Title of Invention	1-OXA-3-AZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PRODUCTION THEREOF
Abstract	The present invention relates to derivatives of 1-oxa-3-aza-dibenzoazulene class, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory actions, especially to the inhibition of tumour necrosis factor-&agr; (TNF-&agr;) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.

Title of Invention

1-OXA-3-AZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PRODUCTION THEREOF

Abstract

The present invention relates to derivatives of 1-oxa-3-aza-dibenzoazulene class, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory actions, especially to the inhibition of tumour necrosis factor-&agr; (TNF-&agr;) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.

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Patent Number

228640

Indian Patent Application Number

2523/CHENP/2004

PG Journal Number

12/2009

Publication Date

20-Mar-2009

Grant Date

05-Feb-2009

Date of Filing

09-Nov-2004

Name of Patentee

PLIVA - ISTRAZIVACKI INSTITUT d.o.o

Applicant Address

Prilaz baruna Filipovica 29, HR-10000 Zagreb,

Inventors:

#	Inventor's Name	Inventor's Address
1	MERCEP, Mladen	Majstora Radonje 10 HR-10000 Zagreb,
2	MESIC, Milan	Slavenskog 8, HR-10000 Zagreb,
3	PESIC, Dijana	Prokljanska 18, HR-22000 Sibenik,
4	BENKO, Iva	Dr. Dobrile 4, HR-10410 Velika Gorica,

PCT International Classification Number

C07D 498/04

PCT International Application Number

PCT/HR2003/00015

PCT International Filing date

2003-04-09

PCT Conventions:

#	PCT Application Number	Date of Convention	Priority Country
1	P20020304A	2002-04-10	Croatia