Title of Invention

EMULSIFIABLE MYCO-CHEMICAL HERBICIDE AND PROCESS FOR THE PREPARATION THEREOF

Abstract

Emulsifiable myco-chemical comprising 10 5 to 10 9 spores/g or ml of Gibbago trianthemae, 10 to 50% by weight of a phenylthiopyrimidine, 15 to 50% by weight of surfactant(s) and 50 to 75% by weight of water. Also a process for the preparation of the herbicide by mixing under stirring at 26±2º C 10 5 to 10 9 spores/g or ml of Gibbago trianthemae, 10 to 50% by weight of phenylthiopyrimidine, 15 to 50% by weight of surfactant(s) and 50 to 75% by weight of water.

Full Text

FORM 2 THE PATENTS ACT, 1970 (39 of 1970) As amended by the Patents (Amendment) Act, 2005 & The Patents Rules, 2003 As amended by the Patents (Amendment) Rules, 2005 COMPLETE SPECIFICATION (See section 10 and rule 13) TITLE OF THE INVENTION Emulsifiable myco-chemical herbicide and process for the preparation thereof APPLICANTS Name : Godrej Agrovet Limited, Address : Pirojshanagar, Eastern Express Highway Vikhroli (East), Mumbai 400 079 Maharashtra, India Nationality : an Indian Company INVENTORS Name : Dr Bohra Burhanuddin, Dr Vyas Brahmanand Ambashankar, Dr Mistry Keki Bamanshaw and Godrej Nadir Burjor, Address : Godrej Agrovet Limited, Pirojshanagar, Eastern Express Highway, Vikhroli (East), Mumbai 400 079, Maharashtra India Nationality : all Indian Nationals PREAMBLE TO THE DESCRIPTION The following specification particularly describes the nature of this invention and the manner in which it is to be performed : FIELD OF INVENTION This invention relates to an emulsifiable myco-chemical herbicide and process for the preparation thereof. PRIOR ART Cotton crops like several other cultivated crop plants get infested by a variety of weeds, the most predominant and obnoxious of them being Trianthema portulacastrum. Herbicidal compositions of phenylthiopyrimidines of the Formula I wherein X is a halogen atom such as flouro, chloro, bromo or iodo and M is an alkalimetal ion such as sodium or potassium, are reported to possess excellent herbicidal activity against perennial and annual weeds and have at the same time a high level of safety to the crop plants. The surfactants and dispersing agents used in the preparation of the above compositions are alcohol sulfuric acid ester, alkyl aryl sulfonate, lignin sulfonate, polyoxy ethylene glycol ether, polyoxyethylene alkyl aryl ether or polyoxyethylene sorbitol monoalkylate (US Patent No 4932999). We have described in our patent application No 579/MUM/2004 a process for the preparation of an emulsifiable myco-chemical herbicide concentrate comprising Alternaria alternata and phenylthiopyrimidines and in our patent application No 29/MUM/2005 divided from the above application the above herbicide concentrate itself. Phytopathogenic fungus, Gibbago trianthemae is reported to cause disease in the Trianthema portulacastrum weeds eventually leading to their death (Simmons 1986, Mitchell, 1988). OBJECTS OF INVENTION An object of the invention is to provide an emulsifiable myco-chemical herbicide for crops, especially cotton crop which is very selective or specific to and very effective in controlling Trianthema portulacastrum weeds. 3 Another object of the invention is to provide an emulsifiable myco-chemical herbicide for crops, especially cotton crops which has low persistence in the environment and is environment friendly. Another object of the invention is to provide an emulsifiable myco-chemical herbicide for crops, especially cotton crops, which is economical. Another object of the invention is to provide an emulsifiable myco-chemical herbicide for crops, especially cotton crops which is storage stable. Another object of the invention is to provide a process for the preparation of an emulsifiable myco-chemical herbicide for crops, especially cotton crops which is very selective or specific to and very effective in controlling Trianthema portulacastrum weeds. Another object of the invention is to provide a process for the preparation of an emulsifiable myco-chemical herbicide for crops, especially cotton crops which has low persistence in the environment and is environment friendly. 4 Another object of the invention is to provide a process for the preparation of an emulsifiable myco-chemical herbicide for crops, especially cotton crops which is economical. Another object of the invention is to provide a process for the preparation of an emulsifiable myco-chemical herbicide for crops, especially cotton crops which is storage stable. Another object of the invention is to provide a process for the preparation of an emulsifiable myco-chemical herbicide for crops, especially cotton crops which is simple, easy and convenient to carry out. Another object of the invention is to provide a method of selectively or specifically and effectively controlling Trianthema portulacastrum weeds in crops, especially cotton crops using the emulsifiable myco- chemical herbicide. 5 DETAILED DESCRIPTION OF THE INVENTION According to the invention there is provided an emsulsifiable myco-chemical herbicide comprising 105 to 10 spores/g or ml of Gibbago trianthemae, 10 to 50 % by weight of a phenylthiopyrimidine of the Formula I wherein X is a halogen atom such as flouro, chloro, bromo or iodo and M is an alkalimetal ion such as sodium or potassium, 15 to 50 % by weight of surfactant(s) and 50 to 75 % by weight of water. The surfactants / dispersing agents used in the invention may be any known surfactant / dispersing agent including those reported in US Patent No 4932999. Ethoxylated lauryl alcohol and ethoxylated octyl phenol are preferred surfactants as they have low persistence in the environment and are environment friendly. Also they occur in nature and are easily available and cheap. 6 Preferably, the emulsifiable myco-chemical herbicide comprises 10 to 10 spores/g or ml of Gibbago trianthemae, 10 to 15 % by weight of a phenylthiopyrimidine, 15 to 50 % by weight of the surfactants ethoxylated lauryl alcohol and ethoxylated octyl phenol in the weight ratio of 10:90-9 : 10 and 50 to 75% by weight of water. Still preferably, the emulsifiable myco-chemical herbicide comprises 25 % by weight of the surfactants ethoxylated lauryl alcohol and ethoxylated octyl phenol in the weight ratio of 25 : 75 to 75 : 25. Preferably, the phenylthiopyrimidine used in the emulsifiable myco- chemical herbicide is sodium 2-chloro-6-[4,6-dimethoxy-2-pyrimidinyl)thio] benzoate. According to the invention there is also provided a process for the preparation of an emsulsifiable myco-chemical herbicide comprising mixing under stirring at 26 + 2°C 105 to 109 spores/g or ml of Gibbago trianthemae, 10 to 50 % by weight of a phenylthiopyrimidine of the Formula I 7 wherein X is a halogen atom such as flouro, chloro, bromo or iodo and M is an alkalimetal ion such as sodium or potassium, 15 to 50 % by weight of surfactant(s) and 50 to 75 % by weight of water. Preferably, the process comprises mixing 10 to 10 spores/g or ml of Gibbago trianthemae, 10 to 15 % by weight of a phenylthiopyrimidine 15 to 50 % by weight of the surfactants ethoxylated lauryl alcohol and ethoxylated octyl phenol in the weight ratio of 10:90-90: 10 and 50 to 75 % by weight of water. Still preferably, the process comprises mixing 25 % by weight of the surfactants ethoxylated lauryl alcohol and ethoxylated octyl phenol in the weight ratio 25 : 75 to 75 : 25. Preferably the process comprises mixing sodium 2-chloro-6-[4,6-dimethoxy-2-pyrimidinyl)thio] benzoate as the phenylthiopyrimidine. 8 According to the invention there is also provided a method of selectively or specifically and effectively controlling Trianthema portulacastrum weeds in crops especially cotton crops by applying or spraying the emulsifiable myco-chemical herbicide described above on the crops. The herbicide of the invention is to be diluted with water in the volume ratio 1 : 400 to 1 : 1600 prior to applying or spraying on the crops. The following experimental examples are illustrative of the invention but are not limitative of the scope thereof: Example 1 Five hundred ml spore suspension of Gibbago trianthemae ( 109 spores / ml) was mixed with 31.25g sodium 2-chloro-6-[4,6-dimethoxy-2-pyrimidinyl)thio] benzoate, 78.12g ethoxylated lauryl alcohol and ethoxylated octyl phenol ( 25% w/w) in the weight ratio 25 : 75 and 500 litres of water under stirring at room temperature (26±2°C) to obtain a spray solution for one hectare area containing 106 spores/ ml of fungus Gibbago trianthemae, 0.00625% by weight of the sodium 2-chloro-6-[4,6-dimethoxy-2-pyrimidinyl)thio]benzoate and 9 0.0156 % by weight of ethoxylated lauryl alcohol and ethoxylated octyl phenol. Example 2 Five hundred ml spore suspension of Gibbago trianthemae (10 spores / ml) was mixed with 46.875g sodium 2-chloro-6-[4,6-dimethoxy-2-pyrimidinyl)thio] benzoate, 117.18g ethoxylated lauryl alcohol and ethoxylated octyl phenol ( 25% w/w) in the weight ratio 75:25 and 500 litres of water under stirring at room temperature (26±2°C) to obtain a spray solution for one hectare containing 105 spores/ ml of fungus Gibbago trianthemae, 0.0093% by weight of the sodium 2-chloro-6-[4,6-dimethoxy-2-pyrimidinyl )thio]benzoate and 0.0156 % by weight of ethoxylated lauryl alcohol and ethoxylated octyl phenol. Using the myco-chemical herbicide solutions of Examples 1 and 2 comparative studies were carried out on 28 days old Trianthema portulacastrum weeds by spraying only once on one hectare of cotton crop divided into 6 equal zones. The results recorded after 30 days of spraying were as given in the following Table: 10 TABLE SN Treatments in 500 litres of spray solution / ha Percent Mortality of Trianthema Percent loss in bio mass over control 1 Spray of aqueous suspension of Gibbago trianthemae (106 spores/ml.) in zone 1 66.6 55.6 2 Spray of pyrithiobac sodium (31.25 g/ha) in zone 2 55.5 50.6 3 Spray of pyrithiobac sodium (62.5 g/ha) in zone 3 84.4 62.5 4 Herbicide solution of Example 1 in zone 4 96.2 70.7 5 Herbicide solution of Example 2 in zone 5 96.6 66.1 6 Control (water spray) in zone 6 0.0 0.0 Pyrithiobac sodium is a common name of cotton herbicide comprising sodium 2-chloro-6-[4-6-dimethoxy-2-pyrimidinyl}thio]benzoate in combination with the surfactants namely ethoxylated lauryl alcohol and ethoxylated octyl phenol The data in the above Table clearly show that the herbicide solutions of Examples 1 and 2 were very selective or specific to Trianthema portulacastrum and very effective in controlling them. The efficacy of the herbicide solutions of Example 1 and 2 was better than that of Pyrithiobac sodium applied at the recommended dose of 62.5 g/ha (SN 4 and 5 and SN 3). Also the efficacy of 11 Gibbago trianthemae and that of Pyrithiobac sodium at half the dosage when sprayed individually was reduced considerably (SN 1 and 2). According to the invention the herbicide thereof is very selective or specific to the weed Trianthema portulacastrum and very effective in controlling the weed. The herbicide is economical in that Gibbago trianthemae is naturally occurring and is inexpensive and in that at the application stage it requires reduced quantity of the expensive phenylthiopyrimidines and surfactants per hectare. Due to the reduced quantity of the active ingredient as well as surfactants, persistence of the herbicide in the environment is reduced thereby reducing environmental problems. The surfactants ethoxylated lauryl alchol and ethoxylated octyl phenol have low persistence in the environment as compared to the other surfactants and dispersing agents reported. Therefore, herbicide of the invention comprising ethoxylated lauryl alcohol and ethoxylated octyl phenyl has still low persistence in the environment and is further environment friendly. Ethoxylated lauryl alcohol and ethoxylated octyl phenol are also naturally occurring and easily available and cheap. Using the above surfactants in the herbicide of the invention, it can be made further economical. The process of the invention involves simple mixing of the ingredients and is therefore, simple, easy and convenient to carry out. 12 The herbicide of Examples 1 and 2 was stored for 6 months and was found to be quite stable at the end of 6 months. WE CLAIM 1. Emsulsifiable my co-chemical herbicide comprising 105 to 109 spores/g or ml of Gibbago trianthemae, 10 to 50 % by weight of a phenylthiopyrimidine of the Formula I wherein X is a halogen atom such as flouro, chloro, bromo or iodo and M is an alkalimetal ion such as sodium or potassium, 15 to 50 % by weight of surfactant(s) and 50 to 75 % by weight of water. 2. Emulsifiable myco-chemical herbicide as claimed in claim 1, which comprises 106 to 108 spores/g or ml of Gibbago trianthemae , 10 to 15 % by weight of a phenylthiopyrimidine 15 to 50 % by weight of the surfactants ethoxylated lauryl alcohol and ethoxylated octyl phenol in the weight ratio of 10 : 90 - 90 : 10 and 50 to 75 % by weight of water. 14 3. Emulsifiable myco-chemical herbicide as claimed in claim 1 or 2, which comprises 25 % by weight of the surfactants ethoxylated lauryl alcohol and ethoxylated octyl phenol in the weight ratio of 25 : 75 to 75 : 25. 4. Emulsifiable myco chemical herbicide as claimed in any one of claims 1 to 3, wherein the phenylthiopyrimidine is sodium 2-chloro-6-[4,6-dimethoxy-2-pyrimidinyl)thio] benzoate. 5. A process for the preparation of an emulsifiable myco-chemical herbicide comprising mixing under stirring at 26 ± 2°C 105 to 109 spores/g or ml of Gibbago trianthemae , 10 to 50 % by weight of a phenylthiopyrimidine of the Formula I 15 wherein X is a halogen atom such as flouro, chloro, bromo or iodo and M is an alkalimetal ion such as sodium or potassium, 15 to 50 % by weight of surfactant(s) and 50 to 75 % by weight of water. 6. A process as claimed in claim 5 which comprises mixing 106 to 108 spores/g or ml of Gibbago trianthemae , 10 to 15 % by weight of a phenylthiopyrimidine I, 15 to 50 % by weight of the surfactants ethoxylated lauryl alcohol and ethoxylated octyl phenol in the weight ratio of 10 : 90 - 90 : 10 and 50 to 75 % by weight of water. 7. A process as claimed in claim 5 or 6, which comprises mixing 25 % by weight of the surfactants ethoxylated lauryl alcohol and ethoxylated octyl phenol in the weight ratio 25:75 to 75 : 25. 8. A process as claimed in any one of claims 5 to 7 which comprises mixing sodium 2-chloro-6-[4,6-dimethoxy-2-pyrimidinyl)thio] benzoate as the phenylthiopyrimidine. 9. A method of selectively or specifically and effectively controlling Trianthema portulacastrum weeds in crops especially cotton crops by applying or spraying 16 the emulsifiable myco-chemical herbicide as claimed in any one of claims 1 to 4 on the crops. Dated this 20th day of January 2006 17 ABSTRACT Emulsifiable my co-chemical comprising 105 to 109 spores/g or ml of Gibbago trianthemae, 10 to 50 % by weight of a phenylthiopyrimidine, 15 to 50 % by weight of surfactant(s) and 50 to 75 % by weight of water. Also a process for the preparation of the herbicide by mixing under stirring at 26±2° C 105 to 109 spores/g or ml of Gibbago trianthemae, 10 to 50 % by weight of a phenylthiopyrimidine, 15 to 50 % by weight of surfactant(s) and 50 to 75 % by weight of water.

Documents:

103-MUM-2006-ABSTRACT(23-1-2006).pdf

103-mum-2006-abstract(25-4-2008).doc

103-MUM-2006-ABSTRACT(7-10-2008).pdf

103-MUM-2006-ABSTRACT(GRANTED)-(4-3-2009).pdf

103-mum-2006-abstract.doc

103-mum-2006-abstract.pdf

103-mum-2006-cancelled pages(23-1-2006).pdf

103-MUM-2006-CANCELLED PAGES(25-4-2008).pdf

103-MUM-2006-CLAILMS(7-10-2008).pdf

103-MUM-2006-CLAIMS(23-1-2006).pdf

103-MUM-2006-CLAIMS(AMENDED)-(25-4-2008).pdf

103-mum-2006-claims(granted)-(25-4-2008).doc

103-MUM-2006-CLAIMS(GRANTED)-(4-3-2009).pdf

103-mum-2006-claims.doc

103-mum-2006-claims.pdf

103-MUM-2006-CORRESPONDENCE(11-2-2009).pdf

103-MUM-2006-CORRESPONDENCE(5-2-2009).pdf

103-MUM-2006-CORRESPONDENCE(7-10-2008).pdf

103-MUM-2006-CORRESPONDENCE(IPO)-(23-3-2009).pdf

103-mum-2006-correspondence(ipo)-(4-3-2009).pdf

103-mum-2006-correspondence-received.pdf

103-mum-2006-description (complete).pdf

103-MUM-2006-DESCRIPTION(COMPLETE)-(23-1-2006).pdf

103-MUM-2006-DESCRIPTION(COMPLETE)-(7-10-2008).pdf

103-MUM-2006-DESCRIPTION(GRANTED)-(4-3-2009).pdf

103-MUM-2006-FORM 1(16-2-2008).pdf

103-mum-2006-form 1(23-1-2006).pdf

103-mum-2006-form 18(6-6-2006).pdf

103-mum-2006-form 2(7-10-2008).pdf

103-MUM-2006-FORM 2(COMPLETE)-(23-1-2006).pdf

103-mum-2006-form 2(granted)-(25-4-2008).doc

103-MUM-2006-FORM 2(GRANTED)-(4-3-2009).pdf

103-MUM-2006-FORM 2(TITLE PAGE)-(7-10-2008).pdf

103-MUM-2006-FORM 2(TITLE PAGE)-(COMPLETE)-(23-1-2006).pdf

103-MUM-2006-FORM 2(TITLE PAGE)-(GRANTED)-(4-3-2009).pdf

103-MUM-2006-FORM 26(16-2-2006).pdf

103-mum-2006-form 26(31-1-2006).pdf

103-mum-2006-form 3(23-1-2006).pdf

103-mum-2006-form-1.pdf

103-mum-2006-form-2.doc

103-mum-2006-form-2.pdf

103-mum-2006-form-3.pdf

103-MUM-2006-OTHER DOCUMENT(7-10-2008).pdf