Title of Invention

SOLID DISPERSIONS OR SOLID DISPERSION PHARMACEUTICAL PREPARATIONS OF PHENYLALANINE DERIVATIVES

Abstract

A solid dispersion or medicinal solid dispersion preparation which comprises a water-soluble polymer and either a phenylalanine compound represented by the formula (1) [wherein A represents the formula (2), etc.; B represents alkoxy, etc.; E represents hydrogen, etc.; D represents substituted phenyl, etc.; T, U, and V each represents carbonyl, etc.; Arm represents a benzene ring, etc.; R1 represents alkyl, etc.; R2, R3, and R4 are the same or different and each represents hydrogen, substituted amino, etc.; and J and J" each represents hydrogen, etc.] or a pharmaceutically acceptable salt of the compound; a process for producing the dispersion or preparation; and a solubilized medicinal preparation which comprises the compound (I) or pharmaceutically acceptable salt and a dissolution agent. Although the medicinal solid dispersion preparation or solubilized medicinal preparation contains as an active ingredient a phenylalanine compound represented by the formula (1), which is a sparingly soluble drug, it has high solubility and high oral absorbability can be obtained.

Full Text

SPECIFICATION SoHd Dispersions or Solid Dispersion Pharmaceutical Preparations of Phenylalanine Derivatives Technical Field of the Invention The present invention relates to soUd dispersions or sohd dispersion pharmaceutical preparations of phenylalanine derivatives or pharmaceutically acceptable salts thereof, which have an a 4 integrin inhibiting activity and are useful as agents for treating inflammatory bowel diseases and the like. Further, the present invention also relates to solubihzed pharmaceutical preparations of the above derivatives or pharmaceutically acceptable salts thereof. Background of the Invention Conventionally, it has been known that solubihty or absorbability of poorly-soluble drugs is improved by dispersing the poorlysoluble drugs in polymers to form soUd dispersions. For instance, there has been known that the solubility and the Hke are improved by dispersing Griseofiilvin in polyethyleneglycol polymer that is a water-soluble polymeric substance to form a sohd dispersion (Non-Patent Literature l). Incidentally, compounds of the formula (l), which are a subject of the present invention, or pharmaceutically acceptable salts thereof are the compounds which have an a 4 integrin inhibiting activity and are useful as agents for treating inflammatory bowel diseases and the hke. Though they can be produced in accordance with the description of Patent Literature 1 and the pubHcation discloses tablets, capsules, and the hke wherein the compound of the formula (l) or pharmaceutically acceptable salts thereof are dispensed, there is no disclosure on sohd dispersions or sohd dispersion pharmaceutical preparations therein. There is no disclosure on solubHized pharmaceutical preparations, either. The compounds of the formula (l) or pharmaceutically acceptable salts thereof are poorly-soluble drugs and their solubility or absorbability needs to be improved. [Patent Literature l] WO02/16329 [Non-Patent Literature l] J. Pharm. Sci., 60, 9, pp 1281-1302, (1971) Disclosure of the Invention The object of the present invention is to provide a form wherein the solubility or absorbabihty of the compound of the formula (l) or pharmaceutically acceptable salts thereof is improved, and a pharmaceutical preparation thereof. The inventors variously studied the above problem to solve it from the view of pharmaceutical preparation, and found that the solubility and absorbability of the compound of the formula (l) or pharmaceutically acceptable salts thereof is improved by treating the compounds in amorphous state with a water-soluble polymeric substanceCs) to form a solid dispersion. The present invention has been completed based on this finding. They also have found that the solubiUty and absorbability of the compound of the formula (l) or pharmaceutically acceptable salts thereof is improved by dissolving and dispersing the compounds in a solubilizer(s). The present invention has also been completed based on this finding. In this case, a surfactant(s) or a pharmaceutically acceptable oil(s) may be added to the compounds. Namely, the present invention relates to a soHd dispersion wherein a phenylalanine compound of the following formula (l) Oiereinafter referred to as a compound (I)) or pharmaceutically acceptable salts thereof is dispersed in amorphous state in a water-soluble polymeric substance(s): ring thereof, an aryl group, a heteroaryl group, a lower alkyl group substituted with a cycloalkyl group (s) which may contain a hetero atom(s) in the ring thereof, a lower alkyl group substituted with an aryl group(s), a lower alkyl group substituted with a heteroaryl group(s), a lower alkoxy group, a lower alkylthio group, a lower alkoxy group and lower alkylthio group substituted with a cycloalkyl group(s) which may contain a hetero atom(s) in the ring thereof, a lower alkoxy group and lower alkylthio group substituted with an aryl group(s), a lower alkoxy group and lower alkylthio group substituted with a heteroaryl group(s), a cycloalkyloxy group which may contain a hetero atom(s) in the ring thereof, an aryloxy group, a heteroaryloxy group, a hydroxy-lower alkyl group, a hydroxy-lower alkenyl group, a hydroxy-lower alkoxy group, a halogeno-lower alkyl group, a halogeno-lower alkoxy group, a halogeno-lower alkylthio group, a halogeno-lower alkenyl group, nitro group, cyano group, a substituted or unsubstituted amino group, carboxyl group, a lower alkyloxycarbonyl group, a substituted or unsubstituted carbamoyl group, a lower alkanoyl group, an aroyl group, a lower alkylsulfonyl group, a substituted or unsubstituted sulfamoyl group or an ammonium group, R^and R^ may be bonded together to form a ring which may contain one or two oxygen, nitrogen or sulfur atoms, B represents a hydroxyl group, a lower alkoxy group or hydroxylamino group, E represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower alkyl group substituted with a cycloalkyl group(s) which may contain a hetero atom(s) in the ring thereof, a lower alkyl group substituted with an aryl group(s) or a lower alkyl group substituted with a heteroaryl group(s), D represents a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a cycloalkyl group which may contain a hetero atom(s) in the ring thereof, an aryl group, a heteroaryl group, a lower alkyl group substituted with a cycloalkyl group(s) which may contain a hetero atom(s) in the ring thereof, a lower alkyl group substituted with an aryl group (s), a lower alkyl group substituted with a heteroaryl group(s), a lower alkoxy group, a lower alkoxy group substituted with a cycloalkyl group(s) which may contain a hetero atom(s) in the ring thereof, a lower alkoxy group substituted with an aryl group(s), a lower alkoxy group substituted with a heteroaryl group(s), a cycloalkyloxy group which may contain a hetero atom(s) in the ring thereof, an aryloxy group, a heteroaryloxy group, a hydroxy-lower alkyl group, a hydroxy-lower alkenyl group, a hydroxy-lower alkoxy group, a halogeno-lower alkyl group, a halogeno-lower alkoxy group, a halogeno-lower alkenyl group, a nitro group, a cyano group, a substituted or unsubstituted amino group, a carboxyl group, a lower alkyloxycarbonyl group, a substituted or unsubstituted carbamoyl group, a lower alkanoyl group, an aroyl group, a lower alkylthio group, a lower alkylsulfonyl group or a substituted or unsubstituted sulfamoyl group, E and D may be bonded together to form a ring which may contain one or two oxygen, nitrogen or sulfur atoms, T represents an interatomic bond, C(=0), C(=S), S(=0), S(=0)2, N(H)-C(=0), or N(H)-C(=S), and J and J' may be the same or different from each other and each represent a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkyloxy group or nitro group. The present invention also relates to a sohd dispersion pharmaceutical preparation which is prepared by processing the above sohd dispersion with one or more steps selected from mixing, granulation, kneading, tableting, capsule fLUing, and coating. Additionally, the present invention relates to a soHd dispersion pharmaceutical preparation which is prepared by coating a core component containing the above sohd dispersion with a coating agent(s). The present invention further relates to a method for producing the sohd preparation which adopts either one of steps of: (i) dissolving or dispersing the above compound (I) or pharmaceutically acceptable salts thereof in an organic solvent(s) together with a water-soluble polymeric substance(s), and then removing the organic solvent(s); Gi) dissolving or dispersing the above compound (I) or pharmaceutically acceptable salts thereof in a water-soluble polymeric substance(s) under heating, and then cooling the mixture; Gil) dissolving or dispersing the above compound (I) or pharmaceutically acceptable salts thereof in a water-soluble polymeric substance(s) under heating and under pressure, and then coohng the mixture; and (iv) mixing the above compound (I) or pharmaceutically acceptable salts thereof together with a water-soluble polymeric substance(s), and then grinding the mixture. The present invention further relates to a solubilized pharmaceutical preparation containing a solubilizer(s) and the above compound (I) or pharmaceutically acceptable salts thereof. Brief Description of the Drawings Fig. 1 shows an explanatory chart of the powder X-ray diffraction of Example 1. Fig. 2 shows an explanatory chart which indicates shifts of the concentration of the compound A in blood plasma when sohd dispersions of Examples 12 and 13, a solubOized pharmaceutical preparation of Example 25, a suspension obtained in Comparative Example 1, and ordinary tablets obtained in Comparative Example 2 were administered to beagle dogs for oral administration. Fig. 3 shows an explanatory chart which indicates shifts of the concentration of the compound A in blood plasma when solid dispersion pharmaceutical preparations of Examples 14 to 18, a suspension obtained in Comparative Example 1, and ordinary tablets obtained in Comparative Example 2 were administered to beagle dogs for oral administration. Fig. 4 shows an explanatory chart which indicates shifts of the concentration of the compound A in blood plasma when solid dispersion pharmaceutical preparations of Examples 19 to 24 were administered to beagle dogs for oral administration. Fig. 5 shows an explanatory chart which indicates a shift of the concentration of the compound A in blood plasma when a sohd dispersion pharmaceutical preparation of Example 26 was administered to beagle dogs for oral administration. Best Mode for Carrjdng out the Invention In the definition of each group in the formulae (l), (2), (3-1), and (3-2) in the present specification, the term 'lower" in, for example, a lower alkyl group indicates that the group has 1 to 6 carbon atoms and preferably 1 to 4 carbon atoms. Alkyl groups per se and also alkyl groups in alkenyl groups, alkynyl groups, alkoxy groups, alkylthio groups, alkanoyl groups and alkylamino groups, alkenyl groups and alkynyl groups may be either linear or branched. Examples of these alkyl groups are a methyl group, ethyl group, propyl group, isopropyl group, butyl group, secondary butyl group, tertiary butyl group, pentyl group and hexyl group. It is preferable that the alkyl groups have 1 to 6 carbon atoms and more preferable that the groups have 1 to 4 carbon atoms. The alkenyl groups are, for example, a vinyl group, propenyl group, butenyl group and pentenyl group. It is preferable that the alkenyl groups have 2 to 6 carbon atoms and more preferable that the groups have 2 to 4 carbon atoms. The alkynyl groups include an ethynyl group, propynyl group and butynyl group. It is preferable that the alkynyl groups have 2 to 8 carbon atoms and more preferable that the groups have 2 to 4 carbon atoms. The cycloalkyl groups indicate substituted or unsubstituted cycloalkyl groups such as a cyclopropyl group, cyclobutyl group, cyclopentyl group, cyclohexyl group, norbornyl group, adamantyl group and cyclohexenyl group. It is preferable that the cycloalkyl groups have 3 to 8 carbon atoms and more preferable that the groups have 3 to 5 carbon atoms. The alkoxy groups include a methoxyl group, ethoxyl group, propyloxy group, isopropyloxy group, etc. It is preferable that the alkoxy groups have 1 to 6 carbon atoms and more preferable that the groups have 1 to 4 carbon atoms. The hetero atoms include nitrogen, oxygen, sulfur, etc. The halogen atoms are fluorine, chlorine, bromine and iodine. The halogenoalkyl groups include a chloromethyl group, trichloromethyl group, trifluoromethyl group, trifluoroethyl group, pentafluorom ethyl group, etc. The halogenoalkoxy groups include a trichloromethoxy group, trifluoromethoxy group, etc. The hydroxyalkyl groups include a hydroxymethyl group, hydroxyethyl group, etc. The cycloalkyl groups which may contain a hetero atom(s) in the ring thereof may be either substituted or unsubstituted. Examples of them include a cyclopentyl group, cyclohexyl group, piperidyl group, piperazinyl group, morphohnyl group, pyrroHdinyl group, tetrahydrofuranyl group and uracil group, which are preferably 4-to-8-membered cycUc group, and more preferably 5-to-7-membered cycUc group. The aryl groups are both substituted and unsubstituted aryl groups such as a phenyl group, 1-naphthyl group and 2-naphthyl group. They are preferably a phenyl group and substituted phenyl group, and the substituents are particularly preferably halogen atoms, alkoxy groups, alkyl groups, hydroxyl group, halogenoalkyl groups and halogenoalkoxy groups. The heteroaryl groups are both substituted and unsubstituted heteroaryl groups such as a pyridyl group, pyrazyl group, pyrimidyl group, pyrazolyl group, pyrrolyl group, triazyl group, furyl group, thienyl group, isoxazolyl group, isothiazolyl group, indolyl gi'oup, quinolyl group, isoquinolyl group, benzimidazolyl group and imidazolyl group. Preferable heteroaryl groups are a pyridyl group, pyrazyl group, pyrimidyl gi'oup, furyl group, thienyl group, imidazolyl group and substituted pyridyl, furyl and thienyl groups. Particularly preferable substituents are halogen atoms, alkoxy groups, alkyl groups, hydroxyl group, halogenoalkyl groups and halogenoalkoxy groups. The lower alkyl groups substituted with an aryl group(s) include, for example, substituted or unsubstituted benzyl groups and substituted or unsubstituted phenethyl groups. Particularly preferable substituents are halogen atoms, alkoxy groups, alkyl groups, hydroxyl group, halogenoalkyl groups and halogenoalkoxy groups. The lower alkyl groups substituted with a heteroaryl group(s) include, for example, a pyridylmethyl group, and particularly preferable substituents thereof are halogen atoms, alkoxy groups, alkyl groups, hydroxyl group, halogenoalkyl groups and halogenoalkoxy groups. The alkanoyl groups include, for example, a formyl groups, acetyl groups, propanoyl group, butanoyl group and pivaloyl group. The aroyl groups include, for example, substituted or unsubstituted benzoyl groups and a pyridylcarbonyl group, and the substituents thereof are particularly preferably halogen atoms, alkoxy groups, alkyl groups, hydroxyl group, halogenoalkyl groups and halogenoalkoxy groups. The halogenoalkanoyl groups include, for example, a trichloroacetyl group and triQuoroacetyl group. The alkylsulfonyl groups include, for example, a methanesulfonyl group, ethanesulfonyl group, etc. The arylsulfonyl groups include, for example, a benzenesiilfonyl group and p-toluenesulfonyl group. The heteroarylsulfonyl groups include, for example, a pyridylsulfonyl group. The halogenoalkylsulfonyl groups include, for example, a trifluoromethanesulfonyl group. The alkyloxycarbonyl groups include, for example, a methoxycarbonyl group, ethoxycarbonyl group and tert-butoxycarbonyl group. The aryl-substituted alkoxycarbonyl groups include, for example, a benzyloxycarbonyl group and 9-fluorenylmethoxycarbonyl group. The substituted carbamoyl groups include, for example, a methylcarbamoyl group, phenylcarbamoyl group and substituted phenylcarbamoyl group, and the substituents thereof are particularly preferably halogen atoms, alkoxy groups, alkyl groups, hydroxyl group, halogenoalkyl groups and halogenoalkoxy groups. The substituted thiocarbamoyl groups include, for example, a methylthiocarbamoyl group, phenylthiocarbamoyl group and substituted phenylthiocarbamoyl groups, and the substituents thereof are particularly preferably halogen atoms, alkoxy groups, alkyl groups, hydroxyl group, halogenoalkyl groups and halogenoalkoxy groups. The substituted amino groups herein indicate mono-substituted or di-substituted amino groups and the substituents thereof include lower alkyl groups, lower alkyl groups substituted with an aryl group, lower alkyl groups substituted with a heteroaryl group, lower alkanoyl groups, aroyl groups, halogeno-lower alkanoyl groups, lower alkylsulfonyl groups, arylsulfonyl groups, heteroarylsulfonyl groups, halogenoalkylsuMbnyl groups, lower alkyloxycarbonyl groups, aryl-substituted lower alkyloxycarbonyl groups, substituted or unsubstituted carbamoyl groups and substituted or unsubstituted thiocarbamoyl groups. The ammonium groups include such as trialkylammonium groups. Because the phenylalanine compounds of the formula (l) of the present invention include asymmetric carbons, it is thinkable that the compounds are optical isomers and the compounds indicated in the present invention include the said optical isomers. However, L-form is preferable. Regarding the compounds in which a diastereomer exists, the diastereomer and the diastereomer compound are included in the said phenylalanine compounds. Because the phenylalanine compounds of the formula (l) of the present invention include a mobile hydrogen atom, it is thinkable that the compounds of the present invention are a variety of tautomeric forms and the compounds indicated in the present invention include the said tautomeric forms. Further, the carboxyl groups of the compound of the present invention may be substituted with appropriate substituents which are converted into a carboxyl group in vivo. An example of such substituents is a lower alkoxycarbonyl group. When the compounds of the formula (l) of the present invention can form salts thereof, the salts are pharmaceutically acceptable ones. When the compound has an acidic group such as carboxyl group in the formula, the salts can be salts thereof with alkah metals, e. g. sodium, potassium and ammonium, salts thereof with alkaline earth metals, e. g. calcium and magnesium, salts thereof with aluminum and zinc, salts thereof with organic amines, e. g. triethylamine, ethanolamine, morpholine, piperidine and dicyclohexylamine, and salts thereof with basic amino acids, e. g. arginine and lysine. When the compound has a basic group in the formula, the salts can be those with inorganic acids, e. g. hydrochloric acid, sulfuric acid and phosphoric acid; those with organic carboxylic acids, e. g. acetic acid, citric acid, benzoic acid, maleic acid, fumaric acid, tartaric acid and succinic acid; and those with organosulfonic acids, e. g. methanesulfonic acid and p-toluenesulfonic acid. The salts can be formed by mixing a compound of the formula (l) with a necessitated acid or base in a proper ratio in a solvent or dispersing agent or by the cation exchange or anion exchange reaction with another salt. The compounds of the formula (l) of the present invention include also solvates thereof such as hydrates and alcohol adducts thereof. The compound (I) or pharmaceutically acceptable salts thereof can be produced by the method described in WO02/16329 (Patent Literature l). The description of WO02/16329 is included in that of the present specification. The concrete examples of the compound (I) include Examples 1 to 213 described in WO02/16329 (Patent Literature l). In the compound (I) or pharmaceutically acceptable salts thereof, the phenylalanine compound of the formula (l) is preferably a compound wherein Rl represents a methyl group or an ethyl group; and R2, R3, and R4 represent a hydrogen atom, a halogen atom, a hydroxyl group, a substituted low alkyl group, a substituted lower alkenyl group, a substituted lower alkynyl group, a heteroaryl group, a hydroxy-lower alkyl group, an amino group substituted with a lower alkyl group, or a carbamoyl group substituted with a lower alkyl group, wherein the substituents in the substituted low alkyl group, the substituted lower alkenyl group and the substituted lower alkynyl group include an amino group, an amino group substituted with a lower alkyl group, a carboxyl group, a lower alkoxycarbonyl group, a cyano group, a lower alkylthio group, and a lower alkylsulfonyl group. The compound (I) or pharmaceutically acceptable salts thereof are preferably Examples 1, 108, 162, 169, 122, 66, 91, 99, 89, 75, 147, 148, 202, 201, 196, 193, 198 or 197 described in WO02/16329 (Patent Literature l). They are shown as foUows. cellulose acetate phthalate; synthetic polymers, e.g. polyethyleneglycol, polyvinyl alcohol, polyvinylpyrroHdone, polyvinylacetal diethylaminoacetate, aminoalkyl methacrylate copolymer E, aminoalkyl methacryl copolymer RS, methacryhc acid copolymer L, methacrylic acid copolymer LD, methacrylic acid copolymer S, and carboxylvinyl polymer; and natural polymers and sugars, e.g. gum arabic, sodium alginate, propylene glycol alginate, agar, gelatin, tragacanth, and xanthan gum as preferable examples. The water-soluble polymeric substances include methylcellulose, hydroxypropylmethylceUulose, hydroxj^ropylcellvdose, polyethyleneglycol, polyvinyl alcohol, polsrvinylpyrrolidone, and the like, and methylcellulose and hydroxypropylmethylceUulose are particularly preferably used. These polymeric substances can be used by its own or by mixture. In the solid dispersions or solid dispersion pharmaceutical preparations of the present invention, the ratio between the compound (I) and the water-soluble polymeric substance(s) is preferably 0.1 to 100 parts by weight of the latter to 1 part by weight of the former, more preferably 0.25 to 20 parts by weight thereof and further more preferably selected from the range of 0.5 to 10 parts by weight thereof The solid dispersions of the present invention can be prepared, for example, by a solvent method, a melt method, a melt-kneading method under heating and pressure, or a mixing grinding method. The solvent method is the method that the compound (1) or pharmaceutically acceptable salts thereof are dissolved or dispersed in an organic solvent(s) together with a water-soluble polymeric substance(s), and then the organic solvent(s) is removed in accordance with the ordinary methods. The methods for dissolving or dispersing the compounds in an organic solvent(s) are^ (i) dissolving or dispersing the compound (1) or pharmaceutically acceptable salts thereof by themselves in an organic solvent(s), and further dispersing this solution in a water-soluble polymeric substance(s); and Gi) dissolving or dispersing the compound (I) or pharmaceutically acceptable salts thereof together with a water-soluble polymeric substance(s) in the organic solvent(s). The organic solvents used in the solvent method are the solvents that dissolve or disperse the compound (I) or pharmaceutically acceptable salts thereof, and not particularly hmited. The organic solvents include ahphatic halogenated hydrocarbons, e.g. dichloromethane, dichloroethane and chloroform; alcohols, e.g. methanol, ethanol and propanol; ketones, e.g. acetone and methylethylketone; ethers, e.g. diethylether and dibutylether; ahphatic hydrocarbons, e.g. nhexane, cyclohexane and n-heptane; aromatic hydrocarbons, e.g. benzene, toluene and xylene; organic acids, e.g. acetic acid and propionic acid; esters, e.g. ethyl acetate; amides, e.g. dimethylformamide and dimethylacetamide; and mixed solvents thereof. The halogenated hydrocarbons, alcohols and the mixed solvents thereof are preferable among them. Dichloromethane, methanol, ethanol and the mixed solvents thereof are further more preferable among them. The organic solvents used in the solvent method also include mixed solvents of the above organic solvents and water. The methods for dispersing and adsorbing the compound (I) or pharmaceutically acceptable salts thereof to a water-soluble polymeric substance(s) include the method comprising the steps of- dissolving the compound (I) or pharmaceutically acceptable salts thereof in an organic solvent(s), further dissolving or dispersing a water-soluble polymeric substance(s) in the organic solvent(s), and then removing the organic solvent(s) under reduced pressure or normal pressure in accordance with ordinary methods; or that comprising the steps of: dissolving the compound (I) or pharmaceutically acceptable salts thereof in an organic solvent(s), further dissolving or dispersing a water-soluble polymeric substance(s) in the organic solvent(s), granulating or mixing the mixed solution together with auxiliaries such as diluents and disintegrant using agitation granulators, fluid bed granulators, spraydiyers, Bohle container mixer, V-mixers and the Uke, and then removing the organic solvent(s) under reduced pressure or normal pressure in accordance with ordinary methods. Removal of an organic solvent(s) can be conducted, for example, by drying under reduce pressure or drjdng under heating. The conditions such as the treatment pressure, temperature and time vary depending on used compounds, water-soluble polymeric substances, organic solvents and the like. The treatment pressure is within the range of ImmHg to normal pressure; the treatment temperature is within the range of room temperature to 250*0; and the treatment time is within the range of a few minutes to several days. The melt method is the method that the compound (I) or pharmaceutically acceptable salts thereof are dissolved or dispersed under heating in a water-soluble polymeric substance(s) and then cooled down. The methods for dissolving or dispersing the compounds include stirring by heating the compounds up to or higher than the melting point or the softening point of the compound (I) or pharmaceutically acceptable salts thereof or those of the water-soluble polymeric substance(s). In this case, plasticizers, e.g. polyethyleneglycol, sucrose fatty acid ester, glycerine fatty acid ester, propylene glycol, triethyl citrate, caster oil and triacetin; and surfactants, e.g. sodium lauryl sulfate, polysolvate 80, sucrose fatty acid ester, polyoxyl 40 stearate, polyoxyethylene 60 hydrogenated caster oil, sorbitan monostearate, and sorbitan monopalmitate can be added thereto as additives. The solid dispersion pharmaceutical preparations by the melt method can be produced using agitation granulators with heating, for example. More concretely, a mixture of a water-soluble polymeric substance(s) and the compound (I) or pharmaceutically acceptable salts thereof is prepared in advance. The above plasticizers or surfactants may be added to the mixture, if necessary. The conditions such as the treatment temperature and time vary depending on used compounds, water-soluble polymeric substances, additives and the like. The treatment temperature is within the range of room temperature to 300°C; and the treatment time is within the range of a few minutes to ten and several hours. The cooling temperature is within the range of -100°C to room temperature. The melt-kneading method under heating and pressure is the method that the compound (I) or pharmaceutically acceptable salts thereof and a water-soluble polymeric substance(s) are mixed under heating and pressure. The conditions such as the treatment screw rotation speed, temperature and time vary depending on used compounds, water-soluble polymeric substances, additives and the Uke. The treatment screw rotation speed is within the range of 10 to SOOrpm; the treatment temperature is within the range of room temperature to SOO^C; and the treatment time is within the range of a few minutes to ten and several hours. The soHd dispersions by the melt-kneading method under heating and pressure are produced using double-shaft kneading extruders with a heating device and kneading machines, for example. More concretely, for instance, they are produced by the following method. The compound (I) or pharmaceutically acceptable salts thereof and a water-soluble polymeric substance(s), and the above additives, if necessary, are mixed in advance. The mixture is provided at the speed of powder supply of 10 to 200g/min. The treatment is conducted in the conditions of the treatment screw rotation speed of 50 to SOOrpm; and the treatment temperature of 25 to 300°C. This plastic-like solid dispersion is ground by a mill to obtain a soHd dispersion. The mixing grinding method is the method that the compound (I) or pharmaceutically acceptable salts thereof are mixed with a water-soluble polymeric substance(s) and then they are nulled so that the compound (I) or pharmaceutically acceptable salts thereof become in amorphous state. Mixing and milling are conducted using mixers and mills in accordance with ordinary methods. Here, milling of water-soluble polymers and the compound (I) is preferably conducted by cutter mills, ball mills, hammer mills, mortars and the like. The soHd dispersions of the present invention can be used as powders, fine granules or granules without change, or they can be further prepared in accordance with ordinary methods as solid dispersion pharmaceutical preparations such as tablets and capsules via processes for producing preparations (e.g. mixing, granulating, kneading, tableting, capsule filling, and coating). The mixing indicates, for example, the process where the soUd dispersions of the present invention are mixed with other compounds by mixers. The granulating indicates, for example, the process where the soHd dispersions of the present invention are granulated by agitation granulators. The kneading indicates, for instance, the process where the soHd dispersions of the present invention are kneaded by kneading machines. The tableting indicates, for instance, the process where the soMd dispersions of the present invention are prepared as tablets by tableting machines. The capsule filling indicates, for example, the process where the soHd dispersions of the present invention are filled in capsules by capsule filling machines. The coating indicates, for example, the process where the soHd dispersions of the present invention are coated with coating agents by coating machines. When preparing drugs, if necessary, additives can be added thereto, such as diluents Hke sugars, e.g. lactose, sucrose, glucose, reduced maltose, mannitol, sorbitol, xylitol and trehalose, starches and derivatives thereof, e.g. partially Oi starch, dextrin, puUvdan, corn starch and potato starch, celluloses, e.g. crystalline cellulose, microcrystalline cellulose, crystalline cellulose / carmeUose sodium and hydroxypropyl cellulose, magnesium aluminometasilicate, silicon dioxide, fight anhydrous sfiicic acid, and amino acids; coloring agents! flavoring agents, e.g. sucrose, aspartame, mannitol, dextran, saccharin, menthol, citric acid, tartaric acid, malic acid, ascorbic acid, sweet hydrangea leaves, fennel, ethanol, fructose, xylitol, glycyrrhizinic acid, purified sucrose, Lglutamine and cyclodextrin," disintegrants, e.g. hydroxypropyl cellulose, low-substituted hydroxypropyl cellulose, croscarmeUose sodium, a starch, methylcellulose, sodium alginate, sodium carboxymethyl starch, carmeUose calcium, carmellose sodium, crystalline cellulose and crystalline cellulose / carmellose sodium; lubricants, e.g. magnesium stearate, talc, Hght anhydrous silicic acid, calcium stearate, magnesium oxide, sodium lauryl sulfate and magnesium aluminometasilicate; and surfactants, e.g. sodium lauryl sulfate, polysolvate 80, sucrose fatty acid ester, polyoxyl 40 stearate, polyoxyethylene 60 hydrogenated caster oil, sorbitan monostearate and sorbitan monopalmitate. In the solid dispersion pharmaceutical preparations of the present invention, the core component containing the solid dispersion may be particles of the solid dispersion itself or a substance wherein the soUd dispersion is granulated with other components for preparation. When the core component is the solid dispersion itself, the solid dispersion is preferably milled to be granulated. When the core component is the substance wherein the solid dispersion is granulated with other components for preparation, it is preferably granulated by mixing, fluid bed, extruding, and spraydxying with agitation granulators, fluid bed granulators, extruding granulators, Bohle container mixer, V-mixers, spraydryers and the hke. The solid dispersion pharmaceutical preparations of the present invention may contain foaming agents, and such preparations containing foaming agents are preferable in the soUd dispersion pharmaceutical preparations of the present invention. The forming agents are not particularly limited in the present invention and usually preferably consist of a reagent acting as a carbon dioxide source and a reagent inducing release of carbon dioxide. The reagents acting as a carbon dioxide source include monobasic or dibasic salts of pharmaceutically acceptable carbonic acids such as alkali metal carbonates, e.g. sodium carbonate, potassium carbonate, sodium hydrogen carbonate and potassium hydrogen carbonate, or alkali metal bicarbonates; alkah earth metal carbonates, e.g. calcium carbonate, magnesium carbonate and barium carbonate; and sodium glycine carbonate. These monobasic or dibasic salts of carbonic acids may be used by itself or by mixing two or more of them. Sodium hydrogen carbonate is preferable among them. The reagents inducing release of carbon dioxide include pharmaceutically acceptable organic acids and salts and acid anhydrides thereof such as succinic acid, tartaric acid, citric acid, malic acid, ascorbic acid, maleic acid, fiimaric acid, adipic acid, anhydrides of citric acid, anhydrides of succinic acid, monosodium citrate, disodium citrate, sodium dihydrogenphosphate, oxahc acid and potassium dihydrogen phosphate. They may be used by itself or by mixing two or more of them. Tartaric acid, citric acid and ascorbic acid are preferable among them and tartaric acid is particularly preferable among them. In the sohd dispersions or the soUd dispersion pharmaceutical preparations of the present invention, the ratio between the compound (A) and the foaming agents is preferably 0.001 to 200 parts by weight of the latter to 1 part by weight of the former, more preferably 0.01 to 1 parts by weight thereof and further more preferably selected from the range of 0.06 to 50 parts by weight thereof. Further, the ratio between monobasic or dibasic salts of carbonic acids as reagents acting as a carbon dioxide source and organic acids and salts thereof and acid anhydrides is preferably 0.01 to 100 parts by weight of the latter to 1 part by weight of the former, more preferably 0.1 to 50 parts by weight thereof and further more preferably selected from the range of 0.25 to 25 parts by weight thereof The methods for mixing monobasic or dibasic salts of carbonic acids with organic acids and salts and acid anhydrides thereof are preferably mixing with Bohle container mixer and V-mixers or shaking by hands. In the sohd dispersion pharmaceutical preparations of the present invention, the pharmaceutical preparations may be prepared by adding foaming agents to the solid dispersions and then tableting. The methods for adding the foaming agents include adding thereof together with a raw material and components for preparation during granulation, and mixing thereof in the obtained grantdes after the granulation. When the obtained granules and foaming agents are granulated together, they can be granulated by agitation ganulation, fluid bed granulation, extruding granulation, and spray-drying with agitation granulators, fluid bed granvilators, extruding grantdators, and spray-dryers and the hke. In case of adding foaming agents to the obtained granules after the granulation, it is preferable that they are mixed by Bohle container mixer, V-mixers, agitation granulators, and fluid bed granulators. After that, the following coating agents may be apphed thereto. In the sohd dispersion pharmaceutical preparations of the present invention, any coating agents are usable if they are regularly used in the pharmaceutical field. They include acryhc acid derivatives, e.g. methacrylic acid copolymer L, methacryhc acid copolymer S, methacryhc acid copolymer LD and aminoaUcyl methacrylate copolymer E; cellulose derivatives, e.g. hydroxypropylmethylceUulose phthalate, hydroxy- propylmethylceUulose acetate succinate, carboxymethylethylceUulose, cellulose acetate phthalate, hydroxy ethylcellulose, hydroxypropylcellulose, hydroxypropylmethylceUulose, methylceUulose, methyUiydroxy- ethylcellulose, opadry, carmellose calcium and carmellose sodium; vinyl derivatives, e.g. polyvinylpyrrolidone, polyvinyl alcohol and polyvinylacetal diethylaminoacetate; starches, e.g. dextrin and pullulan; and natural polymers and sugars, e.g. shellac, gelatin, agar and gum Arabic. One or more of these coating bases can be used. They are preferably aminoalkyl methacrylate copolymer E, hydroxypropylmethylcellulose, methylceUulose, methylhydroxyethyl-cellulose, opadry, carmellose calcium and carmellose sodium, polyvinylpyrroUdone, polyvinyl alcohol, dextrin, pullulan, gelatin, agar and gum Arabic. In coating, plasticizers, e.g. polyethyleneglycol, sucrose fatty acid ester, glycerine fatty acid ester, propylene glycol, triethyl citrate, caster oil and triacetin; or light shielding agents, e.g. titanium oxide and iron sesquioxide can be combined with coating agents in order to assist film forming property of film base materials and give new features. Here, the coating quantity is within the amount by which the dissolution rate of the solid dispersion does not change drastically. The coverage of the soHd part of the preparation is, for example, 0.1 to 20weight%, preferably 0.5 to 10weight% and more preferably 1 to 7weight%. The solubilized pharmaceutical preparations of the present invention are those that contain a solubilizer(s) and the compound (I) or pharmaceutically acceptable salts thereof, and they may further contain a surfactant(s) or pharmaceutically acceptable oils therein. The solubilizers in the solubilized pharmaceutical preparations include propylene carbonate, propylene glycol, and polyethyleneglycols such as polyethyleneglycol 600, triethyl citrate, glycerin monofatty acids, e.g. glycerin monocaprate and glycerin monooleate, tricapryline, polysolvate 80, lauromacrogol, polyoxyethylene hydrogenated caster oils, glycerin, olive oil, sorbitan oleate ester, sorbitan laurate ester, diethylene glycol monoethyl ether, medium-chain triglyceride, oleyl alcohol, oleic acid, capric acid, hydrochloric acid, and lactic acid. They are preferably propylene carbonate, propylene glycol, polyethyleneglycols, triethyl citrate, glycerin monocaprate, and glycerin monooleate among them. As the surfactants in the solubihzed pharmaceutical preparations. nonionic surfactants, ionic surfactants, and hydrophobic surfactants can be used. The nonionic surfactants include polyoxyethylene surfactants, e.g. polyoxyethylene alkylether, polyoxyethylene alkylphenol, polyoxyethylene hydrogenated caster oil, polyoxyethylene monofatty acid, polyoxyethylene monopolyoxyethylene glycol fatty acid ester, polyoxyethylene glyceol fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene-polyoxypropylene glycol polyoxyethylene glyderide, polyoxyethylene sterol, polyoxyethylene vegetable oil and polyoxyethylene hydrogenated vegetable oil; alkyl glucoside, alkyl maltoside, allcyl thioglucoside, lauryl macrogolglyceride, poly glyceol fatty acid ester, saccharose ester, saccharose ether and glyceride. Further, they also include the reaction mixture of polyalcohols and at least one kind selected from the group consisting of fatty acid, glyceride, vegetable oil, hydrogenated vegetable oil and sterol. The ionic surfactants include bile salts, amino acids, alkylammonium salts, fatty acid condensation products of oligopeptides or polypeptides, phospholipids and lysophosphoHpids. The hydrophobic surfactants include polyoxyethylene alkylether, bile acid, acetylated glyceol fatty acid ester, lactic acid ester, and propyleneglycol diglyceride. The polyoxyethylene surfactants are preferable among them, and polyoxyethylene hydrogenated caster oils, e.g. polyoxyethylene 50, 60, 100 hydrogenated caster oils (HCO50, 60, lOO); polyoxyethylene monofatty acids, e.g. polyoxyl 40 stearate; and polyoxyethylene-polyoxypropylene glycols, e.g. pluronic and PEP 101. The pharmaceutically acceptable oils in the solubilized pharmaceutical preparations include myristic acid, oleic add, soybean oil, sorbitan monofatty acids such as sorbitan monooleate, glycerin esters of fatty acids such as oleic acid glycerin ester, capryHc acid glycerin ester and laurylic acid glycerin ester, and polyoxy ethylene hydrogenated caster oils such as polyoxy ethylene 10 hydrogenated caster oil and polyoxy ethylene 30 hydrogenated caster oil. They are preferably glycerin esters of fatty acids having 6 to 18 carbon atoms such as oleic acid glycerin ester, caprylic acid glycerin ester and laurylic acid glycerin ester, and polyoxy ethylene hydrogenated caster oUs such as polyoxy ethylene 10 hydrogenated caster oil and polyoxy ethylene 30 hydrogenated caster oil. Though the solubilizers have a solubihzing effect by themselves, they are preferably used in combination with pharmaceutically acceptable surfactants or oils. The solubilized pharmaceutical preparations are preferably those prepared in combination with (i) polyoxy ethylene surfactants and (u) either one of pharmaceutically acceptable oils selected from glycerin esters of fatty acids having 6 to 18 carbon atoms, polyoxy ethylene hydrogenetated caster oils, sorbitan fatty acid esters, and propylene glycol fatty acid esters. The solubilized pharmaceutical preparations are further more preferably those prepared in combination with G) polyoxyethylene 60 hydrogenated caster oil and (ii) either one of pharmaceutically acceptable oils selected from oleic acid glycerin esters, caprylic acid glycerin esters and laurylic acid glycerin esters, polyoxyethylene 10 hydrogenated caster oil and polyoxyethylene 30 hydrogenated caster oil. The ratios of each components of the compound (l) or pharmaceutically acceptable salts thereof, surfactants, solubilizers, and pharmaceutically acceptable oils are, when regarding the compound (I) or pharmaceutically acceptable salts thereof as 1, that the solubihzers are within the weight ratio of 1 to 100! the surfactants are within the weight ratio of 0.1 to 20; and the pharmaceutically acceptable oils are within the weight ratio of 0.01 to 20- The methods for producing the solubilized pharmaceutical preparations include the method that the compound (I) or pharmaceutically acceptable salts thereof are dispersed and dissolved in a solubilizer(s) using agitator, homogenizers, high-pressure homogenizers or ultrasonic homogenizers to produce the preparations. In case of containing surfactants or pharmaceutically acceptable oils, there is the method that the surfactants or the pharmaceutically acceptable oils are added and mixed to the compound (I) or pharmaceutically acceptable salts thereof and a solubilizer(s) to produce the preparations. The solubilized pharmaceutical preparations are preferably administered as solutions, emulsions, preparations filled in capsules, or preparations adsorbing drugs on the diluents. The emulsions are formed by mixing the above solutions with suitable aqueous diluents or diluting the solutions with the diluents. The preparations filled in capsules are formed, for example, by filling the above solutions in gelatin. The present invention includes solid dispersions, solid dispersion pharmaceutical preparations or solubilized pharmaceutical preparations, which can rapidly disintegrate and dissolve the preparations containing the compound (I) or pharmaceutically acceptable salts thereof in the stomach. The solid dispersions or the solid dispersion pharmaceutical preparations of the present invention drastically improve pharmacokinetic parameters such as biological availability and show the excellent oral absorbability as compared with suspensions or ordinary tablets. In addition to it, the solubilized pharmaceutical preparations of the present invention improve pharmacokinetic parameters such as biological availability and show the excellent oral absorbabihty as compared with suspensions or ordinary tablets. Examples will further illustrate the soUd dispersions, the sohd dispersion pharmaceutical preparations and the solubilized pharmaceutical preparations of the present invention. They only explain the present invention and do not particularly limit the invention. Meanwhile, in the following description, the compound (A) is Example 196 in WO02/16329 (Patent Literature l). (Example l) A solid dispersion (polyvinylpyrrolidone^ 0.1-fold amount) About 230g of dichloromethane and about 57g of methanol were added to 15g of the compound (A) and 1.5g of polj^nylpyrroUdone (KoHdon K30, BASF) and mixed weU by shaking and dissolved. The solvent of the solution was removed by a spraydryer in the conditions of inlet temperature of 80°C, hot air flow rate of 42 to 48mmH2 0 and spray speed of 8.3g/min. to form a solid dispersion. (Example 2) A soHd dispersion (poljrvinylpyrrohdone: 0.5-fold amount) About 227g of dichloromethane and about 56g of methanol were added to 15g of the compound (A) and 7.5g of pol5^nylpyrrolidone (Kohdon K30, BASF) and mixed weU by shaking and dissolved. The solvent of the solution was removed by a spray-dryer in the conditions of inlet temperature of 80°C, hot air flow rate of 40 to 48mmH2 0 and spray speed of 7.9g/min. to form a solid dispersion, (Example 3) A soHd dispersion (polyvinylpyrroHdone^ 1-fold amount) About 226g of dichloromethane and about 58g of methanol were added to lOg of the compound (A) and lOg of polyvinylpyrroUdone (Kohdon K30, BASF) and mixed weU by shaking and dissolved. The solvent of the solution was removed by a spray-dryer in the conditions of inlet temperature of 80°C, hot air flow rate of 38 to 44mmH2 0 and spray speed of 7.7g/min. to form a solid dispersion, (Example 4) Asohd dispersion (polyvinylpyrroUdone: 5-fold amount) About 227g of dichloromethane and about 57g of methanol were added to 3g of the compound (A) and 15g of polyvinylpyrrolidone (Kohdon K30, BASF) and mixed well by shaking and dissolved. The solvent of the solution was removed by a spraydryer in the conditions of inlet temperature of 80°C, hot air flow rate of 38 to 46mmH2 0 and spray speed of 8.2g/min. to form a solid dispersion. (Example 5) A solid dispersion (methylceUulose: 1-fold amount) About 220g of dichloromethane and about 55g of methanol were added to 3g of the compound (A) and 3g of methylcellulose (Metolose SM4, Shin-Etsu Chemical Co., Ltd.) and mixed well by shaking and dissolved. The solvent of the solution was removed by a spray-dryer in the conditions of inlet temperature of 80°C, hot air flow rate of 36 to 40mmH2 0 and spray speed of lOg/min. to form a soHd dispersion. (Example 6) Asohd dispersion (methylcellulose: 0.1-fold amount) About 220g of dichloromethane and about 55g of methanol were added to 30g of the compound (A) and 3g of methylcellulose (Metolose SM4, Shin-Etsu Chemical Co., Ltd.) and mixed well by shaking and dissolved. The solvent of the solution was removed by a spray-dryer in the conditions of inlet temperature of 80°C, hot air flow rate of 36 to 40mmH2 0 and spray speed of lOg/min. to form a sohd dispersion. (Example 7) A solid dispersion (methylcellulose: 0.5-fold amount) About 222g of dichloromethane and about 58g of methanol were added to 15g of the compound (A) and 7.5g of methylcellulose (Metolose SM4, Shin-Etsu Chemical Co., Ltd.) and mixed weU by shaking and dissolved. The solvent of the solution was removed by a spray-dryer in the conditions of: inlet temperature of 80°C, hot air flow rate of 40mmH2 0 and spray speed of 6g/min. to form a sohd dispersion. (Example 8) A sohd dispersion (hydroxypropylmethylcellulose: 5-fold amount) About 218g of dichloromethane and about 56g of methanol were added to 3g of the compound (A) and 15g of hydroxypropylmethylcellulose (MetoloseTC-5E, Shin-Etsu Chemical Co., Ltd.) and mixed weU by shaking and dissolved. The solvent of the solution was removed by a spray dryer in the conditions of: inlet temperature of SO^C, hot air flow rate of 36 to I 40mmH2 0 and spray speed of 9g/min, to form a soHd dispersion. (Example 9) A solid dispersion (hydroxypropylmethylcellulose phthalate-' 5-fold amount) About 229g of dichloromethane and about 57g of methanol were added to 3g of the compound (A) and 15g of hydroxypropylmethylcellulose phthalate (HPMCP HP55, Shin-Etsu Chemical Co., Ltd.) and mixed weU by shaking and dissolved. The solvent of the solution was removed by a spray-dryer in the conditions of inlet temperature of 80°C, hot air flow rate of 34 to 38mmH2 0 and spray speed of 8.1g/min. to form a solid dispersion. (Example 10) AsoHd dispersion (polyethyleneglycol: 5-fold amount) About 228g of dichloromethane and about 57g of methanol were added to 3g of the compound (A) and 15g of polyethyleneglycol 6000 (PEG6000, NOF CORPORATION) and mixed weU by shaking and dissolved. The solvent of the solution was removed by a spray-dryer in the conditions of inlet temperature of 80°C, hot air flow rate of 36 to 44mmH2 0 and spray speed of 8.2g/min. to form a solid dispersion. (Example ll) A solid dispersion (poljrvinylpyrrolidone: 5-fold amount) lOOg of the compound (A) and 500g of polsrvinylpyrrolidone (KoHdon K30) were put in a plastic bag and shaken 200 times by hands to mix them. Then, the mixed powder was volumetrically provided at the speed of about 19g/min. to a kneader set to barrel temperature of 80*0 and screw rotation speed of 192rpm to obtain a solid substance. The soHd substance was ground by a grinding machine to form a soUd dispersion. ^Example 12) A soHd dispersion (methylceUulose) 80g of dichloromethane and 120g of methanol were added to lOg of methylceUulose (SM-4, Shin-Etsu Chemical Co., Ltd.) and mixed well and lissolved. 0.3g of the compound (A) was added to 26.8g of the solution, nixed well by shaking and dissolved. 0,3g of croscarmeUose sodium !Ac-Di-Sol, Asahi Kasei Corporation) was added to the solution and mixed ay shaking. The solvent thereof was removed by a rotary evaporator, and :he residue was further ground by a mortar to form a solid dispersion. (Example 13) A solid dispersion (hydroxjT)ropylmethylcellulose) 80g of dichloromethane and 120g of methanol were added to lOg of hydroxypropylmethylcellulose (TC-5R, Shin-Etsu Chemical Co., Ltd.) and mixed well by shaking and dissolved. 0.3g of the compound (A) was added to 36.7g of the solution, mixed weU by shaking and dissolved. 0.3g of croscarmellose sodium was added to the solution and mixed by shaking. The solvent thereof was removed by a rotary evaporator, and the residue was further ground by a mortar to form a soHd dispersion. (Example 14) A solid dispersion pharmaceutical preparation (methylcellulose; granulation by mixing) 205g of methanol were put into 55g of methylcellulose (SM4, Shin-Etsu Chemical Co., Ltd.) to moisten a whole methylcellulose. 820g of dichloromethane was added thereto, stirred and dissolved. Then, 22g of the compound (A) was further added thereto, stirred and dissolved. Thus prepared solution was used as a spray solution mentioned below. 150g of partially a starch (PCS PC-10, Asahi Kasei Corporation), 40g of croscarmellose sodium (Ac-Di-Sol, Asahi Kasei Corporation), 70g of low-substituted hydroxypropyl cellulose (LH-11, Shin-Etsu Chemical Co., Ltd.), lOOg of crystalline cellulose (Ceolas KG-802, Asahi Kasei Corporation) and 88g of lactose (200M, DMV) were put into the mixing tank of an agitation granulator (LFS-2, Fukae Powtec Corporation), stirred by circulating hot water of about 80°C, mixed and then dried. After that, the reaction mixture was granulated by an agitation granulator with spraying lOOOg of the above prepared spray solution under nitrogen gas stream. After the completion of spraying, the mixture was stirred and dried under reduced pressure to obtain crude granvdes. If necessary, the mixture was additionally dried by a fluid bed dryer. The obtained crude granules were sized by mill such as a speed mill. 0.5% magnesium stearate was added to the sized granules and tableted to obtain uncoated tablets. The obtained uncoated tablets were film coated with hydroxypropylmethylcellulose to obtain a solid dispersion pharmaceutical preparation. (Example 15) A solid dispersion pharmaceutical preparation (methylceUulose; fluid bed granulation) A spray solution was prepared by the same method as that of Example 14. 188g of PCS PC-10, 50g of Ac-Di-Sol, 63g of LH-11, 125g of Ceolus KG-802 and llOg of granulated lactose (DCL-11, DMV) were put into a fluid bed granulator (FLO-1, Freund Corporation), mixed and dried. Then, 1237g of the spray solution was sprayed to conduct the fluid bed granulation. After the completion of sprajdng, the mixture was dried by the fluid bed granulator to obtain granules. 0.5% magnesium stearate was added to the obtained granules and tableted to obtain uncoated tablets. The obtained uncoated tablets were film coated with hydroxypropyl- methylceUulose to obtain a soHd dispersion pharmaceutical preparation. (Example 16) A solid dispersion pharmaceutical preparation (methylceUulose; granulation by spraydrying) 3.6kg of dichloromethane, 0.9kg of methanol and 0.5kg of methylceUulose (SM4, Shin-Etsu Chemical Co., Ltd.) were stirred and dissolved. 116g of Ac-Di-Sol was added thereto and dispersed, and then 2.4kg of dichloromethane and 0,6kg of methanol were additionaUy added thereto. 200g of the compound (A) was added thereto, dissolved and dispersed. Thus obtained solution was spray dried by a spray dryer (TCSD, NIPPON SHARYO, LTD.) to obtain spraydried powder. 0.76kg of the powder was dissolved in 5.6kg of dichloromethane and 1.4kg of methanol, and spraydried by the spray dryer to obtain spraydried powder. 82g of the obtained spraydried powder, 50g of LH-11, 316g of granulated lactose (DCL-11, DMV) and 50g of crystalline ceUvilose (Avicel PH-301, Asahi Kasei Corporation) were mixed. 2.5g of magnesium stearate was further added thereto, and thus mixed powder was tableted and film coated with hydroxypropylmethylceUulose to obtain a solid dispersion pharmaceutical preparation. (Example 17) A solid dispersion pharmaceutical preparation (methylcellulose; granulation by mixing) 658g of methanol was put into 175g of methylcellulose (SM4, Shin-Etsu Chemical Co., Ltd.) to moisten a whole methylcellulose. 2635g of dichloromethane was added thereto, stirred and dissolved. Then, 35g of the compound (A) was further added thereto, stirred and dissolved. Thus prepared solution was used as a spray solution mentioned below. 83g of PCS PC-10, 26g of Ac-Di-Sol, 39g of LH-11, 77g of Ceolus KG-802 and 103g of lactose 200M were put into the mixing tank of an agitation granulator (LFS-2, Fukae Powtec Corporation), stirred by circulating hot water of about 80 °C, mixed and then dried. After that, the reaction mixture was granulated by an agitation granulator with spraying llOOg of the above prepared spray solution under nitrogen gas stream. After the completion of spraying, the mixture was stirred and dried under reduced pressure to obtain crude granules. If necessary, the mixture was additionally dried by a fluid bed dryer. The obtained crude granules were sized by miU such as a speed mill. 0.5% magnesium stearate was added to the sized granules and tableted to obtain uncoated tablets. The obtained uncoated tablets were film coated with hydroxypropylmethylcellvdose to obtain a soHd dispersion pharmaceutical preparation. (Example 18) A solid dispersion pharmaceutical preparation (hydroxypropylmethylceUulose; granulation by mixing) 302g of methanol was put into 116g of hydroxypropylmethylceUulose (TC-5E, Shin-Etsu Chemical Co., Ltd.) to moisten a whole hydroxypropylmethylceUulose. 705g of dichloromethane was added thereto, stirred and dissolved. Then, 33g of the compound (A) was further added thereto, stirred and dissolved. Thus prepared solution was used as a spray solution mentioned below. 112g of PCS PC-10, 30g of AcDi-Sol, 38g of LH-11, 75g of Ceolus KG-802 and 51g of lactose 200M were put into an agitation granulator , stirred by circulating hot water of about 80°C, mixed and then dried. After that, the reaction mixture was granulated by an agitation granulator with sprajdng 525g of the above prepared spray solution under nitrogen gas stream. After the completion of sprajdng, the mixture was stirred and dried under reduced pressure to obtain crude granules. If necessary, the mixture was additionally dried by a fluid bed dryer. The obtained crude granules were sized by mill such as a speed mill. 0.5% magnesium stearate was added to the sized granules and tableted to obtain uncoated tablets. The obtained uncoated tablets were film coated with hydroxypropylmethylceUulose to obtain a soUd dispersion pharmaceutical preparation. (Example 19) A soMd dispersion pharmaceutical preparation (methylcelluloseJ fluid bed granulation) About 1139g of methanol was put into 312.5g of methylceUulose (SM4, Shin-Etsu Chemical Co., Ltd.) to moisten a whole methylceUulose. About 4552.Ig of dichloromethane was added thereto, stirred and dissolved. Then, 250,Og of the compound (A) was further added thereto, stirred and dissolved. Thus prepared solution was used as a spray solution mentioned below. 56.0g of partially a starch (PCS PC-10, Asahi Kasei Corporation), 44.8g of croscarmellose sodium (Ac-Di-Sol, Asahi Kasei Corporation), 84.0g of crystalline cellulose (Avicel PH102, Asahi Kasei Corporation) and 22.4g of mannitol (Mannit P, TOWA CHEMICAL INDUSTRY CO., LTD.) were put into the container of a fluid bed granulator (FLO-1, Freund Corporation), mixed and dried at intake temperature of 90°C. Then, 3500g of the spray solution was sprayed in the conditions of the spray air pressure of 0.15Mpa; and spray speed of 30g/min. to conduct the fluid bed granulation. After the completion of spraying, the mixture was dried by the fluid bed granulator to obtain granules. 0.5% magnesium stearate was added to the obtained granules and tableted to obtain uncoated tablets. The obtained uncoated tablets were film coated with hydroxypropylmethylceUulose to obtain a sohd dispersion pharmaceutical preparation. (Example 20) A solid dispersion pharmaceutical preparation (methylcellulose; fluid bed granulation) About 825.0g of methanol was put into 225. Ig of methylcelltdose (SM4, Shin-Etsu Chemical Co., Ltd.) to moisten a whole methylcellulose. About 3300.Og of dichloromethane was added thereto, stirred and dissolved. Then, 150. Ig of the compound (A) was further added thereto, stirred and dissolved. Thus prepared solution was used as a spray solution mentioned below. 56.0g of PCS PC-10, 44.8g of Ac-Di-Sol, 84.0g of Avicel PH102 and 22.4g of Mannit P were put into a fluid bed granulator (FLO-1, Freund Corporation), mixed and dried. Then, 4200g of the spray solution was sprayed to conduct the fluid bed granulation. After the completion of spraying, the mixture was dried by the fluid bed granulator to obtain granules. 0.5% magnesium stearate was added to the obtained granules and tableted to obtain uncoated tablets. The obtained uncoated tablets were film coated with hydroxypropylmethylceUulose to obtain a soUd dispersion pharmaceutical preparation. (Example 2l) A solid dispersion pharmaceutical preparation (methylcellulose; fluid bed granulation) About 728.2g of methanol was put into 198.0g of methylcellulose (SM4, Shin-Etsu Chemical Co., Ltd.) to moisten a whole methylceUulose. About 2906.7g of dLchloromethane was added thereto, stirred and dissolved. Then, 132.Og of the compound (A) was further added thereto, stirred and dissolved. Thus prepared solution was used as a spray solution mentioned below. 70.0g of PCS PC-10, 44.8g of Ac-Di-Sol, 84.0g of Avicel PH102 and 47.3g of granulated lactose (DCL-11, DMV) were put into a fluid bed granulator (FLO-1, Freund Corporation), mixed and dried. Then, 3733.0g of the spray solution was sprayed to conduct the fluid bed granulation. After the completion of spraying, the mixture was dried by the fluid bed granulator to obtain granules. 0.5% magnesium stearate was added to the obtained granules and tableted to obtain uncoated tablets. The obtained uncoated tablets were jSlm coated with hydroxypropylmethylceUulose to obtain a sohd dispersion pharmaceutical preparation. (Example 22) A soHd dispersion pharmaceutical preparation (methylceUulose; fluid bed granulation) About 550.Og of methanol was put into 150.0g of methylceUulose (SM4, Shin-Etsu Chemical Co., Ltd.) to moisten a whole methylceUulose. About 2200.0g of dichloromethane was added thereto, stirred and dissolved. Then, lOO.Og of the compound (A) was further added thereto, stirred and dissolved. Thus prepared solution was used as a spray solution mentioned below. 140.0g of PCS PC-10, 44.8g of Ac-Di-Sol, 84.0g of Avicel PH102 and 55. Ig of DCL-11 were put into a fluid bed granulator (FLO-1, Freund Corporation), mixed and dried. Then, the spray solution was sprayed to conduct the fluid bed granulation. After the completion of spraying, the mixture was dried by the fluid bed granulator to obtain granules. 0.5% magnesium stearate was added to the obtained granules and tableted to obtain uncoated tablets. The obtained uncoated tablets were film coated with hydroxj^ropylmethylceUulose to obtain a solid dispersion pharmaceutical preparation. (Example 23) A solid dispersion pharmaceutical preparation (methylceUulose; fluid bed granulation) About 412.5g of methanol was put into 112.5g of methylceUulose (SM4, Shin-Etsu Chemical Co., Ltd.) to moisten a whole methylceUulose. About 1650.0g of dichloromethane was added thereto, stirred and dissolved. Then, 75.0g of the compound (A) was further added thereto, stirred and dissolved. Thus prepared solution was used as a spray solution mentioned below. 140.0g of PCS PC-10, 44.8g of Ac-Di-Sol, 84.0g of Avicel PH102, 57.4 g of DCL-11 and 56.0g of low-substituted hydroxjT)ropyl ceUulose (LHll, Shin-Etsu Chemical Co., Ltd.) were put into a fluid bed granulator (FLO-1, Freund Corporation), mixed and dried. Then, 2100g of the spray solution was sprayed to conduct the fluid bed granulation. After the completion of spraying, the mixture was dried by the fluid bed granulator to obtain granules. 0.5% magnesium stearate was added to the obtained granules and tableted to obtain uncoated tablets. The obtained uncoated tablets were film coated with hydroxypropylmethylceUulose to obtain a solid dispersion pharmaceutical preparation. (Example 24) A solid dispersion pharmaceutical preparation (methylcellulose; fluid bed granulation) About 555.0g of methanol was put into ISO.Og of methylcellulose (SM4, Shin-Etsu Chemical Co., Ltd.) to moisten a whole methylcellulose. About 2220.0g of dichloromethane was added thereto, stirred and dissolved. Then, 75.0g of the compound (A) was further added thereto, stirred and dissolved. Thus prepared solution was used as a spray solution mentioned below. 140.0g of PCS PC-10, 44.8g of AcDi-Sol, 84.0g of Avicel PH102, 57.4 g of DCL-11 and 56.0g of low-substituted hydroxypropyl cellulose (LHll, Shin-Etsu Chemical Co., Ltd.) were put into a fluid bed granulator (FLO-1, Freund Corporation), mixed and dried. Then, 2100g of the spray solution was sprayed to conduct the fluid bed granulation. After the completion of spraying, the mixture was dried by the fluid bed granulator to obtain granules. 0.5% magnesium stearate was added to the obtained granules and tableted to obtain vmcoated tablets. The obtained uncoated tablets were film coated with hydroxypropylmethylceUulose to obtain a soHd dispersion pharmaceutical preparation. (Example 25) A solubUized pharmaceutical preparation 2mL of 12N hydrochloric acid was taken and diluted with propylene carbonate (Showa Denko K.K.) to 20mL thereof. 6mL of the solution was further taken and diluted with propylene carbonate to lOmL thereof. 0.3003g of the compound (A) was taken and dissolved in 1.514g of propylene carbonate containing 0.72mol/L of hydrochloric acid. 6.00g of polyethyleneglycol 400 was added thereto and mixed weU to prepare a solubUized pharmaceutical preparation. (Example 26) A solid dispersion pharmaceutical preparation (foaming preparation) 792.0g of methanol was put into 216.0g of methylceUulose (SM4, Shin-Etsu Chemical Co., Ltd.) to moisten a whole methylceUulose. 3169.8g of dichloromethane was added thereto, stirred and dissolved. Then, 144.0g of the compound (A) was further added thereto, stirred and dissolved. Thus prepared solution was used as a spray solution mentioned below. 56.0g of partially a starch (PCS PC-10, Asahi Kasei Corporation), 44.8g of croscarmellose sodium (Ac-Di-Sol, Asahi Kasei Corporation), 84.0g of crystalline cellulose (Avicel PH102, Asahi Kasei Corporation) and 22.4g of mannitol (Mannit P, TOWA CHEMICAL INDUSTRY CO., LTD.) were put into the container of a fluid bed granulator (FLO-1, Freund Corporation), mixed and dried at intake temperature of 90°C. Then, 4230g of the spray solution was sprayed in the conditions of the spray air pressure of ClSMpai and spray speed of 30g/min. to conduct the fluid bed granulation. After the completion of spraying, the mixture was dried by the fluid bed granulator to obtain granules. Sodium hydrogen carbonate and L-tartaric acid were mixed in the weight ratio of 1^1 by shaking by hands. Then, 15g of the mixture was added to 150g of the obtained granules and mixed by a V-mixer (Mix well blender V-10, TOKUJU CORPORATION) in 30rpm for 7 minutes. Further, 0.5% magnesium stearate was added to the obtained mixture and tableted to obtain a soUd dispersion pharmaceutical preparation, which is a foaming preparation. As comparative examples, a carmellose sodium (CMCNa) suspension and ordinary tablets are explained as foUows. (Comparative Example l) CMCNa suspension 2.0g of carmellose sodium (CMCNa) powder was precisely weighed and diluted by adding water to prepare 400mL of 0.5% CMCNa solution. Besides the above, 0.2g of the compound (A) was precisely weighed and blended well with the CMCNa solution in an agate mortar to prepare lOOmL of CMCNa suspension. (Comparative Example 2) Ordinary tablets 0.3g of the compound (A), 2.7g of granulated lactose (DCL-11, DMV), 1.35g of crystalline cellulose (Avicel PH-301, Asahi Kasei Corporation), 0.15g of croscarmelose sodium (Ac-Di-Sol, Asahi Kasei Corporation) and 0.02g of magnesium stearate were weighed and mixed by a vortex mixer. Thus obtained powder was prepared as tablets to obtain ordinary tablets. Next, intravenous injection solutions are explained, which were used for calculating biological availability. (Referential Example l) An intravenous administration solution O.lg of the compound (A) was precisely weighed and added to about 30mL of polyethyleneglycol 400 (NOF Corporation), and the ultrasonic treatment was conducted thereto. Thus, the mixture was dissolved, and diluted by adding polyethyleneglycol 400 to prepare 50mL of an intravenous administration solution. (Referential Example 2) An intravenous administration solution 0.4g of the compound (A) was precisely weighed and added to about 80mL of polyethyleneglycol 400 (NOF Corporation), and the ultrasonic treatment was conducted thereto. Thus, the mixture was dissolved, and diluted by adding polyethyleneglycol 400 to prepare lOOmL of an intravenous administration solution. The effects of the solid dispersions, solid dispersion pharmaceutical preparations and solubilized pharmaceutical preparations of the present invention are explained in test examples. (Test Example l) The powders obtained in Examples 1 to 11 were evaluated on the absence or presence of crystallinity with a powder X-ray diffractometer. The followings are conditions ia measurement of powder X-ray diffraction patterns. Target: Cu full-automatic monochromator Voltage: 45kV Current: 45mV SUt: divergence 1/2 scattering 1/2 receiving 0.15mm Scan Speed: 2° / min. 2 e range: 5 to 40° Examples 1 to 11 had the same results of analysis. As one example, the results of analysis of powder X-ray diffraction in the solid dispersion of Example 1 is shown in Figure 1. Figure 1 clarifies that the compound (A) in the solid dispersion or pharmaceutically acceptable salts thereof do not form a crystalline structure. (Test Example 2) A soHd dispersion (methylceUulose) The tip of a flange of a syringe for lOmL was covered with Parafilm, and 5mL of purified water was poured therein. 0.07g of the soHd dispersion (methylceUulose) of Example 12 was precisely weighed and poured in the flange. A plunger was inserted to a gasket part in the flange and adequately shaken. Then, the soHd dispersion was forcefully administered in the stomach of a beagle dog under fasting with an oral sonde in the amount of lOmg/body (that is, lOmg of the compound (A) per one individual, hereinafter same as above). After the administration, inside of the sonde was rinsed with 30mL of purified water into the stomach. The samples of the blood plasma were taken before the administration and 0.25, 0.5, 1, 2, 4, 6, 8, and 24 hours after starting the administration. (Test Example 3) A soHd dispersion OiydroxypropylmethylceUulose) The tip of a flange of a syringe for lOmL was covered with Parafilm, and 5mL of purified water was poured therein. 0.1285g of the soHd dispersion (hydroxypropylmethylcellulose) of Example 13 was precisely weighed and poured in the flange. A plunger was inserted to a gasket part in the flange and adequately shaken. Then, the soHd dispersion was forcefully administered in the stomach of a beagle dog under fasting with an oral sonde in the amount of lOmg/body. After the administration, inside of the sonde was rinsed with 30mL of purified water into the stomach. The samples of the blood plasma were taken before the administration and 0.25, 0.5, 1, 2, 4, 6, 8, and 24 hours after starting the administration. (Test Example 4) A soUd dispersion pharmaceutical preparation Each one tablet of the soHd dispersion pharmaceutical preparations of Examples 14 to 18 was directly put in an oral cavity of a beagle dog under fasting in the amount of lOmg/body and made the dog swallow it, and 20mL of purified water was given to it. The samples of the blood plasma were taken before the administration and 0.25, 0,5, 1, 2, 4, 6, 8, and 24 hours after starting the administration. (Test Example 5) A solubilized pharmaceutical preparation 0.26g of the solubilized pharmaceutical preparation of Example 25 was precisely weighed and filled in a No. 2 hard gelatin capsule. Then, the capsule was directly put in an oral cavity of a beagle dog under fasting and made the dog swallow it (lOmg/body), and 20mL of purified water was given to it. The samples of the blood plasma were taken before the administration and 0.25, 0.5, 1, 2, 4, 6, 8, and 24 hours after starting the administration. (Test Example 6) A soHd dispersion pharmaceutical preparation Each one tablet of the soHd dispersion pharmaceutical preparations of Examples 19 to 24 was directly put in an oral cavity of a beagle dog under fasting in the amount of 40mg/body and made the dog swallow it, and 30mL of purified water was given to it. The samples of the blood plasma were taken before the administration and 0.25, 0.5, 1, 2, 4, 6, 8, and 24 hours after starting the administration. (Test Example 7) A soHd dispersion pharmaceutical preparation (containing foaming agents) One tablet of the solid dispersion phai-maceutical preparation of Example 26 was directly put in an oral cavity of a beagle dog under fasting in the amount of 40mg/body and made the dog swallow it, and 50mL of purified water was given to it. The samples of the blood plasma were taken before the administration and 0.25, 0.5, 1, 2, 4, 6, 8, and 24 hours after starting the administration. (Comparative Test Example l) CMCNa suspension 5mL of carmellose sodium (CMCNa) suspension of Comparative Example 1 was forcefully administered in the stomach of a beagle dog with an oral sonde in the amount of lOmg/body. After the administration, inside of the sonde was rinsed with 30mL of purified water into the stomach. The samples of the blood plasma were taken before the administration and 0.25, 0.5, 1, 2, 4, 6, 8, and 24 hours after starting the administration. (Comparative Test Example 2) Ordinary tablets One tablet of the ordinary tablet of Comparative Example 2 was directly put in an oral cavity of a beagle dog under fasting in the amount of lOmg/body and made the dog swallow it, and 20mL of purified water was given to it. The samples of the blood plasma were taken before the administration and 0.25, 0.5, 1, 2, 4, 6, 8, and 24 hours after starting the administration. (Referential Test Example l) An intravenous administration solution The intravenous administration solution of Referential Example 1 was administered in veins of a beagle dog under fasting in the amount of lOmg/body. The samples of the blood plasma were taken before the administration, 2, 10, 30, 60 minutes after and 2, 4, 6, 8, 24 hours after starting the administration. (Referential Test Example 2) An intravenous administration solution The intravenous administration solution of Referential Example 2 was administered in veins of a beagle dog under fasting in the amount of 40mg/body. The samples of the blood plasma were taken before the Example 1 and the ordinary tablets of Comparative Example 2. Additionally, the solubilized pharmaceutical preparations of the present invention show the excellent oral absorbability as compared with the CMCNa suspension of Comparative Example 1 and the ordinary tablets of Comparative Example 2. The present invention provides solid dispersions or soHd dispersion pharmaceutical preparations and solubilized pharmaceutical preparations, which show high solubihty and oral absorbability of the compound (I) that is a poorly-soluble drug or pharmaceuticaUy acceptable salts thereof. The soHd dispersions or soHd dispersion pharmaceutical preparations and solubiHzed pharmaceutical preparations of present invention have an or 4 integrin inhibiting activity, and are useful as therapeutic agents or preventive agents for inflammatory diseases in which a 4 integrin-depending adhesion process participates in the pathology,, rheumatoid arthritis, inflammatory bowel diseases, systemic erythematodes, multiple sclerosis, Sjogren's syndrome, asthma, psoriasis, allergy, diabetes, cardiovascular diseases, arterial sclerosis, restenosis, tumor proliferation, tumor metastasis and transplantation rejection. W represents C(-R7) or a nitrogen atom, Ri, R2, R3, R4 R5, R^and R'^ may be the same or different from one another and each represent a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group, a substituted lower alkyl group, a lower alkenyl group, a substituted lower alkenyl group, a lower alkynyl group, a substituted lower alkynyl group, a cycloalkyl group which may contain a hetero atom(s) in the ring thereof, an aryl group, a heteroaryl group, a lower alkyl group substituted with a cycloalkyl group(s) which may contain a hetero atom(s) in the ring thereof, a lower alkyl group substituted with an aryl group(s), a lower alkyl group substituted with a heteroaryl group(s), a lower alkoxy group, a lower alkylthio group, a lower alkoxy group and lower alkylthio group substituted with a cycloalkyl group(s) which may contain a hetero atom(s) in the ring thereof, a lower alkoxy group and lower alkylthio group substituted with an aryl group(s), a lower alkoxy group and lower alkylthio group substituted with a heteroaryl group(s), a cycloalkyloxy group which may contain a hetero atom(s) in the ring thereof, an aryloxy group, a heteroaryloxy group, a hydroxylower alkyl group, a hydroxylower alkenyl group, a hydroxylower alkoxy group, a halogeno-lower alkyl group, a halogeno-lower alkoxy group, a halogeno-lower alkylthio group, a halogeno-lower alkenyl group, nitro group, cyano group, a substituted or unsubstituted amino group, carboxyl group, a lower alkyloxycarbonyl group, a substituted or unsubstituted carbamoyl group, a lower alkanoyl group, an aroyl group, a lower alkylsulfonyl group, a substituted or unsubstituted sulfamoyl group or an ammonium group, R^and R^ may be bonded together to form a ring which may contain one or two oxygen, nitrogen or sulfur atoms, B represents a hydroxyl group, a lower alkoxy group or hydroxylamino group, E represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower alkyl group substituted with a cycloalkyl group(s) which may contain a hetero atom(s) in the ring thereof, a lower alkyl group substituted with an aryl group(s) or a lower alkyl group substituted with a heteroaryl group(s), D represents a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a cycloalkyl group which may contain a hetero atom(s) in the ring thereof, an aryl group, a heteroaryl group, a lower alkyl group substituted with a cycloalkyl group(s) which may contain a hetero atom(s) in the ring thereof, a lower alkyl group substituted with an aryl group (s), a lower alkyl group substituted with a heteroaryl group(s), a lower alkoxy group, a lower alkoxy group substituted with a cycloalkyl group(s) which may contain a hetero atom(s) in the ring thereof, a lower alkoxy group substituted with an aryl group (s), a lower alkoxy group substituted with a heteroaryl group (s), a cycloalkyloxy group which may contain a hetero atomCs) in the ring thereof, an aryloxy group, a heteroaryloxy group, a hydroxylower alkyl group, a hydroxylower alkenyl group, a hydroxy-lower alkoxy group, a halogeno-lower alkyl group, a halogeno-lower alkoxy group, a halogeno-lower alkenyl group, nitro group, cyano group, a substituted or unsubstituted amino group, carboxyl group, a lower alkyloxycarbonyl group, a substituted or unsubstituted carbamoyl group, a lower alkanoyl group, an aroyl group, a lower alkylthio group, a lower alkylsulfonyl group or a substituted or unsubstituted svdfamoyl group, E and D may be bonded together to form a ring which may contain one or two oxygen, nitrogen or sulfur atoms, T represents an interatomic bond, C(=0), C(=S), S(=0), S(=0)2, N(H)-C(=0), or N(H)-C(=S), and J and J' may be the same or different from each other and each represent a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkyloxy group or nitro group. 2. The sohd dispersion according to claim 1, wherein the water-soluble polymeric substance is one or more polymeric substance(s) selected from the group consisting of- celluloses or derivatives thereof selected from methylcellulose, hydroxypropylmethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose phthalate, hydroxypropylmethylcellulose acetate succinate, carboxymethylethylceUulose, carboxylmethylcellulose sodium, hydroxyethylceUulose and cellulose acetate phthalate! synthetic polymers selected from polyethyleneglycol, polyvinyl alcohol, poljrvinylpyrroHdone, polyvinylacetal diethylaminoacetate, aminoalkyl methacrylate copolymer E, aminoalkyl methacryl copolymer RS, methacrylic acid copolymer L, methacryUc acid copolymer LD, methacryUc acid copolymer S and carboxylvinyl polymer; and natural polymers or sugars selected from gum arable, sodium alginate, propylene glycol alginate, agar, gelatin, tragacanth, and xanthan gum. 3. The soHd dispersion according to claim 1, wherein the water-soluble polymeric substance is one or more polymeric substance(s) selected from the group consisting of methylcellulose, hydroxypropylmethylcellulose, hydroxypropylcellulose, polyethyleneglycol, polyvinyl alcohol and polyvinylpyrrohdone. 4. The sohd dispersion according to any one of claims 1 to 3, wherein the weight ratio of the compound of the formvJa (I) or pharmaceutically acceptable salts thereof to the water-soluble polymeric substance(s) is 1:0.1 to I-IOO. 5. The sohd dispersion according to any one of claims 1 to 3, wherein the weight ratio of the compound of the formula (l) or pharmaceutically acceptable salts thereof to the water-soluble polymeric substanceCs) is 1-0.25 to 1:20. 6. The sohd dispersion according to any one of claims 1 to 3, wherein the weight ratio of the compound of the formula (I) or pharmaceutically acceptable salts thereof to the water-soluble polymeric substance(s) is 1^0.5 to 1:10. 7. The solid dispersion according to any one of claims 1 to 6, wherein the phenylalanine compound of the formula (I) or pharmaceutically acceptable salts thereof are, in the formula (l), the compound or pharmaceutically acceptable salts thereof wherein Rl represents a methyl group or an ethyl group; and R2, R3, and R4 represent a hydrogen atom, a halogen atom, a hydroxyl group, a substituted low alkyl group, a substituted lower alkenyl group, a substituted lower alkynyl group, a heteroaryl group, a hydroxylower alkyl group, an amino group substituted with a lower alkyl group, or a carbamoyl group substituted with a lower alkyl group, wherein the substituents in the substituted low alkyl group, the substituted lower alkenyl group and the substituted lower alkynyl group include an amino group, an amino group substituted with a lower alkyl group, a carboxyl group, a lower alkoxycarbonyl group, a cyano group, a lower alkylthio group, and a lower alkylsulfonyl group. 8. The soHd dispersion according to any one of claims 1 to 6, wherein the compound of the formula (l) or pharmaceutically acceptable salts thereof are the following compound (A) or pharmaceutically acceptable salts thereof. 9. A solid dispersion pharmaceutical preparation which is prepared by processing the soHd dispersion according to any one of claims 1 to 8. 10. A solid dispersion pharmaceutical preparation containing the soHd dispersion according to any one of claims 1 to 8 and a foaming agent(s). 11. A solid dispersion pharmaceutical preparation which is prepared by coating a core component containing the solid dispersion according to any one of claims 1 to 8 with a coating agent(s). 12. The solid dispersion pharmaceutical preparation according to claim 11, wherein the coating agent is one or more coating agent(s) selected from the group consisting of aminoalkyl methacrylate copolymer E, hydroxypropylmethylcellulose, methylceUulose, methylhydroxyethylcellulose, opadry, carmellose calcium, carmellose sodium, polyvinylpyrrohdone, poljrvinyl alcohol, dextrin, puUulan, gelatin, agar and gum Arabic. 13. A method for producing a solid dispersion which comprises the steps of dissolving or dispersing the compound of the formula (l) or pharmaceutically acceptable salts thereof in an organic solvent(s) together with a water-soluble polymeric substance(s), and then removing the organic solvent(s). 14. A method for producing a solid dispersion which comprises the steps of dissolving or dispersing the compound of the formula (l) or pharmaceutically acceptable salts thereof in a water-soluble polymeric substanceCs) under heating, and then cooling the mixture. 15. A method for producing a solid dispersion which comprises the steps of dissolving or dispersing the compound of the formula (l) or pharmaceutically acceptable salts thereof in a water-soluble polymeric substanceCs) under heating and under pressure, and then cooling the mixture. 16. A method for producing a solid dispersion which comprises the steps of mixing the compound of the formula (l) or pharmaceutically acceptable salts thereof together with a water-soluble polymeric substanceCs), and then grinding the mixture. 17. The method for producing the sohd dispersion according to claim 13, wherein the organic solvent is one or more organic solventCs) selected from halogenated hydi'ocarbons and alcohols. 18. A solubilized pharmaceutical preparation containing a solubilizer(s) and the compound of the formula (l) according to claim 1 or pharmaceutically acceptable salts thereof. 19. A solubihzed pharmaceutical preparation containing a solubLlizer(s), a 3urfactant(s) and the compound of the formula (l) according to claim 1 or pharmaceutically acceptable salts thereof. 20. The solubilized pharmaceutical preparation according to claims 18 or 19 containing a pharmaceutically acceptable OLI(S). 21. The solubilized pharmaceuticcd preparation according to any one of claims 18 to 20, wherein the solubilizer is selected from the gi'oup consisting of propylene carbonate, propylene glycol, polyethyleneglycols, triethyl citrate, glycerin monocaprate, and glycerin monooleate. 22. The solubihzed pharmaceutical preparation according to claims 19 or 20, wherein the surfactant is a polyoxyethylene surfactant(s). 23. The solubilized pharmaceutical preparation according to claim 20, wherein the pharmaceutically acceptable oil is selected from the group consisting of glycerin esters of fatty acids having 6 to 18 carbon atoms, polyoxy ethylene hydrogenated caster oils, sorbitan fatty acid esters, and propylene glycol fatty acid esters. 24. The solubilized pharmaceutical preparation according to claim 20, wherein the surfactant is a polyoxy ethylene surfactant(s); and the pharmaceutically acceptable oil is glycerin esters of fatty acids having 6 to 18 carbon atoms, polyoxyethylene hydrogenated caster oils, sorbitan fatty acid esters, or propylene glycol fatty acid esters. 25. The solubilized pharmaceutical preparation according to any one of claims 18 to 24, wherein the compound of the formula (l) according to claim 1 or pharmaceutically acceptable salts thereof are the compound of the formula (A) according to claim 8 or pharmaceutically acceptable salts

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