Title of Invention

2-CYANOPYRROLOPYRIMIDINES AND PROCESS FOR PREPARING THE SAME

Abstract

The invention relates to pyrrolo pyrimidines of formula (I), wherein Y represents -(CH2)t-0- or -(CH2)r-S-, p is 1 or 2, r is 1, 2 or 3, t is 1, 2 or 3, or Y is -(CH2)j- or -CH=CH-, j is 1 or 2; p is 1 or 2, or Y is -(CH2)f-, f is 1 or 2, p is 1, and the further radicals and symbols have the meaning as defined herein; their preparation, their use as pharmaceuticals, pharmaceutical compositions containing them, the use of such a compound for the manufacture of a pharmaceutical preparation for the treatment of neuropathic pain and to a method for the treatment of such a disease in animals, especially in humans.

Full Text

CLAIMS: 1. A pyrrolo pyrimidine of formula I, wherein Y represents -(CH2)rO- or -(CH2)rS-, p is 1 or 2, ris 1,2 or 3, t is 1,2 or 3, R1 represents (h) phenyl which is unsubstituted or mono-, di- or trisubstituted by (a) halogen, carboxy, alkoxy, nitro, alkyl-C(0)-NH-, cyc!oalkyl-C(0)-NH-, alkyl-C(O)-N(alkyl)-, formyl, alkyl-C(O)-, alkyl-S(0)2-NH-, CF3-alkyl-S(0)2-NH-, pyrrolidinyl carbonyl, piperidinyl carbonyl, morpholinyl carbonyl, N-alkyl piperazinyl carbonyl, piperidinyl, 1-(alkyl carbonyl) piperidinyl, 1,2,3,6-tetrahydropyridyl, alkyl carbonyl 1,2,3,6-tetrahydropyridyl, piperazinyl, alkyl piperazinyl, alkyl carbonyl piperazinyl, cycloalkyl carbonyl piperazinyl, alkoxy carbonyl piperazinyl, alkyl-S02-piperazinylf diazacycloheptyl, alkyl carbonyl diazacycloheptyl, 2-oxo-1-pyrrolidinyl, 3,3-di-alkyl-2-oxo-1-pyrrolidinyl; (P) R3-alkyl, wherein R3 represents hydrogen, hydroxy, carboxy, alkyl-N(alkyl)-, all^yl-NH-, 1-pyrrolidinyl, 1-piperidyl, 4-alkyl-1-piperazinyl carbonyl, 2,4-dioxa-5,5-(di-alkyl)-oxazolidin-3-yl, R4R5N-C(0)-, wherein R4 and R5 independently of each other represent hydrogen or alkyl; or (y) RaR7N-C(0)-, wherein R6 and R7 independently of each other represent hydrogen, alkyl, cycloalkyl alkyl, CF3-alkyl or pyridyl alkyl; (i) pyridyl, which is unsubstituted or mono-, di- or trisubstituted by halogen or alkyl which is mono-, di- or trisubstituted by halogen; (j) pyrimidyl; (k) indoiyl, which is mono^ or disubstituted by alkyl-C(0)-NH-alkyl; (I) 2-(alkyl)-benzothiazolyl; (m)a radical of subformula la wherein Ra IS hydrogen, halogen or alkyl, R9 is hydrogen or alkyl, and m h 1, 2, 3 or 4; or (n) a radical of subformula lb wherein R10 is hydrogen, halogen or alkyl, Rn is hydrogen or alkyl, and n is 1,2, 3 or 4; R2 represents alkyl, which is unsubstituted or substituted by cycloalkyl, which is unsubstituted or mono- or disubstituted by halogen, or phenyl, which Is mono- or disubstituted by halogen; under the proviso that R2 does not represent 1,1-dimethylethyl if Y is O and R^ is selected from 3-pyridyl, 4-pyrldyl, 5-chioro-3-pyridyl, 6-chloro-3-pyridyl, 2-chloro-4-pyridyl, 2- trifluoromethyl-4-pyridyl, 2-difluoromethyl-4-pyridyl, 4-acetyl-1-piperazinyl-phenyl, 4- methyl-1-piperazinyl-methyl-phenyl,and under the proviso that R2 does not represent 1,1-dimethylethyl, if Y is S and Ri is 4-pyridyl; or Yis^CH2)ror-~CH=CH-, jis1or2; p is 1 or 2, Ri represents (c) thienyl, thiazolyl, 1-piperidinyl-carbonyl, or (d) phenyl which is unsubstituted or mono-, di- or trisubstituted by (i) alkoxy, H2N-C(0)-, 4-(alkyl carbonyl) 1-piperazinyl, 2-oxo-1-pyrrolidinyl, or halogen; (ii) Ri2-0-C(0)-t wherein Ri2is hydrogen or alkyl, or (iii) R13NH-, wherein R13 represents hydrogen or a radical R14-alkyl-Z-, wherein Z is CO, SO or S02 and R14 denotes hydrogen, trifluoromethyl or alkoxy, (iv) Ri5-alkyl, wherein R15 denotes hydrogen, hydroxy, lalkoxy, 1-pyrrolidinyl, 2-oxo-1- pyrrolidinyl, imidazolidin-2,5-dion-1-yl, 5,5-di-alkyI-oxazolidin-2,4-dion-3-yl or alkyl- M(R™)-> wherein Ri6 represents hydrogen or alkyi; and •'* ■■■!i- ..-•■■■■■■■.-■ R2 represents (a) alkyl, which is unsubstituted or substituted by alkenyl, indanyl, cycloalkyl which is unsubstituted or mono- or disubstituted by halogen or alkyl, cycloalkenyl, phenyl, which is unsubstituted or mono- or disubstituted by halogen or by alkyl; (b) cycloalkyl; or (c) alkylcarbonyl; under the proviso that, if Y is CH2) Ri represents 4-chlorophenyl and p is 1, R2 does not denote 1,1-dimethylethyl, 1-methylethyl, cyclopropyl, cyclohexyl, 2-methyl-propyl or 2-ethyl-propyl; under the proviso that R2 does not represent 1,1-dimethylethyl, if p is 1, Y is CH2 and R, represents thienyl, phenyl, methoxyphenyl, propoxyphenyl, 4-fluorophenyl, 4-methylphenyl, 4-ethylphenyl, 4-butylphenyl, hydroxymethylphenyl, 4-(5,5-dimethyl-oxazolidin-2,4-dion-3-yl-methyl)-phenylf 4-(methylsulfonylamino)-phenyl,4-(n-butyl-sulfonylamino)-phenyl, 4-(ethylsulfonylamino)-phenyl, 4-(n-propyIsulfonylamino)-phenyl, 4-(iso-propylsulfonylamino)-phenyl, 4-aminophenyl, 4-(acetylamino)-phenyl, 4-(butanoylamino)-phenyl or 4-(diethylaminomethyl)-phenyl; and under the proviso that that R2 does not represent 1-methylethyl, if p is 1, Y is CH2 and Ri represents phenyl which is unsubstituted or substituted by 4-acetyl-1-piperazinyl; or Y is - fis1or2; pis1f Ri represents (a) 1,2,3,6-tetrahydropyrkM-yl, alW-1.2,3,6-tetrahydropyrid-1-ylf di-alkyl-1,2,3,6-tetrahydropyrid-1-yl, halo-1,2,3,6-tetrahydropyrid-1-yl, phenyl-1,2,3,6-tetrahydropyrid-1-yl, imidazolyl, alkyl imidazolyl, di-halo imidazolyl, imidazolidin-2,5-dion-1-yl, 5,5-dilalkyl-oxazolidin-2,4-dion-3-yl, alkyl imidazolidin-2,5-dion-1-yl, trifluoromethyl-3,4-pyrrolin-1-yl, pyrrolidinyl, alkyl 1-pyrrolidinyl, di-alkyl) pyrrolidinyl, alkoxy pyrrolidinyl, alkyl 2-oxo-1-pynrolidinyl, di-alkyl 2-oxo-1-pyrrolidinyl, halo 1-pyrrolidinyl, di-halo 1-pyrrolidinyl, di-halo 1-piperidinyl, triazolyl, nitro triazolyl, phenyl imidazolyl, tetrazolyl, benzo[b]imidazolyl, (1-(alkyl-S02)-4-piperidinyl)-2,3-dihydro-2-oxo-benzo[b]imidazolyl, 3-(alkyl carbonyl-4-piperidinyl)-2,3-dihydro-2-oxo-benzo[b]imidazolylt indolyl, halo 1-indolyl, 1,3-dihydro-2-isoinddlyl, 2,3-dihydro-1-indolyl, 2,3-dlhydro-2-oxo-benzo[b]thiazolyl, di-alkoxv 1,2,3,4-tetrahydroquinnolin, alkoxy-1,2,3,4-tetrahydroisoquinnolin; (b) a radical of substructure Ic which is bound to the molecule via the nitrogen atom, wherein X is -0-, -(CH2)s-CRi7Rie- or -NR18, wherein s is 0,1 or 2, R17 and R18 are independently selected from hydrogen, halogen, hydroxy, alkyl, phenyl alkyl carbonyl, carbamoyl, N-phenyl carbamoyl, cyano, pyridyl, piperidinyl and phenyl which is unsubstituted or mono- or disubstituted by halogen or alkoxy, or, if X is CR|7R18, Ri7 and R18 and together form an oxo group or a group HO-C(0)-CH=, and R23t R24, R25 and R26 are independently selected from hydrogen and alkyl; (c) a radical of substructure Id which is bound to the molecule via the nitrogen atom, wherein k is 0,1 or 2, A is CH2 or a bond, B is CH2 or carbonyl, D is CH2 or carbonyl, E is CH2 or NR^, G is CH2 or a bond, Q is CH2 or carbonyl, T is CH2 or NR29, R19 represents hydrogen, alkyl, phenyl alkyl, alkyl carbonyl or alkyl-S02-f R^ is hydrogen or alkyl and R29 isphenvl; (d) a radical of substructure le which is bound to the molecule via the nitrogen atom, wherein R27 is alkyl or alkyl carbonyl and R28 is hydrogen, alkoxy or halogen; or (e) NR^R^, wherein R2o and R21 are independently selected from hydrogen, alkyl, cycloalkyl which is unsubstituted or mono- or disubstituted by hydroxy; and phenyl which is unsubstituted or mono- or disubstituted by 1,2,3-thiadiazolyl, under the proviso that not both R^ and R2i can represent hydrogen at the same time; and R2 denotes alkyl, which is unsubstituted or substituted by cycloalkyl which is unsubstituted or mono- or disubstituted by halogen; or phenyl, which is mono- or disubstituted by halogen; under the proviso that R2 does not represent 1,1-dimethylethyl, if (a) Ri is benzo[b]imidazol-1-yI, 1-imidazolyI, 4,5-dichloro-1-imidazolyl, a-fC^alkylJ-l-imidazolyl, imidazolidin-2,5-dion-1-yl, 5,5-dimethyl-oxazolidin-2,4-dion-3~yl, 1H-1,2,3-triazol-1-yl, 2H-1,2,3-triazol-2-yl> 3-nitro-1H-1,2,4-triazoM-yl, 2H-tetrazol-2-yl or 1H-tetrazol-1-yl, or if Ri is a radical of substructure Ic, R23 to R26 are hydrogen, X is NR18 and R18 is hydrogen, methyl, ethyl, acetyl, 4-pyridyl, 1-piperidinyl, phenyl, methoxyphenyl, ethoxyphenyl, fluorophenyl or chlorophenyl; (b) Ri is a radical of substructure lcF R23 to R& are hydrogen, X is -(CH2)S-CR17R18~, s is 0, and R17 and R18 are selected from hydroxyl and phenyl which is monosubstituted by chloro or R17 and R18 are selected from hydrogen, methoxyphenyl and N-phenyl-carbamoyl; or (c) Ri is a radical of substructure Id, k is 1, A is a bond, E is NR22, R22 is hydrogen, G, Q and T are CH2, B and D are carbonyl and R19 is methyl, n-propyl or iso-butyl; under the proviso that R2 does not represent 2-methylpropyl, if Ri is a radical of substructure Id, k is 1, A is a bond, E is NR22, R^ is hydrogen, G, Q and T are CH2, B and D are carbonyl and R19 is methyl, or if Ri is a radical of substructure Ic, R23 to R26 are hydrogen, X is -(CH2)s-CR17Ri8-» s is 0, and R17 and R18 are selected from hydrogen and phenyl which is monosubstituted hy methoxy; i and under the proviso that R2 does not represent 1-methylethyl, if Rt is a radical of substructure Ic, R23 to R26 are hydrogen, X is NR18 and R18 is methoxyphenyl or ethoxyphenyl, orX is CR17R18 and R17 and R18 are selected from hydrogen and methoxyphenyl; or an N-oxide or a tautomer thereof, or a salt of such pyrrolo pyrimidine, its N-oxide or its tautomer. 2. A pyrrolo pyrimidine of formula I according^ to claim 1, wherein Y represents -CH2-0- or -CH2-S-, pis 1, Ri represents (0) phenyl which is unsubstituted or mono- or disubstituted by (a) halogen, carboxy, CrC4alkoxy, nitro, CrC4alkyl-C(0)-NH-, C3-C4cycloalkyl-C(0)-NH-, Ci-C4alkyl-C(0)-N(CrC4alkyl)-, formyl, d-Gjalkyl-C^O)-, CrC4alkyl-S(0)2-NH-f CFs-CrCaalkyl-SCOVNH-, 1-pyrrolidinyl-carbonyl, 1-piperidinyl-carbonyl, 4-morpholinyl-carbonyl, 4-(CrC4alkyl)-1-piperazinyl carbonyl, 4-piperidinyl, 1-piperidinyl, l-CCi-C^lkyl-carbonylH-piperidinyl, 1f2,3,6-tetrahydro-4-pyridyl, 1-(Cr C4alkyl-carbonyl)-1,2,3,6-tetrahydro-4-pyridyl, 1-piperazinyl, 4-(CrC4alkyl)-1-piperazinyl, 4-(CrC4alkyl-carbonyl)-1 -piperazinyl, 4-(C3-C5cycloalkyl-carbonyl)-1-piperazinyl, 4-(C1-C4alkoxy-carbonyl)-1 -piperazinyl, 4-(CrC4alkyl-S02)-1 -piperazinyl, 1,4-diazacyclohept-1 -yl, 4-(CrC4alkyl-carbonyl)-1,4-diazacyclohept-1 -yl, 2-oxo-1 -Ryrrolidinyl,3>3-di-(CrC4alkyl)-2-oxo-1-pyrrolidinyl; (P) R3-CrC4alkyl, wherein R3 represents hydrogen, hydroxyl, carboxy, Ci-C4alkyl-N(CrC4alky!)-, CrC4alkyl-NH-, 1-pyrrolidinyl, 1-piperidyl, 4-(CrC4alkyl)-1-piperazinyl carbonyl, 2f4-dioxa-5l5-(di-CrC4alkyl)-oxa2olJdin-3-yl> RiRsN-CKO)-, wherein R4 and R5 independently of each other represent hydrogen or CrC4alkyl; or (y) ReR7N-C(0)-, wherein R6 and R7 independently of each other represent hydrogen, CrC4alkyl, C5-C7cycloalkyl-CrC4aIkyl, CF3-CrC3alkyl or pyridyl-CrC4alkyl; (p) pyridyl, which is unsubstituted or mono- or disubstituted by halogen or CrC4aIkyI which is di- or trisubstituted by halogen; (q) pyrimidyl; (r) indolyl, which is monosubstituted by CrC4alkyl-C(0)-NH-CrC4alkyl; (s) Z-CCrC^lkyO-benzothiazolyl; (t) a radical of subformula la wherein R& is hydrogen, R9 is hydrogen, and m is 2 or 3; or (u) a radical of subformula lb wherein Rio is hydrogen, Rn is hydrogen, and n is 2 or 3; R2 represents Ci-Csalkyl, which is unsubstituted or substituted by Cs-Cycycloalkyl, which is unsubstituted or disubstituted by halogen, or phenyl, which is mono- or disubstituted by halogen; under the proviso that R2 does not represent 1,1-dimethylethyl if Y is O and R, is selected from 3-pyridyl, 4-pyridyl, 5-chlon>3-pyridyl, 6-chloro-3-pyridyl, 2-chloro-4-pyridyl> 2-trifluoromethyl-4-pyridyl, 2-difluoromethyl-4-pyridylf 4-acetyH-piperazinyl-phenyl, 4-methyl-1-piperazinyl-methyl-phenylf and under the proviso that R2 does not represent 1,1-dimethylethyl, if Y is S and R1 is 4-pyridyl; or Y is CH2 or -CH=CH-, p is 1 or 2, -Ri represents (e) thienyl, thiazolyl, 1-piperidinyl-carbonyl, or (f) phenyl which is unsubstituted or mono- or disubstituted by (i) CrC4alkoxy, H2N-C(0)-, 4-(CrC4alkyl-carbonyl)-1-piperazinyl, 2-oxo-1-pyrrolidinyl, or halogen; (ii) Ri2-0-C(0)-, wherein Ri2is hydrogen or CrC4alkylf or (iji) Ri3NH-f wherein Ri3 represents hydrogen or a radical Ri4-CrC4alkyl-Z-, wherein Z is CO or S02 and R14 denotes hydrogen, trifluoromethyl or CrC4alkoxy, (Iv) Ri5-C1-C4alkyl, wherein R15 denotes hydrogen, hydroxy, lower alkoxy, 1-pyrrolidinyl, 2-oxo-1-pyrroIidinyl, imidazolidin-2,5-dion-1-yl, 5,5-dimethyl-oxazolidin-2,4-dion-3-yl or CrC4alkyl-N(R16)-, wherein R10 represents hydrogen or CrC4alkyl; and R2 represents (a) CrCyalkyl, which is unsubstituted or substituted by C2-C3alkenylf indanyl, C3-C7cycloalkyl which is unsubstituted or disubstituted by halogen or Ci-C4alkylv C3-C/cycloalkenyl, phenyl, which is unsubstituted or moro- or disubstituted by halogen or by Ci-C4alkyl; (b) QrCycycloalkyl; or (c) d*-C4alkylcarbonyI; under the proviso that, if Y is CH2, Ri represents 4-chlorophenyl and p is 1, R2 does not denote 1,1-dimethylethyI, 1-methylethyl, cyclopropyl, cyclohexyl, 2-methyl-propyl or 2-ethyl-propyl; under the proviso that R2 does not represent 1,1-dimethylethyl, if p is 1, Y is CH2 and R^ represents thienyl, phenyl, methoxyphenyl, propoxyphenyl, 4-fluorophenyl, 4-methylphenyl, 4-ethylphenyl, 4-butylphenyl, hydroxymethylphenyl, 4-(5,5-dimethyl-oxazolidin-2,4-dion-3-yl-methyl)-phenyl, 4-(methylsulfonylamino)-phenyl, 4-(n-butyl-sulfonylamino)-phenyl, 4-(ethylsulfonylamino)-phenyl,4-(n-propylsulfonylamino)-phenylf 4-(iso-propylsulfonylamino)-phenyl, 4-aminophenyl, 4-(acetylamino)-phenyl, 4-(butanoylamino)-phenyl or 4-(diethylaminomethyl)-phenyl; and under the proviso that that R2 does not represent 1-methylethyl, if p is 1, Y is CH2 and Ri represents phenyl which is unsubstituted or substituted by 4-acetyI-1-piperazinyl; or Y is CH2, p is 1, Ri represents (a) 1,2,3,6-tetrahydropyrid-1-yl, 4-(CrC4alkyl)-1,2f3,6-tetrahydropyrid-1-yl, 4,5-di(Cr C4a!kyl)-1,2,3,6-tetrahydropyrid-1-yl, 5-chloro-1,2,3f6-tetrahydropyrid-1-yl,4-phenyl-1,2,3,6-tetrahydropyrid-1-yl, Inmidazolyl, 2-(CrC4alkyl)-1-imidazolylf 4,5-dihalo-1-imidazolyl, imidazolidin-2,5 imidazolidin-2,5-dion-1 -yl, 3-trifluoromethyl-3,4-pyrrolin-1 -yl, 1 -pyrrolidinyl, 3-CrC4alkyl-1 -pyrrolidinyl, 3f3-di-(CrC4alkyl)-1-py.rrolidinyl, 3-CrC4alkoxy-1 -pyrrolidinyl, 3-C1-C4alkyl-2-oxo-1-pyrrolidinyl, 3,3"di-(C1-C4alkyl)-2-oxo-1-pyrrolidinyl, 3-halo-1 -pyrrolidinyl, 3,3-di-halo-1-pyrrolidinyl, 3,3-di-ha!o-1-piperidinyl, 1H-1,2,3-triazoM-yl, 2H-1,2f3-triazol-2-yl, 1H-1,2f4-triazol-1-yl, 3-nitro-1H-1,2,4-triazoi-1-yl, 2-phenyM-imidazolyl, 2H-tetrazol-2-yl, 1H-tetrazol-1 -yl, benzo[b]imidazol-1 -yl, 3-(1 -(C1-C4alkyl-S02)-4-piperidinyl)-2l3-dihydro-2-oxo-benzo[b]imidazol-1-yl, 3-(1-CrC4alkylcarbonyl-4-piperidinyl)-2,3-dihydro-2»oxo-benzo[b]imidazoM-yl, 1-indolyI, 6-halo-1-indolyl, 1,3-dihydro-2-isoindolyl, 2,3-dihydro-1-indolyl, 2,3-dihydro-2-oxo-benzo[b]thiazol-3yl, 6f7-di-(CrC4alkoxy)-1,2,3,4-tetrahydroquinnolin, 6-CrC4alkoxy-1,2,3,4-tetrahydroisoquinnolin, 7-CrC4alkoxy-1,2,3,4-tetrahvdroisoquinnolin; (b) a radical of substructure Ic which is bound to the molecule via the nitrogen atom, wherein X is -©-, -(CH2)S-CR17RIB- or -NR18, wherein s is 0 or 1, R17 and R18 are independently selected from hydrogen, halogen, hydroxy, d- C4alkyl, phenyl-CrC4alkyl-carbonyl, carbamoyl, N-phenyl-carbamoyl, cyano, 4-pyridyl, 1- piperidinyl and phenyl which is unsubstituted or monosubstituted by halogen or Cr C4alkoxy, or, if X is CR17R1B) R17 and R18 and together form an oxo group or a group HO- C(0)-CH=, and R23, R24, R25 and R26 are independently selected from hydrogen and CrC4alkyl; (c) a radical of substructure Id which is bound to the molecule via the nitrogen atom, wherein k is 0 or 1, A is CH2 or a bond, B is CH2 or carbonyl, D is CH2 or carbonyl, E is CH2 or NR^, G is CH2 or a bond, Q is CH2 or carbonyl, T is CH2 or NR29, R19 represents hydrogen, CrC4alkyl, phenyl-d-C4alkyl, CrC4alkylcarbonyl or CrC4alkyl-S02-, R^ is hydrogen and R29 is phenyl; (d) a radical of substructure le which is bound to the molecule via the nitrogen atom, wherein R27 is CrC4alkyl or CrC4alkylcarbonyl and R28 is hydrogen, Ci-C4alkoxy or halogen; or (e) NR20R2i, wherein R20 and R2? are independently selected from hydrogen, CrC4alkyI, C3-C7cycloalkyl which is unsubstituted or monosubstituted by hydroxy; and phenyl which is unsubstituted or monosubstituted by 1,2,3-thiadiazol-4-yl, under the proviso that not both R20 and R21 can represent hydrogen at the same time; and R2 denotes Ci-C8alkyl, which is unsubstituted or substituted by C3-C7cycloalkyi which is unsubstituted or disubstituted by halogen; phenyl, which is mono- or disubstituted by halogen; . under the proviso that R2 does not represent 1,1-dimethyIethyl, if (a) Ri is benzo[b]imidazol-1-yl, 1-imidazolyl, 4f5-dichloro-1-imidazolyl, 2-(CrC4alkyl)-1-imidazolyl, imidazolidin-2,5-dion-1-yl, 5,5-dimethyl-oxazoIidin-2,4-dion-3-yl, 1H-1,2,3-triazol-1-yl, 2H-1,2,3-triazol-2-yl, S-nitro-IH-l^-triazoM-yl, 2H-tetrazol-2-yl or 1H-tetrazol-1-yl, or if Rt is a radical of substructure lc, R23 to R26 are hydrogen, X is NR18 and RIB is hydrogen, methyl, ethyl, acetyl, 4-pyridyi, 1-piperidinyl, phenyl, methoxyphenyl, ethoxyphenyl, fluorophenyl or chlorophenyl; (b) R, is a radical of substructure !c, R2S to R23 aro hydrogen, X Is -(r-H2}s CRi7R*B-i * is 0, and R17 and Ri8 are selected from hydroxyl and phenyl which is monosubstituted by chloro or Ri7 and R18 are selected from hydrogen, methoxyphenyl and N-phenyl-carbarnoyl; or (c) Ri is a radical of substructure Id, k is 1, A is a bond, E is NR^, R22 is hydrogen, G, Q and T are CH2, B and D are carbonyl and R19 is methyl, n-propyl or iso-butyl; under the proviso that R2 does not represent 2-methylpropyl, if R^ is a radical of substructure Id, k is 1, A is a bond, E is NR22, R22 is hydrogen, G, Q and T are CH2, B and D are carbonyl and R19 is methyl, or if Ri is a radical of substructure lc, R23 to R26 are hydrogen, X is "(CH2)S-CR17R18-, s is 0, and Ri7 and R18 are selected from hydrogen and phenyl which is monosubstituted by methoxy; and under the proviso that R2 does not represent 1-methyiethyl, if R1 is a radical of substructure lc, R23 to R26 are hydrogen, X is NRi8 and R18 is methoxyphenyl or ethoxyphenyl, or X is CRi7R18 and R17 and R?8 are selected from hydrogen and methoxyphenyl; or a tautomer thereof, or a salt of such pyrrolo pyrimidine or its tautomer. ♦3. A pyrrolo pyrimidine of formula I according to claim 1 or 2, or an N-oxide or a tautomer thereof, or a pharmaceutical^ acceptable salt of such a compound, for use in a method for the treatment of the human or animal body. 4. Use of a pyrrolo pyrimidine of formula I according to claim 1 or 2, or an N-oxide or a tautomer thereof, or a pharmaceutically acceptable salt of such a compound, for the preparation of a pharmaceutical product for the treatment of neuropathic pain. 5. A method for the treatment of neuropathic pain, which comprises administering a pyrrolo pyrimidine of formula I according to claim 1 or 2, or a N-oxide or a tautomer thereof, or a pharmaceutically acceptable salt thereof, its N-oxide or its tautomer, in a quantity effective against said disease, to a warm-blooded animal requiring such treatment. 6. A pharmaceutical preparation, comprising a pyrrolo pyrimidine of formula I according to claim t or 2, or an N-oxide or a tautomer thereof, or a pharmaceutically acceptable salt of such a compound, or a hydrate or solvate thereof, and at least one pharmaceutically acceptable carrier. 7. A process for the preparation of a pyrrolo pyrimidine of formula I wherein Y represents -(CH2)rO- or (CH2)r-S- p is 1 or 2, ris 1,2 or 3, tis1,2or3, fy represents (v) phenyl which is unsubstituted or mono-, di- or trisubstituted by (a) halogen, carboxy, alkoxy, nitro, alkyl-C(0)-NH-, cycIoaIkyl-G(0)-NH-, alkyl-C(O)-N(alkyl)-( formyl, alkyl-C(O)-, alkyl-S(0)2-NH-t CF3-alkyl-S(0)2-NH-f pyrrolidinyl carbonyl, piperidinyl carbonyl, morpholinyl carbonyl, N-alkyl piperazinyl carbonyl, piperidinyl, 1-(alkyl carbonyl) piperidinyl, 1,2,3,6-tetrahydropyridyl, alkyl carbonyl 1,2,3,6-tetrahydropyridyl, piperazinyl, alkyl piperazinyl, alkyl carbonyl piperazinyl, cycloalkyl carbonyl piperazinyl, alkoxy carbonyl piperazinyl, alkyl-S02-plperazinyl, diazacycloheptyl, alkyl carbonyl diazacycloheptyl, 2-oxo-1 -pyrrolidinyl, 3,3-di-alkyl-2- oxo-1-pyrrolidinyl; (P) fValkyl, wherein R3 represents hydrogen, hydroxy, carboxy, alkyl-N(alkyl)-, alkyl- NH-, 1-pynrolidinyl, 1-piperidyl, 4-aikyl-1-piperazinyl carbonyl, 2,4-dioxa-5,5-(di-alkyl)- oxazolidin-3-yl, R4R5N-C(0)-, wherein R4 and R5 independently of each other represent hydrogen or alkyl; or (y) ReR7N-C(0)-( wherein R6 and R7 independently of each other represent hydrogen, alkyl, cycloalkyl alkyl, CF3-alkyl or pyridyl alkyl; (w) pyridyl, which Is unsubstituted or mono-, di- or trisubstituted by halogen or alkyl which is mono-, di- or trisubstituted by halogen; (x) pyrimidyl; (y) »ndolyl, which is mono- or disubstituted by aIkyl-C(0)-NH-a!kyl;. (z) 2-(alkyl)-benzothiazolyl; (aa) a radical of subformula la wherein R8 is hydrogen, halogen or alkyl, R9 is hydrogen or alkyl, and m is 1, 2, 3 or 4; or (bb) a radical of subformula lb wherein Rio is hydrogen, halogen or alkyl, Rn is hydrogen or alkyl, and n is 1,2, 3 01 4; R2 represents alkyl, which is unsubstituted or substituted by cycloalkyl, which is unsubstituted or mono- or disubstituted by halogen, or phenyl, which is mono- or disubstituted by halogen; under the proviso that R2 does not represent 1,1-dimethylethyl if Y is O and fy is selected from 3-pyridyl, 4-pyridyl, 5-chloro-3-pyridyl, 6-chloro-3-pyridyl, 2-chloro-4-pyridyl, 2-trifIuoromethyl-4-pyridyI, 2-difluoromethyl-4-pyridyl, 4-acetyM-piperazinyl-phenyl, 4-methyl-1 -piperazinyl-methyl-phenyl, and under the proviso that R2 does not represent 1,1-dimethylethyl, if Y is S and Ri is 4-pyridyl; wherein an alcohol or a thiol of formula llv Rr(Y)p-H (II) wherein Y represents -(CH2)rO- or (CH2)rS- and t, r and R^ have the meanings as provided above for a compound of formula I, is alkylated with a pyrrolp pyrimidine of formula Si I wherein R2 has the meaning as provided above for a compound of formula I and Hal denotes halo, preferably bromo, wherein the starting compounds of formula II and III may also be present with functional groups in protected form, if necessary, and/or in the form of salts, provided a salt-forming group is present and the reaction in salt form is possible; wherein any protecting groups in a protected derivative of a compound of the formula I are removed; and, if so desired, an obtainable compound of formula I is converted into another compound of formula I or a N-oxide thereof, a free compound of formula I is converted into a salt, an obtainable salt of a compound of formula I is converted into the free compound or another salt, and/or a mixture of isomeric compounds of formula I is separated into the individual isomers. CLAIMS: 1. A pyrrolo pyrimidine of formula I, wherein Y represents -(CH2)rO- or -(CH2)rS-, p is 1 or 2, ris 1,2 or 3, t is 1,2 or 3, R1 represents (h) phenyl which is unsubstituted or mono-, di- or trisubstituted by (a) halogen, carboxy, alkoxy, nitro, alkyl-C(0)-NH-, cyc!oalkyl-C(0)-NH-, alkyl-C(O)-N(alkyl)-, formyl, alkyl-C(O)-, alkyl-S(0)2-NH-, CF3-alkyl-S(0)2-NH-, pyrrolidinyl carbonyl, piperidinyl carbonyl, morpholinyl carbonyl, N-alkyl piperazinyl carbonyl, piperidinyl, 1-(alkyl carbonyl) piperidinyl, 1,2,3,6-tetrahydropyridyl, alkyl carbonyl 1,2,3,6-tetrahydropyridyl, piperazinyl, alkyl piperazinyl, alkyl carbonyl piperazinyl, cycloalkyl carbonyl piperazinyl, alkoxy carbonyl piperazinyl, alkyl-S02-piperazinylf diazacycloheptyl, alkyl carbonyl diazacycloheptyl, 2-oxo-1-pyrrolidinyl, 3,3-di-alkyl-2-oxo-1-pyrrolidinyl; (P) R3-alkyl, wherein R3 represents hydrogen, hydroxy, carboxy, alkyl-N(alkyl)-, all^yl-NH-, 1-pyrrolidinyl, 1-piperidyl, 4-alkyl-1-piperazinyl carbonyl, 2,4-dioxa-5,5-(di-alkyl)-oxazolidin-3-yl, R4R5N-C(0)-, wherein R4 and R5 independently of each other represent hydrogen or alkyl; or (y) RaR7N-C(0)-, wherein R6 and R7 independently of each other represent hydrogen, alkyl, cycloalkyl alkyl, CF3-alkyl or pyridyl alkyl; (i) pyridyl, which is unsubstituted or mono-, di- or trisubstituted by halogen or alkyl which is mono-, di- or trisubstituted by halogen; (j) pyrimidyl; (k) indoiyl, which is mono^ or disubstituted by alkyl-C(0)-NH-alkyl; (I) 2-(alkyl)-benzothiazolyl; (m)a radical of subformula la wherein Ra IS hydrogen, halogen or alkyl, R9 is hydrogen or alkyl, and m h 1, 2, 3 or 4; or (n) a radical of subformula lb wherein R10 is hydrogen, halogen or alkyl, Rn is hydrogen or alkyl, and n is 1,2, 3 or 4; R2 represents alkyl, which is unsubstituted or substituted by cycloalkyl, which is unsubstituted or mono- or disubstituted by halogen, or phenyl, which Is mono- or disubstituted by halogen; under the proviso that R2 does not represent 1,1-dimethylethyl if Y is O and R^ is selected from 3-pyridyl, 4-pyrldyl, 5-chioro-3-pyridyl, 6-chloro-3-pyridyl, 2-chloro-4-pyridyl, 2- trifluoromethyl-4-pyridyl, 2-difluoromethyl-4-pyridyl, 4-acetyl-1-piperazinyl-phenyl, 4- methyl-1-piperazinyl-methyl-phenyl,and under the proviso that R2 does not represent 1,1-dimethylethyl, if Y is S and Ri is 4-pyridyl; or Yis^CH2)ror-~CH=CH-, jis1or2; p is 1 or 2, Ri represents (c) thienyl, thiazolyl, 1-piperidinyl-carbonyl, or (d) phenyl which is unsubstituted or mono-, di- or trisubstituted by (i) alkoxy, H2N-C(0)-, 4-(alkyl carbonyl) 1-piperazinyl, 2-oxo-1-pyrrolidinyl, or halogen; (ii) Ri2-0-C(0)-t wherein Ri2is hydrogen or alkyl, or (iii) R13NH-, wherein R13 represents hydrogen or a radical R14-alkyl-Z-, wherein Z is CO, SO or S02 and R14 denotes hydrogen, trifluoromethyl or alkoxy, (iv) Ri5-alkyl, wherein R15 denotes hydrogen, hydroxy, lalkoxy, 1-pyrrolidinyl, 2-oxo-1- pyrrolidinyl, imidazolidin-2,5-dion-1-yl, 5,5-di-alkyI-oxazolidin-2,4-dion-3-yl or alkyl- M(R™)-> wherein Ri6 represents hydrogen or alkyi; and •'* ■■■!i- ..-•■■■■■■■.-■ R2 represents (a) alkyl, which is unsubstituted or substituted by alkenyl, indanyl, cycloalkyl which is unsubstituted or mono- or disubstituted by halogen or alkyl, cycloalkenyl, phenyl, which is unsubstituted or mono- or disubstituted by halogen or by alkyl; (b) cycloalkyl; or (c) alkylcarbonyl; under the proviso that, if Y is CH2) Ri represents 4-chlorophenyl and p is 1, R2 does not denote 1,1-dimethylethyl, 1-methylethyl, cyclopropyl, cyclohexyl, 2-methyl-propyl or 2-ethyl-propyl; under the proviso that R2 does not represent 1,1-dimethylethyl, if p is 1, Y is CH2 and R, represents thienyl, phenyl, methoxyphenyl, propoxyphenyl, 4-fluorophenyl, 4-methylphenyl, 4-ethylphenyl, 4-butylphenyl, hydroxymethylphenyl, 4-(5,5-dimethyl-oxazolidin-2,4-dion-3-yl-methyl)-phenylf 4-(methylsulfonylamino)-phenyl,4-(n-butyl-sulfonylamino)-phenyl, 4-(ethylsulfonylamino)-phenyl, 4-(n-propyIsulfonylamino)-phenyl, 4-(iso-propylsulfonylamino)-phenyl, 4-aminophenyl, 4-(acetylamino)-phenyl, 4-(butanoylamino)-phenyl or 4-(diethylaminomethyl)-phenyl; and under the proviso that that R2 does not represent 1-methylethyl, if p is 1, Y is CH2 and Ri represents phenyl which is unsubstituted or substituted by 4-acetyl-1-piperazinyl; or Y is - fis1or2; pis1f Ri represents (a) 1,2,3,6-tetrahydropyrkM-yl, alW-1.2,3,6-tetrahydropyrid-1-ylf di-alkyl-1,2,3,6-tetrahydropyrid-1-yl, halo-1,2,3,6-tetrahydropyrid-1-yl, phenyl-1,2,3,6-tetrahydropyrid-1-yl, imidazolyl, alkyl imidazolyl, di-halo imidazolyl, imidazolidin-2,5-dion-1-yl, 5,5-dilalkyl-oxazolidin-2,4-dion-3-yl, alkyl imidazolidin-2,5-dion-1-yl, trifluoromethyl-3,4-pyrrolin-1-yl, pyrrolidinyl, alkyl 1-pyrrolidinyl, di-alkyl) pyrrolidinyl, alkoxy pyrrolidinyl, alkyl 2-oxo-1-pynrolidinyl, di-alkyl 2-oxo-1-pyrrolidinyl, halo 1-pyrrolidinyl, di-halo 1-pyrrolidinyl, di-halo 1-piperidinyl, triazolyl, nitro triazolyl, phenyl imidazolyl, tetrazolyl, benzo[b]imidazolyl, (1-(alkyl-S02)-4-piperidinyl)-2,3-dihydro-2-oxo-benzo[b]imidazolyl, 3-(alkyl carbonyl-4-piperidinyl)-2,3-dihydro-2-oxo-benzo[b]imidazolylt indolyl, halo 1-indolyl, 1,3-dihydro-2-isoinddlyl, 2,3-dihydro-1-indolyl, 2,3-dlhydro-2-oxo-benzo[b]thiazolyl, di-alkoxv 1,2,3,4-tetrahydroquinnolin, alkoxy-1,2,3,4-tetrahydroisoquinnolin; (b) a radical of substructure Ic which is bound to the molecule via the nitrogen atom, wherein X is -0-, -(CH2)s-CRi7Rie- or -NR18, wherein s is 0,1 or 2, R17 and R18 are independently selected from hydrogen, halogen, hydroxy, alkyl, phenyl alkyl carbonyl, carbamoyl, N-phenyl carbamoyl, cyano, pyridyl, piperidinyl and phenyl which is unsubstituted or mono- or disubstituted by halogen or alkoxy, or, if X is CR|7R18, Ri7 and R18 and together form an oxo group or a group HO-C(0)-CH=, and R23t R24, R25 and R26 are independently selected from hydrogen and alkyl; (c) a radical of substructure Id which is bound to the molecule via the nitrogen atom, wherein k is 0,1 or 2, A is CH2 or a bond, B is CH2 or carbonyl, D is CH2 or carbonyl, E is CH2 or NR^, G is CH2 or a bond, Q is CH2 or carbonyl, T is CH2 or NR29, R19 represents hydrogen, alkyl, phenyl alkyl, alkyl carbonyl or alkyl-S02-f R^ is hydrogen or alkyl and R29 isphenvl; (d) a radical of substructure le which is bound to the molecule via the nitrogen atom, wherein R27 is alkyl or alkyl carbonyl and R28 is hydrogen, alkoxy or halogen; or (e) NR^R^, wherein R2o and R21 are independently selected from hydrogen, alkyl, cycloalkyl which is unsubstituted or mono- or disubstituted by hydroxy; and phenyl which is unsubstituted or mono- or disubstituted by 1,2,3-thiadiazolyl, under the proviso that not both R^ and R2i can represent hydrogen at the same time; and R2 denotes alkyl, which is unsubstituted or substituted by cycloalkyl which is unsubstituted or mono- or disubstituted by halogen; or phenyl, which is mono- or disubstituted by halogen; under the proviso that R2 does not represent 1,1-dimethylethyl, if (a) Ri is benzo[b]imidazol-1-yI, 1-imidazolyI, 4,5-dichloro-1-imidazolyl, a-fC^alkylJ-l-imidazolyl, imidazolidin-2,5-dion-1-yl, 5,5-dimethyl-oxazolidin-2,4-dion-3~yl, 1H-1,2,3-triazol-1-yl, 2H-1,2,3-triazol-2-yl> 3-nitro-1H-1,2,4-triazoM-yl, 2H-tetrazol-2-yl or 1H-tetrazol-1-yl, or if Ri is a radical of substructure Ic, R23 to R26 are hydrogen, X is NR18 and R18 is hydrogen, methyl, ethyl, acetyl, 4-pyridyl, 1-piperidinyl, phenyl, methoxyphenyl, ethoxyphenyl, fluorophenyl or chlorophenyl; (b) Ri is a radical of substructure lcF R23 to R& are hydrogen, X is -(CH2)S-CR17R18~, s is 0, and R17 and R18 are selected from hydroxyl and phenyl which is monosubstituted by chloro or R17 and R18 are selected from hydrogen, methoxyphenyl and N-phenyl-carbamoyl; or (c) Ri is a radical of substructure Id, k is 1, A is a bond, E is NR22, R22 is hydrogen, G, Q and T are CH2, B and D are carbonyl and R19 is methyl, n-propyl or iso-butyl; under the proviso that R2 does not represent 2-methylpropyl, if Ri is a radical of substructure Id, k is 1, A is a bond, E is NR22, R^ is hydrogen, G, Q and T are CH2, B and D are carbonyl and R19 is methyl, or if Ri is a radical of substructure Ic, R23 to R26 are hydrogen, X is -(CH2)s-CR17Ri8-» s is 0, and R17 and R18 are selected from hydrogen and phenyl which is monosubstituted hy methoxy; i and under the proviso that R2 does not represent 1-methylethyl, if Rt is a radical of substructure Ic, R23 to R26 are hydrogen, X is NR18 and R18 is methoxyphenyl or ethoxyphenyl, orX is CR17R18 and R17 and R18 are selected from hydrogen and methoxyphenyl; or an N-oxide or a tautomer thereof, or a salt of such pyrrolo pyrimidine, its N-oxide or its tautomer. 2. A pyrrolo pyrimidine of formula I according^ to claim 1, wherein Y represents -CH2-0- or -CH2-S-, pis 1, Ri represents (0) phenyl which is unsubstituted or mono- or disubstituted by (a) halogen, carboxy, CrC4alkoxy, nitro, CrC4alkyl-C(0)-NH-, C3-C4cycloalkyl-C(0)-NH-, Ci-C4alkyl-C(0)-N(CrC4alkyl)-, formyl, d-Gjalkyl-C^O)-, CrC4alkyl-S(0)2-NH-f CFs-CrCaalkyl-SCOVNH-, 1-pyrrolidinyl-carbonyl, 1-piperidinyl-carbonyl, 4-morpholinyl-carbonyl, 4-(CrC4alkyl)-1-piperazinyl carbonyl, 4-piperidinyl, 1-piperidinyl, l-CCi-C^lkyl-carbonylH-piperidinyl, 1f2,3,6-tetrahydro-4-pyridyl, 1-(Cr C4alkyl-carbonyl)-1,2,3,6-tetrahydro-4-pyridyl, 1-piperazinyl, 4-(CrC4alkyl)-1-piperazinyl, 4-(CrC4alkyl-carbonyl)-1 -piperazinyl, 4-(C3-C5cycloalkyl-carbonyl)-1-piperazinyl, 4-(C1-C4alkoxy-carbonyl)-1 -piperazinyl, 4-(CrC4alkyl-S02)-1 -piperazinyl, 1,4-diazacyclohept-1 -yl, 4-(CrC4alkyl-carbonyl)-1,4-diazacyclohept-1 -yl, 2-oxo-1 -Ryrrolidinyl,3>3-di-(CrC4alkyl)-2-oxo-1-pyrrolidinyl; (P) R3-CrC4alkyl, wherein R3 represents hydrogen, hydroxyl, carboxy, Ci-C4alkyl-N(CrC4alky!)-, CrC4alkyl-NH-, 1-pyrrolidinyl, 1-piperidyl, 4-(CrC4alkyl)-1-piperazinyl carbonyl, 2f4-dioxa-5l5-(di-CrC4alkyl)-oxa2olJdin-3-yl> RiRsN-CKO)-, wherein R4 and R5 independently of each other represent hydrogen or CrC4alkyl; or (y) ReR7N-C(0)-, wherein R6 and R7 independently of each other represent hydrogen, CrC4alkyl, C5-C7cycloalkyl-CrC4aIkyl, CF3-CrC3alkyl or pyridyl-CrC4alkyl; (p) pyridyl, which is unsubstituted or mono- or disubstituted by halogen or CrC4aIkyI which is di- or trisubstituted by halogen; (q) pyrimidyl; (r) indolyl, which is monosubstituted by CrC4alkyl-C(0)-NH-CrC4alkyl; (s) Z-CCrC^lkyO-benzothiazolyl; (t) a radical of subformula la wherein R& is hydrogen, R9 is hydrogen, and m is 2 or 3; or (u) a radical of subformula lb wherein Rio is hydrogen, Rn is hydrogen, and n is 2 or 3; R2 represents Ci-Csalkyl, which is unsubstituted or substituted by Cs-Cycycloalkyl, which is unsubstituted or disubstituted by halogen, or phenyl, which is mono- or disubstituted by halogen; under the proviso that R2 does not represent 1,1-dimethylethyl if Y is O and R, is selected from 3-pyridyl, 4-pyridyl, 5-chlon>3-pyridyl, 6-chloro-3-pyridyl, 2-chloro-4-pyridyl> 2-trifluoromethyl-4-pyridyl, 2-difluoromethyl-4-pyridylf 4-acetyH-piperazinyl-phenyl, 4-methyl-1-piperazinyl-methyl-phenylf and under the proviso that R2 does not represent 1,1-dimethylethyl, if Y is S and R1 is 4-pyridyl; or Y is CH2 or -CH=CH-, p is 1 or 2, -Ri represents (e) thienyl, thiazolyl, 1-piperidinyl-carbonyl, or (f) phenyl which is unsubstituted or mono- or disubstituted by (i) CrC4alkoxy, H2N-C(0)-, 4-(CrC4alkyl-carbonyl)-1-piperazinyl, 2-oxo-1-pyrrolidinyl, or halogen; (ii) Ri2-0-C(0)-, wherein Ri2is hydrogen or CrC4alkylf or (iji) Ri3NH-f wherein Ri3 represents hydrogen or a radical Ri4-CrC4alkyl-Z-, wherein Z is CO or S02 and R14 denotes hydrogen, trifluoromethyl or CrC4alkoxy, (Iv) Ri5-C1-C4alkyl, wherein R15 denotes hydrogen, hydroxy, lower alkoxy, 1-pyrrolidinyl, 2-oxo-1-pyrroIidinyl, imidazolidin-2,5-dion-1-yl, 5,5-dimethyl-oxazolidin-2,4-dion-3-yl or CrC4alkyl-N(R16)-, wherein R10 represents hydrogen or CrC4alkyl; and R2 represents (a) CrCyalkyl, which is unsubstituted or substituted by C2-C3alkenylf indanyl, C3-C7cycloalkyl which is unsubstituted or disubstituted by halogen or Ci-C4alkylv C3-C/cycloalkenyl, phenyl, which is unsubstituted or moro- or disubstituted by halogen or by Ci-C4alkyl; (b) QrCycycloalkyl; or (c) d*-C4alkylcarbonyI; under the proviso that, if Y is CH2, Ri represents 4-chlorophenyl and p is 1, R2 does not denote 1,1-dimethylethyI, 1-methylethyl, cyclopropyl, cyclohexyl, 2-methyl-propyl or 2-ethyl-propyl; under the proviso that R2 does not represent 1,1-dimethylethyl, if p is 1, Y is CH2 and R^ represents thienyl, phenyl, methoxyphenyl, propoxyphenyl, 4-fluorophenyl, 4-methylphenyl, 4-ethylphenyl, 4-butylphenyl, hydroxymethylphenyl, 4-(5,5-dimethyl-oxazolidin-2,4-dion-3-yl-methyl)-phenyl, 4-(methylsulfonylamino)-phenyl, 4-(n-butyl-sulfonylamino)-phenyl, 4-(ethylsulfonylamino)-phenyl,4-(n-propylsulfonylamino)-phenylf 4-(iso-propylsulfonylamino)-phenyl, 4-aminophenyl, 4-(acetylamino)-phenyl, 4-(butanoylamino)-phenyl or 4-(diethylaminomethyl)-phenyl; and under the proviso that that R2 does not represent 1-methylethyl, if p is 1, Y is CH2 and Ri represents phenyl which is unsubstituted or substituted by 4-acetyI-1-piperazinyl; or Y is CH2, p is 1, Ri represents (a) 1,2,3,6-tetrahydropyrid-1-yl, 4-(CrC4alkyl)-1,2f3,6-tetrahydropyrid-1-yl, 4,5-di(Cr C4a!kyl)-1,2,3,6-tetrahydropyrid-1-yl, 5-chloro-1,2,3f6-tetrahydropyrid-1-yl,4-phenyl-1,2,3,6-tetrahydropyrid-1-yl, Inmidazolyl, 2-(CrC4alkyl)-1-imidazolylf 4,5-dihalo-1-imidazolyl, imidazolidin-2,5 imidazolidin-2,5-dion-1 -yl, 3-trifluoromethyl-3,4-pyrrolin-1 -yl, 1 -pyrrolidinyl, 3-CrC4alkyl-1 -pyrrolidinyl, 3f3-di-(CrC4alkyl)-1-py.rrolidinyl, 3-CrC4alkoxy-1 -pyrrolidinyl, 3-C1-C4alkyl-2-oxo-1-pyrrolidinyl, 3,3"di-(C1-C4alkyl)-2-oxo-1-pyrrolidinyl, 3-halo-1 -pyrrolidinyl, 3,3-di-halo-1-pyrrolidinyl, 3,3-di-ha!o-1-piperidinyl, 1H-1,2,3-triazoM-yl, 2H-1,2f3-triazol-2-yl, 1H-1,2f4-triazol-1-yl, 3-nitro-1H-1,2,4-triazoi-1-yl, 2-phenyM-imidazolyl, 2H-tetrazol-2-yl, 1H-tetrazol-1 -yl, benzo[b]imidazol-1 -yl, 3-(1 -(C1-C4alkyl-S02)-4-piperidinyl)-2l3-dihydro-2-oxo-benzo[b]imidazol-1-yl, 3-(1-CrC4alkylcarbonyl-4-piperidinyl)-2,3-dihydro-2»oxo-benzo[b]imidazoM-yl, 1-indolyI, 6-halo-1-indolyl, 1,3-dihydro-2-isoindolyl, 2,3-dihydro-1-indolyl, 2,3-dihydro-2-oxo-benzo[b]thiazol-3yl, 6f7-di-(CrC4alkoxy)-1,2,3,4-tetrahydroquinnolin, 6-CrC4alkoxy-1,2,3,4-tetrahydroisoquinnolin, 7-CrC4alkoxy-1,2,3,4-tetrahvdroisoquinnolin; (b) a radical of substructure Ic which is bound to the molecule via the nitrogen atom, wherein X is -©-, -(CH2)S-CR17RIB- or -NR18, wherein s is 0 or 1, R17 and R18 are independently selected from hydrogen, halogen, hydroxy, d- C4alkyl, phenyl-CrC4alkyl-carbonyl, carbamoyl, N-phenyl-carbamoyl, cyano, 4-pyridyl, 1- piperidinyl and phenyl which is unsubstituted or monosubstituted by halogen or Cr C4alkoxy, or, if X is CR17R1B) R17 and R18 and together form an oxo group or a group HO- C(0)-CH=, and R23, R24, R25 and R26 are independently selected from hydrogen and CrC4alkyl; (c) a radical of substructure Id which is bound to the molecule via the nitrogen atom, wherein k is 0 or 1, A is CH2 or a bond, B is CH2 or carbonyl, D is CH2 or carbonyl, E is CH2 or NR^, G is CH2 or a bond, Q is CH2 or carbonyl, T is CH2 or NR29, R19 represents hydrogen, CrC4alkyl, phenyl-d-C4alkyl, CrC4alkylcarbonyl or CrC4alkyl-S02-, R^ is hydrogen and R29 is phenyl; (d) a radical of substructure le which is bound to the molecule via the nitrogen atom, wherein R27 is CrC4alkyl or CrC4alkylcarbonyl and R28 is hydrogen, Ci-C4alkoxy or halogen; or (e) NR20R2i, wherein R20 and R2? are independently selected from hydrogen, CrC4alkyI, C3-C7cycloalkyl which is unsubstituted or monosubstituted by hydroxy; and phenyl which is unsubstituted or monosubstituted by 1,2,3-thiadiazol-4-yl, under the proviso that not both R20 and R21 can represent hydrogen at the same time; and R2 denotes Ci-C8alkyl, which is unsubstituted or substituted by C3-C7cycloalkyi which is unsubstituted or disubstituted by halogen; phenyl, which is mono- or disubstituted by halogen; . under the proviso that R2 does not represent 1,1-dimethyIethyl, if (a) Ri is benzo[b]imidazol-1-yl, 1-imidazolyl, 4f5-dichloro-1-imidazolyl, 2-(CrC4alkyl)-1-imidazolyl, imidazolidin-2,5-dion-1-yl, 5,5-dimethyl-oxazoIidin-2,4-dion-3-yl, 1H-1,2,3-triazol-1-yl, 2H-1,2,3-triazol-2-yl, S-nitro-IH-l^-triazoM-yl, 2H-tetrazol-2-yl or 1H-tetrazol-1-yl, or if Rt is a radical of substructure lc, R23 to R26 are hydrogen, X is NR18 and RIB is hydrogen, methyl, ethyl, acetyl, 4-pyridyi, 1-piperidinyl, phenyl, methoxyphenyl, ethoxyphenyl, fluorophenyl or chlorophenyl; (b) R, is a radical of substructure !c, R2S to R23 aro hydrogen, X Is -(r-H2}s CRi7R*B-i * is 0, and R17 and Ri8 are selected from hydroxyl and phenyl which is monosubstituted by chloro or Ri7 and R18 are selected from hydrogen, methoxyphenyl and N-phenyl-carbarnoyl; or (c) Ri is a radical of substructure Id, k is 1, A is a bond, E is NR^, R22 is hydrogen, G, Q and T are CH2, B and D are carbonyl and R19 is methyl, n-propyl or iso-butyl; under the proviso that R2 does not represent 2-methylpropyl, if R^ is a radical of substructure Id, k is 1, A is a bond, E is NR22, R22 is hydrogen, G, Q and T are CH2, B and D are carbonyl and R19 is methyl, or if Ri is a radical of substructure lc, R23 to R26 are hydrogen, X is "(CH2)S-CR17R18-, s is 0, and Ri7 and R18 are selected from hydrogen and phenyl which is monosubstituted by methoxy; and under the proviso that R2 does not represent 1-methyiethyl, if R1 is a radical of substructure lc, R23 to R26 are hydrogen, X is NRi8 and R18 is methoxyphenyl or ethoxyphenyl, or X is CRi7R18 and R17 and R?8 are selected from hydrogen and methoxyphenyl; or a tautomer thereof, or a salt of such pyrrolo pyrimidine or its tautomer. ♦3. A pyrrolo pyrimidine of formula I according to claim 1 or 2, or an N-oxide or a tautomer thereof, or a pharmaceutical^ acceptable salt of such a compound, for use in a method for the treatment of the human or animal body. 4. Use of a pyrrolo pyrimidine of formula I according to claim 1 or 2, or an N-oxide or a tautomer thereof, or a pharmaceutically acceptable salt of such a compound, for the preparation of a pharmaceutical product for the treatment of neuropathic pain. 5. A method for the treatment of neuropathic pain, which comprises administering a pyrrolo pyrimidine of formula I according to claim 1 or 2, or a N-oxide or a tautomer thereof, or a pharmaceutically acceptable salt thereof, its N-oxide or its tautomer, in a quantity effective against said disease, to a warm-blooded animal requiring such treatment. 6. A pharmaceutical preparation, comprising a pyrrolo pyrimidine of formula I according to claim t or 2, or an N-oxide or a tautomer thereof, or a pharmaceutically acceptable salt of such a compound, or a hydrate or solvate thereof, and at least one pharmaceutically acceptable carrier. 7. A process for the preparation of a pyrrolo pyrimidine of formula I wherein Y represents -(CH2)rO- or (CH2)r-S- p is 1 or 2, ris 1,2 or 3, tis1,2or3, fy represents (v) phenyl which is unsubstituted or mono-, di- or trisubstituted by (a) halogen, carboxy, alkoxy, nitro, alkyl-C(0)-NH-, cycIoaIkyl-G(0)-NH-, alkyl-C(O)-N(alkyl)-( formyl, alkyl-C(O)-, alkyl-S(0)2-NH-t CF3-alkyl-S(0)2-NH-f pyrrolidinyl carbonyl, piperidinyl carbonyl, morpholinyl carbonyl, N-alkyl piperazinyl carbonyl, piperidinyl, 1-(alkyl carbonyl) piperidinyl, 1,2,3,6-tetrahydropyridyl, alkyl carbonyl 1,2,3,6-tetrahydropyridyl, piperazinyl, alkyl piperazinyl, alkyl carbonyl piperazinyl, cycloalkyl carbonyl piperazinyl, alkoxy carbonyl piperazinyl, alkyl-S02-plperazinyl, diazacycloheptyl, alkyl carbonyl diazacycloheptyl, 2-oxo-1 -pyrrolidinyl, 3,3-di-alkyl-2- oxo-1-pyrrolidinyl; (P) fValkyl, wherein R3 represents hydrogen, hydroxy, carboxy, alkyl-N(alkyl)-, alkyl- NH-, 1-pynrolidinyl, 1-piperidyl, 4-aikyl-1-piperazinyl carbonyl, 2,4-dioxa-5,5-(di-alkyl)- oxazolidin-3-yl, R4R5N-C(0)-, wherein R4 and R5 independently of each other represent hydrogen or alkyl; or (y) ReR7N-C(0)-( wherein R6 and R7 independently of each other represent hydrogen, alkyl, cycloalkyl alkyl, CF3-alkyl or pyridyl alkyl; (w) pyridyl, which Is unsubstituted or mono-, di- or trisubstituted by halogen or alkyl which is mono-, di- or trisubstituted by halogen; (x) pyrimidyl; (y) »ndolyl, which is mono- or disubstituted by aIkyl-C(0)-NH-a!kyl;. (z) 2-(alkyl)-benzothiazolyl; (aa) a radical of subformula la wherein R8 is hydrogen, halogen or alkyl, R9 is hydrogen or alkyl, and m is 1, 2, 3 or 4; or (bb) a radical of subformula lb wherein Rio is hydrogen, halogen or alkyl, Rn is hydrogen or alkyl, and n is 1,2, 3 01 4; R2 represents alkyl, which is unsubstituted or substituted by cycloalkyl, which is unsubstituted or mono- or disubstituted by halogen, or phenyl, which is mono- or disubstituted by halogen; under the proviso that R2 does not represent 1,1-dimethylethyl if Y is O and fy is selected from 3-pyridyl, 4-pyridyl, 5-chloro-3-pyridyl, 6-chloro-3-pyridyl, 2-chloro-4-pyridyl, 2-trifIuoromethyl-4-pyridyI, 2-difluoromethyl-4-pyridyl, 4-acetyM-piperazinyl-phenyl, 4-methyl-1 -piperazinyl-methyl-phenyl, and under the proviso that R2 does not represent 1,1-dimethylethyl, if Y is S and Ri is 4-pyridyl; wherein an alcohol or a thiol of formula llv Rr(Y)p-H (II) wherein Y represents -(CH2)rO- or (CH2)rS- and t, r and R^ have the meanings as provided above for a compound of formula I, is alkylated with a pyrrolp pyrimidine of formula Si I wherein R2 has the meaning as provided above for a compound of formula I and Hal denotes halo, preferably bromo, wherein the starting compounds of formula II and III may also be present with functional groups in protected form, if necessary, and/or in the form of salts, provided a salt-forming group is present and the reaction in salt form is possible; wherein any protecting groups in a protected derivative of a compound of the formula I are removed; and, if so desired, an obtainable compound of formula I is converted into another compound of formula I or a N-oxide thereof, a free compound of formula I is converted into a salt, an obtainable salt of a compound of formula I is converted into the free compound or another salt, and/or a mixture of isomeric compounds of formula I is separated into the individual isomers.

Documents:

1800-chenp-2005-abstract.pdf

1800-chenp-2005-claims.pdf

1800-chenp-2005-correspondnece-others.pdf

1800-chenp-2005-correspondnece-po.pdf

1800-chenp-2005-description(complete).pdf

1800-chenp-2005-form 1.pdf

1800-chenp-2005-form 18.pdf

1800-chenp-2005-form 3.pdf

1800-chenp-2005-form 5.pdf

1800-chenp-2005-pct.pdf