Title of Invention

METHOD OF PRODUCING A HIGH MANNOSE GLUCOCEREBROSIDASE (hmGCB) AND THE HIGH MANNOSE GLUCOCEREBROSIDASE (hmGCB) THEREOF

Abstract

The invention features a method of producing a high mannose glucocerebrosidase (hmGCB) which includes: providing a cell which is capable of expressing glucocerebrosidase (GCB), and allowing production of GCB having a precursor oligosaccharide under conditions which prevent the removal of at least one mannose residue distal to the pentasaccharide core of the precursor oligosaccharide of GCB, to thereby produce an hmGCB preparation. Preferably, the condition which prevents the removal of at least one mannose residue distal to the pentasaccharide core is inhibition of a class 1 processing mannosidase and/or a class 2 processing manosidase. The invention also features an hmGCB preparation and methods of using an hmGCB preparation.

Full Text	N/A

Documents:

in-pct-2002-00439-mum-abstract(amended)-(5-1-2009).pdf

in-pct-2002-00439-mum-abstract(granted)-(27-2-2009).pdf

in-pct-2002-00439-mum-assignment(10-4-2002).pdf

IN-PCT-2002-00439-MUM-CANCELLED PAGES(19-1-2009).pdf

in-pct-2002-00439-mum-cancelled pages(5-1-2009).pdf

in-pct-2002-00439-mum-claims(10-4-2002).pdf

IN-PCT-2002-00439-MUM-CLAIMS(AMENDED)-(19-1-2009).pdf

in-pct-2002-00439-mum-claims(granted)-(27-2-2009).pdf

IN-PCT-2002-00439-MUM-CORRESPONDENCE(17-12-2008).pdf

IN-PCT-2002-00439-MUM-CORRESPONDENCE(19-6-2009).pdf

in-pct-2002-00439-mum-correspondence(5-1-2009).pdf

in-pct-2002-00439-mum-correspondence(ipo)-(25-2-2009).pdf

in-pct-2002-00439-mum-description(complete)-(10-4-2002).pdf

in-pct-2002-00439-mum-description(granted)-(27-2-2009).pdf

in-pct-2002-00439-mum-drawing(10-4-2002).pdf

in-pct-2002-00439-mum-drawing(amended)-(5-1-2009).pdf

in-pct-2002-00439-mum-drawing(granted)-(27-2-2009).pdf

in-pct-2002-00439-mum-form 1(10-4-2002).pdf

IN-PCT-2002-00439-MUM-FORM 1(17-12-2008).pdf

IN-PCT-2002-00439-MUM-FORM 1(5-1-2009).pdf

in-pct-2002-00439-mum-form 13(17-12-2008)-.pdf

in-pct-2002-00439-mum-form 13(17-12-2008).pdf

in-pct-2002-00439-mum-form 18(16-8-2005).pdf

in-pct-2002-00439-mum-form 2(complete)-(10-4-2002).pdf

in-pct-2002-00439-mum-form 2(granted)-(27-2-2009).pdf

in-pct-2002-00439-mum-form 2(title page)-(10-4-2002).pdf

IN-PCT-2002-00439-MUM-FORM 2(TITLE PAGE)-(17-12-2008).pdf

in-pct-2002-00439-mum-form 2(title page)-(granted)-(27-2-2009).pdf

in-pct-2002-00439-mum-form 3(10-4-2002).pdf

in-pct-2002-00439-mum-form 3(5-1-2009).pdf

in-pct-2002-00439-mum-form 5(10-4-2002).pdf

in-pct-2002-00439-mum-power of authority(5-12-2002).pdf

in-pct-2002-00439-mum-specification(amended)-(17-12-2008).pdf

in-pct-2002-00439-mum-specification(amended)-(5-1-2009).pdf

in-pct-2002-00439-mum-wo international publication report(10-4-2002).pdf

IN-PCT-2002-0439-MUM-ABSTRACT(5-1-2009).pdf

IN-PCT-2002-0439-MUM-CANCELLED PAGES(5-1-2009).pdf

IN-PCT-2002-0439-MUM-CLAIMS(5-1-2009).pdf

IN-PCT-2002-0439-MUM-CLAIMS(AMENDED)-(19-1-2009).pdf

IN-PCT-2002-0439-MUM-CORRESPONDENCE(19-1-2009).pdf

IN-PCT-2002-0439-MUM-CORRESPONDENCE(20-1-2009).pdf

IN-PCT-2002-0439-MUM-CORRESPONDENCE(5-1-2009).pdf

IN-PCT-2002-0439-MUM-DESCRIPTION(COMPLETE)-(5-1-2009).pdf

IN-PCT-2002-0439-MUM-DRAWING(5-1-2009).pdf

IN-PCT-2002-0439-MUM-FORM 1(10-4-2002).pdf

IN-PCT-2002-0439-MUM-FORM 1(5-1-2009).pdf

in-pct-2002-0439-mum-form 2(5-1-2009).pdf

IN-PCT-2002-0439-MUM-FORM 2(TITLE PAGE)-(5-1-2009).pdf

IN-PCT-2002-0439-MUM-FORM 3(5-1-2009).pdf

IN-PCT-2002-0439-MUM-FORM 5(5-1-2009).pdf

IN-PCT-2002-0439-MUM-OTHER DOCUMENT(5-1-2009).pdf

IN-PCT-2002-0439-MUM-PCT-ISA-210(5-1-2009).pdf

IN-PCT-2002-0439-MUM-PETITION UNDER RULE 137(6-1-2009).pdf

IN-PCT-2002-0439-MUM-PETITION UNDER RULE 138(6-1-2009).pdf

IN-PCT-2002-0439-MUM-POWER OF AUTHORITY(5-1-2009).pdf