Title of Invention

A PROCESS FOR PREPARATION OF HERBAL FORMULATION USEFUL FOR THE TREATMENT OF DIABETES

Abstract

The invention relates to the herbal formulation of betel leaf and Tulsi for the treatment of diabetes. The formulation comprises fresh betel leaf about 2-5 g by weight and 5-6 g of tulsi (ocimum sanctum) by weight. The seeds or inflorescence part with seeds of tulsi(Ocimum sanctum) is used for herbal formulation.The betel leaf is taken afresh. The formulation is effective for the treatment of diabetes.and has no side effect at all.

Full Text

Field of the Invention The present invention relates to herbal formulation useful for the treatment of diabetes whereinbetal leaf and ocimum sanctum is used. Background of the invention Today, Diabetes Milletus has become a common disease which eats away people's health as a termite eating away wood and making it hollow from within, thus engulfing man into death's mouth. Thus, through this presentation, we bring about such an idea, a dosage that can easily root out diabetes. Thus, the following presentation deals with the know-how of diabetes, so as to gain deep knowledge of its cause, effect and finally grasping a cure to it. The end of the presentation makes an implied appeal to the CSIR foundation to develop a drug including the mixture of presented product under correct conditions. But here we present an experimented dosage before you. The need of the hour transfers this Ayurvedic Product to an Allopathic tablet / Syrup. Hope that our dosage shall be converted to a drug to help the general mass skip out this dreadful disease "DIABETES". The word Ayurveda means the ' Science of Life' and it stands in clear contrast to the term 'Science of medicine*. Ayurved concerns itself with life and its dynamic force, their regulation and control. It treats the 'Man' and not the disease. It is the method of treatment based on the principles controlling life, which counts in Ayurved, and not only to subdue external manifestations of so called disease. Health Therapy forms the very basis of treatment in all the major indigenous systems of medicines that have been in the vogue in our country from time immemorial. In Ayurved the treatment of all pathological conditions has but one aim and line of therapeutic procedure viz to bring back to normal the working of the governing factors. DIABETES MELLITUS Diabetes Mellitus is a clinical syndrome characterized by hyperglycaenua due to a absolute or relative deficiency of insulin. Lack of insulin affects the metabolism of carbohydrate, protein and fat and causes a significant disturbance of water and electrolyte homeostasis. Death may result from standing metabolic derangement frequently associated with permanent and irreversible functional and structural changes in the cells of the body, with those of the vascular system being particularly susceptible these changes lead to the well- defined clinical entities, the so-called 'complications of diabetes' which characterically affect the eye, the kidney and the nervous system. Classification of Diabetes Mellitus Primary • Type 1 or Insulin Dependent Diabetes Mellitus.(IDDM) • Type 2 or non-lnsuiin Dependent Diabetes Mellitus.(IDDM) Other specific types of diabetes • Pancreatic disease • Excess endogenous productional of hormonal antagonists to insulin • Medication • Associated with genetic syndromes. Gestational Epidemiology Diabetes is world wide in distribution and the incidence of both types is rising. Prevalence of varies considerably in different parts of the wore. This is probably due to the differences in genetic environmental factors. Aetiology Type 1 diabetes 1. Genetics. Genetic factor accounts for about 1/3 of the susceptibility to type 1 diabetes the inheritance of which is polygenic. 2. Environmental factors i. Viruses - Virus particles are known to cause cytopathic and auto-immune damage to - cells, e.g. - Mumps virus, retro viruses , rubella ii. Diet - Bovine Serum albumin a major constituent of cow's milk has been implicated in triggering type 1 diabetes BSA may cross the neonatal and raise antibodies causing damage to cell components various nitrosaines and coffee have be proposed as potentially diabetegenic factors. iii. Stress -Stress may progress the development type 1 diabetes by stimulating the secretion of counter regulatory hormones and possibly by modulating immune activity. 3. Immunological factors. 4. Pancreatic pathology - Insulitus. Type 2 diabetes commonly occurs in subjects who are obese and insulin resistant but these 2 factors alone are insufficient to cause diabetes unless accompanied by impaired11 beta cell function. 1. Genetics - Genetic factors are more important in the aetiology of type 2 than type 1 diabetes 2. Environmental factors i. Life style- overeating, obesity and under activity are associated with development of type 2 diabetes ii. Malnutrition in utero 3. Age- It is usually associated to above 50 yrs. Aged people 4. Pregnancy The hyperglcaeia of diabetes develops because of an absolute (type 1 diabetes) or a relative (type 2 diabetes) deficiency of insulin, resulting in decreased anabolic and increased catabolic effects. In above type 1 & type 2 diabetes, Insulin's actions are also impaired by insensitiviry of target tissues. Actions of Insulin Decrease (Anti-catabolic Effect) Gluconeogenesis Glycogenolysis Increase (Anabolic Effects) Carbohydrate Metabolism Glucose transport (Muscle, Adipose tissue) Glucose phosphorylation Glycogenesis Glycolysis Pyruvate dehydrogenase activity Pentose phosphate shunt Lipolysis Lipoprotein lipase (muscle) Kitogenesis fatty acid oxidation (liver) Liquid Metabolism Triglyceride synthesis Fatty acid synthesis (liver) Lipoprotein lipase activity (adipose tissue) Protein Metabolism Protein degradation Amino acid Transport Protein Synthesis Electrolytes Cellular potassium uptake Scope of Diabetes Diabetes has now struck miillions and millions of mankind of the world with each diabetic acting due to lack of innovative effective drug. Oral Hypoglcaeic Drugs Sulfonvlureas BIGUANIDES MISCELLANEOUS Tolbutamide Phenformin Acarbose Chloropropamide Metformin Guargum Acetohexamide Pioghtazene Tolazamide Ripoglitazene Gilbeclamide Glipizide Gliclaade These dregs tower blood glucose levels and are effective orally. The chief drawback of insulin is - it must be given by injection. Orally active drugs have always been searched. The early Sulfonamides tested in 1940'sprodu Adverse effects of these drugs 1. Hypoglycaemia 2. Non- specific side effects - Nausea, Vomiting, flatulence, diarrhoea or constipation, headache, paraesthesias and weight gain. 3. Hvpcrsenstivity - Rashes, photosentivity, purpura, transient leukopenia. 4. Lactic Acitosis caused by biguanides 5. Vitamin Bn deficiency caused by biguanides. Chropropamide in addition causes chdestatic jaundice, dilutional hyponatremia, intolerance to alcohol. Tolbutamide reduces iodide uptake by thyroid. Safety Sulfonylureas during pregnancy is not established. In addition to general restrictions for use of oral . Hypoglycaemics, biguanides are contradictated in Hypotensive states, cardiovascular, respiratory, hepatic and renal disease and in alcoholic because of increased risk of lactic acidosis. New Drugs that were presented in arks but were withdrawn of their similar side- effect. 1. Lyspro Insulin 2. Antihyperglycaeic drugs' Thiazolidinediones1 { effect -Haematological toxicity} 3. Troglitazone { effect - hepato- toxicity} Objects of the invention On coming to line to all such side-effects of such drugs, presently been used up in the marked to over come diabetes. It has become a pious duty of citizens/ doctors/ professors to introduce a drug that has no side-effect and could effectively rule diabetes. For such a drug, we have now clinched up to Herbal Ayurveda through our Invention of Diabetes over-ruler, a Herbal Product1. If a diabetic patient chews a betel leaf whose latin name is' Asplenium Falentum' called ' Pan' a common Hindi language with its " DanthaT referring to " Pan leaf bark or stem1 and 5 g of Basil (Tulsi) plant i.e. 'Ocimum Sanctum' early in the morning before taking anything else, is perfectly cured of diabetes. This course is to be taken 8 days continuously. The results are really amazing. This course can be repeated after regular intervals. According to the present invention the herbal formulation useful for the treatment of diabetes comprising of green betal leaf and Tulsi (ocimum sanctum) in the range of 1:2 to 1:1 to obtain the said composition. In an embodiment of the present invention^ process for preparation of herbal formulation which comprises a. Mixing fresh green betel leaf and Tulsi in the range of 1:2 to 1:1. b. Grinding the mixture as in form of paste at temperature of 25-30°C. In other embodiment of the invention.the ingredients Tulsi is selected from dry seeds or inflorescence part and which is either fresh or dry. In yet another embodiment of the invention,the ingredients betal leaf is fresh and green leaf of plant Aspleniumfalentum Summary of the invention The studies have been undertaken for development of herbal formulation for the treatment of diabetes. The herbal formulation comprising of betel leaf and tulsi seeds or flowering parts of tulsi has been proved effective for the treatment of diabetes.. The dosage of this composition cures diabetes if taken once daily in empty stomach for 8-10 days and may be repeated at regular interval. The formulation of the present invention is described herein below with referance to the following examples which are illustrative and should not be construed to limit the scope of the present invention in any manner whatsoever. Example 1 Composition (for each dosage) Pan leaf {Asplenium Falentum} 2-5 g Tulsi {Ocimum Sanctum } 5 g Therapeutic Value Ocimum Sanctum - Antipyretic, Amidiabetic, Diaphoretic and Expectorant, A domestic remedy for diabetes, croup, catarrh, bronchitis and chronic cough. Asplenium Falentum- A domesrtic remedy to cure diabetes, jaundice, malaria etc. Presence Ocimum Sanctum - it is found commonly on the Northern Plains of India Asplenium Falentum - It is found at Madras Presidency, Srilanka and Eastern Himalayas. Dosage 1 pan leaf along with 5 g of Tulsi, a day for people aged between 30-60 years. Advantage 1. The drug has no side-effect and could effectively cure diabetes. We claim: 1. A herbal formulation useful for the treatment of diabetes comprising of fresh green betal leaf and ocimum sanctum comprising of green betal leaf and Tulsi (ocimum sanctum) in the range of 1:2 to 1:1 to obtain the said composition. 2. A process for prepation of herbal formulation which comprises a. Mixing fresh green betal leaf and Tulsi in the range of 1:2 to 1:1. b. Grinding the mixture as in form of paste at temperature of 25-30°C. 3. A process for preparation of herbal formulation as claimed in claim 2 the ingredients tulsi(ocimum sanctum)is selected from dry seeds or inflorescence part and which is either fresh or dry. 4. A herbal formulation useful for the treatment of diabetes substantially as herein described with reference to example 1.

Documents:

969-DEL-2002-Abstract-(03-12-2008).pdf

969-del-2002-abstract.pdf

969-DEL-2002-Claims-(03-12-2008).pdf

969-del-2002-claims.pdf

969-DEL-2002-Correspondence-Others-(03-12-2008).pdf

969-del-2002-correspondence-others.pdf

969-del-2002-correspondence-po.pdf

969-del-2002-description (complete).pdf

969-del-2002-form-1.pdf

969-del-2002-form-18.pdf

969-del-2002-form-2.pdf

969-del-2002-form-3.pdf

969-del-2002-form-4.pdf

969-del-2002-form-5.pdf