| Title of Invention | A PROCESS FOR THE SYNTHESIS OF A SYNTHETIC POLYPEPTIDE ANALOG OF PARATHYROID HORMONES |
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| Abstract | The present invention relates to; A process for the synthesis of a synlt1etlc polypeptide analog of parathyroid ~e (PTH) or parathyroid homme related peptide (PTHrP). or a salt there-of, In which amino acid residues (22-31)selected from (SEa 10 NOS: 85. 86,26,27,28,29, and 30) form an amphtpathica-hellx, which processoompr1ses: a) independently synthesizing three precU1'8Or peptide fragments: an N-termlnus, a mkjdle. and a C-terminu6 fragment, wherein the N-terminus fragment has a C-termlnal glycine, the middle fragment has a C-terminal leucine, and the C-terminus fragment has an N-tem1lnalleuclne. b) cleaving all but the I1tended ultimate c..termlnal precursor peptide fragment of the des/red polypeptide from their respective resn suppOrts; c) sequentially condensing said cleaved precursor peptide fragments with the resin bound c..terminal peptide fragment to form the desired polypeptide product; d) removing side chain protecting groups; and e) cleaving the polypeptkje prodoot from the resin support. |
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1568-mas-1997 claims granted.pdf
1568-mas-1997 correspondence others.pdf
1568-mas-1997 correspondence po.pdf
1568-mas-1997 description (complete) granted-1.pdf
1568-mas-1997 description (complete) granted.pdf
1568-mas-1997 power of attorney.pdf
| Patent Number | 229143 | ||||||||
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| Indian Patent Application Number | 1568/MAS/1997 | ||||||||
| PG Journal Number | 12/2009 | ||||||||
| Publication Date | 20-Mar-2009 | ||||||||
| Grant Date | 13-Feb-2009 | ||||||||
| Date of Filing | 11-Jul-1997 | ||||||||
| Name of Patentee | F. HOFFMANN-LA ROCHE AG | ||||||||
| Applicant Address | 124 GRENZACHERSTRASSE, CH-4070 BASLE, | ||||||||
Inventors:
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| PCT International Classification Number | A61K038/80 | ||||||||
| PCT International Application Number | N/A | ||||||||
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PCT Conventions:
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