Title of Invention

SUBSTITUTED 4-PHENYLTETRAHYDROISOQUINOLINES AND METHOD FOR THE PRODUCTION THEREOF

Abstract

The invention relates to compounds of formula I wherein Rl to R9 have the designations cited in the patent claims. Medicaments containing this type of compound can be used in the prevention or treatment of various illnesses. Said compounds can be used, inter alia, for renal diseases such as acute or chronic kidney failure, for disturbances of the biliary function, for respiratory disturbances such as snoring or sleep apnoea, or for apoplexy.

Full Text

Description Substituted 4-phenyltetrahydroisoquinolines, method for production thereof, the use of the same as medicaments, and medicament containng such compounds The invention relates to compounds of the substituted 4-phenyltetrahydroisoquinoline type. Medicaments which comprise compounds of this type are useful in the prevention or treatment of various disorders. For instance, the compounds can be used, among other uses, in the event of renal disorders such as acute or chronic renal failure, in the event of disorders of biliary function, in the event of respiratory disorders such as snoring or sleep apneas or in the event of stroke. The invention relates to compounds of the formula I where: R1.R2, R3andR4 are each independently H, F, CI, Br, I, CN, NO2, OH, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated, cycloalkyl having 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated, O-alkyl having 1,2,3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated, Ok-(CH2)i-phenyl, heteroaryl having 1, 2, 3 or 4 nitrogen atoms or 1 oxygen atom or 1 sulfur atom, Oh-SOj-R10, NR14R15, CONR16R17, COOR18 or OCOR18; k isOorl; I isO, 1,2, 3 or 4; h is 0 or 1; j is 0, 1 or 2; R10 is alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated, OH, O-alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated or NR11R12; R11 and R12 are each independently hydrogen, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated and one or more CH2 groups may be replaced byO, NR13, CO or CS, R13 is H or alkyl having 1,2,3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated, or R11 andR12 together with the nitrogen atom which bonds them together may form a 5- or 6-membered ring; R14andR15 are each independently H, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated and one or more CH2 groups may be replaced by O, CO, CS or NR19, or R14andR15 together with the nitrogen atom which bonds them together may form a 5- or 6-membered ring; R16andR17 are each independently H, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated and one or more CH2 groups may be replaced by O, CO, CS or NR19, or R16andR17 together with the nitrogen atom which bonds them together may form a 5- or 6-membered ring; R19 is H or alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated; R18 is H or alkyl having 1,2,3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated; R5 is H, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated, cycloalkyl having 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated, COR20 or SO2R2O; R20 is H or alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated; R6 is H, OH, F, CI, Br, alkyl having 1,2,3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated, cycloalkyl having 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated, O-alkyl having 1,2,3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated, or O-acyl having 1,2,3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated; R7, R8 and R9 are each independently H, F, CI, Br, I, OH, alkyl having 1,2,3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated, cycloalkyl having 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated, O-alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated, Ov- SOw-R47, COR47, COOR60, NR51R52 or a -L-G group; v is 0 or 1; w is 2 or 3; R47 is H, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated or NR48R49; R48 and R49 are each independently H, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated and one or more CH2 groups may be replaced by O, CO, CS or NR50, R50 is H or alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms of which some or all may be fluorinated; or R48 and R49 together with the nitrogen atom which bonds them together form a 5, 6, 7 or 8-membered ring; R60 is H, alkyl having 1,2,3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated; R51 and R52 are each independently H, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated, acyl having 1,2,3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated and one or more CH2 groups may be replaced by O or NR53, R53 is H or alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms of which some or all may be fluorinated; or R51 and R52 together with the nitrogen atom which bonds them together form a 5, 6, 7 or 8-membered ring; L is -CH2-, -0-, -NR30-, -OCO-, -NR30CO-, -NR30CS-, -NR30SO2-, -CONR30-, -COO-, -CSNR30-, -SO2NR3O-, -NR30CONR31-, - NR30COO-, -NR30CSNR31- or -NR30SO2NR31-; R30 and R31 are each independently H, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated or cycloalkyl having 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated; G is a Ca(OR32)xH2a+1-x group where one or more CH2 groups may be replaced by O or NR33, Cb(OR32)yH2b-1-y where one or more CH2 groups may be replaced by O or NR33, CcH2c+1 where two or more CH2 groups are replaced by O or NR33, -(CH2)z-COOR34, -(CH2)2 -SO3R34, -(CH2)Z -N+R35R36R37 where one or more hydrogen atoms of the -(CH2)z units may be replaced by OR32 groups, -CR38R39-COOR40 or -CR38R39NR41R42, a is 2, 3,4, 5,6, 7 or 8; x is 2, 3,4, 5,6, 7 or 8; R32 is H, alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms of which some or all may be fluorinated or acyl having 1, 2, 3, 4, 5 or 6 carbon atoms of which some or all may be fluorinated; R33 is H or alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms of which some or all may be fluorinated; b is 3, 4, 5, 6 or 7; y is 2, 3,4, 5, 6 or 7; c is 3, 4, 5, 6, 7 or 8; z is 0, 1,2, 3 or 4; R34, R35, R36 and R37 are each independently H or alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms of which some or all may be fluorinated; R38 is -(CH2)n -Y; n is 0, 1,2, 3 or 4; Y is H, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated and one or more CH2 groups may be replaced by O, S or NR43, or is -COOR44, -CONR45R46, -NHC(NH)NH2, phenyl or heteroaryl, and the phenyl and heteroaryl radicals may be substituted by up to three substituents selected from the group of CH3, CF3, OH, OCH3 and NH2; R43, R44, R45 and R46 are each independently H or alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms of which some or all may befluorinated; R39 is H or alkyl having 1,2,3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated; R40 is H or alkyl having 1,2,3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated; R41 and R42 are each independently H, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated or acyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated; in which at least one of the R7, R8 or R9 radicals has to be defined by the -L-G group, and also its pharmaceutical^ acceptable salts and trifluoroacetates. Preference is given to compounds of the formula I where R1,R2, R3andR4, are each independently H, F, CI, Br, I, CN, NO2, OH, alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated, cycloalkyl having 3, 4, 5 or 6 carbon atoms of which some or all may be fluorinated, O-alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated, O-phenyl, SO2R10, NR14R15, CONR16R17, COOR18 or OCOR18; R10 is alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated, OH or NR11R12; R11 andR12 are each independently hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated, or acyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated, or R11 and R12 together with the nitrogen atom which bonds them together form a 5- or 6-membered ring, from the group of 1-pyrrolyl, 1-piperidinyl, 1-piperazinyl, 1-N-methylpiperazinyl and 4-morpholinyl; R14andR15 are each independently H, alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated or acyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated, or R14andR15 together with the nitrogen atom which bonds them together form a 5- or 6-membered ring, from the group of 1-pyrrolyl, 1-piperidinyl, 1-piperazinyl, 1-N-methylpiperazinyl and 4-morpholinyl; R16andR17 are each independently H or alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated, or. R16andR17 together with the nitrogen atom which bonds them together form a 5- or 6-membered ring, from the group of 1-pyrrolyl, 1-piperidinyl, 1-piperazinyl, 1-N-methylpiperazinyl and 4-morpholinyl; R18 is H or alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated; R5 is H, alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated, or cycloalkyl having 3, 4, 5 or 6 carbon atoms of which some or all may be fluorinated; R6 is H, OH, F, CI, Br, alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated, cycloalkyl having 3, 4, 5 or 6 carbon atoms of which some or all may be fluorinated, O-alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated, or O-acyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated; 7, R8 and R9 are each independently H, F, CI, Br, I, OH, alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated, cycloalkyl having 3, 4, 5 or 6 carbon atoms of which some or all may be fluorinated, O-alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated, Ov-SOw-R47, COR47, COOR60, NR51R52 or a -L-G group; v isOorl; w is 2 or 3; R47 is H, alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated, or NR48R49; R48 and R49 are each independently H, alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated, acyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated, or R48 and R49 together with the nitrogen atom which bonds them together form a 5- or 6-membered ring, from the group of 1-pyrrolyl, 1-piperidinyl, 1-piperazinyl, 1-N-methylpiperazinyI and 4-morpholinyl; R60 is H, alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated; R51 and R52 are each independently H, alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated, acyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated, or R51 and R52 together with the nitrogen atom which bonds them together form a 5- or 6-membered ring, from the group of 1-pyrrolyl, 1-piperidinyl, 1-piperazinyl, 1-N-methylpiperazinyl and 4-morpholinyl; L is -CH2-, -0-, -NR30-, -OCO-, -NR30CO-, -NR30CS-, -NR30SO2-, -CONR30-, -COO-, -CSNR30-, -SO2NR30-, -NR30CONR31-, -NR30COO-, -NR30CSNR31- or -NR30SO2NR31-; where R30 and R31 are each independently H, alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated or cycloalkyl having 3, 4, 5 or 6 carbon atoms of which some or all may be fluorinated; G is a Ca(OR32)xH2a+1-x group where one or more CH2 groups may be replaced by O or NR33, Cb(OR32)yH2b_1_y where one or more CH2 groups may be replaced by O or NR33, CcH2c+1 where two or more CH2 groups are replaced by O or NR33, -(CH2)z-COOR34, -(CH2)Z-SO3R34, -(CH2)Z-N+R35R36R37 where one or more hydrogen atoms of the -(CH2)Z units may be replaced by OR32 groups, -CR38R39-COOR40 or -CR38R39NR41R42; a is 2, 3,4, 5,6, 7 or 8; x is 2, 3,4, 5,6, 7 or 8; R32 is H, alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated or acyl having 1,2,3 or 4 carbon atoms of which some or all may be fluorinated; R33 is H or alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated; b is 3, 4, 5, 6 or 7; y is 2, 3, 4, 5, 6 or 7; c is 3, 4, 5, 6, 7 or 8; z is 0, 1,2, 3 or 4; R34, R35, R36 and R37 are each independently H or aikyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated; R38 is -(CH2)n -Y; n isO, 1, 2, 3 or 4; Y is H, alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated and one or more CH2 groups may be replaced by O, S or NR43, or is COOR44, CONR45R46, NHC(NH)NH2, phenyl or heteroaryl, and the phenyl and heteroaryl radicals may be substituted by up to three substituents selected from the group of CH3, CF3, OH, OCH3 and NH2; R43, R44, R45 and R46 are each independently H or alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated; R39 is H or alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated; R40 is H or alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated; R41 and R42 are each independently H, alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated, or acyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated; in .which at least one of the R7, R8 or R9 radicals has to be defined by the -L-G group, and also its pharmaceutically acceptable salts and trifluoroacetates. Particular preference is given to compounds of the formula I where where: R1, R2, R3andR4, are each independently H, F, CI, Br, CN, NO2, OH, CH3, CH2CH3, CF3, CH2CF3, OCH3, OCH2CH3, OCF3, OCH2CF3, SO2R10, NR14R15, CONR16R17, COOR18 or OCOR18, R10 is CH3, CH2CH3, CF3, CH2CF3, OH, NR11R12, R11 andR12 are each independently H, CH3, CH2CH3, CF3, CH2CF3, COCH3, COCH2CH3, COCF3 or COCH2CF3, or R11 andR12 together with the nitrogen atom which bonds them together form a 5- or 6-membered ring from the group of 1-pyrrolyl, 1-piperidinyl, 1-piperazinyl, 1-N-methylpiperazinyl and 4-morpholinyl; R14andR15 are each independently H, CH3, CH2CH3, CF3, CH2CF3, COCH3, COCH2CH3, COCF3 or COCH2CF3, or R14andR15 together with the nitrogen atom which bonds them together form a 5- or 6-membered ring from the group of 1-pyrrolyl, 1-piperidinyl, 1-piperazinyl, 1-N-methylpiperazinyl and 4-morpholinyl; R16andR17 are each independently H, CH3, CH2CH3, CF3 or CH2CF3, or R16andR17 together with the nitrogen atom which bonds them together form a 5- or 6-membered ring from the group of 1-pyrrolyl, 1-piperidinyl, 1-piperazinyl, 1-N-methylpiperazinyl and 4-morpholinyl; R18 is H, CH3, CH2CH3, CF3orCH2CF3; R5 is H, CH3, CH2CH3, CF3 or CH2CF3; R6 is H, OH, CH3, CH2CH3, CF3, CH2CF3, OCH3, OCH2CH3, OCF3, OCH2CF3, OCOCH3, OCOCH2CH3, OCOCF3 orOCOCH2CF3; R7, R8 and R9 are each independently H, F, CI, Br, I, OH, CH3, CH2CH3, CF3, CH2CF3, OCH3, OCH2CH3, OCF3, OCH2CF3, S02R47, SO3R6O, COR47, COOR60, NR51R52 or a -L-G group; R47 is H, CH3, CH2CH3, CF3, CH2CF3 or NR48R49; R48 and R49 are each independently H, CH3, CH2CH3, CF3, CH2CF3, COCH3, COCH2CH3, COCF3 or COCH2CF3, or R48 and R49 together with the nitrogen atom which bonds them together form a 5- or 6-membered ring from the group of 1-pyrrolyl, 1-piperidinyl, 1-piperazinyl, 1-N-methylpiperazinyl and 4-morpholinyl; R60 is H, CH3, CH2CH3, CF3, CH2CF3; R51 and R52 are each independently H, CH3, CH2CH3, CF3, CH2CF3, COCH3, COCH2CH3, COCF3 or COCH2CF3, or R51 and R52 together with the nitrogen atom which bonds them together form a 5- or 6-membered ring from the group of 1-pyrrolyl, 1-piperidinyl, 1-piperazinyl, 1-N-methylpiperazinyl and 4-morpholinyl; L is -CH2-, -0-, -NR30-, -OCO-, -NR30CO-, -NR30CS-, -NR30SO2-, -CONR30-, -COO-, -CSNR30-, -SO2NR30-, -NR30CONR31-, -NR30COO-, -NR30CSNR31- or -NR30SO2NR31-; R30 and R31 are each independently H, CH3, CH2CH3, CF3 or CH2CF3; G is a Ca(OR32)xH2a+l-x group where one or more CH2 groups may be replaced by O or NR33, CD(OR32)yH2b-l-y where one or more CH2 groups may be replaced by 0 or NR33, CCH2C+1 where two or more CH2 groups are replaced by O or NR33, -(CH2)z-COOR34, -(CH2)Z -S03R34, -(CH2)Z -N+R35R36R37 where 1 or 2 hydrogen atoms of the -(CH2)Z units may be replaced by OR32 groups, -CR38R39-COOR40 or -CR38R39NR41R42; a is 2, 3, 4, 5, 6, 7 or 8; x is 2, 3, 4, 5, 6, 7 or 8; R32 is H, CH3, CH2CH3, CF3, CH2CF3, COCH3, COCH2CH3, COCF3 or COCH2CF3; R33 isH, CH3, CH2CH3, CF3orCH2CF3; b is 3, 4, 5, 6 or 7; y is 2, 3, 4, 5, 6 or 7; c is 3, 4, 5, 6, 7 or 8; z is 1 or 2; R34, R35, R36 and R37 are each independently H, CH3, CH2CH3, CF3 or CH2CF3; R38 is -(CH2)n -Y; n is 0, 1, 2, 3 or 4; Y is H, alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated and one or more CH2 groups may be replaced by O, S or NR43, or is COOR44, CONR45R46, NHC(NH)NH2, phenyl or heteroaryl, and the phenyl and heteroaryl radicals may be substituted by up to 3 substituents selected from the group of CH3, CF3, OH, OCH3 or NH2; R43, R44, R45 and R46 are each independently H, CH3, CH2CH3, CF3orCH2CF3; R39 is H, CH3, CH2CH3, CF3 or CH2CF3; R40 is H, CH3, CH2CH3, CF3 or CH2CF3; R41 and R42 are each independently H, CH3, CH2CH3, CF3, CH2CF3, COCH3, COCH2CH3, COCF3 or COCH2CF3; in which at least one of the R7, R8 or R9 radicals has to be defined by the -L-G group, and also its pharmaceutical^ acceptable salts and trifluoroacetates. Very particular preference is given to compounds of the formula I where R1, R2, R3and R4, are each independently H, F, CI, Br, CN, N02, OH, CH3, CH2CH3, CF3, CH2CF3, OCH3, OCH2CH3, OCF3, OCH2CF3, SO2R10, NR14R15, CONR16R17, COOR18 or OCOR18; R10 is CH3, CH2CH3, CF3, CH2CF3, OH or NR11R12; R11 andR12 are each independently H, CH3, CH2CH3, CF3, CH2CF3, COCH3, COCH2CH3, COCF3 or COCH2CF3; R14andR15 are each independently H, CH3, CH2CH3, CF3, CH2CF3, COCH3, COCH2CH3, COCF3 or COCH2CF3; R16andR17 are each independently H, CH3, CH2CH3, CF3 or CH2CF3; R18 isH, CH3, CH2CH3, CF3orCH2CF3; R5 is CH3; R6 is H; R7, R8 and R9 are each independently H, F, CI, Br, I, OH, CH3, CH2CH3, CF3, CH2CF3, OCH3, OCH2CH3, OCF3, OCH2CF3, S02R47, SO3R6O, COR47, COOR60, NR51R52 or a -L-G group; R47 is H, CH3, CH2CH3, CF3, CH2CF3 or NR48R49; R48 and R49 are each independently H, CH3, CH2CH3, CF3, CH2CF3, COCH3, COCH2CH3, COCF3 or COCH2CF3, or R48 and R49 together with the nitrogen atom which bonds them together form a 5- or 6-membered ring from the group of 1-pyrrolyl, 1-piperidinyl, 1-piperazinyl, 1-N-methylpiperazinyl and 4-morpholinyl; R60 is H, CH3, CH2CH3, CF3, CH2CF3; R51 and R52 are each independently H, CH3, CH2CH3, CF3, CH2CF3, COCH3, COCH2CH3, COCF3 or COCH2CF3 or R51 and R52 together with the nitrogen atom which bonds them together form a 5- or 6-membered ring from the group of 1-pyrrolyl, 1-piperidinyl, 1-piperazinyl, 1-N-methylpiperazinyl and 4-morpholinyl; L is -CH2-, -0-, -NR30-, -OCO-, -NR30CO-, -NR30CS-, -NR30SO2-, -CONR30-, -COO-, -CSNR30-, -SO2NR30-, -NR30CONR31-, -NR30COO-, -NR30CSNR31- or -NR30SO2NR31-; R30 and R31 are each independently H, CH3, CH2CH3, CF3 or CH2CF3; G is a group Ca(OR32)xH2a+i-x where one or more CH2 groups may be replaced by O or NR33, Cb(OR32)yH2b-i-y where one or more CH2 groups may be replaced by O or NR33, CCH2C+1 where two or more CH2 groups are replaced by O or NR33, -(CH2)z-COOR34, -(CH2)Z -S03R34, -(CH2)Z -N+R35R36R37 where 1 or 2 hydrogen atoms of the -(CH2)Z units may be replaced by OR32 groups, -CR38R39-COOR40 or -CR38R39NR41R42; a is 2, 3, 4, 5, 6, 7 or 8; x is 2, 3, 4, 5, 6, 7 or 8; R32 is H, CH3, CH2CH3, CF3, CH2CF3, COCH3, COCH2CH3, COCF3 or COCH2CF3; R33 is H, CH3, CH2CH3, CF3 or CH2CF3; b is 3, 4, 5, 6 or 7; y is 2, 3, 4, 5, 6 or 7; c is 3, 4, 5,6, 7 or 8; z is 1 or 2; R34, R35, R36 and R37 are each independently H, CH3, CH2CH3, CF3 or CH2CF3; R38 is -(CH2)n -Y; n is 0, 1,2, 3 or 4; Y is H, alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated and one or more CH2 groups may be replaced by O, S or NR43, or is COOR44, CONR45R46, NHC(NH)NH2, phenyl or heteroaryl, and the phenyl and heteroaryl radicals may be substituted by up to 3 substituents selected from the group of CH3, CF3, OH, OCH3 or NH2; R43, R44, R45 and R46 are each independently H, CH3, CH2CH3, CF3 or CH2CF3J R39 is H; R40 is H, CH3, CH2CH3, CF3 or CH2CF3; R41 and R42 are each independently H, CH3, CH2CH3, CF3, CH2CF3, COCH3, COCH2CH3, COCF3 or COCH2CF3; in which at least one of the R7, R8 or R9 radicals has to be defined by the -L-G group, and also its pharmaceutical^ acceptable salts and trifluoroacetates. In one embodiment, preference is given to compounds of the formula I in which R1 and R3 are described by H. In a further embodiment, preference is given to compounds of the formula I in which R2 and R4 are described by CI. In one embodiment, preference is given to compounds of the formula I in which R5 is described by H, CH3 or CF3. In another embodiment, preference is given to compounds of the formula I in which R6 is described by H, OH, CH3, CF3, OCH3 or OCOCH3, and preference is given to compounds in which R6 is described by H. In one embodiment, preference is given to compounds of the formula I in which R7, R8 and R9 are each independently described by H, OH, CH3, CF3, OCH3 S02R47, SO3R6O, COR47, COOR60, NR51R52 or a -L-G group, where R47 is H, CH3 or NR48R49; R48 and R49 are each independently H, CH3 or COCH3; R60 is H, CH3; R51 and R52 are each independently H, CH3, CH2CH3 or COCH3; L is -NR30CO-, -CONR30- or -NR30CONR31-; R30 and R31 are each H; G is a group of the form Ca(OR32)xH2a+l-x. CD(OR32)yH2b-l-y where one CH2 group may be replaced by O, CCH2C+1 where two or more CH2 groups are replaced by O or NR33, -(CH2)2-COOH, - (CH2)2 -S03H, -(CH2)2 -N+(CH3)3 where 1 or 2 hydrogen atoms of the -(CH2)2 units may be replaced by OH groups, -CR38R39- COOR40 or -CR38R39NR41R42 a is 3, 4, 5 or 6; x is 2, 3, 4 or 5; R32 is H; b is 5 or 6; y is 2, 3, 4 or 5; c is 6, 7 or 8; R33 isHorCH3; R38 is H, alkyl having 1, 2, 3 or 4 carbon atoms, CH2OH, CH2SH, CH2NH2, CH(OH)CH3, CH2CH2SCH3, CH2CH2CH2NH2, CH2CH2CH2CH2NH2) CH2CH2CH2NHC(NH)NH2, CH2COOH, CH2CONH2, CH2CH2COOR44, CH2CH2CONH2, COOH, phenyl, 4-hydroxyphenyl, 4-imidazolyl or 3-indolyl; R39 is H; R40 isH,CH3orCH2CH3; R41 and R42 are each independently H, CH3 or COCH3; R44 isH, CH3orCH2CH3; in which at least one of the R7, R8 or R9 radicals has to be defined by the -L-G group. In one embodiment, preference is given to compounds of the formula I in which one of the R7, R8 or R9 radicals is described by LG and the other R7, R8, R9 radicals by H, OH, CH3, CF3, OCH3) S02R47, SO3R6O, COR47, COOR60 or NR51R52, in particular by hydrogen or COOH; particular preference is given to compounds of the formula lt in which one of the R7, R8 or R9 radicals is described by LG and the other R7, R8, R9 radicals are each described by H. In one embodiment, preference is given to compounds of the formula I in which two of the R7, R8 or R9 radicals are each described by LG and one of the R7, R8 or R9 radicals by hydrogen. Especially preferred are compounds of the formula I selected from the group of N-[4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-2,3,4,5,6- pentahydroxyhexanamide, N-p^e^-dichloro^-methyl-l^^^-tetrahydroisoquinolin^-yOphenyl^.S^^.e^ pentahydroxyhexanamide, N-[2-(6,8-dichloro-2-methyl^ pentahydroxyhexanamide, N-[3-((S)-6,8-dichloro-2-m^ pentahydroxyhexanamide, N-[3-((R)-6,8-dichloro-2-m^ pentahydroxyhexanamide, 1-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-3-(2-hydroxy~1- hydroxymethylethyl)urea, 1-[3-(6,8-dichloro-2-methyl-t^ bishydroxymethylethyl)urea, The groups of the form Ca(OR32)xH2a+i-x described under G may be either straight-chain or branched. This results in polyhydroxylated alkyi chains, as derived, for example, from monosaccharide building blocks, which are bonded to the phenyl radical via a linker unit L. Correspondingly, the formula Cb(OR32)yH2b-i-y preferably describes polyhydroxylated, cyclic alkyl substituents. Exchange of a CH2 unit for O results, for example, in the class of the pyranoside orfuranoside carbohydrate building blocks, as realized in example 9. G may equally derive from the group of the amino acids, which are bonded via the amino acid amino or amino acid carboxyl function, in which case the amino or carbonyl function is included in the linker unit L. The amino acid side chains then occur in R38. When the compounds of the formula I contain one or more centers of asymmetry, these may each independently have either the S or R configuration. The compounds may be present as optical isomers, as enantiomers, as diastereomers, as racemates or as mixtures in any ratios thereof. The present invention includes all tautomeric forms of the compounds of the formula I. Alkyl radicals may be straight-chain or branched. This also holds when they bear substituents or occur as substituents of other radicals, for example in fluoroalkyl radicals or alkoxy radicals. Examples of alkyl radicals are methyl, ethyl, n-propyl, isopropyl (= 1-methylethyl), n-butyl, isobutyl (= 2-methylpropyl), sec-butyl (= 1-methylpropyl), tert-butyl (= 1,1-dimethylethyl), n-pentyl, isopentyl, tert-pentyl, neopentyl, hexyl, heptyl, octyl. Preferred alkyl radicals are methyl, ethyl, n-propyl, isopropyl, n-butyl, tert-butyl, n-pentyl, n-hexyl. In the alkyl radicals, one or more, for example 1, 2, 3,4,-5,6,7, 8, 9, 10, 11, 12, 13, 14, 15, 16 or 17, hydrogen atoms may be substituted by fluorine atoms. Examples of such fluoroalkyl radicals are trifluoromethyl, 2,2,2-trifluoroethyl, pentafluoroethyl, heptafluoroisopropyl. Substituted alkyl radicals may be substituted in any desired positions, for example by hydroxy!. In the alkyl radicals, one or more CH2 groups may be replaced by O, NH or N-alkyl. Alkenyl radicals may be straight-chain or branched. This also holds when they bear substituents, for example in fluoroalkenyl radicals. The alkenyl radicals may be unsaturated in different positions. Examples of alkenyl radicals are propenyl, butenyl, pentenyl, hexenyl or heptenyl. In alkenyl radicals, one or more, for example 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or 13, hydrogen atoms may be substituted by fluorine atoms. Substituted alkenyl radicals may be substituted in any desired positions, for example by hydroxyl. In the alkenyl radicals, one or more CH2 groups may be replaced by O, NH or N-alkyl. Acyl radicals may be straight-chain or branched. This is also true when they bear substituents. Examples of acyl radicals are formyl, acetyl, propionyl or butyryl. In acyl radicals, one or more, for example 1, 2, 3, 4, 5, 6 or 7, hydrogen atoms may be substituted by fluorine atoms. Examples of cycloalkyl radicals are cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl or cyclooctyl. In cycloalkyl radicals, one or more, for example 1,2,3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or 13, hydrogen atoms may be substituted by fluorine atoms. Substituted cycloalkyl radicals may be substituted in any desired positions, for example by hydroxyl. The cycloalkyl radicals may also be in branched form as alkylcycloalkyl or cycloalkylalkyl, for example methylcyclohexyl or cyclohexylmethyl. In the cycloalkyl radicals, one or more CH2 groups may be replaced by O, NH or N-alkyl. Phenyl radicals may be unsubstituted or singly or multiply, for example singly, doubly or triply, substituted by identical or different radicals. When a phenyl radical is substituted, it preferably bears one or two identical or different substituents. This applies equally to substituted phenyl radicals in groups such as phenylalkyl, phenylcarbonyl, etc. Phenylalkyl radicals are, for example, benzyl, 1-phenylethyl or 2-phenylethyl. In monosubstituted phenyl radicals, the substituent may be in the 2-position, the 3-position or the 4-position. Disubstituted phenyl may be substituted in the 2,3-position, 2,4-position, 2,5-position, 2,6-position, 3,4-position or 3,5-position. In trisubstituted phenyl radicals, the substituents may be in the 2,3,4-position, 2,3,5-position, 2,4,5-position, 2,4,6-position, 2,3,6-position or 3,4,5-position. Heteroaryl radicals are aromatic ring compounds in which one or more ring atoms are oxygen atoms, sulfur atoms or nitrogen atoms, for example 1, 2, 3 or 4 nitrogen atoms, 1 or 2 oxygen atoms, 1 or 2 sulfur atoms or are combinations of different heteroatoms. The heteroaryl radicals may be bonded via all positions, for example via the 1-position, 2-position, 3-position, 4-position, 5-position, 6-position, 7-position or 8-position. Heteroaryl radicals may be unsubstituted or singly or multiply, for example singly, doubly or triply, substituted by identical or different radicals. Heteroaryls are, for example, 2- or 3-thienyl, 2- or 3-furyl, 1-, 2- or 3-pyrroIyl, 1-, 2-, 4- or 5-imidazolyl, 1-, 3-, 4- or 5-pyrazolyl, 1,2, 3-triazol-1-, -4- or-5-yl, 1,2,4-triazol-1-, -3- or-5-yl, 1-or5-tetrazolyl, 2-, 4- or 5-oxazolyl, 3-, 4- or 5-isoxazolyl, 1,2,3-oxadiazol-4- or -5-yl, 1,2,4-oxadiazol-3- or -5-yl, 1,3,4-oxadiazol-2-yl or -5-yl, 2-, 4- or 5-thiazolyl, 3-, 4- or 5-isothiazolyl, 1,3,4-thiadiazol-2-or-5-yl, 1,2,4-thiadiazol-3-or-5-yl, 1,2,3-thiadiazol-4-or -5-yl, 2-, 3- or 4-pyridyl, 2-, 4-, 5- or 6-pyrimidinyl, 3- or 4-pyridazinyI, pyrazinyl, 1-, 2-, 3-, 4-, 5-, 6- or 7-indolyl, 1-, 2-, 4- or 5-benzimidazolyl, 1-, 3-, 4-, 5-, 6- or 7-indazolyl, 2-, 3-, 4-, 5-, 6-, 7- or 8-quinolyl, 1-, 3-, 4-, 5-, 6-, 7- or 8-isoquinolyl, 2-, 4-, 5-, 6-, 7- or 8-quinazolinyl, 3-, 4-, 5-, 6-, 7- or 8-cinnolinyl, 2-, 3-, 5-, 6-, 7- or 8-quinoxalinyl, 1-, 4-, 5-, 6-, 7- or 8-phthalazinyl. Also included are the corresponding N-oxides of these compounds, i.e., for example, 1-oxy-2-, 3- or 4-pyridyl. Preference is given to the 5- or 6-membered heterocycles, for example imidazolyl, pyrazolyl, pyrrolyl, triazolyl, tetrazolyl, thiazolyl and oxazolyl and pyridyl. Also included as CH2 units are the CH3 groups which terminate an alkyl chain, which are interpreted in this context as CH2-H groups. Also described are methods for preparing the compounds of the formula I. The compounds of the formula I described here can be prepared starting from the benzylamine precursors IV. If not commercially obtainable, these can in turn be synthesized by standard methods known to those skilled in the art from the corresponding benzyl chlorides or bromides III and the corresponding amine. The benzylamines IV obtained in this way are alkylated in a manner known to those skilled in the art with the appropriately substituted alpha-bromoacetophenone compounds V. The alpha-bromoacetophenone compounds V can be obtained in literature methods from the corresponding acetophenone precursors by bromination. By reduction of the carbonyl groups in VI and subsequent acid-catalyzed cyclization of the resulting alcohols VII (cf. Tetrahedron Lett.; 1989,30, 5837; Org. Prep. Proced. Int.; 1995, 27, 513) the desired tetrahydroisoquinolines I can be obtained by known methods. When R6 is not H, the desired compounds of the formula I can be prepared, for example, from the iodides VIII (cf. Chem. Pharm. Bull.; 1994, 42, 67) by halogen-metal exchange and subsequent nucleophilic attack of the intermediate organolithium species on the carbonyl group (cf. Chem. Pharm. Bull.; 1995, 43, 1543). The tertiary alcohols IX synthesized in this way can be converted by known methods to further derivatives, for example the ethers or esters derived therefrom. To prepare alkyl-branched analogs (I), the appropriate diphenylacetic esters X can be alkylated in the alpha-position with R6 by known methods. The desired products XI can be converted by standard methods to the corresponding amides XII which are converted to the desired tetrahydroisoquinolines I in a Pictet-Spengler-like reaction (cf. Tetrahedron; 1987, 43, 439; Chem. Pharm. Bull.; 1985, 33, 340). The bonding of the L-G substituents to the R7, R8 or R9 positions may, for example, be via an amide bond. In this case, the above-described synthetic routes ensure that at least one of the R7, R8 or R9 radicals is present as an NH2 or COOH group. A polar radical can be bonded in a manner known to those skilled in the art by coupling polar carboxylic acids (for example gluconic acid which has to be appropriately protected) to the NH2 compound XIII or by coupling polar amines (for example glucamine) to the corresponding -COOH compound XIV, resulting in the carboxanilides la or the carboxamides lb. In the compounds of the formulae II to XIV, the R1 to R9 radicals are each as defined above or they are functional groups in protected form or in precursor stages. The urea or else thiourea compounds derived from the precursor molecules XIII can likewise be prepared therefrom in a manner known to those skilled in the art. It has been possible to show that compounds of the formula I constitute outstanding inhibitors of the sodium-hydrogen exchanger (NHE), especially of the sodium-hydrogen exchanger of the subtype 3 (NHE3). Tetrahydroisoquinolines as inhibitors of the sodium-hydrogen exchanger of the subtype 3 (NHE3) have already been described in the patent application WO03048129. The patent application WO03055880 describes the related compound class of the tetrahydroisoquinolinium salts as NHE3 inhibitors. However, the properties of these compounds are not yet satisfactory in various respects, and there is still a need for compounds having a more favorable pharmacodynamic or pharmacokinetic property profile, and suitable for treating highly differing disorders. The NHE3 is found in the body of various species, preferably in the gallbladder, the intestines and in the kidneys (Larry Fliegel et al., Biochem. Cell. Biol. 76: 735-741, 1998), but could also be found in the brain (E. Ma et al., Neuroscience 79: 591-603). As a consequence of their unexpected NHE-inhibitory properties, the compounds of the formula I are suitable for preventing and treating disorders which are caused by activation and/or by an activated NHE. The use of the inventive compounds relates to the prevention and treatment of acute and chronic disorders in veterinary medicine and human medicine. Thus, the inventive inhibitors of NHE are suitable for treating disorders which are caused by ischemia and/or by reperfusion. As a consequence of their pharmacological properties, the compounds described here are outstandingly suitable as antiarrhythmic medicaments having a cardioprotective component for prophylaxis of infarction and for treatment of infarction, and also for treatment of angina pectoris, in which case they also inhibit or greatly reduce, in a preventative manner, the pathophysiological events in the development of ischemia-induced damage, in particular in the induction of ischemia-induced cardiac arrhythmias. Owing to their protective effects against pathological hypoxic and ischemic situations, the compounds of the formula I used in accordance with the invention can, as a consequence of inhibition of the cellular Na+/H+ exchange mechanism, be used as a medicament for treating all acute or chronic damage induced by ischemia or disorders induced primarily or secondarily thereby. This relates to the use thereof as medicaments for surgical interventions, for example in organ transplants, in which case the compounds can be used both for the protection of the organs in the donor and during the removal, to protect removed organs, for example in the course of treatment with or storage thereof in physiological bath fluids, and also in the course of transfer into the recipient organism. The compounds are likewise valuable medicaments having a protective action when carrying out angioplastic surgical interventions, for example on the heart or else on peripheral vessels. In accordance with their protective action against ischemia-induced damage, the compounds are also suitable as medicaments for treating ischemias of the nervous system, especially of the CNS, in which case they are suitable, for example, for treating stroke or cerebral edema. In addition, the compounds of the formula I used in accordance with the invention are likewise suitable for treating forms of shock, for example allergic, cardiogenic, hypovolemic and bacterial shock. In addition, the compounds induce an improvement in the respiratory drive and are therefore used for treating respiratory conditions in the event of the following clinical conditions and disorders: disrupted central respiratory drive (for example central sleep apneas, sudden infant death, postoperative hypoxia), muscle-related respiratory disorders, breathing disorders after long-term ventilation, breathing disorders in the course of adaptation in high mountains, obstructive and mixed form of sleep apneas, acute and chronic pulmonary disorders with hypoxia and hypercapnia. The compounds additionally increase the muscle tone of the upper airways, so that snoring is suppressed. The compounds mentioned are therefore advantageously used to prepare a medicament for the prevention and treatment of sleep apneas and muscle-related respiratory disorders and to prepare a medicament for the prevention and treatment of snoring. A combination of an NHE inhibitor with a carbonic anhydrase inhibitor (for example acetazolamide), in which case the latter brings about metabolic acidosis and thus itself increases respiratory activity, is found to be advantageous as a result of enhanced action and reduced use of active ingredient. In addition, the compounds described here are suitable as medicaments for therapy and prophylaxis of diseases and disorders which are induced by hyperexcitability of the central nervous system, in particular for treating diseases of the epileptic type, centrally induced clonic and tonic spasms, states of psychological depression, anxiety disorders and psychoses. The NHE inhibitors described here may be employed alone or in combination with other antiepileptic substances or antipsychotic active ingredients, or carbonate dehydratase inhibitors, for example with acetazolamide, and also with further inhibitors of NHE or of the sodium-dependent chloride-bicarbonate exchanger (NCBE). It has been found that the compounds used in accordance with the invention have a mild laxative effect and can accordingly be used advantageously as laxatives or in the event of risk of constipation. In addition, the inventive compounds can advantageously be used for the prevention and therapy of acute and chronic disorders of the intestinal tract which are induced by ischemic states in the intestinal region and/or by subsequent reperfusion. Such complications may be caused, for example, by inadequate bowel peristalsis as frequently observed, for example, after surgical interventions, in the event of constipation or greatly reduced bowel activity. There is also the possibility of preventing gallstone formation. In addition, the compounds of the formula I used in accordance with the invention feature strong inhibiting action on the proliferation of cells, for example on fibroblast cell proliferation and the proliferation of smooth vascular muscle cells. The compounds of the formula I are therefore useful as valuable therapeutic agents for disorders in which cell proliferation constitutes a primary or secondary cause, and can therefore be used as antiatherosclerotic agents, agents against diabetic late complications, agents against chronic kidney failure, cancers, fibrotic disorders of the heart and also as pulmonary fibrosis, hepatic fibrosis, or renal fibrosis, organ hypertrophies and hyperplasias, for example of the heart and the prostate, and thus for the prevention and treatment of congestive heart failure or in the event of prostate hyperplasia or prostate hypertrophy. The inventive compounds are effective inhibitors of the cellular sodium-proton antiporter (Na/H exchanger) which is elevated in numerous disorders (essential hypertension, atherosclerosis, diabetes, etc.), also in those cells which are readily amenable to measurements, for example in erythrocytes, thrombocytes or leucocytes. The compounds used in accordance with the invention are therefore suitable as outstanding and simple scientific tools, for example in their use as diagnostic agents for determining and differentiating different forms of hypertension, but also of atherosclerosis, diabetes and diabetic late complications, proliferative disorders, etc. In addition, the compounds of the formula I are suitable for preventive therapy for preventing development of, and treating, high blood pressure, for example of essential hypertension, since they reduce or fully inhibit the reabsorption of NaCI in the tubular system of the kidneys. Accordingly, they are also outstandingly suitable as combination and formulation partners for medicaments which are used to treat high blood pressure. For example, they may be combined with diuretics having thiazide-like action, loop diuretics, aldosterone and pseudoaldosterone antagonists such as hydrochlorothiazide, indapamide, polythiazide, furosemide, piretanide, torasemide, bumetanide, amiloride, triamterene. In addition, the NHE inhibitors of the present invention may be used in combination with ACE inhibitors, for example ramipril, enalapril or captopril. Further favorable combination partners are also p-blockers. The NHE inhibitors described may likewise be used in the prevention of, and for treating, thrombotic disorders, since, as NHE inhibitors, they can both inhibit platelet aggregation itself and additionally inhibit or prevent the excessive release of coagulation mediators, in particular of von Willebrand's factor. The NHE inhibitors of the present invention can therefore be combined with further anticoagulant active ingredients, for example acetylsalicylic acid, thrombin antagonists, factor Xa antagonists, medicaments having fibrinolytic action, factor Vila antagonists, etc. Combined application of the present NHE inhibitors with NCBE inhibitors is particularly beneficial. It has also been found that NHE inhibitors exhibit a beneficial influence on serum lipoproteins. It is generally acknowledged that excessively high blood lipid levels, known as hyperlipoproteinemias, constitute a significant risk factor for the development of arteriosclerotic vascular lesions, especially of coronary heart disease. The reduction in elevated serum lipoproteins is therefore exceptionally important for the prophylaxis and the regression of atherosclerotic lesions. The compounds used in accordance with the invention can therefore be used for prophylaxis and for regression of atherosclerotic lesions by eliminating a causal risk factor. The inventive inhibitors of NHE can also advantageously be combined with other antiarteriosclerotic active ingredients, such as a substance from the class of the fibrates, an upregulator of LD2 receptor activity, such as MD-700 and LY295427, or a cholesterol or bile acid resorption inhibitor or an antihypercholesterolemic from the class of the statins, such as, for example, pravastatin, lovastatin, simvastatin. This protection of the vessels against the syndrome of endothelial dysfunction makes compounds of the formula I viable medicaments for preventing and for treating coronary vasospasms, peripheral vascular disorders, such as claudicatio intermittens, atherogenesis and atherosclerosis, left-ventricular hypertrophy and dilated cardiomyopathy, and thrombotic disorders. The compounds mentioned may likewise be used for treating diseases which are caused by protozoa and are especially suitable as antimalarials. In addition, the compounds are suitable for controlling sucking parasites such as mosquitoes, ticks, fleas and plant pests. In accordance with their protective actions, the compounds are also suitable as medicaments for maintaining health and prolonging life. Generally, the NHE inhibitors described here may advantageously be combined with other compounds which regulate the intracellular pH, and useful combination partners are inhibitors of the enzyme group of carbonate dehydratase, inhibitors of bicarbonate ion-transporting systems such as the sodium-bicarbonate cotransporter or the sodium-dependent chloride-bicarbonate exchanger, and also other NHE inhibitors, for example having inhibitory action on other NHE subtypes, because they may strengthen the pharmacologically relevant pH-regulating effects of the NHE inhibitors described here. The compounds mentioned therefore advantageously find use for preparing a medicament for preventing and treating sleep apneas and muscle-related respiratory disorders; for preparing a medicament for preventing and treating snoring; for preparing a medicament for blood pressure reduction; for preparing a medicament having a laxative effect for preventing and treating intestinal blockages; for preparing a medicament for preventing and treating disorders which are induced by ischemia and reperfusion of central and peripheral organs such as acute renal failure, stroke, endogenous states of shock, intestinal disorders, etc.; for preparing a medicament for treating diabetic late damage and chronic renal disorders, in particular all renal inflammations (nephritides) which are associated with increased protein/albumin excretion; for preparing a medicament for treating hypercholesterinemia; for preparing a medicament for preventing atherogenesis and atherosclerosis; for preparing a medicament for preventing and treating disorders which are induced by elevated cholesterol levels; for preparing a medicament for preventing and treating disorders which are induced by endothelial dysfunction; for preparing a medicament for treating infection by ectoparasites; for preparing a medicament for treating the diseases mentioned in combinations with blood pressure-reducing substances, preferably with angiotensin converting enzyme (ACE) inhibitors, with diuretics, aldosterone antagonists or angiotensin receptor antagonists. It has been found that a combination of an NHE inhibitor of the formula I with a blood lipid level-reducing active ingredient, preferably with an HMG-CoA reductase inhibitor (for example lovastatin or pravastatin), the latter bringing about hypolipidemic action and thus increasing the hypolipidemic properties of the NHE inhibitor of the formula I, is a beneficial combination having enhanced action and reduced use of active ingredient. The administration of sodium-proton exchange inhibitors of the formula I as novel medicaments for reducing elevated blood lipid level is claimed, as is the combination of sodium-proton exchange inhibitors with blood pressure-reducing and/or hypolipidemic medicaments. The invention also relates to curative compositions for human, veterinary or phytoprotective use, comprising an effective amount of a compound of the formula I and/or of a pharmaceutical^ acceptable salt thereof, as well as curative compositions for human, veterinary or phytoprotective use, comprising an effective amount of a compound of the formula I and/or of a pharmaceutical^ acceptable salt thereof alone or in combination with one or more other pharmacological active ingredients or medicaments. Medicaments which comprise a compound of the formula I or the pharmaceutical^ acceptable salts thereof can be administered, for example, orally, parenterally, intramuscularly, intravenously, rectally, nasally, by inhalation, subcutaneously or by a suitable transcutaneous dosage form, the preferred administration depending on the particular characteristics of the disorder. The compounds of the formula I can be used alone or together with pharmaceutical excipients, in veterinary or in human medicine and in plant protection. The medicaments comprise active ingredients of the formula I and/or their pharmaceutical^ acceptable salts in general in an amount of from 0.01 mg to 1 g per dose unit. The excipients which are suitable for the desired pharmaceutical formulation are familiar to those skilled in the art on the basis of their expert knowledge. In addition to solvents, gel formers, suppository bases, tablet excipients and other active ingredient carriers, it is possible to use, for example, antioxidants, dispersants, emulsifiers, antifoams, flavorings, preservatives, solubilizers or colorings. For an oral administration form, the active compounds are mixed with the additives suitable for this purpose, such as carriers, stabilizers or inert diluents and converted by customary methods to the suitable dosage forms, such as tablets, coated tablets, hard gelatin capsules, aqueous, alcoholic or oily solutions. Examples of useful inert carriers include gum arabic, magnesia, magnesium carbonate, potassium phosphate, lactose, glucose or starch, in particular corn starch. The preparation may be either in the form of dry granules or in the form of moist granules. Examples of useful oily carriers or useful solvents are vegetable or animal oils, such as sunflower oil or cod liver oil. For subcutaneous, percutaneous or intravenous administration, the active compounds used, if desired with the substances customary for this purpose such as solubilizers, emulsifiers or further excipients are converted to solution, suspension or emulsion. Examples of useful solvents are: water, physiological saline or alcohols, for example ethanol, propanol, glycerol and additionally also sugar solutions such as glucose or mannitol solutions, or else a mixture of the different solvents mentioned. Examples of suitable pharmaceutical formulations for administration in the form of aerosols or sprays are solutions, suspensions or emulsions of the active ingredient of the formula I in a pharmaceutical^ acceptable solvent, in particular ethanol or water, or a mixture of such solvents. If required, the formulation may also comprise other pharmaceutical excipients such as surfactants, emulsifiers and stabilizers, and also a propellant gas. Such a preparation typically contains the active ingredient in a concentration of from about 0.1 to 10% by weight, in particular from about 0.3 to 3% by weight. The dosage of the active ingredient of the formula I to be administered and the frequency of administration depend on the potency and duration of action of the compounds used; additionally also on the nature and severity of the disease to be treated, and also on the gender, age, weight and individual responsiveness of the mammal to be treated. On average, the daily dose of a compound of the formula I in the case of a patient weighing about 75 kg is at least 0.001 mg/kg, preferably 0.1 mg/kg, up to at most 30 mg/kg, preferably 1 mg/kg, of body weight. In the event of acute episodes of the disease, for instance immediately after suffering apnetic states in high mountains, even higher dosages may be necessary. Especially in the case of i.v. administration, for instance in a heart attack patient in the intensive care unit, up to 300 mg/kg per day may be necessary. The daily dose can be divided into one or more, for example up to 4, individual doses. When the compounds of the formula I contain one or more acidic or basic groups and/or one or more basic heterocycles, the corresponding physiologically or toxicologically acceptable salts are also included in the invention, in particular the salts which can be used pharmaceutically. For instance, the compounds of the formula I can be deprotonated at an acidic group and be used, for example, as alkali metal salts, preferably sodium or potassium salts, or as ammonium salts, for example as salts with ammonia or organic amines or amino acids. Compounds of the formula I which contain a basic group can also be used in the form of their physiologically acceptable acid addition salts with inorganic or organic acids, for example as hydrochlorides, phosphates, sulfates, methanesulfonates, acetates, lactates, maleates, fumarates, malates, gluconates, etc. Experimental descriptions and examples List of abbreviations used: Rt Retention time TFA Trifluoroacetic acid HPLC High Performance Liquid Chromatography eq equivalents LCMS Liquid Chromatography Mass Spectroscopy MS Mass Spectroscopy ESI Electrospray ionization RT Room temperature THF Tetrahydrofuran TOTU ©-[(EthoxycarbonyOcyanomethyleneaminoJ-N^^'^'-tetramethyluronium tetrafluoroborate DMSO Dimethyl sulfoxide abs. absolute decomp. decomposition DMF Dimethylformamide DMAP 4-Dimethylaminopyridine HOBt 1-Hydroxybenzotriazole DIC Diisopropylcarbodiimide ACN Acetonitrile DEA Diethylamine Example 1: N-[4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-(2R,3S)4R,5R)-2J3)4,5,6-pen:ahydroxyhexanamide Intermediate 1: 2,4-dichlorobenzylmethylamine was prepared by literature methods (J. Med. Chem.; 1984, 27, 1111). Intermediate 2: N-[4-(2-bromoacetyl)phenyl]acetamide was synthesized in a manner known to those skilled in the art by brominating N-(4- acetylphenyl)acetamide. The starting compound (0.256 mol) is initially charged in 300 ml of acetic acid and a solution of 39.9 g of bromine (1.0 eq) in 60 ml of acetic acid was added dropwise at 60°C. After 1.5 hours, the mixture was cooled to room temperature and the reaction mixture was added to 1 I of ice-water. The precipitate was filtered off with suction, washed with water and dried to isolate 60 g of the title compound (m.p.: 192°C). Intermediate 3: N-{4-[2-(2,4-dichlorobenzylamino)acetyl]phenyl}acetamide 37.1 g (0.195 mol) of intermediate 1 were initially charged in 400 ml of dioxane and admixed with a solution of 60 g (0.234 mol) of intermediate 2 in 600 ml of dioxane. 134 ml of triethylamine were added and the mixture was stirred at room temperature for 4 h. After standing overnight, the precipitate was filtered off and the filtrate concentrated in vacuo. The residue was taken up in ethyl acetate, washed with NaHC03 and H20, dried with MgS04 and concentrated. The resulting oily residue was triturated with an ethyl acetate/ether mixture to obtain 36 g of intermediate 3 in the form of a crystalline solid (m.p.: 115-117°C). Intermediate 4: N-{4-[2-(2,4-dichlorobenzylamino)-1«hydroxyethyl]phenyl}acetamide 36 g (0.099 mol) of intermediate 3 were dissolved in 500 ml of methanol and admixed at 0°C with 7.8 g (2 eq) of sodium borohydride. The mixture was stirred at 0°C for another 30 min and at room temperature for a further hour. For workup, the reaction mixture was concentrated and the residue partitioned between 1 N HCI and ethyl acetate. The aqueous phase was removed, adjusted to pH 9 and extracted twice with ethyl acetate. The combined organic phases were dried with MgS04 and concentrated. The crude product obtained in this way could be used further without further purification. Intermediate 5: N-[4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]acetamide 20 g (0.054 mol) of intermediate 4 were dissolved in 250 ml of dichloromethane and admixed dropwise at 0°C with 250 ml of cone. H2S04. The mixture was stirred at 0°C for 2 h and at room temperature for 1 h. For workup, the reaction mixture was added to diisopropyl ether to isolate 11.7 g of the title compound as a crystalline solid (m.p.: 205-206°C). Intermediate 6: 4-(6,8-dichioro-2-methyI-1 ,2,3,44etrahydroisoquinolin-4-yl)phenylamine 3.0 g (8.6 mmol) of N-^S^-dichloro^-methyl-l^^^-tetrahydroisoquinolin^-yl)phenyl]acetamide (intermediate 5) were dissolved in 100 ml of 20% sodium ethoxide solution and heated to reflux for 4 hours. A further 2.0 g (29.4 mmol) of solid sodium ethoxide were added and the mixture was heated to reflux for another 3 hours. For workup, the solvent was removed in vacuo, and the residue was taken up in 200 ml of H20 and extracted twice with dichloromethane. The combined organic phases were dried with MgS04 and concentrated. For further purification, chromatography was effected on silica gel (1:1 ethyl acetate/heptane) to obtain the aniline as a yellowish oil in quantitative yield. Intermediate 7: 2,3,4,5,6-penta-C-acetylgluconyl chloride The title compound was synthesized by literature methods (Org. Syntheses, 1961, 41, 79-82). Intermediate 8: N-[4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-(2R,3S,4R)5R)-2,3,4,5,6-penta-0-acetylhexanamide 614 mg (2.0 mmol) of 4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenylamine (intermediate 6) were initially charged in 20 ml of pyridine and admixed at 0°C with a solution of 1.28 g (3.0 mmol) of 2,3,4,5,6-penta-O-acetylgluconyl chloride in 10 ml of dichloromethane. The mixture was stirred at 0°C for 15 minutes and at room temperature for 1 hour. For workup, the mixture was concentrated and the residue taken up in dichloromethane. Washing was effected once with H2O, once with saturated NaHCC>3 solution, twice with 1 N HCI and once more with H20, followed by drying over MgS04 and concentration. The crude product obtained in this way (1.12 g) could be used in the next reaction without further purification. 1: N-[4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yi)phenyl]-(2R,3S,4R,5R)-2,3,4,5)6-pentahydroxyhexanamide; The crude product obtained in intermediate 8 was dissolved in 30 ml of methanol and admixed in portions at room temperature with 452 mg (8.4 mmol) of sodium methoxide. After one to two hours at room temperature, the pH was adjusted to about 7 using 1 N HCI and the solvent removed in vacuo. The residue was taken up in sat. NaHC03 solution and extracted twice with ethyl acetate. The combined organic phases were dried over MgS04 and concentrated. Chromatography on silica gel using a dichloromethane/methanol mixture afforded 373 mg of the title compound as a pale yellow solid. 1a: N-K-Ce.S-dichloro^-methyl-l^^^-tetrahydroisoquinolin^-yOphenyl]-(2R,3S,4R,5R)-2,3,4,5J6-pentahydroxyhexanamide hydrochloride; 201 mg (0.4 mmol) of ^-(e^-dichloro^-methyl-l^^^-tetrahydroisoquinolin^-yl)phenyl]-(2R,3S,4R,5R)-2,3A5,6-pentahydroxyhexanamide (example compound 1) were taken up in 75 ml of H20 and admixed at room temperature with 4.14 ml of 0.1 M HCI. The mixture was stirred for 15 minutes, filtered and freeze-dried to obtain 177 mg of the desired hydrochloride. Example 2: N-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanamide Intermediate 1: 3-(6,8-dichloro-2-methyl-1 ,2,3,4-tetrahydroisoquinolin-4-yl)phenylamine Starting from 2,4-dichlorobenzylmethylamine (Example 1, intermediate 1) and N-[3-(2-bromoacetyl)phenyi]acetamide (cf. Example 1, intermediate 2), the aniline derivative 3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenylamine (cf. Example 1, intermediate 6) was prepared in a similar manner to the synthetic route described in Example 1. Intermediate 2: N-[3-(6,8-dichloro-2-methyI-1,2,3,4-tetrahydroisoquinoiin-4-yl)phenyi]-(2R,3SJ4R,5R)-2)3,4,5,6-penta-0-acetylhexanamide 3.1 g (10 mmol) of S^.S-dichloro^-methyl-l^^^-tetrahydroisoquinolin^-yl)phenylamine (intermediate 1) were dissolved in 100 ml of pyridine and admixed at 0°C with a solution of 1.2 equivalents of 2,3,4,5,6-penta-O-acetylgluconyl chloride in 60 ml of dichloromethane. The mixture was stirred at room temperature. Once the monitoring of the reaction indicated complete conversion, the mixture was concentrated and the residue taken up in dichloromethane. Washing was effected once with H20, once with saturated NaHCCb solution, twice with 1 N HCI and once more with H20, followed by drying over MgS04 and concentration. The crude product obtained in this way (6.91 g) could be used in the next reaction without further purification. 2: N-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanamide 6.91 g of the crude product from intermediate 2 were admixed into 200 ml of methanol at room temperature with 2.79 g (51.7 mmol) of sodium methoxide. After 1 to 2 hours at room temperature, the pH was adjusted to about 7 using 1 N HCI and the solvent was removed in vacuo. The residue was taken up in sat. NaHC03 solution and extracted twice with ethyl acetate. The combined organic phases were dried over MgS04 and concentrated. Chromatography on silica gel using a dichloromethane/methanol mixture afforded 2.05 g of the title compound as a pale yellow solid. 2a: N-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanamide hydrochloride 300 mg (0.6 mmol) of N-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanamide (example compound 2) were taken up in 100 ml of H2O and admixed at room temperature with 6.18 ml of 0.1 M HCI. The mixture was stirred for 15 minutes, filtered and freeze-dried to obtain 294 mg of the desired hydrochloride. Example 3: N-[2-(6,8-dichloro-2-methyl-1 ,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanamide Intermediate 1: N-[2-(2-bromoacetyl)phenyl]acetamide 31 g (0.175 mol) of N-(2-acetylphenyl)acetamide (prepared by acylating 2-aminoacetophenone with acetyl chloride according to Fuerstner, Alois; Jumbam, Denis N.; Tetrahedron; 48; 29; 5991-6010, (1992)) were dissolved in 200 ml of glacial acetic acid. 127 ml of 33% HBr in glacial acetic acid were added and then 8.75 ml (0.175 mol) of bromine were added slowly at room temperature. The mixture was stirred at room temperature overnight. The mixture was stirred into 1.5 I of ice-water, and the precipitated product was filtered off with suction, washed thoroughly with ice-water and dried in vacuo. According to HPLC and NMR, the crude product contained some reactant and dibrominated product, but was clean enough for the further reaction (approx. 85%). Yield: 43 g Intermediate 2: N-(2-{2-[(2,4-dichlorobenzyl)methylamino]acetyl}phenyl)acetamide 12.4 g (65.24 mmoi) of 2,4-dichlorobenzylmethylamine (Example 1, intermediate 1) were dissolved in 200 ml of dioxane. To this were added 19.96 g of the crude product of the above bromination, likewise dissolved in 200 ml of dioxane, and 45 ml of triethylamine. The mixture was stirred at room temperature overnight and then filtered. The filtrate was evaporated, and the residue was taken up in ethyl acetate and washed with saturated sodium hydrogen carbonate and sodium chloride solution, dried over sodium sulfate and concentrated by rotary evaporation. According to NMR, the crude product (20.4 g) was clean enough for the further reaction. Intermediates: N-(2-{2-[(2,4-dichlorobenzyl)methyIamino]-1-hydroxyethyl}-phenyl)acetamide 20 g of the crude product of the preceding stage (approx. 50 mmol) were dissolved in 200 ml of methanol and cooled to Intermediate 4: 1-(2-aminophenyl)-2-[(2,4-dichlorobenzyl)methylamino]ethanol 10 g of the crude product from the preceding stage were dissolved in 300 ml of methanol. 200 ml of concentrated hydrochloric acid were added and the mixture was stirred at 50°C for 10 hours. The mixture was allowed to cool and poured into water, and the pH was adjusted to 10-12 using 20% NaOH. The product was extracted with ethyl acetate, and the combined extracts were washed with sodium chloride solution, dried over sodium sulfate and evaporated. The crude product (9.9 g) contained a little sodium chloride, which did not, however, disrupt the further reaction. Intermediate 5: 2-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenylamine 9.9 g of the crude product from the preceding stage were dissolved in 350 ml of chloroform. With cooling in an ice bath, 123 ml of concentrated sulfuric acid were added dropwise. Stirring was carried out in the ice bath for 2 hours, then the mixture was gradually warmed to room temperature and finally heated to 50°C overnight. The cooled mixture was poured onto ice and made alkaline using sodium hydroxide solution (pH > 10). The organic phase was removed, the aqueous phase was extracted twice with methylene chloride, and the combined organic phases were washed with water and NaCI, dried over sodium sulfate and evaporated. Intermediate 6: N-[2-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-(2R,3S,4R,5R)-2,3,4,5,6-penta-0-acetylhexanamide 614 mg (2.0 mmol) of 2-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenylamine (intermediate 5) were dissolved in 20 ml of pyridine and admixed at 0°C with a solution of 1.5 equivalents of 2,3,4,5,6-penta-O-acetylgluconyl chloride in 10 ml of dichloromethane. The mixture was stirred at room temperature. Once the monitoring of the reaction indicated complete conversion, the mixture was concentrated and the residue taken up in dichloromethane. Washing was effected once with H20, once with saturated NaHC03 solution, twice with 1 N HCI and once more with H20, followed by drying over MgS04 and concentration. The crude product obtained in this way (1.27 g) was able to be used in the next reaction without further purification. 3: N-[2-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-(2R)3S,4R,5R)-2,3,4]5,6-pentahydroxyhexanamide; 1.27 g of the crude product from intermediate 6 were admixed in 30 ml of methanol at room temperature with 513 mg (9.5 mmol) of sodium methoxide. After 1 to 2 hours at room temperature, the pH was adjusted to about 7 using 1 N HCI and the solvent removed in vacuo. The residue was taken up in sat. NaHC03 solution and extracted twice with ethyl acetate. The combined organic phases were washed once more with H20, dried over MgS04 and concentrated. Chromatography on silica gel using a dichloromethane/methanol mixture afforded 313 mg of the title compound as a pale yellow solid. 3a: N-[2-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanamide hydrochloride 145.5 mg (0.3 mmol) of N-[2-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-2,3,4,5,6-pentahydroxygluconamide (example compound 3) were taken up in 75 ml of H20 and admixed at room temperature with 3.0 ml of 0.1 M HCI. The mixture was stirred for 15 minutes, filtered and freeze-dried to obtain 149 mg of the desired hydrochloride. Example 4: 4a; N-[(R)-3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yI)phenyl]-(2R,3S,4R15R)-2l3,4,5,6-pentahydroxyhexanamideand 4b: N-[(S)-3-(6,8-dichloro-2-me%M^ (2R)3S)4R)5R)-2I3,4,5,6-pentahydroxyhexanamide 2.u y ui me example uumpuunu ^ weie sepaiciieu UII a urmai pnase nuu uie iwu diastereomers. Preparative separation conditions for baseline separation: Chiral column: Chiralpak AD9 250 x 50 mm + Chiralpak AD2 250 x 50 mm Solvent: 2:1:1 heptane:ethanol:methanol Flow rate: 150 ml/min Analytical data on a chiral phase: Chiral column: Chiralpak ADH/40 250 x 4,6 Solvent: 2:1:1 heptane:ethanol:methanol Flow rate: 1 ml/min Temperature: 30 °C Retention time of diastereomer A: 4.5 minutes, Yield of diastereomer A: 988 mg; Retention time of diastereomer B: 7.5 minutes, Yield of diastereomer B: 942 mg. Example 5: N-[(R or SJ-S^.S^Iichloro^-methyl-I^.S^-tetrahydroisoquinolin^-yl)phenylH2R)3SI4R15R)-2,3f4)5l6-pentahydroxyhexanamide hydrochloride 300 mg (0.6 mmol) of N-[(R or S)-3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin^-yOphenylHZR.SS^R^R^^^.S^-pentahydroxyhexanamide (Example compound 4a or 4b; diastereomer B) were taken up in 20 ml of H2O and admixed at room temperature with 6.18 ml of 0.1 M HCI. The mixture is stirred for 15 minutes, filtered and freeze-dried to obtain 297 mg of the desired hydrochloride. Example 6: 1-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-3-(2-hydroxy-1-hydroxymethylethyl)urea Intermediate 1: 4-nitrophenyl [3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]carbamate hydrochloride 350 mg (1.1 mmol) of 3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenylamine (Example compound 2, intermediate 1) were dissolved in 17.5 ml of dichloromethane and admixed with stirring with 230 mg (1.1 mmol) of 4-nitrophenyl chloroformate. After 4.5 hours, a further 0.1 equivalent (23 mg) of 4-nitrophenyl chloroformate was added and the solution was stirred overnight. For workup, the resulting precipitate was filtered off and washed with dichloromethane. The crude product obtained in this way could be reacted further without further purification. 6: 1-[3-(6,8-dichloro«2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-3-(2-hydroxy-1-hydroxymethylethyl)urea 1.02 g (2.0 mmol) of 4-nitrophenyl [3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]carbamate hydrochloride (intermediate 1) were dissolved in 30 ml of abs. DMF and admixed at 0°C with a solution of 200.5 mg (2.2 mmol) of 2-amino-1,3-propanediol in 25 ml of abs. DMF. The mixture was stirred at room temperature for 3 hours. After standing overnight, the solvent was removed in vacuo and the residue partitioned between ethyl acetate and saturated NaHC03 solution. The organic phase was removed and the aqueous extracted twice more with ethyl acetate. The combined organic phases were washed with saturated NaCI solution, dried over Na2S04 and concentrated. Chromatography of the crude product obtained in this way on silica gel (dichloromethane/methanol mixture) afforded 500 mg of the desired urea. 6a: 1-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-3-(2-hydroxy-1 -hydroxymethylethyi)urea hydrochloride 200 mg of 1-[3-(6,8-dichloro-2-methyl-1,2)3J4-tetrahydroisoquinolin-4-yl)phenyl]-3-(2-hydroxy-1-hydroxymethylethyl)urea (Example compound 6) were dissolved in 40 ml of 0.1 M HCI, filtered and freeze-dried to obtain 194 mg of the desired hydrochloride. Example 7: 1-[3-(6,8-dichloro-2-methyM hydroxy-1,1-bishydroxymethylethyl)urea 1.02 g (2.0 mmol) of 4-nitrophenyl [3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]carbamate hydrochloride (intermediate 1, Example 6) were reacted with 2-amino-2-hydroxymethylpropane-1,3-diol in a similar manner to that described in Example 6. Similar workup afforded 395 mg of the title compound. 7a: 1-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-3-(2-hydroxy- 1.1 -bishydroxymethylethyl)urea hydrochloride A similar procedure to the method described in Example 6a starting from 200 mg of 1- [3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahy bishydroxymethylethyl)urea (Example compound 7) afforded 195 mg of the desired hydrochloride. Example 8: 1-[3-(6,8-dichloro-2-methyl-1 ,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-3-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)urea 1.02 g (2.0 mmol) of 4-nitrophenyl [3-(6,8-dichloro-2-methyl-1,2,3,4- tetrahydroisoquinolin~4-yl)phenyi]carbamate hydrochloride (intermediate 1, Example 6) were reacted with D-glucamine in a similar manner to'the way described in Example 6. Similar workup afforded 273 mg of the title compound. 8a: 1-[3-(6,8-dichloro-2-methyl-1T2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-3- ((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)urea hydrochloride A similar procedure to the method described in Example 6a starting from 200 mg of 1- [3-(6,8-dichloro-2-methyI-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-3-((^ 6-pentahydroxyhexyl)urea (Example compound 8) afforded 181 mg of the desired hydrochloride. Example 9: 1-[3-(6,8-dichloro-2-m^ ((4R,5S,6R)-2,4,5-trihydroxy-6-hydroxyrnethyltetrahydropyran-3-yl)urea 254 mg (0.5 mmol) of 4-nitrophenyl [3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]carbamate hydrochloride (intermediate 1, Example 6) were initially charged in 7 ml of abs. DMF and admixed at 0°C with a suspension of 119 mg (0.55 mol) of D-glucosamine hydrochloride in 5 ml of abs. DMF. A similar procedure to the method described in Example 6 afforded, after chromatography on silica gel, 87 mg of the title compound. Example 10: {N-[3-(6,8-dichloro-2-methyl-1 ^.S^-tetrahydroisoquinolin^-yOphenylJ-N'-(1-sulfo-2-ethyl)}urea hydrochloride 1.02 g (2.0 mmol) of 4-nitrophenyl [3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]carbamate hydrochloride (intermediate 1, Example 6) were admixed in 30 ml of abs. DMF at 0°C with 275 mg (2.2 mmol) of 2-aminoethanesulfonic acid, and also 0.83 ml (6.0 mmol) of triethylamine and stirred at room temperature for 2 hours. After standing overnight, the liquid was filtered off from the precipitate which had formed and was concentrated in vacuo. The residue was taken up in saturated NaHCC>3 solution, filtered and neutralized with 1 N HCI, and a solid precipitated out. Filtering off and drying afforded 356 mg of the title compound as a crude product. The mother liquor was freeze-dried and the residue triturated with dichloromethane. The insoluble residue (634 mg) was combined with the precipitate (356 mg) which had already been obtained and chromatographed on silica gel. After a further purification on a preparative HPLC, the product fractions were combined and freeze-dried. The product obtained in this way was dissolved in 1 N HCI and freeze-dried once again to obtain the desired hydrochloride. Repeated dissolution in H20 and further freeze-drying afforded 271 mg of the title compound. Example 11: {N-[3-(6,8-dichloro-2-methyl-1 ,2,3,4-tetrahydroisoquinoIin-4-yI)phenyl]-N'-(ethyl-2-trimethylammonium)}urea chloride hydrochloride 1.02 g (2.0 mmol) of 4-nitrophenyl [3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]carbamate hydrochloride (intermediate 1, Example 6) were dissolved in 30 ml of abs. DMF and admixed at 0°C with a solution of 333 mg (1.9 mmol) of 2-aminoethyltrimethylammonium chloride hydrochloride in 5 ml of DMF. After addition of 0.277 ml (2.0 mmol) of triethylamine, the mixture was stirred at room temperature for 4 hours. After standing overnight, the mixture was filtered and concentrated in vacuo. The residue was taken up in H20 and freeze-dried to obtain 1.77 g of crude product. Purification on a preparative HPLC afforded the desired product which could be converted to the title compound by dissolution in 1 N HCI and freeze-drying. After repeated dissolution in H20 and further freeze-drying, 544 mg of the desired hydrochloride were obtained. Example 12: {N-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-N'-(1-carboxy-3-hydroxy-2S-propyl)}urea Intermediate 1: 3-acetylbenzoic acid The title compound was prepared in a manner known to those skilled in the art from 3- acetylbenzonitrile by hydrolyzing the nitrile group. Intermediate 2: ethyl 3-acetylbenzoate The title compound was prepared in a manner known to those skilled in the art by acid-catalyzed esterification of 3-acetylbenzoic acid (intermediate 1). Intermediate 3: ethyl 3-(2-bromoacetyl)benzoate The title compound is synthesized from ethyl 3-acetylbenzoate (intermediate 2) in a similar manner to the method described in Example 1, intermediate 2. Intermediate 4: ethyl 3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4- yl)benzoate In a similar manner to the synthetic route described under Example 1, the process was continued starting from ethyl 3-(2-bromoacetyl)benzoate (intermediate 3) and 2,4- dichlorobenzylmethylamine (Example 1, intermediate 1) to obtain ethyl 3-(6,8-dichloro- 2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)benzoate after alkylation reaction, reduction and ring closure reaction. Intermediate 5: 3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)benzoic acid 3.3 g of ethyl 3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)benzoate ► (intermediate 4) were dissolved in 60 ml of methanol and admixed with 60 ml of 2 N KOH. After two hours at 50°C, the mixture was concentrated in vacuo and the residue partitioned between water and ether. The water phase was adjusted to a pH of approx. freeze-dried. Afterwards, dissolution in H2O was repeated and was followed by further freeze-drying to obtain 170 mg of the title compound. Example 20: {N-lS^e.S-dichloro^-methyl-l^^^-tetrahydroisoquinolin-^CR or S)-yl)phenyl]-N'-(1-carboxy-4-aminocarboxy-2S-butyl)}urea hydrochloride Intermediate 1: 1 a: (R)-3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenylamine and 1 b: (S)-3-(6,8-dichloro-2-methyl-1 ,2,3,4-tetrahydroisoquinolin-4-yl)phenylamine 10 g of 3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenylamine (Example 2, intermediate 1) were separated into the enantiomers on a chiral phase. Preparative separation conditions in baseline separation: Chiral column: Chiralpak AD10 50 x 10 cm, base-preconditioned; Solvent: 45:4:1 acetonitrile:ethanol:methanol Flow rate: 300 ml/min Analytical data on a chiral phase: Chiral column: Chiralpak ADH/33 250 x 4.6, base-preconditioned; Solvent: 45:4:1 acetonitrile:ethanol:methanol Flow rate: 1 ml/min Temperature: 30°C Retention time of enantiomer A: 4.498 minutes, Yield of enantiomer A: 4.0 g; Retention time of enantiomer B: 5.480 minutes, 29: (S)-2-[3-((S)-1 -carboxy-2.hydroxyethylcarbamoyl)-5-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin«4-yl)benzoylamino]-3-hydroxypropionicacid hydrochloride 200 mg of intermediate 1 were stirred in 5 ml of trifluoroacetic acid at room temperature for 1 hour. Subsequently, the solvent was removed in vacuo, and the residue was triturated with ether and filtered off with suction. The trifluoroacetate obtained in this way was dissolved in dilute HCI and freeze-dried to obtain 109 mg of the title compound. Example 30: N-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-(S)-2-amino-5-guanidinopentanamide hydrochloride Intermediate 1: N-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-2S-tert-butoxycarbonylamino-5-(N',N"-di-tert-butoxycarbonyl)- guanidinopentanamide 570 mg (1.2 mmol) of (S)-5-(N\N"-di-tert-butoxycarbonylguanidino)-2-tert-butoxycarbonylaminopentanoic acid were initially charged in 10 ml of DMF and 405 mg (4.0 mmol) of triethylamine were added. After cooling to 0°C, 406 mg (3.0 mmol) of HOBt, 379 mg (3.0 mmol) of DIC and 61 mg (0.5 mmol) of DMAP were added. Afterwards, the mixture was admixed at 0°C with a solution of 307 mg (1.0 mmol) of 3-(6,8-dichloro-2-methyl-1 ,2,3,4-tetrahydroisoquinolin-4-yl)phenylamine (Example 2, intermediate 1) in 6 ml of DMF and stirred at room temperature. For workup, the solvent was removed in vacuo, and the residue was taken up in ethyl acetate and washed with saturated NaHC03 solution. The organic phase was removed and the aqueous extracted once more with ethyl acetate. The combined organic phases were washed once with 2 N HCI and once with H20, dried over MgS04 and concentrated by rotary evaporation. After subsequent chromatography on silica gel, 237 mg of the title compound were obtained. 30: N-[3-(6,8-dichloro-2-methy^^ 5-guanidinopentanamide hydrochloride 237 mg of intermediate 1 were dissolved in 5 ml of dichloromethane and admixed at 0°C with 1 ml of trifluoroacetic acid. The mixture was allowed to warm to room temperature and was stirred for 24 hours. Afterwards, the mixture was freed of solvents and codistilled once with toluene. The product obtained in this way was dissolved in 25 ml of 0.1 N HCI, filtered and freeze-dried. Repeated dissolution in H20 and subsequent freeze-drying afforded 162 mg of the title compound. Example 31: N-[4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-(S)-2-amino-5-guanidinopentanamide trifluoroacetate Starting from 4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenylamine (Example 1, intermediates) and (S)-5-(N')N"-di-tert-butoxycarbonylguanidino)-2-tert-butoxycarbonylaminopentanoic acid, a similar procedure to the method described in Example 30 with subsequent treatment with trifluoroacetic acid afforded the title compound as the trifluoroacetate. Example 32: (S)-2-amino-N-[3-(6,8HJichloro-2-methyl-1 ^^^-tetrahydroisoquinolin^-yl)phenyl]-3-(1 H-imidazol-4-yl)propionamide trifluoroacetate The title compound was prepared in a similar manner to the procedure described in Example 30 starting from S-Ce^-dichloro^-methyl-I^.S^-tetrahydroisoquinolin-^ yl)phenylamine (Example 2, intermediate 1) and tert-butyl 4-((S)-2-tert-butoxycarbonylamino-2-carboxyethyl)imidazole-1 -carboxyiate with subsequent treatment with trifluoroacetic acid. Example 33: (S)-2-amino-N-[4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-3-(1 H-imidazol-4-yI)propanamide trifluoroacetate The title compound was prepared in a similar manner to the procedure described in Example 30 starting from 4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenylamine (Example 1, intermediate 6) and tert-butyl 4-((S)-2-tert-butoxycarbonylamino-2-carboxyethyl)imidazole-1-carboxyiate with subsequent treatment with trifluoroacetic acid. Example 34: Ethyl {S-^e.S-dichloro^-methyl-I^.S^-tetrahydroisoquinolin^-yl)-phenyl]ureido} acetate hydrochloride 4-(6,8-Dichloro-2-methyl-1 ,2,3,4-tetrahydroisoquinolin-4-yl)phenylamine (95 mg, example 1, intermediate 6) was dissolved in acetonitrile (2 ml) and ethyl isocyanatoacetate (30 mg) was added dropwise with stirring. After four hours, the solution was concentrated and the residue purified by means of preparative HPLC. The product-containing fractions were combined, the acetonitrile was removed on a rotary evaporator, and the aqueous residue was neutralized with potassium carbonate and extracted three times with ethyl acetate. Drying over magnesium sulfate was followed by drying. The residue was taken up with aqueous hydrochloric acid and freeze-dried. 107 mg of the desired compound were obtained. Example 35: Ethyl {S-tS^e.S-dichloro^-methyl-I^.S^-tetrahydroisoquinolin^-yl)-phenyl]ureido} acetate hydrochloride In a similar manner to example 34, 3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydro-isoquinolin-4-yl)phenylamine (example 2, intermediate 1) and ethyl isocyanatoacetate were reacted. Example 36: Ethyl {3-[2-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)-phenyl]ureido} acetate hydrochloride Example 42: Ethyl {3-[4-(6I8-dichloro-2-methyl-1,2)3,4-tetrahydroisoquinolin-4(R or S)-yl)phenyl]ureido} acetate Intermediate 1: (R)-4-(6t8-dichloro-2«methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenylamine and (S^^e^-dichloro^-methyl-l^^^-tetrahydroisoquinolin^-yOphenylamine 4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)-phenylamine (example 1, intermediate 6) was separated into the enantiomers on a chiral phase. Preparative separation conditions: Chiral column: Chiralpak AD10 35 x 10 cm Solvent: MeOH/0.1% DEA Flow rate: 300 ml/min Analytical data on a chiral phase: Chiral column: Chiralpak ADH 250 x 4.6 mm , Solvent: MeOH/0.1%DEA Flow rate: 1 ml/min Temperature: 30°C Retention time of enantiomer A: 4.8 min Retention time of enantiomer B: 7.6 min In a similar manner to example 40, 4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydro-isoquinolin-4(R or S)-yI)phenylamine (enantiomer B) and ethyl isocyanatoacetate were reacted. Example 43: {3"[4"(6,8-Dichloro-2«methyl-1,2,3,4-tetrahydroisoquinolin-4(R or S)-yl)-phenyl]ureido} acetic acid, trifluoroacetic acid salt In a similar manner to example 4, ethyl {3-[4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4(R or S)-yl)phenyl]ureido} acetate hydrochloride (example 42) was hydrolyzed, except that ethanol served as the solvent and aqueous sodium hydroxide solution as the base. Example 44: {3-[2-(6,8-Dichloro-2-methyM ,2,3,4-tetrahydroisoquinolin-4(R or S)-yl)-phenyi]ureido} acetic acid, trifluoroacetic acid salt TFA |T^j O a Ethyl {3-[2'(6,8-dichloro-2-methyl-1r2f3,4-tetrahydroisoquinolin-4(R or S)-yl)phenyl]ureido} acetate hydrochloride (430 mg, example 41) was initially charged in water (35 ml) and admixed with 10% hydrochloric acid with stirring. After 3 hours under reflux, the mixture was hydrolyzed. The solvent was removed and the residue purified by means of preparative HPLC. The product-containing fractions were combined, and the solvent removed on a rotary evaporator. The residue was further purified using silica gel (1:1 ethyl acetate/methanol), the product-containing fractions were combined, the solvent was removed on a rotary evaporator and the residue was freeze-dried. 45 mg of the desired compound were obtained. Example 45: {S-^e.S-Dichloro^-methyl-I^.S^-tetrahydroisoquinolin^CR or S)-yl)-phenyl]ureido} acetic acid, trifluoroacetic acid salt In a similar manner to example 4, ethyl {3-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4(R or S)-yl)phenyl]ureido} acetate hydrochloride (example 40) was hydrolyzed, except that the acetonitrile solvent was dispensed with. Example 46: 2-Methoxyethyl [4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4(R or S)~yl)phenyl]carbamate 4-(6,8-Dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4(R or S)-yl)phenylamine (70 mg, example 20, intermediate 1, enantiomer B) was dissolved in methylene chloride (4.5 ml) and a solution of 2-methoxyethyl chloroformate (39 mg) in methylene chloride (0.5 ml) was slowly added dropwise with stirring. After leaving to stand overnight, the solvent was removed and the residue purified by means of preparative HPLC. The product-containing fractions were combined, the acetonitrile removed on a rotary evaporator, and the residue admixed with hydrochloric acid and freeze-dried. 80 mg of the desired compound were obtained. Example 47: 2-Methoxyethyl [3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4(R or S)-yl)phenyl]carbamate In a similar manner to example 13, 3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydro-isoquinolin-4-yl)phenylamine (example 2, intermediate 1) was reacted with 2-methoxy-ethyl chloroformate. However, chromatography could be dispensed with. Conditions Prep. HPLC: Unless stated otherwise, the preparative HPLC was carried out under the following conditions: stationary phase: Merck Purospher RP18 (10uM) 250 x 25 mm mobile phase: 90% H2O (0.05% TFA)-> 90% acetonitrile; 40 min; 25 ml/min LCMS methods: Method A: Stationary phase: YMC, J'sphere ODS, H80 20 x 2 4 \xMobile phase: 0 min, 90% H20 (0.05% TFA); 2.5 min, 95% ACN; 3.3 min, 95% ACN; 3.35 min, 90% H20; 1 ml/min; 30°C. Method B: Stationary phase: Merck Purosphere 3 y. 2 x 55 mm; Mobile phase: 0 min, 95% H20 (0.05% TFA); 4 min, 95% ACN; 5.5 min, 95% ACN; 6.5 min, 95% H20; 0.5 ml/min; 30°C. Method C: Stationary phase: Merck Purosphere 5 ^ 2 x 55 mm; Mobile phase: 0 min, 95% H20 (0.05% TFA); 3 min, 95% ACN; 4.5 min, 95% ACN; 5.5 min, 95% H20; 0.5 ml/min; 30°C. Method D: Stationary phase: YMC, J'sphere ODS, H80 20 x 2 4 \i; Mobile phase: 0 min, 90% H20 (0.05% TFA); 1.9 min, 95% ACN; 2.4 min, 95% ACN; 2.45 min, 90% H20; 1 ml/min; 30°C. Method E: Stationary phase: Merck Purosphere 5 \x 2 x 55 mm; Mobile phase: 0 min, 95% H20 (0.05% TFA); 3.5 min, 95% ACN; 4.5 min, 95% ACN; 5.5 min, 95% H20; 0.5 ml/min; 30°C. Method F: Stationary phase: YMC J'sphere ODS H80 20 x 2.1 mm Mobile phase: 90% H2O (0.05% TFA)-> 95% acetonitrile; 1.9 min; 95% acetonitrile; 0.5 min ->• 10% acetonitrile; 0.05 min; 1 ml/min. Method G: Stationary phase: YMC J'sphere ODS H80 20 x 2.1 mm Mobile phase: 96% H2O (0.05% TFA)-> 95% acetonitrile; 2.0 min; 95% acetonitrile; 0.4 min -> 4% acetonitrile; 0.05 min; 1 ml/min. Pharmacological data: Test description: This test determines the recovery of the intracellular pH (pHj) after acidification, and this recovery occurs in the case of functional NHE even under bicarbonate-free conditions. To this end, the pHj was determined using the pH-sensitive fluorescent dye BCECF (Calbiochem, the BCECF-AM precursor was used). The cells were initially loaded with BCECF. The BCECF fluorescence was determined in a Ratio Fluorescence Spectrometer (Photon Technology International, South Brunswick, N J., USA) at excitation wavelengths of 505 and 440 nm and an emission wavelength of 535 nm and converted to the pHj by means of calibration curves. The cells had already been incubated in NH4CI buffer (pH 7.4) in the course of the BCECF loading (NH4CI buffer: 115 mM NaCI, 20 mM NH4CI, 5 mM KCI, 1 mM CaCfc, 1 mM MgS04, 20 mM Hepes, 5 mM glucose, 1 mg/ml BSA; a pH of 7.4 was established using 1 M NaOH). The intracellular acidification was induced by adding 975 \i\ of an NH4CI-free buffer (see below) to 25 \i\ aliquots of the cells incubated in NH4CI buffer. The subsequent rate of the pH recovery was registered at 2 minutes for NHE1, at 5 minutes for NHE2 and at three minutes for NHE3. For the calculation of the inhibitory potency of the tested substances, the cells were initially investigated in buffers in which complete or absolutely no pH recovery took place. For complete pH recovery (100%), the cells were incubated in Na+-containing buffer (133.8 mM NaCI, 4.7 mM KCI, 1.25 mM CaCI2, 1.25 mM MgCI2, 0.97 mM Na2HP04, 0.23 mM NaH2P04, 5 mM Hepes, 5 mM glucose, a pH of 7.0 was established using 1 M NaOH). For the determination of the 0% value, the cells were incubated in an Na+-free buffer (133.8 mM choline chloride, 4.7 mM KCI, 1.25 mM CaCI2j 1.25 mM MgCfc. 0.97 mM K2HP04, 0.23 mM KH2P04, 5 mM Hepes, 5 mM glucose, a pH of 7.0 was established using 1 M NaOH). The substances to be tested were made up in the Na+-containing buffer. The recovery of the intracellular pH at each tested concentration of a substance was expressed in percent of the maximum recovery. The percentages of the pH recovery were used to calculate the IC50 value of the particular substance for the individual NHE subtypes by means of the program Sigma-Plot. The inhibitory data of some example compounds were shown by way of example in Table 2. Claims: where: R1,R2, R3 and R4 are each independently H, F, CI, Br, I, CN, NO2, OH, alky! having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated, cycloalkyl having 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated, O-alkyl having 1,2,3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated, Ok-(CH2)1-phenyl, heteroaryl having 1, 2, 3 or 4 nitrogen atoms or 1 oxygen atom or 1 sulfur atom, Oh-SOj-R10, NR14R15, CONR16R17, COOR18 orOCOR18; k is 0 or 1; I is0, 1,2, 3 or 4; h is0orl; j is 0, 1 or 2; R10 is alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated, OH, O-alkyl having 1,2,3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated or NR11R12; R11 and R12 are each independently hydrogen, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated and one or more CH2 groups may be replaced by0, NR13, CO or CS, R13 is H or alkyl having 1,2,3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated, or R11 and R12 together with the nitrogen atom which bonds them together may form a 5- or 6-membered ring; R14 and R15 are each independently H, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated and one or more CH2 groups may be replaced by O, CO, CS or NR19, or R14 and R15 together with the nitrogen atom which bonds them together may form a 5- or 6-membered ring; R16andR17 are each independently H, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated and one or more CH2 groups may be replaced by O, CO, CS or NR19, or R16 and R17 together with the nitrogen atom which bonds them together may form a 5- or 6-membered ring; R19 is H or alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated; R18 is H or alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated; R5 is H, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated, cycloalkyl having 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated, COR20 or SO2R2O; R20 is H or alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may befluorinated; R6 is H, OH, F, CI, Br, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated, cycloalkyl having 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated, O-alkyl having 1,2,3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated, or O-acyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated; R7, R8 and R9 are each independently H, F, CI, Br, I, OH, alkyl having 1,2,3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated, cycloalkyl having 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated, O-alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated, Ov- SOw-R47, COR47, COOR60, NR51R52 or a -L-G group; v isOorl; w is 2 or 3; R47 is H, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated or NR48R49; R48 and R49 are each independently H, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated and one or more CH2 groups may be replaced by O, CO, CS or NR50, R50 is H or alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms of which some or all may be fluorinated; or R48 and R49 together with the nitrogen atom which bonds them together form a 5, 6, 7 or 8-membered ring; R60 is H, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms of which some or ail may be fluorinated; R51 and R52 are each independently H, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated, acyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated and one or more CH2 groups may be replaced by O or NR53, R53 is H or alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms of which some or all may be fluorinated; or R51 and R52 together with the nitrogen atom which bonds them together form a 5, 6, 7 or 8-membered ring; L is -CH2-, -0-, -NR30-, -OCO-, -NR30CO-, -NR30CS-, -NR30SO2-, -CONR30-, -COO-, -CSNR30-, -SO2NR30-, -NR30CONR31-, - NR30COO-, -NR30CSNR31- or -NR30SO2NR31-; R30 and R31 are each independently H, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated or cycloalkyl having 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated; G is a Ca(OR32)xH2a+1-x group where one or more CH2 groups may be replaced by O or NR33, Cb(OR32)yH2b-1-y where one or more CH2 groups may be replaced by O or NR33, CcH2c+1 where two or more CH2 groups are replaced by O or NR33, -(CH2)z-COOR34,-(CH2)z -S03R34, -(CH2)Z -N+R35R36R37 where one or more hydrogen atoms of the -(CH2)Z units may be replaced by OR32 groups, -CR38R39-COOR40 or -CR38R39NR41R42, a is 2, 3, 4, 5, 6, 7 or 8; x is 2, 3,4,5,6, 7 or 8; R32 is H, alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms of which some or all may be fluorinated or acyl having 1, 2, 3, 4, 5 or 6 carbon atoms of which some or all may be fluorinated; R33 is H or alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms of which some or all may be fluorinated; b is 3, 4, 5, 6 or 7; y is 2, 3, 4, 5, 6 or 7; c is 3, 4, 5,6, 7 or 8; z is0, 1, 2, 3 or 4; R34, R35, R36 and R37 are each independently H or alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms of which some or all may be fluorinated; R38 is -(CH2)n -Y; n is 0, 1, 2, 3 or 4; Y is H, alkyl having 1,2,3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated and one or more CH2 groups may be replaced by O, S or NR43, or is -COOR44, -CONR45R46, -NHC(NH)NH2, phenyl or heteroaryl, and the phenyl and heteroaryl radicals may be substituted by up to three substituents selected from the group of CH3, CF3, OH, OCH3 and NH2; R43, R44, R45 and R46 are each independently H or alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms of which some or all may be fluorinated; R39 is H or alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated; R40 is H or alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated; R41 and R42 are each independently H, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated or acyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms of which some or all may be fluorinated; in which at least one of the R7, R8 or R9 radicals has to be defined by the -L-G group, and also its pharmaceuticallyacceptable salts and trifluoroacetates. 2. A compound of the formula I as claimed in claim 1 where R1, R2, R3andR4, are each independently H, F, CI, Br, I, CN, NO2, OH, alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated, cycloalkyl having 3, 4, 5 or 6 carbon atoms of which some or all may be fluorinated, O-alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated, O-phenyl, SO2R10, NR14R15, CONR16R17, COOR18 or OCOR18; R10 is alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated, OH or NR11R12; R11 andR12 are each independently hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated, or acyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated, or R11 and R12 together with the nitrogen atom which bonds them together form a 5- or 6-membered ring, from the group of 1-pyrrolyl, 1-piperidinyl, 1-piperazinyl, 1-N-methylpiperazinyl and 4-morpholinyl; R14 and R15 are each independently H, alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated or acyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated, or R14andR15 together with the nitrogen atom which bonds them together form a 5- or 6-membered ring, from the group of 1-pyrrolyl, 1-piperidinyl, 1-piperazinyl, 1-N-methylpiperazinyl and 4-morpholinyl; R16andR17 are each independently H or alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated, or R16andR17 together with the nitrogen atom which bonds them together form a 5- or 6-membered ring, from the group of 1-pyrrolyl, 1-piperidinyl, 1-piperazinyl, 1-N-methylpiperazinyl and 4-morpholinyl; R18 is H or alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated; R5 is H, alkyl having 1, 2, 3 or 4 carbon atoms of which some or all maybe fluorinated, or cycloalkyl having 3, 4, 5 or 6 carbon atoms of which some or all may be fluorinated; R6 is H, OH, F, CI, Br, alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated, cycloalkyl having 3, 4, 5 or 6 carbon atoms of which some or all may be fluorinated, O-alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated, or O-acyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated; R7, R8 and R9 are each independently H, F, CI, Br, I, OH, alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated, cycloalkyl having 3, 4, 5 or 6 carbon atoms of which some or all may be fluorinated, O-alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated, OV-SOW-R47, COR47, COOR60, NR51R52 or a -L-G group; v is 0 or 1; w is 2 or 3; R47 is H, alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated, or NR48R49; R48 and R49 are each independently H, alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated, acyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated, or R48 and R49 together with the nitrogen atom which bonds them together form a 5- or 6-membered ring, from the group of 1-pyrrolyl, 1-piperidinyl, 1-piperazinyl, 1-N-methylpiperazinyl and 4-morpholinyl; R60 is H, alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated; R51 and R52 are each independently H, alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated, acyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated, or R51 and R52 together with the nitrogen atom which bonds them together form a 5- or 6-membered ring, from the group of 1-pyrrolyl, 1-piperidinyl, 1-piperazinyl, 1-N-methylpiperazinyl and 4-morpholinyl; L is -CH2~, -0-, -NR30-, -OCO-, -NR30CO-, -NR30CS-, -NR30SO2-, -CONR30-, -COO-, -CSNR30-, -SO2NR30-, -NR30CONR31-, -NR30COO-, -NR30CSNR31- or-NR30SO2NR31-; where R30 and R31 are each independently H, alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated or cycloalkyl having 3, 4, 5 or 6 carbon atoms of which some or all may be fluorinated; G is a Ca(OR32)xH2a+1-x group where one or more CH2 groups may be replaced by O or NR33, Cfc>(OR32)yH2b-1-y where one or more CH2 groups may be replaced by O or NR33, CcH2c+1 where two or more CH2 groups are replaced by O or NR33, -(CH2)z-COOR34, -(CH2)2 -SO3R34, -(CH2)Z-N+R35R36R37 where one or more hydrogen atoms of the -(CH2)Z units may be replaced by OR32 groups, -CR38R39-COOR40 or -CR38R39NR41R42; a is 2, 3,4, 5,6, 7 or 8; x is 2, 3,4, 5,6, 7 or 8; R32 is H, alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated or acyl having 1,2,3 or 4 carbon atoms of which some or all may be fluorinated; R33 is H or alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated; b is 3, 4, 5, 6 or 7; y is 2, 3,4, 5, 6 or 7; c is 3, 4, 5, 6, 7 or 8; z is 0, 1, 2, 3 or 4; R34, R35, R36 and R37 are each independently H or alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated; R38 is -(CH2)n -Y; n is 0, 1,2, 3 or 4; Y is H, alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated and one or more CH2 groups may be replaced by O, S or NR43, or is COOR44, CONR45R46, NHC(NH)NH2, phenyl or heteroaryl, and the phenyl and heteroaryl radicals may be substituted by up to three substituents selected from the group of CH3, CF3, OH, OCH3 and NH2; R43, R44, R45 and R46 are each independently H or alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may befluorinated; R39 is H or alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated; R40 is H or alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated; R41 and R42 are each independently H, alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated, or acyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated; in which at least one of the R7, R8 or R9 radicals has to be defined by the -L-G group, and also its pharmaceuticallyacceptable salts and trifluoroacetates. 3. A compound of the formula I as claimed in claim 1 and/or 2 where R1, R2, R3andR4, are each independently H, F, CI, Br, CN, NO2, OH, CH3, CH2CH3, CF3, CH2CF3, OCH3, OCH2CH3, OCF3, OCH2CF3, SO2R10, NR14R15, CONR16R17, COOR18 or OCOR18, R10 is CH3, CH2CH3, CF3, CH2CF3, OH, NR11R12, R11 and R12 are each independently H, CH3, CH2CH3, CF3, CH2CF3, COCH3, COCH2CH3, COCF3 or COCH2CF3, or R11 and R12 together with the nitrogen atom which bonds them together form a 5- or 6-membered ring from the group of 1-pyrrolyl, 1-piperidinyl, 1-piperazinyl, 1-N-methylpiperazinyl and 4-morpholinyl; R14andR15 are each independently H, CH3, CH2CH3, CF3, CH2CF3, COCH3, COCH2CH3, COCF3 or COCH2CF3, or R14andR15 together with the nitrogen atom which bonds them together form a 5- or 6-membered ring from the group of 1-pyrrolyl, 1-piperidinyl, 1-piperazinyl, 1-N-methylpiperazinyl and 4-morpholinyl; R16andR17 are each independently H, CH3, CH2CH3, CF3 or CH2CF3, or R16andR17 together with the nitrogen atom which bonds them together form a 5- or 6-membered ring from the group of 1-pyrrolyl, 1-piperidinyl, 1-piperazinyl, 1-N-methylpiperazinyl and 4-morpholinyl; R18 is H, CH3, CH2CH3, CF3 or CH2CF3; R5 is H, CH3, CH2CH3, CF3 or CH2CF3; R6 is H, OH, CH3, CH2CH3, CF3, CH2CF3, OCH3, OCH2CH3, OCF3, OCH2CF3, OCOCH3, OCOCH2CH3, OCOCF3or OCOCH2CF3; R7, R8 and R9 are each independently H, F, CI, Br, I, OH, CH3, CH2CH3, CF3, CH2CF3, OCH3, OCH2CH3, OCF3, OCH2CF3, S02R47, SO3R6O, COR47, COOR60, NR51R52 or a -L-G group; R47 is H, CH3, CH2CH3, CF3, CH2CF3 or NR48R49; R48 and R49 are each independently H, CH3, CH2CH3, CF3, CH2CF3, COCH3, COCH2CH3, COCF3 or COCH2CF3, or R48 and R49 together with the nitrogen atom which bonds them together form a 5- or 6-membered ring from the group of 1-pyrrolyl, 1-piperidinyl, 1-piperazinyl, 1-N-methylpiperazinyl and 4-morpholinyl; R60 is H, CH3, CH2CH3, CF3, CH2CF3; R51 and R52 are each independently H, CH3, CH2CH3, CF3, CH2CF3, COCH3, COCH2CH3, COCF3 or COCH2CF3, or R51 and R52 together with the nitrogen atom which bonds them together form a 5- or 6-membered ring from the group of 1-pyrrolyl, 1-piperidinyl, 1-piperazinyl, 1-N-methylpiperazinyl and 4-morpholinyl; L is -CH2-, -0-, -NR30-, -OCO-, -NR30CO-, -NR30CS-, -NR30SO2-, -CONR30-, -COO-, -CSNR30-, -SO2NR30-, -NR30CONR31-, - NR30COO-, -NR30CSNR31- or-NR30SC>2NR31-; R30 and R31 are each independently H, CH3, CH2CH3, CF3 or CH2CF3; G is a Ca(OR32)xH2a+l-x group where one or more CH2 groups may be replaced by O or NR33, Cb(OR32)yH2b-1-y where one or more CH2 groups may be replaced by O or NR33, CCH2C+1 where two or more CH2 groups are replaced by O or NR33, -(CH2)z-COOR34, -(CH2)Z -S03R34, -(CH2)Z -N+R35R36R37 where 1 or 2 hydrogen atoms of the -(CH2)z units may be replaced by OR32 groups, -CR38R39-COOR40 or -CR38R39NR41R42; a is 2, 3, 4, 5,6, 7 or 8; x is 2, 3, 4, 5, 6, 7 or 8; R32 is H, CH3, CH2CH3, CF3, CH2CF3, COCH3, COCH2CH3, COCF3 or COCH2CF3; R33 is H, CH3, CH2CH3, CF3 or CH2CF3; b is 3, 4, 5, 6 or 7; y is 2, 3, 4, 5, 6 or 7; c is 3, 4, 5, 6, 7 or 8; z is 1 or 2; R34, R35, R36 and R37 are each independently H, CH3, CH2CH3, CF3 or CH2CF3; R38 is -(CH2)n -Y; n is 0, 1, 2, 3 or 4; Y is H, alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated and one or more CH2 groups may be replaced by O, S or NR43, or is COOR44, CONR45R46, NHC(NH)NH2, phenyl or heteroaryl, and the phenyl and heteroaryl radicals may be substituted by up to 3 substituents selected from the group of CH3, CF3, OH, OCH3 or NH2; R43, R44, R45 and R46 are each independently H, CH3, CH2CH3, CF3 or CH2CF3; R39 is H, CH3, CH2CH3, CF3 or CH2CF3; R40 is H, CH3, CH2CH3, CF3 or CH2CF3; R41 and R42 are each independently H, CH3, CH2CH3, CF3, CH2CF3, COCH3, COCH2CH3, COCF3 or COCH2CF3; in which at least one of the R7, R8 or R9 radicals has to be defined by the -L-G group, and also its pharmaceuticallyacceptable salts and trifluoroacetates. 4. A compound of the formula I as claimed in one or more of claims 1 to 3 where R1.R2, R3andR4, are each independently H, F, CI, Br, CN, NO2, OH, CH3, CH2CH3, CF3, CH2CF3, OCH3, OCH2CH3, OCF3, OCH2CF3, SO2R10, NR14R15, CONR16R17, COOR18 or OCOR18; R10 is CH3, CH2CH3, CF3, CH2CF3, OH or NR11R12; R11 andR12 are each independently H, CH3, CH2CH3, CF3, CH2CF3, COCH3, COCH2CH3, COCF3 or COCH2CF3; R14andR15 are each independently H, CH3, CH2CH3, CF3, CH2CF3, COCH3, COCH2CH3, COCF3 or COCH2CF3; R16andR17 are each independently H, CH3, CH2CH3, CF3 or CH2CF3; R18 is H, CH3, CH2CH3,.CF3orCH2CF3; R5 is CH3; R6 is H; R7, R8 and R9 are each independently H, F, CI, Br, I, OH, CH3, CH2CH3, CF3, CH2CF3, OCH3, OCH2CH3, OCF3, OCH2CF3, S02R47, SO3R6O, COR47, COOR60, NR51R52 or a -L-G group; R47 is H, CH3, CH2CH3, CF3, CH2CF3 or NR48R49; R48 and R49 are each independently H, CH3, CH2CH3, CF3, CH2CF3, COCH3, COCH2CH3, COCF3 or COCH2CF3, or R48 and R49 together with the nitrogen atom which bonds them together form a 5- or 6-membered ring from the group of 1-pyrrolyl, 1-piperidinyl, 1-piperazinyl, 1-N-methylpiperazinyl and 4-morpholinyl; R60 is H, CH3, CH2CH3, CF3, CH2CF3; R51 and R52 are each independently H, CH3, CH2CH3, CF3, CH2CF3, COCH3, COCH2CH3, COCF3 or COCH2CF3 or R51 and R52 together with the nitrogen atom which bonds them together form a 5- or 6-membered ring from the group of 1-pyrrolyl, 1-piperidinyl, 1-piperazinyl, 1-N-methylpiperazinyl and 4-morpholinyl; L is -CH2-, -0-, -NR30-, -OCO-, -NR30CO-, -NR30CS-, -NR30SO2-, -CONR30-, -COO-, -CSNR30-, -SO2NR30-, -NR30CONR31-, -NR30COO-, -NR30CSNR31- or -NR30SO2NR31-; R30 and R31 are each independently H, CH3, CH2CH3, CF3 or CH2CF3; G is a group Ca(OR32)xH2a+1-x where one or more CH2 groups may be replaced by O or NR33, Cb(OR32)yH2b-1-y where one or more CH2 groups may be replaced by O or NR33, CcH2c+1 where two or more CH2 groups are replaced by O or NR33, -(CH2)z-COOR34, -(CH2)2 -SO3R34, -(CH2)Z -N+R35R36R37 where 1 or 2 hydrogen atoms of the -(CH2)Z units may be replaced by OR32 groups, -CR38R39-COOR40 or -CR38R39NR41R42; a is 2, 3, 4, 5, 6, 7 or 8; x is 2, 3, 4, 5, 6, 7 or 8; R32 is H, CH3, CH2CH3, CF3, CH2CF3, COCH3, COCH2CH3, COCF3 or COCH2CF3; R33 is H, CH3, CH2CH3, CF3 or CH2CF3; b is 3, 4, 5, 6 or 7; y is 2, 3, 4, 5, 6 or 7; c is 3, 4, 5, 6, 7 or 8; z is 1 or 2; R34, R35, R36 and R37 are each independently H, CH3, CH2CH3, CF3 or CH2CF3; R38 is -(CH2)n -Y; n 0,1,2, 3 or 4; Y is H, alkyl having 1, 2, 3 or 4 carbon atoms of which some or all may be fluorinated and one or more CH2 groups may be replaced by O, S or NR43, or is COOR44, CONR45R46, NHC(NH)NH2, phenyl or heteroaryl, and the phenyl and heteroaryl radicals may be substituted by up to 3 substituents selected from the group of CH3, CF3, OH, OCH3 or NH2; R43, R44, R45 and R46 are each independently H, CH3, CH2CH3, CF3 or CH2CF3, R39 is H; R40 is H, CH3, CH2CH3, CF3 or CH2CF3; R41 and R42 are each independently H, CH3, CH2CH3, CF3, CH2CF3) COCH3, COCH2CH3, COCF3 or COCH2CF3; in which at least one of the R7, R8 or R9 radicals has to be defined by the -L-G group, and also its pharmaceuticallyacceptable salts and trifluoroacetates. 5. A compound of the formula I as claimed in one or more of claims 1 to 4, selected from the group of N-[4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinoline-4-yl)phenyl]-2,3,4,5,6- pentahydroxyhexanamide, N-[4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinoline-4-yl)phenyl]-2,3,4,5,6- pentahydroxyhexanamide, N[4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinoline-4-yl)phenyl]-2,3,4,5,6- pentahydroxyhexanamide, N-[3-((S)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinoline-4-yl)phenyl]-2,3,4,5,6- pentahydroxyhexanamide, N-[3-((R)-6,8-dichloro-2-meethyl-1,2,3,4-tetrahydroisoquinoline-4-yl)phenyl]-2,3,4,5,6- pentahydroxyhexanamide, 1-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-3-(2-hydroxy-1- hydroxymethylethyl)urea, 1-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-3-(2-hydroxy-1- bishydroxymethylethyl)urea, 1-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-3-(2,3,4,5,6- pentahydroxyhexyl)urea, 1-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin~4-yl)phenyl]-3-(2,4,5- trihydroxy-6-hydroxymethyltetrahydropyran-3-yl)urea, {N-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-N-(1-sulfo-2- ethyl)}urea, {N-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-N-(1-ethyl-2- trimethylammonium)}urea chloride, {N-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-N-(1-carboxy-3- hydroxy-2-propyl)}urea, {N-[3-(6)8-dichloro-2-methyl-1,213,4-tetrahydroisoquinolin-4-yl)phenyl]-N'-(1-carboxy-4- aminocarboxy-2-butyl)}urea, 3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)-N-(2,3,4,5,6- pentahydroxyhexyl)benzamide, 3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)-N-(2-hydroxy-1- hydroxymethylethyl)benzamide, 2-[3-(6,8-dichloro-2-methyl-1,2I3,4-tetrahydroisoquinolin-4-yl)benzoylamino]-3- hydroxypropionic acid, 2-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)benzoylamino]succinic acid, 2-[3-(6)8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)benzoylamino]-4- succinamic acid, N-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-N-(1-carboxy-5- guanidino-2-pentyl]urea, {N-[3-(6,8-dichloro-2-methyl-1,2,3,4»tetrahydroisoquinolin-4-yl)phenyl]-N'-(1-carbo aminocarboxy-2-butyl)}urea, {N-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-N'-(1-carboxy-3- hydroxy-2-propyl)}urea, 1-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-3-(2-hydroxy-1,1- bishydroxymethylethyl)urea, 1-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-3-(2,3,4,5,6- pentahydroxyhexyl)urea, 5-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)N,N-bis(2-hydroxy-1- hydroxymethylethyl)isophthalamide, 5-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)-N,N'-bis(2-hydroxy-1,1- bishydroxymethylethyl)isophthalamide, 5-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)-N-bis(2-hydroxy-1,1- bishydroxymethyIethyl)isophthalamide, 5-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)-N,N,-bis(2,3,4,5,6- pentahydroxyhexyl)isophthalamide, 5-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)-N-(2,3,4,5,6- pentahydroxyhexyi)isophthalamide, 2-[3-(1-carboxy"2-hydroxyethylcarbamoyl)-5-(6,8-dichloro-2«methyl-1,2,3,4- tetrahydroisoquinolin-4-yl)benzoylamino]-3-hydroxypropionicacid, N-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-2-amino-5- guanidinopentanamide, N-[4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-2-amino-5- guanidinopentanamide, 2-amino-N-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-3-(1H- imidazol-4-yl)propionamide, 2-amino-N-[4-(6,8-dichloro-2-methy-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-3-(1H- imidazol-4-yl)propionamide, ethyl{3-[4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]ureido}- acetate, ethyl {3-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4«yl)phenyl]ureido}- acetate, ethyl{3-[2-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]ureido}- acetate, {3-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]ureido}acetic acid, {3-[4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]ureido}ace acid, {3-[2-(6,8-dichloro-2-methyl-l,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]ureido}acetic acid, ethyl {3-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4(R)-yl)phenyl]ureido acetate, ethyl {3-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4(R)-yl)phenyl]ureido acetate, ethyl {3-[2-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4(R)-yl)phenyl]ureido}- acetate, ethyl {3-[2-(6,8-dichloro-2-methyyl-1,2,3,4-tetrahydroisoquinolin-4(s)-yl)phenyl]ureido}- acetate, ethyl {3-[4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4(R)-yl)phenyl]ureido}- acetate, ethyl {3-[4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4(R)-yl)phenyl]ureido}- acetate, {3-[4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4(R)-yl)phenyl]ureido}acetic acid, {3-[4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4(S)-yl)phenyl]ureido}acetic acid, {3-[2-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4(R)-yl)phenyl]ureido}acetic acid, {3-[2-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4(S)-yl)phenyl]ureido}acetic acid, {3-[3-(6,8-dichloro-2-methyl-1,2,3l4-tetrahydroisoquinolin-4(R)-yl)phenyl]ureido}acetic acid, {3-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4(S)-yl)phenyl]ureido}acetic acid, 2-methoxyethyl [4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4(R)-yl)phenyl]- carbamate, 2-methoxyethyl [4-(6,8-dichloro-2-methyl-1,2)3,4-tetrahydroisoquinolin-4(S)-yl)phenyl]- carbamate, 2-methoxyethyl [3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4(R)-yl)phenyl]- carbamate, and 2-methoxyethyl [3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4(S)-yl)phenyl]- carbamate; and their pharmaceuticallyacceptable salts and trifluoroacetates. 6. A compound of the formula I as claimed in one or more of claims 1 to 5 , selected from the group of N-[4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-(2R,3S,4R,5R)- 2,3,4,5,6-pentahydroxyhexanamide, N-[3-(6>8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-(2R,3S,4R,5R)- 2,3,4,5,6-pentahydroxyhexanamide, N-[2-(6>8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-(2R,3S,4R,5R)- 2,3,4,5,6-pentahydroxyhexanamide, N-[3-((S)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]- (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanamide, N-[3-((R)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]- (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanamide, 1-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-3-(2-hydroxy-1- hydroxymethylethyl)urea, 1 -[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-3-(2-hydroxy-1,1 - bishydroxymethylethyl)urea, 1-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-3- ((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)urea, 1-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-3-((4R,5S,6R)- 2,4,5-trihydroxy-6-hydroxymethyltetrahydropyran-3-yl)urea, {N-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-N'-(1-sulfo-2- ethyl)}urea, {N-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-N'-(ethyl-2- trimethylammonium)}urea chloride, {N-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-N'-(1-carboxy-3- hydroxy-2S-propyl)}urea, {N-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-N'-(1-carboxy-4- aminocarboxy-2S-butyl)}urea, 3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)-N-((2S,3R,4R,5R)- 2,3,4,5,6-pentahydroxyhexyl)benzamide, 3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)-N-(2-hydroxy-1- hydroxymethylethyl)benzamide, 2-(SH3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)benzylamino]-3- hydroxypropionic acid, 2-(S)-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4- yl)benzoylamino]succinic acid, 2-(S)-[3-(6,8-dichloro-2-methyl-1J2,3,4-tetrahydroisoquinolin-4-yl)benzoylamino]-4- succinamic acid, N-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-N'-[1-carboxy-5- guanidirio-2S-pentyl]urea, {N-[3-(6,8 carboxy-4-aminocarboxy-2S-butyl)}urea, {N-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-(S)-yl)phenyl]-N'-(1- carboxy-4-aminocarboxy-2S-butyl)}urea, {N-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-(S)-yl)phenyl]-N'-(1- carboxy-3-hydroxy-2S-propyl)}urea, {N-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-(S)-yl)phenyi]-N'-(1- carboxy-3-hydroxy-2S-propyl)}urea, 1-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-(R)-yi)phenyl]-3(2-hydroxy- 1,1 -bishydroxymethylethyl)urea, 1-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-(S)-yl)phenyl]-3-(2-hydroxy- 1,1-bishydroxymethylethyl)urea, 1-[3-((R)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-3- ((2S,3R,4RJ5R)-2,3,4,5,6-pentahydroxyhexyl)urea, 1-[3-((S)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-3- (2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)urea, 5-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)-N,N'-bis(2-hydroxy-1- hydroxymethylethyl)isophthalamide, 5-(6,8-dichloro-2-methyl-1,2)3,4-tetrahydroisoquinolin-4-yl)-N,N,-bis(2-hydroxy-1,1- bishydroxymethylethyl)isophthalamide, 5-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)-N-(2-hydroxy-1,1- bishydroxymethylethyl)isophthalamide, 5-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)-N,N,-bis((2S,3R,4R,5R)- 2,3,4,5,6-pentahydroxyhexyl)isophthalamide, 5-(6,8-dichioro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)-N-((2S,3R,4R,5R)- 2,3,4,5,6-pentahydroxyhexyl)isophthalamide, (S)-2-[3-((S)-1-carboxy-2-hydroxyethylcarbomoyl)-5-(6,8-dichloro-2-methyl-1,2,3,4- tetrahydroisoquinolin-4-yl)benzoylamino]-3-hydroxypropionicacid, (s)-N-[3-(6,8-dichloro-2-methyl-l,23,4-tetrahydroisoquinolin-4-yl)phenyl]-2-amino-5- guanidinopentanamide, (S)-N-[4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-2-amino-5- guanidinopentanamide, (S)-2-amino-N-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-3- (1 H-imidazol-4-yl)propionamide, (S)-2-amino-N-[4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-3- (1 H-imidazol-4-yl)propionamide, ethyl {3-[4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]ureido}- acetate, ethyl {3-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]ureido}- acetate, ethyl {3-[2-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]ureido}- acetate, {3-[3-(6,8-dichloro^-methyl-l,2,3,4-tetrahydroisoquinolin-4-yl)phenyl}ureido}acetic acid, {3-[4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]ureido}acetic acid, {3-[2-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]ureido}acetic acid, ethyl {3-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4(R)-yl)phenyl]ureido}- acetate, ethyl {3-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4(R)-yl)phenyl]ureido}- acetate, ethyl {3-[2-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4(R)-yl)phenyl]ureido}- acetate, ethyl {3-[2-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4(S)-yl)phenyl]ureido}- acetate, ethyl {3-[4-(6,8-dichloro-2-1,2,3,4-tetrahydroisoquinolin-4-(R)-yl)phenyl]ureido acetate, ethyl {3-[4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4(S)-yl)phenyl]ureido}- acetate, {3-[4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4(R)-yl)phenyl]ureido}acetic acid, {3-[4-(6J8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4(S)-yl)phenyl]ureido}acetic acid, {3-[2-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinoIin-4(R)-yl)phenyl]ureido}acetic acid, {3-[2-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4(S)-yl)phenyl]ureido}acetic acid, {3-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinoIin-4(R)-yl)phenyl]ureido}acetic acid, {3-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4(S)-yl)phenyl]ureido}acetic acid, 2-methoxyethyl [4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4(R)-yl)phenyl]- carbamate, 2-methoxyethyl [4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4(S)-yl)phenyl]- carbamate, 2-methoxyethyl [3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4(R)-yl)phenyl]- carbamate, and 2-methoxyethyl [3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4(S)-yl)phenyl]- carbamate; and their pharmaceuticallyacceptable salts and trifluoroacetates. 7. A compound of the formula I and its pharmaceuticallyacceptable salts as claimed in one or more of claims 1 to 6 for use as a medicament. 8. The use of a compound of the formula I and the pharmaceuticallyacceptable salts thereof as claimed in one or more of claims 1 to 6 for preparing a medicament for the treatment or prophylaxis of disorders of respiratory drive, of respiratory disorders, sleep-related respiratory disorders, sleep apneas, of snoring, of acute and chronic renal disorders, of acute renal failure and of chronic renal failure, of disorders of intestinal function, of high blood pressure, of essential hypertension, of disorders of the central nervous system, of disorders resulting from CNS overexcitability, epilepsy and centrally induced convulsions or of anxiety states, depressions and psychoses, of ischemic states of the peripheral or central nervous system and of stroke, of acute and chronic damage to and disorders of peripheral organs or limbs caused by ischemic or by reperfusion events, of atherosclerosis, of disorders of lipid metabolism, of thromboses, of disorders of biliary function, of infestation by ectoparasites, of disorders resulting from endothelial dysfunction, of protozoal disorders, of malaria, for the preservation and storage of transplants for surgical procedures, for use in surgical operations and organ transplantations or for the treatment of states of shock or of diabetes and late damage from diabetes or of diseases in which cellular proliferation represents a primary or secondary cause, and for maintaining health and prolonging life. 9. The use of a compound of the formula I and the pharmaceuticallyacceptable salts thereof as claimed in one or more of claims 1 to 6 in combination with other medicaments or active ingredients for preparing a medicament for the treatment or prophylaxis of disorders of respiratory drive, of respiratory disorders, sleep-related respiratory disorders, sleep apneas, of snoring, of acute and chronic renal disorders, of acute renal failure and of chronic renal failure, of disorders of intestinal function, of high blood pressure, of essential hypertension, of disorders of the central nervous system, of disorders resulting from CNS overexcitability, epilepsy and centrally induced convulsions or of anxiety states, depressions and psychoses, of ischemic states of the peripheral or central nervous system and of stroke, of acute and chronic damage to and disorders of peripheral organs or limbs caused by ischemic or by reperfusion events, of atherosclerosis, of disorders of lipid metabolism, of thromboses, of disorders of biliary function, of infestation by ectoparasites, of disorders resulting from endothelial dysfunction, of protozoal disorders/of malaria, for the preservation and storage of transplants for surgical procedures, for use in surgical operations and organ transplantations or for the treatment of states of shock or of diabetes and late damage from diabetes or of diseases in which cellular proliferation represents a primary or secondary cause, and for maintaining health and prolonging life. 10. The use of a compound of the formula I and/or the pharmaceuticallyacceptable salts thereof as claimed in one or more of claims 1 to 6 alone or in combination with other medicaments or active ingredients for preparing a medicament for the treatment or prophylaxis of disorders of respiratory drive and/or of sleep-related respiratory disorders such as sleep apneas. 11. The use of a compound of the formula I and/or the pharmaceuticallyacceptable salts thereof as claimed in one or more of claims 1 to 6 alone or in combination with other medicaments or active ingredients for preparing a medicament for the treatment or prophylaxis of snoring. 12. The use of a compound of the formula I and/or the pharmaceuticallyacceptable salts thereof as claimed in one or more of claims 1 to 6 alone or in combination with other medicaments or active ingredients for preparing a medicament for the treatment or for the prophylaxis of acute or chronic renal disorders, of acute renal failure and of chronic renal failure. 13. The use of a compound of the formula I and/or the pharmaceuticallyacceptable salts thereof as claimed in claims 1 to 6 alone or in combination with other medicaments or active ingredients for preparing a medicament for the treatment or prophylaxis of disorders of intestinal function. 14. A curative composition for human, veterinary or phytoprotective use comprising an effective amount of a compound of the formula I and/or of a pharmaceuticallyacceptable salt thereof as claimed in one or more of claims 1 to 6. 15. A curative composition for human, veterinary or phytoprotective use comprising an effective amount of a compound of the formula I and/or of a pharmaceutically acceptable salt thereof as claimed in one or more of claims 1 to 6, in combination with other pharmacological active ingredients or medicaments.

Documents:

2376-chenp-2005-abstract.pdf

2376-chenp-2005-claims.pdf

2376-chenp-2005-correspondnece-others.pdf

2376-chenp-2005-description(complete).pdf

2376-chenp-2005-form 1.pdf

2376-chenp-2005-form 3.pdf

2376-chenp-2005-form 5.pdf

2376-chenp-2005-others.pdf

2376-chenp-2005-pct.pdf