloric acid, and extracted with 400 cm3 of diethyl ether. The organic phase is dried over sodium sulfate, filtered and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue obtained is purified by chromatography under atmospheric pressure, on a colunm of silica gel (particle size 70-200 ]i; diameter 10 cm; mass: 4 00 g), eluting with a mixture of petroleum ether and dichloromethane (50/50 by volume). The fractions containing the expected product are combined and then concentrated to dryness under reduced pressure (5 kPa) at a temperature in the region of 40°C. 12.4 g of dimethyl O-(2,5)-difluorophenylthiocarbamate are obtained in the form of a solid melting at 62°C. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) : 3.35 (s: 3H); 3.40 (s: 3H); from 7.15 to 7.30 (mt: 2H); 7.42 (doubled triplet, J = 9.5 and 5.5 Hz: 1H). The benzyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate hydrochloride was prepared in Example 13. Example 15 4- [3-(3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- [2- (2,6-difluorophenoxy)ethyl]piperldine-4-carboxyllc acid dihydrochloride A mixture of 1 g of benzyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,6-difluorophenoxy)-ethyl]piperidine-4-carboxylate in 50 cm3 of aqueous 5N hydrochloric acid is maintained at a temperature in the region of lOO°C, with stirring and under an inert atmosphere for 20 hours. After cooling to about 2 0°C, the reaction mixture is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C-The residue obtained is taken up in 50 cm3- of acetone and then stirred for 1 hour at a temperature in the region of 20°C. The mixture is filtered, washed with 3 times 15 cm3 of acetone and then dried in a desiccator under reduced pressure (0.1 kPa) at a temperature in the region of 40°C. 0.86 g of 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,6-difluorophenoxy)ethyl]piperidine-4-carboxylic acid dihydrochloride is obtained in the form of a white solid melting at 218°C. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) : 1.59 (mt: 2H); 1.75 (mt: 2H); 1.82 (very broad t, J = 14 Hz: 2H); 2.22 (broad d, J = 14 Hz: 2H); 2.98 (mt: 2H); 3.22 (broad t, J = 7.5 Hz: 2H); from 3.45 to 3.70 (mt: 4H); 3.98 (s: 3H); 4.51 (t, J = 5 Hz: 2H); from 7.15 to 7.25 (mt: 3H); 7.42 (d, J = 3 Hz: 1H); 7.48 (dd, J = 9 and 3 Hz: 1H); 7.99 (d, J = 9 Hz: 1H); 8.72 (s: 1H); 10.66 (unresolved peak: 1H). Benzyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl3-1-[2-(2,6-difluoropheiioxy)ethyl]piperidine-4-carboxylate A mixture of 1.4 g of benzyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate, 0.82 g of 1-{2-bromoethoxy)-2,6-difluorobenzene, 0.6 g of potassiiim iodide and 2 g of potassium carbonate in 100 cm3 of acetonitrile is heated for 18 hours at a temperature in the region of 7 5°C, with stirring and under an inert atmosphere. After cooling to a temperature in the region of 20°C, the reaction mixture is filtered and washed with three times 30 cm3 of acetonitrile. The filtrate is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C-The residue obtained is purified by chromatography under atmospheric pressure, on a column of silica gel (particle size 20-45 p; diameter 3 cm; height: 27 cm), eluting with ethyl acetate and collecting 50-cm3 fractions. Fractions 7 to 17 are combined and then concentrated to dryness under the above conditions. 1.65 g of benzyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,6-difluorophenoxy)ethyl]piperidine-4-carboxylate are obtained in the form of a thick yellow oil. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) : from 1.25 to 1.55 (mt: 4H); 1.70 (mt: 2H); from 1.90 to 2.10 (mt: 4H); 2.59 (t, J = 6 Hz: 2H); 2.66 (d-unresolved peak, J = 12 Hz: 2H); 3,13 (broad t, J = 7.5 Hz: 2H); 3.93 (s: 3H); 4.14 (t, J = 6 Hz: 2H); 5.03 (s: 2H); from 7.05 to 7.20 (mt: 3H); 7.35 (mt: 5H); 7.35 (d, J = 3 Hz: 1H); 7.46 (dd, J = 9 and 3 Hz: 1H); 7.97 (d, J = 9 Hz: 1H); 8.67 (s: 1H). 1- (2-Bromoethoxy) -2, 6-di£luorobenzene A mixture of 10 g of 2,6-difluorophenol, 40.5 cm3 of 1,2-dibromoethane and 15,3 g of potassium carbonate in 300 cm3- of acetonitrile is heated for 18 hours at a temperature in the region of 75°C, with stirring and under an inert atmosphere. After cooling to a temperature in the region of 20°C, the reaction mixture is filtered and washed with 3 times 30 cm3 of acetonitrile. The filtrate is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue obtained is taken up in 200 cm3 of petroleum ether (40-65°C) , filtered and washed with 3 times 30 cm3 of petroleum ether (40-65°C) . The filtrate is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue obtained is purified by chromatography under atmospheric pressure, on a column of silica gel (particle size 20-45 µ diameter 7 cm; height: 28 cm), eluting with petroleum ether (40-65°C) and collecting 100-cm fractions. Fractions 22 to 58 are combined and then concentrated to dryness under the above conditions, 14.5 g of 1-{2-bromoethoxy)-2,6-difluorobenzene are obtained in the form of a thick colorless oil. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) 3.76 (broad t, J = 6 Hz: 2H); 4.42 (broad t, J = 6 Hz: 2H); from 7.10 to 7.25 (mt: 3H). The benzyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate hydrochloride was prepared in Example 13, Examnple 16 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,5-difluorophenoxy)ethyl]piperidine-4-carboxylic acid dlhydrochlorlde A mixture of 1 g of benzyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,5- difluorophenoxy)ethyl]piperidine-4-carboxylate in 50 cm3 of 5N hydrochloric acid is maintained at a temperature in the region of lOO°C, with stirring and under an inert atmosphere for 20 hours. After cooling to about 20°C, the reaction mixture is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue obtained is taken up in 50 cm3- of acetone and then stirred for 1 hour at a temperature in the region of 20°C. The mixture is filtered, washed with 3 times 15 cm3 of acetone and then dried in a desiccator under reduced pressure (0.1 kPa) at a temperature in the region of 40°C. 0.8 g of 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,5-difluorophenoxy)ethyl]piperidine-4-carboxylic acid dihydrochloride is obtained in the form of a white solid melting at ISO°C. 1H NMR Spectrum (400 MHz, (CD3)2SO-d6,δ in ppm) 1.58 (mt: 2H); 1.72 (mt: 2H); 1.84 (very broad t, J = 14 Hz: 2H); 2.19 (broad d, J = 14 Hz: 2H); 2.95 (mt: 2H); 3.22 (broad t, J = 7.5 Hz: 2H); 3.53 (mt: 4H); 3.98 (s: 3H); 4.52 (t, J = 5 Hz: 2H); 6.84 (mt: 1H); 7.22 (ddd, J =9-7 and 3 Hz: 1H); 7.30 (ddd, J = 10.5 - 9 and 4.5 Hz: 1H); 7.42 (d, J = 2.5 Hz: 1H); 7.49 (dd, J = 9 and 2.5 Hz: 1H); 8.00 (d, J = 9 Hz: 1H); 8.74 (s: 1H); 10.97 (unresolved pealc: 1H) . Benzyl 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1-[2-(2,5-difluorophenoxy)ethyl]piperidine-4-carboxylate A mixture of 1.4 g of benzyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate hydrochloride, 0.82 g of 1-(2-bromoethoxy)-2,5-difluoro-benzene, 0.6 g of potassium iodide and 2 g of potassium carbonate in 100 cm3- of acetonitrile is heated for 18 hours at a temperature in the region of 75°C with stirring and under an inert atmosphere. After cooling to a temperature in the region of 20°C, the reaction mixture is filtered and washed with 3 times 30 cm3 of acetonitrile. The filtrate is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue obtained is purified by chromatography under atmospheric pressure, on a column of silica gel (particle size 20-45 ]i; diameter 2.4 cm; height: 26 cm), eluting with ethyl acetate and collecting 30-cm3 fractions. Fractions 7 to 14 are combined and then concentrated to dryness under the above conditions. 1.6 g of benzyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,5-difluorophenoxy)ethyl]piperidine-4-carboxylate are obtained in the form of a thick yellow oil. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6, 8 in ppm) : from 1.35 to 1.60 (mt: 4H); 1.73 (mt: 2H); from 1.95 to 2.15 (mt: 4H); 2.63 (t, J = 5.5 Hz: 2H); 2.72 (d-unresolved peak, J = 12 Hz: 2H); 3.14 (broad t, J = 7.5 Hz: 2H); 3.92 (s: 3H); 4.12 (t, J = 5.5 Hz: 2H); 5.04 (s: 2H); 6.75 (tripled triplet, J = 9 and 3 Hz: 1H); 7.13 (ddd, J = 10.5 - 7.5 and 3 Hz: 1H); from 7.20 to 7.30 (mt: 6H); 7.34 (d, J = 3 Hz: 1H); 7.45 (dd, J = 9 and 3 Hz: 1H); 7.97 (d, J = 9 Hz: 1H); 8.67 (s: 1H). 1-(2-Bromoethoxy)-2,5-difluorobenzene A mixture of 10 g of 2,5-difluorophenol, 40.5 cm3- of 1,2-dibromoethane and 15.3 g of potassium carbonate in 200 cm3 of acetonitrile is heated for 18 hours at a temperature in the region of 75°C, with stirring and under an inert atmosphere. After cooling to a temperature in the region of 20°C, the reaction mixture is filtered and washed with 4 times 50 cm3 of acetonitrile. The filtrate is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue obtained is taken up in 150 cm3 of petroleum ether (40-65°C) , filtered and washed with 3 times 30 cm3 of petroleum ether (40-65°). The filtrate is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue obtained is purified by chromatography under atmospheric pressure, on a column of silica gel (particle size 20-45 µ diameter 7 cm; height: 49 cm), eluting with petroleum ether (40-65°C) and collecting 100-cm3 fractions. Fractions 29 to 88 are combined and then concentrated to dryness under the above conditions. 13.5 g of 1-(2-bromoethoxy)-2,5-difluorobenzene are obtained in the form of a colorless fluid oil. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) : 3.85 (broad t, J = 6 Hz: 2H); 4.44 (broad t, J = 6 Hz: 2H); 6.82 (mt: 1H); 7.18 (ddd, J = 9 - 7 and 3 Hz: 1H); 7.29 (ddd, J = 11 - 9 and 5 Hz: 1H). The benzyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate hydrochloride was prepared in Example 13. Example 17 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3-difluorophenoxy)ethyl]piperidine-4-carboxylic acid dihydrochloride A mixture of 1 g of benzyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3-difluorophenoxy)-ethyl]piperidine-4-carboxylate in 50 cm3 of aqueous 5N hydrochloric acid is maintained at a temperature in the region of 100°C, with stirring and under an inert atmosphere for 20 hours. After cooling to about 20°C, the reaction mixture is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue obtained is taken up in 50 cm3 of acetone and then stirred for 1 hour at a temperature in the region of 2 0°C. The mixture is filtered, washed with 3 times 15 cm3-of acetone and then dried in a desiccator under reduced pressure (0.1 kPa) at a temperature in the region of 40°C. 0.9 g of 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3-difluorophenoxy)ethyl]piperidine-4-carboxylic acid dihydrochloride is obtained in the form of a white solid melting at 259°C. 1H NMR Spectrum (400 MHz (CD3)2SO-d6,δ in ppm) : from 1.45 to 1.65 (mt: 2H); 1.73 (mt: 2H); 1.81 (very broad t, J = 14 Hz: 2H); 2.20 (broad d, J = 14 Hz: 2H); 2.97 (mt: 2H); 3.22 (broad t, J = 7.5 Hz: 2H); from 3.45 to 3.60 (mt: 4H); 3.98 (s: 3H); 4.54 (t, J = 5 Hz: 2H); 7.09 (mt: 2H); 7.20 (mt: 1H); 7.42 (d, J = 2.5 Hz: 1H); 7.48 (dd, J = 9 and 2.5 Hz: 1H); 7.99 (d, J = 9 Hz: 1H); 8.72 (s: 1H); 10,70 (unresolved peak: 1H); from 12.40 to 13.30 (broad unresolved peak: 1H). Benzyl 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1-[2-(2,3-difluorophenoxy)ethyl]piperidine-4-carboxylate A mixture of 1.4 g of benzyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate hydrochloride, 0.82 g of 1-(2-bromoethoxy)-2,3-difluoro-benzene, 0,6 g of potassium iodide and 2 g of potassium carbonate in 100 cm3- of acetonitrile is heated for 18 hours at a temperature in the region of 75°C, with stirring and under an inert atmosphere. After cooling to a temperature in the region of 20°C, the reaction mixture is filtered and washed with 3 times 30 cm*- of acetonitrile. The filtrate is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue obtained is purified by chromatography under atmospheric pressure, on a column of silica gel (particle size 20-45 µ diameter 2.7 cm; height: 32 cm), eluting with ethyl acetate and collecting 30-cm3- fractions. Fractions 7 to 21 are combined and then concentrated to dryness under the above conditions. 1.6 g of benzyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3-difluorophenoxy)ethyl]piperidine-4-carboxylate are obtained in the form of a thick yellow oil. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) : from 1.35 to 1.55 (mt: 4H); 1.72 (mt: 2H); from 1.95 to 2.15 (mt: 4H); 2.64 (t, J = 6 Hz: 2H); 2.72 (d-unresolved peak, J = 12 Hz: 2H); 3.13 (broad t, J = 7.5 Hz: 2H); 3.93 (s: 3H); 4.15 (t, J = 6 Hz: 2H); 5,04 (s: 2H); from 6.90 to 7.20 (mts: 3H); 7.25 (mt: 5H); 7.35 (d, J = 3 Hz: 1H); 7.45 (dd, J = 9 and 3 Hz: 1H); 7.97 (d, J = 9 Hz: 1H); 8.67 (s: 1H). 1- (2-Broznoethoxy) -2,3-di£luorobenzene A mixture of 10 g of 2,3-difluorophenol, 40.5 cm3 of 1,2-dibromoethane and 15.3 g of potassium carbonate in 200 cm3 of acetonitrile is heated for 48 hours at a temperature in the region of 75°C, with stirring and under an inert atmosphere. After cooling to a temperature in the region of 20°C, the reaction mixture is filtered and washed with 6 times 30 cm3- of acetonitrile. The filtrate is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue obtained is purified by chromatography under atmospheric pressure, on a column of silica gel (particle size 20-45 p; diameter 7 cm; height: 42 cm), eluting with a mixture of dichloromethane and ethyl acetate (90/10 by volume) and collecting 100-cm3 fractions. Fractions 4 to 10 are combined and then concentrated to dryness under the above conditions. The residue obtained is purified by chromatography under atmospheric pressure, on a column of silica gel (particle size 20-45 \x; diameter 5 cm; height: 30 cm) , eluting with petroleum ether (40-65°C) and collecting lOO-cm3-fractions. Fractions 34 to 82 are combined and then concentrated to dryness under the above conditions. 13.6 g of 1-(2-bromoethoxy)-2,3-difluorobenzene are obtained in the form of a colorless fluid oil. 1H NMR Spectrum (300 MHz, (CDsJsSO-d6,δ in ppm) : 3.85 (broad t, J = 6 Hz: 2H) ; 4.44 (broad t, J = 6 Hz: 2H); 6.82 (mt: 1H); 7.18 (ddd, J = 9 - 7 and 3 Hz: 1H); 7.29 (ddd, J = 11 - 9 and 5 Hz: 1H). The benzyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate hydrochloride was prepared in Example 13. Example 18 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-(2-thiazole-2-thioethyl)piperidlne-4-carboxylic acid A mixture of 0.3 g of ethyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-(2-thiazole-2-thi6ethyl)piperidine~4-carboxylate in 6 cm3 of aqueous 5N hydrochloric acid is maintained at a temperature in the region of lOO-°C, with stirring and under an inert atmosphere for 6 hours. After cooling and stirring for 16 hours at a temperature in the region of 20°C, the reaction mixture is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue obtained is taken up in 10 cm3- of dichloroethane containing 10% methanol, and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue obtained is purified by chromatography under atmospheric pressure, on a column of silica gel (particle size 40-60 µ; diameter 2,5 cm; height: 30 cm), eluting with a dichloroethane/methanol/aqueous ammonia mixture (89/10/1 by volume). Fractions 18 to 41 are combined and then concentrated to dryness under the above conditions. The residue obtained is taken up in 5 cm3 of isopropyl ether, filtered and dried in a desiccator under reduced pressure (0.1 kPa) at a temperature in the region of 40°C. 0.24 g of 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-(2-thiazole-2-thioethyl)piperidine-4-carboxylic acid is obtained in the form of a white solid melting at 200°C. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) : 1.34 (mt: 2H); 1.55 (mt: 2H); 1.69 (mt: 2H); from 1.85 to 2.15 (mt: 4H); 2.59 (broad t, J = 7 Hz: 2H); 2.67 (d-unresolved peak, J = 12 Hz: 2H); 3.17 (broad t, J = 6 Hz: 2H); from 3.20 to 3.50 (mt: 2H); 3.96 (s: 3H); 7.38 (broad s: 1H); 7.45 (broad dd, J = 9 and 2.5 Hz: 1H); 7.63 (d, J = 3 Hz: 1H); 7.71 (d, J = 3 Hz: 1H); 7.96 (d, J = 9 Hz: 1H); 8.68 (s: 1H); from 11.90 to 12.55 (very broad unresolved peak; 1H). Ethyl 4- [3-(3-chloro-6-methoxyquinolin-4-yl)propyl] -1- (2-thiazole-2-thioethyl)piperidine-4-carboxylate 0.28 g of 2-mercaptothiazole, 0.33 g of potassium carbonate and 0.39 g of potassium iodide are added to a solution of 0.9 g of ethyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-(2-chloroethyl)piperidine-4-carboxylate in 50 cm3- of acetonitrile at a temperature in the region of 20°C, with stirring and under an inert atmosphere. After heating for 2 0 hours at a temperature in the region of 80°C, the reaction mixture is cooled to about 20°C, filtered and concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 50°C. The residue obtained is purified by chromatography under a pressure of 100 kPa of nitrogen, on a column of silica gel (particle size 40-60 y; diameter 3.5 cm; height 35 cm), eluting with a dichloromethane/methanol mixture (95/0.5 by volume) and collecting 40-cm3- fractions. The fractions containing the product are combined and then purified by chromatography under a pressure of 100 kPa of nitrogen, on a column of silica gel (particle size 40-60 µ; diameter 3.5 cm; height 30 cm), eluting with an ethyl acetate/cyclohexane mixture (75/25 by volume) and collecting 30-cm3 fractions. Fractions 23 to 40 are combined and then concentrated to dryness as previously. 0.7 5 g of ethyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-(2- thiazole-2-thioethyl)piperidine-4-carboxylate is obtained. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) : 1.05 (t, J = 7 Hz: 3H); 1.38 (mt: 2H); 1.52 (mt: 2H); 1.68 (mt: 2H); from 1.90 to 2.05 (mt: 4H); 2.59 (t, J = 7 Hz: 2H); 2.68 (broad d, J = 12 Hz: 2H); 3.17 (broad t, J = 7.5 Hz: 2H); from 3.25 to 3.40 (mt: 2H); 3.97 (s: 3H); 4.00 (q, J = 7 Hz: 2H); 7.38 (d, J = 2.5 Hz: 1H); 7.46 (dd, J = 9 and 2.5 Hz: 1H); 7.63 (d, J = 3.5 Hz: 1H); 7.71 (d, J = 3.5 Hz: 1H); 7.96 (d, J = 9 Hz: 1H); 8.68 (s: 1H). Ethyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-(2-chloroethyl)piperidine-4-carboxylate 1.21 cm3 of thionyl chloride are added to a solution of 1.8 g of ethyl 4-[3-(3-chloro-6-methoxy-quinolin-4-yl)propyl]-1-(2-hydroxyethyl)piperidine-4-carboxylate in 40 cm3 of dichloromethane with stirring, at a temperature in the region of 20'°C. After stirring for 48 hours at a temperature in the region of 20°C, the reaction mixture is concentrated under reduced pressure (1 kPa) at a temperature in the region of 50°C. The residue is taken up in 50 cm3 of water and 50 cm3 of ethyl acetate with vigorous stirring at a temperature in the region of 20°C, followed by addition of 10 g of potassium carbonate. The organic phase is washed with 25 cm3- of water and then with 2 5 cm3 of saturated sodium chloride solution, dried over magnesium sulfate, filtered and concentrated under reduced pressure (1 kPa) at a temperature in the region of 50°C. 1.8 g of ethyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-(2-chloroethyl)piperidine-4-carboxylate are obtained. Infra-red Spectrum (CCI4) : 2957; 1726; 1622; 1503; 1230; 1116; 1029 and 833 cm3- Ethyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-l-(2-hydroxyethyl)piperidine-4-carboxylate 3.9 g of ethyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate and 2.07 g of potassium carbonate are added to a solution of 1.17 cm3 of 2-iodoethanol in 80 cm3 of acetonitrile, at a temperature in the region of 20°C with stirring and under an inert atmosphere. After heating for 23 hours at a temperature in the region of 80°C, a further 1.17 cm3 of 2"iodoethanol are added. After heating for 40 hours at a temperature in the region of 80°C, the reaction mixture is cooled to about 20°C, filtered and concentrated under reduced pressure (1 kPa) at a temperature in the region of 50°C. The residue obtained is purified by chromatography under a pressure of 100 kPa of nitrogen, on a column of silica gel (particle size 40-60 µ diameter 4 cm; height 60 cm), eluting with a dichloromethane/methanol/aqueous ammonia mixture (89/10/1 by volume) and collecting 50-cm3 fractions. Fractions 14 to 17 are combined and then concentrated as previously 1.9 g of ethyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-propyl]-1-(2-hydroxyethyl)piperidine-4-carboxylate are obtained. Infra-red Spectrum (CCI4) : 2439; 2952; 1726; 1622; 1503; 1230; 1116; 1029 and 833 cm3- Examnple 19 4- [3- (R, S) -Hydroxy-3- (3-chloro-6-methoxyquinolin-4-yl) -propyl] -1- [2- (cyclopentylthioethyl)piperidin-4-yl] -methanol dihydrochloride A mixture of 0.6 g of {4-[3-(3-chloro-6-methoxyquinolin-4-yl)-3-(R,S)-hydroxypropyl]piperidin-4-yljmethanol dihydrochloride, 0.24 g of l-bromo-2-(cyclopentylthio)ethyl, 0.22 g of potassium iodide and 0.9 g of potassium carbonate in 25 cm3- of acetonitrile is heated with stirring for 20 hours at a temperature in the region of 75°C. After cooling to a temperature in the region of 20°C, the reaction mixture is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue obtained is taken up in 2 0 cm3- of water and then extracted with 3 times 2 0 cm3 of ethyl acetate. The organic phases are combined, dried over magnesium sulfate, filtered and then concentrated to dryness as above. The residue obtained is purified by chromatography under a pressure of 50 kPa of nitrogen, on a column of silica gel (particle size 20-45 -µ diameter 3 cm; height: 18 cm), eluting with a dichloromethane/-methanol mixture (90/10 by volume). The fractions containing the expected product are combined and then concentrated to dryness under the above conditions. The residue obtained is taken up in 5 cm3 of acetone and then acidified with 3 cm3- of a IN solution of hydrogen chloride in diethyl ether. The suspension obtained is diluted with 2 0 cm3 of diethyl ether, stirred at a temperature in the region of 20°C for 3 hours, filtered, washed with diethyl ether and then dried in a desiccator under reduced pressure (0.1 kPa) at a temperature in the region of 40°C. 0.4 g of 4-[3-(R,S)-hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(cyclopentylthio-ethyl)piperidin-4-yl]methanol dihydrochloride is obtained in the form of a pale yellow solid melting at 120°C. 1H NMR Spectrum (400 MHz, (CD3)2SO-d6 with addition of a few drops of CD3COOD-d4 at a temperature of 373K, 5 in ppm): from 1.20 to 2.15 (mt: 16H) ; 2.93 (broad t, J = 7-5 Hz: 2H); from 3.10 to 3.30 (mt: 7H); 3.33 (broads: 2H); 3.91 (s: 3H); 5.49 (mt: 1H); 7.41 (dd, J =9 and 3 Hz: 1H); 7.93 (d, J = 9 Hz: 1H); 8.22 (d, J = 3 Hz: 1H); 8.60 (s: 1H). {4-[3-(3-Chloro-6-methoxyquinolin-4-yl)-3-(R,S)-hydroxypropyl ] piperidin-4-yl}methanol dihydrochloride A mixture of 1.5 g of tert-butyl 4-(tert-butyldimethylsilanyloxymethyl) -4- [3- (3-chloro-6-methoxy-quinolin-4-yl)-3-(R,S)-hydroxypropyl]piperidine-1-carboxylate in 6.5 cm3- of 5N hydrochloric acid dissolved in dioxane and 30 cm3 of dioxane is stirred at a temperature in the region of 20°C for 17 hours. 100 cm3 of diethyl ether are added to the reaction mixture. The precipitate formed is filtered off to give 1.24 g of {4-[3-(3-chloro-6-methoxyquinolin-4-yl)-3-(R,S)-hydroxy-propyl] piperidin-4-yl}methanol dihydrochloride in the form of a pale yellow solid. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) 1.20 to 2.10 (mt: 8H); from 2.85 to 3.10 (mt: 4H); 3.26 (broad s: 2H); 3.91 (s: 3H); 5.45 (mt: 1H); 7.47 (dd, J = 9 and 3 Hz: 1H); 7.98 (d, J = 9 Hz: 1H); 8.23 (d, J = 3 Hz: 1H) ; from 8.60 to 8.80 (unresolved pealc: 2H) ; 8-69 (s: 1H). tert-Butyl 4- (tert-butyldimethylsilauxyloxymethyl) -4- [3-{3-chloro-6-methoxyquinolin-4-yl) -3- (R,S) -hydroxy-propyl]piperidine-*l-carboxylate A solution of 5.26 g of tert-butyl 4-(tert-butyldimethylsilanyloxymethyl)-4-[3-(3-chloro-6-methoxy-quinolin-4-yl)propyl]piperidine-1-carboxylate in 300 cm3-of dimethyl sulfoxide and 7 5 cm3 of tert-butanol is stirred under an oxygen-saturated atmosphere at a temperature in the region of 20°C. After 5 minutes, a solution of 2.1 g of potassium tert-butoxide in 30 cm3 of tert-butanol is added to the reaction mixture. After sparging with oxygen for 1 and a half hours, the reaction mixture is poured carefully onto a mixture of 300 g of ice, 300 cm3 of water and 1.1 cm3 of acetic acid. The aqueous phase is extracted with 3 times 300 cm3 of dichloromethane. The organic phases are combined, washed with twice 300 cm3 of water, dried over magnesium sulfate and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue obtained is purified by chromatography under a pressure of 50 kPa of nitrogen, on a column of silica gel (particle size 20-45 µ diameter 4 cm; height: 27 cm), eluting with a cyclohexane/ethyl acetate mixture (50/50 by volume). The fractions containing the expected product are combined and then concentrated to dryness under the above conditions. 3.4 g of tert-butyl 4-(tert-butyldimethylsilanyloxymethyl)-4-[3-(3-chloro-6-methoxy-quinolin-4-yl)-3-hydroxypropyl]piperidine-l-carboxylate are obtained in the form of a white foam. Mass spectrum: EI m/z = 578 M+ m/z = 521 C26H38ClN205Si+ m/z = 465 C22H3oClN205Si+ m/z = 421 C2iH3oClN203Si+ base peak m/z = 57 C4H9- DCI m/z = 579 MH+ m/2 = 523 C26H4oClN205Si- tert-Butyl 4- (tert-butyldimethylsilanyloxymethyl) -4- [3-(3-chloro-6-methoxyquinolin-4-yl) propyl] piperidine-1-carboxylate A mixture of 0.45 g of tert-butyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-4-hydroxymethyl-piperidine-1-carboxylate, 0.3 g of tert-butyldimethyl-silyl chloride, 0.17 cm3 of triethylamine and 0.04 g of dimethylaminopyridine in 20 cm3 of dichloromethane is stirred under an inert atmosphere at a temperature in the region of 20°C. After stirring for 18 hours, 0.3 g of tert-butyldimethylsilyl chloride, 0.04 g of dimethyl-aminopyridine and 0.2 cm3 of triethylamine are added. The reaction mixture is taken up in 20 cm3 of water. The aqueous phase is extracted with twice 20 cm3- of dichloromethane. The organic phases are combined, washed with twice 300 cm3- of saturated sodium chloride solution, dried over magnesium sulfate and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue obtained is purified by chromatography under a pressure of 50 kPa of nitrogen, on a column of silica gel (particle size 20-45 µ; diameter 2.5 cm; height: 15 cm), eluting with a cyclohexane/ethyl acetate mixture (70/30 by volume). The fractions containing the expected product are combined and then concentrated to dryness under the above conditions. 0.48 g of tert-butyl 4-(tert-butyldimethyl-silanyloxymethyl) -4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]piperidine-l-carboxylate is obtained in the form of a colorless lacquer. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) : -0.04 (s: 6H); 0.76 (s: 9H); 1.29 (mt: 4H); 1.39 (s: 9H); 1.58 (mt: 4H); 3.19 (mt: 2H); from 3.20 to 3.45 (mt: 6H); 3.95 (s: 3H); 7.41 (d, J = 3 Hz: 1H); 7.45 (dd, J = 9 and 3 Hz: 1H); 7.95 (d, J = 9 Hz: 1H); 8.67 (s: 1H). tert-Butyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-4-hydroxymethylpiperidine-1-carboxylate 1.05 g of lithium aluminum hydride is added portionwise, with stirring and under an inert atmosphere, to a solution of 12.3 g of ethyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-(tert-butyloxycarbonyl)-piperidine-4-carboxylate in 250 cm3 of tetrahydrofuran, at a temperature in the region of -20°C. After stirring for 2 hours at a temperature in the region of 20°C, 0.5 g of lithium aluminum hydride is added to the reaction mixture at a temperature in the region of -2 0°C. After 1 and a half hours, the reaction mixture is cooled to 0°C and is then hydrolyzed by successive addition of 1.8 cm3 of water, 1.3 cm3 of 5N sodium hydroxide and 5.7 cm3 of water. After stirring for 30 minutes at a temperature in the region of 20°C, the reaction mixture is filtered and then washed with 400 cm3 of ethyl acetate. The filtrate is washed with 200 cm3 of saturated sodium chloride solution, dried over magnesium sulfate and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. 10.9 g of tert-butyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-4-hydroxy-methylpiperidine-1-carboxylate are obtained. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6, 6 in ppm) : 1.23 (mt: 2H); 1.32 (mt: 2H); 1.39 (s: 9H); 1.58 (mt: 4H); from 3.10 to 3.40 (mt: 6H); 3.22 (d, J = 5 Hz: 2H); 3.96 (s: 3H); 4.50 (t, J = 5 Hz: 1H); 7,40 (d, J = 3 Hz: 1H); 7.45 (dd, J = 9 and 3 Hz: 1H); 7.96 (d, J = 9 Hz: 1H); 8.68 (s: 1H). The ethyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-(tert-butyloxycarbonyl)piperidine-4-carboxylate was prepared in Example 5. Examnple 20 4- [3- (3-Chloro-6-methoxyquinolin-4-yl) -3- (R, S) - fluoropropyl]-1-(3-phenylpropyl)piperidin-4-carboxylic acid A mixture of 0.5 g of methyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-3-(R,S)-fluoropropyl]-1-(3-phenyl-propyl)piperidine-4-carboxylate in 8 cm3 of aqueous 5N hydrochloric acid is maintained at a temperature in the region of 100°C, with stirring for 6 hours. After stirring for 18 hours at a temperature in the region of 20°C, the reaction mixture is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue obtained is taken up in 10 cm3 of dichloromethane and filtered. The filtrate is concentrated to dryness as above, taken up in diisopropyl ether and then dried in a desiccator under reduced pressure (0.1 kPa) at a temperature in the region of 40°C. The residue obtained is purified by chromatography under a pressure of 60 kPa of nitrogen, on a column of silica gel (particle size 20-45 µ diameter 2,5 cm; height: 40 cm); eluting with a mixture of dichloromethane/methanol/aqueous ammonia (83/15/2). Fractions 13 to 20 are combined and then concentrated to dryness under the above conditions. 0.24 g of 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-3-(R,S)-fluoropropyl]-1-(3-phenylpropyl)piperidin-4-carboxylic acid is obtained in the form of a white solid melting at 240°C. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6, 6 in ppm) : from 1.20 to 2.35 and from 2.40 to 2.70 (mts: 18H in total); 3.94 (broad s: 3H); 6.36 (2 mts, JHF = 48 Hz: 1H); from 7.10 to 7.35 (mt: 5H); 7.52 (broad d, J = 9 Hz: 1H); 7.57 (broad s: 1H); 8.02 (broad d, J = 9 Hz: 1H); 8.75 (broad s: 1H). Methyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-3-(R,S)-fluoropropyl]-1-(3-phenylpropyl)piperidine-4-carboxylate 0 .31 cm3 of diethylaminosulfur trifluoride is added to a solution of 0.66 g of methyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-3-(R,S)-hydroxypropyl]-1-(3-phenyl-propyl)piperidine-4-carboxylate in 4 0 cm3 of dichloromethane, with stirring and under an inert atmosphere, at a temperature in the region of -15°C. After stirring for 3 hours at a temperature in the region of 20°C, 0.31 cm3 of diethylaminosulfur trifluoride is added to the reaction mixture, followed by 2 0 cm3 of saturated sodium hydrogen carbonate solution. The aqueous phase is extracted with 2 0 cm3 of dichloromethane. The organic phases are combined, washed with saturated sodium chloride solution, dried over magnesium sulfate and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue obtained is purified by chromatography under a pressure of 100 kPa of nitrogen, on a column of silica gel (particle size 20-45 \i; diameter 3.5 cm; height: 35 cm), eluting with a dichloromethane/methanol mixture (97/3). Fractions 15 to 21 are combined and then concentrated to dryness according to the above conditions. 0.5 g of methyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-3-(R,S)-fluoropropyl]-1-(3-phenylpropyl)piperidine-4-carboxylate is obtained in the form of a brown oil. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm): from 1.30 to 2.35 and from 2.50 to 2.80 (mts: 18H in total); 3.54 (s: 3H); 3.93 (s: 3H); 6.36 (ddd, JHF = 48-8.5 and 4.5 Hz: 1H); 7.19 (mt: 3H); 7.29 (broad t, J = 7.5 Hz: 2H); 7.52 (mt: 2H); 8.04 (d, J = 9 Hz: 1H); 8.75 (broad s: 1H). Methyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-3-(R,S)-hydroxypropyl]-1-(3-phenylpropyl)piperidine-4-carboxylate A mixture of 1 g of methyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl) -3-(R,S)-hydroxypropyl]piperidine-4-carboxylate, 0.58 g of l-bromo-3-phenylpropane and 0.53 g of potassium carbonate in 50 cm3- of acetonitrile is heated for 22 hours at a temperature in the region of 7 5°C, with stirring and under an inert atmosphere. After cooling to a temperature in the region of 20°C, the reaction mixture is filtered and washed with acetonitrile. The filtrate is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue obtained is purified by chromatography under a pressure of 100 kPa of nitrogen, on a colximn of silica gel (particle size 70-200 µ; diameter 3.5 cm; height: 40 cm), eluting with dichloromethane/methanol (95/05). Fractions 21 to 48 are combined and then concentrated to dryness under the above conditions. 0.7 g of methyl 4-[3-(3-chloro-6-methoxy-quinolin-4-yl)-3-(R,S)-hydroxypropyl]-1-(3-phenylpropyl)piperidine-4-carboxylate is obtained. 1H NMR Spectrum (3 00 MHz, (CD3)2SO-d6,δ in ppm) from 1.20 to 2.35 and from 2.45 to 2.75 (mts: 18H in total); 3.48 (s: 3H); 3.88 (s: 3H); 5.40 (mt: 1H); 6.07 (d, J = 4 Hz: 1H); from 7.20 to 7.25 (mt: 3H); 7.27 (broad t, J = 7.5 Hz: 2H); 7.44 (dd, J = 9 and 3 Hz: 1H); 9.96 (d, J = 9 Hz: 1H); 8.14 (d, J = 3 Hz: 1H); 8.66 (s: 1H) . The methyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-3-(R,S)-hydroxypropyl]piperidine-4-carboxylate was prepared in Example 49. Exemtple 21 Benzyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluorophenylamino)ethyl]-piperidine-4-carboxylate is prepared in the form of a yellow oil. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) from 1.35 to 1.60 (mt: 4H); 1.74 (mt: 2H); from 1.95 to 2.10 (mt: 4H); 2.40 (t, J = 7 Hz: 2H); from 2.60 to 2.75 (mt: 2H); 3.07 (mt: 2H); 3.15 (broad t, J = 7.5 Hz: 2H); 3.94 (s: 3H); 5.05 (s: 2H); 6.05 (broad t, J = 5 Hz: 1H); from 6.15 to 6.30 (mt: 3H); 7.27 (mt: 5H); 7.36 (d, J = 2.5 Hz: 1H); 7.47 (dd, J = 9 and 2.5 Hz: 1H); 7.98 (d, J = 9 Hz: 1H); 8.68 (s: 1H). 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-di£luorophenylamino)ethyl]piperidin-4-carboxylic acid A mixture of 0.73 g of benzyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluoro-phenylamino) ethyl ] piperidine-4-carboxylate in 12 cm3- of aqueous 5N hydrochloric acid is maintained at a temperature in the region of lOO°C with stirring for 3.5 hours. After cooling to about 20°C, the reaction mixture is evaporated under reduced pressure (2 kPa) at a temperature in the region of 50°C. The evaporation residue obtained is taken up in 50 cm3 of acetone and is then concentrated to dryness under the same conditions as above. The foam obtained is purified by chromatography under a pressure of 50 kPa of argon, on a column of silica gel (particle size 20-45 µ diameter 2.5 cm; height 38 cm), eluting with a mixture of chloroform/methanol/aqueous ammonia (12/3/0.5 by volume). Fractions 31 to 46 are combined and then concentrated to dryness under the same conditions as above. The powder obtained is dried in an oven under reduced pressure (0.1 kPa) at a temperature in the region of 4 0°C. 0.28 g of 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluorophenylamino)ethyl]piperidin-4-carboxylic acid is obtained in the form of a pink-white solid melting at 210°C. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) : 1.45 (broad t, J = 12.5 Hz: 2H); 1.56 (mt: 2H); 1.68 (mt: 2H); from 1.90 to 2.10 (mt: 4H); 2.41 (t, J = 6.5 Hz: 2H); 2.66 (broad d, J = 12 Hz: 2H); 3.08 (mt: 2H); 3.18 (broad t, J = 7.5 Hz: 2H); 3.97 (s: 3H); 6.08 (broad t, J = 4.5 Hz: 1H); from 6.15 to 6.30 (mt: 3H); 7.38 (d, J = 2.5 Hz: 1H); 7.45 (dd, J = 9 and 2.5 Hz: 1H); 7.96 (d, J = 9 Hz: IH: 1H); 8.68 (s: 1H). Exainple 22 4- [3- (R,S) -Hydroxy-3- {3-chloro-6-methoxyquinolin-4-yDpropyl] -1- [2- (thien-3-yl) thioethyllpiperidin-4-yl xnethanol A mixture of 0.6 g of {4-[3-(3-chloro-6-methoxyquinolin-4-yl)-3-(R,S)-hydroxypropyl]piperidin-4-yl} methanol dihydrochloride, 0.34 g of 2-(2-bromo-ethylthio)thiophene, 0.95 g of potassium carbonate and 0.23 g of potassium iodide in 25 cm3 of acetonitrile is heated for 17 hours at a temperature in the region of 80°C, with stirring and under an inert atmosphere. After cooling to a temperature in the region of 20°C, the reaction mixture is diluted with 30 cm3- of water and is then extracted with twice 30 cm3 of ethyl acetate. The organic extracts are combined, dried over magnesium sulfate, filtered and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The oil obtained is purified by chromatography under a pressure of 50 kPa of argon, on a column of silica gel (particle size 20-45 µ; diameter 3 cm; height 27 cm), eluting with a mixture of dichloromethane/-methanol (93/7 by volume). The fractions containing the product are combined and then concentrated to dryness under the above conditions. The oil obtained is acidified with 2 cm3 of IN hydrochloric ether, diluted with 20 cm3 of diethyl ether and stirred for 1 hour at a temperature in the region of 20°C. The solid is filtered off, washed with diethyl ether and then dried in an oven under reduced pressure (10 kPa) at a temperature in the region of 40°C. 0.28 g of 4-[3-(R,S)-hydroxy-3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-thien-3-yl)thioethyl]-piperidin-4-yl} methanol hydrochloride is obtained in the form of a yellow solid melting at 118°C and becoming pasty. 1H NMR Spectrum (400 MHz, (CD3)2SO-d6,δ in ppm) . A mixture of two diastereoisomers in 50/50 approximate proportions is observed. from 1.35 to 2.10 (mt: 8H); from 2.85 to 3.60 (mt: lOH); 3.86 and 3.87 (2s: 3H in total); 5.41 (mt: 1H); from 5.80 to 6.30 (broad unresolved peak: 1H); 7.10 (mt: 1H); 7.29 (mt: 1H); 7.43 (dd, J = 9 and 3 Hz: 1H); 7.70 (mt: 1H); 7.94 (d, J = 9 Hz: 1H); 8.19 (broad s: 1H); 8.64 (s: 1H); 9.48 (unresolved peak: 1H). {4-[3-(3-Chloro-6-methoxyquinolin-4-yl)-3- (R,S)-hydroxypropyl]piperidin-4-yl} methanol dihydro-chloride was prepared in Example 19. Example 23 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-1-(3-phenylpropyl)piperidine-4-carboxeuoide 15.6 cm3 of a 0,5N solution of aqueous ammonia in dioxane, 0.26 g of 1-hydroxybenzotriazole hydrate, 0.75 g of 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride and 0.55 cm3 of triethylamine are added to a mixture of 0.75 g of 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-(3-phenylpropyl)piperidine-4-carboxylic acid in the form of the sodium salt, in 2 0 cm3 of dichloromethane. The suspension obtained is stirred for 17 hours at a temperature in the region of 20°C. The reaction mixture is diluted with 25 cm3- of water and stirred, and the phases are then separated by settling. The aqueous phase is extracted with twice 25 cm3- of dichloromethane and the organic extracts are combined, washed with 25 cm3 of brine, dried over magnesium sulfate and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The evaporation residue obtained is purified by chromatography under a pressure of 50 kPa of argon, on a column of silica gel (particle size 20-45 µ; diameter 3 cm; height 21 cm), eluting with a mixture of dichloromethane/methanol (90/10 by volume). The fractions containing the product are combined and then concentrated to dryness under the above conditions. 0.22 g of 4-[3-(3- chloro-6-methoxyquinolin-4-yl)propyl]-1-(3-phenylpropyl)-piperidine-4-carboxamide is obtained in the form of a white solid melting at 160°C. 1H NMR Spectrum (400 MHz, (CD3)2SO-d6,δ in ppm) : 1.33 (broad t, J = 12 Hz: 2H); 1.53 (mt: 2H); 1.67 (mt: 4H); 1.98 (mt: 4H); 2.20 (t, J = 7.5 Hz: 2H); from 2.40 to 2.60 (mt: 4H); 3.15 (t, J = 7.5 Hz: 2H); 3.97 (s: 3H); 6.87 (s: 1H); 7.10 (s: 1H); 7.17 (mt: 1H); 7.20 (broad d, J = 7.5 Hz: 2H); 7.27 (broad t, J = 7.5 Hz: 2H); 7.37 (d, J = 2.5 Hz: 1H); 7.45 (dd, J = 9 and 2.5 Hz: 1H); 7.96 (d, J = 9 Hz: 1H); 8.68 (s: 1H). The 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-propyl]-1-(3-phenylpropyl)piperidine-4-carboxylic acid dihydrochloride was prepared in Example 4. Example 24 4- [3-(3-Chloro-6f 7-dimethoxy 26 cm3- of aqueous 5N sodium hydroxide and 2 0 cm3-of methanol are added to a solution of 1.47 g of ethyl 4-[3-(3-chloro-6,7-dimethoxyquinolin-4-yl)propyl]-1-[2-(thiophen-2-ylthio)ethyl]piperidine-4-carboxylate in 2 0 cm3 of dioxane, with stirring and at a temperature in the region of 20°C, and the mixture is then maintained at a temperature of about 70°C for 21 hours. The reaction mixture is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C- The residue obtained is purified by chromatography under a pressure of 50 kPa of argon, on a column of silica gel (particle size 40-63 -µ mass 60 g) , eluting with a mixture of dichloromethane/methanol/aqueous ammonia (12/3/0.5 by volume). Fractions 11 to 25 are combined and then concentrated to dryness under the above conditions. 1.03 g of 4-[3-(3-chloro-6,7-dimethoxyquinolin-4-yl)-propyl]-1-[2-{thiophen-2-ylthio)ethyl]piperidine-4-carboxylic acid is obtained in the form of a white solid melting at 214°C. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6, 6 in ppm) : 1,27 (very broad t, J = 12 Hz: 2H); from 1.45 to 1.75 (mt: 4H); from 1.85 to 2.10 (mt: 4H); 2.44 (mt: 2H); from 2.50 to 2.65 (mt: 2H); 2.89 (broad t, J = 7.5 Hz: 2H); 3.13 (mt: 2H); 3.93 (s: 3H); 3.96 (s: 3H); 7.02 (dd, J = 5.5 and 3.5 Hz: 1H); 7.15 (dd, J = 3.5 and 1 Hz: 1H); 7.30 (broad s: 1 H); 7.38 (broad s: 1H); 7.58 (dd, J = 5.5 and IHz: 1H); 8.58 (s: 1H). Ethyl 4-[3-(3-chloro-6,7-dimthoxyquinolin-4-yl)propyll-1-[2-(thiophen-2-ylthio)ethyl]piperidine-4-carboxylate A mixture of 1.65 g of ethyl 4-[3-(3-chloro-6,7-dimethoxyquinolin-4-yl)piperidine-4-carboxylate; 1.16 g of 2-(2-bromoethylthio)thiophene, 1.63 g of potassium carbonate and 0.685 g of potassium iodide in 50 cm3- of acetonitrile is stirred for 23 hours at a temperature in the region of 20°C. The suspension is filtered and the filtrate is then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The evaporation residue is taken up in 50 cm3 of ethyl acetate, washed with twice 50 cm3 of water and with 40 cm3- of saturated aqueous sodium chloride solution, dried over magnesium sulfate, filtered and concentrated to dryness under the above conditions. The oil obtained is purified by chromatography under a pressure of 50 kPa of argon, on a column of silica gel (particle size 40-63 µ; diameter 4 cm) , eluting with a mixture of dichloromethane/methanol/acetonitrile (95/2.5/2-5 by volume). The fractions containing the product are combined and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. 1.47 g of 4-[3-(3-chloro-6,7-dimethoxy-quinolin-4-yl)propyl]-1-[2-(thiophen-2-ylthio)ethyl]-piperidine-4-carboxylic acid are obtained in the form of an oil. 1H NMR spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) : 1.05 (t, J = 7 Hz: 3H); 1.37 (broad t, J = 12 Hz: 2H); 1.52 (mt: 2H); from 1.60 to 1.75 (mt: 2H); from 1.85 to 2.05 (mt: 4H); 2.46 (mt: 2H); 2.61 (broad d, J = 12 Hz: 2H); 2.91 (mt: 2H); 3.15 (broad t, J = 7,5 Hz: 2H); 3.95 (s: 3H); 3.97 (s: 3H); 4.00 (q, J = 7 Hz: 2H); 7.04 (dd, J = 5.5 and 3.5 Hz: 1H); 7.17 (dd, J = 3.5 and 1 Hz: 1H); 7.31 (broad s: 1H); 7.40 (broad s: 1H); 7.60 (dd, J = 5.5 and 1 Hz: 1H); 8.61 (s: 1H). Ethyl 4-[3-(3-chloro-6,7-dimethoxyquinolin-4-yl)-piperidine-4-carboxylate 3 cm3 of trifluoroacetic acid are added dropwise to a mixture of 2.05 g of ethyl 4-[3-(3-chloro-6,7-dimethoxyquinolin-4-yl)propyl]-1-(tert-butyloxycarbonyl)piperidine-4-carboxylate in 20 cm3 of dichloromethane, with stirring and at a temperature in the region of 20°C. After 2 hours, the reaction mixture is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue is taken up in 20 cm3 of water and 10 cm3- of ethyl acetate, and then extracted with twice 10 cm3 of aqueous IN hydrochloric acid solution. The aqueous phase is basified with an aqueous 30% sodium hydroxide solution until the pH is about 10, and then extracted with 3 times 30 cm3 of ethyl acetate. The organic extracts are combined, dried over magnesium sulfate, filtered and then concentrated to dryness as above. 1.65 g of ethyl 4-[3-(3-chloro-6,7-dimethoxyquinolin-4-yl)piperidine-4-carboxylate are obtained in the form of a yellow oil. Mass Spectrum: EI m/z = 420 M- m/z = 364 C19H23ClN04- m/z = 264 C14H15ClN02' m/z = 237 C12H12CINO2+ base peak m/z = 184 C1oHi8N02- Ethyl 4- [3-(3-chloro-6,7-dimethoxyquinolin-4-yl)propyll-1-(tert-butyloxycarbonyl)piperidine-4-carboxylate 21 cm3 of 0.5M 9-borabicyclo[3.3.1]nonane solution are cooled to a temperature in the region of 0°C and 2,61 g of ethyl 4-allyl-l-(tert-butyloxycarbonyl)-piperidine-4-carboxylate in 26 cm3 of tetrahydrofuran are added dropwise, with stirring and under an inert atmosphere, while maintaining the temperature at about O°C. After the addition, the temperature of the mixture is returned to about 20°C. The solution obtained is stirred for a further 4 hours at this temperature, followed by addition of 37 cm3 of dioxane, 0.19 g of palladi-umdiphenylphosphinoferrocene chloride, 3.05 g of 4-bromo-3-fluoro-6-methoxyquinoline and 5.58 g of tribasic potassium phosphate. After stirring for 24.75 hours at a temperature in the region of 60°C, the reaction mixture is cooled to about 20°C and filtered, and the filtrate is then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue obtained is taken up in 100 cm3 of ethyl acetate and 100 cm3- of water, the phases are separated by settling and the organic phase is then washed with 100 cm3- of saturated sodium chloride solution. The organic phase is dried over magnesium sulfate, filtered and concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The oil obtained is purified by chromatography. under a pressure of 50 kPa of argon, on a column of silica gel (particle size 40-63 µ; volume 690 cm3) , eluting with a dichloromethane/methanol/acetonitrile mixture (98/1/1 by volume). The fractions containing the product are combined and then concentrated to dryness according to the same conditions as above. 2.16 g of ethyl 4-[3-(3-chloro-6,7-dimethoxyquinolin-4-yl)propyl]-1-(tert-butyloxycarbonyl)piperidine-4-carboxylate are obtained in the form of a yellow gel. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6, 6 in ppm) : 1.06 (t, J = 7 Hz: 3H); from 1.25 to 1.45 (mt: 2H); 1.39 (s: 9H); 1.53 (mt: 2H); 1.69 (mt: 2H); 1.93 (broad d, J = 13.5 Hz: 2H), 2.82 (unresolved peak: 2H); 3.14 (broad t, J = 7.5 Hz: 2H); 3.69 (broad d, J = 13.5 Hz: 2H); 3.94 (s: 3H); 3.97 (s: 3H); 4.03 (q, J = 7 Hz: 2H); 7.31 (broad s: 1H); 7.40 (broad s: 1H); 8.61 (s: 1H). 4-Broino-3-chloro-6,7-dimethoxyquinoline 19 g of triphenylphosphine dibromide are added to a solution of 5.39 g of 3-chloro-4-hydroxy-6,7-dimethoxyquinoline in 27 0 cm3 of acetonitrile, with stirring and at a temperature in the region of 20°C. The reaction mixture is heated at about 80°C for 8.25 hours. After cooling to a temperature in the region of 20°C, the insoluble material is filtered off. 5.67 g of 4-bromo-3-chloro-6,7-dimethoxyquinoline are obtained in the form of a gray solid. Mass spectrum: DCI m/z = 302 MH+ 3-Chloro"4-hydroxy-6,7-dimethoxyquinoline 5.45 g of N-chlorosuccinimide are added to a solution [lacuna] of 6,7-dimethoxyquinolin-4-ol in 300 cm3 of acetic acid, with stirring and at a temperature in the region of 20°C. The reaction mixture is heated at a temperature in the region of 50°C for 6 hours. After cooling to about 20°C and stirring for 18 hours at this same temperature, the reaction mixture is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. 100 cm3 of sodium hydrogen carbonate solution are added dropwise to the evaporation residue and the suspension is then stirred for 24 hours in the region of 2 0°C. The insoluble material is filtered off and then dried in an oven under reduced pressure (20 Pa). 5.39 g of 3-chloro-4-hydroxy-6,7-dimethoxyquinoline are obtained in the form of a dark green solid. Mass spectrum: DCI m/z = 240 MH+ 6,7-Dimethoxy-4-hydroxyquinoline A mixture of 9.24 g of 4-hydroxy-6,7-dimethoxyquinoline-3-carboxylic acid in 185 cm3 of diphenyl ether is maintained, with mechanical stirring, at a temperature in the region of 250°C for 1.3 hours. After cooling the reaction mixture to about 20°C, 100 cm3- of diisopropyl ether are added. The suspension is stirred for 8 hours and filtered, and the filter cake is washed with 3 times 100 cm3 of diisopropyl ether. 7.96 g of 6,7-dimethoxyquinolin-4-ol are obtained in the form of a brown solid. Infra-red spectrum (KBr): 3242; 1605; 1548; 1500; 1273; 1239; 1220; 1075 and 822 cm3- 4-Hydroxy-6,7-dimethoxyquinoline-3-carboxylic acid 10.2 g of phosphorus pentoxide are added cautiously, with mechanical stirring, to a mixture of 21.1 g of diethyl 2-[(3,4-dimethoxyphenylamino)-methylene]malonate in 42 cm3 of nitrobenzene. The reaction mixture is maintained at a temperature in the region of 150°C for 4 hours. After cooling to about 2 0°C and stirring for 18 hours at this same temperature, 14 cm3 of water are added dropwise and the reaction mixture is then heated to about llO°C for 7 hours. After cooling to a temperature in the region of 20°C, 42 cm3- of ethyl acetate are added. The suspension is stirred under these conditions for 18 hours, the phases are then separated by settling, the organic phase is filtered and the filter cake is washed with 3 times 40 cm3- of ethyl acetate, 40 cm3 of ethanol and 40 cm3 of water. 9.25 g of 4-hydroxy-6,7-dimethoxyquinoline-3-carboxylic acid are obtained in the form of a cream-colored solid. Infra-red spectrum (KBr): 2842; 1673; 1631; 1590; 1503; 1437; 1279; 1220; 1006; 807; 586 and 357 cm-1 Diethyl 2-[(3,4-dlmethoxyphenylamino)methylene]malonate A mixture of 10 g of 3,4-dimethoxyaniline in 13.2 cm3 of diethyl ethoxymethylenemalonate is stirred for 1.5 hours at a temperature in the region of llO°C. After cooling to about 20°C, the reaction mixture is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 50°C- 21,1 g of diethyl 2-[(3,4-dimethoxyphenylamino)methylene]malonate are obtained in the form of a brown solid. Mass spectrum: DCI m/z = 324 MH"" The ethyl 4-allyl-l-{terfc-butyloxycarbonyl)-piperidine-4-carboxylate was prepared in Example 1. Example 25 4- [3- {3-Chloro-6-methoxyquinolin-4-yl) -3- (R, S) -hydroxypropyl]-1-[2-(2,5-di£luorophenylthlo)ethyl]-piperidine-4-carboxylic acid monohydrochlorlde 5 cm3 of aqueous 5N sodium hydroxide are added to a solution of 0.6 g of (R, S)-3-(3-chloro-6--methoxyquinolin-4-yl)-9-[2-(2,5-difluorophenylthio)-ethyl]-2-oxa-9-azaspiro[5.5]undecan-1-one in 50 cm3 of acetone, with stirring and at a temperature in the region of 20°C- After 2 hours, the reaction mixture is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The evaporation residue is slurried in 10 cm3 of diethyl ether and filtered, and the filter cake is washed with diethyl ether and then dried in an oven under reduced pressure (10 Pa) at a temperature in the region of 50°C. The solid is taken up in water and acidified with aqueous IN hydrochloric acid solution until the pH is equal to 3. Dichloromethane is added at a temperature in the region of 20°C with moderate stirring and the solid is then filtered off. 0.32 g of 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-3-(R,S)-hydroxypropyl]-1-[2-(2,5-difluorophenylthio)ethyl]piperidine-4-carboxylic acid monohydrochloride is obtained in the form of a white solid. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) : from 1.30 to 2.35 (mt: 8H); 2.84 (unresolved peak: 2H); from 3.05 to 3.70 (mt: 6H); 3.90 (broad s: 3H); 5.43 (unresolved peak: 1H); 6.16 (unresolved peak: 1H); 7.14 (unresolved peak: 1H); 7.33 (unresolved peak: 1H); 7.46 (mt: 2H); 7.96 (broad d, J = 9 Hz: 1H); 8.16 (broad s: 1H); 8.67 (broad s: 1H); from 10.20 to 10.60 (broad unresolved peak: 1H). 3-{3-Chloro-6-methoxyquinolin-4-yl)-9-[2-(2,5-difluorophenylthio) ethyl] -2-oxa-9-azaspiro[5.5]undecan-l-one A mixture of 1.75 g of ethyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-(R,S)-propyl]piperidine-4- carboxylate dihydrochloride, 0.95 g of 2-(2-bromoethylthio)-1,4-difluorobenzene, 0.62 g of potassium iodide and 3.11 g of potassium carbonate in 30 cm3 of acetonitrile and 20 cm3 of dimethylformamide is heated with stirring for 18 hours at a temperature in the region of 85°C. After cooling to about 20°C, the reaction mixture is filtered through Celite and the filtrate is then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue obtained is taken up in water and diethyl ether. The organic phase is dried over magnesium sulfate, filtered and then concentrated to dryness as above. The residue obtained is purified by chromatography under atmospheric pressure, on a column of silica gel (particle size 70-200 \x; diameter 4 cm) , eluting with a dichloromethane/methanol mixture (97.5/2.5 by volume). The fractions containing the product are combined and then concentrated to dryness under the above conditions. 0.6 g of 3-(3-chloro-6-methoxyquinolin-4-yl)-9-[2-(2,5-difluorophenylthio)ethyl]-2-oxa-9-azaspiro[5.5]undecan-l-one is obtained. Mass spectrum: EI m/z = 532 M- m/z = 373 C2oH22ClN203- base peak The 2-(2-bromoethylthio)-1,4-difluorobenzene was prepared in Example 14. The methyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-3-(R,S)-hydroxypropyl]piperidine-4-carboxylate was prepared in Example 49 Example 26 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-3-(R,S)- fluoropropyl]-1-[2-(3,5-difluorophenoxy)ethyl]piperidine- 4-carboxylate A mixture of 0.4 g of methyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-3-(R,S)-fluoropropyl]-1- [2-(3,5-difluorophenoxy)ethyl]piperidine-4-carboxylate in 6.6 cm3 of aqueous 5N hydrochloric acid is maintained at a temperature in the region of lOO°C with stirring for 6 hours. After cooling to about 20°C, the reaction mixture is stirred for 2 0 hours at this same temperature and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue is taken up in a dichloromethane/methanol mixture (90/10 by volume) and is then concentrated to dryness again under the above conditions. The evaporation residue is purified by chromatography under a pressure of 60 kPa of argon, on a column of silica gel (particle size 40-60 \i; diameter 2.5 cm; height 41 cm), eluting with a dichloromethane/methanol/28% aqueous ammonia mixture (83/15/2 by volume) and collecting 30-cm3 fractions. Fractions 16 to 22 are combined and then concentrated to dryness under the above conditions. The residue is slurried in 10 cm3 of diisopropyl ether, filtered and dried. 0.21 g of 4-[3-{3-chloro-6-methoxyquinolin-4-yl)-3-(R,S)-fluoropropyl]-1-[2-(3,5-difluorophenoxy)ethyl]-piperidine-4-carboxylic acid is obtained in the form of an off-white solid melting at 205°C. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) : from 1.20 to 1.70 (mt: 3H); from 1.80 to 2.40 (mt: 7H); from 2,30 to 2.80 (mt: 2H); 2.61 (t, J = 6 Hz: 2H); 3.92 (s: 3H); 4.17 (t, J = 6 Hz: 2H); 6.36 (d mt, JHF = 48 Hz: 1H); from 6.65 to 6.85 (mt: 3H); 7.51 (dd, J = 9 and 2.5 Hz: 1H); 7.55 (broad s: 1H); 8.02 (d, J = 9 Hz: 1H); 8.74 (s: 1H). Methyl 4- [3- (3-chloro-6-methoxyquinolin-4-yl) -3- (R, S) -fluoropropyl]-1-[2-(3,5-difluorophenoxy)ethyl]piperidine-4-carboxylate 0-4 cm3- of diethylaminosulfur trifluoride is added to a solution of 1.1 g of methyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-3-(R,S)-hydroxypropyl]-1-[2-(3,5-difluorophenoxy)ethyl]piperidine-4-carboxylate in 50 cm3 of dichloromethane, with stirring and under an inert atmosphere, at a temperature in the region of -10°C. After stirring for 4 hours at a temperature in the region of 20°C, 0.4 cm3- of diethylaminosulfur trifluoride is added to the reaction mixture and the mixture is then stirred for 2 0 hours at this same temperature. 20 cm3- of saturated aqueous sodium hydrogen carbonate solution are added. The aqueous phase is extracted with 25 cm3- of dichloromethane. The organic phase is washed with twice 25 cm3 of aqueous 10% (by weight) sodium chloride solution, dried over magnesium sulfate and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The oil obtained is purified by chromatography under a pressure of 100 kPa of argon, on a column of silica gel (particle size 40-60 -i; diameter 3.5 cm; height: 35 cm), eluting with a dichloromethane /methanol mixture (97/3) and collecting 35-cm3 fractions. Fractions 20 to 21 are combined and then concentrated to dryness under the above conditions, 0.62 g of methyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-3-(R,S)-fluoropropyl]-1-[2-(3,5-difluorophenoxy)ethyl]-piperidine-4-carboxylate is obtained in the form of an orange-colored oil. Infra-red spectrum: (CH2CI2) : 2953; 1725; 1622; 1599; 1504; 1466; 1234; 1152; 1117 and 837 cm3- Methyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-3-(R,S)-hydroxypropyl]-1-[2-(3,5-difluorophenoxy)ethyl]-piperidine-4-carboxylate 0-47 cm3 of thionyl chloride is added dropwise, with stirring and under an inert atmosphere, to a mixture of 1.1 g of 3-(3-chloro-6-methoxyc[uinolin-4-yl)-9-[2-(3,5-difluorophenoxy)ethyl]-2-oxa~9-azaspiro[5.5]undecan-1-one in 20 cm3- of methanol cooled to -20°C, and the mixture is then stirred for 24 hours at a temperature in the region of 20°C. The reaction mixture is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue is taken up in 30 cm3 of ethyl acetate and 15 cm3 of water. After addition of 5 g of potassium carbonate and vigorous stirring for 5 minutes, the mixture is allowed to settle and the organic phase is separated out and washed with 3 times 15 cm3 of aqueous 10% (by weight) sodium chloride solution. After drying over magnesium sulfate and then filtration, the organic solution is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40-0. 1.12 g of methyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-3-(R,S)-hydroxypropyl]-l-[2-(3,5-difluorophenoxy)ethyl]piperidine-4-carboxylate are obtained in the form of a brown lacquer. Infra-red spectrum (CCI4) : 3615; 2952; 1732; 1622; 1600; 1466; 1233; 1154; 1117; 841 and 671 cm3- 3- (3-Chloro-6-methoxyquinolin-4-yl) -9- [2- (3,5- dif luorophenoxy)ethyl] -2-oxa-9-azaspiro[5.5]undecan-l-one A mixture of 1 g of methyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-3-(R,S)-hydroxypropyl]piperidine-4-carboxylate, 0.8 g of 1-(2-bromoethoxy)-3,5-difluoro-benzene and 0.42 g of potassium carbonate in 45 cm3- of acetonitrile is maintained at a temperature of 80°C with stirring and under an argon atmosphere for 20 hours. The suspension is filtered, the insoluble material is washed with ethyl acetate and the filtrate is then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue is purified by chromatography under a pressure of 100 kPa of argon, on a column of silica gel (particle size 40-60 \x; diameter 3.5 cm; height: 38 cm), eluting with a dichloromethane/methanol mixture (97/4 by volume) and collecting 35-cm3 fractions. Fractions 9 to 20 are combined and then concentrated to dryness under the above conditions. 1.1 g of 3-(3-chloro-6-methoxyquinolin-4-yl)-9-[2-(3,5-difluorophenoxy)ethyl]-2-oxa-9-a2aspiro[5.5]-undecan-1-one are obtained. Infra-red spectrum (CCI4) : 2940; 1735; 1622; 1600; 1503; 1467; 1233; 1153; 1117; 841 and 671 cm3- The methyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-3-hydroxypropyl]piperidine-4-carboxylate was prepared in Example 49. The 1-(2-bromoethoxy)-3,5-difluorobenzene may be obtained by applying the method described in Example 16. Example 27 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-l-[2-(3,5-difluorophenoxy)ethyl]piperidine-4-carboxajnide 13.4 cm3 of a 0,5N solution of aqueous ammonia in dioxane, 0,229 g of l-hydroxybenzotriazole hydrate, 0.64 g of 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride and 0.46 cm3 of triethylamine are added, with stirring and under an inert atmosphere, to a mixture of 0.69 g of 4-[3-{3-chloro-6-methoxyquinolin-4-yl)-propyl]-1-[2-(3,5-difluorophenoxy)ethyl]piperidine-4-carboxylic acid in 30 cm3 of dichloromethane. The suspension obtained is stirred for 17 hours at a temperature in the region of 2 0°C. The reaction mixture is diluted with 50 cm3 of water, stirred and the phases are separated by settling. The aqueous phase is extracted with twice 25 cm3 of dichloromethane and the organic extracts are combined, washed with 2 5 cm3 of saturated aqueous sodium chloride solution, dried over magnesium sulfate and then concentrated to dryness under reduced pressure (2 IcPa) at a temperature in the region of 40°C. The solid is taJcen up in 20 cm3 of diisopropyl ether, stirred and then filtered. 0.52 g of 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluorophenoxy)-ethyl]piperidine-4-carboxamide i s obtained. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) : 1,34 (broad t, J = 12.5 Hz: 2H); 1.54 (mt: 2H); 1.66 (mt: 2H); 2.02 (broad d, J = 12.5 Hz: 2H); 2.12 (broad t, J = 11 Hz: 2H); from 2.55 to 2.75 (mt: 4H); 3.16 (broad t, J = 7.5 Hz: 2H); 3.97 (s: 3H); 4.08 (t, J = 6Hz: 2H); from 6.65 to 6.85 (mt: 3H); 6.91 (broad s: 1H); 7.15 (broad s: 1H); 7.37 (d, J = 3 Hz: 1H); 7.45 (dd, J = 9 and 3 Hz: 1H); 7.97 (d, J = 9 Hz: 1H); 8.68 (s: 1H). The 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-propyl]-1-[2-(3,5-difluorophenoxy)ethyl]piperidine-4-carboxylic acid was prepared in Example 2. Exainple 28 Sodium salt of 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-propyl] -1- (cinnamyl)piperidin6-4-carboxylic acid A mixture of 0.72 g of ethyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-(cinnamyl)piperidine-4-carboxylate in 14 cm3- dioxane, 14 cm3 of methanol and 14 cm3- of aqueous 5N sodium hydroxide solution is stirred at a temperature in the region of 20°C. After 2 hours, a further 14 cm3- of aqueous 5N sodium hydroxide solution are added, followed by a further 14 cm3- after a further 18 hours. The reaction mixture is maintained at a temperature in the region of 70°C for 21 hours. After cooling to about 20°C, the reaction mass is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue obtained is taken up in 15 cm3 of distilled water, filtered and then dried in the open air for 18 hours. 0-49 g of the sodium salt of sodium salt of 4-[3-(3-chloro-6-methoxy-quinolin-4-yl)propyl] -1-(cinnamyl)piperidine-4-carboxylic acid is obtained in the form of a white solid melting at about 23 0°C. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) : 1.16 (very broad t, J = 12 Hz: 2H); from 1.45 to 1.70 (mt: 4H); from 1,95 to 2.20 (mt: 4H); from 2.45 to 2.60 (mt: 2H); 2.99 (d, J = 6.5 Hz: 2H); 3.14 (broad t, J = 7 Hz: 2H); 3.99 (s: 3H); 6.28 (dt, J = 15.5 and 5.5 Hz: 1H); 6.48 (d, J = 15.5 Hz: 1H); 7.24 (broad t, J = 7.5 Hz: 1H); 7.33 (broad t, J = 7.5 Hz: 2H); from 7.40 to 7.50 (mt: 4H); 7.95 (d, J = 9 Hz: 1H); 8.66 (s: 1H). Ethyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-(cinneunyl)piperidine-4-carboxylate A mixture of 1 g of ethyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate, 0.551 g of cinnamyl bromide, 0.42 g of potassium iodide and 1.05 g of potassium carbonate in 20 cm3 of acetonitrile is stirred for 18.5 hours at a temperature in the region of 20°C. The reaction mixture is filtered and the insoluble material is rinsed with 20 cm3 of acetonitrile and with twice 30 cm3 of dichloromethane. The filtrate is dried over magnesium sulfate, filtered and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue obtained is purified by chromatography under a pressure of 50 kPa of argon, on a column of silica gel (particle size 40-53 \X; diameter 2.5 cm; mass 35 g) , eluting with a cyelohexane/ethyl acetate mixture (90/10 by volume) and then with a cyclohexane/ethyl acetate mixture (60/40 by volume) and collecting 20-cm3- fractions. The fractions containing the product are combined and then concentrated to dryness under the conditions described above. 0.72 g of ethyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-(3-phenyl-allyl)piperidine-4-carboxylate is obtained in the form of a viscous orange oil. Mass spectrum: EI m/z = 506 M+ m/z = 415 C23H28CIN2O3+' m/z = 300 C19H26N02+ m/z = 117 CgHg+ base peak The ethyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate was prepared in the form of the monohydrochloride in Example 5. Example 29 4- [3-(3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- [2-(3,5-difluorophenoxy)ethyl]plperidine-4-acetic acid A mixture of 0.18 g of methyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-l-[2-(3,5-difluorophenoxy)ethyl]piperidin-4-yl}carboxylate in 10 cm3 of dioxane, 10 cm3 of methanol and 0.99 cm3 of aqueous 5N sodiiim hydroxide solution is stirred at a temperature in the region of 75°C for 17 hours. After cooling to about 45°C, the reaction mixture is concentrated to dryness under a pressure gradually reduced to 9 kPa at a temperature in the region of 40°C. The pasty residue is taken up in 3 cm3 of chloroform/-methanol/aqueous ammonia (12/3/0.5 by volume) and the organic phase is then purified by chromatography under atmospheric pressure, on a column of silica gel (Bond Elut; particle size 70-200 -µ diameter 2 cm; mass 5 g) , eluting with a chloroform/methanol/aqueous ammonia mixture (12/3/0.5 by volume) . The fractions containing the product are combined and then concentrated to dryness under reduced pressure (5 kPa) at a temperature in the region of 40°C and the product is dried in an oven under reduced pressure (50 kPa) at a temperature in the region of 50°C. 0.15 g of 4-[3-(3-chloro-6-methoxyquinolin-4-yDpropyl] -1- [2- (3 , 5-difluorophenoxy) ethyl]piperidine-4-acetic acid is obtained. 1H NMR Spectrum (500 MHz, (CD3)2SO-d6, 5 in ppm) : 1.39 (mt: 2H); 1.50 (mt: 2H); 1.61 (mt: 4H); 2.15 (broad s: 2H); from 2.30 to 2.60 (mt: 4H); 2.63 (broad t, J = 5.5 Hz: 2H); 3.12 (unresolved peak: 2H); 3.94 (s: 3H); 4.06 (broad t, J = 5.5 Hz: 2H); from 6.65 to 6.75 (mt: 3H); 7.36 (broad s: 1H); 7.41 (broad d, J = 9 Hz: 1H); 7.93 (d, J = 9 Hz: 1H); 8.64 (s: 1H). Methyl {4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3- 5-difluorophenoxy)ethyl]piperidin-4-yl}acetate A mixture of 0.35 g of methyl {4-[3-(3-chloro-6-methoxyquinolin-4-yl )propyl]piperidin-4-yl}acetate, 0.318 g of 1-(2-bromoethoxy)-3,5-difluorobenzene, 0.15 g of potassium iodide and 0.62 g of potassium carbonate in 20 cm3 of acetonitrile is stirred for 18 hours at a temperature in the region of 70°C. After cooling to about 20°C, the reaction mixture is filtered through a silica cartridge (Bond Elut) and then rinsed with twice 2 cm3 of acetonitrile. The organic phase is concentrated to dryness under reduced pressure (2.4 kPa) at a temperature in the region of 45°C. The evaporation residue obtained is dissolved in 12 cm3 of dimethylformamide and then purified by injection of 4 times 3 cm3- per chromatography onto an SCX silica gel cartridge (mass 1 g), eluting with a gradient of from pure methanol to a mixture of 4N ammoniacal methanol. The fractions containing the product are combined and then concentrated to dryness under compressed air at a temperature in the region of 45°C. The evaporation residue obtained is taken up in dichloromethane and dried in the open air for 48 hours and then oven-dried under reduced pressure (10 kPa) at a temperature in the region of 50°C. 0.195 g of methyl {4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluorophenoxy)ethyl]piperidin-4-yl}acetate is obtained. 1H NMR Spectrum (500 MHz, (CD3)2SO-d6, at a temperature of 353 K, 5 in ppm): from 1.45 to 2.70 (mt: 16H); 3.17 (mt: 2H); 3.51 (s: 3H); 3.96 (s: 3H); 4.24 (unresolved peak: 2H); from 6.60 to 6.70 (mt: 3H); 7.38 (broad s: 1H); 7.42 (broad d, J = 9 Hz: 1H); 7.94 (d, J = 9 Hz: 1H); 8.62 (broad s: 1H). Methyl {4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -piperidin-4-yl}acetate A mixture of 17 g of tert-butyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-4-cyanomethylpiperidine-l-carboxylate in 100 cm3 of aqueous 12N hydrochloric acid (concentrated to dryness) is gradually brought to a temperature in the region of 100°C with stirring over 18 hours. The reaction mixture is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 60°C. The oil obtained is taken up in acetone and the precipitate is filtered off and washed with acetone. 20.4 g of {4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]piperidin-4-yl}acetic acid dihydrochloride are obtained in the form of a grayish solid melting at 181°C and becoming sticky. The above product is dissolved in 400 cm3 of methanol and 10 cm3- of dry concentrated sulfuric acid, stirred and heated in the region of 100°C for 1.5 hours. The reaction mixture is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 50°C. The oil obtained is taken up in 300 cm3 of water with stirring, neutralized with sodium hydrogen carbonate, basified with potassium carbonate and extracted with ethyl acetate. The organic phase is separated out after settling has taken place, washed with water, dried over magnesium sulfate, filtered and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The aqueous phase is basified to pH 8 with aqueous 5N sodium hydroxide solution and extracted with ethyl acetate, the phases are separated by settling and the organic extracts are washed, dried with magnesium sulfate and concentrated to dryness according to the conditions described above. All the organic evaporation residues are combined and purified by chromatography under a pressure of 5 0 kPa of argon, on a column of silica gel (particle size 20-43 |i; mass 200 g), eluting with a dichloromethane/methanol/aqueous ammonia mixture (40/5/0-5 by voliime) . The fractions containing the product are combined and concentrated to dryness as under the above conditions. 7.6 g of methyl {4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]piperidin-4-yl}acetate are obtained in the form of orange-colored oil. Mass spectrum: EI m/z = 390 M- m/z = 207 CuH10ClNO+ m/2 = 184 CioHisNOs" tert-Butyl 4- [3- (3-chloro-6-methoxy A mixture of 30.58 g of tert-butyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-4-methane-sulfonyloxymethylpiperidine-1-carboxylate and 15.1 g of potassium cyanide in 436 cm3 of dimethyl sulfoxide is heated with stirring at a temperature in the region of 100°C for 48 hours and is then stirred in the region of 20°C for 24 hours. 2 000 cm3 of ice-water are added to the reaction mixture, the suspension is stirred for 1 hour at a temperature in the region of 20°C and then filtered, and the filter cake is washed with 3 times 2 00 cm3 of water and then dried in the open air. The residue is purified by chromatography under a pressure of 50 kPa of argon, on a column of silica gel (particle size 20-45 |i; diameter 9 cm; height 45 cm) , eluting with a cyclohexane/ethyl acetate mixture (90/10 by volume). Fractions 40 to 100 are combined and concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 45°C. 19.25 g of tert-butyl 4-[3-(3- chloro-6-methoxyquinolin-4-yl)propyl]-4-cyanomethyl- piperidine-1-carboxylate are obtained in the form of a yellow solid melting at 160°C. Infra-red spectrum (KBr) : 2968; 2924; 2235; 1684; 1622; 1505; 1414; 1230; 1166; 1151; 826 and 738 cm-1 tert-Butyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyll-4-methanesul£onyloxymethylpiperidine-l-carboxylate A mixture of 24.8 g of tert-butyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl] -4-hydroxymethyl-piperidine-1-carboxylate in 400 cm3 of dichloromethane and 12.9 cm3 of triethylamine is cooled to about 0°C with stirring and under an inert atmosphere. Methanesulfonyl chloride, dissolved beforehand in 12 5 cm3- of dichloromethane, is added dropwise and the reaction mixture is then stirred for 18 hours at a temperature in the region of 20°C. 200 cm3- of water are added to the reaction mass, followed by a further addition of 3 000 cm3 of water. The phases are separated by settling and the aqueous phase is extracted with 200 cm3- of dichloromethane. The organic extracts are washed with 300 cm3 of aqueous sodium chloride solution, dried over sodium sulfate, filtered and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 45-0. 30.6 g of tert-butyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-4-methanesulfonyloxy-methylpiperidine-1-carboxylate are obtained in the form of an orange-colored oil. Mass spectrum: DCI m/z = 507 MH+ m/z = 431 M-CH3SO3 m/z = 397 431-Cl m/z = 375 431-tBu m/z = 331 431-BOC The 1-(2-bromoethoxy)-3,5-difluorobenzene was prepared in Example 16. The tert-butyl 4-[3-(3-chloro-6-methoxy-quinolin-4-yl)propyl]-4-hydroxymethylpiperidine-l-carboxylate was prepared in Example 19. Example 30 {4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,5-difluorophenoxy)ethyl]piperidin-4-yl}acetic acid A mixture of 0.35 g of methyl {4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,5- difluorophenoxy)ethyl]piperidin-4-yl}acetate in 10 cm3 of dioxane, 10 cm3- of methanol and 1.91 cm3 of aqueous 5N sodium hydroxide solution is stirred at a temperature in the region of 75°C for 17 hours. After cooling to about 45°C, the reaction mixture is concentrated to dryness under a pressure gradually reduced to 9 kPa at a temperature in the region of 40°C. The pasty residue is taken up in 3 cm3 of chloroform/methanol/aqueous ammonia (12/3/0.5 by volume) and the organic phase is then purified by chromatography under atmospheric pressure, on a column of silica gel (particle size 70-200 µ diameter 2 cm; mass 5 g), eluting with a chloroform/methanol/-aqueous ammonia mixture (12/3/0.5 by volume). The fractions containing the product are combined and then concentrated to dryness under reduced pressure (5 kPa) at a temperature in the region of 40°C and the product is dried in an over under reduced pressure (50 Pa) at a temperature in the region of 50°C. 0.27 g of {4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,5-difluorophenoxy)ethylIpiperidin-4-yl}acetic acid is obtained. 1H NMR Spectrum (500 MHz, (CD3)2SO-d6, 5 in ppm) : 1.39 (mt: 2H); 1.50 (mt: 2H); 1.60 (mt: 4H); 2.15 (broad s: 2H) ; from 2.30 to 2.60 (mt: 4H) ; 2.67 (t, J = 6 Hz: 2H); 3.12 (unresolved peak: 2H); 3.93 (s: 3H); 4.12 (t, J = 6 Hz: 2H); 6.72 (mt: 1H); 7.11 (mt: 1H); 7.21 (mt: 1H); 7.37 (broad s: 1H); 7.41 (broad d, J = 9 Hz: 1H); 7.93 (d, J = 9 Hz: 1H); 8.64 (s: 1H). Methyl {4-[3-(3-chloro-6-methoxyquinolin-4"yl)propyl]-1-[2-{2,5-di£luorophenoxy)ethyl]piperldin-4-yl}acetate A mixture of 0.35 g of methyl {4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]piperidin-4-yl}acetate, 0.32 g of 2-(2-bromoethoxy)-1,4-difluorobenzene, 0.15 g of potassium iodide and 0.62 g of potassium carbonate in 20 cm3 of acetonitrile is stirred for 18 hours at a temperature in the region of 70°C. After cooling to about 20°C, the reaction mixture is filtered through a silica cartridge (Bond Elut) and then rinsed with twice 2 cm3 of acetonitrile. The organic phase is concentrated to dryness under reduced pressure (2.4 kPa) at a temperature in the region of 45°C. The evaporation residue obtained in dissolved in 12 cm3 of dimethylformamide and then purified by injection of 4 times 3 cm3 per chromatography onto an SCX silica gel cartridge (mass 1 g), eluting with a gradient of from pure methanol to a mixture of 4N ammoniacal methanol. The fractions containing the product are combined and then concentrated to dryness under compressed air at a temperature in the region of 45°C. The evaporation residue obtained is taken up in dichloromethane and dried in the open air for 48 hours and then oven-dried under reduced pressure (10 Pa) at a temperature in the region of 50°C. 0.38 g of methyl {4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,5-difluorophenoxy)ethyl]piperidin-4-yl}acetate is obtained. 1H NMR Spectrum (500 MHz, (CD3)2SO-d6, 5 in ppm) : from 1.30 to 1.65 (mt: 8H); 2.25 (broad s: 2H); from 2.30 to 2.60 (mt: 4H); 2.69 (mt: 2H); 3.14 (mt: 2H); 3.47 (broad s: 3H); 3.95 (broad s: 3H); 4.12 (mt: 2H); 6.72 (mt: 1H); 7.11 (mt: 1H); 7.21 (mt: 1H); 7.38 (broads: 1H); 7.43 (broad d, J = 9 Hz: 1H); 7.94 (broad d, J = 9 Hz: 1H); 8.66 (broad s: 1H). The 2-(2-bromoethoxy)-1,4-difluorobenzene was prepared in Example 16. The methyl {4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]piperidin-4-yl}acetate was prepared in Example 29. Exaittple 31 1- (2-Cyclopentylthioethyl) -4- [3- (3-f luoro-6-methoxy-quinolin-4-yl)propyl]piperidine-4-carboxylic acid A mixture of 0.4 g of ethyl l-(2-cyclopentylthioethyl)-4-[3-(3-fluoro-6-methoxyquinolin-4 yl)propyl]piperidine-4-carboxylate in 3 cm3 of dioxane, 3 cm3 of methanol and 2.4 cm3 of aqueous 5N sodium hydroxide solution is stirred at a temperature in the region of 70°C for 17 hours. After cooling to about 20°C, the reaction mixture is concentrated to dryness under a pressure gradually reduced from 30 to 2.5 kPa and at a temperature in the region of 45°C. The residue is taken up in 5 cm3 of a dichloromethane/methanol/aqueous ammonia mixture (40/5/0.5 by volume) and is then purified by chromatography under atmospheric pressure, on a cartridge of silica gel (Bond Elut; particle size 70-200 µ mass 10 g), eluting with a dichloromethane/methanol/aqueous ammonia mixture (40/5/0.5 by volume) and then with a chloroform/methanol/aqueous ammonia mixture (13/3/0.5). The fractions containing a precipitate are combined, filtered and then washed with methanol. The solid obtained is recrystallized from 15 cm3 of boiling methanol, cooled, filtered, washed with methanol and oven-dried under reduced pressure (10 Pa) in the region of 20°C. The filtration liquors are combined and concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The liquors, once concentrated to dryness, and the solid obtained above are combined to give 0.179 g of 1-(2-cyclopentylthioethyl)-4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylic acid in the form of a white solid. 1H NIMR Spectrum (400 MHz, (CD3)2SO-d6 with addition of a few drops of CF3COOD, 5 in ppm) : 1.41 (mt: 2H); from 1.50 to 1.75 (mt: 8H); from 1.90 to 2.05 (mt: 4H); 2.20 (broad d, J = 14 Hz: 2H); from 2.75 to 2.90 (mt: 4H); from 3.10 to 3.25 (mt: 1H); 3.16 (t, J = 7 nz 2H); 3.29 (mt: 2H); 3.50 (broad d, J = 14 Hz: 2H); 3.99 (s: 3H); 7.47 (d, J = 2.5 Hz: 1H); 7.55 (dd, J = 9 and 2.5 Hz: 1H); 8.06 (d, J = 9 Hz: 1H); 8.98 (broad s: 1H) Ethyl 4- [3- (3-f luoro-6-methoxyquinoliii-4-yl)propyl] -piperidine-4-carboxylate A mixture of 0.5 g of ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate, 0.253 g of (2-chloroethylthio)cyclopentane, 0.25 g of potassium iodide and 0.92 g of potassium carbonate in 15 cm3- of acetonitrile is stirred for 18 hours at a temperature in the region of 7 0°C. After cooling to about 20°C, the reaction mixture is filtered and then rinsed with twice 3 cm3- of acetonitrile. The organic phase is concentrated to dryness under reduced pressure (2.4 kPa) at a temperature in the region of 45°C. The evaporation residue obtained is dissolved in a mixture of ethyl acetate/40-60°C petroleum ether (8/2 by volume) and is then purified by chromatography under atmospheric pressure, on a cartridge of silica gel (Bond Elut; particle size 70-200 -µ mass 10 g) , eluting with a mixture of ethyl acetate/40-60°C petroleum ether (8/2 by volume). Fractions 5 to 14 are combined and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. 0.43 g of ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4- carboxylate is obtained. 1H NMR Spectrum (500 MHz, (CD3)2SO-d6, 5 in ppm) 0.98 (t, J = 7 Hz: 3H); 1.36 (mt: 4H); from 1.40 to 1.70 (mt: 8H); from 1.80 to 2,00 (mt: 6H); from 2.30 to 2.65 (mt: 6H); 3.02 (mt: 2H); 3.09 (mt: 1H); 3.92 (s: 3H); 3.94 (q, J = 7 Hz: 2H); 7.31 (broad s: 1H); 7.37 (broad d, J = 9 Hz: 1H); 7.94 (d, J = 9 Hz: 1H); 8.66 (broad s: 1H) . The ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate was prepared in Example 11. Example 32 1-(2-Cyclohexylethyl)-4-[3-(3-fluoro-6-methoxyquiiiolin-4-yl)propyl]piperidine-4-carboxylic acid A mixture of 0.2 g of ethyl 1-(2-cyclohexyl-ethyl)-4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-piperidine-4-carboxylate in 3 cm3 of dioxane, 3 cm3 of methanol and 1.2 cm3 of aqueous 5N sodium hydroxide solution is stirred at a temperature in the region of 70°C for 22 hours. After cooling to about 20°C, the reaction mixture is evaporated under a pressure gradually reduced from 30 kPa to 2.5 kPa and at a temperature in the region of 45°C. The residue is taken up in 5 cm3 of a dichloromethane/methanol/aqueous ammonia mixture (40/5/0.5 by volume) and is then purified by chromatography under atmospheric pressure, on a cartridge of silica gel (Bond Elut; particle size 70-200 µ; mass 10 g), eluting with a dichloromethane/methanol/aqueous ammonia mixture (40/5/0.5 by volume) and then with a chloroform/methanol/aqueous ammonia mixture (13/3/0.5). The fractions containing the product are combined, concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C and dried in a desiccator (10 kPa). 0.14 g of 1-(2-cyclohexylethyl)-4-[3-{3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylic acid is obtained in the form of a white solid. 1H NMR Spectrum (400 MHz, (CD3)2SO-d6 with addition of a few drops of CF3COOD, 5 in ppm) : from 0.80 to 1.00 (mt: 2H); from 1.05 to 1.35 (mt: 5H); from 1.40 to 1.75 (mt: 12H); 2.19 (broad d, J = 14 Hz: 2H); 2.78 (broad t, J = 12.5 Hz: 2H); 3.07 (mt: 2H); 3.20 (broad t, J = 6.5 Hz: 2H); 3.45 (broad d, J = 12.5 Hz: 2H); 4.00 (s: 3H); 7.52 (d, J = 2.5 Hz: 1H); 7.60 (dd, J = 9 and 2.5 Hz: 1H); 8.10 (d, J = 9 Hz: 1H); 9.10 (d, J = 2 Hz: 1H) . Ethyl 1-(2-cyclohexylethyl)-4-[3-(3-fluoro-6-methoxy-quinolin-4-yl)propyl]piperidine-4-carboxylate A mixture of 0.4 g of ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate, 0.245 g of l-bromo-2-cyclohexylethane, 0.18 g of potassium iodide and 0.737 g of potassium carbonate in 15 cm3 of acetonitrile is stirred for 18 hours at a temperature in the region of 70°C. After cooling to about 20°C, the reaction mixture is concentrated to dryness under reduced pressure (5 kPa) at a temperature in the region of 40°C. The evaporation residue is purified by chromatography under atmospheric pressure, on a cartridge of silica gel (Bond Elut; particle size 70-200 |l; mass 12 g), eluting with a mixture of ethyl acetate/40-60°C petroleum ether (8/2 by volume). The fractions containing the product are combined and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. 0.23 g of ethyl 1-(2-cyclohexylethyl)-4- [3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate is obtained. 1H NMR Spectrum (500 MHz, (CD3)2SO-d6, 6 in ppm) : 0.84 (mt: 2H); 0.98 (t, J = 7 Hz: 3H); from 1.00 to 2.65 (mt: 25H); 3.02 (mt: 2H); 3.93 (s: 3H); 3.95 (q, J = 7 Hz: 2H); 7.31 (broad s: 1H); 7.35 (broad d, J = 9 Hz: 1H); 7.94 (d, J = 9 Hz: 1H); 8.67 (broad s: 1H). The ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate was prepared in Example 11. Exantple 33 1- {2-Cyclohexylthioethyl) -4- [3- (3-f luoro-6-methoxy-quiIlolin-4-yl)propyl]piperidine-4-carboxylic acid A mixture of 0.3 g of ethyl 1-{2-cyclohexyl-thioethyl)-4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-piperidine-4-carboxylate in 3 cm3 of dioxane, 3 cm3 of methanol and 1.7 cm3 of aqueous 5N sodium hydroxide solution is stirred at a temperature in the region of 70°C for 17 hours. After cooling to about 20°C, the reaction mixture is concentrated to dryness under a pressure gradually reduced from 30 kPa to 2.5 kPa and at a temperature in the region of 45°C. The residue is taken up in 5 cm3 of a dichloromethane/methanol/aqueous ammonia mixture (40/5/0.5 by volume) and is then purified by chromatography under atmospheric pressure, on a cartridge of silica gel (Bond Elut; particle size 70-200 µ; mass 10 g), eluting with a dichloromethane/methanol/aqueous ammonia mixture (40/5/0.5 by volume) and then with a chloroform/methanol/aqueous ammonia mixture (13/3/0.5). The fractions containing the product are combined, concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C and dried in a desiccator (10 kPa). 0.25 g of 1-(2-cyclohexylthioethyl)-4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylic acid is obtained in the form of a white solid. 1H NMR Spectrxim (400 MHz, (CD3)2SO-d6 with addition of a few drops of CF3COOD, 5 in ppm) : from 1.15 to 1.35 (mt: 5H); from 1.50 to 1.75 (mt: 8H); from 1.80 to 2.05 (mt: 3H); 2.20 (broad d, J = 14 Hz: 2H); from 2.65 to 2,90 (mt: 5H) ; 3.20 (broad t, J = 7 Hz: 2H) ; 3.25 (mt: 2H); 3.50 (broad d, J = 12 Hz: 2H); 4.00 (s: 3H); 7.50 (d, J = 2.5 Hz: 1H); 7.59 (dd, J = 9 and 2.5 Hz: 1H); 8.09 (d, J = 9 Hz: 1H); 9.07 (d, J = 2.5 Hz: 1H). Ethyl 1- (2-cyclohexylthioethyl) -4- [3- (3-f luoro-6-niethoxy-quinolin-4-yl)propyl]piperidine-4-carboxylate A mixture of 0.4 g of ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate, 0.23 g of 2-chloroethylthiocyclohexane, 0.18 g of potassium iodide and 0.74 g of potassium carbonate in 15 cm3- of acetonitrile is stirred for 18 hours at a temperature in the region of 70°C. After cooling to about 20°C, the reaction mixture is concentrated to dryness under reduced pressure (5 kPa) at a temperature in the region of 40°C. The evaporation residue is purified by chromatography under atmospheric pressure, on a cartridge of silica gel (Bond Elut; particle size 70-200 |i; mass 12 g), eluting with a mixture of ethyl acetate/40-60°C petroleum ether (8/2 by volume). The fractions containing the product are combined and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. 0.32 g of ethyl 1-(2-cyclohexylethyl)-4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate is obtained. 1H NMR Spectrum (500 MHz, (CD3)2SO-d6, 5 in ppm) : 0.97 (t, J = 7 Hz: 3H); from 1.05 to 1.70 (mt: 14H); from 1.75 to 2.00 (mt: 6H); from 2.25 to 2.60 {mt: 6H); 2.62 (mt: 1H); 3.01 (mt: 2H); 3.91 (s: 3H); 3.94 (q, J = 7 Hz: 2H); 7.30 (broad s: 1H); 7.37 (broad d, J = 9 Hz: 1H); 7.93 (d, J = 9 Hz: 1H); 8.66 (broad s: 1H). The ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate was prepared in Example 11. Exang>le 34 4-[3-{3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-(3-phenylpropyl)piperidine-4-carboxylic acid A mixture of 0.1 g of ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-(3-phenylpropyl)-piperidine-4-carboxylate in 3 cm3 of dioxane, 3 cm3 of methanol and 0.6 cm3 of aqueous 5N sodium hydroxide solution is stirred at a temperature in the region of 70°C for 17 hours. After cooling to about 20°C, the reaction mixture is concentrated to dryness under a pressure gradually reduced from 30 kPa to 2.5 kPa and at a temperature in the region of 45°C- The residue is taken up in 5 cm3- of a dichloromethane/methanol/aqueous ammonia mixture (40/5/0.5 by volume) and is then purified by chromatography under atmospheric pressure, on a cartridge of silica gel (Bond Elut; particle size 70-200 \i; mass 10 g), eluting with a mixture of dichloromethane/-methanol/aqueous ammonia (40/5/0.5 by volume) and then with a chloroform/methanol/aqueous ammonia mixture (13/3/0.5). The fractions containing the product are combined, concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C and dried in a desiccator (10 Pa). 0.25 g of 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-(3-phenylpropyl)-piperidine-4-carboxylic acid is obtained in the form of a white solid. 1H NMR Spectrum (400 MHz, (CD3)2SO-d6 with addition of a few drops of CF3COOD, 5 in ppm) : from 1.50 to 1.75 (mt: 6H); from 1.85 to 2.05 (mt: 2H); 2.19 (broad d, J = 14 Hz: 2H); 2.60 (t, J = 7.5 Hz: 2H); 2.81 (broad t, J = 12.5 Hz: 2H); 3.07 (mt: 2H); 3.20 (broad t, J = 7.5 Hz: 2H); 3.47 (broad d, J = 12.5 Hz: 2H); 3.99 (s: 3H); from 7.15 to 7.35 (mt: 5H); 7.51 (d, J = 2.5 Hz: 1H) ; 7.59 (dd, J = 9 and 2.5 Hz: 1H) ; 8.10 (d, J == 9 Hz: 1H); 9.08 (d, J = 2 Hz: 1H). Ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-l-(3-phenylpropyl)piperidine-4-carboxylate A mixture of 0.4 g of ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate, 0.2 5 g of l-bromo-3-phenylpropane, 0.181 g of potassium iodide and 0.74 g of potassium carbonate in 15 cm3 of acetonitrile is stirred for 18 hours at a temperature in the region of 70°C. After cooling to about 20°C, the reaction mixture is concentrated to dryness under reduced pressure (5 kPa) at a temperature in the region of 40°C. The evaporation residue is purified by chromatography under atmospheric pressure, on a cartridge of silica gel (Bond Elut; particle size 70-200 µ mass 12 g) , eluting with a mixture of ethyl acetate/40-60°C petroleum ether (8/2 by volume). The fractions containing the product are combined and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. 0.1 g of ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)-propyl]-1-(3-phenylpropyl)piperidine-4-carboxylate is obtained. 1H NMR Spectrum (500 MHz, (CD3)2SO-d6, 8 in ppm) : 0.97 (t, J = 7 Hz: 3H); from 1.25 to 2.00 (mt: 12H); from 2.25 to 2.70 (mt: 6H); 3.01 (mt: 2H); 3.91 (s: 3H); 3.94 (broad q, j = 7 Hz: 2H); 7.15 (mt: 3H); 7.24 (broad t, J = 7.5 Hz: 2H); 7.30 (broad s: 1H); 7.36 (broad d, J = 9 Hz: 1H); 7.93 (d, J = 9 Hz: 1H); 8.66 (broad s: 1H). The ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate was prepared in Example 11. Exainple 35 1-[2-(2,5-Difluorophenylthio)ethyl]-4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylic acid A mixture of 0.26 g of ethyl l-[2-(2,5-difluorophenylthio)ethyl]-4-[3-(3-fluoro-6-methoxy- quinolin-4-yl)propyl]piperidine-4-carboxylate in 3 cm3 of dioxane, 3 cm3 of methanol and 1.4 cm3 of aqueous 5N sodium hydroxide solution is stirred at a temperature in the region of 70°C for 17 hours. After cooling to about 20°C, the reaction mixture is concentrated to dryness under a pressure gradually reduced from 30 kPa to 2.5 kPa and at a temperature in the region of 45°C. The residue is taken up in 5 cm3 of a dichloromethane/-methanol/aqueous ammonia mixture (40/5/0,5 by volume) and is then purified by chromatography under atmospheric pressure, on a cartridge of silica gel (Bond Elut; particle size 70-200 il; mass 10 g) , eluting with a mixture of dichloromethane/methanol/aqueous ammonia (90/9/0.9 by volume) and then with a chloroform/methanol/aqueous ammonia mixture (77.5/19.5/3). The fractions containing the product are combined, concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C and dried in a desiccator (10 kPa). 0.3 g of l-[2-(2,5-difluorophenylthio)ethyl]-4-[3-(3-fluoro-6-methoxy-quinolin-4-yl)propyl]piperidine-4-carboxylic acid is obtained in the form of a white solid. 1H NMR Spectrum (400 MHz, (CD3)2SO-d6 with addition of a few drops of CF3COOD, 5 in ppm) : from 1.50 to 1.75 (mt: 6H); 2.21 (broad d, J = 14 Hz: 2H); 2.89 (broad t, J = 12.5 Hz: 2H); 3.16 (mt: 2H); from 3.25 to 3.50 (mt: 4H); 3.54 (broad d, J = 12.5 Hz: 2H); 3.99 (s: 3H); 7.14 (mt: 1H); 7.30 (doubled triplet, J = 9 and 5 Hz: 1H); 7.39 (mt: 1H); 7.47 (d, J = 2.5 Hz: 1H); 7.54 (dd, J = 9 and 2.5 Hz: 1H); 8.07 (d, J = 9 Hz: 1H); 8.97 (d, J = 2 Hz: 1H). Ethyl 1-[2-(2,5-difluorophenylthio)ethyl]-4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate A mixture of 0.4 g of ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate, 0.324 g of 2-(2-bromoethylthio)-l,4-difluorobenzene, 0.181 g of potassixim iodide and 0.74 g of potassium carbonate in 15 cm'- of acetonitrile is stirred for 18 hours at a temperature in the region of 7 0°C. After cooling to about 20°C, the reaction mixture is concentrated to dryness under reduced pressure (5 kPa) at a temperature in the region of 40°C- The evaporation residue is purified by chromatography under atmospheric pressure, on a cartridge of silica gel (Bond Elut; particle size 70-200 -µ mass 12 g) , eluting with a mixture of ethyl acetate/40-60°C petroleiim ether (8/2 by volume). The fractions containing the product are combined and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C, 0.27 g of ethyl 1-[2-(2,5-difluorophenylthio)ethyl]-4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate is obtained. 1H NMR Spectrum (500 MHz, (CD3)2SO-d6, 5 in ppm) : 0.97 (t, J = 7 Hz: 3H); 1.31 (broad t, J = 11 Hz: 2H); from 1.40 to 1.60 (mt: 4H); from 1.80 to 2.00 (mt: 4H); from 2.35 to 2.70 (mt: 4H); 3.01 (mt: 2H); 3,07 (broad t, J = 7 Hz: 2H); 3.91 (s: 3H); 3.94 (q, J = 7 Hz: 2H); 7.00 (mt: 1H); 7.21 (mt: 1H); 7.26 (mt: 1H); 7.30 (broad s: 1H); 7.37 (broad d, J = 9 Hz: 1H); 7.93 (d, J = 9 Hz: 1H); 8.66 (broad s: 1H). The ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate was prepared in Example 11. The 1-(2-bromoethylthio)-2,5-difluorobenzene was prepared in Example 14. Example 36 1-[2-(2,5-Difluorophenoxy)ethyl]-4-13-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylic acid A mixture of 0.38 g of ethyl l-[2-(2,5-difluorophenoxy)ethyl]-4-[3-(3-fluoro-6-methoxyquinolin-' 4-yl)propyl]piperidine-4-carboxylate in 3 cm3 of dioxane, 3 cm3- of methanol and 2.1 cm3 of aqueous 5N sodium hydroxide solution is stirred at a temperature in the region of 70°C for 17 hours. After cooling to about 20°C, the reaction mixture is concentrated to dryness under a pressure gradually reduced from 30 kPa to 2.5 kPa and at a temperature in the region of 45°C. The residue is taken up in 5 cm3 of a dichloromethane/methanol/aqueous ammonia mixture (40/5/0.5 by volume) and is then purified by chromatography under atmospheric pressure, on a cartridge of silica gel (Bond Elut; particle size 70-200 µ mass 10 g), eluting with a dichloromethane/methanol/aqueous ammonia mixture (90/9/0.9 by volume) and then with a chloroform/methanol/aqueous ammonia mixture (77.5/19-5/3). The fractions containing the product are combined, concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C and dried in a desiccator (10 kPa). 0.36 g of l-[2-(2,5-difluorophenoxy)ethyl]-4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylic acid is obtained in the form of a white solid. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6, 5 in ppm) : 1.32 (broad t, J = 13 Hz: 2H); from 1.50 to 1.70 (mt: 4H); 1.96 (broad d, J = 13 Hz: 2H); 2.09 (broad t, J = 11.5 Hz: 2H); 2.64 (t, J = 6 Hz: 2H); 2.70 (broad d, J = 11.5 Hz: 2H); 3.05 (very broad t, J = 6.5 Hz: 2H); 3.96 (s: 3H); 4.13 (t, J = 6 Hz: 2H); 6.75 (mt: 1H); 7.14 (mt: 1H); 7.24 (mt: 1H); 7.34 (d, J = 2.5 Hz: 1H); 7.41 (dd, J = 9 and 2.5 Hz: 1H); 7.97 (d, J = 9 Hz: 1H); 8.69 (broad s: 1H). Ethyl l-[2-(2,5-difluorophenoxy)ethyl]-4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate A mixture of 0.4 g of ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate, 0.30 g of 2-(2-bromoethoxy)-1,4-difluorobenzene, 0.181 g of potassium iodide and 0.74 g of potassium carbonate in 15 cm3 of acetonitrile is stirred for 18 hours at a temperature in the region of 70°C. After cooling to about 20°C, the reaction mixture is concentrated to dryness under reduced pressure (5 kPa) at a temperature in the region of 40°C. The evaporation residue is purified by chromatography under atmospheric pressure, on a cartridge of silica gel (Bond Elut; particle size 70-200 )Li; mass 12 g), eluting with a mixture of ethyl acetate/40-60°C petroleum ether (8/2 by volume). The fractions containing the product are combined and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. 0.4 g of ethyl l-[2-(2,5-difluorophenoxy)ethyl]-4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate is obtained. ^H NMR Spectrum (500 MHz, (CD3)2SO-d6, 5 in ppm) : 0.97 (t, J = 7 Hz: 3H); 1.36 (broad t, J = 11.5 Hz: 2H); from 1.40 to 1.60 (mt: 4H); from 1.80 to 2.10 (mt: 4H); 2.61 (broad t, J = 5.5 Hz: 2H); 2.69 (broad d, J = 11 Hz: 2H); 3.02 (mt: 2H); 3.92 (s: 3H); 3.94 (q, J = 7 Hz: 2H); 4.09 (mt: 2H); 6.71 (mt: IH); 7.10 (mt: IH); 7.19 (mt: IH); 7.29 (broad s: IH); 7.37 (broad d, J = 9 Hz: IH); 7.93 (d, J = 9 Hz: IH); 8.66 (broad s: IH). The ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate was prepared in Example 11. The 2-(2-bromoethoxy)-1, 4-dif luorobenzene was prepared in Example 16. Example 37 4- [3- (3-Fluoro'-6-methoxyquinolin-4-yl)propyl] -1- [2-(2,3,5-trifluorophenoxy)ethyl]piperidine-4-carboxylic acid A mixture of 0.42 g of ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluoro-phenoxy) ethyl ]piperidine-4-carboxylate in 3 cm3 of dioxane, 3 cm3 of methanol and 2.3 cm3 of aqueous 5N sodium hydroxide solution is stirred at a temperature in the region of 70°C for 17 hours. After cooling to about 20°C, the reaction mixture is concentrated to dryness under a pressure gradually reduced from 30 kPa to 2.5 kPa and at a temperature in the region of 45°C. The residue is taken up in 5 cm3 of a dichloromethane/methanol/-aqueous ammonia mixture (40/5/0.5 by volume) and is then purified by chromatography under atmospheric pressure, on a cartridge of silica gel (Bond Elut; particle size 70-2 00 µ mass 10 g) , eluting with a dichloromethane/-methanol/aqueous ammonia mixture (90/9/0.9 by volume) and then with a chloroform/methanol/aqueous ammonia mixture (77.5/19.5/3). The fractions containing the product are combined, concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40^C and dried in a desiccator (10 kPa). 0.39 g of 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,3,5-trifluoro-phenoxy)ethyl]piperidine-4-carboxylic acid is obtained in the form of a white solid. ^H NMR Spectrum (300 MHz, (CD3)2SO-d6, 5 in ppm) : 1.32 (very broad t, J = 12.5 Hz: 2H); 1.60 (mt: 4H); 1.95 (broad d, J = 12.5 Hz: 2H); 2.09 (broad t, J = 11 Hz: 2H); 2.64 (t, J = 5.5 Hz: 2H); 2.70 (broad d, J = 11 Hz: 2H); 3.04 (very broad t, J = 6 Hz: 2H); 3.96 (s: 3H); 4.16 (t, J = 5.5 Hz: 2H); from 6.95 to 7.15 (mt: 2H); 7.34 (d, J = 2.5 Hz: IH); 7.40 (dd, J = 9 and 2.5 Hz: IH); 7.96 (d, J = 9 Hz: IH); 8.69 (broad s: IH). Ethyl 4-[3-(3-fluoro-6-methoxy A mixture of 0.4 g of ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate, 0.33 g of 1-(2-bromoethoxy)-2,3,5-trifluorobenzene, 0.181 g of potassium iodide and 0.74 g of potassium carbonate in 15 cm3 of acetonitrile is stirred for 18 hours at a temperature in the region of 7 0°C. After cooling to about 20°C, the reaction mixture is concentrated to dryness under reduced pressure (5 kPa) at a temperature in the region of 40°C. The evaporation residue is purified by chromatography under atmospheric pressure, on a cartridge of silica gel (Bond Elut; particle size 70-200 [i; mass 12 g; volume 25 cm3) , eluting with a mixture of ethyl acetate/40-60^C petroleum ether (8/2 by volume). The fractions containing the product are combined and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40^C. 0.43 g of ethyl 4-[3-(3-fluoro-6-methoxy-quinolin-4-yl)propyl]-1-[2-(2,3,5-trifluorophenoxy)-ethyl]piperidine-4-carboxylate is obtained. ^H NMR Spectrum (500 MHz, (CD3)2SO-d6, 6 in ppm) : 0.98 (t, J = 7 Hz: 3H); 1.34 (broad t, J = 11.5 Hz: 2H); from 1.45 to 1.60 (mt: 4H); from 1.85 to 2.10 (mt: 4H); from 2.50 to 2.70 (mt: 4H); 3.02 (mt: 2H); 3.92 (s: 3H); 3.94 (q, J = 7 Hz: 2H); 4.14 (mt: 2H); 7.02 (mt: 2H); 7.30 (broad s: IH); 7.37 (broad d, J = 9 Hz: IH); 7.94 (d, J = 9 Hz: IH); 8.65 (broad s: IH). The ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate was prepared in Example 11. The 1-(2-bromoethoxy)-2,3,5-trifluorobenzene was prepared as described in Example 13. Example 38 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-heptylpiperidine-4-carboxylic acid A mixture of 0.16 g of ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-l-heptylpiperidine-4-carboxylate in 3 cm3 of dioxane, 3 cm3 of methanol and 1 cm3 of aqueous 5N sodium hydroxide solution is stirred at a temperature in the region of 70°C for 17 hours. After cooling to about 20°C, the reaction mixture is concentrated to dryness under a pressure gradually reduced from 30 kPa to 2.5 kPa and at a temperature in the region of 45°C. The residue is taken up in 5 cm3 of a dichloromethane/methanol/aqueous ammonia mixture (40/5/0.5 by volume) and is then purified by chromatography under atmospheric pressure, on a cartridge of silica gel (Bond Elut; particle size 70-200 µ mass 10 g), eluting with a dichloromethane/methanol/aqueous ammonia mixture (40/5/0.5 by volume) and then with a chloroform/methanol/aqueous ammonia mixture (13/3/0.5). The fractions containing the product are combined, concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C and dried in a desiccator (10 kPa). 0.07 g of 4-[3-(3-fluoro-6-methoxy-quinolin-4-yl) propyl]-l-heptylpiperidine-4-carboxylic acid is obtained in the form of a white solid. 1H NMR Spectrum (400 MHz, (CD3) 2SO-d6 with addition of a few drops of CF3COOD, 6 in ppm): 0.85 (t, J =7 Hz: 3H); from 1.15 to 1.35 (mt: 8H); from 1.50 to 1.75 (mt: BH); 2.19 (broad d, J = 14 Hz: 2H); 2.78 (broad t, J = 12.5 Hz: 2H); 3.02 (mt: 2H); 3.19 (broad t, J = 7 Hz: 2H); 3.45 (broad d, J = 12.5 Hz: 2H); 4.00 (s: 3H); 7.50 (d, J = 2.5 Hz: 1H); 7.58 (dd, J = 9 and 2.5 Hz: 1H); 8.09 (d, J = 9 Hz: 1H); 9.04 (d, J = 2 Hz: 1H). Ethyl 4- [3- (3-f luoro-6-methoxyquinolin-4-yl)propyl] -1-heptylpiperidine-4-carboxylate A mixture of 0.4 g of ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate, 0.2 3 g of 1-bromoheptane, 0.18 g of potassium iodide and 0.737 g of potassiiom carbonate in 15 cm3 of acetonitrile is stirred for 18 hours at a temperature in the region of 70°C. After cooling to about 20°C, the reaction mixture is concentrated to dryness under reduced pressure (5 kPa) at a temperature in the region of 40µC. The evaporation residue is purified by chromatography under atmospheric pressure, on a cartridge of silica gel (particle size 70-200 µ mass 12 g) , eluting with a mixture of ethyl acetate/40-60°C petroleum ether (8/2 by volume). The fractions containing the product are combined and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40^C. 0.2 g of ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-heptylpiperidine-4-carboxylate is obtained, 1H NMR Spectrum (500 MHz, (CD3)2SO-d6,δ in ppm) : 0.84 (t, J = 7 Hz: 3H); 0.98 (t, J = 7 Hz: 3H); from 1.10 to 1.30 (mt: 8H); 1.33 (mt: 4H); from 1.40 to 1.60 (mt: 4H); 1.83 (broad t, J = 11 Hz: 2H); 1.93 (broad d, J = 13 Hz: 2H); 2.13 (mt: 2H); from 2.35 to 2.55 (mt: 2H); 3.01 (mt: 2H); 3.89 (s: 3H); 3.94 (mt: 2H); 7,31 (broad s: 1H); 7.37 (broad d, J = 9 Hz: 1H); 7.94 (d, J = 9 Hz: 1H); 8.67 (broad s: 1H). The ethyl 4- [3- (3-f luoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate was prepared in Example 11. Example 39 4- [3- (3-Pluoro-6-methoxyquinolin-4-yl)propyl] -1- (2-phenylthioethyl)piperidine-4-carboxylic acid A mixture of 0.39 g of ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-(2- phenylthioethyl)piperidine-4-carboxylate in 3 cm3 of dioxane, 3 cm3 of methanol and 2.3 cm3 of aqueous 5N sodium hydroxide solution is stirred at a temperature in the region of 70°C for 17 hours. After cooling to about 20°C, the reaction mixture is concentrated to dryness under a pressure gradually reduced from 30 kPa to 2.5 kPa and at a temperature in the region of 45°C. The residue is taken up in 5 cm3 of a dichloromethane/-methanol/aqueous ammonia mixture (40/5/0.5 by volume) and is then purified by chromatography under atmospheric pressure, on a cartridge of silica gel (Bond Elut; particle size 70-200 µ; mass 10 g) , eluting with a dichloromethane/methanol/aqueous ammonia mixture (90/9/0.9 by volume) and then with a chloroform/methanol/aqueous ammonia mixture (77.5/19.5/3). The fractions containing the product are combined, concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40µC and dried in a desiccator (10 kPa). 0.3 g of 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-(2-phenylthio-ethyl)piperidine-4-carboxylic acid is obtained in the form of a white solid. 1H NMR Spectrum (400 MHz, (CD3)2SO-d6 with addition of a few drops of CF3COOD, 8 in ppm) : from 1.50 to 1.75 (mt: 6H); 2.20 (broad d, J = 14 Hz: 2H); 2.87 (broad t, J = 13 Hz: 2H); 3.16 (mt: 2H); 3.41 (s: 4H); 3.53 (broad d, J = 13 Hz: 2H); 4.00 (s: 3H); 7.25 (broad t, J = 7.5 Hz: 1H); from 7.30 to 7.45 (mt: 4H); 7.48 (d, J = 2.5 Hz: 1H); 7.54 (dd, J = 9 and 2.5 Hz: 1H); 8.07 (d, J = 9 Hz: 1H); 8.97 (d, J = 2 Hz: 1H). Ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-l-(2-phenylthioethyl)piperidine-4-carboxylate A mixture of 0.4 g of ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate, 0.28 g of 2-bromoethyl phenyl sulfide, 0.181 g of potassium iodide and 0.74 g of potassium carbonate in 15 cm3 of acetonitrile is stirred for 18 hours at a temperature in the region of 7 0°C. After cooling to about 20^C, the reaction mixture is concentrated to dryness under reduced pressure (5 kPa) at a temperature in the region of 40^C. The evaporation residue is purified by chromatography under atmospheric pressure, on a cartridge of silica gel (Bond Elut; particle size 70-200 \i; mass 12 g), eluting with a mixture of ethyl acetate/40-60°C petroleum ether (8/2 by volume). The fractions containing the product are combined and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. 0.4 g of ethyl 4-[3-(3-fluoro-6-methoxy-quinolin-4-yl)propyl]-1-(2-phenylthioethyl)piperidine-4-carboxylate is obtained. 1H NMR Spectrum (500 MHz, (CD3)2SO-d6,δ in ppm) : 0.97 (t, J = 7 Hz: 3H); 1.33 (broad t, J = 12.5 Hz: 2H); from 1.45 to 1.65 (mt: 4H); from 1.85 to 2.00 (mt: 4H); from 2.30 to 2.70 (mt: 4H); 3.01 (mt: 4H); 3.92 (s: 3H); 3.94 (mt: 2H); 7.15 (mt: 1H); from 7.20 to 7.35 (mt: 5H); 7.37 (broad d, J = 9 Hz: 1H); 7.93 (d, J = 9 Hz: 1H); 8.66 (broad s: 1H). The ethyl 4-[3-(3-fluoro-5-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate was prepared in Example 11. Exeunple 40 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1- [2-(3-fluorophenylthio)ethyl]piperidine-4-carboxylic acid A mixture of 0.2 g of ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-(2-phenylthioethyl)-piperidine-4-carboxylate in 3 cm3 of dioxane, 3 cm3 of methanol and 1.1 cm3 of aqueous 5N sodium hydroxide solution is stirred at a temperature in the region of 70^C for 17 hours. After cooling to about 20°C, the reaction mixture is concentrated to dryness under a pressure gradually reduced from 30 kPa to 2,5 kPa and at a temperature in the region of 45°C. The residue is taken up in 5 cm3 of a dichloromethane/methanol/aqueous ammonia mixture (40/5/0.5 by volume) and is then purified by chromatography under atmospheric pressure, on a cartridge of silica gel (Bond Elut; particle size 70-200 \i; mass 10 g), eluting with a dichloromethane/methanol/aqueous ammonia mixture (90/9/0.9 by volume) and then with a chloroform/methanol/aqueous ammonia mixture (77.5/19.5/3). The fractions containing the product are combined, concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C and dried in a desiccator (10 kPa). 0.18 g of 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3-fluorophenyl-thio)ethyl]piperidine-4-carboxylic acid is obtained. 1H NMR Spectriom (400 MHz, (CD3)2SO-d6 with addition of a few drops of CF3COOD, 5 in ppm) : from 1.50 to 1.75 (mt: 6H); 2.20 (broad d, J = 14 Hz: 2H); 2.89 (broad t, J = 12.5 Hz: 2H); 3.18 (mt: 2H); from 3.25 to 3.45 (mt: 4H); 3.54 (broad d, J = 12.5 Hz: 2H); 3,99 (s: 3H); 7.05 (doubled triplet, J = 9 and 2.5 Hz: 1H); from 7.15 to 7.30 (mt: 2H); 7.38 (mt: 1H); 7.48 (d, J = 2.5 Hz: 1H); 7.55 (dd, J = 9 and 2.5 Hz: 1H); 8.08 (d, J = 9 Hz: 1H); 9.00 (d, J = 2 Hz: 1H). Ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-(2-phenylthioethyl)piperidine-4-carboxylate A mixture of 0.4 g of ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate, 0.30 g of 3-fluoro-2-bromoethyl phenyl sulfide, 0.18 g of potassium iodide and 0.74 g of potassium carbonate in 15 cm3 of acetonitrile is stirred for 18 hours at a temperature in the region of 70^C. After cooling to about 2 0^C, the reaction mixture is concentrated to dryness under reduced pressure (5 kPa) at a temperature in the region of 40°C. The evaporation residue is purified by chromatography under atmospheric pressure of argon, on a cartridge of silica gel (Bond Elut; particle size 70-200 |X; mass 12 g) , eluting with a mixture of ethyl acetate/40-60°C petroleum ether (8/2 by volume). The fractions containing the product are combined and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40^C. 0.22 g of ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-(2-phenyl-thioethyl)piperidine-4-carboxylate is obtained. 1H NMR Spectrum (500 MHz, (CD3)2SO-d6,δ in ppm) : 0.98 (t, J = 7 Hz: 3H); 1.33 (broad t, J = 12 Hz: 2H); from 1.45 to 1.65 (mt: 4H); from 1.85 to 2.00 (mt: 4H); from 2.30 to 2.70 (mt: 4H); 3.02 (mt: 2H); 3.07 (t, J = 6.5 Hz: 2H); 3.92 (s: 3H); 3.94 (q, J = 7 Hz: 2H); 6.94 (broad t, J = 8.5 Hz: 1H); from 7.05 to 7.20 (mt: 2H); from 7.25 to 7.35 (mt: 2H); 7.37 (broad d, J = 9 Hz: 1H); 7.94 (d, J = 9 Hz: 1H); 8.66 (broad s: 1H). The ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl) propyl]piperidine-4-carboxylate was prepared in Example 11. The 3-fluoro-2-bromoethyl phenyl sulfide was prepared according to the method described in Example 14. Exaigple 41 l-[2-(3,4-Difluorophenoxy)ethyl]-4-[3-(3-fluoro-6-inethoxyquinolin-4-yl)propyl]piperidine-4-carboxylic acid A mixture of 0.38 g of ethyl l-[2-(3,4-difluorophenoxy)ethyl]-4-[3-(3-fluoro*6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate in 3 cm3 of dioxane, 3 cm3 of methanol and 2.1 cm3 of aqueous 5N sodi-um hydroxide solution is stirred at a temperature in the region of 70°C for 17 hours. After cooling to about 20°C, the reaction mixture is concentrated to dryness under a pressure gradually reduced from 30 kPa to 2.5 kPa and at a temperature in the region of 45°C. The residue is taken up in 5 cm3 of a dichloromethane/methanol/aqueous ammonia mixture (40/5/0.5 by volume) and is then purified by chromatography under atmospheric pressure, on a cartridge of silica gel (Bond Elut; particle size 70-200 \i; mass 10 g), eluting with a mixture of dichloromethane/-methanol/aqueous ammonia (90/9/0.9 by volume) and then with a chloroform/methanol/aqueous ammonia mixture (77.5/19.5/3). The fractions containing the product are combined, concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C and dried in a desiccator (10 kPa). 0.3 g of 1-[2-(3,4-difluoro-phenoxy)ethyl]-4-[3-(3-fluoro-6-methoxyquinolin-4-yl)-propyl]piperidine-4-carboxylic acid is obtained in the form of a white solid. 1H NMR Spectrum (400 MHz, (CD3)2SO-d6 with addition of a few drops of CF3COOD, 8 in ppm) : from 1.50 to 1.75 (mt: 6H); 2.21 (broad d, J = 14 Hz: 2H); 2.96 (broad t, J = 13 Hz: 2H); 3.19 (broad t, J = 6.5 Hz: 2H); from 3.50 to 3.65 (mt: 4H); 4.00 (s: 3H); 4.31 (t, J = 5.5 Hz: 2H); 6.82 (mt: 1H); 7.11 (mt: 1H); 7.35 (mt: 1H); 7.50 (d, J = 2.5 Hz: 1H); 7.57 (dd, J = 9 and 2.5 Hz: 1H) ; 8.09 (d, J = 9 Hz: 1H) ; 9.03 (d, J = 2 Hz: 1H) . Ethyl 1-[2-(3,4-difluorophenoxy)ethyl]-4-[3-(3-fluoro-6-inethoxyquinolin-4-yl)propyl]piperidine-4-carboxylate A mixture of 0.4 g of ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate, 0.3 g of 4-(2-bromoethoxy)-1,2-difluorobenzene, 0.18 g of potassium iodide and 0.74 g of potassium carbonate in 15 cm3^ of acetonitrile is stirred for 18 hours at a temperature in the region of 7 0°C. After cooling to about 20°C, the reaction mixture is concentrated to dryness under reduced pressure (5 kPa) at a temperature in the region of 40°C. The evaporation residue is purified by chromatography under atmospheric pressure, on a cartridge of silica gel (Bond Elut; particle size 70-200 ^i; mass 12 g), eluting with a mixture of ethyl acetate/40-60^C petroleum ether (8/2 by voliome) . The fractions containing the product are combined and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40^C. 0.4 g of ethyl l-[2-(3,4-difluorophenoxy)ethyl]-4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate is obtained. 1H NMR Spectrum (500 MHz, (CD3)2SO-d6,δ in ppm) : 0.98 (t, J = 7 Hz: 3H); 1.36 (broad t, J = 12 Hz: 2H); from 1.45 to 1.65 (mt: 4H); 1.93 (broad d, J = 12 Hz: 2H); 2.00 (broad t, J = 11.5 Hz: 2H); from 2.40 to 2.70 (mt: 4H); 3.02 (mt: 2H); 3.92 (s: 3H); 3.94 (q, J = 7 Hz: 2H); 3.99 (mt: 2H); 6.73 (mt: 1H); 7.03 (mt: 1H); from 7.25 to 7.35 (mt: 2H); 7.37 (broad d, J = 9 Hz: 1H); 7.93 (d, J = 9 Hz: 1H); 8.66 (broad s,: 1H). 4- (2-Broinoethoxy) -l,2-di£luorobenz6ne A mixture of 15 g of 3,4-difluorophenol, 23.5 g of potassium carbonate and 60 cm3 of 1,2-dibromoethane in 250 cm3 of acetonitrile is stirred at a temperature in the region of 70°C for 18 hours. After cooling to about 20°C, the reaction mixture is filtered through Celite and then concentrated to dryness under reduced pressure (2 ]cPa) at a temperature in the region of 40°C. The residue obtained is purified by chromatography under atmospheric pressure, on a colximn of silica gel (particle size 70-200 |l; diameter 8 cm; mass 400 g) , eluting with 40-60°C petroleum ether. The fractions containing the product are combined and then concentrated to dryness under reduced pressure (2 kPa) in the region of 40*°C. 15.7 g of 4-(2-bromoethoxy)-1,2-difluorobenzene are obtained in the form of an oil. Infra-red spectrum (CCI4) : 1609; 1516; 1264; 1253; 1215; 1206; 1162; 1019; 854 and 834 cm3. The ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate was prepared in Example 11. Exeonple 42 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-(2-phenoxYethyl)piperidine-4-carboxylic acid A mixture of 0.39 of ethyl 4-[3-(3-fluoro-6~ methoxyquinolin-4-yl)propyl]-1-(2-phenoxyethyl)-piperidine-4-carboxylate in 3 cm3 of dioxane, 3 cm3 of methanol and 2.4 cm3 of aqueous 5N sodium hydroxide solution is stirred at a temperature in the region of 70°C for 17 hours. After cooling to about 20°C, the reaction mixture is concentrated to dryness under a pressure gradually reduced from 30 kPa to 2.5 kPa and at a temperature in the region of 45°C. The residue is taken up in 5 cm3 of a dichloromethane/methanol/aqueous ammonia mixture (40/5/0.5 by volume) and is then purified by chromatography under atmospheric pressure, on a cartridge of silica gel (Bond Elut; particle size 70-200 ^; mass 10 g), eluting with a mixture of dichloromethane/methanol/aqueous ammonia (90/9/0.9 by volume) and then with a chloroform/methanol/aqueous ammonia mixture (77.5/19.5/3). The fractions containing the product are combined, concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C and dried in a desiccator (10 kPa). 0.33 g of 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-(2-phenoxyethyl)piperidine-4-carboxylic acid is obtained in the form of a white solid. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6 with addition of a few drops of CF3COOD, 6 in ppm) : 1.36 (broad t, J = 12.5 Hz: 2H); from 1.50 to 1.70 (mt: 4H); 1.96 (broad d, J = 12.5 Hz: 2H); 2.08 (broad t, J = 11.5 Hz: 2H); 2.62 (t, J = 6 Hz: 2H); 2.71 (broad d, J = 11.5 Hz: 2H); 3.05 (broad t, J = 6.5 Hz: 2H); 3.97 (s: 3H); 4.03 (t, J = 6 Hz: 2H); from 6.85 to 7.00 (mt: 3H); 7.29 (broad t, J = 8 Hz: 2H); 7.35 (d, J = 2.5 Hz: 1H); 7.40 (dd, J = 9 and 2.5 Hz: 1H); 7.97 (d, J = 9 Hz: 1H); 8.70 (broad s: 1H). Ethyl 4-[3-(3-fluoro-6-inethoxyquinolin-4-yl)propyll-1-(2-phenoxyethyl)piperidine-4-carboxylate A mixture of 0.4 g of ethyl 4-[3-(3-fluoro-6- methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate, 0.26 g of 2-broinoethyl phenyl ether, 0.181 g of potassiiim iodide and 0.131 g of potassium carbonate in 15 cm3 of acetonitrile is stirred for 18 hours at a temperature in the region of 70°C. After cooling to about 20°C, the reaction mixture is concentrated to dryness under reduced pressure (5 kPa) at a temperature in the region of 40^C. The evaporation residue is purified by chromatography under atmospheric pressure, on a cartridge of silica gel (Bond Elut; particle size 70-200 \i; mass 12 g) , eluting with a mixture of ethyl acetate/40-60°C petroleum ether (8/2 by volume). The fractions containing the product are combined and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40*°C. 0.4 g of ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)-propyl]-1-(2-phenoxyethyl)piperidine-4-carboxylate is obtained. 1H NMR Spectrum (500 MHz, (CD3)2SO-d6,δ in ppm) : 0.99 (t, J = 7 Hz: 3H); 1.37 (mt: 2H); from 1.45 to 1.65 (mt: 4H); from 1.85 to 2.10 (mt: 4H); from 2.35 to 2.75 (mt: 4H); 3.03 (mt: 2H); 3.93 (s: 3H); 3.96 (q, J = 7 Hz: 2H); 4.02 (mt: 2H); 6.90 (mt: 3H); 7.26 (broad t, J = 7.5 Hz: 2H); 7.32 (broad s: 1H); 7.38 (broad d, J = 9 Hz: 1H); 7.95 (d, J = 9 Hz: 1H); 8.68 (broad s: 1H). The ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate was prepared in Example 11. Example 43 4-[3-(3-Fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3-fluorophenoxy)ethyl]piperidine-4-carboxylic acid A mixture of 0.415 g of ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3-fluorophenoxy)-ethylJpiperidine-4-carboxylate m 3 cm of dioxane, 3 cm of methanol and 2.4 cm3 of aqueous 5N sodium hydroxide solution is stirred at a temperature in the region of 70°C for 17 hours. After cooling to about 20°C, the reaction mixture is concentrated to dryness under a pressure gradually reduced from 30 kPa to 2.5 kPa and at a temperature in the region of 45^C. The residue is taken up in 5 cm3 of a dichloromethane/methanol/aqueous ammonia mixture (40/5/0.5 by volume) and is then purified by chromatography under atmospheric pressure, on a cartridge of silica gel (Bond Elut; particle size 70-200 [i; mass 10 g), eluting with a dichloromethane/methanol/aqueous ammonia mixture (90/9/0,9 by volume) and then with a chloroform/methanol/aqueous ammonia mixture (77.5/19-5/3). The fractions containing the product are combined, concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40^C and dried in a desiccator (10 kPa). 0.34 g of 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3-fluorophenoxy)-ethyl]piperidine-4-carboxylic acid is obtained in the form of a white solid. 1H NMR Spectrum (300 MHz, {CD3)2SO-d6 with addition of a few drops of CF3COOD, 5 in ppm) : 1.34 (broad t, J = 12.5 Hz: 2H); from 1.50 to 1.70 (mt: 4H); 1.96 (broad d, J = 12.5 Hz: 2H); 2.08 (broad t, J = 11 Hz: 2H); 2.63 (t, J = 6 Hz: 2H); 2.70 (broad d, J = 11 Hz: 2H); 3.05 (broad t, J = 6.5 Hz: 2H); 3.97 (s: 3H); 4.06 (t, J = 6 Hz: 2H); from 6.70 to 6.90 (mt: 3H); from 7,25 to 7.40 (mt: 1H); 7.35 (d, J = 2.5 Hz: 1H); 7.40 (dd, J = 9 and 2.5 Hz: 1H); 7.97 (d, J = 9 Hz: 1H); 8,70 (broad s: 1H) . Ethyl 4- [3- (3-f luoro-6"niethoxy A mixture of 0.4 g of ethyl 4-[3-{3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate, 0.281 g of 1-(2-bromoethoxy)-3-fluorobenzene, 0.181 g of potassium iodide and 0.737 g of potassium carbonate in 15 cm3 of acetonitrile is stirred for 18 hours at a temperature in the region of 70°C. After cooling to about 20°C, the reaction mixture is concentrated to dryness under reduced pressure (5 kPa) at a temperature in the region of 40°C. The evaporation residue is purified by chromatography under atmospheric pressure, on a cartridge of silica gel (Bond Elut; particle size 70-200 fX; mass 12 g), eluting with a mixture of ethyl acetate/40-60°C petroleum ether (8/2 by volume). The fractions containing the product are combined and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. 0.43 g of ethyl 4-[3-(3-f luoro-6-Inethoxy-quinolin-4-yl)propyl] -1-[2-(3-fluorophenoxy)ethyl]-piperidine-4-carboxylate is obtained. 1H NMR Spectrum (500 MHz, (CD3)2SO-d6,δ in ppm) : 0.98 (t, J = 7 Hz: 3H); 1.35 (broad t, J = 12 Hz: 2H); from 1.45 to 1.65 (mt: 4H); 1.92 (broad d, J = 12 Hz: 2H); 2.00 (broad t, J = 11.5 Hz: 2H); from 2.30 to 2.70 (mt: 4H); 3.02 (mt: 2H); 3.91 (s: 3H); 3.94 (q, J = 7 Hz: 2H); 4.01 (mt: 2H); from 6.65 to 6.80 (mt: 3H); from 7.20 to 7.30 (mt: 1H); 7.28 (broad s: 1H); 7.36 (broad d, J = 9 Hz: 1H); 7.93 (d, J = 9 Hz: 1H); 8.65 (broad s: 1H). 1- (2-Broinoethoxy) -3-f luorobenzene A mixture of 8.6 g of 3-fluorophenol, 15.3 g of potassium carbonate and 40.5 cm3 of 1,2-dibromoethane in 2 00 cm3 of acetonitrile is stirred, under an inert atmosphere, at a temperature in the region of 70°C for 25 hours. After cooling to about 20^C, the suspension is filtered, the insoluble material is rinsed with 3 times 50 cm3 of acetonitrile and the filtrate is then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue obtained is taken up in 50 cm3 of diethyl ether and then filtered, and the filtration liquors are concentrated to dryness as under the previous conditions. The oil obtained by evaporation is purified by chromatography under a pressure of 50 kPa of argon on a colmnn of silica gel (particle size 20-45 (i; diameter 4.5 cm; height 22 cm), eluting with 40^60^C petroleum ether. Fractions 8 to 60 are combined and then concentrated to dryness under reduced pressure (2 kPa) in the region of 40°C. 7.67 g of 1-(2-bromoethoxy)-3-fluorobenzene are obtained. Infra-red spectrum (CCI4) : 1616; 1596; 1492; 1279; 1265; 1168; 1140; 1025; 853; 834 and 679 cm3 The ethyl 4-[3-(3^fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate was prepared in Example 11. Exainple 44 l-[2-(2,6-Difluorophenoxy)ethyl]-4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylic acid A mixture of 0.39 g of ethyl l-[2-{2,6-difluorophenoxy)ethyl]-4-[3-(3-fluoro-6^methoxyquinolin-4-yl) propyl] piperidine-4-carboxylate in 3 cm3 of dioxane, 3 cm3 of methanol and 2.2 cm3 of aqueous 5N sodium hydroxide solution is stirred at a temperature in the region of 70°C for 17 hours. After cooling to about 20^C, the reaction mixture is concentrated to dryness under a pressure gradually reduced from 30 kPa to 2.5 kPa and at a temperature in the region of 45°C. The residue is taken up in 5 cm3 of a dichloromethane/methanol/aqueous ammonia mixture (40/5/0.5 by volume) and is then purified by chromatography under atmospheric pressure, on a cartridge of silica gel (Bond Elut; particle size 70-200 ^; mass 10 g), eluting with a dichloromethane/methanol/aqueous ammonia mixture (90/9/0.9 by volume) and then with a chloroform/methanol/aqueous ammonia mixture (77.5/19.5/3). The fractions containing the product are combined, concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C and dried in a desiccator (10 kPa). 0.3 g of l-[2-(2,6- difluorophenoxy)ethyl]-4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylic acid is obtained in the form of a white solid. 1H NMR Spectrum (300 MHz, {CD3)2SO-d6,δ in ppm) : 1.33 (broad t, J = 12.5 Hz: 2H); from 1.50 to 1.65 (mt: 4H); 1.91 (broad d, J = 12.5 Hz: 2H); 2.05 (broad t, J = 11 Hz: 2H); 2.60 (t, J = 6 Hz: 2H); 2.63 (mt: 2H); 3.05 (mt: 2H); 3.97 (s: 3H); 4.16 (t, J = 6 Hz: 2H); from 7.05 to 7.20 (mt: 3H); 7.35 (d, J = 2.5 Hz: 1H); 7.40 (dd, J = 9 and 2.5 Hz: 1H); 7.97 (d, J = 9 Hz: 1H); 8.70 (broad s: 1H) . Ethyl 1-[2-(2,6-difluorophenoxy)ethyl]-4-[3-{3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate A mixture of 0.4 g of ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate, 0.304 g of 1-(2-bromoethoxy)-3-fluorobenzene, 0.181 g of potassium iodide and 0.74 g of potassium carbonate in 15 cm3 of acetonitrile is stirred for 18 hours at a temperature in the region of 7 0*°C. After cooling to about 20^C, the reaction mixture is concentrated to dryness under reduced pressure (5 kPa) at a temperature in the region of 40^C. The evaporation residue is purified by chromatography under atmospheric pressure, on a cartridge of silica gel (Bond Elut; particle size 70-200 ^i; mass 12 g), eluting with a mixture of ethyl acetate/40-60^C petroleum ether (8/2 by volxime) . The fractions containing the product are combined and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. 0.4 g of ethyl 1-[2-(2,6-difluoro-phenoxy)ethyl]-4-[3-(3-fluoro-6-methoxyquinolin-4-yl)-propyl]piperidine-4-carboxylate is obtained. 1H NMR Spectrum (500 MHz, (CD3)2SO-d6,δ in ppm) : 0.97 (t, J = 7 Hz: 3H); 1.26 (broad t, J = 125 Hz: 2H); from 1.40 to 1.60 (mt: 4H); 1.88 (broad d, J = 12 Hz: 2H); 1.98 (broad t, J = 11 Hz: 2H); from 2.30 to 2.65 (mt: 4H); 3.00 (mt: 2H); 3.92 (s: 3H); 3.94 (mt: 2H); 4.11 (mt: 2H); from 6.95 to 7.10 (mt: 3H); 7.30 (broad s: 1H) ; 7.37 (broad d, J := 9 Hz: 1H) ; 7.93 (d, J = 9 Hz: 1H); 8.66 (broad s: 1H). The ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4^carboxylate was prepared in Example 11. The 1-(2-bromoethoxy)-3-fluorobenzene was prepared according to the method described in Example 15. Exaictple 45 1-[2-(2,3-Difluorophenoxy)ethyl]-4-[3-(3-fluoro-6-methoxy A mixture of 0.42 g of ethyl l-[2-(2,3-difluorophenoxy)ethyl]-4-[3-(3-fluoro-6-inethoxyquinolin-4-yl)propyl]piperidine-4-carboxylate in 3 cm3 of dioxane, 3 cm3 of methanol and 2.4 cm3 of aqueous 5N sodium hydroxide solution is stirred at a temperature in the region of 70°C for 17 hours. After cooling to about 20°C, the reaction mixture is concentrated to dryness under a pressure gradually reduced from 30 kPa to 2.5 kPa and at a temperature in the region of 45*^C. The residue is taken up in 5 cm3 of a dichloromethane/methanol/aqueous ammonia mixture (40/5/0.5 by volume) and is then purified by chromatography under atmospheric pressure, on a cartridge of silica gel (Bond Elut; particle size 70-200 \i; mass 10 g), eluting with a dichloromethane/methanol/aqueous ammonia mixture (90/9/0.9 by volume) and then with a chloroform/methanol/aqueous ammonia mixture (77.5/19.5/3). The fractions containing the product are combined, concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C and dried in a desiccator (10 kPa). 0.32 g of l-[2-(2,3-difluorophenoxy)ethyl]-4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylic acid is obtained in the form of a white solid. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) : 1.34 (broad t, J = 12.5 Hz: 2H) ; from 1.50 to 1.70 (mt: 4H); 1.96 (broad d, J = 12.5 Hz: 2H); 2.09 (broad t, J = 11.5 Hz: 2H); 2.65 (t, J = 6 Hz: 2H); 2.71 (broad d, J = 11.5 Hz: 2H); 3.05 (mt: 2H); 3.97 (s: 3H); 4.16 (t, J = 6 Hz: 2H); from 6.90 to 7.20 (mt: 3H); 7.34 (d, J = 2.5 Hz: 1H); 7.40 (dd, J = 9 and 2.5 Hz: 1H); 7.97 (d, J = 9 Hz: 1H); 8.70 (broad s: 1H). Ethyl 1-[2-(2,3-difluorophenoxy)ethyl]-4-[3-(3-fluoro-6-methoxy A mixture of 0.4 g of ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate, 0.3 g of 1-(2-bromoethoxy)-2,3-difluorobenzene, 0.181 g of potassiiim iodide and 0.7 4 g of potassium carbonate in 15 cm3 of acetonitrile is stirred for 18 hours at a temperature in the region of 70*^C- After cooling to about 20°C, the reaction mixture is concentrated to dryness under reduced pressure (5 kPa) at a temperature in the region of 40°C. The evaporation residue is purified by chromatography under atmospheric pressure, on a cartridge of silica gel (Bond Elut; particle size 70-200 |X; mass 12 g), eluting with a mixture of ethyl acetate/40-60°C petroleum ether (8/2 by volume). The fractions containing the product are combined and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40^C. 0.43 g of ethyl l-[2-(2,3- difluorophenoxy)ethyl]-4-[3-(3-fluoro-6-inethoxyquinolin-4-yl)propyl]piperidine-4-carboxylate is obtained. 1H NMR Spectriim (500 MHz, (CD3)2SO-d6,δ in ppm) : 0,99 (xnt: 3H) ; 1.34 (mt: 2H) ; from 1.40 to 1.60 (mt: 4H) ; 1.93 (broad d, J = 12.5 Hz: 2H) ; from 1.95 to 2.10 (mt: 2H) ; from 2.45 to 2.70 (mt: 4H) ; 3.02 (mt: 2H) ; 3.93 (s: 3H); 3.95 (mt: 2H); 4.12 (mt: 2H); from 6.85 to 7.05 (mt: 2H); 7.09 (mt: 1H); 7.31 (broad s: 1H); 7.37 (broad d, J = 9 Hz: 1H); 7.94 (d, J = 9 Hz: 1H); 8.66 (broad s: 1H). The ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate was prepared in Example 11. The 1-(2-bromoethoxy)-2,3-difluorobenzene was prepared in Example 17. Exeunple 46 4- [3- (3-Fluoroquinolin A mixture of 1.29 g of ethyl 4-[3-(3-f luoro-quinolin-4-yl)propyl]-1-[2-(thien-2-yl)thioethyl]-piperidine-4-carboxylate in 65 cm3 of dioxane, 65 cm3 of methanol and 8 cm3 of aqueous 5N sodium hydroxide solution is stirred at a temperature in the region of 7 0°C for 20 hours. 8 cm3 of aqueous 5N sodium hydroxide solution are added to the reaction mixture, which is stirred in the region of 70°C for a further 6 hours. After cooling to about 20^C, the reaction mass is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 50°C, The residue is purified by chromatography under atmospheric pressure, on a column of silica gel (particle size 20-45 M-; diameter 6 cm; height 30 cm), eluting with a chloroform/methanol/-aqueous ammonia mixture (12/3/0.5 by volume) and collecting lOO-cm3 fractions. Fractions 8 to 24 are combined and concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The white solid is taken up in 60 cm3 of diisopropyl ether and stirred for 18 hours at a temperature in the region of 20°C. The suspension is filtered, washed with 3 times 15 cm3 of diisopropyl ether, spin-filtered and then dried under reduced pressure (10 kPa) at about 50*^C. 0.8 g of 4-[3-(3-fluoroquinolin-4-yl)propyl]-1-[2-(thien-2-yl)thioethyl]piperidine-4-carboxylic acid is obtained in the form of a white solid melting at 180°C. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) : 1.27 (mt: 2H); 1.56 (mt: 4H); from 1.85 to 2.05 (mt: 4H); 2.44 (broad t, J = 7 Hz: 2H); 2.57 (mt: 2H); 2.90 (broad t, J = 7 Hz: 2H); 3.06 (unresolved peak: 2H); 7.04 (dd, J = 5.5 and 3.5 Hz: 1H); 7.17 (dd, J = 3.5 and 1.5 Hz: 1H); 7.60 (dd, J = 5.5 and 1.5 Hz: 1H); 7.71 (broad t, J = 7.5 Hz: 1H); 7.77 (broad t, J = 7.5 Hz: 1H); 8.08 (broad d, J = 7.5 Hz: 1H); 8.15 (broad d, J = 7.5 Hz: 1H); 8.89 (d, J = 1.5 Hz: 1H). Ethyl 4-[3-(3-fluoroquinolin-4-yl)propyl]-l- [2-(thieii-2-yl)thioethyl]piperidine-4-carboxylate A mixture of 1.8 g of ethyl 1-(2-chloroethyl)-4-[3-{3-fluoroquinolin-4-yl)propyl]piperidine-4-carboxylate monohydrochloride, 0.48 cm3 of thiophene-2-thiol, 2.8 g of potassium carbonate and 0.7 5 g of potassium iodide in 200 cm3 of anhydrous acetonitrile is stirred under an inert atmosphere for 18 hours at a temperature in the region of 70*°C. After cooling to about 20^C, the suspension is filtered, washed with 3 times 30 cm3 of acetonitrile and the filtrate is then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 50°C. The evaporation residue is purified by chromatography under atmospheric pressure, on a column of silica gel (particle size 20-45 \i; diameter 6 cm; height 30 cm) , eluting with ethyl acetate and collecting 50-cm3 fractions. Fractions 25 to 52 are combined and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40^C. 1.3 g of ethyl 4-[3-(3-fluoroquinolin-4-yl)-propyl]-1-[2-(thiophen-2-ylthio)ethyl]piperidine-4-carboxylate are obtained in the form of a viscous orange-colored oil. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) : 0.99 (t, J = 7 Hz: 3H); 1.34 (very broad t, J = 13 Hz: 2H); 1.56 (mt: 4H); from 1.85 to 2.00 (mt: 4H); 2.45 (broad t, J = 7 Hz: 2H); 2.59 (broad d, J = 11.5 Hz: 2H); 2.90 (broad t, J = 7 Hz: 2H); 3.07 (broad t, J = 6.5 Hz: 2H); 3.95 (q, J = 7 Hz: 2H); 7,04 (dd, J = 5.5 and 3.5 Hz: 1H); 7.17 (dd, J = 3.5 and 1.5 Hz: 1H); 7.60 (dd, J = 5.5 and 1.5 Hz: 1H); 7.70 (broad t, J = 7.5 Hz: 1H); 7.77 (doubled triplet, J = 7.5 and 1,5 Hz: 1H); 8.08 (broad d, J = 7.5 Hz: 1H); 8.13 (broad d, J = 7.5 Hz: 1H); 8.89 (d, J = 1 Hz: 1H). Ethyl 1-(2-chloroethyl)-4-[3-(3-fluoroquinolin-4-yl)-propyl]piperidine-4-carboxylate hydrochloride 1.2 cm3 of thionyl chloride in 5 cwr' of dichloromethane are added to a solution of 1.55 g of ethyl 4-[3-(3-fluoroquinolin-4-yl)propyl]-1-(2-hydroxy-ethyl)piperidine-4-carboxylate in 35 cm3 of dichloromethane, with stirring at a temperature in the region of 20°C. After stirring for 42 hours at a temperature in the region of 20'^C, the reaction mixture is concentrated to dryness under reduced pressure (1.2 kPa) at about 50°C, The foam obtained is taken up in 3 times 100 cm3 of cyclohexane, concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°Cand oven-dried under reduced pressure (10 kPa) at a temperature in the region of 20°C. 1.8 g of ethyl l-(2-chloroethyl)-4-[3-(3-fluoroquinolin-4-yl)propyl]-piperidine-4-carboxylate monohydrochloride are obtained in the form of a cream-colored solid. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) : 1.03 (t, J = 7 Hz: 3H); from 1.45 to 2.10 (mt: 6H); 2.16 (broad d, J = 14 Hz: 2H); from 2.70 to 3.00 (mt: 2H); 3.12 (mt: 2H); from 3.40 to 3.55 (mt: 4H); from 3.95 to 4.10 (mt: 4H); 7.72 (broad t, J = 7.5 Hz: 1H); 7.79 (broad t, J = 7.5 Hz: 1H); 8.09 (broad d, J = 7.5 Hz: 1H); 8-18 (broad d, J = 7.5 Hz: 1H); 8.92 (broad s: 1H); from 10.10 to 10.35 (unresolved peak: 1H). Ethyl 4-[3-{3-fluoroquinolin-4-yl)propyl]-1-(2-hydroxy-ethyl)piperidine-4-carboxylate 1.14 cm3 of 2-iodoethanol and 1.9 g of potassium carbonate are added to a solution of 4.4 g of ethyl 4-[3-(3-fluoroquinolin-4-yl)propYl]piperidine-4-carboxylate in 100 cm3 of anhydrous acetonitrile, with vigorous stirring and under an inert atmosphere. The reaction mixture is stirred for 18 hours in the region of 20°C, filtered and washed with 3 times 30 cm3 of acetonitrile. The filtrate is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 50^C. The evaporation residue is purified by chromatography under atmospheric pressure, on a column of silica gel (particle size 20-45 \i; diameter 5 cm; height 32 cm), eluting with dichloromethane/methanol/aqueous ammonia (40/5/0.5 by volume) and collecting 100-cm3 fractions. Fractions 8 to 12 are combined and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40*°C. 3.5 g of ethyl 4-[3-(3-fluoroquinolin-4-yl)propyl]-1-(2-hydroxyethyl)-piperidine-4-carboxylate are obtained in the form of a viscous orange-colored oil. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) : 0.99 (t, J = 7 Hz: 3H); 1.36 (mt: 2H); 1.57 (mt: 4H); from 1.85 to 2.05 (mt: 4H); 2.29 (t, J = 6,5 Hz: 2H); 2.61 (d mt, J = 12 Hz: 2H); 3.08 (broad t, J = 6 Hz: 2H); 3.45 (mt: 2H); 3.96 (q, J = 7 Hz: 2H); 4.31 (t, J = 5.5 Hz: 1H); 7.70 (broad t, J = 7.5 Hz: 1H); 7.77 (doubled triplet, J = 7.5 and 1.5 Hz: 1H); 8.08 (dd, J = 7.5 and 1.5 Hz: 1H); 8.14 (dd, J = 7.5 and 1.5 Hz: 1H); 8.89 (d, J = 1 Hz: 1H). Ethyl 4-[3-(3-fluoroquinolin-4-yl)propyl]piperidine-4-carboxylate 50 cm3 of a solution of hydrogen chloride in dioxane at a concentration of 4M are added cautiously to a solution of 8.7 g of ethyl 4-[3-(3-fluoroquinolin-4-yl)propyl]-1-(tert-butyloxycarbonyl)piperidine-4-carboxylate in 150 cm3 of anhydrous dioxane, and the temperature is maintained below 30^C during the addition. After stirring for 18 hours in the region of 20°C, the suspension is diluted with 250 cm3 of diethyl ether, filtered and washed with 5 times 50 cm3 of diethyl ether, and the solid is dried in a desiccator under reduced pressure (2 kPa) and at a temperature in the region of 20°C. The solid is taken up in 50 cm3 of water and aqueous 5N sodium hydroxide solution is added so that the pH is at about 10, and the mixture is then extracted with 5 times 100 cm3 of diethyl ether. The organic phases are combined, dried over magnesium sulfate, taken up with plant charcoal (3S), filtered and concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 50°C. 4.7 g of ethyl 4-[3-(3-fluoroquinolin-4-yl)propyl]piperidine-4-carboxylate are obtained in the form of a viscous orange-colored oil. Mass spectrum: EI m/z = 344 M"" m/z = 288 Ci7Hi9FN02"' m/z = 184 CioHi8N02^- base peak m/z = 161 CioHsFN"" Ethyl 4-[3-(3-fluoroquinolin-4-yl)propyl]-1-(tert-butyloxycarbonyl)piperidine-4-carboxylate 17.7 g of ethyl 4-allyl-l-(tert-butyloxy-carbonyl)piperidine-4-carboxylate in 2 00 cm3 of tetrahydrofuran are cooled to a temperature in the region of -30°C and 135 cm3 of a 0. 5M solution of 9-borabicyclo-[3.3.l]nonane in tetrahydrofuran are added with stirring and under an inert atmosphere. After the addition, the temperature of the mixture is returned to about 20°C and the mixture is stirred for 2 hours. 14.8 g of 3-fluoro-4-iodoquinoline in 43 0 cm3 of tetrahydrofuran, 1.3 g of palladium diphenylphosphinoferrocene chloride and 29.8 g of tribasic potassium phosphate are added. The reaction mixture is then heated at a temperature in the region of 70°C for 20 hours. After cooling to a temperature in the region of 2 0°C, the reaction mass is filtered and washed with 3 times 100 cm3 of tetrahydrofuran. The filtrate is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The evaporation residue is taken up in 500 cm3 of diethyl ether, the insoluble material is washed with 3 times 100 cm3 of diethyl ether and the filtrate is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The oil obtained is purified by chromatography under atmospheric pressure, on a column of silica gel (particle size 20-45 |A; diameter 6 cm; height 45 cm), eluting with a dichloromethane/ethyl acetate mixture (90/10 by voliime) and collecting 120-cm3 fractions. Fractions 30 to 76 are combined and then concentrated to dryness under the same conditions as above. 13.7 g of ethyl 4-[3-(3-fluoroquinolin-4-yl)-propyl]-1-(tert-butyloxycarbonyl)piperidine-4-carboxylate are obtained in the form of a viscous orange-colored oil. Mass spectrum: EI m/z = 444 M""" m/z = 388 [M - tBu]""* m/z = 343 [M - BOC]^ m/z = 288 Ci7Hi9FN02^' m/z = 184 CioHi8N02^- m/z = 161 CioHsFN^ m/z = 57 C4H9"' 3-Fluoro-4-iodoquinoline 17.3 cin^ of diisopropylamine in 650 cm3 of tetrahydrofuran are cooled to a temperature in the region of -75°C and 76 cm3 of a 1. 6M solution of butyl lithium in hexane are added, with stirring and under an inert atmosphere, while maintaining the temperature at about -70^C. After stirring for 20 minutes at a temperature in the region of -75°C/ a solution of 11.9 g of 3-fluoro-quinoline in 200 cm3 of tetrahydrofuran is added. The solution obtained is stirred for a further 4 hours at -75°C, followed by addition of a solution of 32.2 g of double-sublimed iodine in 150 cm3 of tetrahydrofuran. After stirring for 2 hours at a temperature in the region of -40^C, the reaction mixture is hydrolyzed with 200 cm3 of a tetrahydrofuran/water mixture (90/10 by volume) and then with 2 00 cm3 of saturated sodium chloride solution. In the region of 20^C, the mixture is diluted with 300 cm3 of ethyl acetate and washed with twice 250 cm3 of saturated sodium chloride solution. The organic phase is dried over magnesium sulfate, filtered and concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 50^C. The residue obtained is purified by chromatography under atmospheric pressure, on a column of silica gel (particle size 20-45 ^; diameter 10 cm; height 30 cm), eluting with dichloromethane and collecting 100-cm3 fractions. Fractions 45 to 80 are combined and then concentrated to dryness under reduced pressure {2 kPa) at a temperature in the region of 40°C. 15.1 g of 3-fluoro-4-iodoquinoline are obtained in the form of a cream-colored solid melting at llO^C. Mass spectrum: EI m/z = 273 M""' base peak m/z = 146 [M - I]^ 3-Pluoroquinoline 23,5 g of 3-aminoquinoline and 12.1 g of sodium nitrite in 20 cm3 of distilled water are added cautiously to 100 cm3 of tetrafluoroboric acid cooled to about O^^C, with vigorous stirring, and the reaction mixture is thus stirred for 30 minutes. The suspension is filtered, spin-filtered, washed with 3 times 30 cm3 of ice-cold tetrafluoroboric acid, 50 cm3 of ice-cold ethanol and 4 times 30 cm3 of diethyl ether. The solid is dried in a desiccator (2 kPa) in the region of 20°Cand then taken up in 200 cm3 of toluene and heated at a temperature in the region of 90°C for 1 hour with stirring. After cooling to about 20°C, the phases of the reaction mass are separated by settling and the insoluble oil is washed with 3 times 100 cm3 of toluene and taken up in 110 cm3 of water, which is basified by slow addition of sodium hydrogen carbonate so that the pH is at about 8. The aqueous phase is extracted with 5 times 100 cm3 of diethyl ether and the organic phases are combined, washed with twice 50 cm3 of water, dried over magnesium sulfate and taken up with vegetable charcoal (3S), filtered and concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 45°C. The oil is taken up in 50 cm3 of a 40-60°C petroleum ether/ethyl acetate mixture (90/10 by volume) and the insoluble material is filtered off, rinsed with twice 25 cm3 of a 40-60°C petroleum ether/ethyl acetate mixture (90/10 by volume) and dried in a desiccator under reduced pressure (2 kPa) at a temperature in the region of 20°C. The filtrate is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40*^C. The residue obtained is purified by chromatography under atmospheric pressure, on a column of silica gel (particle size 20-45 jil; diameter 5 cm; height 45 cm), eluting with a 40-60°C petroleum ether/ethyl acetate mixture (90/10 by volume) and collecting 100-cm3 fractions. Fractions 20 to 31 are combined and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40*°C. 13 g of 3-fluoroquinoline are obtained in the form of a colorless liquid. Mass spectrum: EI m/z = 147 M""" base peak m/z = 127 [M - HF]^- m/z = 120 [M - HCN]" The ethyl 4-allyl-l-(tert-butoxycarbonyl)-piperidine-4-carboxylate was prepared in Example 1. Example 47 Ethyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-propyl]-1-[2-(pyridin-2-yloxy)ethyl]piperidine-4-carboxylate is prepared in the form of a viscous colorless oil. 1H NMR Spectrxim (3 00 MHz, (CD3)2SO-d6,δ in ppm) : 1.04 (t, J = 7 Hz: 3H); 1.39 (very broad t, J = 12 Hz: 2H); 1.51 (mt: 2H); 1.68 (mt: 2H); from 1.90 to 2.15 (mt: 4H); 2.60 (t, J = 6 Hz: 2H); 2.70 (broad d, J = 12 Hz: 2H); 3.16 (broad t, J = 7.5 Hz: 2H); 3.95 (s: 3H); 3.99 (q, J = 7 Hz: 2H); 4.31 (t, J = 6 Hz: 2H); 6.78 (d, J = 8 Hz: 1H); 6.96 (broad dd, J = 7.5 and 5 Hz: 1H); 7.37 (d, J = 2.5 Hz: 1H); 7.45 (dd, J = 9 and 2.5 Hz: 1H); 7.69 (ddd, J = 8-7.5 and 2 Hz: 1H); 7.96 (d, J = 9 Hz: 1H); 8.14 (broad dd, J = 5 and 2 Hz: 1H); 8.67 (s: 1H) . 4- [3- (3-Chloro-6-inethoxy A mixture of 0.12 g of ethyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl] -1-[2-(pyridin-2-yloxy)-ethyl]piperidine-4-carboxylate in 5 cm3 of dioxane, 5 cm3 of methanol and 1 cm3 of aqueous 5N sodium hydroxide solution is stirred at a temperature in the region of 70^C for 21 hours. After cooling to about 20°C, the reaction mass is concentrated to dryness under reduced pressure (5 kPa) at a temperature in the region of 60°C. The residue is taken up in 5 cm3 of a dichloromethane/methanol/aqueous ammonia mixture (40/5/0.5 by volume) and then purified by chromatography under atmospheric pressure, on a column of silica gel (particle size 70-200 µ diameter 1.5 cm; mass 20 g) , eluting with a dichloromethane/methanol/aqueous ammonia mixture (40/5/0.5 by volume). The fractions containing the product are combined and concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The foam is taken up in 2 cm3 of methanol, filtered, washed with 1 cm3 of methanol and 2 cm3 of diethyl ether and then oven-dried under reduced pressure (10 kPa) at about 50°C. 0.115 g of 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(pyridin-2-yloxy)ethyl]piperidine-4-carboxylic acid is obtained in the form of a white solid melting at about 70°C and becoming sticky. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) : from 1.20 to 1.80 (mt: 6H); 1.98 (very broad d, J = 13.5 Hz: 2H); 2.09 (very broad t, J = 11 Hz: 2H); 2.60 (t, J = 6 Hz: 2H); 2.67 (mt: 2H); 3.16 (mt: 2H); 3.98 (s: 3H); 4.32 (t, J = 6 Hz: 2H); 6.80 (d, J = 8 Hz: 1H); 6.96 (ddd, J = 7.5-5 and 1 Hz: 1H); 7.39 (broad s: 1H); 7.45 (dd, J = 9 and 2.5 Hz: 1H); 7.70 (ddd, J = 8-7.5 and 2 Hz: 1H); 7.97 (d, J = 9 Hz: 1H); 8.16 (broad dd, J = 5 and 2 Hz: 1H); 8.67 (s: 1H). Example 48 4- [3- (3-Chloro-6-methoxyquinolin-4-yl) -3- (R, S) -fluoropropyl]-1-[2-(2,5-difluorophenylthio)ethyl]-piperldlxie-4-carboxylic acid A mixture of 0.07 g of methyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-3-(R,S)-fluoropropyl]-1-[2-(2,5-difluorophenylthio)ethyl]piperidine-4-carboxylate in 3 cm3 of dioxane, 3 cm3 of methanol and 0.9 cm3 of aqueous 5N sodium hydroxide solution is maintained at a temperature in the region of 70°C for 4 hours. After cooling to about 20°C, the reaction mixture is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue is chromatographed under atmospheric pressure, on a column of silica gel (particle size 70-200 \x; mass 10 g) , eluting with a dichloromethane/methanol/aqueous ammonia mixture (40/5/0.5 by volume). Fractions 10 to 15 are combined and then concentrated to dryness under the same conditions as above. 0.04 g of 4-[3-(3-chloro-6-methoxy-quinolin-4-yl)-3-(R,S)-fluoropropyl]-1-[2-(2,5-difluorophenylthio)ethyl]piperidine-4-carboxylic acid is obtained in the form of a white solid. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) : from 1.20 to 2.60 (mt: 12H); 2.66 (mt: 2H); 3.03 (t, J = 7 Hz: 2H); 3.93 (s: 3H); 6.38 (mt, JHF = 48 HZ: 1H); 7.05 (mt: 1H); from 7.20 to 7.40 (mt: 2H); 7.52 (dd, J = 9 and 2.5 Hz: 1H); 7,56 (d, J = 2.5 Hz: 1H); 8.04 (d, J = 9 Hz: 1H); 8.75 (broad s: 1H); from 12.30 to 12.70 (broad unresolved peak: 1H). Methyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-3-(R,S)-fluoropropyl]-1-[2-(2,5-di£luorophenylthio)ethyl]-piperidine-4-carboxylate 0 -1 cm3 of diethylaminosulfur trif luoride is added to a solution of 0,25 g of methyl 4-[3-{3-chloro-6-methoxyquinolin-4-yl)-3-(R,S)-hydroxypropyl]-1-[2-(2,5-difluorophenylthio)ethyl]piperidine-4-carboxylate in 10 citi^ of dichloromethane, with stirring and under an inert atmosphere, at a temperature in the region of 5°C. After stirring for 7 hours at a temperature in the region of 20°C, saturated sodium hydrogen carbonate solution is added to the reaction mixture. The aqueous phase is extracted with dichloromethane. The organic phase is dried over magnesium sulfate, filtered and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue obtained is purified by chromatography under atmospheric pressure, on a column of silica gel (particle size 70-200 \i; mass: 15 g) , eluting with 60 cm3 of dichloromethane, then with 45 cm3 of a mixture of ethyl acetate/dichloromethane (1/9 by volume) , then with 30 cm3 of a mixture of ethyl acetate/dichloromethane (2/8 by volume) and then with 210 cm3 of a mixture of ethyl acetate/dichloromethane (3/7 by volume) and then with ethyl acetate. Fractions 24 to 2 6 are combined and then concentrated to dryness according to the same conditions as above. 0.08 g of methyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-3-(R,S)-fluoropropyl]-1-[2-(2,5-difluorophenylthio)ethyl]-piperidine-4-carboxylate is obtained in the form of a thick yellow oil. 1H NMR Spectrum (400 MHz, (CD3)2SO-d6,δ in ppm) : from 1.20 to 2.60 (mt: 12H); from 2,55 to 2.75 (mt: 2H); 3.11 (t, J = 7 Hz: 2H); 3.54 (s: 3H); 3.93 (s: 3H); 6.36 (mt, JHF = 48 HZ: 1H); 7.05 (mt: 1H); from 7.15 to 7.35 (mt: 2H); from 7.45 to 7.55 (mt: 2H); 8.03 (d, J = 9 Hz: 1H); 8.75 (s: 1H). Methyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-3-(R,S)-hydroxypropy1]-1-[2-(2,5-di£luorophenylthio)ethyl]-piperidine-4-carboxylate A mixture of 1.75 g of ethyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate dihydrochloride, 0.95 g of 2-(2-bromoethylthio)-1,4-difluorobenzene, 0.622 g of potassium iodide and 3.11 g of potassium carbonate in 30 cm3 of acetonitrile and 20 cm3 of dimethylformamide is heated with stirring for 18 hours at a temperature in the region of 85°C. After cooling to about 20°C, the reaction mixture is filtered through Celite and the filtrate is then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue obtained is taken up in water and diethyl ether. The organic phase is dried over magnesium sulfate, filtered and then concentrated to dryness as above. The residue obtained is purified by chromatography under atmospheric pressure, on a column of silica gel (particle size 70-200 µ diameter 4 cm) , eluting with a dichloromethane/methanol mixture (97.5/2.5 by volume). The fractions containing the product are combined and then concentrated to dryness according to the same conditions as above. 0.6 g of methyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-3-(R,S)-hydroxypropyl]-1-[2-(2,5-di fluorophenylthio)ethyl]piperidine-4-carboxylate is obtained. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δin ppm) : from 1.20 to 2.15 (mt: lOH); from 2.45 to 2.55 (mt: 2H); 2.64 (mt: 2H); 3.12 (t, J = 7 Hz: 2H); 3.47 (s: 3H); 3.87 (s: 3H); 5.41 (mt: 1H); 6.10 (unresolved peak: 1H); 7.04 (mt: 1H); from 7.15 to 7.35 (mt: 2H); 7.45 (dd, J = 9 and 2.5 Hz: 1H); 7.97 (d, J = 9 Hz: 1H); 8.13 (very broad d, J = 2.5 Hz: 1H); 8.66 (s: 1H). The 2-(2-bromoethylthio)-1,4-difluorobenzene may be obtained by applying the method described in Example 14. The methyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-3-(R,S)-hydroxypropyl]piperidine-4-carboxylate was prepared in Example 49. Example 49 4- [3- (3-Chloro-6-methoxyquinolin-4-yl) -3- (R, S) -fluoropropyl]-1-[2-(2,5-difluorophenoxy)ethyl]piperidine-4-carboxylic acid A mixture of 0.15 g of ethyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-3-(R,S)-fluoropropyl]-1-[2-(2,5-dif luorophenoxy) ethyl]piperidine-4-carboxylate in 3 cm3 of dioxane, 3 cm3 of methanol and 1 cm3 of aqueous 5N sodium hydroxide solution is maintained at a temperature in the region of 70°C for 4 hours. After cooling to about 20°C, the reaction mixture is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue is chromatographed under an atmospheric pressure of 60 kPa, on a Bond Elut of 60 cm3 of silica gel (particle size 70-200 µ mass 25 g) , eluting with 60 cm3 of a dichloromethane/methanol/aqueous ammonia mixture (40/5/0.5 by volume) and then with a dichloromethane/methanol/aqueous ammonia mixture (40/5/2 by volume). The fractions containing the expected product are combined and then concentrated to dryness according to the same conditions as above. 0.04 g of 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-3-(R,S)-fluoropropyl]-1- [2-(2, 5-difluorophenoxy)ethyl]piperidine-4-carboxylic acid is obtained in the form of a white solid. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) : from 1.20 to 2.40 (mt: lOH); 2.65 (t, J = 6 Hz: 2H); 2.72 (mt: 2H); 3.93 (s: 3H); 4.03 (t, J = 6 Hz: 2H); 6.37 (mt, JHF = 48 HZ: 1H); 6.75 (mt: 1H); 7.14 (mt: 1H); 7.25 (mt: 1H); 7.52 (dd, J = 9 and 2.5 Hz: 1H); 7.56 (d, J = 2.5 Hz: 1H); 8,03 (d, J = 9 Hz: 1H); 8.75 (d, J = 1 Hz: 1H). Methyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-3-(R,S)-fluoropropyl]-1-[2-(2,5-difluorophenoxy)ethyl]piperidine-4-carboxylate 0.2 cm3 of diethylaminosulfur trifluoride is added to a solution of 0.5 g of methyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-3-(R,S)-hydroxypropyl]-1-[2-(2, 5-difluorophenoxy)ethyl]piperidine-4-carboxylate in 20 cm3 of dichloromethane, with stirring and under an inert atmosphere, at a temperature in the region of 3°C. After stirring for 7 hours at a temperature in the region of 20*^C, saturated sodiiim hydrogencarbonate solution is added to the reaction mixture. The aqueous phase is extracted with dichloromethane. The organic phase is dried over magnesium sulfate, filtered and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue obtained is purified by chromatography under atmospheric pressure, on a column of silica gel (particle size 70-200 µ diameter 1.5 cm; mass: 15 g), eluting with a mixture of ethyl acetate/petroleum ether {40-60°C) (8/2 by volume). Fractions 9 to 11 are combined and then concentrated to dryness under the above conditions. 0.21 g of methyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-3-(R,S)-fluoropropyl] -1-[2-(2,5-difluorophenoxy)ethyl]piperidine-4- carboxylate is obtained in the form of a thick yellow oil. Mass spectrum: DCI m/z = 551 MH+ Presence of an impurity m' = 532. Methyl 4- [3- (3-chloro-6-methoxyquinolin-4-yl) -3- (R,S) -hydroxypropyl] -1- [2- (2, 5-dif luorophenoxy)ethyl] -piperidine-4-carboxylate A mixture of 1.55 g of methyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-3-hydroxypropyl]piperidine-4-carboxylate, 1.03 g of 1-(2-bromoethoxy)-2,5-difluorobenzene, 0.65 g of potassium iodide and 2.7 g of potassium carbonate in 30 cm3 of acetonitrile and 20 cm3 of dimethylformamide is heated with stirring at a temperature in the region of 85°C for 17 hours. After cooling to a temperature in the region of 20°C, the suspension is filtered through Celite and the filtrate is concentrated to dryness under reduced pressure (2 kPa) in the region of 40°C. The evaporation residue is taken up in dichloromethane and water. The organic phase is dried over magnesium sulfate, filtered and concentrated to dryness as under the above conditions. The residue is purified by chromatography under atmospheric pressure, on a column of silica gel (particle size 70-200 µ; diameter 4 cm), eluting with a mixture of dichloromethane/methanol (97/3 by volume). The fractions containing the product are combined and then concentrated to dryness under reduced pressure (2 kPa), at a temperature in the region of 40°C and under the same conditions as above. 0.5 g of methyl 4-[3-{3-chloro-6-methoxyquinolin-4-yl)-3-(R,S)-hydroxypropyl]-1-[2-(2,5-difluorophenoxy)ethyl]-piperidine-4-carboxylate is obtained. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δin ppm) : from 1.20 to 2.20 (mt: lOH); from 2.60 to 2.80 (mt: 2H); 2.64 (t, J = 6 Hz: 2H); 3.48 (s: 3H); 3.88 (s: 3H); 4.12 (t, J = 6 Hz: 2H); 5.40 (mt: 1H); 6.10 (broad s: 1H); 6.74 (mt: 1H); 7.13 (mt: 1H); 7.24 (mt: 1H); 7.44 (dd, J = 9 and 2.5 Hz: 1H); 7.96 (d, J = 9 Hz: 1H); 8.14 (d, J = 2.5 Hz: 1H); 8.66 (s: 1H). Methyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-3-{R,S)-hydroxypropyl]piperidine-4-carboxylate A mixture of 2.95 g of methyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-3-(R,S)hydroxypropyl]-(tert-butyloxycarbonyl)piperidine-carboxylate and 2.3 cm3 of sulfuric acid in 100 cm3 of methanol is heated at a temperature in the region of 80°C for 1 and a half hours. After cooling, the reaction mixture is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue is taken up in 10 cm3 of water, basified to pH = 11 with saturated sodium bicarbonate solution and then with saturated sodium carbonate solution and concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue obtained is purified by chromatography under atmospheric pressure, on a column of silica gel (particle size 20-45 µ; diameter 2 cm; volume 80 cm3) , eluting with a mixture of chloroform/methanol/aqueous ammonia (12/3/0.5 by volume). Fractions 8 to 20 are combined and then concentrated to dryness under the same conditions as above. 1.37 g of methyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-3-(R,S)hydroxypropyl]piperidine-4-carboxylate are obtained in the form of a cream-colored foam. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) : from 1.10 to 1.45 (mt: 3H); from 1.55 to 1.75 (mt: 1H); from 1.80 to 2.05 (mt: 4H); 2.40 (mt: 2H); 2.72 (mt: 2H); 3.50 (s: 3H); 3.90 (s: 3H); 5.42 (broad t, J = 6.5 Hz: 1H); 6.09 (mt: 1H); 7.45 (dd, J = 9 and 3 Hz: 1H); 7.97 (d, J = 9 Hz: 1H); 8.15 (d, J = 3 Hz: 1H); 8.67 (s: 1H). Methyl 4- [3- (3-chloro-6-methoxyquinolin-4-yl) -3- (R,S) -hydroxypropyl] - (tert-butyloxycarbonyl) piper idine carboxylate A solution of 5 g of ethyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-propyl]-1-(tert-butyloxycarbonyl)-piperidine-4-carboxylate in 400 cm3 of dimethyl sulfoxide and 120 cm3 of tert-butanol is stirred under an oxygen-saturated atmosphere at a temperature in the region of 20°C. After 5 minutes, a solution of 2.8 g of potassium tert-butoxide in 30 cm3 of tert-butanol is added to the reaction mixture. After sparging with oxygen for 2 hours, 300 cm3 of ice-cold water and 3.5 cm3 of acetic acid are added cautiously. The aqueous phase is extracted with twice 200 cm3 of dichloromethane. The organic phases are combined and washed with 4 times 1 cm3 of water. The organic phase is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue is taken up in 200 cm3 of diethyl ether, filtered, washed with 20 cm3 of diethyl ether and then dried in a dessicator under reduced pressure (0.1 kPa) at a temperature in the region of 40°C- 3 g of methyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-3-(R,S)hydroxypropyl]-{tert-butyloxycarbonyl)piperidine carboxylate are obtained in the form of a white solid melting at 222°C. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) : from 1.10 to 1.50 (mt: 3H); 1.39 (s: 9H); 1.70 (mt: 1H); from 1.80 to 2.10 (mt: 4H); 2.81 (mt: 2H); 3.69 (mt: 2H); 3.89 (s: 3H); 5.41 (dd, J = 9 and 5 Hz: 1H); from 5.80 to 6.30 (broad unresolved peak: 1H); 7.44 (dd, J = 9 and 3 Hz: 1H); 7.95 (d, J = 9 Hz: 1H); 8.16 (d, J = 3 Hz: 1H); 8.65 (s: 1H); from 12.00 to 12.90 (broad unresolved peak: 1H) . The 1-(2-bromoethoxy)-2,5-difluorobenzene was prepared in Example 16. The ethyl 4-[3-(3-chloro-6-methoxyquinolinyl)-propyl]-1-(tert-butoxycarbonyl)piperidine-4-carboxylate was prepared in Example 5 - Example 50 Ethyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)-propyl]-1-[2-(thia2ol-2-yloxy)ethyl]piperidine-4-carboxylate is prepared. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) : 1.05 (t, J = 7 Hz: 3H); 1.40 (very broad t, J = 12 Hz: 2H); 1.53 (mt: 2H); 1.69 (mt: 2H); from 1.90 to 2.15 (mt: 4H); 2.64 (t, J = 5.5 Hz: 2H); 2.70 (broad d, J = 11.5 Hz: 2H); 3.16 (broad t, J = 7.5 Hz: 2H); 3.96 (s: 3H); 4.01 (q, J = 7 Hz: 2H); 4.42 (t, J = 5.5 Hz: 2H); 7.04 (d, J = 3.5 Hz: 1H); 7.17 (d, J = 3.5 Hz: 1H); 7.37 (d, J = 2.5 Hz: 1H); 7.46 (dd, J = 9 and 2.5 Hz: 1H); 7.97 (d, J = 9 Hz: 1H); 8.67 (s: 1H). 4- [3- (3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [2-(thiazol-2-yloxy)ethyl]piperldine-4-carboxylic acid A mixture of 0.68 g of ethyl 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl] -1- [2-(thiazol-2-yloxy)-ethyl]piperidine-4-carboxylate in 7 cm3 of dioxane, 9 cm3 of methanol and 2 cm3 of aqueous 5N sodium hydroxide solution is maintained at a temperature in the region of 60°C for 20 hours. After cooling to about 20°C, the reaction mass is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue obtained is chromatographed under a pressure of 50 kPa of argon, on a column of silica gel (particle size 20-45 µ diameter 2.2 cm; mass 20 g) , eluting with a mixture of dichloromethane/methanol (70/30 by volume) . The fractions containing the expected product are combined and then concentrated to dryness under the above conditions. The residue obtained is taken up in 5 cm3 of ethyl acetate, stirred for 1 hour at room temperature and then filtered and rinsed with 3 times 3 cm3 of ethyl acetate and then 3 times 3 cm3 of pentane. 0.27 g of 4-[3-(3-chloro-6-methoxy-quinolin-4-yl)propyl]-1-[2-(thia2ol-2-yloxy)ethyl]-piperidine-4-carboxylic acid is obtained in the form of a white solid melting at 188°C. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) : 1.39 (broad t, J = 12 Hz: 2H); from 1.50 to 1.65 (mt: 2H); 1.71 (mt: 2H); 1.98 (broad d, J = 12 Hz: 2H); 2.12 (unresolved peak: 2H) ; from 2.60 to 2.85 (mt: 4H) ; 3.17 (broad t, J = 7.5 Hz: 2H) ; 3.96 (s: 3H) ; 4.45 (very broad t, J = 5.5 Hz: 2H); 7.05 (d, J = 3.5 Hz: 1H); 7.18 (d, J = 3.5 Hz: 1H); 7.37 (d, J = 2.5 Hz: 1H); 7.46 (dd, J = 9 and 2.5 Hz: 1H); 7.97 (d, J = 9 Hz: 1H); 8.68 (s: 1H); from 11.80 to 12.70 (broad imresolved pealc: 1H) . Example 51 4- [3- (3-f luoro-6-inethoxquinolin-4-yl)propyl] -1- [2- (4,5-dihydrothiazol-2-ylthio) ethyl]piperidine-4-carboxylic acid A mixture of 0.15 g of ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(4,5-dihydrothiazol-2-ylthio)ethyl]piperidine-4-carboxylate in 5 cm3 of dioxane. 5 cm3 of methanol and 1 cm3 of aqueous 5N sodium hydroxide solution is maintained at a temperature in the region of 75°Cfor 20 hours. After cooling to about 20°C, the reaction mixture is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue obtained is purified by chromatography under atmospheric pressure, on a column of silica gel (Bond Elut; particle size 70-200 µ mass 7 g), eluting with a mixture of dichloromethane/methanol/aqueous ammonia (40/5/0.5 by volume). The fractions containing the product are combined, concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C and then oven-dried under reduced pressure (10 kPa) at about 50°C- 0.1 g of 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-l-[2-(4,5-dihydrothiazol-2-ylthio)ethyl]-piperidine-4-carboxylic acid is obtained in the form of a white solid. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δin ppm) : 1.33 (very broad t, J = 11.5 Hz: 2H); 1.61 (mt: 4H); from 1.90 to 2.10 (mt: 4H); from 2.45 to 2.60 (mt: 2H); 2.63 (broad d, J = 11.5 Hz: 2H); 3.05 (mt: 2H); 3.19 (t, J = 6.5 Hz: 2H); 3.44 (t, J = 8 Hz: 2H); 3.97 (s: 3H); 4.15 (t, J = 8 Hz: 2H); 7.35 (broad s: 1H); 7.40 (broad d, J = 9 Hz: 1H); 7.97 (broad d, J = 9 Hz: 1H); 8.69 (broad s: 1H) . Ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4yl)propyl]-1-[2-(4,5-dihydrothiazol-2-ylthio)ethyl]piperidine-4-carboxylate A mixture of 0.7 g of ethyl 1-(2-chloroethyl)-4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate dihydrochloride, 0.18 g of 2-mercapto-thiazoline and 0.63 cm3 of triethylamine in 10 cm3 of dimethylformamide is stirred under an inert atmosphere for 23 hours at a temperature in the region of 80°C. After cooling to about 20°C, the reaction mixture is taken up in water, extracted with ethyl acetate and washed with saturated sodium chloride solution. The organic phase is dried over magnesium sulfate, filtered and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The evaporation residue is added to a solution of 0.18 g of 2-mercaptothiazoline and 0.06 g of 10% sodium hydride in 10 cm3 of dimethylformamide, and the mixture is then heated at a temperature in the region of 80°C for 15 hours. After cooling to about 20°C, the reaction mixture is taken up in water, extracted with ethyl acetate and washed with saturated sodium chloride solution. The organic phase is dried over magnesium sulfate, filtered and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue obtained is purified by chromatography under atmospheric pressure on a column of silica gel (particle size 70-200 µ; diameter 2 cm; mass 40 g), eluting with a mixture of dichloromethane/ethanol (95/5 by volume) and collecting 10-cm3 fractions. Fractions 11 to 24 are combined and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. 0.15 g of ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(4,5-di-hydrothiazol-2-ylthio)ethyl]piperidine-4-carboxylate is obtained in the form of a brown oil. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6, with addition of a few drops of CD3COOD d4, 5 in ppm) : 1.06 (t, J = 7 Hz: 3H) ; 1.41 (mt: 2H); from 1.50 to 1.70 (mt: 4H) ; 1.98 (broad d, J = 13.5 Hz: 2H); 2.14 (broad t, J = 11.5 Hz: 2H); 2.66 (t, J = 7 Hz: 2H); 2.80 (very broad d, J = 11.5 Hz: 2H); 3.04 (broad t, J = 6.5 Hz: 2H); 3.21 (t, J = 7 Hz: 2H); 3.42 (t, J = 8 Hz: 2H); 3.94 (s: 3H); 3.97 (q, J = 7 Hz: 2H); 4.12 (t, J = 8 Hz: 2H); 7.32 (d, J = 2.5 Hz: 1H); 7.38 (dd, J = 9 and 2.5 Hz: 1H); 7.96 (d, J = 9 Hz: 1H); 8.66 (d, J = 1.5 Hz: 1H). Ethyl 1-(2-chloroethyl)-4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate dihydrochloride 5.73 cm3 of thionyl chloride are added dropwise to a suspension of 0.6 g of ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-(2-hydroxyethyl)piperidine-4-carboxylate in 10 cm3 of dichloromethane with stirring in the region of 20°C, and the mixture is stirred for 24 hours at a temperature in the region of 20°C. The reaction mixture is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue is taken up in 3 times 30 cm3 of cyclohexane and evaporated to dryness as under the above conditions. 0.67 g of ethyl 1-(2-chloroethyl)-4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate dihydrochloride is obtained in the form of a beige-colored solid. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) : 1.05 {t, J = 7 Hz: 3H); from 1.45 to 2.00 (mt: 6H); 2.19 (broad d, J = 14 Hz: 2H); from 2.75 to 2.95 (mt: 2H); 3.09 (mt: 2H); from 3.40 to 3.60 (mt: 4H); from 3.95 to 4.15 (mt: 2H); 3.96 (s: 3H); 4.05 (q, J = 7 Hz: 2H); 7.37 (d, J = 2.5 Hz: 1H); 7.42 (dd, J = 9 and 2.5 Hz: 1H); 7.99 (d, J = 9 Hz: 1H); 8.73 (broad s: 1H); 10.00 (unresolved peak: 1H) . The ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-(2-hydroxyethyl)piperidine-4-carboxylate is prepared by analogy with the method described in Example 46. Example 52 4- [3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-l-[2-(3,4,5-trifluorophenoxy)ethyl]piperldine-4-carboxylic acid A mixture of 0.8 g of ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluoro- phenoxy)ethyl]piperidine-4-carboxylate in 50 cm3 of dioxane, 50 cm3 of methanol and 4.4 cm3 of aqueous 5N sodium hydroxide solution is stirred at a temperature in the region of 70°C for 18 hours. A further 4.4 cm3 of aqueous 5N sodium hydroxide solution are added to the reaction mixture, which is stirred for 6 hours in the region of 70°C. After cooling to about 20°C, the reaction mass is concentrated to dryness under reduced pressure (1.1 kPa) at a temperature in the region of 50°C. The residue is purified by chromatography under atmospheric pressure, on a column of silica gel (particle size 20-45 ^l; diameter 4 cm; height 20 cm) , eluting with a mixture of chloroform/methanol/aqueous ammonia (12/3/0.5 by volume) and collecting 60-cm3 fractions. Fractions 8 to 19 are combined, concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C and oven-dried under reduced pressure (10 kPa) at about 50°C- 0.59 g of 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)-propyl]-1-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4-carboxylic acid is obtained in the form of a white solid melting at about 120°C. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) : 1.32 (very broad t, J = 12 Hz: 2H); 1.59 (mt: 4H); 1.95 (broad d, J = 12 Hz: 2H); 2.07 (broad t, J = 11 Hz: 2H); 2.59 (t, J = 5.5 Hz: 2H); 2.68 (very broad d, J = 11 Hz: 2H); 3.04 (mt: 2H); 3.95 (s: 3H); 4.03 (t, J = 5.5 Hz: 2H); 6.97 (mt: 2H); 7.34 (d, J = 2.5 Hz: 1H); 7.39 (dd. J = 9 and 2.5 Hz: 1H); 7.96 (d, J = 9 Hz: 1H); 8.69 (broad s: 1H). Ethyl 4- [3- (3-f luoro-6-inethoxyquinolin-4-yl)propyl] -1- [2-(3,4,5-trif luorophenoxy)ethyl]piperidine-4-carboxylate A mixture of 0.62 g of ethyl 4-[3-(3-fluoro-6-inethoxyquinolin-4-yl)propyl]piperidine-4-carboxylate, 0.505 g of 5-(2-bromoethoxy)-1,2,3-trifluorobenzene, 0.34 g of potassium iodide and 1.14 g of potassium carbonate in 80 cm3 of acetonitrile is stirred under an inert atmosphere for 18 hours at a temperature in the region of 70°C. After cooling to about 20°C, the suspension is filtered and the insoluble material is washed with 3 times 30 cm3 of acetonitrile. The filtrate is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C- The evaporation residue is purified by chromatography under atmospheric pressure, on a column of silica gel (particle size 20-45 µ diameter 3 cm; height 21 cm) , eluting with ethyl acetate and collecting 40-cm3 fractions. Fractions 9 to 24 are combined and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40^C. 0.8 g of ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,4,5-trifluorophenoxy)ethyl]piperidine-4-carboxylate is obtained in the form of a pale yellow viscous oil. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) : 0.99 (t, J = 7 Hz: 3H); 1.37 (very broad t, J = 12 Hz: 2H) ; from 1.45 to 1.70 (mt: 4H) ; from 1.90 to 2.10 (mt: 4H); 2.59 (t, J = 5.5 Hz: 2H); 2.69 (broad d, J = 12 Hz: 2H); 3.04 (broad t, J = 7 Hz: 2H); 3.94 (s: 3H); 3.97 (q, J = 7 Hz: 2H); 4.03 (t, J = 5.5 Hz: 2H); 6.97 (mt: 2H); 7.33 (d, J = 2.5 Hz: 1H); 7.39 (dd, J = 9 and 2.5 Hz: 1H); 7.97 (d, J = 9 Hz: 1H); 8.69 (broad s: 1H). The ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate was prepared in Example 11. The 5-(2-bromoethoxy)-1,2,3-trifluorobenzene was prepared by applying the method described in Example 13. Example 53 4- [3- (3-f luoro-6-inethoxyquinolin-4-yl)propyl] -1- [2-(thlazol-2-ylthio)ethyl]piperidine-4-caxboxylic acid A mixture of 0.15 g of 4-[3-(3-fluoro-6-methoxy-quinolin-4-yl)propyl]-1-[2-(thiazol-2-ylthio)ethyl]-piperidine-4-carboxylate in 3 cm3 of dioxane, 3 cm3 of methanol and 1 cm3 of aqueous 5N sodium hydroxide solution is stirred at a temperature in the region of 70°C for 18 hours. After cooling to about 20°, the reaction mass is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 50°C. The residue is taken up in twice 20 cm3 of toluene and then concentrated to dryness as under the above conditions. The solid is purified by chromatography under atmospheric pressure, on a column of silica gel (Bond Elut; particle size 70-200 µ mass 7 g), eluting with a mixture of chloroform/methanol/-aqueous ammonia (84/14/2 by volume) and collecting 5-cm3 fractions. Fractions 8 to 19 are combined, concentrated to ciryness under reduced pressure (2 kPa) at a temperature in t he region of 40°C and then oven-dried under reduced Ijressure (to 10 kPa) at about 50°C. 0.114 g of 4-[3-(3-tluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(thiazol-2-yl-thio)ethyl]piperidine-4-carboxylic acid is obtained in the form of a white solid. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) : 1.31 (broad t, J = 12 Hz: 2H); 1.45 to 1.70 (mt: 4H); from 1.90 to 2.10 (mt: 4H); 2.58 (t, J = 7 Hz: 2H); 2.65 (broad d, J = 12 Hz: 2H); 3.04 (mt: 2H); from 3.25 to 3.45 (mt, ;:H) ; 3.95 (s: 3H) ; 7.34 (d, J = 2.5 Hz: 1H) ; 7.39 (dd, J = 9 and 2.5 Hz: 1H); 7.63 (d, J = 3.5 Hz: 1H); 7.71 (d, J = 3.5 Hz: 1H); 7.96 (d, J = 9 Hz: 1H); 8.68 (d, J = 1 Hz: 1H). Ethyl 4- [3- (3-f luoro-6-inethoxyquinolin-4-yl)propyl] -1- [2-(thiazol-2-ylthio)ethyl]piperidine-4-carboxylate A mixture of 0.65 g of ethyl 1-(2-chloroethyl)-1 -[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate dihydrochloride, 0.183 g of 2-mercapto-thiazole, 0.21 g of potassium iodide and 0.88 g of potassium carbonate in 50 cm3 of acetonitrile is stirred under an inert atmosphere for 18 hours at a temperature in the region of 70°C. After cooling to about 20°C, the suspension is filtered and the insoluble material is washed with acetonitrile. The filtrate is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. The evaporation residue is taken up in a mixture of ethyl acetate/40-60°C petroleum ether (8/2 by volume) and filtered, and the filtrate is purified by chromatography under atmospheric pressure on a column of silica gel (particle size 70-200 µ; diameter 1.5 cm; mass 100 g) , eluting with ethyl acetate/40-60°C petrole-um ether (8/2 by volume) and collecting 15-cm3 fractions. The fractions 41 to 100 are combined and then concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C. 0.15 g of ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-l-[2-{thiazol-2-ylthio)-ethyl]piperidine-4-carboxylate is obtained in the form of a thick yellow oil. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) : 1,00 (t, J = 7 Hz: 3H); 1.36 (broad t, J = 11.5 Hz: 2H); from 1,45 to 1.70 (mt: 4H>; from 1.85 to 2.10 (mt: 4H); 2.59 (t, J = 7 Hz: 2H); 2.68 (broad d, J = 12 Hz: 2H); 3.05 (very broad t, J = 7 Hz: 2H); 3.33 (mt; 2H); 3.95 (s: 3H); 3.98 (q, J = 7 Hz: 2H); 7.35 (d, J = 2,5 Hz: 1H); 7.40 (dd, J = 9 and 2,5 Hz: 1H); 7.64 (d, J = 3.5 Hz; 1H); 7.72 (d, J = 3.5 Hz: 1H); 7.97 (d, J = 9 Hz: 1H); 8.70 (d, J = 1 Hz: 1H). The ethyl 1-(2-chloroethyl)-4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate dihydrochloride was prepared in Example 51. Exang>le 54 4-[3-(3-f luoro-6-methoxyquinolin-4-yl)propyl]-1-(3-phenylallyl)piperidine-4-carboxylic acid A mixture of 0.13 g of ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-(3-phenylallyl)piperidine-4-carboxylate in 2 cm3 of dioxane, 2 cm3 of methanol and 1.32 cm3 of aqueous 5N sodium hydroxide solution is maintained at a temperature in the region of 70°C for 18 hours. After cooling to about 20°C, the reaction mixture is concentrated to dryness under reduced pressure (2 kPa) at a temperature in the region of 40°C The residue obtained is taken up in 10 cm3 of water, acidified with acetic acid and extracted with ethyl acetate, allowed to separate by settling and then filtered and rinsed with twice 10 cm3 of ethanol. 0.12 g of 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-(3-phenylallyl)piperidine-4-carboxylic acid is obtained in the form of a white solid melting at 240°C. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) : 1.35 (broad t, J = 11.5 Hz: 2H); from 1.50 to 1.75 (mt: 4H) ; from 1.85 to 2.10 (mt: 4H) ; 2.63 (Droaa a, J = 11.3 Hz: 2H) ; from 2.95 to 3.15 (mt: 4H) ; 3.96 (s, 3H) ; 6.26 (dt, J = 16 and 7 Hz: 1H); 6.50 (d, J = 16 Hz: 1H); from 7.10 to 7.50 (mt: 7H); 8.06 (d, J = 9 Hz: 1H); 8.69 (broad s: 1H). Ethyl 4- [3- (3-f luoro-6-methoxyquinolin-4-yl)propyl] -1- (3-phenylallyl)piperidine-4-carboxylate 77 mg of borane-pyridine complex are added to a mixture of 0.31 g of ethyl 4-[3-(3-fluoro-6-methoxy-quinolin-4-yl)propyl]piperidine-4-carboxylate and 0.1 cm3 of trans-cinnamaldehyde in 10 cm3 of ethanol. The reaction mixture is maintained at a temperature in the region of 77 0.13 g of ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)-propyl]-1-(3-phenylallyl)piperidine-4-carboxylate is obtained in the form of a viscous oil. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6,δ in ppm) : 1.01 (t, J = 7 Hz: 3H); 1.40 (broad t, J = 11.5 Hz: 2H); from 1.45 to 1.75 (mt: 4H); from 1.90 to 2.05 (mt: 4H); 2.65 (very broad d, J = 12 Hz: 2H); 3.02 (d, J = 7 Hz: 2H); 3.05 (mt: 2H); 3.96 (s: 3H); 3.97 (q, J = 7 Hz: 2H); 6.25 (dt, J = 16 and 7 Hz: 1H); 6.51 (d, J = 16 Hz: 1H); from 7.15 to 7.50 (mt: 7H); 7.96 (d, J = 9 Hz: 1H); 8.70 (d, J = 1 Hz: 1H). The ethyl 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylate was prepared in Example 11. Example 55 4- [3- (3-Chloro-6-methoxyquinolin-4-yl)propyl] -1- (3-phenylpropyl)piperidine-4-hydroxaitiic acid A solution of 0.1 g of 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-(3-phenylpropyl)-piperidine-4-tert-butoxycarboxamide in 2 cm3 of trifluoroacetic acid is left for 60 days at a temperature in the region of 20°C- The solution is evaporated off under reduced pressure (2 kPa) at a temperature in the region of 40°C and then purified by chromatography under atmospheric pressure on Bond Elut silica (particle size 70-200 µ volume 25 cm3) , eluting with a mixture of dichloromethane/methanol/aqueous ammonia (40/5/0.3 by-volume) . The fractions containing the product are combined and then evaporated under the conditions described above. 0.036 g of 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-{3-phenylpropyl)-piperidine-4-hydroxamic acid is obtained in the form of a colorless oil. 1H NMR Spectrum (300 MHz, (CD3)2SO-d6, 5 in ppm) : 1.33 (mt: 2H); 1.51 (mt: 2H); from 1.60 to 1.80 (mt: 4H); from 1.90 to 2.10 (mt: 4H); 2.18 (t, J = 7 Hz: 2H); from 2.45 to 2.65 (mt: 4H); 3.12 (broad t, J = 7.5 Hz: 2H); 3.96 (s: 3H); from 7.15 to 7.25 (mt: 3H); 7.28 (t mt, J = 7.5 Hz: 2H); 7.36 (d, J = 2.5 Hz: 1H); 7.45 (dd, J = 9 and 2.5 Hz: 1H); 7.96 (d, J = 9 Hz: 1H); 8.56 (unresolved peak: 1H); 8.67 (s: 1H); 10.37 (unresolved peak: 1H). 4-[3-(3-Chloro-6-methoxyquinolin-4-yl)propyl]-l-(3-phenylpropyl)piperidine-4-tert-butoxyamide A mixture of 0.5 g of 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-(3-phenylpropyl)-piperidine-4-carboxylic acid, 0.175 g of 1-hydroxy-benzotriazole hydrate, 0.498 g of 1-[3-(dimethylamino)-propyl]-3-ethylcarbodiimide hydrochloride, 0.58 cm^ of triethylamine and 0.4 g of O-tert-butylhydroxylamine is stirred for 48 hours at a temperature in the region of 20°C. The reaction medium is diluted with 50 cm3 of water, stirred and the phases are then separated by settling. The aqueous phase is extracted with twice 2 5 cm3 of dichloromethane and the organic extracts are combined, dried over magnesium sulfate, filtered and then evaporated under reduced pressure (2 kPa) at a temperature in the region of 40°C. The residue obtained is purified by chromatography under atmospheric pressure, on a column of silica gel (particle size 20-45 °; diameter 2.5 cm; mass 18 g), eluting with a mixture of dichloromethane/methanol/agueous ammonia (40/5/0.2 by volume). The fractions containing the product are combined and then evaporated under the conditions described above. 0.27 g of 4-[3-(3-chloro-6-methoxy-quinolin-4-yl)propyl]-1-(3-phenylpropyl)piperidine-4-tert-butoxyamide is obtained. ^H NMR Spectrum (300 MHz, (CD3)2SO-d6, δ in ppm) : 1.09 (s: 9H); 1.35 (mt: 2H); 1.54 (mt: 2H); 1.67 (mt: 4H); 1.95 (broad t, J = 11 Hz: 2H); 2.08 (broad d, J = 13.5 Hz: 2H); 2-19 (t, J = 7 Hz: 2H); from 2.50 to 2.65 (mt: 4H); 3.14 (broad t, J = 7.5 Hz: 2H); 3.98 (s: 3H); from 7.10 to 7.25 (mt: 3H); 7.27 (broad t, J = 7.5 Hz: 2H); 7.36 (d, J =2.5 Hz: 1H); 7.45 (dd, J = 9 and 2.5 Hz: 1H); 7,96 (d, J = 9 Hz: 1H); 8.68 (s: 1H); 10,06 (broad s: 1H). 4-[3-(-3-Chloro-6-methoxyquinoline-4-yl)propyl]-1-(3-phenylpropyl)piperidine-4-carboxylic acid dihydrochloride was prepared in Example 4. Benzyl 4-[3-{3-chloro-6-methoxyquinolin-4-yl)- propyl]-1-(3-phenylpropyl)piperidine-4-carboxylate was prepared in Example 4. Exainple 56 4-[3-(3-Pluoro-6-methoxyquinolin-4-yl)propyl]-1-[3-(2,5-difluorophenyl)prop-2-enyl]piperidine-4-carboxylic acid hydrochloride Working in a manner analogous to that of Example 54, 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)-propyl] -1- [3- (2 , 5-dif luorophenyl)prop-2-enyl]piperidine-4-carboxylic acid hydrochloride is prepared. 1H NMR Spectrum (400 MHz, (CD3)2SO-d6 with addition of a few drops of CD3COOD-d4 at a temperature of 383 K, 5 in ppm): 1.73 (mt: 6H); 2.22 (broad d, J = 14 Hz: 2H) ; 3.01 (unresolved peak: 2H) ; 3.11 (broad t, J = 7 Hz: 2H); 3.42 (very broad d, J = 12 Hz: 2H); 3.94 (d, J = 7 Hz: 2H); 3.98 (s : 3H) ; 6.48 (dt, J = 16.5 and 7 Hz: 1H); 6.93 (d, J = 16.5 Hz: 1H); from 7.10 to 7,30 (mt: 2H); 7.35 (broad s: 1H); 7.40 (dd, J = 9 and 2.5 Hz: 1H); 7.44 (mt: 1H); 7.98 (d, J = 9 Hz: 1H); 8.64 (broad s: 1H). Example 57 4-[3-(3-Fluoro-6-methoxyqainolin-4"yl)propyl]-l-[2-(2,5-difluorophenoxy)ethyl]piperidine-4-hydroxamic acid Working in a manner analogous to that of Example 55, 4-[3-(3-fluoro-6-methoxyquinolin-4-yl)-propyl]-1-[2-(2,5-difluorophenoxy)ethyl]piperidine-4-hydroxamic acid is prepared. ^H NMR Spectrum (300 MHz, (CD3)2SO-d6, 5 in ppm) : 1,31 (very broad t, J = 12.5 Hz: 2H) ; from 1.45 to 1.70 (mt: 4H); 2.02 (broad d, J = 12.5 Hz: 2H); 2.10 (broad t, J = 11 Hz: 2H); from 2.55 to 2.75 (mt: 4H); 3.00 (mt: 2H) ; 3.97 (s: 3H); 4.12 (t, J = 5.5 Hz: 2H); 6.75 (mt: 1H); 7.14 (mt: 1H) 7.24 (mt: 1H); 7.33 (d, J = 3 Hz: 1H); 7.40 (dd, J = 9 and 3 Hz: 1H); 7.96 (d, J = 9 Hz: 1H); 8.63 (unresolved peak: 1H); 8.70 (d, J = 0.5 Hz: 1H); 10.40 (unresolved peak: 1H). Ex€UKple 58 l-Cinnanyl-4- [3- (3-f luoro-6-methoxyquinolin-4-yl)propyl] -piperldlne-4-hydroxanic acid Working in a manner analogous to that of Example 55, l-cinnamyl-4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-piperidine-4-hydroxamic acid is prepared. 1H NMR Spectrum (400 MHz, (CD3)2SO-d6 with addition of a few drops of CD3COOD-d4 at a temperature of 373 K, 5 in ppm): from 1.50 to 1.75 (mt: 6H); 2.23 (broad d, J = 14 Hz: 2H); 2.81 (broad t, J = 11.5 Hz: 2H); 3.04 (mt: 2H); 3.22 (broad d, J = 11.5 Hz: 2H); 3.69 (d, J = 7 Hz: 2H); 3.97 (s: 3H); 6.24 (dt, J = 16 and 7 Hz: 1H); 6.78 (d, J = 16 Hz: 1H); from 7.20 to 7.50 (mt: 7H); 7.96 (d, J = 9 Hz: 1H); 8.62 (broad s: 1H). Exampple 59 Sodium 4- [3- (3-chloro-6-trifluoromethylquinolin-4-yDpropyl] -1~ [2- (2, 5-di£luorophenoxy)ethyl]piperidine-4-carboxylate Working in a manner analogous to that of Example 1, sodiiim 4-[3-(3-chloro-6-trifluoromethylquinolin-4-yl)propyl]-1-[2-(2,5-difluorophenoxy)ethyl]piperidine-4-carboxylate was prepared. 1H NMR Spectriom (300 MHz, (CD3)2SO-d6, 5 in ppm) : 1.09 (very broad t, J = 11.5 Hz: 2H); from 1.40 to 1.70 (mt: 4H); 1.98 (broad d, J = 11.5 Hz: 2H); 2.14 (t, J = 10.5 Hz: 2H); from 2.50 to 2.70 (mt: 4H); 3.22 (broad t, J = 7 Hz: 2H); 4.10 (t, J = 5.5 Hz: 2H); 6.74 (mt: 1H); 7.12 (mt: 1H); 7.23 (mt: 1H); 8.06 (broad d, J = 9 Hz: 1H); 8.26 (d, J = 9 Hz: 1H); 8.26 (d, J = 9 Hz: 1H); 8.54 (broads: 1H); 9.00 (s: 1H). The present invention also relates to pharmaceutical compositions containing at least one heterocyclylalkylpiperidine derivative according to the invention, where appropriate in the form of a salt, in pure form or in the form of a combination with one or more compatible and pharmaceutically acceptable diluents and/or adjuvants. The compositions according to the invention maybe used orally, parenterally, topically, rectally or as aerosols. Solid compositions for oral administration which may be used include tablets, pills, gel capsules, powders or granules. In these compositions, the active product according to the invention is mixed with one or more inert diluents or adjuvants, such as sucrose, lactose or starch. These compositions may comprise substances other than diluents, for example a lubricant such as magnesium stearate or a coating intended for controlled release. Liquid compositions for oral administration which may be used include pharmaceutically acceptable solutions, suspensions, emulsions, syrups and elixirs containing inert diluents such as water or liquid paraffin. These compositions may also comprise substances other than diluents, for example wetting, sweetening or flavoring products. The compositions for parenteral administration may be sterile solutions or emulsions. Solvents or vehicles which may be used include water, propylene glycol, a polyethylene glycol, plant oils, in particular olive oil, and injectable organic esters, for example ethyl oleate. These compositions may also contain adjuvants, in particular wetting agents, isotonic agents, emulsifiers, dispersants and stabilizers. The sterilization may be carried out in several ways, for example using a bacteriological filter, by irradiation or by heating. The compositions may also be prepared in the form of sterile solid compositions which may be dissolved at the time of use in sterile water or any other injectable sterile medium. The compositions for topical administration may be, for example, creams, ointments, lotions or aerosols. The compositions for rectal administration are suppositories or rectal capsules which contain, besides the active principle, excipients such as cocoa butter, semi-synthetic glycerides or polyethylene glycols. The compositions may also be aerosols. For use in the form of liquid aerosols, the compositions may be stable sterile solutions or solid compositions dissolved at the time of use in apyrogenic sterile water, in saline or any other pharmaceutically acceptable vehicle. For use in the form of dry aerosols intended to be inhaled directly, the active principle is finely divided and combined with a water-soluble solid diluent or vehicle with a particle size of from 30 to 80 µm, for example dextran, mannitol or lactose. In human therapy, the novel heterocyclylalkylpiperidine derivatives according to the invention are particularly useful in the treatment of infections of bacterial origin. The doses depend on the desired effect and on the duration of the treatment. The doctor will determine the dosage he considers most appropriate as a function of the treatment, depending on the age, weight, degree of infection and other factors specific to the individual to be treated. Generally, the doses are between 750 mg and 3 g of active product taken 2 or 3 times a day orally or between 400 mg and 1.2 g intravenously for an adult. CLAIMS 1. A heterocyclylalkylpiperidine derivative of general formula: for which: X1, X2, X3, X4 and X5 represent, respectively, >C-R'i to >C-R'5, or alternatively not more than one of them represents a nitrogen atom, R1, R'l, R'2, R'3, R'4 and R'5 are identical or different and represent a hydrogen or halogen atom or an alkyl, cycloalkyl, phenyl, phenylthio, mono- or bicyclic aromatic heterocyclyl or heterocyclylthio, hydroxyl, alkyloxy, trifluoromethoxy, alkylthio, trifluoro-methylthio, cycloalkyloxy, cycloalkylthio, cyano, carboxyl, alkyloxycarbonyl, cycloalkyloxycarbonyl, -NRaRb or -CONRaRb radical (for which Ra and Rb can represent hydrogen, alkyl, cycloalkyl, phenyl, mono- or bicyclic aromatic heterocyclyl or Ra and Rb form, together with the nitrogen atom to which they are attached, a 5- or 6-membered heterocycle which can optionally contain another heteroatom chosen from 0, S and N and, where appropriate, bearing an alkyl, phenyl or mono- or bicyclic aromatic heterocyclyl substituent on the nitrogen atom or, where appropriate, the sulfur atom of which is oxidized in the form of sulfinyl or sulfonyl), or represent a methylene radical substituted with fluoro, hydroxyl, alkyloxy, alkylthio, cycloalkyloxy, cycloalkylthio, phenyl, mono-or bicyclic aromatic heterocyclyl, carboxyl, alkyloxycarbonyl, cycloalkyloxycarbonyl, -NRaRb or -CONRaRb for which Ra and Rb are defined as above, or represent phenoxy, heterocyclyloxy, benzyloxy, heterocyclylmethyloxy, or alternatively Ri can also represent difluoromethoxy, or a radical of structure -CmF2m+1, -SCmF2m+1 or -0CmF2in+i for which m is an integer from 1 to 6, or alternatively R'5 can also represent tri fluoroacetyl, R2 represents carboxyl, alkyloxycarbonyl, cycloalkyloxycarbonyl, cyano, -CONRaRb (for which Ra and Rb represent, respectively, hydrogen, alkyl, cycloalkyl, phenyl, mono- or bicyclic aromatic heterocyclyl, or Ra or Rb represents hydroxyl, alkyloxy, cycloalkyloxy, or Ra and Rb form, together with the nitrogen atom to which they are attached, a 5- or 6-membered heterocycle which can optionally contain another heteroatom chosen from 0, S and N and, where appropriate, bearing an alkyl, phenyl or mono- or bicyclic aromatic heterocyclyl substituent on the nitrogen atom or, where appropriate, the sulfur atom of which is oxidized in the form of sulfinyl or sulfonyl), or R2 represents hydroxymethyl, alkyl containing 1 or 2 carbon atoms substituted with carboxyl, alkyloxycarbonyl, cycloalkyloxycarbonyl, cyano or -CONRaRb for which Ra and Rb are defined as above, or R2 represents a radical of structure -CF2-RC, -C(CH3)2-Rc, -CO-Rc, -CHOH-Rc, -C(cycloalkyl)-Rc, or -CH=CH-Rc for which Rc is carboxyl, alkyloxycarbonyl, cycloalkyloxy-carbonyl, or -CONRaRb for which Ra and Rb are defined as above, R3 represents a phenyl, mono- or bicyclic aromatic heterocyclyl or alk-R°3 radical for which alk is an alkyl radical and R°3 represents hydrogen, halogen, hydroxyl, alkyloxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, dialkylamino, cycloalkyl, cycloalkyloxy, cycloalkylthio, eyeloalkylsulfinyl, eyeloalkylsulfonyl, cycloalkylamino, N-eyeloalkyl-N-alkylamino, -N-(cycloalkyl)2, acyl, cycloalkylcarbonyl, phenyl, phenoxy, phenylthio, phenylsulfinyl, phenylsulfonyl, phenylamino, N-alkyl-N-phenylamino, N-cycloalkyl-N-phenylamino, -N-(phenyl)2/ phenylalkyloxy, phenylalkylthio, phenylalkylsulfinyl, phenylalkylsulfonyl, phenylalkylamino, N-alkyl-N-phenylaminoalkyl, N-cycloalkyl-N-phenylalkylamino, benzoyl, mono- or bicyclic aromatic heterocyclyl, heterocyclyloxy, heterocyclylthio, heterocyclylsulfinyl, heterocyclylsulfonyl, heterocyclylamino, N-alkyl-N-heterocyclylamino, N-cycloalkyl-N-heterocyclylamino, heterocyclylcarbonyl, heterocyclylalkyloxy, heterocyclylalkylthio, heterocyclylalkylsulfinyl, heterocyclylalkylsulfonyl, heterocyclylalkylamino, N-alkyl-N-heterocyclylaminoalkyl, N-cycloalkyl-N-heterocyclylaminoalkyl, (the heterocyclyl portions mentioned above being mono- or bicyclic aromatic), carboxyl, alkyloxycarbonyl, -NRaRb or -CO-NRaRb for which Ra and Rb are defined as above in the definition of R2, or alternatively R°3 represents -CR'b=CR'c-R'a for which R'a represents phenyl, phenylalkyl, heterocyclyl or heterocyclylalkyl in which the heterocyclyl portion is mono- or bicyclic aromatic, phenoxyalkyl, phenylthioalkyl, phenylsulfinylalkyl, phenylsulfonylalkyl, phenylaminoalkyl, N-alkyl-N-phenylaminoalkyl, heterocyclyloxyalkyl, heterocyclylthioalkyl, heterocyclylsulfinylalkyl, heterocyclylsulfonylalkyl, heterocyclylaminoalkyl, N-alkyl-N-heterocyclylaminoalkyl, heterocyclylthio, heterocyclylsulfinyl, heterocyclylsulfonyl, (the heterocyclyl portions mentioned above being mono- or bicyclic aromatic), phenylthio, phenylsulfinyl, phenylsulfonyl, and for which R'b and R'c represent hydrogen, alkyl or cycloalkyl, or alternatively R°3 represents a radical -C=C-Rd for which Rd is alkyl, phenyl, phenylalkyl, phenoxyalkyl, phenylthioalkyl, N-alkyl-N-phenylaminoalkyl, mono- or bicyclic aromatic heterocyclyl, heterocyclylalkyl, heterocyclyloxyalkyl, heterocyclylthioalkyl, heterocyclylaminoalkyl, N-alkyl-N-heterocyclylaminoalkyl, (the heterocyclyl portions mentioned above being mono- or bicyclic aromatic) , or alternatively R°3 represents a -CF2-phenyl or mono- or bicyclic aromatic -CF2-heterocyclyl radical, Y represents a radical >CH-Re for which Re is hydrogen, fluoro, hydroxyl, alkyloxy, cycloalkyloxy, carboxyl, alkyloxycarbonyl, cycloalkyloxycarbonyl, -NRaRb or -CO-NRaRb for which Ra and Rb are defined as above for R2 or one represents a hydrogen atom and the other represents an alkyloxycarbonyl, acyl, cycloalkylcarbonyl, benzoyl or heterocyclylcarbonyl radical in which the heterocyclyl portion is mono- or bicyclic aromatic, or alternatively Y represents a difluoromethylene, carbonyl, hydroxyiminomethylene, alkyloxyiminomethylene or cycloalkyloxyiminomethylene radical or a 1,1-cycloalkylene radical containing 3 to 6 carbon atoms, and n is an integer from 0 to 4, it being understood that the phenyl, benzyl, benzoyl or heterocyclyl radicals or portions mentioned above may optionally be substituted on the ring with 1 to 4 substituents chosen from halogen, hydroxyl, alkyl, alkyloxy, alkyloxyalkyl, haloalkyl, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, carboxyl, alkyloxycarbonyl, cyano, alkylamino, -NRaRb for which Ra and Rb are defined as above, phenyl, hydroxyalkyl, alkylthioalkyl, alkylsulfinylalkyl and alkylsulfonylalkyl, it being understood that the alkyl or acyl radicals and portions contain (except where especially mentioned) 1 to 10 carbon atoms in a straight or branched chain and that the cycloalkyl radicals contain 3 to 5 carbon atoms, in their enantiomeric or diastereoisomeric forms or mixtures of these forms, and/or, where appropriate, in their syn or anti form or a mixture thereof, as well as the salts thereof, 2 . A heterocyclylalkylpiperidine derivative as claimed in claim 1, characterized in that X1, X2, X3, X4 and X5 represent, respectively, >C-R'1 to >C-R'5, or alternatively not more than one of them represents a nitrogen atom, R1 R'l, R'2, R'3, R'4 and R'5 are identical or different and represent a hydrogen or halogen atom or an alkyl or alkyloxy radical, or represent a methylene radical substituted with alkyloxy, R2 represents carboxyl, alkyloxycarbonyl or -CONRaRb (for which Ra represents a hydrogen atom and Rb represents a hydrogen atom or a hydroxyl radical) or R2 represents hydroxymethyl, alkyl containing 1 or 2 carbon atoms substituted with carboxyl, or alkyloxycarbonyl, R3 represents a radical alk-R°3 for which alk is an alkyl radical and R°3 represents hydrogen, cycloalkyl, cycloalkylthio, phenyl, phenoxy, phenylthio, phenylamino, heterocyclyloxy or heterocyclylthio or alternatively R°3 represents -CR'b=CR'c-R'a for which R'a represents phenyl, and for which R'b and R'c represent hydrogen, Y represents a radical >CH-Re for which Re is hydrogen, fluoro or hydroxy1, n is an integer from 2 to 3, it being understood that the phenyl or heterocyclyl radicals or portions mentioned above may optionally be substituted on the ring with 1 to 4 halogens, and it being understood that the alkyl or acyl radicals and portions contain (except where especially mentioned) 1 to 10 carbon atoms in a straight or branched chain and that the cycloalkyl radicals contain 3 to 6 carbon atoms, in their enantiomeric or diastereoisomeric forms or mixtures of these forms, and/or, where appropriate, in their syn or anti form or a mixture thereof, as well as the salts thereof. 3 . A heterocyclylalkylpiperidine derivative as claimed in claim 1, characterized in that it is 4-[3-{3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(thien-2-yl)thioethyl]piperidine-4-carboxylic acid, as well as the salts thereof. 4. A heterocyclylalkylpiperidine derivative as claimed in claim 1, characterized in that it is 4-[3- (3-chloro-6-methoxyquinolin-4-yl)propyl]-l-[2-(3,5- difluorophenoxy)ethyl]piperidine-4-carboxylic acid, as well as the salts thereof. 5. A heterocyclylalkylpiperidine derivative as claimed in claim 1, characterized in that it is 4-[3- (3-chloro-6-methoxyquinolin-4-yl)propyl]-1-{2-thiazol-2- thioethyl)piperidine-4-carboxylic acid, as well as the salts thereof. 6. A heterocyclylalkylpiperidine derivative as claimed in claim 1, characterized in that it is l-(2- cyclopentylthioethyl)-4-[3-(3-fluoro-6-methoxyquinolin-4- yl)propyl]piperidine-4-carboxylic acid, as well as the salts thereof. 7. A heterocyclylalkylpiperidine derivative as claimed in claim 1, characterized in that it is 4-[3-(3- fluoro-6-methoxyc[uinolin-4-yl)propyl] -1- (3- phenylallyl)piperidine-4-carboxylic acid, as well as the salts thereof. 8. A process for preparing a heterocyclylalkylpiperidine derivative as claimed in claim 1, characterized in that the chain R3 defined in claim 1 is coupled with the heterocyclylalkylpiperidine derivative of general formula: separation of the enantiomeric or diastereoisomeric forms and/or, where appropriate, of the syn or anti forms and optional conversion of the product obtained into a salt. 9. A process as claimed in claim 8, characterized in that the coupling of the chain R3 with the piperidine is carried out by the action of a derivative of general formula: R3-X in which R3 is defined as above and X represents a halogen atom, a methylsulfonyl radical, a trifluoromethylsulfonyl radical or a p-toluenesulfonyl radical. 10. A process as claimed in either of claims 8 and 9, characterized in that, when R3 represents a radical -alk-R°3 for which alk is an alkyl radical and R°3 represents a radical -C=C-Rd in which Rd is phenyl, phenylalkyl, heterocyclyl or mono- or bicyclic aromatic heterocyclylalkyl, the reaction is preferably carried out by coupling an alkynyl halide: HC=C-alk-X for which alk is defined as above and X is a halogen atom, and then substitution of the chain with a phenyl, phenylalkyl, heterocyclyl or heterocyclylalkyl radical. 11. A process as claimed in either of claims 8 and 9, characterized in that, when R3 represents a radical -alk-R^3 for which alk is an alkyl radical and R°3 represents a phenoxy, phenylthio, phenylamino, heterocyclyloxy, heterocyclylthio or heterocyclylamino radical in which the heterocyclyl portion is aromatic, the reaction is preferably carried out by constructing the chain stepwise by first condensing a chain HO-alk-X for which X is a halogen atom, and then by converting the hydroxyalkyl chain obtained into a haloalkyl, methanesulfonylalkyl or p-toluenesulfonylalkyl chain, and finally by reacting in basic medium with an aromatic derivative of structure Ar-ZH for which Ar is a phenyl or aromatic heterocyclyl radical and Z is a sulfur, oxygen or nitrogen atom. 12. A pharmaceutical composition, characterized in that it contains at least one derivative as claimed in claim 1, in pure form or in combination with one or more compatible and pharmaceutically acceptable diluents and/or adjuvants. 13. A freterocyclylalkyl piperidine clerivativ2s substantially as herein described and exemplified. 14, A pharmaceutical composition substantially as herein described and exemplified.

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0700-chenp-2003 claims-duplicate.pdf

0700-chenp-2003 description (complete)-duplicate-1.pdf

0700-chenp-2003 description (complete)-duplicate-2.pdf

0700-chenp-2003 description (complete)-duplicate-3.pdf

0700-chenp-2003 description (complete)-duplicate-4.pdf

0700-chenp-2003 description (complete)-duplicate-5.pdf

0700-chenp-2003 description (complete)-duplicate-6.pdf

0700-chenp-2003 description (complete)-duplicate-7.pdf

0700-chenp-2003 description (complete)-duplicate-8.pdf

0700-chenp-2003 description (complete)-duplicate.pdf

700-chenp-03.rtf

700-chenp-2003-claims.pdf

700-chenp-2003-correspondnece-others.pdf

700-chenp-2003-correspondnece-po.pdf

700-chenp-2003-description(complete).pdf

700-chenp-2003-form 1.pdf

700-chenp-2003-form 19.pdf

700-chenp-2003-form 3.pdf

700-chenp-2003-pct.pdf