Title of Invention

PHARMACEUTICAL COMPOSITIONS COMPRISING VALSARTAN AND NEP INHIBITORS

Abstract The invention relates a pharmaceutical composition comprising a combination of (i) the AT 1- antagonist valsartan or a pharmaceutically acceptable salt thereof and (ii) a NEP inhibitor or a pharmaceutically acceptable salt thereof and optionally a pharmaceutically acceptable carrier and to a method for the treatment or prevention of a condition or disease selected frem the group consisting of hypertension, heart failure such as (acute and chronic) congestive heart failure, left ventricular dysfunction .and hypertrophic cardiomyopathy, diabetic cardiac myopathy, supraventricular and ventricular arrhythmias, atrial fibrillation, atrial flutter, detrimental vascular remodeling, myocardial infarction and its sequelae, atherosclerosis, angina (whether unstable or stable), renal insufficiency (diabetic and non- diabetic), heart failure, angina pectoris, diabetes, secondary aldosteronism, primary and secondary pulmonary hypertension, renal failure conditions, such as diabetic nephropathy, glomerulonephritis, scleroderma, glomerular sclerosis, proteinuria of primary renal disease, and also renal vascular hypertension, diabetic retinopathy, the management of other: vascular disorders, such as migraine, peripheral vascular disease, Raynaud's disease, luminal hyperplasia, cognitive dysfunction (such as Alzheimer's), glaucoma and stroke, comprising administering a therapeutically effective amount of the pharmaceutical composition to a mammal in need thereof.
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Documents:

1538-chenp-2004 abstract-duplicate.pdf

1538-chenp-2004 abstract.pdf

1538-chenp-2004 assignment.pdf

1538-chenp-2004 claims granted.pdf

1538-chenp-2004 claims-duplicate.pdf

1538-chenp-2004 claims.pdf

1538-chenp-2004 correspondence-others.pdf

1538-chenp-2004 correspondence-po.pdf

1538-chenp-2004 description (complete)-duplicate.pdf

1538-chenp-2004 description (complete).pdf

1538-chenp-2004 drawings.pdf

1538-chenp-2004 form-1.pdf

1538-chenp-2004 form-19.pdf

1538-chenp-2004 form-26.pdf

1538-chenp-2004 form-3.pdf

1538-chenp-2004 form-5.pdf

1538-chenp-2004 pct search report.pdf

1538-chenp-2004 pct.pdf

1538-chenp-2004 petition.pdf


Patent Number 229051
Indian Patent Application Number 1538/CHENP/2004
PG Journal Number 12/2009
Publication Date 20-Mar-2009
Grant Date 13-Feb-2009
Date of Filing 09-Jul-2004
Name of Patentee NOVARTIS AG
Applicant Address LICHTSTRASSE 35, CH-4056 BASEL,
Inventors:
# Inventor's Name Inventor's Address
1 WEBB, RANDY, LEE 17 HONEYMAN DRIVE, FLEMINGTON, NJ 08822,
2 KSANDER, GARY, MICHAEL 37 THE FLUME, AMHERST, NEW HAMPSHIRE 03031,
PCT International Classification Number A61K31/41
PCT International Application Number PCT/EP03/00415
PCT International Filing date 2003-01-16
PCT Conventions:
# PCT Application Number Date of Convention Priority Country
1 60/349,660 2002-01-17 U.S.A.