Indian Patents. 233149:"A NOVEL BENZENESULPHONAMIDE COMPOUND"

Title of Invention	"A NOVEL BENZENESULPHONAMIDE COMPOUND"
Abstract	The invention relates to novel benzenesulphonamide compounds, as defined in formula (I) and the description, the method for preparation and therapeutic use thereof.

Full Text	Benzenesuiphonamide derivatives, method for production and use thereof for treatment of pain The present invention relates to novel benzenesulphonamide compounds, their method of preparation and pharmaceutical composition comprising these compounds; These novel compounds are useful for treatment of pain. Prior art Compounds are already known whose structure includes a group of benzenesulphonamide type. For example, through EP 236 163 and EP 236 164, N-a-arylsulphonylaminoacyl-p-amidino-phenyl-alaninamide derivatives may be cited which are selective thrombin inhibitors and can be used as anti-thrombotics. Also, from EP 614 911, compounds are known having a fairly close structure to the preceding compounds, simultaneously containing an arylsulphamoyl group and a substituted phenylamidine group, which have the property of binding to receptors of the Y neuropeptide and can be used to treat hypertension, angina pectoris, atherosclerosis, depression, anxiety, inflammation, allergy or excess fat. EP 558 961 also suggests the use of arylsulphonamide-type compounds of substituted amino acids for the treatment of thrombosis on account of their anticoagulant properties. Studies on the anti-thrombotic properties of compounds containing an arylsulphonamide group in their structure and a phenylamidine group have also been published in Pharmazie 1984 vol. 39 (5) pages 315-317 and Pharmazie 1986 vol. 41(4) p 233-235. In the same field of pharmacological activity WO 92/16549 Al describes derivatives of phenylalanine comprising an arylsulphonamide group, which are proteinase inhibitors, in particular thrombin inhibitors. Also, according to WO 97/25315, compounds are known having N(arylsulphonyl)amino-acid structure, which can be used to treat inflammatory diseases. Among the prior art documents proposing structural elements of arylsulphonamide type, mention may be made of WO 96/40639, WO 97/24349, WO 98/03503, WO 98/24783 and WO 99/00387, pertaining to antagonist compounds of the B2 receptor of bradykinin. Antagonist compounds of the B1 receptor of bradykinin, whether peptide or nonpeptide, are also known through documents WO 01/05783, WO 02/099388 and WO 97/09346. Object of the invention The invention concerns novel compounds comprising the substituted benzenesulphonamide chain, said compounds being notably useful as active ingredients in medicinal products intended to treat pain, in particular hyperalgesia and major algesia. Description According to the present invention, as novel industrial product a compound is proposed of benzenesulphonamide type, characterized in that it is selected from the group consisting of: a) compounds of formula: (Formula Removed) in which - R1, R2, R3, R4 each independently represent one or more atoms or groups of atoms selected from a hydrogen atom, halogens, C1-C3 alkyl groups, C1-C3 alkoxy groups, CF3 or OCF3 groups, - Ra represents a C1-C4 alkyl group, - Y represents a saturated C2-C5 alkylene group, optionally interrupted by an oxygen atom, an unsaturated C2-C4 alkylene group, or a —CH2-CO-NH-CH2- group, - X represents CH or a nitrogen atom, - p represents 2 or 3, - A represents a single bond, a nitrogen atom optionally substituted with a methyl group, or a straight or branched C1-C5 alkylene group, optionally hydroxylated or of which one of the carbon atoms is oxidized into a ketone function, provided that A and X together do not represent a nitrogen atom, - B represents a nitrogen-containing heterocycle or an amine group optionally substituted with one or two C1-C4 alkyl groups, b) the addition salts of the above formula I compounds with an acid. The invention, when the formula I compounds comprise a centre of assymetry, also concerns each of the optical isomers either pure or mixed, and their respective salts or salt mixtures. According to the invention, a method is also proposed to prepare formula I compounds and their addition salts. The use is also put forward of a substance selected from the formula I compounds and their non-toxic addition salts for the preparation of a medicinal product which can be used in human or animal therapy intended for the prevention or treatment of pain-related pathologies, in particular hyperalgesia subsequent to an inflammatory condition, or major algesia connected with other pathological conditions such as cancer for example. Detailed description In formula I, by alkyl group is meant a straight, branched or cyclized hydrocarbon chain. A C1-C3 alkyl group is notably a methyl, ethyl, propyl, cyclopropyl or 1-methyl-ethyl group. A C1-C4 alkyl group, in addition to the above-cited examples, will notably comprise butyl, 1-methylpropyl and 1,1-dimethylethyl groups. By C1-C3 alkoxy group is meant an OR group in which R is a C1-C3 alkyl group, the term alkyl having the meaning given above. Said group is for example a methoxy, ethoxy, propoxy or 1-methylethoxy group. By saturated C2-C5 alkylene group is meant a —(CH2)~- group in which n is 2, 3, 4 or 5 if it is a straight group or, for example a —CH(CH3)-CH2-CH2- or —C(CH3)2-CH2- group if it is a branched group. By an alkylene group interrupted by an oxygen atom is meant for example the groups —CH2-CH2-O-CH2-, -CH2-O-CH2-CH2- or even -CH2-CH2-O-CH2-CH2-. By unsaturated C2-C4 alkylene group, is meant a group comprising 2 to 4 carbon atoms of which 2 consecutive atoms are bound by an ethylene bond, for example the groups —CH2-CH=CH-CH2-, -CH=CH-CH2-, -CH =C(CH3)-CH2-, CH2-CH =CH- or —CH =CH-CH(CH3)-. By halogen is meant an atom of fluorine, chlorine or bromine and preferably a fluorine or chlorine atom. By alkylamino or dialkylamino groups is meant the NH(R) or N(R)2 groups in which R is a C1-C4 alkyl group, the term alkyl having the -neaning given above. By nitrogen-containing heterocycle is notably meant the azetidine, pyrrolidine, morpholine, piperidine, piperazine, N-(C1-C.4)alkylpiperidine, N ~C1-C4)alkylpiperazine, quinuclidine, tropane, E~)alkylhomopiperazine, aminopyridine and N-(C1-C4)alkylimidazole rings. By addition salts is meant the addition salts obtained by reaction of a formula I compound containing at least one basic function in its nonsalified form, with a mineral or organic acid. Preferably, these are pharmaceutically acceptable addition salts. Among the mineral acids suitable for salifying a basic compound of formula I, preference is given to hydrochloric, hydrobromic, phosphoric and sulphuric acids. Among the organic acids suitable for salifying a basic compound of formula 1, preference is given to methanesulphonic, benzenesulphonic, toluenesulphonic, maleic, fumaric, oxalic, citric, tartaric, lactic and trifluoroacetic acids. Among the formula I compounds, preference is given to those which meet at least one of the following conditions: - R1 represents hydrogen, a halogen, a C1-C3 alkyl group or C1-C3 alkoxy group; - R2 represents a halogen, a C1-C3 alkyl group or CF3 group; - R3 represents hydrogen, a halogen, a C1-C3 alkyl group or C1-C3 alkoxy group; - R4 represents hydrogen or a C1-C3 alkyl group; - R.3 represents a methyl group; - Y represents a saturated C2-C5 alkylene group, optionally interrupted by an oxygen atom; - p represents 2; A represents a single bond or a straight or branched C1-C5 alkylene group; B represents an azetidinyl, pyrrolidinyl, morpholinyl, piperidinyl, piperazinyl, N-(C1-Q)alkylpiperidinyl, N-(C1-C4)alkylpiperazinyl, quinuclidinyl, tropanyl or N-(C1-C4)alkylhomopiperazinyl group. Particular preference is given to formula I compounds which meet at least one of the following conditions: - R1 represents a C1-C3 alkoxy group; - R2 and R3 each represent a C1-C3 alkyl group, preferably a methyl group at position 2,6 on the aromatic ring; - R~ represents hydrogen; - Y represents a C3-C5 alkylene group interrupted by an oxygen atom, preferably a —CH2-CH2-O-CH2- group; - B represents a piperidinyl, N-(C1-C4)alkylpiperidinyl, or N-(C1-C4) alkylpiperazinyl group. Preference is also given to compounds of formula Ia: (Formula Removed) in which - R1, R2, R3 each independently represent one or more atoms or groups of atoms selected from a hydrogen atom, halogens, C1-C3 alkyl groups, C1-C3 alkoxy groups, CF3 or OCF3 groups, - Y represents a saturated C2-C5 alkylene group, optionally interrupted by an oxygen atom, an unsaturated C2-C4 alkylene group or a —CH2-CO-NH-CH2- group, - A represents a single bond or a (CH2)m group, - R represents a saturated nitrogen-containing heterocycle, notably selected from the pyrrolidine, morpholine, piperidine, quinuclidine, tropane rings, or a tertiary amine group, notably a dialkylamino group, - m and p each independently represent 2 or 3. Preference is also given to compounds of formula Ib: (Formula Removed) in which - R1, R2, R3 each independently represent one or more atoms or groups of atoms selected from a hydrogen atom, halogens, C1-C3 alkyl groups, C1-C3 alkoxy groups, CF3 or OCF3 groups, - Y represents a saturated C2-C5 alkylene group, optionally interrupted by an oxygen atom, an unsaturated C2-C4 alkylene group, or a —CH2-CO-NH-CH2- group, - A represents a single bond or a saturated C1-C5 alkylene group, optionally hydroxylated, - R represents a saturated nitrogen-containing heterocycle notably selected from the N-methylpiperazine, N-methylpiperidine rings, or a tertiary amine group, notably a dialkylamino group. According to the invention, a general method is put forth for preparing formula I compounds or their addition salts, comprising the steps consisting of: a) allowing an acid of formula: (Formula Removed) in which R1, R2, R3, R4 each independently represent one or more atoms or groups of atoms selected from a hydrogen atom, halogens, C1-C3 alkyl groups, C1-C3 alkoxy groups, CF3 or OCF3 groups, R8 represents a C1-C4 alkyl group, Y represents a saturated C2-C5 alkylene group, optionally interrupted by an oxygen atom, an unsaturated C2-C4 alkylene group, or a —CH2-CO-NH-CH2-group, to react with a nitrogen-containing heterocycle of formula: (Formula Removed) in which X represents CH or a nitrogen atom, p represents 2 or 3, A represents a single bond, a nitrogen atom optionally substituted with a methyl group (if X does not also represent a nitrogen atom), or a straight or branched C1-C5 alkylene group, optionally hydroxylated or of which one of the carbon atoms is oxidized into a ketone function, B represents a nitrogen-containing heterocycle or an amine group optionally substituted with one or two C1-C4 alkyl groups, on the understanding that if a non-substituted nitrogen atom is present, this nitrogen atom is protected by an amino-protecting group such as a Boc group (1, 1-dimethylethoxycarbonyl) or Cbz group (phenylmethoxycarbonyl) for example, in a solvent such as tetrahydrofuran, dichloromethane or dimethylformamide for example, in the presence of activators such as EDCI (1-(3-dimethylami nopropyl)-3-ethylcarbodiimide), DIC (diisopropylcarbodiimide) or HOAT (1-hydroxy-7-azabenzotriazOle), at a temperature generally lying between ambient temperature and the boiling point of the solvent, for approximately 2 to 15 hours, to obtain the amide of formula: (Formula Removed) in which R1, R2, R3, R4, Ra, Y, p, X, A and B maintain the same meaning as in the starting products, b) if necessary, removing the amino-protecting groups, for example through the action of trifluoroacetic acid in the presence of anisole if said amino-protecting group is a Boc group, or by catalytic hydrogenation if the protecting group is a Cbz group, c) if necessary, obtaining an addition salt of the formula I compound with a mineral or organic acid, following usual procedures known to persons skilled in the art. This general method for preparing an amide function starting with a carboxylic acid and an amine may be modified to use activators immobilized on an insoluble resin, for example resins having a polystyrene skeleton supporting carbodiimide functions. As a variant of the above-described general method, the acid of formula II may be converted intermediately into an acid chloride of formula ha, (Formula Removed) notably through the action of a chlorinating agent such as oxalyl chloride or thionyl chloride, said acid chloride then being allowed to react with the nitrogen-containing heterocycle of formula III using a conventional reaction conducted in a solvent and preferably in the presence of an aprotic organic base such as triethylamine or pyridine for example, to obtain the compound of formula I. The acids of formula II in which Y represents a -CH2-CH2-O-CH2-group may be prepared following a method consisting of: a) allowing a benzenesulphonyl chloride of formula: (Formula Removed) in which R1, R2, R3 and R4 each independently represent a hydrogen or halogen atom, a C1-C3 alkyl group, a C1-C3 alkoxy group, CF3 or OCF3 group, to react with an aminoalcohol of formula: in which P.8 represents a C1-C2 alkyl group, in a solvent such as dichloromethane for example, in the presence of an aprotic organic base such as triethylamine or pyridine for example, at a temperature lying between approximately 0 and 50 0C, for approximately 1 to 3 hours, to obtain the sulphonamide of formula: (Formula Removed) in which R1, R2, R3, R4 and P.8 remain unchanged, b) allowing the compound of formula V obtained above to react with an ester of bromacetic acid, preferably the t-butyl ester, in the presence of a base such as sodium hydroxide for example and in a phase-transfer promoting medium containing quarternary ammonium salts, in a mixture of solvents such as water and toluene, at a temperature lying between approximately 0 0C and 40 0C for approximately 1 to 5 hours, to obtain the ester of formula: (Formula Removed) c) hydrolysing the ester of formula VI, for example through the action of trifluoroacetic acid, the reaction being conducted in a solvent such as dichloromethane, at a temperature lying between approximately 0 0C and 50 0C for approximately 1 to 6 hours, to obtain the acid of formula II: (Formula Removed) in which R1, R2, R3, P.4 and Ra remain unchanged and Y represents a -CH2-CH2-O-CH2- group. As a variant of the general method, the formula I compounds may be obtained by successively performing the steps consisting of: a) allowing an acid compound of formula: (Formula Removed) in which Ra represents a C1-C4 alkyl group, Y represents a saturated C2-C5 alkylene group, optionally interrupted by an oxygen atom, and Za represents an amino-protecting group such as a benzyl group for example, to react with a nitrogen-containing heterocycle of formula: (Formula Removed) in which X represents CH or a nitrogen atom, p represents 2 or 3, A represents a single bond, a nitrogen atom optionally substituted with a methyl group (if X does not also represent a nitrogen atom), or a straight or branched C1-C5 alkylene group optionally hydroxylated or of which one of the carbon atoms is oxidized into a ketone function, B represents a nitrogen-containing heterocycle or an amine group optionally substituted with one or two C1-C4 alkyl groups, on the understanding that, should a non-substituted nitrogen atom be present, this nitrogen atom is protected by a different amino-protecting group to the amino-protecting group used for acid compound VII, such as a Boc group (1,1-dimethylethoxycarbonyl), in a solvent such as tetrahydrofuran or dichloromethane or dimethylformamide for example, in the presence of activators such as EDCI (1-(3-dimethylaminopropyl)-3-ethylcarbodiimide), DIC (diisopropylcarbodiimide) or HOAT (1-hydroxy-7-azabenzotriazole) for example, at a temperature generally lying between ambient temperature and the boiling point of the solvent, for approximately 2 to 15 hours, to obtain the amide of formula: (Formula Removed) in which Za, Ra, Y, p, X, A and B maintain the same meaning as in the starting compounds, b) removing the Za amino-protecting group, for example by catalytic hydrogenation if Za is a benzyl group, to obtain the secondary amine of formula: (Formula Removed) in which Ra, Y, p, X, A and B maintain the same meaning as in the preceding compound, c) allowing this secondary amine IX to react with a benzenesulphonyl chloride of formula: (Formula Removed) in which R1, R2, R3 and R4 each independently represent a hydrogen or halogen atom, a C1-C3 alkyl group or a C1-C3 alkoxy group, CF3 or OCF3 group, in a solvent such as dichloromethane for example, in the presence of an aprotic organic base such as triethylamine or pyridine for example, at a temperature lying between approximately 0 and 50 0C, for approximately 1 to 3 hours, to obtain the sulphonamide of formula: (Formula Removed) in which R1, R2, R3, R4, Ra, Y, p, X, A and B maintain the same meaning as in the starting compounds, d) if necessary, removing the amino-protecting groups, for example through the action of trifluoroacetic acid in the presence of anisole if said amino-protecting group is a Boc group, e) if necessary, obtaining an addition salt of the formula I compound with a mineral or organic acid. As a variant of the above method, step a) to form the amide bond may be conducted by first forming the acid chloride of formula VII, for example through the action of oxalyl chloride or thionyl chloride in an anhydrous aprotic solvent, followed by reaction of the acid chloride obtained with the formula III amine as described above, in a solvent and for example in the presence of an aprotic base such as triethylamine. The heterocyclic derivatives of formula III are known compounds, commercially available or described in the literature, or may be prepared using methods known to persons skilled in the art, for example through a reductive amination reaction between piperazine or homopiperazine and a ketone, for example in the presence of titanium isopropoxide then a reaction with a reducing agent such as sodium cyanoborohydride, or, if piperidine derivatives are used, through catalytic hydrogenation of pyridine-homologous compounds. The invention will be more readily understood with the help of examples of preparation of compounds and the results of pharmacological tests demonstrating the therapeutic usefulness of these compounds. These examples are non-limiting and cannot be interpreted as limiting the scope of the invention. Among the abbreviations used in the description, M means mole, mM means millimole (10~ mole). THE means tetrahydrofurane, DCM means dichloromethane, DMF means dimethylformamide, TFA means trifluoroacetic acid. For compounds having a centre of assymetry, the absence of any particular indication means that the compound is in the form of the racemic mixture. In the spectral data for nuclear magnetic resonance, chemical shifts are indicated with reference to TMS (tetramethylsilane). PREPARATION I N(2-hydroxyethyl)-4- methoxy- N, 2,6-trimethylbenzene-suiphonamide A solution of 1.76 g (23.4 mM) of 2-(methylamino)ethanol is prepared in 100 ml of DCM and 5.4 g (53 mM) of triethylamine are added. The mixture is cooled to 0 0C and a solution of 5 g (21.3 mM) of 2,6 dimethyl4-methoxybenzenesulphonyl chloride in 50 ml of DCM is added progressively. The mixture is then agitated for 3 hours at ambient temperature, and then poured over 50 ml of 0.5 N hydrochloric acid. The organic phase is separated and then washed with water, dried over magnesium sulphate and concentrated under reduced pressure. 5.8 g of the compound sought after are thus obtained as a colourless oil (yield = 100 0/a) 'H NMR (300 MHz, DMSO) 8: 6.80 (s, 2H) ; 4.70 (t, 1H) ; 3.80 (5, 3H) ; 3.48 (q, 2H); 3.09 (t, 2H); 2.69 (s, 3H); 2.54 (s, 6H). PREPARATION II [2-([(4-methoxy-2,6-dimethylphenyl)sulphonyl]methylamino]-ethoxyjacetic acid, 1,1-dimethylethyl ester A solution of 4.85 g (17.7 mM) of the compound obtained according to preparation I is prepared in 100 ml of toluene and 1.62 g of tetrabutylammonium chloride are added. The mixture is cooled to 0 0C and 100 ml of 350/a sodium hydroxide are then added, then, progressively, 3.95 ml (26.6 mM) of t-butyl bromacetate are added. The mixture is agitated at ambient temperature for 2 hours and the organic phase is then separated by decanting, and washed with water to neutral pH and then dried over sodium sulphate. After concentration under reduced pressure, an oil is obtained which is purified by silica gel chromatography in eluting with the aid of a cyclohexane/ethyl acetate mixture (75/25; v/v). 6.5 g of the compound sought after are thus obtained as a colourless oil (yield = 94 0/~~) 'H NMR (250 MHz, DMSO) 8: 6.80 (s, 2H) ; 3.89 (s, 2H) ; 3.80 (s, 3H); 3.56 (t, 2H); 3.21 (t, 2H); 2.71 (s, 3H); 2.53 (s, 3H) ; 1.41 Cs, 9H). PREPARATION III [2-[[(4-methoxy-2,6-dimethylphenyl)sulphonyl]methylami no]ethoxyjacetic acid 6.4 g (16.5 mM) of the ester obtained according to preparation II are dissolved in 80 ml of DCM, and 8 ml of trifluoroacetic acid are added. The mixture is agitated at ambient temperature for 4 hours, and then concentrated under reduced pressure. The residue from evaporation is taken up into solution in 100 ml of iN sodium hydroxide and the solution obtained is washed twice with 30 ml of ethyl acetate, and then acidified with an N solution of hydrochloric acid and extracted with twice 80 ml of ethyl acetate. The organic phase is washed with water, dried over sodium sulphate and concentrated under pressure. The acid sought after is thus obtained as an oil which crystallises (yield = 95 0/a). M.Pt. = 82 0C Example 1 1-[[2-[[(4-methoxy-2,6- dimethylphenyl)sulphonyl]methylamino]-ethoxy]acetyl]-4-[2-(1-pyrrolidinyl)ethyl] piperazine, bis-trifluoroacetate 482 mg cyclohexyldiimide grafted polystyrene resin are placed in 5 ml of THF for 20 minutes and 100 mg (0.31 mM) of the acid obtained according to preparation III in solution in 2 ml of THF, 37 mg (0.20 mM) of 1-[2-(1-pyrrolidinyl)ethyl]piperazine and 2 mg of HOAT (1-hydroxy-7-azabenzotriazole), are then added. The mixture is agitated for 4 hours at ambient temperature and then filtered. The resin is rinsed with 4 ml of THF which is added to the filtrate. The filtrate is then agitated with 50 mg of Amberlite IRA 400 resin (as 0H), for 3 hours. After filtration, the resin is rinsed with 3 ml of THF which is added to the filtrate. This filtrate is then treated with 100 mg of isocyanate grafted polystyrene resin for 1 hour. The resin is separated off by filtration and the solution is concentrated under reduced pressure. The residue (63 mg) is purified by reverse phase chromatography on an X Terra Prep MS C18 column (eluent A : water + 0.05 0/0 TFA, eluent B : acetonitrile + 0.05 0/0 TFA, gradient 10 o/o B (t = 0 to 2 minutes) 60 0/0 B (t = 2 to 17 minutes) 100 % B (t = 17 minutes to 18 minutes); flow rate = 25 mI/mn; UV detection from 120 to 260 nm. The purified product is taken up into 1 ml of acetonitrile and it is mixed with 6 ml of a 10/0 solution of trifluoroacetic acid in water. The solution obtained is then freeze-dried and 19 mg of the salt sought after are obtained as a yellow oil (yield = 13 Gb). 'H NMR (300 MHz, CD3CN) 8: 6.74 (s, 2H) ; 4.09 (s, 2H) ; 3.96 (s, 3H) 3.70 (in, 1H) ; 3.59 (t, 2H) ; 3.48 (t, 2H) ; 3.33 (in, 5H) ; 3.19 (t, 2H) 3.00 (in, 4H); 2.72 (s; 3H); 2.56 (5, 6H) ; 2.04 (in, 4H). PREPARATION IV [2-([(2,4,6-trimethylphenyl)sulphonyl]methylami nojethoxy]acetic acid, 1,1-dimethylethyl ester In operating analogously to preparation II, starting with N-(2-hydroxyethyl)-N,2,4,6-tetramethylbenzenesulphonamide, the ester sought after is obtained as a beige oil (yield = 98 %). 'H NMR (250 MHz, DMSO) 8: 7.06 (s, 2H) ; 4.01 (s, 2H) ; 3.58 (t, 2H) 3.25 (t, 2H); 2.72 Cs, 3H); 2.51 (s, 6H); 2.27 (s, 3H) ; 1.43 (s, 9H). PREPARATION V [2-[[(2,4,6-trimethylphenyl)sulphonyl] methylaminojethoxy]acetic acid In operating analogously to preparation III, starting with the compound obtained according to preparation IV, the product sought after is obtained as a beige solid (yield = 83 %). M.Pt. = 58 0C PREPARATION VI N-ethyl-N-(2-hydroxyethyl)-4-methOXy-2,6-dinlethylbenZene suiphonamide In operating analogously to preparation I, starting with 2-(ethylamino)ethanol, the product sought after is obtained as a yellow oil (yield = 990/a). 'H NMR (250 MHz, DMSO) 8: 6.80 (s, 2H) ; 4.69 (t, 1H) ; 3.80 (s, 3H) 3.38 (in, 2H); 3.14 (5, 2H). PREPARATION VII (2-[[(4-methoxy-2,6-dimethylphenyl)sulphonyl]ethylaminO]-ethoxy]acetic acid, 1, 1-dimethylethyl ester In operating analogously to preparation II, starting with the compound obtained according to preparation VI, the product sought after is obtained as a colourless oil (yield = 790/a). 'H NMR (250 MHz, DMSO) 8: 6.79 (s, 2H) ; 3.86 (s, 2H) ; 3.79 (s, 3H) 3.47 (t, 2H); 3.24 (in, 4H) ; 2.53 (s, 6H); 1.40 (s, 9H); 1.00 (t, 3H). PREPARATION VIII [2- [[(4-methoxy-2,6-dimethylphenyl)suIphonyI]ethylamiflO]-ethoxyjacetic acid In operating analogously to preparation III, starting with the compound obtained according to preparation VII, the product sought after is obtained as a white solid (yield = 88Gb). 'H NMR (250 MHz, DMSO) 8: 6.79 (s, 2H) ; 3.89 (s, 2H) ; 3.79 (s, 3H) 3.48 (t, 2H) ; 3.24 (q, 2H); 3.21 (t, 2H) ; 2.53 (s, 6H); 1.00 (t, 31-i). PREPARATION IX N-(2-hydroxyethyl)-4-methoxy-2,6-dimethyl-N-( 1-methylethyl)benzene-sulphonamide In operating analogously to preparation I, starting with 2-[(1-inethylethyl)amino]ethanol, the product sought after is obtained as a colourless oil (yield = 58%). 'H NMR (300 MHz, DMSO) 8: 6.80 (s, 2H) ; 4.68 (t, 1H) ; 3.80 (s, 3H); 3.73 (quin, 1H) ; 3.27 (dt, 2H) ; 3.20 (q, 2H); 3.12 Ct, 2H) ; 2.53 (5, 6H) 1.06 (d, 6H) ; 0.99 (t, 3H). PREPARATION X [2-[[(4-methoxy-2,6-dimethylphenyl)sulphonyl](1-methylethyl)amino]-ethoxy]acetic acid, 1,1-dimethylethyl ester In operating analogously to preparation II, starting with the compound obtained according to preparation IX, the product sought after is obtained as a colourless oil (yield = 950/o). 'H NMR (250 MHz, DMSO) 8: 6.80 (s, 2H) ; 3.86 (s, 2H) ; 3.80 (s, 3H) 3.74 (quin, 1H); 3.82 (in, 2H) ; 3.26 (in, 2H); 2.53 (s, 6H) ; 1.40 (s, 9H) 1.07 (d, 6H). PREPARATION XI [2-[[(4-methoxy-2,6-dimethylphenyl)sulphonyl]( 1-methylethyl)amino]-ethoxy]acetic acid In operating analogously to preparation III, starting with the compound obtained according to preparation X, the product sought after is obtained as a white solid (yield = 850/a). M.Pt. = 96 0C PREPARATION XII N-cyclopropyl- N-(2-hydroxyethyl)-4-methoxy-2,6-dimethylbenzene-sulphonamide In operating analogously to preparation I, starting with 2-(cyclopropylamino)ethanol, the product sought after is obtained as a white solid (yield = 770/a). M.Pt. = 58GC PREPARATION XIII [2-[cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulphonyl] aminojethoxyjacetic acid, 1,1-dimethylethyl ester In operating analogously to preparation II, starting with the compound obtained according to preparation XII, the product sought after is obtained as a colourless oil (yield = 84%). 'H NMR (300 MHz, DMSO) 8: 6.80 (s, 2H) ; 3.98 (s, 2H) ; 3.80 (s, 3H) 3.69 (t, 2H) ; 3.44 (t, 2H) ; 2.50 (s, 6H) ; 2.47 (in, 1H) ; 1.42 (s, 9H) 0.48 (in, 2H); 0.16 (in, 2H). PREPARATION XIV [2-[cyc!opropyl[(4-methoxy-2,6-dimethyl phenyl)sulphonyl]aminojethoxyjacetic acid In operating analogously to preparation III, starting with the compound obtained according to preparation XIII, the product sought after is obtained as a white solid (yield = 85Gb). M.Pt. = 1000C PREPARATION XV 2,6-dichloro-4-methoxybenzenesulphonyl chloride and 2,4-dichloro-6-methoxybenzenesulphonyl chloride A solution is prepared of 15 g (84.7 mM) of 3,5-dichloroanisole in 8 ml of thionyl chloride that is cooled to — 100C, and 6 ml (90 mM) of chlorosulphonic acid are then added dropwise. The reaction mixture is then agitated for 3 hours at ambient temperature, and then poured over a mixture of ice and ethyl acetate. The organic phase is separated, dried over magnesium sulphate and concentrated under reduced pressure. The residue from evaporation is used, without other purification, in the next step. PREPARATION XVIa 2,6-dichloro-N-(2-hydroxyethyl)-4-methoxy-N-methyl-benzenesulphonamide PREPARATION XVIb 2,4-dichioro- N-(2-hydroxyethyl)-6-methoxy-N-methyl-benzenesulphonamide In operating analogously to preparation I, starting with the sulphonyl chlorides obtained according to preparation XV, the products sought after are obtained as white solids, after separation of the compounds and purification by silica gel chromatography, in eluting with the aid of a toluene/isopropanol mixture (95/5 ;v/v). PREPARATION XVIa (yield = 130/0) : M..Pt. = 470C PREPARATION XVIb (yield = 480/o) : M.Pt. = 1000C PREPARATION XVII [2-II(2,6-dichloro-4-methoxyphenyl)sulphonyl]methylamino]-ethoxyjacetic acid, 1, 1-dimethylethyl ester In operating analogously to preparation II, starting with the compound obtained according to preparation XVIa, the product sought after is obtained as a colourless oil (yield = S20bo). 'H NMR (300 MHz, DMSO) 8: 7.24 (s, 2H) ; 3.94 (s, 2H) ; 3.87 Cs, 3H) 3.60 (t, 2H); 3.39 t, 2H) ; 2.90 (s, 3H); 1.41 (s, 9H). PREPARATION XVIII [2-[[(2,6-dichloro-4-methoxyphenyl)sulphonyljmethylamino]-ethoxy] acetic acid In operating analogously to preparation III, starting with the compound obtained according to preparation XVII, the product sought after is obtained as a white solid (yield = 94%). M.Pt. = 950C PREPARATION XIX [2-I [(2,4-dichloro-6-methoxyphenyl)sulphonyl]methylamino]ethoxy]acetic acid, 1,1-dimethylethyl ester In operating analogously to preparation II, starting with the compound obtained according to preparation XVIb, the product sought after is obtained as an oil which is used, without other purification, in the next step. PREPARATION XX [2-[[(2,4-dichloro-6-methoxyphenyl)sulphonyl]methylamino] ethoxyjacetic acid In operating analogously to preparation III, starting with the compound obtained according to preparation XIX, the product sought after is obtained as a white solid (yield = 760bo). M.Pt. = 740C PREPARATION XXI 2,4-dichloro-N-(2-hydroxyethyO-3,N-dimethyl-benzenesulphonamide In operating analogously to preparation I, starting with 2,4-dichloro-3-inethylbenzenesulphonyl chloride, the product sought after is obtained as a colourless oil. PREPARATION XXII [2-[[(2,4-dichloro-3- methylphenyl)sulphonyl]methylamino]ethoxy] acetic acid, 1,1-dimethylethyl ester In operating analogously to preparation II, starting with the compound obtained according to preparation XXI, the product sought after is obtained as a colourless oil (yield = 87Gbo). 'H NMR (300 MHz, DMSO) 8: 7.83 (d, 1H) ; 7.63 (d, 1H) ; 3.93 (s, 2H); 3.59 Ct, 2H); 3.39 (t, 2H); 2.91 (s, 3H) ; 2.49 (5, 3H); 1.41 (5, 9H). PREPARATION XXIII [2-[ [(2,4-dichloro-3- methylphenyl)sulphonyl]methylaminoJethoxy]acetic acid In operating analogously to preparation III, starting with the compound obtained according to preparation XXII, the product sought after is obtained as a colourless oil (yield = 100%). 'H NMR (300 MHz, DMSO) 8:12.50 (in broad, 1H) ; 7.84 (d, 1H) ; 7.63 (d, 1H) ; 4.02 (s, 2H) ; 3.61 (t, 2H) ; 3.40 Ct, 2H) ; 2.91 (s, 3H) ; 2.51 (s, 3H). PREPARATION XXIV N-(2- hydroxyethyl)- N-methyl-2-(trifluoromethyl)benzene-suiphonamide In operating analogously to preparation I, starting with 2-(trifluoromethyl)benzenesulphonyl chloride, the product sought after is obtained as a yellow oil (yield = 990bo). 'H NMR (250 MHz, DMSO) 8: 8.02 (in, 2H) ; 7.88 (in, 2H) ; 4.84 (t, 1H); 3.55 (q, 2H); 3.30 (t, 2H); 2.93 (s, 3H). PREPARATION XXV [2-[[[2-(trifiuoromethyl)phenyl]sulphonyl]methylamino]-ethoxyjacetic acid, 1, 1-d imethylethyl ester In operating analogously to preparation II, starting with the compound obtained according to preparation XXIV, the product sought after is obtained as a yellow oil (yield = 670bo). 'H NMR (250 MHz, DMSO) 8: 8.02 (in, 2H); 7.98 (in, 2H); 3.97 (s, 2H); 3.63 (t, 2H) ; 3.44 Ct, 2H); 2.95 (s, 3H); 1.42 (s, 9H). PREPARATION XXVI [2-[[ [2-(trifluoromethyl)phenyl]sulphonyl]methylamino]-ethoxy]acetic acid In operating analogously to preparation III, starting with the compound obtained according to preparation XXV, the product sought after is obtained as a colourless oil (yield = 780h). 'H NMR (250 MHz, DMSO) 8: 8.02 (in, 2H) ; 7.86 (in, 2H); 4.01 (s, 2H) 3.65 (t, 2H) ; 3.45 (t, 2H) ; 2.95 Cs, 3H). PREPARATION XXVII [2-~[4-methoxy-2-(trifiuoromethyI)phenyI]suIphonyI]-methylaminojethoxy] acetic acid A suspension is prepared of 8g (60 mM) of 2-(2-inethylaininoethoxy)acetic acid in 100 ml of chloroform and 20 ml of acetonitrile, and, at ambient temperature, 17 ml (120 mM) of triethylamine are added, then, dropwise, 7.63 ml (60 mM) of chlorotriinethylsilane. The mixture is agitated at 600C for 2 hours and then cooled to ambient temperature and 17 ml (120 mM) of triethylainine and then 16.48 g (60 mM) of 4-methoxy-2-(trifluoroinethyl)benzenesulphonyl chloride in solution in 60 ml of chloroform, are added slowly. The reaction mixture is kept under agitation at 50C for 16 hours, and then concentrated under reduced pressure. The residue is taken up into 150 ml of dichloroinethane and is treated with 40 ml of an N solution of hydrochloric acid. The organic phase is separated, washed with water, and then extracted with twice 120 ml of N sodium hydroxide. The basic aqueous phase is separated, washed with 100 ml of dichloroinethane and then acidified with a SN solution of hydrochloric acid. The precipitate formed is extracted with twice 80 ml of dichloroinethane; the organic phase obtained is washed with water and then dried over magnesium sulphate and concentrated under reduced pressure. The residue obtained is crystallised in isopropyl ether, separated off and dried. 6.32 g of the compound sought after are thus obtained as a white solid (yield = 280/a). M.Pt. = 600C PREPARATION XXVIII 4-(3-quinuclidinyl)piperazine- 1-carboxytic acid, 1,1-dimethylethyl ester 1 g (8 mM) of quinuclidinone, 1.63 g (8.75 mM) of 1-piperazinecarboxylic acid t-butyl ester (1-Boc-piperazine) and 2.71 ml (9.1 mM) of titanium isopropoxide are mixed and this mixture is kept under agitation for 1 hour. 5 ml of ethanol and then 460 mg (7.3 mM) of sodium cyanoborohydride are then added, and this mixture is agitated for 24 hours at ambient temperature. 25 ml of water are added and agitation is carried out for 15 minutes. The precipitate formed is separated off by filtration and the filtrate is concentrated under reduced pressure. The residue is purified by NH2 silica gel chromatography in eluting with the aid of a toluene/isopropanol mixture (95/5; v/v). 1 g of the compound sought after are thus obtained as a white solid (yield = 42 0bo). M.Pt. = 174 0C PREPARATION XXIX (3R5)-3-(1-piperazinyl)- 1-azabicyclo [2.2.2] octane or: (3(RS)-3-(1-piperazinyl)quinuclidine). A solution is prepared of 990 ing (3.35 mM) of the compound obtained according to preparation XXVIII in 10 ml of trifluoroacetic acid and the mixture is agitated for 30 minutes at 10 GC. 30 ml of toluene are then added and concentration is carried out under reduced pressure. The residue is taken up into 25 ml of methanol and the solution is agitated with 20 g of Ainberlite IRA 400 resin (OH) for 1 hour at ambient temperature. The resin is separated off by filtration, rinsed with 15 ml of methanol and the combined filtrates are concentrated under reduced pressure. 530 ing of the product sought after are thus obtained as a white paste (yield = 80 0h). 'H NMR (300 MHz, DMSO) 8: 2.79 (in, 1H) ; 2.67 (in, 7H); 2.50 (in, 2H) 2.22 (in, 4H) ; 1.91 (in, 1H) ; 1.85 (in, 1H) ; 1.58 (in, 2H) ; 1.32 (in, 1H) 1.22 (in, 1H). ExamDte 2 N-[2-[2-l14-[(3RS)- 1-azabicyclo[2. 2..2]oct-3-yI]-1-piperazinyl]-2- oxo-ethoxy]ethyl]-N,2,4,6-tetramethylbenzenesulphonamide, bis trifluoro-acetate 250 ing (0.32 mM) of TFP (tetrafluorophenol) grafted polystyrene resin are placed in 4 ml of DMF for 15 minutes, and 4 ing (0.03 mM) of 4-(diinethylainino)pyridine, 103 mg (0.32 mM) of acid obtained according to preparation V and 76 p.1 (0.48 mM) of diisopropylcarbodiiinide, are then added. The mixture is kept under agitation for 18 hours, and the resin is then separated off by filtration, rinsed twice with 3 ml of DMF and allowed to react with 44 ing (0.225 mM) of the amine obtained according to preparation XXIX, in 3 ml of DMF. The mixture is agitated for 1 hour at ambient temperature and the resin is separated off by filtration and rinsed with twice 3 ml of DMF. The filtrates are combined and treated with 20 mg of Ainberlite IRA 400 resin (OH-), and then with 20 ing of isocyanate grafted resin, and then concentrated under reduced pressure. The residue is purified by semi-preparative chromatography (conditions analogous to those of Example 1). 16 ing of the compound sought after are thus obtained as a white solid (yield = 8 0bo). M.Pt. = 78-80 0C Example 3 N-112-[2-[4-[(3RS)- 1-azabicyclo[2. 2. 2]oct-3-yt]-1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy- N, 2,6-trimethylbenzene-suiphonamide 500 ing (1.51 mM) of acid obtained according to preparation III, 319 mg (1.65 mM) of EDCI, 2.26 ing (1.65 ing) of HOAT and 233 p.1 of triethylainine are mixed in 10 ml of DMF and this reaction mixture is kept under agitation at ambient temperature for 30 minutes. 334 mg of the amine obtained according to preparation XXIX are then added and agitation is carried out for 20 hours at ambient temperature. The reaction mixture is poured onto iced water and extracted with DCM. The organic phase is dried over magnesium sulphate and concentrated under reduced pressure. The residue is purified by NH2 grafted silica gel chromatography in eluting with a toluene/isopropanol mixture (95/5 ; v/v). 140 mg of the product sought after are thus obtained as a colourless oil (yield = 18 %). 'H NMR (300 MHz, DMSO) 8: 6.80 (s, 2H) ; 4.05 (s, 2H) ; 3.80 (s, 3H) ; 3.53 (t, 2H) ; 3.41 (in, 2H) ; 3.31 (in, 2H) ; 3.22 (t, 2H) ; 2.85 (in, 1H) 2.70 (s, 3H); 2.57 (in, 5H) ; 2.53 (s, 6H) ; 2.27 (in, 4H) ; 1.90 (in, 2H) 1.60 (in, 2H); 1.35 (in, 1H); 1.20 (in, 1H). Example 4 N-[2-[2-[4-[(3RS)-1-azabicyclo[2.2.2]oct-3-yI]- 1- piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy- N, 2,6-trimethylbenzene-suiphonamide, difumarate A solution is prepared of 137 ing (0.269 mM) of the compound obtained according to Example 3 in 3 ml of methanol and 62.5 mg (0.538 mM) of fuinaric acid are added. The mixture is agitated for 30 minutes and then concentrated under reduced pressure. The residue is taken up into 5 ml of water and is freeze-dried. 200 ing of the salt sought after are thus obtained as a white powder (quantitative yield). M.Pt. = 86-90 0C Example 5 N-[2-[2-[4-lI(3S)- 1-azabicyclo[2.2.2]oct-3-yI]- 1-piperazinyl]-2- oxo-ethoxy]ethyl]-4-methoxy- N, 2,6-trimethylbenzene-suiphonamide 840 ing (2.53 mM) of acid obtained according to preparation III are mixed in 8 ml of anhydrous toluene and 0.1 ml of DMF. 0.245 ml (2.81 mM) of oxalyl chloride are added slowly. The reaction mixture is agitated for an hour at ambient temperature and is then concentrated under reduced pressure. The residue is taken up into 10 ml of toluene and is added dropwise to a solution of 0.5 g (2.56 mM) of 3(S)-(1-piperazinyl)quinuclidine and 0.39 ml (2.81 mM) of triethylamine in 10 ml of toluene. The reaction mixture is agitated for an hour at ambient temperature and 2 ml of ethanol and 10 g of silica gel for chromatography are then added. The solvents are removed under reduced pressure and the product which is adsorbed on the silica is purified by silica gel chromatography in eluting with the aid of an ethyl acetate/ethanol/aqueous ammonia mixture (6/3/1 ; v/v/v). The pure fractions are concentrated under reduced pressure, taken up into solution in ethyl acetate, dried over magnesium sulphate and concentrated. The product sought after is thus obtained as a colourless oil (yield = 71 %). 'H NMR (300 MHz, DMSO) 8: 6.80 (s, 2H) ; 4.06 (t, 2H) ; 3.80 (s, 3H) ; 3.53 (t, 2H) ; 3.41 (in, 2H) ; 3.31 (in, 2H) ; 3.22 (t, 2H) ; 2.85 (in, 1H) 2.69 (s, 3H) ; 2.57 (in, 5H) ; 2.53 (s, 6H) ; 2.27 (in, 4H) ; 1.90 (in, 2H) ; 1.60 (in, 2H); 1.35 (in, 1H) ; 1.20 (in, 1H). Exam~Ie 6 N-[2-[2-[4-[(3S)- 1-azabicyclo[2.2.2]oct-3-yI]- 1- piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy- N,2,6-trimethyl benzenesuiphonamide, fumarate 0.84 g (1.65 mM) of the compound obtained according to Example 5 are dissolved in 50 ml of methanol and 0.192 g (1.64 mM) of fuinaric acid are added. The mixture is agitated until complete dissolution and is concentrated under reduced pressure. The residue is taken up into solution in 40 ml of water, the solution is filtered and freeze-dried. 1 g of the salt sought after are thus obtained as a white powder (yield = 97%). M.Pt. = 86 0C [~]25D = -6.5 G (C = 0.31 ; CH3OH) Examole 7 N-[2-[2-[4-[(3R)- 1-azabicyclo[2.2.2]oct-3-yI]-1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy- N,2,6-trimethylbenzene-suiphonamide, fumarate The raceinic mixture obtained according to Example 3 is separated by chromatography on chiral phase (Chiralpack AD column) in eluting with a hexane/ethanol/isopropanol/trifluoroacetic acid mixture (60/25/15/0.05). Starting with 500 ing of the raceinic mixture, 260 ing of enantioiner S and 100 ing of enantioiner R are obtained. Each enantiomer is placed in solution in methanol and treated with 1 g of Ainberlite IRA 400 resin (0H). The treated solution is filtered and concentrated under reduced pressure and the basic compounds obtained are salified with fumaric acid, analogously to the operation described for Example 6. 143 mg of enantioiner S and 68 mg of enantioiner R are thus obtained. M.Pt. = 84 0C = 7.2 0 (C = 0.31 ; CH3OH) PREPARATION XXX 4-(8-methyt-8-azabicyclo[3 .2. 1]oct-3-yI)- 1-piperazine-carboxylic acid, 1,1-dimethylethyl ester In operating analogously to preparation XXVIII, starting with 8-inethyl-8-azabicyclo[3.2.1]octan-3-one (tropinone), the ester sought after is obtained as a white solid (yield = 53 Obo) 'H NMR (300 MHz, DMSO) 8: 3.25 (in, 4H) ; 3.15 (in, 2H) ; 2.51 (in, 2H) 2.35 (in, 4H) ; 2.20 Cs, 3H); 1.92 (in, 3H); 1.53 (in, 4H) ; 1.38 (s, 9H). PREPARATION XXXI 8-methyl-3-( 1-piperazinyl)-8-azabicyclo[3.2. 1]octane In operating analogously to preparation XXIX, starting with the compound obtained according to preparation XXX, the product sought after is obtained as a yellow oil (yield = 99 0/c,). 'H NMR (300 MHz, DMSO) 8: 3.70 (in, 2H) ; 3.03 (in, 4H) ; 2.75 (in, 1H) ; 2.61 (in, 4H) ; 2.53 Cs, 3H) ; 2.10 (in, 2H); 1.75 (in, 6H). PREPARATION XXXII 4-(1-azabicyclo[2.2.2]oct-3-yI)hexahydro- 1H- 1,4-diazepine-1-carboxylic acid, 1, 1-dimethylethyl ester In operating analogously to preparation XXVIII, starting with 1-hoinopiperazinecarboxylic acid t-butyl ester, the product sought after is obtained as a colourless paste (yield = 67 0/a). 'H NMR (300 MHz, DMSO) 8: 3.34 (in, 4H) ; 2.81-2.35 (in, 11H) ; 1.88 (in, 1H) ; 1.65 (in, 4H); 1.39 Cs, 9H) ; 1.34 (in, 1H) ; 1.18 (in,1H). PREPARATION XXXIII 3-(hexahydro-1H-1,4-diazepine-1-yI)-1-azabicyclo[2.2.2]octane In operating analogously to preparation XXIX, starting with the compound obtained according to preparation XXXII, the product sought after is obtained as a yellow oil (yield = 98 Gbo). 'H NMR (250 MHz, DMSO) 6: 3.41 (in, 1H) ; 3.11 (in, 8H) ; 2.96 (in, 1H) 2.78 (in, 4H); 2.52 (in, 1H); 2.24 (in, 1H) ; 1.89 (in, 4H); 1.85 (in, 1H) 1.62 (in, 1H). In operating analogously to Example 1, starting with kown piperazine derivatives described in the literature or described above, the following Examples are prepared: Example 8 1- [[2-[[(4-methoxy-2,6-dimethyl phenyl)sulphonyl]methylamino]ethoxy]-acetyl ]-4-[3-(1-pyrrolidinyl)propyl]piperazine, bis-trifluoroacetate Yield = 90 ~bo (colourless paste). 'H NMR (300 MHz, CD3CN) 8: 6.74 (5, 2H) ; 4.12 (s, 2H) ; 3.81 (s, 3H); 3.78 (in, 4H) ; 3.62 Ct, 2H) ; 3.34 Ct, 2H) ; 3.27 (in, 12H) ; 2.73 (s, 3H) 2.57 (s, 6H) ; 2.22 (in, 2H); 2.03 (in,4H). Example 9 1-[[2-[[(4-methoxy-2,6-dimethylphenyl)sulphonyl]methyl-amino]-ethoxy]-acetyl]-4-[2-(4-morpholinyt)ethyl]piperazine, bis-trifi uoroacetate Yield = 51 0/a (colourless paste) 'H NMR (300 MHz, CD3CN) 6: 6.75 (5, 2H) ; 4.11 Cs, 2H); 3.92 (in, 4H); 3.81 (s, 3H) ; 3.76 (in, 4H) ; 3.61 Ct, 2H) ; 3.48 (in, 4H) ; 3.35 (t, 2H) 3.27 (in, 8H); 2.72 (s, 3H); 2.57 (s, 6H). Example 10 1- [[2-[[(4-methoxy-2,6-dimethyl phenyl)sulphonyl]methylamino]ethoxy]acetyl]-4-[2-( 1-piperidinyl)ethyl]piperazine, bis-trifluoroacetate Yield = 92 Gbo (colourless paste) 'H NMR (300 MHz, CD3CN) 6: 6.74 (s, 2H) ; 4.10 (s, 2H) ; 3.81 (s, 3H) 3.81 (in, 4H); 3.61 (t, 2H); 3.40 (in, 2H); 3.34 (in, 4H); 3.24 (in, 4H) 3.09 (in, 4H); 2.74 (s, 3H); 2.57 (s, 6H); 1.90 (in, 4H); 1.64 Cm, 2H). Example 11 1-[[2-flX4-methoxy-2,6-dimethylphenyl)sulphonyl]methyl-amino]ethoxy]acetyl]-4- [3-(1-piperidinyl)propyl]piperazine, bis-trifi uoroacetate Yield = 85 0/~ (colourless paste). 'H NMR (300 MHz, CD3CN) 8: 6.74 (s, 2H) ; 4.10 (s, 2H) ; 3.96 (s, 3H); 3.80 (in, 2H) ; 3.60 (t, 2H) ; 3.50 (in, 4H) ; 3.30 (t, 2H) ; 3.15 (in, 2H) 3.10 (in, 4H); 2.80 (in, 4H); 2.75 (s; 3H); 2.55 (s, 6H); 2.20 (in, 2H) 1.93 (in, 5H); 1.37 (in, 1H). Example 12 1-[[2-[[(4-methoxy-2,6-dimethylphenyl)sulphonyl ]methylamino]-ethoxy]-acetyl]-4-[3-(dimethylamino)propyl] piperazine, bis-trifi uoroacetate Yield = 74 % (colourless paste) 'H NMR (300 MHz, CD3CN) 8 : 6.74 (s, 2H) ; 4.11 (s, 2H) ; 3.81 (s, 3H) 3.78 (in, 4H) ; 3.63 (t, 2H) ; 3.31 (t, 2H) ; 3.22 (in, 4H); 3.15 (in, 4H) 2.81 (s, 6H); 2.74 (s, 3H); 2.57 (s, 6H); 2.23 (in, 2H). In operating analogously to Examples 3 and 4, starting with derivatives of piperazine or of hoinopiperazine described above, the following Examples are prepared Example 13 4-methoxy-N,2,6-trimethyl-N- [2- [2- [4-(l-methyl-4-piperidinyl)- 1-piperazinyl]-2-oxoethoxy]ethyl]benzenesu Iphonamide, bis trifluoroacetate Yield = 74 0/a (colourless paste) 'H NMR (300 MHz, CD3CN) 8 : 6.74 (s, 2H) ; 4.11 (s, 2H) ; 3.81 (s, 3H) 3.80 (in, 4H); 3.77 (d, 2H) ; 3.64 (in, 2H); 3.55 (in, 1H) ; 3.34 (t, 2H); 3.26 (in, 4H) ; 3.01 (in, 2H) ; 2.79 Cs, 3H) ; 2.74 (s, 3H) ; 2.57 (s, 6H) 2.29 (in, 4H). Example 14 4-methoxy-N,2,6-trimethyl-N-[2-[2-[4-(8-methyl-8-azabicyclo[3.2. 1]-oct-3-yI)-1-piperazinyl]-2-oxoethoxy]ethyl]-benzenesulphonamide, fumarate Yield = 62 0/0 (white solid) M.Pt. = 88-90 0C Example 15 1-( 1-azabicyclo[2.2.2]oct-3-yI)hexahydro-4-[[2-[[(4-methoxy- 2,6-dimethylphenyl)sulphonyl]methylamino]ethoxy]acetyl]- iN1,4-diazepine, fumarate Yield = 47 0/0 (white solid) M.Pt. = 90 0C PREPARATION XXXIV 4-[ 1-( 1, 1-dimethylethyl)-4-piperidinyl]- 1-piperazinecarboxylic acid, phenylmethyl ester In operating analogously to preparation XXVIII, starting with 1-(1,1- diinethylethyl)-4-piperidinone and the benzyl ester of 1- piperazinecarboxylic acid, the product sought after is obtained as a white solid (yield = 560bo). M.Pt. = 70-72 0C PREPARATION XXXV 1-[ 1-( 1,1-dimethylethyl)-4-piperidinyl] piperazine A solution is prepared of 570 mg (1.59 mM) of the compound obtained according to preparation XXXIV in 20 ml of methanol and 114 ing of 100/0 palladium on carbon are added. The mixture is agitated under an atmosphere of hydrogen for 2 hours at ambient temperature and at atmospheric pressure. The catalyst is removed by filtration and the filtrate is concentrated under reduced pressure. The crude product is purified by silica gel chromatography in eluting with the aid of a dichloroinethane/methanol/aqueous ammonia mixture (90/10/1 ; v/v/v). 270 ing of the compound sought after are thus obtained as a white powder (yield = 750bo). M.Pt. = 1060C PREPARATION XXXVI 4-(9-methyl-9-azabicycio[3.3.1]non-3-yI)-1-piperazinecarboxylic acid, phenylmethyl ester In operating analogously to preparation XXVIII, starting with 9-inethyl-9-azabicyclo[3.3.1]nonan-3-one and the benzyl ester of 1-piperazinecarboxylic acid, the product sought after is obtained as a pale yellow solid (yield = l8Obo). M.Pt. = 74 0C PREPARATION XXXVII 1-(9-methyl-9-azabicyclo[3.3. lJnon-3-yI)piperazine In operating analogously to preparation XXXV, starting with the compound obtained according to preparation )O0(VI, the product sought after is obtained as a yellow oil (yield = lOOObo). 'H NMR (300 MHz, D20) 8: 3.74 (in, 2H); 3.59 (in, 1H); 3.43 (in, 4H); 3.15 Cm, 4H) ; 3.01 and 2.97 (2s, 3H) ; 2.46 (dd, 1H) ; 2.30 (in, 2H) 2.10 (in, 4H); 1.83 (in, 3H). PREPARATION XXXVIII 4-(1,2,2,6,6-pentamethyl-4-piperidinyl)- 1-piperazinecarboxylic acid, phenylmethyl ester In operating analogously to preparation XXVIII, starting with. 1,2,2,6,6-pentainethyl-4-pi peridinone and the benzyl ester of 1-pi perazi necarboxyl ic acid, the product sought after is obtained as a colourless oil (yield = 520bo). 'H NMR (300 MHz, DMSO) 8: 7.36 Cm, 5H); 5.07 (s, 2H); 3.37 Cm, 4H); 2.85 (in, 1H); 2.50 (in, 7H) ; 1.80 (in, 2H); 1.48 (in, 2H); 1.28 Cs, 6H); 1.21 (s, 6H). PREPARATION XXXIX 1-(1,2,2,6,6-pentamethyl-4-piperidinyl)piperazine In operating analogously to preparation XXXV, starting with the compound obtained according to preparation XXXVIII, the product sought after is obtained as a white solid (yield = 350/o). M.Pt. = 650C PREPARATION XL 4-[ 1-( 1-methylethyl)-4-piperidinyl]- 1-piperazinecarboxylic acid, 1, 1-dimethylethyl ester In operating analogously to preparation XXVIII, starting with 1-Cl-methylethyl)-4-piperidinone, the product sought after is obtained as a yellow solid (yield = 31%). M.Pt. = 53 0C PREPARATION XLI 1-[1-( 1-methylethyl)-4-piperidinyl]piperazine, trihydrochioride A solution is prepared of 247 mg (0.79 mM) of the compound obtained according to preparation XL in 1 ml of methanol, and 15 ml of a 2.3 N solution of hydrogen chloride in ethyl acetate are added. The mixture is agitated for 4 hours at ambient temperature. The reaction mixture is concentrated under reduced pressure. 239 ing of the compound sought after are thus obtained as a white powder.(yield = 750h). M.Pt. = 262GC PREPARATION XLII 4-C 1-cyclopropyl-4-piperidrnyl)-1-piperazinecarboxylic acid, phenylmethyl ester In operating analogously to preparation XXXIV, starting with 1-cyclopropyl-4-piperidinone, the product sought after is obtained as a white solid (yield = 67%). M.Pt. = 88 0C PREPARATION XLIII 1-(1-cyclopropyl-4-piperidinyl)piperazi ne In operating analogously to preparation XXXV, starting with the compound obtained according to preparation XLII, the product sought after is obtained as a white solid (yield = 92%). M.Pt. = 580C PREPARATION XLIV 4-(1-methyl-4-piperidinyl)hexahydro- XH-1,4-diazepine- 1-carboxylic acid, 1,1-dimethylethyl ester In operating analogously to preparation XXXII, starting with 1-methyl-4-piperidinone, the product sought after is obtained as a yellow oil (yield = 78%). 'H NMR (250 MHz, CDCI3) 8: 3.43 (in, 4H); 3.10 (din, 2H) ; 2.70 (in, 4H) 2.61 (in, 1H); 2.44 (s, 3H) ; 2.28 (in, 2H) ; 1.86 (in, 6H); 1.45 Cs, 9H). PREPARATION XLV 1-( 1-methyl-4-piperidinyl)hexahydro- 1H- 1,4-diazepine, trihydrochioride In operating analogously to preparation XLI, starting with the compound obtained according to preparation XLIV, the product sought after is obtained as a beige solid (yield = 990bo). M.Pt. = 186GC PREPARATION XLVI 4-(8-cyclopropyl-8-azabicyclo[3.2. 1]oct-3-yI)-1-piperazinecarboxylic acid, 1, 1-dimethylethyl ester In operating analogously to preparation XXVIII, starting with 8- cyclopropyl-8-azabicycloll3 .2. 1]octan-3-one, the ester sought after is obtained as a white paste (yield = 45 0/a). 'H NMR (300 MHz, DMSO) 8: 3.24 (in, 6H) ; 2.50 Cm, 5H); 2.34 (t, 4 H); 1.87 (in, 3H); 1.48 (dd, 6H); 1.38 Cs, 9H); 0.36 (in, 2H); 0.25 (in, 2H). PREPARATION XLVII 8-cyclopropyl-3-(1-piperazinyl)-8-azabicyclo[3.2. ijoctane In operating analogously to preparation XXIX, starting with the compound obtained according to preparation XLVI, the product sought after is obtained as a white solid (yield = 95 0/o). 'H NMR (250 MHz, CDCI3) 8: 3.37 Cm, 2H); 2.94 (t, 2H) ; 2.58 (in, 4H); 2.51 Cm, 1H); 1.96 Cm, 3H); 1.74 Ct, 2H); 1.54 Cm, 4H) ; 0.43 Cd, 4H). PREPARATION XLVIII 4- [ 1-[(1, 1-dimethylethoxy)carbonylJ-4-piperidinyl]- 1-piperazinecarboxylic acid, phenylmethyl ester In operating analogously to preparation )O(XIV, starting with the t-butyl ester of 4-oxo-1-piperidinecarboxylic acid, the product sought after is obtained as a yellow oil (yield = 30%). 'H NMR (250 MHz, DM50) 8: 7.35 (in, 5H) ; 5.06 Cs, 2H) ; 3.93 (d, 2H); 3.36 (in, 4H) ; 2.68 Ct, 2H) ; 2.44 Ct, 4H) ; 2.37 Cm, 1H) ; 1.66 Cm, 2H) 1.38 (s, 9H); 1.26 Cm, 2H). PREPARATION IL 4-(4-piperidinyl)- 1-piperazinecarboxylic acid, phenylmethyl ester In operating analogously to preparation XXIX, starting with the compound obtained according to preparation XLVIII, the product sought after is obtained as a yellow oil (yield = 100%). 'H NMR (250 MHz, DMSO) 8 : 8.91 (in broad, h) ; 8.63 (in broad, 1H) 7.36 (in, 5H); 5.11 Cs, 2H); 3.80 Cm, 2H); 3.45 Cm, 4H) ; 3.22 Cm, 5H); 2.92 (q, 2H) ; 2.20 Cd, 2H); 1.82 (dq, 2H). PREPARATION L 4-(1-ethyl-4-piperidinyl)- 1-piperazinecarboxylic acid, phenylmethyl ester In operating analogously to preparation XXXIV, starting with acetaldehyde and the compound obtained according to preparation IL, the product sought after is obtained as a colourless oil (yield = 720bo). 'H NMR (250 MHz, DMSO) 8: 7.34 Cm, SH); 5.07 Cs, 2H) ; 3.90 (in, 7H); 3.02 (q, 2H) ; 2.84 Cm, 2H) ; 2.45 Ct, 4H) ; 1.91 Cm, 2H) ; 1.63 Cm, 2H) 1.19 (t, 3H). PREPARATION LI 1-(1-ethyl-4-piperidinyl)piperazine In operating analogously to preparation XXXV, starting with the compound obtained according to preparation L, the product sought after is obtained as a yellow oil (yield = 71%). 'H NMR (250 MHz, DMSO) 8: 2.90 (in, 6H); 2.52 (in, 4H); 2.30 (q, 2H); 2.17 (tt, 1H); 1.85 Cdt, 2H); 1.69 (in, 2H); 1.38 (dq, 2H) ; 0.97 Ct, 3H). PREPARATION LII 4-[8-[(1, 1-dimethylethoxy)carbonyl]-8-azabicyclo[3.2. 1]oct-3-yI]-1-p;perazinecarboxylic acid, phenylmethyl ester In operating analogously to preparation XXVIII, starting with the t-butyl ester of 3-oxo-8-azabicyclo[3 .2.1 ]octa ne-8-carboxyl ic acid, the ester sought after is obtained as a white solid (yield = 40 Obo). 'H NMR (250 MHz, CD3CN) 8: 7.33 (in, 5H) ; 5.07 Cs, 2H) ; 4.13 (in, 2H); 3.37 Ct, 4H); 2.80 (hep, 1H); 2.43 Ct, 4H); 1.87 Cm, 2H); 1.62 (in, 6H); 1.42 Cs, 9H). PREPARATION LIII 4-(8-azabicyclo[3.2. 1]oct-3-yI)- 1-piperazineca rboxylic acid, phenylmethyl ester, hydrochloride In operating analogously to preparation XLI, starting with the compound obtained according to preparation LII, the product sought after is obtained as a colourless oil (yield = 96 0bo). 'H NMR (250 MHz, DMSO) 6:11.78 (m broad, 1H) ; 9.45 Cs, 2H) ; 7.38 (in, SH) ; 5.11 Cs, 3H) ; 4.09 (in, 4H) ; 3.95 Cm, 1H) ; 3.43 Cm, 4H); 3.07 (in, 2H) ; 2.22 Cm, 4H); 1.92 (in, 4H). PREPARATION LIV 4-(8-ethyl-8-azabicyclo(3.2. 1]oct-3-yl)-1-piperazinecarboxylic acid, phenylmethyl ester In operating analogously to preparation XXXIV, starting with acetaldehyde and the compound obtained according to preparation LIII, the product sought after is obtained as a colourless oil (yield = 99 0A,). 'H NMR (250 MHz, CD3CN) 6: 7.33 (in, 5H) ; 5.07 Cs, 2H) ; 3.39 Cm, 6H) ; 2.63 (in, 1H); 2.56 (q, 2H); 2.42 Ct, 4H); 1.93 (in, 2H); 1.61 Cm, 6H); 1.06 (t, 3H). PREPARATION LV 1-(8-ethyl-8-azabicyclo[3.2. 1]oct-3-yl)piperazine In operating analogously to preparation XXXV, starting with the compound obtained according to preparation LIV, the product sought after is obtained as a colourless oil (yield = 78 Gbo). 'H NMR (300 MHz, CDCI3) 8: 3.57 (in, 2H) ; 2.94 Ct, 2H) ; 2.71 (q, 2H); 2.59 Cm, 4H); 2.52 Cm, 1H); 1.99 Cm, 4H); 1.64 Cm, 4H). PREPARATION LVI 4-[8-(1-methylethyl)-8-azabicyclo[3.2. 1]oct-3-yI]- 1- piperazineca rboxyl ic acid, phenylmethyl ester In operating analogously to preparation XXXIV, starting with acetone and the compound obtained according to preparation LIII, the product sought after is obtained as a colourless oil (yield = 77 %). 'H NMR (250 MHz, CDCI3) 8: 7.32 (in, 5H) ; 5.12 Cs, 2H); 3.64 (in, 2H) 3.49 Ct, 4H) ; 2.92 (quin, 1H) ; 2.59 (hep, 1H) ; 2.47 Cm, 4H) ; 1.99 (in, 2H); 1.82 Cdt, 2H); 1.63 Cm, 2H); 1.48 (in, 2H); 1.14 Cd, 6H). PREPARATION LVII 1-[8-(1-methylethyl)-8-azabicyclo[3.2. 1]oct-3-yI] piperazine In operating analogously to preparation XXXV, starting with the compound obtained according to preparation LVI, the product sought after is obtained as a colourless oil (yield = 82 0bo). 'H NMR (250 MHz, CDCI3) 6: 3.79 (in, 2H) ; 3.05 (quin, 1H) ; 2.98 Cm, 4H) ; 2.71 (hep, 1H) ; 2.61 Cm, 4H) ; 2.13 (in, 2H) ; 1.95(m, 2H) ; 1.65 (in, 4H); 1.29 Cd, 6H). PREPARATION LVIII Hexahydro-1-methyl-4-(1-oxo-2-propenyl)- 1H- 1,4-diazepine A solution is prepared of 20 g (175 mM) of N-methylhomopiperazine in 100 ml of dichloromethane, to which is added, dropwise, at 0 0C, a solution of 15.85 g (175 mM) of acryloyl chloride in 20 ml of dichloromethane. The reaction mixture is agitated for 1 hour at 00C, and then for 2 hours at ambient temperature, and then hydrolysed with a solution of 12 g of sodium carbonate in 20 ml of water. The mixture is decanted, the organic phase is washed once with water and then dried over magnesium sulphate and concentrated under reduced pressure. 23 g of the compound sought after are thus obtained, as an orangy oil, which is used, without other purification, in the next step. PREPARATION LIX 4- [3-(hexahydro-4-methyl- 1H-1,4-diazepin- 1-yI)-3-oxopropyl]- 1-pi perazineca rboxylic acid, phenylmethyl ester A solution is prepared of 7g (41 mM) of the compound obtained according to preparation LVIII in 100 ml of toluene, to which 11 g (50 mM) of the benzyl ester of 1-piperazinecarboxylic acid are added. The reaction mixture is agitated for 16 hours under reflux of the solvent, and then concentrated under reduced pressure. The residue is taken up into ethyl acetate and the organic phase is washed once with water and then dried over magnesium sulphate and concentrated under reduced pressure. The crude product is purified by silica gel chromatography in eluting with the aid of a toluene/isopropanol/aqueous ammonia mixture (80/20/1 ; v/v/v). 4.1 g of the compound sought after are thus obtained as a yellow oil (yield = 26 0/a) 'H NMR (250 MHz, DMSO) 8: 7.36 (in, SH); 5.06 Cs, 2H) ; 3.47 (in, 4H); 3.37 Cm, 4H); 2.50 Cm, 8H) ; 2.35 Cm, 4H); 2.24 and 2.21 (2s, 3H); 1.75 (in, 2H). PREPARATION LX 1-[3-(hexahydro-4-methyl- 1H- 1,4-d iazepin- 1-yI)-3-oxopropyl]piperazine In operating analogously to preparation XXXV, starting with the compound obtained according to preparation LIX, the product sought after is obtained as a colourless oil (yield = 65 0b~). 'H NMR (250 MHz, DMSO) 8: 3.48 (in, 4H) ; 2.67 Ct, 4H) ; 2.48 Cm, 8H) 2.30 Ct, 4H) ; 2.25 and 2.22 (2s, 3H); 1.73 (in, 2H). PREPARATION LXI 1- [3-(hexahydro-4-methyl- 1H- 1,4-diazepin- 1-yI)propyl]piperazine A suspension is prepared of 120 ing (3.1 mM) of lithium aluminium hydride in 3 ml of tetrahydrofuran (THF) and a solution of 800 mg (3.1 mM) of the compound obtained according to preparation LX in 10 ml of THF is added. The reaction mixture is heated under gentle reflux of the solvent for 4 hours, and then cooled to ambient temperature. 200 ing of Glauber's salt are added to the reaction mixture and then, after around 15 minutes, 50 ml of ethyl acetate are added. The suspension obtained is filtered and the filtrate is concentrated under reduced pressure. The crude product is purified by silica gel chromatography in eluting with the aid of a dichloromethane/methanol/aqueous ammonia mixture (80/20/10; v/v/v). The product sought after is thus obtained as a colourless oil (yield = 34 'H NMR (250 MHz, DMSO) 8: 2.64 Ct, 4H); 2.57 (in, 4H) ; 2.49 (in, 4H); 2.38 Ct, 2H) ; 2.23 Cm, 6H) ; 2.21 Cs, 3H) ; 1.66 (quin, 2H) ; 1.52 (quin, 2H). PREPARATION LXII 4-[2-(hexahydro-4-methyl- 1H- 1,4-diazepin- 1-yI)-2-oxoethyl]-1-piperazinecarboxyl Ic acid, phenylmethyl ester A solution is prepared of 10 g (87.5 mM) of N-methylhomopiperazine in 200 ml of dichloromethane, to which 36.6 ml of triethylamine are added. The mixture is cooled to —780C and 6.97 ml of chloroacetyl chloride are added dropwise. The reaction mixture is agitated for 1.5 hours at —780C, and a solution of 19.3 g (87.6 mM) of the benzyl ester of 1-piperazinecarboxylic acid in 10 ml of dichloromethane is then added. The mixture is then left to come back to ambient temperature, and agitation is carried out for 15 hours. The medium is then hydrolysed with a solution of sodium carbonate. The mixture is decanted, the organic phase is washed once with water and then dried over magnesium sulphate and concentrated under reduced pressure. The crude product is purified by silica gel chromatography in eluting with the aid of a dichloromethane/methanol/aqueous ammonia mixture (90/10/5; v/v/v). The product sought after is thus obtained as a yellow oil (yield = 43 O/~). 'H NMR (250 MHz, DMSO) 8: 7.36 (in, SH); 5.07 Cs, 2H) ; 3.55 (in, 2H); 3.44 (in, 2H); 3.38 (in, 4H); 3.16 Cd, 2H); 2.60 Cm, 2H); 2.44 (in, 6H) 2.24 and 2.22 (2s, 3H); 1.76 Cm, 2H). PREPARATION LXIII 1-[2-(hexahydro-4-methyl- 1H- 1,4-diazepin-1-yI)-2-oxoethyl ]piperazine In operating analogously to preparation XXXV, starting with the compound obtained according to preparation LXII, the product sought after is obtained as a colourless oil (yield = 60 0b~). 'H NMR (250 MHz, DMSO) 8: 3.56 Cm, 2H); 3.44 Cm, 2H); 3.10 Cd, 2H); 2.74 (dd, 4H) ; 2.61 (in, 1H2.44 Cm, 4H) ; 2.39 (in, 3H) ; 2.25 and 2.22 C2s, 3H); 1.78 Cm, 2H). PREPARATION LXIV 1-[2-(hexahydro-4-methyl- 1H-1,4-diazepin-1-yI)ethyl]piperazine In operating analogously to preparation LXI, starting with the compound obtained according to preparation LXIII, the product sought after is obtained as a yellow oil Cyield = 21 Obo). 'H NMR (300 MHz, DMSO) 8: 2.63 (in, 8H) ; 2.49 Cm, SH); 2.28 Cm, 7H) 2.21 Cs, 3H); 1.66 (quin, 2H). PREPARATION LXV 1-( 1-oxo-2-propenyl)azetidine In operating analogously to preparation LVIII, starting with azetidine, the product sought after is obtained as a yellow oil which is allowed to react in the following preparation without purification. PREPARATION LXVI 4-[3-(1-azetidinyl)-3-oxopropyl]- 1-piperazinecarboxylic acid, phenylmethyl ester In operating analogously to preparation LIX, starting with the compound obtained according to preparation LXV, the product sought after is obtained as a yellow oil (yield = 14 0bo). 'H NMR (250 MHz, DMSO) 8: 7.34 (in, SH); 5.06 (s, 2H); 4.09 Ct, 2H); 3.80 Ct, 2H) ; 3.35 (in, 4H); 2.48 Ct, 2H) ; 2.33 Ct, 4H) ; 2.16 (in, 4H). PREPARATION LXVII 1-[3-(1-azetidinyl)-3-oxopropyl]piperazine In operating analogously to preparation XXXV, starting with the compound obtained according to preparation L)(VI, the product sought after is obtained as a yellow solid Cyield = 100 0bo). M.Pt. = SOGC PREPARATION LXVIII 1-[3-( 1-azetidinyl)propyl]piperazine In operating analogously to preparation LXI, starting with the compound obtained according to preparation L)(VII, the product sought after is obtained as a yellow oil (yield = 30 0/a). 'H NMR (300 MHz, DMSO) 8: 3.19 (in broad, 1H) ; 3.02 Ct, 4H); 2.66 (t, 4H); 2.25 (in, 8H); 1.93 (quin, 2H); 1.36 (quin, 2H). PREPARATION LXIX a-[(dimethylamino)methyl]-4-piperidinemethanol 20 g (83.6 mM) of 2-II(dimethylamino)methyl]-4-pyridinemethanol dihydrochloride are dissolved in 200 ml of methanol at 50 0C. 2 g of platinum oxide are then added under an atmosphere of nitrogen, and the mixture is agitated under an atmosphere of hydrogen, at 50 0C, under a pressure of 300 hPa C3 bars), for 7 hours. This catalyst is then removed by filtration and the filtrate is concentrated under reduced pressure. The solid residue is taken up with 10 ml of iON sodium hydroxide and 150 ml of chloroform. The organic phase is separated and washed with a solution of sodium chloride, dried over magnesium sulphate and concentrated under reduced pressure. The product sought after is thus obtained as an oil which crystallises (yield = 87 0/a). M.Pt. = 98GC PREPARATION LXX 4-(1-pyrrolidinylmethyl)piperidine In operating analogously to preparation LXIX, starting with 4-(1-pyrrolidinylmethyl)pyridine, the product sought after is obtained as a yellow oil. PREPARATION LXXI 4-[(4-(1-methylethyl)-1-piperazinyl]- 1-piperidinecarboxylic acid, phenylmethyl ester A mixture is prepared of 827 mg (3.54 mM) of the benzyl ester of 4-oxo-1-piperidinecarboxylic acid, 500 mg (3.9 mM) of N-isopropylpiperazine and 1.2 g (4.25 mM) of titanium isopropoxide in 10 ml of methanol. 148 mg of sodium borohydride are added under agitation and at ambient temperature. The reaction mixture is kept under agitation for 16 hours, and then diluted with 20 ml of water. The suspension obtained is filtered and the precipitate is washed with 30 ml of ethyl acetate which is then used to extract the filtrate. The organic phase obtained is washed with water and then dried over magnesium sulphate and concentrated under reduced pressure. The yellow oil obtained is purified by silica gel chromatography in eluting with the aid of a dichloromethane/methanol mixture (9/1 ; v/v). 235 mg of the product sought after are thus obtained as a white solid (yield = l90/a). M.Pt. = 550C PREPARATION LXXII 4-[4-(1-methylethyl)- 1-piperazinyl]piperidine In operating analogously to preparation XXXV, starting with the ester obtained following preparation LXXI, the product sought after is obtained as a white solid (yield = 980bo). M.Pt. = 65GC PREPARATION LXXIII 4-[(4-methyl- 1-piperazinyl)methyl]- 1-piperidinecarboxylic acid, phenylmethyl ester In operating analogously to preparation LXXI, starting with Nmethylpiperazine and the benzyl ester of 4-formyl-1-piperidinecarboxylic acid, the product sought after is obtained as a colourless oil (yield = 52%) 'H NMR (250 MHz, DMSO) 8 : 7.34 Cm, 5H) ; 5.05 Cs, 2H) ; 3.98 (in, 2H) ; 2.77 Cm, 2H); 2.29 (in, 8H) ; 2.19 Cs, 3H); 2.08 (d, 2H) ; 1.67 Cm, 3H) 0.95 (in, 2H). PREPARATION LXXIV 4-[(4-methyl-1-piperazinyl)methyl]piperidine In operating analogously to preparation XXXV, starting with the ester obtained following preparation LXXIII, the product sought after is obtained as a colourless oil (yield = 77~b~). 'H NMR (250 MHz, DMSO) 6: 2.89 (in, 2H) ; 2.51 (in, 2H); 2.28 Cm, 8H) 2.12 Cs, 3H); 2.05 Cd, 2H) ; 1.55 Cm, 3H); 1.02 (in, 2H). PREPARATION LXXV 4-[(1-azetidinyl)methyl]-1-piperidinecarboxylic acid, phenylmethyl ester In operating analogously to preparation LXXIII, starting with azetidine, the product sought after is obtained as a colourless oil (yield = 69%). 'H NMR (300 MHz, DMSO) 8: 7.34 Cm, 5H); 5.04 Cs, 2H); 3.95 Cm, 2H); 3.06 (t, 4H); 2.75 (in, 2H); 2.18 Cd, 2H); 1.94 (quin, 2H); 1.61 (in, 2H) 1.38 Cm, 1H) ; 0.94 (in, 2H). PREPARATION LXXVI 4-[(1-azetidinyl)methyl]piperidine In operating analogously to preparation XXXV, starting with the ester obtained following preparation LXXV, the product sought after is obtained as a colourless oil (yield = 930bo). 'H NMR C250 MHz, DMSO) 8: 3.06 (t, 4H); 2.92 Cm, 2H); 2.50 Cm, 2H); 2.15 Cd, 2H) ; 1.91 (quin, 2H) ; 1.59 Cm, 2H) ; 1.30 (in, 1H) ; 1.00 (in, 2H). PREPARATION LXXVII 4-[(dimethylamino)methyl]- 1-piperidinecarboxylic acid, phenylmethyl ester In operating analogously to preparation LXXIII, starting with diinethylamine, the product sought after is obtained as a colourless oil (yield = 780h). 'H NMR (300 MHz, DMSO) 8: 7.35 (in, 5H) ; 5.05 (5, 2H); 3.97 (in, 2H) 2.79 (in, 2H); 2.09 Cs, 6H) ; 2.02 Cd, 2H); 1.68 Cd, 2H); 1.61 (in, 1H) 0.96 Cm, 2H). PREPARATION LXXVIII 4-[(dimethylami no)methyl]piperidine In operating analogously to preparation )OO(V, starting with the ester obtained following preparation LXXVII, the product sought after is obtained as a colourless oil (yield = 900/a). 'H NMR (300 MHz, DMSO) 8 : 2.91 Cm, 2H); 2.43 (in, 2H); 2.08 Cs, 6H); 2.01 Cd, 2H); 1.59 (in, 2H); 1.49 Cm, 1H); 0.96 (dq, 2H). PREPARATION LXXIX 4-[(4-ethyl- 1-piperazinyl)methyl]- 1-piperidinecarboxylic acid, 1,1-dimethylethyl ester In operating analogously to preparation LXXIII, starting with Nethylpiperazine and the t-butyl ester of 4-formyl-1-piperidinecarboxylic acid, the product sought after is obtained as a colourless oil (yield = 780bo). 'H NMR (300 MHz, DMSO) 8: 3.90 (in, 2H); 2.67 Cm, 2H) ; 2.29 Cm, 1OH) 2.09 Cd, 2H); 1.63 Cm, 3H); 1.38 Cs, 9H); 0.96 Ct, 3H); 0.85 Cm, 2H). PREPARATION LXXX 4-[(4-ethyl- 1-piperazinyl)methyl]piperidine In operating analogously to preparation XXIX, starting with the ester obtained following preparation LXXIX, the product sought after is obtained as a colourless oil (yield = 760/a). 'H NMR (250 MHz, DMSO) 8: 2.95 (in, 2H); 2.51 (in, 2H); 2.42 (in, 1OH) 2.05 Cd, 2H); 1.54 Cm, 3H); 1.03 Cm, 2H) ; 0.99 Ct, 3H). PREPARATION 000(1 4-[(hexahydro-4-methyl- 1H- 1,4-diazepin-1-yI)methyl]- 1- piperidi ne-carboxylic acid, 1, 1-dimethylethyl ester In operating analogously to preparation LXXIX, starting with N-methylhomopiperazine, the product sought after is obtained as a colourless oil (yield = 830/a). 'H NMR (300 MHz, DMSO) 8 : no 'H NMR PREPARATION LXXXII 4-[(hexahydro-4-methyl- 1H-1,4-diazepin- 1-yI)methyl]pi peridi ne In operating analogously to preparation XXIX, starting with the ester obtained following preparation 1)00(1, the product sought after is obtained as a colourless oil (yield = 23%). 'H NMR (250 MHz, DMSO) 6: 3.03 Cm, 2H) ; 2.57 Cm, 5H); 2.50 Cm, SH) 2.25 Cs, 2H); 2.22 Cs, 3H); 1.68 Cm, 4H); 1.63 Cm, 1H); 1.08 (in, 2H). PREPARATION LXX)(III 4-(hexahydro-4-methyl- 1H-1,4-diazepin-1-yI)-1-piperidinecarboxylic acid, 1,1-dimethylethyl ester In operating analogously to preparation L)0(I, starting with N-methylhomopiperazine and the t-butyl ester of 4-oxo-1-piperidinecarboxylic acid, the product sought after is obtained as a yellow oil (yield = 360bo). 'H NMR (250 MHz, CDCI3) 8: 4.15 (in, 2H) ; 2.82 Cm, 4H) ; 2.70 (in, 7H) 2.42 Cs, 3H); 1.87 (in, 2H); 1.98 (in, 2H); 1.45 Cs, 9H); 1.40 (in, 2H). PREPARATION LXXXIV 4-(hexahydro-4-methyl- 1H-1,4-diazepin- 1-yI)piperidine, trihydrochioride 409 mg (1.37 mM) of the compound obtained according to preparation LXXXIII are dissolved in 1 ml of methanol and 27 ml of a 2.3 N solution of hydrogen chloride in ethyl acetate are added. The mixture is agitated at ambient temperature for 12 hours and then concentrated under reduced pressure. The product sought after is thus obtained as a beige foam (yield = 990/o) 'H NMR (250 MHz, DMSO) 8: 3.88 (in, 4H); 3.62 Cm, 1H); 3.43 (in, 6H) 2.94 (in, 2H) ; 2.82 Cs, 3H); 2.31 (in, 4H); 2.10 (in, 2H). PREPARATION L)OO(V 4-(4-cyclopropyl- 1-piperazinyl)-1-piperidinecarboxylic acid, phenylmethyl ester In operating analogously to preparation LXXI, starting with Ncyclopropylpiperazine, the product sought after is obtained as a white solid (yield = 62%). M.Pt. = 64GC PREPARATION LXXXVI 4-(4-cyclopropyl-1-piperazinyl)piperidine In operating analogously to preparation L)O(II, starting with the ester obtained following preparation LXXXV, the product sought after is obtained as a white solid (yield = 90%). M.Pt. = 1070C PREPARATION LXXXVII 4-[4-(1, 1-dimethylethyl)- 1-piperazinyl]- 1-piperidinecarboxylic acid, phenylmethyl ester In operating analogously to preparation LXXI, starting with N-tbutylpiperazine, the product sought after is obtained as a white solid (yield = SO0bo). M.Pt. = 840C PREPARATION LXXXVIII 4-[4-( 1, 1-dimethylethyl)- 1- piperazinyl] piperidine In operating analogously to preparation LXXII, starting with the ester obtained following preparation LXXXVII, the product sought after is obtained as a white solid (yield = 750/o). M.Pt. = 82GC PREPARATION L)OO(IX 4-(4-piperidinyl)- 1-piperidinecarboxylic acid, 1,1-dimethylethyl ester A solution is prepared of 41 g (0.17 M) of 4,4'-bipiperidine dihydrochloride in 250 ml of ethanol and 250 ml of 2N sodium hydroxide. A solution of 18.5 g (0.085 M) of t-butyl dicarbonate in 100 ml of ethanol are added slowly, at 0 0C. The reaction mixture is agitated for 1 hour at 1OGC and the ethanol is then removed by an evaporator, under reduced pressure. The residual aqueous phase is saturated with sodium chloride and extracted with ethyl acetate. The organic phase obtained is dried over magnesium sulphate and concentrated under reduced pressure. The crude product is purified by silica gel chromatography in eluting with the aid of a dichloromehane/methanol/aqueous ammonia mixture (8/2/0.4; v/v/v). 16.5 g of the compound sought after are thus obtained as a white solid (yield = 72 %). M.Pt. = 70-710C PREPARATION XC 4-( 1-ethyl-4-piperidinyl)- 1-piperidinecarboxylic acid, 1,1-dimethylethyl ester In operating analogously to preparation LXXI, starting with the ester obtained following preparation LXXXIX and acetaldehyde, the product sought after is obtained as a white solid (yield = 870bo). M.Pt. = 68-70 0C PREPARATION XCI 4-(1-ethyl-4-piperidinyl)piperidine, dihydrochioride In operating analogously to preparation LXXXIV, starting with the ester obtained following preparation XC, the product sought after is obtained as a white solid (yield = lOOObo). M.Pt. = 2800C PREPARATION XCII 4-[1-(1-methylethyl)-4-piperidinyl]- 1-piperidinecarboxylic acid, 1,1-dimethylethyl ester In operating analogously to preparation XC, starting with the ester obtained following preparation LXXXIX and acetone, the product sought after is obtained as a colourless oil (yield = 'H NMR (250 MHz, CDCI3) 8: 4.10 Cm, 2H) ; 3.52 Cm, 1H); 3.47 Cm, 2H) 2.55 Cm, 4H); 1.88 Cm, 4H); 1.85 Cm, 4H); 1.45 Cs, 9H); 1.30 Cd, 6H); 1.12 (in, 2H). PREPARATION XCIII 4-[1-(1-methylethyl)-4-piperidinyl]piperidine, dihydrochioride In operating analogously to preparation LXXXIV, starting with the ester obtained following preparation XCII, the product sought after is obtained as a white solid (yield = 890h). M.Pt. = 2500C PREPARATION XCIV 4-( 1-cyclopropyl-4-piperidinyl)- 1-piperidinecarboxylic acid, 1,1-dimethylethyl ester 150 mg (0.56 mM) of the compound obtained according to preparation LXXXIX are dissolved in 5 ml of methanol and 320 p1 of acetic acid and 200 mg of 3A molecular sieves, and then 562 p1(2.79 mM) of 1-ethoxy-1-(trimethylsilyloxy)cyclopropane and 141 mg (2.23 mM) of sodium borohydride, are added. The reaction mixture is heated under gentle reflux for 20 hours, and then cooled and filtered. The filtrate is concentrated under reduced pressure and the residue from evaporation is taken up into 20 ml of ethyl acetate. This organic phase is washed with a 2N solution of sodium hydroxide, and then with a saturated solution of sodium chloride, dried over magnesium sulphate and concentrated under reduced pressure. The crude product is purified by silica gel chromatography in eluting with the aid of a dichloromehane/methanol mixture (95/5; v/v). 110 mg of the compound sought after are thus obtained as a white powder (yield = 64 %). 'H NMR (250 MHz, CDCI3) 8: 4.10 (in, 2H); 3.05 (in, 4H); 2.65 Ct, 2H); 2.09 Ct, 2H) ; 1.67 Cm, 4H) ; 1.55 (in, 1H) ; 1.45 (s, 9H) ; 1.22 (in, 6H) 0.47 (in, 4H). PREPARATION XCV 4-(1-cyclopropyl-4-piperidinyl)piperidine, dihydrochioride In operating analogously to preparation LXXXIV, starting with the ester obtained following preparation XCIV, the product sought after is obtained as a white paste (yield = 99%). 'H NMR (250 MHz, DMSO) 8: 10.50 (in broad, 1H); 8.80 Cm broad, 2H); 3.45 (in, 2H); 3.16 (in, 2H) ; 2.81 (in, 2H) ; 2.73 (in, 3H); 1.90 (in, 4H); 1.60 Cm, 2H); 1.35 (in, 4H); 1.10 (in, 2H); 0.78 Cm, 2H). PREPARATION XCVI 4-[2-(4-piperidinyl)ethyl]-1-piperidinecarboxylic acid, 1,1-dimethylethyl ester In operating analogously to preparation LXXXIX, starting with 4,4'-ethylenedipiperidine hydrochloride, the product sought after is obtained as a white solid (yield = 390h). M.Pt. = 92-940C PREPARATION XCVII 4-[2-(1-methyl-4-piperidinyl)ethyl]piperidine A solution is prepared of 307 mg (1.04 mM) of the ester obtained following preparation XCVI in 20 ml of anhydrous tetrahydrofuran (ThF) and 157 mg (4.14 mM) of lithium aluminium hydride are added portionwise. The reaction mixture is agitated for 10 hours at 700C and then cooled and diluted with 30 ml of THF. 200 mg of Glauber's salt are added and the mixture is left under agitation at ambient temperature overnight, and then filtered. The filtrate is concentrated under reduced pressure to give 235 mg of the product sought after as a white paste (yield = 990bo). 'H•NMR (300 MHz, DM50) 8: 3.16 Cs, 2H); 2.80 Cm, 2H) ; 2.70 Cm, 2H); 2.38 Ct, 2H) ; 2.10 Cs, 3H) ; 1.76 (in, 2H) ; 1.58 Cm, 3H) ; 1.42 Cm, 1H) ; 1.11 Cm, 8H); 0.94 (in, 2H). PREPARATION XCVIII 4-[2-(4-methyl- 1-piperazinyl)ethyl]pyridine In a tube, 2 ml (19 mM) of 4-vinylpyridine, 3.16 ml (28.5 mM) of Nmethylpiperazine, and 200 p1 of acetic acid are mixed in 12 ml of ethanol. The tube is closed and heated for 10 minutes at 16OGC in a microwave oven. After cooling, 20 ml of 0.5N sodium hydroxide are added slowly and the mixture is extracted with dichloromethane. The separated organic phase is dried over magnesium sulphate and concentrated under reduced pressure. The product sought after is thus obtained as a yellow oil (yield = 86%). 'H NMR (250 MHz, DMSO) 8: 8.43 (dd, 2H); 7.25 (dd, 2H); 2.73 Ct, 2H); 2.52 (in, 2H); 2.48 (in, 4H) ; 2.30 Cm, 4H); 2.13 Cs, 3H). In operating analogously to preparation XCVIII, the following pyridine derivatives are obtained PREPARATION IC 4-[2-(1-piperidinyl)ethyt]pyridine yellow oil (yield = 52%) 'H NMR (250 MHz, DM50) 8: 8.43 (dd, 2H); 7.24 (dd, 2H); 2.73 Ct, 2H) 2.49 Cm, 2H) ; 2.37 Ct, 2H); 1.43 Cm, 6H). PREPARATION C 4-[2-[(methyl)(1-methylethyl)amino]ethyl]pyridine yellow oil (yield = 10%). 'H NMR (250 MHz, DMSO) 8: 8.49 Cd, 2H) ; 7.16 Cd, 2H); 2.76 (hep, 1H) 2.65 Ct, 2H); 2.56 Cd, 2H) ; 2.15 Cs, 3H); 0.90 Cd, 6H). PREPARATION CI 4-[2-(4-morpholinyl)ethyl]pyridine yellow oil (yield = 72%). 'H NMR (250 MHz, DMSO) 8: 8.44 (dd, 2H); 7.26 (dd, 2H); 3.05 (dd, 4H) ; 2.75 Ct, 2H); 2.53 Cm, 2H); 2.41 (dd, 2H). PREPARATION CII 4-[2-(1-azetidinyl)ethyl]pyridine yellow oil (yield = 620bo). 'H NMR (300 MHz, DMSO) 8: 8.43 (d, 2H); 7.22 (d, 2H); 3.07 Ct, 4H); 2.53 (in, 4H); 1.91 (quin, 2H). PREPARATION CIII (Methyl)[2-(4-pyridinyl)ethyl]carbamic acid, 1, 1-dimethylethyl ester yellow oil (yield = 830bo). 'H NMR (300 MHz, DMSO) 8: 8.45 Cd, 2H) ; 7.21 Cd, 2H); 3.42 Ct, 2H) 2.76 Ct, 2H) ; 2.75 (5, 3H); 1.23 Cs, 9H). PREPARATION CIV 4-(2-[(methyl)(ethyl)amino]ethyl]pyridine colourless oil (yield = 510bo). 'H NMR (300 MHz, DMSO) 8: 8.50 Cd, 2H) ; 7.25 Cd, 2H); 2.73 Ct, 2H) 2.55 Ct, 2H) ; 2.43 (q, 2H); 2.23 Cs, 3H); 0.90 (t; 3H). PREPARATION CV 4-[2-(diethylamino)ethyl]pyridine yellow oil (yield = 30~bo). 'H NMR (250 MHz, DMSO) 8: 8.43 (dd, 2H); 7.24 (dd, 2H); 2.65 (in, 4H); 2.40 (q, 4H) ; 0.93 Ct, 6H). PREPARATION CVI 4-[2-(hexahydro-4-methyl —1H- 1,4-diazepin- 1-yI)ethyl]pyridine yellow oil (yield = 520/o) 'H NMR (250 MHz, DMSO) 8: 8.43 Cd, 2H); 7.25 (d, 2H); 2.71 Cm, 8H); 2.50 Cm, 4H); 2.22 Cs, 3H); 1.68 Cm, 2H). PREPARATION CVII 4-[2-(4-methyl- 1-piperazinyl)ethyl]piperidine In operating analogously to preparation LXIX, starting with the compound obtained according to preparation XCVIII, the product sought after is obtained as a yellow solid (yield = 800/o). M.Pt. = 111-112 0C PREPARATION CVIII 4-[2-(dimethylamino)ethyljpiperidine In operating analogously to preparation CVII, starting with 4-[2-(dimethylamino)ethyl]pyridine, the product sought after is obtained as a colourless oil (yield = 960/a). 'H NMR (300 MHz, DMSO) 8: 2.86 (2H); 2.39 Cdt, 2H); 2.18 Cdd, 2H); 2.08 Cs, 6H); 1.54 (din, 2H); 1.27 (in, 3H) ; 0.96 Cm, 2H). PREPARATION CIX 4-[2-(1-pyrrolidinyl)ethyl]piperidine In operating analogously to preparation CVII, starting with 4-[2-(1-pyrrolidinyl)ethyl]pyridine, the product sought after is obtained as a colourless oil (yield = 880/o). 'H NMR (300 MHz, DMSO) 8: 2.86 (din, 2H); 2.38 (in, 8H) ; 1.64 (in, 4H) 1.54 (din, 2H); 1.32 Cm, 3H) ; 0.96 (dq, 2H). In operating analogously to preparation CVII, starting with the compounds obtained according to preparations IC to CVI, the following piperidine derivatives are obtained PREPARATION CX 4-[2-(1-piperidinyl)ethyl]piperidine yellow oil (yield = 920bo). 'H NMR (300 MHz, DMSO) 8: 3.10 (din, 2H); 2.67 Cdt, 2H); 2.27 Cm, 6H); 1.70 Cm, 2H); 1.47 Cm, 5H); 1.35 (in, 4H); 1.23 Cm, 2H). PREPARATION CXI 4-[2-[(methyl)( 1-methylethyl)amrno]ethyl]piperidine yellow oil (yield = 960/o). 'H NMR (250 MHz, DMSO) 8: 3.10 Cd, 2H); 2.77 Cm, 1H); 2.60 Cm, 2H); 2.35 Ct, 2H); 2.10 Cs, 3H); 1.72 (in, 2H); 1.34 Cm, 1H); 1.29 Ct, 2H); 1.23 (in, 2H); 0.91 Cd, 6H). PREPARATION CXII 4-[2-(4-morpholinyl)ethyl]piperidine colourless oil (yield = 98%). 'H NMR (300 MHz, DMSO) 8: 3.54 Ct, 4H); 2.86 Cdt, 2H); 2.39 Cdt, 2H); 2.28 Cm, 4H); 2.25 Ct, 2H); 1.54 (din, 2H); 1.31 (in, 3H); 0.97 Cm, 2H). PREPARATION CXIII 4-[2-(1-azetidinyl)ethyl]piperidine colourless oil (yield = 740/o). 'H NMR (250 MHz, DMSO) 8: 3.16 Ct, 4H) ; 3.12 Cm, 2H); 2.65 Cm, 2H); 2.35 Ct, 2H); 1.94 (quin, 2H); 1.85 Cm, 2H); 1.35 (in, 1H) ; 1.23 Ct, 2H) ; 1.15 (in, 2H). PREPARATION CXIV (Methyl)[ 2-(4-piperidinyl)ethyl]carbamic acid, 1,1-dimethylethyl ester colourless oil (yield = 64%). 'H NMR (300 MHz, DMSO) 8: 3.16 Ct, 2H); 2.89 (din, 2H) ; 2.73 Cs, 3H) 2.40 Ct, 2H); 1.38 Cs, 9H); 1.35 Cm, 2H) ; 0.96 Cm, 2H). PREPARATION CXV 4-[2-[(methyl)(ethyl)amino]ethyl]piperidine colourless oil (yield = 98%). 'H NMR (300 MHz, DMSO) 8: 3.13 (in, 2H); 2.68 Cm, 2H); 2.32 (in, 4H) 2.11 (5, 3H) ; 1.85 (in, 2H) ; 1.51 Cm, 1H) ; 1.34 Ct, 2H) ; 1.24 Cm, 2H) 0.96 Ct, 3H). PREPARATION CXVI 4-[2-(diethylamino)ethyl]piperidine yellow oil (yield = 870/a). 'H NMR (250 MHz, DM50) 8: 2.87 (din, 2H) ; 2.40 (in, 8H) ; 1.54 (din, 2H); 1.26 Cm, 3H); 0.98 (in, 2H) ; 0.91 Ct, 6H). PREPARATION CXVII 4- [2-(hexahydro-4-methyt—1H- 1,4-d iazepin- 1-yI)ethyl]-piperidine yellow oil (yield = 790/a). 'H NMR (300 MHz, DMSO) 8: 2.89 Cd, 2H); 3.05 (in, 2H); 2.58 (in, 4H); 2.49 (in, 4H); 2.46 Cm, 4H); 2.21 Cs, 3H); 1.66 (in, 2H); 1.64 (in, 2H); 1.28 Cm, 3H); 0.99 (in, 2H). PREPARATION CXVIII 4-(2-hydroxy- 1, 1-dimethylethyl)- 1-piperidinecarboxylic acid, 1,1-dimethylethyl ester In operating analogously to preparation LXXXIX, starting with j34~-dimethyl-4-piperidineethanol, the product sought after is obtained as a colourless oil Cyield = 96~/o). 'H NMR (300 MHz, DMSO) 8: 4.41 Ct, 1H) ; 3.98 Cd, 2H) ; 3.13 Cd, 2H) 2.51 (in, 2H) ; 1.50 Cd, 2H) ; 1.38 Cs, 9H); 1.33 Cm, 1H) ; 1.04 (in, 2H); 0.93 Cs, 6H. PREPARATION CXIX 4-( 1, 1-dimethyl-2-oxoethyl)- 1-piperidinecarboxylic acid, 1, 1-dimethylethyl ester A solution is prepared of 68 p1(0.77 mM) of oxalyl chloride in 6 ml of anhydrous dichloromethane. 82.5 p1 of dimethylsulphoxide are added at —700C, and then, after 15 mm, ioo ing (0.39 mM) of the alcohol obtained according to preparation CXVIII in solution in 4m1 of dichloromethane are added. Then, after 5 mm, 270 p1 of triethylamine are added. The mixture is agitated 5 minutes at — 7OGC, and then left to come back to ambient temperature. After addition of 25 ml of ethyl acetate, this organic phase is washed with a 10% sodium bicarbonate solution, dried over magnesium sulphate and concentrated under reduced pressure. The crude product is purified by silica gel chromatography in eluting with the aid of a dichloromethane/ethyl acetate mixture (85/15; v/v). 80 ing of the compound sought after are thus obtained as a colourless oil (yield = 80 Gbo). 'H NMR (250 MHz, DMSO) 8: 9.44 Cs, 1H); 3.96 Cd, 2H); 2.59 (in, 2H); 1.69 Cm, 1H); 1.50 Cm, 2H); 1.38 Cs, 9H); 1.07 (in, 2H) ; 0.93 Cs, 6H). PREPARATION CXX 4-[2-( 1-azetidinyl)- 1, 1-dimethylethyl]- 1-piperidinecarboxylic acid, 1,1-dimethylethyl ester In operating analogously to preparation LXXI, starting with the compound obtained according to preparation CXIX and azetidine, the product sought after is obtained as a colourless oil (yield = 650bo). 'H NMR (300 MHz, DMSO) 8: 3.96 Cd, 2H); 3.13 Ct, 4H); 2.51 (in, 2H) 2.16 Cs, 2H); 1.92 Cquin, 2H); 1.55 Cd, 2H); 1.39 Cs, 9H); 1.35 Cm, 1H) 1.05 (in, 2H); 0.70 Cs, 6H). PREPARATION CXXI 4-[2-(1-azetidinyl)- 1, 1-dimethylethyl]piperidine, bis(trifl uoroacetate) 520 ing (1.75 mM) of the compound obtained according to preparation CXX are mixed with 3 ml of trifluoroacetic acid and 380 p.1 of anisole in 3 ml of dichloromethane. The mixture is agitated overnight at ambient temperature and then concentrated under reduced pressure. The residue is taken up into 20 ml of toluene and again concentrated under reduced pressure. The crude product is triturated in 4 ml of ethyl ether to give a solid which is separated off by filtration and dried. 683 ing of the compound sought after are thus obtained (yield = 92 %). M.Pt. = 138-140 0C PREPARATION CXXII 4-[2-(4-morpholinyl)- 1,1-dimethylethyl]-1-piperidinecarboxylic acid, 1,1-dimethylethyl ester In operating analogously to preparation CXX, starting with morpholine, the product sought after is obtained as a colourless oil (yield = 12%). 'H NMR (300 MHz, DMSO) 8: 3.97 Cd, 2H) ; 3.53 Ct, 4H); 2.57 (in, 2H); 2.41 Ct, 4H) ; 2.10 Cs, 2H) ; 1.60 Cd, 2H) ; 1.38 Cs, 9H) ; 1.29 Cm, 1H) 1.05 (in, 2H); 0.77 Cs, 6H). PREPARATION CXXIII 4-[2-(4-morpholinyl)-1, 1-dimethylethyl]piperidine, b is(trifl uoroacetate) In operating analogously to preparation CXXI, starting with the compound obtained according to preparation CXXII, the product sought after is obtained as a pale yellow solid (yield = 69 0bo). M.Pt. = 158-160 0C PREPARATION CXXIV 4-[2-(1-piperidinyl)-1,1-dimethylethyl] pyridi ne A suspension of 70 g (0.58 M) of 4-isopropylpyridine, 250 g (2 M) of piperidine hydrochloride and 85 g of paraformaldehyde in 600 ml of 95% ethanol is held under reflux for 48 hours. The reaction mixture is then concentrated under reduced pressure and the residue is taken up with 650 ml of 3N sodium hydroxide and extracted with thrice 250 ml of ethyl acetate. The combined organic phases are washed with a solution of sodium chloride, dried and concentrated under reduced pressure. The crude product is distilled under a vacuum of 1 mm Hg and the fraction collected between 80 and 125 0C is purified by silica gel chromatography in eluting with the aid of a toluene/isopropanol mixture (9/1 ; v/v). 21.4 g of the compound sought after are thus obtained as a clear yellow oil (yield = 17%). 'H NMR (300 MHz, CDCI3) ~: 8.49 Cd, 2H); 7.32 Cd, 2H); 2.53 Cs, 2H); 2.20 Ct, 4H); 1.39 (in, 4H); 1.36 Cm, 2H); 1.29 (5, 6H), PREPARATION CXXV 4-[2-( 1-piperidinyl)-1, 1-dimethylethyl]piperidine In operating analogously to preparation CVII, starting with the compound obtained according to preparation CXXIV, the product sought after is obtained as a yellow oil (yield = 33 0/a). 'H NMR (300 MHz, DMSO) 8: 2.94 (din, 2H); 2.37 Cm, 6H); 2.03 Cs, 2H); 1.45 Cm, 6H); 1.32 Cm, 2H) ; 1.18 (in, 1H); 1.05 (in, 2H); 0.74 Cs, 6H). In operating analogously to the preparations CXXIV and CXXV, the two following compounds are obtained PREPARATION CXXVI 4-[2-(1-pyrrolidinyl)- 1, 1-dimethylethyllpi peridi ne yellow oil (yield = 72 G/o). 'H NMR C250 MHz, DMSO) 6: 2.97 Cd, 2H); 2.55 (in, 4H); 2.48 (in, 2H); 2.26 Cs, 2H) ; 1.66 (in, 4H) ; 1.62 Cd, 2H) ; 1.29 Cm, 1H) ; 1.03 (in, 2H) 0.77 Cs, 6H). PREPARATION CXXVII 4-[2-(diethylamino)- 1, 1-dimethylethylJpiperidine colourless oil(yield = 79 0/a). 'H NMR (300 MHz, DMSO) 8: no 'H NMR PREPARATION CXXVIII N,1-dimethyl-N-[1-(phenylmethyl)-4-piperidinyl]-4- piperidinamine In operating analogously to preparation LXXI, starting with N-methyl-4-piperidinone and 1-benzyl-4-(methylamino)piperidine, the product sought after is obtained as a yellow oil (yield = 66 Obo). 'H NMR (300 MHz, DM50) 8: 7.28 (in, 5H); 3.41 Cs, 2H); 2.76 Cm, 4H); 2.40 (in, 2H); 2.12 Cs, 3H); 2.10 Cs, 3H); 1.90 Cdt, 2H); 1.81 Cdt, 2H); 1.57 (din, 4H); 1.44 (in, 4H). PREPARATION CXXIX N, 1-dimethyl- N-(4-piperidinyl)-4-piperidinamine A solution is prepared of 980 mg (3.25 mM) of the compound obtained according to preparation CXXVIII in 60 ml of methanol and 150 ing of 10% palladium on carbon are added. The mixture is agitated under an atmosphere of hydrogen, under a pressure of 50 PSI (3.5 bars or 3450 hPa), at ambient temperature for 10 hours. The catalyst is removed by filtration and the filtrate is concentrated under reduced pressure. The crude product obtained is purified by silica gel chromatography in eluting with the aid of a dichloromethane/methanol/aqueous ammonia mixture (97/3/0.3; v/v/v). The product sought after is obtained as a yellow oil (yield = 29 G/o). 'H NMR (250 MHz, DMSO) 8: 2.94 (d, 2H); 2.76 Cd, 2H) ; 2.43 Cm, 4H); 2.12 Cs, 3H) ; 2.10 Cs, 3H) ; 1.81 Cm, 2H) ; 1.76 Cm, 4H) ; 1.45 (in, 2H) ; 1.30 (in, 2H). PREPARATION CXXX 4- [2-oxo-2-(4-methyl- 1-piperazinyl)ethyl] pyridine A solution is prepared of 3 g (17.3 mM) of (4-pyridinyl)acetic acid in 50 ml of tetrahydrofuran (THF) and, at ambient temperature, a solution of 3.4 g (20.7 mM) of carbonyldiimidazole in solution in 50 ml of ThE, is added dropwise. The reaction mixture is agitated for 8 hours, and a solution of 1.73 g (17.3 mM) of N-methylpiperazine in 20 ml of THE is then added. The reaction mixture is heated under reflux of the solvent for 2 hours, and then concentrated under reduced pressure. The residue from evaporation is taken up with 80 ml of 3N sodium hydroxide and extracted with ethyl acetate. The organic phase is dried over magnesium sulphate and concentrated under reduced pressure. The crude product is purified by silica gel chromatography in eluting with the aid of a dichloromethane/methanol mixture (99/1 ; v/v). The product sought after is obtained as a colourless oil (yield = 28 0/a). 'H NMR (250 MHz, DM50) 8 : 8.47 (dd, 2H); 7.23 Cdd, 2H); 3.75 Cs, 2H) 3.46 Ct, 2H); 2.23 Ct, 4H); 2.15 (3H), PREPARATION CXXXI 4-[2-oxo-2-(4-methyl- 1-piperazinyl)ethyl]piperidine In operating analogously to preparation CVII, starting with the compound obtained according to preparation CXXX, the product sought after is obtained as a colourless oil (yield = 59 G/~) 'H NMR (250 MHz, DMSO) 8: 3.42 Ct, 4H); 3.28 (in, 2H); 2.87 Cdt, 2H); 2.41 Cdt, 2H); 2.24 Cm, 6H); 2.16 Cs, 3H); 1.71 Cm, 1H); 1.54 (din, 2H); 1.06 (dq, 2H). In operating analogously to Examples 3 and 4, starting with the acids and amines obtained above (or from amines known from the literature), the following compounds according to the invention are obtained Exam~Ie 16 N-[2-[2-[4-[3-(1-azetidinyl)propyl]-1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy- N,2, 6-trimethylbenzenesulphonamide, difumarate Beige solid (yield = 34 G/~4 M.Pt. = 82 GC ExamDIe 17 N-[2-[2-[4-(1-methyl-3-piperidinyl)- 1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy-N,2,6-trimethylbenzenesul phonamide, difumarate White solid (yield = 36 0/a). M.Pt. = 60-65 GC Example 18 N-[2-[2-[4-(1-methyl-4-piperidinyl)-1-piperazinylJ-2-oxo-ethoxy]ethyl]-4-methoxy-N-cyclopropyl-2,6-dimethylbenzenesulphonamide, difumarate White solid (yield = 51 0h). M.Pt. = 185 0C Example 19 N-[2-[2-[4-[2-( 1-pyrrolidinyl)ethyl]- 1-piperazinyl]-2-oxo- ethoxy]ethyl]-4-methoxy-N-cyclopropyl-2,6-dimethylbenzenesulphonamide, difumarate White solid (yield = 420/o). M.Pt. = 141 0C Example 20 N-[2-l12-[4-[(1-methyl-2-imidazolyl)methyl]- 1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy- N,2, 6-trimethylbenzenesulphonamide, difumarate White solid (yield = 45 0bo). M.Pt. = 60-65 GC Example 21 N-[2-[2-[4-(1-methyl-4-piperidinyl)- 1-piperazinyl]-2-oxo-ethoxyjethyl ]-4-methoxy- N-ethyl- 2,6-dimethylbenzenesulphonamide, difumarate White solid (yield = 48 0b~). M.Pt. = 206 0C Example 22 N-112-[2-[4-[3-(dimethylamino)propyl]- 1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy-N-ethyl-2,6-dimethylbenzenesulphonamide, difumarate White solid (yield = 26 G/~). M.Pt. = 600C Example 23 N-[2-112-[4-(9-methyl-9-azabicyclo[3.3. 1]non-3-yI)- 1-piperazinyl]- 2-oxo-ethoxy]ethyl]-4-methoxy- N, 2,6-trimethylbenzenesulphonamide, fumarate White solid (yield = 73 %). M.Pt. = 96 0C Example 24 N-[2-[2-[4-[3-(1-pyrrolidinyl)propyl]- 1-piperazinylJ-2-oxo-ethoxy]ethylJ-4-methoxy- N-ethyl-2,6-dimethylbenzenesulphonamide, difumarate White solid (yield = 63 %). M.Pt. = 650C Example 25 N-[2-[2-[4-[3-(1-pyrrolidinyl)propyl]-1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy-N-cyclopropyl-2,6-dimethylbenzenesulphonamide, difumarate Ecru solid (yield = 61 %). M.PT. = 550C Example 26 N-[2-[2-[4-(8-cyclopropyl-8-azabicyclo[3.2. 1]oct-3-yI)- 1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy- N,2,6-trimethylbenzenesulphonamide, fumarate White solid (yield = 810/a). M.Pt. = 750C Example 27 N-[2-[2-114-(8-methyl-8-azabicyclo[3 .2. 1]oct-3-yI)- 1-piperazinyl]- 2-oxo-ethoxy]ethyl]-4-methoxy- N-ethyl-2,6- dimethylbenzenesulphonamide, difumarate White solid (yield = 64G/o). M.Pt. = 185GC Example 28 N-[2-[2-[4-(8-methyl-8-azabicyclo[3 .2. 1]oct-3-yI)-1-piperazinyl]- 2-oxo-ethoxy]ethyl]-4-methoxy- N-cyclopropyl-2,6- dimethylbenzenesulphonamide, difumarate White solid (yield = Sl0/o). M.Pt. = 1600C Example 29 N-[2-[2-[4-( 1-cyclopropyl-4-piperidinyl)- 1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy- N,2,6-trimethylbenzenesul phona m ide, difumarate White solid (yield = 600/o). M.Pt. = 112-1140C Example 30 N-[2-[2-[4-(8-methyl-8-azabicyclo[3 .2. l]oct-3-yI)- 1-piperazinyl]- 2-oxo-ethoxy]ethyl]-4-methoxy- N-( 1-methylethyl)-2,6- dimethylbenzenesulphonamide, difu marate White solid (yield = 600/o). M.Pt. = 1680C Example 31 N-[2-[2-[4-(1-ethyl-4-piperidinyl)- 1-piperazinyl]-2-oxo-ethoxyjethyl]-4-methoxy- N, 2,6-trimethylbenzenesulphonam ide, fumarate Beige solid (yield = 480/a). 'H NMR (250 MHz, DMSO) 8: 6.80 Cs, 2H); 6.53 Cs, 2H); 4.05 Cs, 2H); 3.80 Cs, 3H); 3.53 Ct, 2H); 3.39 (in, 2H); 3.29 Cm, 2H); 3.22 Ct, 2H); 3.12 Cm, 2H); 2.70 Cs, 3H); 2.62 (q, 2H); 2.53 Cs, 6H); 2.48 Cm, 4H); 2.29 (in, 3H); 1.77 (in, 2H); 1.52 Cm, 2H); 1.07 Ct, 2H). Example 32 N-[2-[2-[4-[ 1-(1, 1-dimethylethyl)-4-piperidinyl]-1- piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy- N,2,6-trimethylbenzene-suiphonamide, difumarate White solid (yield = 410/a). M.Pt. = 2300C Example 33 N-[2-[2-[4-[(1-methyl-4-piperidinyl)methyl]- 1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy- N,2,6-trimethyl benzenesuiphonamide, fumarate Yellow solid (yield = 62%). M.Pt. = 500C Example 34 N-[2-[2-[4-[3-(dimethylamino)propyl]- 1-piperazinyl]-2-oxo-ethoxy]ethyl]-2,6-dichloro—4-methoxy-N-methyl-benzene-suiphonamide, difumarate White solid (yield = 78 0/a). M.Pt. = 600C Example 35 N-[2-[2-[4-( 1-methyl-4-piperidinyl)- 1-piperazinyl]-2-oxo-ethoxy]ethyl]-2,6-dichloro—4-methoxy-N-methyl-benzene-suiphonamide, difumarate White solid (yield = 69 %). M.Pt. = 125GC Example 36 N-[2-[2-[4-[2-(1-methyl-4-piperidinyl)ethyl]-1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy-N,2,6-trimethylbenzene-suiphonamide, difumarate Ecru solid (yield = 620/a). M.Pt. = 900C Example 37 N-[2-[2-[4-(1-methyl-4-piperidinyl)hexahydro- 1H- 1,4-diazepin-1-yI]- 2-oxo-ethoxy]ethyl]-4-methoxy- N, 2,6-trimethylbenzenesulphonamide, fumarate White solid (yield = 560/a). M.Pt. = 530C Example 38 N-[2-[2-[4-(1-methyl-4-piperidinyl)- 1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy-N-(1-methylethyl)-2,6-dimethylbenzenesulphonamide, difumarate White solid (yield = 41 a/a). M.Pt. = 170 GC ExamDie 39 N-[2-[2-[4-[ 1-( 1-methylethyl)-4-piperidinyl]- 1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy- N,2,6-trimethylbenzenesulphonamide, fumarate White solid (yield = 810/a). M.Pt. = 130 GC Example 40 N-[2-[2-[4-[3-( 1-piperidinyl)propyl]- 1-piperazinyl]-2-oxo-ethoxyjethyl ]-4-methoxy-N -ethyl- 2,6-dimethylbenzenesulphonamide, difumarate Ecru solid (yield = 600/a). M.Pt. = 650C Example 41 N-[2-[2-[4-( 1-methyl-4-piperidinyl)-1-piperazinyl]-2-oxo-ethoxy]ethylJ-2,4-dichloro—6-methoxy-N-methyl-benzene-suiphonamide, difumarate White solid (yield = 46 0/a). M.Pt. = 202 0C Example 42 N-[2-[2-[4-(1-ethyl-4-piperidinyl)- 1-piperazinylJ-2-oxo-ethoxy]ethyl]-2,6-dichloro—4-methoxy-N-methyl-benzene-suiphonamide, fumarate White solid (yield = 68 %). M.Pt. = 96-98 0C Example 43 N-[2-[2-[4-((3S)- 1-azabicyclo[2.2.2]oct-3-yI)-1-piperazinyl]-2- oxo-ethoxy]ethyl]-4-methoxy- N-methyl- 2,6-dichlorobenzenesulphonamide, fumarate White solid (yield = 36 %). M.Pt. = 75~79 GC In operating analogously to Example 2, starting with the acids and amines obtained above (or from amines known from the literature), and by using the acid which is adapted for the salification of the purified basic compound, the following compounds according to the invention are obtained: Example 44 N-[2-[2-[4-(1,2,2,6,6-pentamethyl-4-piperidinyl)- 1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy-N,2,6-trimethylbenzene-suiphonamide, bis(trifluoroacetate) Colourless oil (yield = 370/a). 'H NMR (300 MHz, CD3CN) 6 : 8.70 Cm broad, 1H) ; 6.75 (5, 2H); 4.10 (5, 2H) ; 3.80 (5, 3H) ; 3.76 Cm, 4H) ; 3.70 Ct, 1H) ; 3.61 Ct, 2H) ; 3.28 (ni, 4H) ; 2.27 Cs, 6H) ; 2.57 Cs, 6H) ; 2.28 (din, 4H) ; 1.47 Cs, 6H) ; 1.38 Cs, 6H). Example 45 N-[2-112-[4-[3-(4-methyl- 1-piperazinyl)propyl]- 1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy- N, 2,6-trimethylbenzene-suiphonamide, difumarate White solid (yield = 300/a). M.Pt. = 204 0C Example 46 N-[2-[2-[4-(8-ethyl-8-azabicyclo[3.2. 1]oct-3-yI)- 1- piperazinyl]-2-z~xo-ethoxy]ethyI]-4-methoxy- N,2,6-trimethyl benzenesuiphonamide, difumarate White solid (yield = 270/a). M.Pt. = 1320C Example 47 N -[2- [2-[4- [3-(4-methyl- hexahydro- 1H- 1,4-d iazepin- 1-yI)propyl]- 1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy-N,2,6-trimethylbenzenesu Iphonamide, difumarate White solid (yield = 450/a). M.Pt. = 169 0C Example 48 N-[2-[2-[4-(8-(1-methylethyl)-8-azabicyclo[3.2.1]oct-3-yI]-1-piperazinyl]-2-oxo-ethoxy]ethyl] -4- methoxy- N,2,6-trimethylbenzenesulphonamide, difumarate White solid (yield = 350/a). M.Pt. = 1320C Example 49 N-[2-[2-[4-[3-(4-methyl-hexahydro- 1H- 1,4-diazepin- 1-yI)-3-oxo-propyl]- 1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy-N,2,6-trimethylbenzenesulphonamide, bis(trifluoroacetate) Colourless oil (yield = 35a/a). 'H NMR (300 MHz, CD3CN) 8: 6.76 Cs, 2H); 4.15 Cs, 2H); 3.84 Cs, 3H); 3.82 Cm, 6H); 3.65 Ct, 2H); 3.62 Cm, 2H); 3.44 Ct, 2H); 3.36 (in, 1OH); 2.90 Ct, 2H); 2.87 Cs, 3H); 2.77 Cs, 3H) ; 2.61 (5, 6H) ; 2.18 Cm, 2H). Example 50 N -[2-[2-[4- [2-(4-methyl-hexahydro- 1H- 1,4-d iazepi n- 1-yI)ethyl]- 1-pi perazinyl ]-2-oxo-ethoxy]ethyl]-4-methoxy- N, 2,6- trimethylbenzenesulphonamide, trifumarate White solid (yield = 8 0/a). M.Pt. = 176 0C In operating analogously to Examples 5 and 4, starting with the acids obtained above, the two following compounds according to the invention are obtained Example 51 N-[2-[2-[4-((3S)-1-azabicyclo[2.2.2]oct-3-yI)-1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy-N-cyclopropyl-2,6-dimethylbenzenesulphonamide, difumarate White solid (yield = 37 %). M.Pt. = 72 0C [aD25] = -11.4 0 Cc = 0.5 ; CH3OH) Example 52 N-[2-[2-[4-((3S)- 1-azabicyclo[2.2.2]oct-3-yI)- 1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy-N-ethyt- 2,6-dimethylbenzenesulphonamide, difumarate White solid (yield = 32 %). M.Pt. = 70 0C = ~ Cc = 0.5; CH3OH) In operating analogously to Example 1, starting with the acid obtained according to preparation III and 1-[2-(diethylamino)ethyl]piperazine, the following compound according to the invention is obtained Example 53 N -[2-[2-[4-[2-(diethylamino)ethyl]- 1-piperazinyl]-2-oxo- ethoxyjethyl ]-4-methoxy- N, 2, 6-trimethylbenzenesu Iphonam ide, fumarate White pasty solid (yield = 77 0/a). 'H NMR (300 MHz, CD3CN) 8: 6.74 Cs, 2H); 6.60 Cs, 2H); 4.02 Cs, 2H); 3.80 Cs, 3H); 3.54 Ct, 2H); 3.46 (in, 2H); 3.32 (in, 2H); 3.26 Ct, 2H); 2.96 (in, 6H); 2.74 Cs, 3H); 2.62 Ct, 2H); 2.57 Cs, 6H); 2.41 Cm, 4H); 1.16 Ct, 6H). PREPARATION CXXXII [2-[methyl(phenylmethyl)amino]ethoxy]acetic acid, 1, 1-dimethylethyl ester In operating analogously to preparation II, starting with 2-[methyl(phenylmethyl)amino]ethanol, the product sought after is obtained as a colourless oil (yield = 35 0/~~). 'H NMR (250 MHz, DMSO) 8: 7.26 (in, SH); 3.96 Cs, 2H) ; 3.57 Ct, 2H) 3.49 (5, 2H); 2.49 (in, 2H) ; 2.14 Cs, 3H); 1.40 (s, 9H). PREPARATION CXXXIII [2-[methyl(phenylmethyl)amino]ethoxy]acetic acid, lithium salt A solution of ig (3.58 mM) of the compound obtained according to preparation CXXXII in 10 ml of tetrahydrofuran is heated under the reflux of the solvent in the presence of 165 ing of lithia and 3 ml of water, for 8 hours. The reaction mixture is then concentrated under reduced pressure to give the product sought after as a colourless foam (yield = 99 %). 'H NMR (250 MHz, DMSO) 8: 7.26 (in, SH) ; 3.59 Cs, 2H) ; 3.53 Ct, 2H) 3.48 Cs, 2H) ; 2.50 Ct, 2H); 2.12 Cs, 3H). PREPARATION CX)O(IV N-methyl- N-[2-[2-[4-(1-methyl-4-piperidinyl)- 1-piperazinyl]-2-oxoethoxy]ethyl]- benzenemethanamine In operating analogously to Example 5, starting with the salt obtained according to preparation CXXXIII and 1-C 1-methyl-4-piperidinyl)piperazine, the product sought after is obtained as a yellow oil (yield = 24 %). 'H NMR (250 MHz, DM50) 8: 7.26 Cm, SH); 4.09 Cs, 2H); 3.54 Ct, 2H); 3.49 Cs, 2H); 3.37 (in, 4H); 2.78 Cm, 2H); 2.53 Ct, 2H); 2.43 (in, 4H); 2.41 Cs, 3H); 2.11 Cs, 3H); 2.07 (in, 1H); 1.80 Cdt, 2H) ; 1.65 (din, 2H); 1.39 Cdq, 2H). PREPARATION CXXXV N-methyl-2-[2-[4-(1-methyl-4-piperidinyl)- 1-pi perazinyl]-2-oxoethoxyjethanamine In operating analogously to preparation XXXV, starting with the compound obtained according to preparation CXXXIV, the product sought after is obtained as a yellow oil (yield = 80 0/a). 'H NMR (300 MHz, DMSO) 8: 4.16 Cs, 2H); 3.55 Ct, 2H); 3.49 (in, lH); 3.39 Cm, 2H); 3.33 (in, 2H); 2.77 Ct, 4H); 2.43 Cm, 2H); 2.38 (s, 3H); 2.16 (in, 2H); 2.12 Cs, 3H); 1.82 Cdt, 2H); 1.67 (din, 2H); 1.38 (dq, 2H). PREPARATION CXXXVI 2,6-dichloro-4-fluorobenzenesulphonyl chloride A solution of 4.75g (25 mM) of 2,6-dichloro-4-fluoroaniline in 50 ml of dichloromethane are added, at —150C, to 4.75 ml of boron trifluoride etherate. 5 ml of tetrahydrofuran are added to dissolve the precipitate formed, then, slowly, 3.6 ml of t-butyl nitrite in solution in 25 ml of dichloromethane are added. The reaction mixture is agitated 10 minutes at —15 0C and then 20 minutes at +50C. 200 ml of pentane are added, and agitation is maintained at 00C for 30 mm and the precipitate is filtered off. After drying, 7.2 g of the diazonium salt are obtained. This salt is dissolved in 30 ml of acetonitrile and is added, at 10 0C, to a mixture of a solution of sulphur dioxide in 90 ml of acetic acid to which 1.4 g of anhydrous copper (II) chloride and 23 ml of concentrated hydrochloric acid have been added. The reaction mixture is agitated 30 mm at ambient temperature and then concentrated under reduced pressure. The residue from evaporation is taken up into 60 ml of dichloromethane and the insoluble salts are removed by filtration. The filtrate is concentrated under reduced pressure to give 4.71 g of the product sought after as orange crystals (yield = 71 %). M.Pt. = 570C Example 54 N-[2-[2-[4-(1-methyl-4-piperidinyl)- 1-piperazinyl]-2-oxo-ethoxyjethyl]- 2,6-dichloro—4-tluoro-N -methyl-benzenesulphonamide In operating analogously to preparation I, starting with the compounds obtained according to preparations CXXXV and CXXXVI, the product sought after is obtained as a pale yellow oil (yield = 73 0/a). 'H NMR (250 MHz, DMSO) 8: 7.73 Cd, 2H) ; 4.08 (5, 2H); 3.58 Ct, 2H); 3.45 Ct, 2H); 3.40 (in, 2H); 3.30 Cm, 2H); 2.93 Cs, 3H); 2.78 Cm, 2H); 2.41 Cm, 4H); 2.13 (in, 1H) ; 2.11 (5, 3H); 1.81 Ct, 2H); 1.75 Cm, 2H) 1.40 (in, 2H). Example 55 N-[2-[2-[4-(1-methyl-4-piperidinyl)- 1-piperazinyl]-2-oxo-ethoxy]ethyl]-2,6-dichloro—4-fluoro-N-methyl-benzene-sulphonamide, difumarate In operating analogously to Example 4, starting with the compound obtained according to Example 54, the product sought after is obtained as a white solid (yield = 76 0/a). M.Pt. = 152-155 0C In operating analogously to Examples 54 and 55, starting with benzenesulphonyl chlorides having various substituents, the following compounds according to the invention are obtained Example 56 N-[2-[2-[4-(1-methyl-4-piperidinyl)- 1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-bromo-2,6-dichloro-N-methyl-benzenesulphonamide Colourless oil (yield = 37 0/4 'H NMR (300 MHz, DMSO) 8: 7.97 Cs, 2H); 4.07 Cs, 2H); 3.58 Ct, 2H); 3.45 Ct, 2H); 3.43 Cm, 2H); 2.99 Cs, 3H); 2.74 Cm, 2H); 2.42 Cm, 4H); 2.14 Cm, 1H); 2.13 Cs, 3H); 1.81 Ct, 2H); 1.76 Cm, 2H); 1.44 Cm, 2H). Example 57 N-[2-[2-[4-(1-methyl-4-piperidinyl)- 1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-bromo-2,6-dichloro-N-methyl-benzenesulphonamide, difumarate White solid (yield = 87 0/a). M.Pt. = 194 0C Example 58 N-[2-[2-[4-(1-methyl-4-piperidinyl)- 1-piperazinyl]-2-oxo-ethoxy]ethyl]-2,4,6-trichloro-N-methyl-benzenesulphonamide Colourless oil Cyield = 64%). 'H NMR (300 MHz, DMSO) 8: 7.88 Cs, 2H); 4.08 Cs, 2H); 3.58 Ct, 2H); 3.44 Ct, 2H); 3.38 Cm, 4H); 2.94 Cs, 3H); 2.78 (in, 2H); 2.42 Cm, 4H); 2.17 Cm, 1H) ; 2.11 Cs, 3H) ; 1.81 Ct, 2H) ; 1.76 (in, 2H) ; 1.44 (in, 2H). Example 59 N-[2-[2-[4-(1-methyl-4-piperidinyl)- 1-piperazinyl]-2-oxo-ethoxy]ethyl ]-2,4,6-trichloro-N-methyl- benzenesul phonam ide, difumarate White solid (yield = 82 %). M.Pt. = 194 0C Example 60 N-[2-[2-[4-(1-methyl-4-piperidinyl)-1-piperazinyl]-2-oxo-ethoxy]ethyl ]-2,4-d ichloro-6-methyl- N-methylbenzenesulphonamide Colourless oil (yield = 61 %). 'H NMR (300 MHz, DMSO) 8: 7.70 Cd, 1H) ; 7.56 Cd, 1H) ; 4.07 Cs, 2H); 3.57 Ct, 2H) ; 3.37 Cm, 2H) ; 3.30 Cs, 4H) ; 2.85 Cs, 3H) ; 2.74 Cm, 2H) 2.62 Cs, 3H) ; 2.42 (in, 4H) ; 2.13 (in, 1H) ; 2.11 Cs, 3H) ; 1.81 Ct, 2H) 1.77 (in, 2H); 1.43 Cm, 2H). Example 61 N-[2-[2-[4-(1-methyl-4-piperidinyl)- 1-piperazinyl]-2-oxo-ethoxy]ethyl]-2,4-d;chloro-6-methyl-N-methyl-benzenesulphonamide, difumarate White solid (yield = 87 %). M.Pt. = 190 0C Example 62 5 N-[2-[2-[4-(1-methyl-4-piperidinyl)- 1-piperazinyl]-2-oxo-ethoxy]ethyl ]-4-methoxy-2,3,6-trimethyl- N-methylbenzenesulphonamide Colourless oil (yield = 34 %). 'H NMR (250 MHz, DMSO) 8: 6.83 Cs, 1H); 4.03 Cs, 2H); 3.84 Cs, 3H) 10 3.52 Ct, 2H); 3.35 Cm, 2H) ; 3.35 Cm, 2H); 3.18 Ct, 2H); 2.73 Cm, 2H) 2.69 Cs, 3H); 2.57 (5, 3H); 2.42 Cs, 3H); 2.41 Ct, 4H); 2.12 Cs, 3H); 2.10 Cm, 1H); 2.08 Cs, 3H); 1.81 (in, 2H); 1.66 Cm, 2H); 1.38 Cm, 2H). Example 63 4-methoxy-N,2,3,6-tetra methyl- N-[2-[2-[4-( 1-methyl-4-pi peridinyl)- 1-piperazinyl]-2-oxo-ethoxy]ethyl] benzenesuiphonamide, difumarate White solid (yield = 71 %). M.Pt. = 180 0C PREPARATION CXXXVII 4-[[2-[[(4-methoxy-2,6-dimethylphenyl)sulphonyl] methylamino]ethoxy]acetyl]-1-piperazinecarboxylic acid, 1, 1-dimethylethyl ester In operating analogously to Example 5, starting with N-Boc-piperazine, the product sought after is obtained which is used in the next step without particular purification. PREPARATION CXXXVIII 4-methoxy- N,2,6-trimethyl- N- [2- [2-oxo-2-(1-piperazinyl)ethoxy]ethyl] benzenesulphonamide In operating analogously to preparation XXIX, starting with the compound obtained following preparation CXXXVII, the product sought after is obtained as a yellow oil (yield = 98 0/a). 'H NMR (250 MHz, DMSO) 8: 6.80 Cs, 2H); 4.04 Cs, 2H); 3.80 Cs, 3H); 3.53 Ct, 2H); 3.30 (in, 2H); 3.23 Ct, 4H); 2.70 Cs, 3H); 2.60 Ct, 4H); 2.53 Cs, 6H). PREPARATION CXXXIX 4-(3-oxopropyl)-1-piperidinecarboxylic acid, phenylmethyl ester 0.81 ml of dimethylsulphoxide in solution in 10 ml of dichloromethane (DCM) is cooled to —500C and 0.42 ml (4.8 mM) of oxalyl chloride in solution in 1.5 ml of DCM are added. The mixture is agitated for 10 minutes at —60 0C are then, at this temperature, 1.21g (4.4 mM) of the benzyl ester of 4-C3-hydroxypropyl)piperidinecarboxylic acid in solution in 6 ml of DCM are added dropwise. The reaction mixture is agitated for 30 minutes at — 500C and 3 ml of triethylamine are then added dropwise and the temperature is allowed to rise up to ambient temperature in 2 hours. The mixture is hydrolysed on 25 ml of N hydrochloric acid and extracted with DCM. The organic phase is washed with water, dried over magnesium sulphate and concentrated under reduced pressure. The crude product is purified by silica gel chromatography in eluting with the aid of a cyclohexane/ethyl acetate mixture (75/25; v/v). The product sought after is thus obtained as a yellow oil (yield = 830/a). 'H NMR (300 MHz, DMSO) 8: 9.66 Cs, 1H); 7.35 Cm, 5H) ; 5.05 (5, 2H) 3.98 Cm, 2H); 2.75 Cm, 2H); 2.44 (in, 2H); 1.64 (q, 2H); 1.63 (in, 2H); 1.37 (in, 1H); 1.02 Cm, 2H). PREPARATION CXL 4-[3-[4-[[2-[[(4-methoxy-2,6-dimethylphenyl)sulphonyl]methyl aminojethoxyjacetyl]- 1-piperazinyl]propyl]-1-piperidinecarboxylic acid, phenylmethyl ester In operating analogously to preparation XXVIII, starting with the compounds obtained following preparations CXXXVIII and CXXXIX, the product sought after is obtained as a colourless oil (yield = 51 %). 'H NMR (300 MHz, DMSO) 8: 7.40 Cm, SH) ; 6.81 (5, 2H); 5.05 (5, 2H) 4.33 Cs, 2H) ; 3.96 (in, 2H) ; 3.79 Cs, 3H) ; 3.55 Ct, 2H) ; 3.37 Cm, 2H) 3.30 Cm, 2H) ; 3.19 Ct, 2H) ; 2.71 Cm, 2H) ; 2.69 Cs, 3H) ; 2.52 Cs, 6H) 2.25 Cm, 6H); 1.65 (in, 2H); 1.42 Cm, 3H); 1.20 Cm, 2H); 1.00 Cm, 2H). Example 64 4-methoxy-N,2,6-trimethyl-N-[2-[2-oxo-2-[4-[3-(4-piperidinyl)propyl]- 1-piperazinyl]ethoxy]ethyl]benzene-suiphonamide In operating analogously to preparation )OO(V, starting with the compound obtained following preparation CXL, the product sought after is obtained as a colourless oil (yield = 62 0/a). 'H NMR (250 MHz, DMSO) 8: 6.80 Cs, 2H) ; 4.05 Cs, 2H); 3.80 Cs, 3H); 3.53 Ct, 2H); 3.30 Cm, 4H); 3.19 Ct, 2H); 2.88 Cm, 2H); 2.69 Cs, 3H); 2.50 Cs, 6H); 2.44 (in, 2H); 2.27 Cm, 6H); 1.57 (in, 2H); 1.41 (in, 3H); 1.17 (in, 2H); 0.97 (in, 2H). Example 65 4-methoxy- N,2,6-trimethyl- N-[2-[2-oxo-2-[4-[3-( 1-methyl-4-piperidinyl)propyl]- 1-piperazinyljethoxyjethyl] benzenesuiphonamide In operating analogously to preparation XXVIII, starting with the compound obtained following Example 64, the product sought after is obtained as a colourless oil (yield = 90 0/a). 'H NMR (250 MHz, DMSO) 8: 6.80 Cs, 2H); 4.05 Cs, 2H); 3.80 Cs, 3H); 3.53 Ct, 2H); 3.38 Cm, 2H); 3.24 Ct, 2H); 3.18 Cm, 2H); 2.72 (in, 2H); 2.69 Cs, 3H); 2.50 Cs, 6H); 2.28 Cm, 6H); 2.11 Cs, 2H); 1.78 Cm, 2H); 1.60 Cm, 2H); 1.45 Cm, 2H); 1.15 (in, 5H). Examole 66 4-methoxy- N,2,6-trimethyl- N- [2- [2-oxo-2-[4-[3-(1-methyl-4-piperidinyl)propyl]- 1-piperazinyl]ethoxy]ethyl]benzene-suiphonamide, difumarate In operating analogously to Example 4, starting with the compound obtained following Example 65, the product sought after is obtained as a white solid (yield = 98 %). M.Pt. = 50 GC PREPARATION CXLI 4-[4-(phenylmethyl)- 1-piperazinyl]- 1-piperidinecarboxylic acid, 1,1-dimethylethyl ester In operating analogously to preparation benzylpiperazine and N-Boc-4-piperidinone, obtained as a colourless oil (yield = 60 %). 'H NMR (300 MHz, CDCI3) 8: 7.27 Cm, 5H); 2.61 (in, 11H) ; 1.81 Cm, 2H) ; 1.44 Cs, 9H) ; PREPARATION CXLII 4-(1-piperazinyl)- 1-piperid inecarboxylic acid, 1, 1-dimethylethyl ester XXVIII, starting with N- the product sought after is 4.15 (in, 2H); 3.52 (s, 2H); 1.41 (in, 2H). A solution is prepared of 15.5 g (43.1 mM) of the compound obtained according to preparation CXLI in 46 ml of ethanol and 3.1 g of palladium hydroxide are added, and then, after rendering the reactor inert, 17.7 g (215 mM) of cyclohexene are added. The reaction mixture is agitated at 50 GC for 6 hours and then cooled and filtered. The filtrate is concentrated under reduced pressure and 10.02 g of the product sought after are obtained as a colourless oil(yield = 86 0/a). 'H NMR (300 MHz, CDCL3) 6: 4.12 (in, 2H); 2.92 Cm, 4H); 2.69 (in, 2H); 2.55 Ct, 4H); 2.36 Cm, 1H); 1.79 (in, 2H); 1.45 Cs, 9H); 1.38 (in, 2H). PREPARATION CXLIII 4-[4-[[2-[[(4-methoxy-2,6-dimethylphenyl)sulphonyl]-methylaminoethoxy]acetyl ]- 1-piperazinyl]- 1-piperidinecarboxylic acid, 1, 1-dimethylethyl ester In operating analogously to Example 3, starting with the compounds obtained following preparations III and CXLII, the product sought after is obtained as a colourless oil (yield = 32 0/a). 'H NMR (300 MHz, CD3CN) 8: 6.74 Cs, 2H) ; 4.07 (in, 2H); 4.00 Cs, 2H); 3.80 Cs, 3H); 3.54 Ct, 2H); 3.43 (in, 2H); 3.26 Cm, 4H); 2.74 Cs, 3H); 2.69 (in, 2H); 2.57 Cs, 6H); 2.44 Cm, 4H); 2.34 Cm, 1H); 1.71 Cm, 2H); 1.41 Cs, 9H); 1.29 (in, 2H). Examnle 67 4-methoxy-N,2,6-trimethyl- N-[2-[2-oxo-2-[4-(4-piperidinyl)- 1-piperazinyl]ethoxy]ethyl]benzenesulphonamide, bis(trifiuo roacetate) A mixture is prepared of 140 mg (0.24 mM) of the compound obtained according to preparation CXLIII in 1 ml of dichloromethane and 0.7 ml of trifluoroacetic acid. The reaction mixture is agitated at ambient temperature for 2 hours and then concentrated under reduced pressure. The residue from evaporation is taken up into 3 ml of water and is freeze-dried. 160 mg of the product sought after are thus obtained as a white solid (yield = 95 %). M.Pt. = 62 0C PREPARATION CXLIV 4-(6-nitro-3-pyridinyl)- 1-piperazinecarboxylic acid, 1,1-dimethylethyl ester A solution is prepared of 1 g (4.9 mM) of 2-nitro-5-bromopyridine and 917 mg (4.9 mM) of N-Boc-piperazine in 10 ml of dimethylformamide and 1.02 g (7.4 mM) of potassium carbonate are added. The reaction mixture is agitated at 1200C for 36 hours and then cooled. 50 ml of water are then added and extraction is carried out with ethyl acetate. The organic phase obtained is washed with water, dried and concentrated under reduced pressure. The crude product is purified by silica gel chromatography in eluting with the aid of a toluene/isopropanol mixture (98/2; v/v). The product sought after is thus obtained as a yellow solid (yield = 330/a). 'H NMR (250 MHz, DMSO) 8: 8.24 Cd, 1H); 8.17 Cd, 1H) ; 7.46 (dd, 1H); 3.50 Cm, 8H); 1.42 (5, 9H). PREPARATION CXLV 1-(6-nitro-3-pyridinyl)piperazine, bis(trifluoroacetate) In operating analogously to Example 67, starting with the compound obtained following preparation CXLIV, the product sought after is obtained as a yellow solid (yield = 97 0/a). M.Pt. = 188-190 GC PREPARATION CXLVI 4-methoxy- N,2,6-trimethyl- N-[2- [2-oxo-2- [4-(6- nitro-3-pyridinyl)- 1-piperazinyl]ethoxy]ethyl]benzenesulphonamide In operating analogously to Example 3, starting with the compounds obtained following preparations III and CXLV, the product sought after is obtained as a yellow solid (yield = 82 0/a). M.Pt. = 118-120 0C Example 68 4-methoxy-N,2,6-trimethyl-N-[2-[2-oxo-2-(4-(6-amino-3-pyridinyl)- 1-piperazinyl]ethoxy]ethyl] benzenesulphonam ide A suspension is prepared of 580 ing (1.11 mM) of the compound obtained following preparation CXLVI in 20 ml of methanol and 58 ing of 10% palladium on carbon are added. The reaction mixture is agitated at ambient temperature for 6 hours under an atmosphere of hydrogen at atmospheric pressure and is then filtered and concentrated under reduced pressure. The crude product is purified by silica gel chromatography in eluting with the aid of a dichloromethane/methanol mixture (97/3; v/v). The product sought after is thus obtained as a yellow pasty solid (yield = 81%). 'H NMR (300 MHz, DMSO) 8: 7.61 Cd, 1H); 7.17 (dd, 1H); 6.80 Cs, 2H); 6.40 (dd, 1H); 5.43 Cs, 2H); 4.11 Cs, 2H); 3.79 Cs, 3H); 3.55 Cm, 4H); 3.44 (in, 2H); 3.24 Ct, 2H); 2.87 (in, 4H); 2.70 Cs, 3H) ; 2.53 (s, 6H). Example 69 4-methoxy- N,2,6-trimethyl- N.[2- [2-oxo-2-[4-(6-amino-3-pyridinyl)- 1-piperazinyl]ethoxy]ethyl]benzenesutphonamide, fumarate In operating analogously to Example 4, starting with the compound obtained following Example 68, the product sought after is obtained as a beige solid (yield = 97 %). M.Pt. = 194-196 0C Example 70 N-[2-[2-[4-[2-(dimethylamino)-1, 1-dimethylethylj-1-p iperidinyl]-2-oxoethoxy]ethyl]-4-methoxy-N, 2,6- trimethylbenzenesulphonamide, trifluoroacetate 460 ing of polystyrene resin grafted with a cyclohexylcarbodiimide function are placed in 5 ml of DCM for 20 mm. The solvent is removed by filtration, and 100 mg (0.31 mM) of [2-[[(4-methoxy-2,6-dimethylphenyl)sulphonyl]methylamino]-ethoxy]acetic acid in solution in 3 ml of DCM, 37 ing (0.20 mM) of 4-[2-(dimethylamino)-1,1- dimethylethyl]piperidine and 2 ing of HOAT(1-hydroxy-7- azabenzotriazole), are then added. The mixture is agitated for 4 hours and then the resin is separated off by filtration and rinsed with 4 ml of DCM. The combined organic phases are treated with 50 ing of Amberlite IRA 400 resin (0H) for 3 hours, and then with 100 nig of isocyanate grafted polystyrene resin for 1 hour. The resin is removed by filtration and the filtrate is concentrated under reduced pressure. The product obtained is taken up into 0.5 ml of acetonitrile and 6 ml of a 1% solution of trifluoroacetic acid in water are added. The mixture is filtered and freeze-dried. 59 ing of the compound sought after are thus obtained as an amorphous solid (yield = 48 %). M.Pt. = 60 GC 'H NMR (250 MHz, CD3CN) 8: 6.74 Cs, 2H) ; 4.50 Cm, 1H); 4.06 Cm, 2H); 3.80 Cs, 3H); 3.78 (in, 1H); 3.57 Ct, 2H); 3.31 Ct, 2H); 3.04 (5, 2H); 2.85 Cs, 6H); 2.83 (in, 1H); 2.73 Cs, 3H); 2.56 Cs, 6H); 2.55 Cm, 1H); 1.65 Cm, 2H); 1.45 (in, 1H), 1.20 Cm, 2H); 0.99 Cs, 6H). Example 71 N-[2-[2-[4-[2-(dimethylamino)-1-hydroxyethyl]-1-piperidinyl]-2- oxoethoxy]ethyl]-4-methoxy- N, 2,6- trimethylbenzenesulphonamide, trifluoroacetate In operating analogously to Example 70, starting with the compound obtained according to preparation LXIX, the product sought after is obtained as a colourless paste (yield = 45 %). 'H NMR (250 MHz, CD3CN) 8: 6.74 Cs, 2H) ; 4.45 (in, 1H) ; 4.05 Cm, 2H); 3.80 Cs, 3H); 3.75 Cm, 2H); 3.59 Ct, 2H); 3.28 Ct, 2H); 3.06 (in, 2H); 2.90 Cm, 1H); 2.84 Cs, 3H); 2.80 Cs, 3H); 2.77 Cs, 3H); 2.56 Cs, 6H); 2.50 (in, 1H); 1.80 (in, 1H); 1.60 (in, 2H); 1.20 (in, 2H). Example 72 4-methoxy- N, 2,6-trimethyl-N- [2-[2-[4-(4-methyl- 1-pi perazinyl)1-piperidinyl]-2-oxoethoxy]ethyl]benzenesulphonam ide A suspension is prepared of 350 ing (1.06 mM) of acid obtained according to preparation III in 3 ml of DCM and 243 mg (1.27 mM) of EDGI (1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride) and 173 ing (1.27 mM) of HOAT, are added. The mixture is agitated for 30 mm at ambient temperature, and 232 ing (1.27 mM) of 1-methyl-4-(4-piperidinyl)piperazine are then added. The reaction mixture is agitated for 18 hours at ambient temperature and is then poured over 10 ml of water and extracted with DCM. The organic phase is washed with water, dried and concentrated under reduced pressure. The residue is purified by silica gel chromatography in eluting with the aid of a DCM/methanol mixture (90/10; v/v). 449 ing of the product sought after are thus obtained as a yellow oil (yield = 86 0/a). 'H NMR (300 MHz, CD3CN) 8: 6.74 Cs, 2H); 4.35 Cd, 1H); 4.01 (q, 2H); 3.81 Cs, 3H); 3.69 Cd, 1H); 3.56 Ct, 2H); 3.26 Ct, 2H); 2.89 Ct, 1H); 2.75 Cs, 3H); 2.58 Cs, 6H); 2.40 Cm, 1OH); 2.17 (5, 3H); 1.75 Cm, 2H) 1.27 Cm, 2H). Example 73 4-methoxy-N,2,6-trimethyl-N- [2-[2-[4-(4-methyl- 1-pi perazinyl)1-piperidinyl]-2-oxoethoxy]ethyl]benzenesulphonamide, fumarate 404 ing (0.814 mM) of the compound obtained according to Example 72 are dissolved in 5 ml of methanol and 95 ing (0.815 mM) of fumaric acid are added. The mixture is agitated for 10 mm and then concentrated under reduced pressure. The residue is taken up into 10 ml of water and the solution is freeze-dried. The salt sought after is thus obtained (474 ing) as a white powder (yield = 95 0/4 M.Pt. = 90 0C In operating analogously to Examples 72 and 73, starting with the acids and the derivatives of piperidine described above or known from the literature, the following compounds according to the invention are obtained: Example 74 4-methoxy-N, 2,6-trimethyl-N- [2-[2-[4-( 1-methyl-4-piperidinyl)- 1-piperidinylJ-2-oxoethoxy]ethyl]benzenesulphonamide, fumarate White solid (yield = 44 %). M.Pt. = 88-89 0C Example 75 N-cyclopropyl-4-methoxy-2,6-dimethyl-N- [2- [2-[4-(4-methyl- 1- piperazinyl)-1-piperidinyl]-2-oxoethoxy]ethyl]benzene-suiphonamide, difumarate White solid (yield = 76 0/a). M.Pt. = 148 0C Example 76 4-methoxy-N,2,6-trimethyl- N-[2- [2-[4- [2-(1- pyrrolidinyl)ethyl]1-piperidinyl]-2-oxoethoxy]ethyl ]benzenesu I phonamide, fu ma rate White solid (yield = 87 %). M.Pt. = 55 0C 'H NMR (300 MHz, CD3CN) 6: 8.50 Cm broad, 1H) ; 6.74 Cs, 2H); 4.38 (in, 1H) ; 4.10 Cd, 2H); 3.80 Cs, 3H); 3.75 (in, 1H); 3.57 (in, 4H) ; 3.27 Ct, 2H); 3.13 Cm, 2H); 2.95 Cm, 3H) ; 2.74 Cs, 3H); 2.57 Cs, 6H); 2.50 (in, 1H) ; 2.06 (in, 4H); 1.65 (in, 5H); 1.07 (in, 2H). Example 77 4-methoxy-N,2,6-trimethyl- N-[2-[2- [4- [4-( 1-methylethyl)- 1-p iperazinyl]- 1-piperidinyl]-2-oxoethoxy]ethyl]benzene-suiphonamide, fumarate White solid (yield = 92 %). M.Pt. = 145 0C Example 78 N-ethyl-4-methoxy-2,6-dimethyl-N-[2-[2-[4- [2-( 1- pyrrolidinyl)ethyl]- 1-piperidinyl]-2-oxoethoxy]ethyl]benzene- suiphonamide, fumarate White solid (yield = 50 0/a) M.Pt. = 50 0C Example 79 N-cyclopropyl-4-methoxy-2,6-dimethyl-N-[2-[2-[4-[2-(1-pyrrolidinyl)ethyl]- 1-piperidinyl]- 2-oxoethoxy]ethyl]benzene-suiphonamide, fumarate White solid (yield = 96 %). M.Pt. = 50 0C Examole 80 N'{2-[2-[4-[2-(hexahydro-4-methyl-1H-1,4-diazepin- 1-yI)ethyU- 1-piperidinyl ]-2-oxoethoxy]ethyl 1-4-methoxy- N,2,6-trimethyl- benzenesulphonamide, difumarate White solid (yield = 54 %). M.Pt. = 60 0C Example 81 4-methoxy-N,2,6-trimethyl-N-[2-[2-[4-[2-[methyl(1-methylethyl)amino]ethyl]- 1-piperidinyl]-2-oxoethoxy]ethyl ]-benzenesulphonamide, fumarate White solid (yield = 64 %). M.Pt. = 60 0C Example 82 4-methoxy- N, 2,6-trimethyl- N-[2- [2- [4-[methyl( 1-methyl-4-piperidinyl)amino]-1-piperidinyl]-2-oxoethoxy]ethyl]benzene-suiphonamide, fumarate White solid (yield = 66 %). M.Pt. = 72 0C Example 83 4-methoxy- N, 2,6-trimethyl- N-[2- [2- [4-[ 1-( 1-methylethyl)-4- piperidinyl]- 1-piperidinyl]-2-oxoethoxy]ethyl]benzene-suiphonamide, fumarate White solid (yield = 84 0/a). M.Pt. = 62-64 0C Examole 84 4-methoxy-N,2,6-trimethyl- N- [2- [2-(4-( 1-ethyl-4- piperidinyl)- 1- piperidinyl]-2-oxoethoxy]ethyl]benzenesulphonamide, fumarate Colourless oil (yield = 35 0/s). 'H NMR (300 MHz, DMSO) 8: 6.80 Cs, 2H) ; 6.51 Cs, 2H) ; 4.32 Cm, lH); 4.06 (q, 2H); 3.80 Cs, 3H) ; 3.67 (in, 1H); 3.53 Cm, 2H); 3.22 (in, 2H) 3.15 Cd, 2H) ; 2.86 Cm, 1H) ; 2.69 Cs, 3H) ; 2.61 (q, 2H) ; 2.53 Cs, 6H) 2.45 (in, 1H); 2.27 Ct, 2H) ; 1.66 (in, 4H) ; 1.30 (in, 3H) ; 1.07 Ct, 3H) 0.96 Cm, 3H). Examole 85 4-methoxy- N,2, 6-trimethyl- N- [2-[2- [4-( 1-cyclopropyl-4-piperidinyl)- 1-piperidinyl]-2-oxoethoxy]ethyl] benzenesuiphonamide, fumarate Colourless oil (yield = 63 %). 'H NMR (300 MHz, DMSO) 8: 6.80 Cs, 2H) ; 6.66 Cs, 2H) ; 4.34 Cm, 1H) 4.01 (q, 2H) ; 3.79 (s, 3H) ; 3.66 (in, 1H) ; 3.54 Ct, 2H) ; 3.21 Ct, 2H) ; 2.98 Cd, 2H); 2.82 (in, 1H) ; 2.69 Cs, 3H) ; 2.53 Cs, 6H) ; 2.43 Cm, 1H) 2.10 Ct, 2H); 1.60 (in, 5H) ; 1.23 (in, 1H) ; 1.03 Cm, 5H) ; 0.38 (in, 2H); 0.29 (in, 2H). Example 86 4-methoxy- N, 2,6-trimethyl- N-[2- [2- [4- [ 2-(4-morpholinyl)ethyl]- 1-piperidinyl]-2-oxoethoxy]ethyl]benzenesulphonamide, fumarate White solid (yield = 73 0/o). M.Pt. = 500C Example 87 4-methoxy-N,2,6-trimethyl-N-[2-[2-[4-[ 1,1-dimethyl-2-(1-azetidinyl)ethyl]- 1-piperidinyl]-2-oxoethoxy]ethyl ] benzenesuiphonamide, fumarate White solid (yield = 67 %). M.Pt. = 60-62 0C Example 88 N-ethyl-4-methoxy-2,6-dimethyl- N- [2-112-[4-( 1-methyt-4-piperidinyl)-1-piperidinyl]-2-oxoethoxy]ethyl]benzene-suiphonamide, fumarate White solid (yield = 67 ~/o). M.Pt. = 650C Example 89 N-[2-[2-[4-(hexahydro-4-methyl-1H-1,4-diazepin-1-yt)-1-piperidinyl]-2-oxoethoxy]ethyl]-4-methoxy- N,2,6-trimethyl-benzenesulphonamide, fumarate Yellow oil (yield = 61 0/a). 'H NMR (300 MHz, DMSO) 8: 6.80 Cs, 2H); 6.50 Cs, 2H); 4.36 Cm, 1H); 4.11 Cm, 2H); 3.80 Cs, 3H); 3.73 (in, 1H); 3.55 Ct, 2H); 3.24 (t, 2H); 2.87 Cm, 2H); 2.85 (in, 6H); 2.69 Cs, 3H); 2.67 (in, 1H); 2.53 Cs, 6H); 2.46 (5, 3H) ; 2.42 (in, 1H); 1.81 (in, 2H); 1.69 (in, 2H); 1.21 (in, 2H). Example 90 N-cyclopropyl-4-methoxy- 2,6-dimethyl- N- [2-[2-1i4-( 1- methyl-4-piperidinyl)- 1-piperidinyl]-2-oxoethoxy]ethyl]benzene-suiphonamide, fumarate White solid (yield = 60 0/a). M.Pt. = 800C Example 91 2,4-dichioro- N,3-dimethyl- N- [2-[2-[4-(1-methyl-4-pi peridinyl)-1- piperidi nyl]-2-oxoethoxy]ethyl]benzenesulphonamide, fumarate White solid (yield = 39 %). M.Pt. = 86-880C Example 92 4-methoxy-N,2,6-trimethyl- N-(2-[2-[4-[2-(1-azetidinyl)ethyl]-1-piperidinyl]-2-oxoethoxy]ethyl]benzenesulphonamide, fumarate White solid (yield = 40 0/a). 'H NMR (300 MHz, DMSO) 8: 6.80 Cs, 2H); 6.52 Cs, 2H) ; 4.28 (in, 1H); 4.05 (in, 2H); 3.80 Cs, 3H) ; 3.67 Cm, 1H); 3.57 Cm, 6H) ; 3.20 Ct, ZH) 2.85 (in, 1H) ; 2.78 Ct, 2H) ; 2.69 Cs, 3H) ; 2.53 Cs, 6H) ; 2.49 (in, 1H) ; 2.17 (quin, 2H) ; 1.59 (in, 2H) ; 1.50 (in, 1H) ; 1.30 (in, 2H) ; 0.93 Cm, 2H). Example 93 2,6-dichloro-4-methoxy- N-methyl- N- [2- [2- [4- [2- (dimethylamino)ethyl]-1-piperidinyl]-2-oxoethoxy]ethyl]- benzenesulphonamide, fumarate White solid (yield = 39 0/o). M.Pt. = 700C ExamDIe94 2,6-dichloro-4-methoxy-N-methyl- N-[2-[2-[4-( 1-methyl-4- piperidinyl)-1-piperidinyl]-2-oxoethoxy]ethyl]benzene-suiphonamide, fumarate White solid (yield = 70 %). M.Pt. = 670C Example 95 4-methoxy- N,2,6-trimethyl-N-[2-[2-[4-[(1-pyrrolidinyl)methyl]- 1-piperidinyl]-2-oxoethoxy]ethyl] benzenesulphonamide, fumarate Colourless oil (yield = 30 ~/o). 'H NMR (250 MHz, DMSO) 8: 6.80 (5, 2H); 6.54 (5, 2H); 4.29 (in, 1H); 4.15 Cm, 2H); 3.80 Cs, 3H); 3.63 Cm, 1H); 3.53 Ct, 2H); 3.22 Ct, 2H); 2.89 (in, 1H); 2.80 (in, 4H); 2.70 Cs, 3H); 2.56 (in, 1H); 2.53 Cs, 6H); 2.51 Cm, 2H); 1.81 Cm, 7H) ; 0.91 (in, 2H). Example 96 4-methoxy-N,2,6-trimethyl- N-[2-[2-[4-[(4-ethyl- 1-piperazinyl)methyl]- 1-piperidinyl ]-2-oxoethoxy]ethyl]benzene-suiphonamide, fumarate White solid (yield = 31 %). M.Pt. = 1200C Example 97 N..cyclopropyl-4-methoxy-2,6-dimethyl-N-[2-[2-[4-[(4-methyl- 1-piperazinyl)methyl]-1-piperidinyl]-2-oxoethoxy]ethyl]benzene-suiphonamide, difumarate White solid (yield = 44 %). M.Pt. = 1600C Example 98 N-ethyl-4- methoxy-2,6-d imethyl- N-[2- [2- [4-[(4-methyl- 1-piperazinyl)methyl]-1-piperidinyl]-2-oxoethoxy]ethyl]benzene-suiphonamide, difumarate White solid (yield = 49 0/a). M.Pt. = 980C Example 99 N-methyl-4-methoxy-2,6-dichloro- N-[2-[2-[4-[(4-methyl-1-pi perazinyl)methyl]- 1-piperidinyl ]-2-oxoethoxyJethyl]benzene-suiphonamide, difumarate White solid (yield = 50 %). M.Pt. = 1030C Example 100 4-methoxy-N,2,6-trimethyl-N-[2-[2-[4-[ 1, 1-dimethyl-2-(1-piperidinyl)ethyl]- 1-piperidinyl]-2-oxoethoxy]ethyl] benzenesuiphonamide, trifluoroacetate Colourless oil (yield = 47 %). 'H NMR (300 MHz, CD3CN) 6: 7.50 (in broad, 1H) ; 6.74 Cs, 2H) ; 4.49 (in, 1H) ; 4.01 (q, 2H) ; 3.81 Cs, 3H) ; 3.78 (in, 1H) ; 3.57 Ct, 2H) ; 3.43 (in, 2H); 3.28 Ct, 2H); 3.01 (in, 2H); 2.98 Cs, 2H); 2.90 (in, 1H); 2.74 Cs, 3H) ; 2.63 Cs, 6H) ; 2.45 (in, 1H); 1.85 Cm, 3H); 1.66 Cm, 3H) ; 1.51 (in, 2H) ; 1.19 (in, 3H); 1.00 Cs, 6H). Example 101 4-methoxy- N,2,6-trimethyl- N-[2-[2-[4-[ 1, 1-dimethyl-2-(1- pyrrolidinyl)ethyl]- 1-piperidinyl]-2-oxoethoxy]ethyl] benzenesuiphonamide, fumarate White solid (yield = 61 %). M.Pt. = 50 0C Example 102 N- [2-[2-[4-[2-(ethylmethylamino)ethyl ]- 1-piperidi nyl ]-2- oxoethoxy]ethyl]-4-methoxy- N,2,6-trimethylbenzene- suiphonamide, fumarate White solid (yield = 46 %). 1H NMR (300 MHz, DMSO) 6: 6.80 (5, 2H); 6.51 (5, 2H); 4.27 (in, 1H); 4.03 (q, 2H); 3.80 Cs, 3H); 3.55 Cm, 1H); 3.24 Ct, 2H); 3.22 Ct, 2H); 2.86 Cm, 1H); 2.70 Cs, 3H); 2.62 (in, 4H); 2.53 Cs, 6H); 2.48 (in, 1H); 2.46 (5, 3H); 1.66 (in, 2H); 1.52 (in, 1H); 1.45 (in, 2H); 1.38 Ct, 3H); 0.97 (in, 2H). Example 103 N-[2-[2-[4-[2-(diethylamino)ethyl]-1-piperidinyl]-2-oxoethoxy]ethyl]-4-methoxy- N, 2,6-trimethylbenzene-suiphonamide, fumarate White solid (yield = 52 0/a). M.Pt. = 600C Example 104 4-methoxy-N-(1-methylethyl)-2,6-dimethyl-N-[2-[2-[4-[2-( 1-pyrrolidinyl)ethyl]- 1-piperidinyl]-2-oxoethoxy]ethyl]benzene-suiphonamide, fumarate White solid (yield = 61 %). M.Pt. = 560C Example 105 4-methoxy-N,2,6-trimethyl-N-[2-[2-[4-[ 1, 1-dimethyl-2-(4-morpholinyl)ethyl]- 1-piperidinyl]-2-oxoethoxy]ethyl] benzenesuiphonamide, fumarate White paste (yield = 50 0/a). 'H NMR (300 MHz, DMSO) 6: 6.80 Cs, 2H); 6.62 Cs, 2H) ; 4.38 Cm, 1H); 4.04 (q, 2H); 3.79 Cs, 3H); 3.55 (in, 1H); 3.52 (in, 6H); 3.21 (in, 2H); 2.81 Cm, 1H); 2.70 Cs, 3H); 2.53 Cs, 6H); 2.49 (in, 4H); 2.47 Cm, 1H); 2.09 Cs, 2H); 1.60 (in, 2H); 1.43 Cm, 1H); 1.10 (in, 2H) ; 0.76 Cs, 6H). Example 106 N-[2-[2-[4-[2-(hexahydro-4-methyl- 1H-1,4-diazepin-1-yI)ethyl]- 1-piperidinylj-2-oxoethoxy]ethylj-4-methoxy- N, 2,6- trimethylbenzenesulphonamide, difumarate White solid (yield = 36 %). M.Pt. = 125 0C Example 107 N-[2-[2-[4-[(hexahyd ro-4-methyl- 1H- 1,4-diazepi n-1-yI)methyt]- 1-piperidinyl]-2-oxoethoxy]ethyl]-4-methoxy- N,2,6- trimethylbenzenesu Iphonamide, difuma rate White solid (yield = 31 %). M.Pt. = 100~102GC Example 108 4-methoxy-N-[2-[2-[4-[2-(1-methyl-4-piperidinyl)ethylJ-1-piperidinyl]-2-oxoethoxy]ethyl]- N,2,6-trimethylbenzenesulphonamide, fumarate White solid (yield = 240/a). M.Pt. = 700C In operating analogously to Example 70, starting with the acids and the derivatives of piperidine described above or known from the literature, the following compounds according to the invention are obtained Example 109 4-methoxy-N-[2-[2-[4-[2-(1-piperidinyl)ethyl]- 1-piperidinyl]-2-oxoethoxyjethyl]- N,2,6-trimethylbenzenesulphonamide, fumarate White solid (yield = 690/a). M.Pt. = 500C Example 110 4-methoxy-N-[2-[2-[4-[2-(1-pyrrolidinyl)ethyl]- 1-piperidinyl]-2-oxoethoxyjethyl]- N-methyl-2-trifluoromethyl-benzenesulphonamide, trifluoroacetate Colourless oil (yield = 99%). 'H NMR (300 MHz, CD3CN) 6: 8.20 (in broad, 1H); 7.95 Cd, 1H); 7.41 Cd, 1H); 7.25 (dd, 1H); 4.43 Cm, 1H); 4.10 (q, 2H) ; 3.91 Cs, 3H); 3.63 (in, 1H); 3.63 (in, 4H); 3.43 Ct, 2H); 3.13 (in, 2H); 2.96 (in, 2H); 2.90 Cs, 3H); 2.60 Ct, 1H); 2.06 Cm, 6H); 1.71 Cm, 4H); 1.60 Cm, 2H). Example 111 4-methoxy- N- [2-[2- [4- [2-( 1-methyl-4-pi perazinyl)-2-oxoethyl]- 1-piperidinyl]-2-oxoethoxy]ethyl]- N,2,6- trimethylbenzenesu Iphonamide, fumarate White solid Cyield = 33%). M.Pt. = 600C Example 112 4-methoxy-N,2,6-trimethyl-N-[2-[2-[4-[ 1,1-dimethyl-2- (diethylamino)ethyl]- 1-piperidinyl]-2-oxoethoxy]ethyl] benzenesuiphonamide, trifluoroacetate Colourless oil (yield = 26 %). 'H NMR (300 MHz, DMSO) 6 : 8.12 Cm broad, 1H); 6.81 Cs, 2H) ; 4.40 Cm, 1H); 4.09 (q, 2H); 3.80 Cs, 3H); 3.78 (in, 1H); 3.54 Ct, 2H); 3.24 Ct, 2H); 3.15 Cm, 4H); 2.97 Cd, 2H); 2.84 Ct, 1H); 2.70 Cs, 3H); 2.53 Cs, 6H); 2.41 Cm, 1H); 1.64 (in, 2H); 1.42 (in, 1H); 1.25 Cm, 2H); 1.22 Ct, 6H); 0.96 Cs, 6H). Example 113 4-methoxy- N,2,6-trimethyl- N- [2- [2- [4-(dimethylamino)methyl]- 1-piperidinyl]-2-oxoethoxy]ethyl]benzenesulphonamide, fumarate White solid (yield = 63 %). M.Pt. = 650C Example 114 4-methoxy-N,2,6-trimethyl-N- [2- [2- [4-[( 1-azetidinyl)methyl]-1- piperidinyl]-2-oxoethoxy]ethyl]benzenesul phonamide, fumarate White solid (yield = 60 %). M.Pt. = 750C Example 115 N,2,4,6-tetramethyl- N-[2-[2-[4-( 1-methyl-4-pi peridinyl)- 1-piperidinyl]-2-oxoethoxy]ethyl] benzenesu Iphonamide, trifluoroacetate Colourless oil Cyield = 97 %). 'H NMR (250 MHz, CD3CN) 6: 9.40 Cm broad, 1H); 6.97 Cs, 2H); 4.98 (in, 1H); 4.09 (q, 2H); 3.71 Cm, 1H); 3.57 Ct, 2H); 3.45 Cd, 2H); 3.28 Ct, 2H); 2.85 (in, 1H); 2.80 (in, 2H); 2.77 (5, 3H); 2.72 Cd, 3H); 2.56 Cs, 6H); 2.45 (in, 1H); 2.28 Cs, 3H) ; 1.92 Cm, 2H); 1.71 (in, 2H); 1.50 (in, 2H); 1.34 (in, 2H); 1.09 (in, 2H). Example 116 N-methyl- N-[2-[2-[4-( 1-methyl-4-piperidinyl)- 1-piperidinyl]-2-oxoethoxy]ethyl]-2-trifluoromethyl-benzenesulphonamide, trifluoroacetate Colourless oil (yield = 98 %). 'H NMR (300 MHz, CD3CN) 6: 8.50 (in broad, 1H); 7.97 (in, 2H); 7.77 (in, 2H) ; 4.48 (in, 1H); 4.13 (q, 2H); 3.80 Cm, 1H); 3.64 Cm, 2H); 3.49 Ct, 2H); 3.42 Cm, 2H); 2.96 Cs, 3H); 2.90 (in, 1H); 2.78 (in, 2H); 2.72 Cd, 3H); 2.50 (in, 1H); 1.93 Cm, 2H); 1.73 (in, 2H); 1.38 (in, 4H); 1.36 (in, 2H). Example 117 4-methoxy- N-methyl- N-[2- [2-[4-( 1-methyl-4-piperidi nyl)- 1- piperidinyl]-2-oxoethoxy]ethyl]-2-trifluoromethyl- benzenesulphonamide, trifluoroacetate Colourless oil (yield = 95 %). 'H NMR (300 MHz, CD3CN) 6: 8.41 Cm broad, 1H); 7.96 Cd, 1H); 7.40 Cd, 1H); 7.25 (dd, 1H); 4.45 (in, 1H); 4.10 Cq, 2H); 3.91 Cs, 3H); 3.80 (in, 1H); 3.61 Ct, 2H); 3.42 (in, 4H); 2.90 Cs, 3H); 2.89 (in, 1H); 2.79 Cm, 2H); 2.73 Cd, 3H); 2.50 (in, 1H); 1.92 Cm, 2H); 1.73 Cm, 2H); 1.37 (in, 4H); 1.07 Cm, 2H). Example 118 N,2,4,6-tetramethyl-N-[2-[2-[4-[2-(1-pyrrolidinyl)ethyl]- 1-p1 peridinyl]-2-oxoethoxy]ethyl] benzenesulphonamide, trifluoroacetate Colourless oil (yield = 99 %). 'H NMR (300 MHz, CD3CN) 6: 8.40 (in broad, 1H) ; 7.03 Cs, 2H) ; 4.37 Cm, 1H) ; 4.02 (q, 2H); 3.75 Cm, 1H) ; 3.58 (in, 4H) ; 3.31 Ct, 2H) ; 3.10 (in, 2H) ; 2.91 (in, 3H); 2.75 Cs, 3H) ; 2.56 Cs, 6H); 2.54 Cm, 1H) ; 2.29 Cs, 3H) ; 2.10 (in, 4H); 1.61 (in, 5H); 1.10 (in, 2H). Example 119 2, 6-dichloro-4-methoxy-N-methyl- N-[2-[2-[4-( 1-methyl-4-pi perazinyl)- 1-piperidinyl]-2-oxoethoxy]ethyl] benzenesuiphonamide, difumarate White solid (yield = 76 0/a). M.Pt. = 176 0C Example 120 4-methoxy- N,2,6-trimethyl- N- [2- [2-[4- [2-(dimethylamino)ethyl]- 1-piperidinyl]-2-oxoethoxy]-ethyl] benzenesulphonamide, fumarate A solution is prepared of 200 ing (0.6 mM) of acid obtained according to preparation III in 2 ml of chloroform and 0.2 ml of dimethylformamide and 0.12 ml of oxalyl chloride are added at ambient temperature. The mixture is agitated for 1 hour at ambient temperature and concentrated under reduced pressure. The residue is taken up into 3 ml of chloroform, and 103 ing (0.66 mM) of N,N-dimethyl-4-piperidineethanamine and 92 p1 of triethylamine are added, and agitation is carried out for 2 hours at ambient temperature. The reaction mixture is concentrated under reduced pressure and the residue is purified by silica gel chromatography in eluting with the aid of a dichloromethane/methanol/aqueous ammonia mixture (95/5/0.5; v/v/v). 247 ing of amide are obtained as an oil which is salified with fumaric acid according to the method applied in Example 73 to obtain the salt as a white solid (yield = 83 0/a). M.Pt. = 550C Example 121 4-methoxy- N,2,6-trimethyl-N- [2-[2-[4-(4-cyclopropyl- 1-piperazinyl)- 1-piperidinyl]-2-oxoethoxy]ethyl]benzene-suiphonamide, fumarate 2.2 g of tetrafluorophenol resin are placed in suspension in 10 ml of dimethylformamide and 40 ml of dichloromethane and 50 nig of 4-dimethylaminopyridine, 0.66 ml of diisopropylcarbodiimide and ig (3.1 mM) of acid obtained according to preparation III, are added. The mixture is agitated at ambient temperature for 16 hours, and then the resin is separated off by filtration and reallowed to react in 40 ml of dichloromethane with 0.5 g (2.39 mM) of 1-cyclopropyl-4-(4-piperidinyl)piperazine, for 2 hours at ambient temperature. The reaction mixture is filtered and the filtrate is concentrated under reduced pressure. The crude product obtained is purified by silica gel chromatography in eluting with the aid of a dichloromethane/methanol mixture (99/1; v/v). 700 ing of amide are obtained as an oil which is salified with fumaric acid according to the method applied in Example 73 to obtain the salt as a white solid (yield = 49 %). M.Pt. = 800C In operating analogously to Example 121, starting with the amines obtained according to preparations LXXXVIII and LXXIV, the following compounds according to the invention are obtained: Eample 122 4-methoxy-N,2,6-trimethyl- N- [2-[2-[4-[4-( 1, 1-d imethylethyl)- 1-p1 perazinyl]- 1-piperidinyl]-2-oxoethoxy]xethyl]benzene-suiphonamide, difumarate White solid (yield = 48 %) M.Pt. = 170 GC Example 123 4-methoxy-N,2,6-trimethyl- N- [2-112-[4-[(4-methyl- 1- piperazinyl)methyl ]- 1-piperidinyl ]-2-oxoethoxy]ethyl]benzene- suiphonamide, difumarate White solid (yield = 39 %) M.Pt. = 168 0C In operating analogously to Examples 70 and 73, starting with the amine obtained according to preparation CVII, the following compound according to the invention is obtained Example 124 4-methoxy-N,2,6-trimethyl- N- [2- [2-[4- [2-(4-methyl- 1-piperazinyl)ethyl]- 1-piperidinyl]- 2-oxoethoxy]ethyl]benzene-suiphonamide, difumarate White solid (yield = 59 %) M.Pt. = 178-1790C PREPARATION CXLVII 4-methoxy- N,2,6-trimethyl- N- [2- [2-[4-(3-hyd roxypropyl)- 1-piperidinyl]-2-oxoethoxy]ethyl]benzenesulphonamide In operating analogously to Example 72, starting with 3-(4- piperidinyl)propanol, the product sought after is obtained as a colourless oil (yield = 79 %). 'H NMR (300 MHz, DMSO) 6 : 6.80 Cs, 2H); 4.34 Ct, 1H); 4.28 (din, 1H); 4.03 (in, 2H); 3.79 Cs, 3H); 3.64 (din, 1H); 3.53 Ct, 2H); 3.37 Cd, 2H); 3.21 Ct, 2H); 2.86 Ct, 1H); 2.70 Cs, 3H); 2.53 Cs, 6H); 2.45 (in, 1H) 1.63 Cd, 2H); 1.40 (in, 3H); 1.19 (in, 2H); 0.93 (in, 2H). PREPARATION CXLVIII 4-methoxy- N,2,6-trimethyl- N-[2- [2- [4-[3-II(4- methylphenyl)sulphonyl]oxy]propyl]- 1-piperidinyl]-2-oxoethoxy]ethyl]-benzenesulphonam ide A solution is prepared of 6.8 g (14.9 mM) of the compound obtained according to preparation CXLVII in 50 ml of dichloromethane and, at ambient temperature, 3.4 ml (24.6 mM) of triethylamine, and then 4.68 g (24.6 mM) of tosyl chloride and 142 mg (1.5 mM) of trimethylamine hydrochloride, are added. The mixture is agitated for 4 hours under reflux of the solvent and then cooled and hydrolysed on 50 ml of water. The organic phase is washed with water, dried over magnesium sulphate and concentrated under reduced pressure. The residue is purified by silica gel chromatography in eluting with the aid of an ethyl acetate/toluene mixture (8/2; v/v). 5.6 g of the compound sought after are obtained as a colourless oil (yield = 62 %). 'H NMR (300 MHz, DMSO) 6: 7.79 (dd, 2H) ; 7.48 Cd, 2H); 6.80 Cs, 2H); 4.26 Cm, 1H) ; 4.00 (in,, 3H); 3.79 Cs, 3H) ; 3.62 Ct, 2H); 3.51 (in, 2H) 3.23 (in, 2H); 2.85 (in, 1H); 2.70 Cs, 3H) ; 2.53 (5, 6H) ; 2.45 (in, 1H) 2.41 (s, 3H); 1.55 (in, 3H); 1.29 Cm, 2H); 1.13 (in, 2H) ; 0.89 Cm, 2H). Example 125 4-methoxy-N,2,6-trimethyl- N-[2-[2- [4-[3-(4-morpholinyl)-propyl]- 1-piperidinyl]-2-oxoethoxy]ethyl]benzenesulphonamide A solution is prepared of 400 mg (0.65 mM) of the compound obtained according to preparation CXLVIII in 8 ml of dimethylformamide and, at ambient temperature, 90 nig (0.65 mM) of potassium carbonate, and then 95 p1 (1 mM) of morpholine, are added. The mixture is agitated for 16 hours at 600C and then cooled, hydrolysed on 20 ml of water and extracted with ethyl acetate. The organic phase is washed with water, dried over magnesium sulphate and concentrated under reduced pressure. The residue is purified by silica gel chromatography in eluting with the aid of a dichloromethane/methanol mixture (98/2; v/v). 150 mg of the compound sought after are obtained as a colourless oil (yield = 44 0A,). 'H NMR (300 MHz, DMSO) 6: 6.80 Cs, 2H); 4.27 (in, 1H); 4.05 (q, 2H); 3.79 Cs, 3H); 3.70 (in, 1H); 3.54 (in, 6H); 3.21 Ct, 2H); 2.85 (in, 1H); 2.70 Cs, 3H); 2.53 (5, 6K); 2.42 (in, 1H); 2.31 (in, 4H); 2.22 Ct, 2H); 1.65 Cm, 2H); 1.41 (in, 3H); 1.36 (in, 2H); 0.96 (in, 2H). Example 126 4-methoxy-N,2,6-trimethyl-N-[2-[2-[4-[3-(4-morpholinyl)-propyl]-1-piperidinyl]-2-oxoethoxy]ethyl]benzenesulphonamide, fumarate In operating analogously to Example 73, starting with the compound obtained according to Example 125, the product sought after is obtained as a white solid (yield = 99 0/a). M.Pt. = 500C In operating analogously to Examples 125 and 126, starting with various amines, the following compounds according to the invention are obtained: Example 127 4-methoxy-N,2,6-trimethyl- N-[2-[2-[4-[3-(1-pyrrolidinyl)propyl]- 1-piperidinyl ]-2-oxoethoxy]ethyl]-benzenesulphonamide Colourless oil (yield = 53%). 'H NMR (300 MHz, DMSO) 6: 6.80 Cs, 2H); 4.30 Cm, 1K); 4.06 (q, 2K); 3.80 Cs, 3K); 3.68 Cm, 1H); 3.53 Ct, 2K); 3.20 Ct, 2K); 2.90 (in, 1K); 2.71 Cs, 3H); 2.61 Cm, 6H); 2.53 Cs, 6H); 2.48 (in, 1K); 1.75 Cs, 4H); 1.62 (in, 2K); 1.48 Cm, 2H); 1.42 Cm, 1H); 1.21 (in, 2H); 0.92 Cm, 2H). Example 128 4-methoxy-N,2,6-trimethyl-N-[2-[2-[4-[3-(1-pyrrolidinyl)propyl]- 1-piperidinyl]-2-oxoethoxy]ethyl]benzene-suiphonamide, fumarate White solid (yield = 92%). M.Pt. = 500C Examnle 129 4-methoxy-N,2,6-trimethyl- N- [2- [2- [4- [3-(hexahyd ro-4-methyl- 1H- 1,4-diazepin-1-yI)propyl]- 1-piperidinyl]-2-oxoethoxy]ethyl]benzene-sulphonamide Colourless oil (yield = 27%). 'H NMR (300 MHz, DMSO) 6: 6.80 Cs, 2K); 4.29 Cm, 1H); 4.05 (q, 2H); 3.79 (5, 3H); 3.65 (in, 1H); 3.50 Ct, 2H); 3.23 Ct, 2H); 2.85 (in, 1K); 2.69 Cs, 3K); 2.57 Cm, 8H); 2.46 Ct, 2K); 2.34 Cs, 3H); 1.65 (in, 4H); 1.37 (in, 3K); 1.17 (in, 2H) ; 0.95 Cm, 2K). Example 130 4-methoxy- N,2,6-trimethyl- N- [2- [2- [4-[3-(hexahydro-4-methyt- 1H- 1,4-diazepin-1-yI)propyl]-1-piperidinyl]-2- oxoethoxy]ethyl]benzene-sulphonamide, difumarate White solid (yield = 4l0/a). M.Pt. = 1740C Example 131 4-methoxy-N,2,6-trimethyl- N-[2- [2- [4-[3-(4-methyl- 1-piperazinyl)propyl]- 1-piperidinyl]-2-oxoethoxy]ethyl]benzene-suiphonamide Colourless oil (yield = 43%). 'H NMR (300 MHz, DMSO) 6: 6.80 Cs, 2H); 4.27 (in, 1H) ; 4.03 (q, 2K); 3.79 Cs, 3K); 3.65 Cm, 1K) ; 3.52 Ct, 2K) ; 3.23 Ct, 2K) ; 2.85 (in, 1K) ; 2.69 Cs, 3K); 2.53 Cs, 6K) ; 2.48 Cm, 1K) ; 2.29 Cm, BK) ; 2.23 Ct, 2K) 2.12 Cs, 3K); 1.63 Cm, 2K); 1.38 Cm, 3K); 1.17 (in, 2K) ; 0.95 Cm, 2K). Example 132 4-methoxy- N,2,6-trimethyl- N-[2- [2- [4- [3-(4-methyl- 1-piperazinyl)propyl]- 1- piperidinyl]-2-oxoethoxy]ethyl] benzenesuiphonamide, difumarate White solid (yield = 89%). M.Pt. = 1740C Example 133 4-methoxy-N,2,6-trimethyl-N-[2-[2- [4-[3-(1-azetidinyl)propyl]- 1-piperidinyl]-2-oxoethoxylethyl]benzenesulphonamide Colourless oil (yield = 23%). 'H NMR (300 MHz, DMSO) 6: 6.80 Cs, 2H); 4.26 (in, 1K); 4.02 (q, 2K); 3.80 Cs, 3K); 3.68 Cm, 1K); 3.54 Ct, 2K); 3.21 Ct, 2K); 3.03 Ct, 4K); 2.85 (in, 1K); 2.70 Cs, 3K); 2.53 Cs, 6K); 2.48 (in, 2K); 2.47 (in, 1H); 2.25 Ct, 2K); 1.91 (quin, 2K); 1.60 Cm, 2K); 1.40 Cm, 1K); 1.18 (in, 4K) ; 0.89 Cm, 2K). Example 134 4-methoxy-N,2,6-trimethyl- N-[2-[2-[4-[3-(1-azetidinyl)propyl]- 1-piperidinylj-2-oxoethoxy]ethylJbenzenesulphonamide, fuma rate White solid (yield = 93%). M.Pt. = 650C Example 135 4-methoxy-N,2,6-trimethyl-N-[2-[2-[4-[3-(dimethylamino)-propyl]-1-piperidinyl]-2-oxoethoxy]ethyl]benzenesulphonamide Colourless oil (yield = 23%). 'K NMR (250 MHz, DMSO) 6: 6.80 Cs, 2K) ; 4.30 (in, 1K) ; 4.02 (q, 2K); 3.79 (5, 3K) ; 3.65 Cm, 1K) ; 3.52 Ct, 2K) ; 3.21 Ct, 2K) ; 2.85 Cm, 1K) ; 2.70 (s, 3K) ; 2.53 Cs, 6K) ; 2.44 (in, 1K) ; 2.14 Ct, 2K) ; 2.09 Cs, 6K) ; 1.60 (in, 2K); 1.38 Cm, 3K); 1.17 Cm, 2K); 0.91 Cm, 2K). Example 136 4-methoxy-N,2,6-trimethyl- N-[2- [2-[4- [3-(dimethyla mino)propyl]- 1-piperidinyl]-2-oxoethoxy]ethyl]-benzenesulphonamide, fumarate White solid (yield = 990/a). M.Pt. = 55GC PREPARATION CIL 1'-[[2-[[(4-methoxy-2,6-dimethyiphenyl)suiphonyl]methyl- amino]ethoxy]acetyl] [4,4'-bipiperidine]- 1-carboxytic acid, 1,1-dimethylethyl ester In operating analogously to Example 72, starting with the compound obtained according to preparation LXXXIX, the product sought after is obtained as a colourless oil (yield = 88 0/o). 'H NMR (250 MHz, DMSO) 8: 6.80 Cs, 2H); 4.39 Cm, 1K); 3.98 Cm, 4K); 3.79 Cs, 3H); 3.70 Cm, 1K); 3.53 Ct, 2K); 3.20 Ct, 2K); 2.85 Cm, 1K); 2.69 Cs, 3K); 2.61 (in, 2K); 2.53 Cs, 6K); 2.43 (in, 1K); 1.62 Cm, 4K); 1.38 Cs, 9H); 1.23 (in, 2K); 1.01 Cm, 4K). Example 137 N-[2-(2-[4,4'-bipiperidin]- 1-yI-2-oxoethoxy)ethyl]-4-methoxy-N,2,6-trimethyl-benzenesulphonam ide, trifluoroacetate In operating analogously to preparation CXXI, starting with the compound obtained according to preparation CIL, the product sought after is obtained as a white foam (yield = 99 0/a). 'H NMR (250 MHz, CD3CN) 8: 7.00 (in broad, 1K); 6.74 Cs, 2K); 4.48 (in, 1K) ; 4.05 (q, 2K); 3.80 Cs, 3K) ; 3.75 (in, 1K) ; 3.57 Ct, 2K); 3.35 (in, 2K) ; 3.30 Ct, 2K), 2.92 (in, 3K) ; 2.74 Cs, 3K); 2.57 Cs, 6K) ; 2.48 (in, 1K) ; 1.89 (in, 2K); 1.71 (in, 2K) ; 1.43 (in, 4K); 1.10 (in, 2K). PREPARATION CL [2-[1-[[2-[[(4-methoxy-2,6-dimethylphenyl)sulphonyl]methyl-amino]ethoxy]acetyl]-4-piperidinyl]ethyl]methyl-carbamic acid, 1, 1-dimethylethyl ester In operating analogously to Example 72, starting with the compound obtained according to preparation CXIV, the product sought after is obtained as a colourless oil (yield = 82 0/a). 'H NMR (250 MHz, DMSO) 6: 6.80 Cs, 2H); 4.32 (in, 1H); 4.04 (q, 2K); 3.80 (s, 3K); 3.69 Cm, 1H); 3.56 Ct, 2H); 3.21 Ct, 2K); 3.19 Cm, 2H) 2.85 Cm, 1K); 2.74 (5, 3H); 2.70 Cs, 3K); 2.53 Cs, 6K); 2.46 (in, 1K) 1.65 Cm, 2K); 1.38 Cs, 9K); 1.34 (in, 3K); 1.01 Cm, 2K). Example 138 4-methoxy-N,2,6-trimethyl-N-[2- [2- [4-[2-(methylam ino)ethyl]1-piperidinyl]-2-oxoethoxy]ethylJbenzenesulphonam ide In operating analogously to preparation XXIX, starting with the compound obtained according to preparation CL, the product sought after is obtained as a colourless oil (yield = 99 0/c,). 'H NMR (250 MHz, DMSO) 8: 6.80 Cs, 2K); 4.25 Cm, 1K) ; 4.05 (q, 2K); 3.80 (5, 3K) ; 3.65 (in, 1K) ; 3.55 Ct, 2K) ; 3.19 Ct, 2K) ; 2.85 (in, 1K) 2.70 Cs, 3K) ; 2.51 Cs, 6K) ; 2.48 (in, 3K) ; 2.24 Cs, 3K) ; 1.59 Cm, 2K) ; 1.52 Cm, 1K); 1.34 (in, 2K) ; 0.92 Cm, 2K). Example 139 4-methoxy-N,2,6-trimethyl-N-[2-[2- [4- [2-(methylam ino)ethyt]1-piperidinyl]-2-oxoethoxy]ethyl]benzenesulphonam ide, fu ma rate In operating analogously to Example 73, starting with the compound obtained according to Example 138, the product sought after is obtained as a white solid (yield = 99 0/a). M.Pt. = 500C PREPARATION CLI [1-[[ 2-[ [(4-methoxy-2,6-dimethylphenyl)sulphonyl]methyl-amino]ethoxy]acetyl]-4-piperidinyl]carbamic acid, 1,1-dimethylethyl ester In operating analogously to Example 72, starting with t-butyl (4-piperidinyl)carbamate, the product sought after is obtained as a colourless oil (yield = 66 0/a). 'H NMR (250 MHz, DMSO) 8: 6.80 Cs, 2K); 4.07 Cm, 1H) ; 4.04 (in, 2H); 3.80 Cs, 3K) ; 3.52 Cm, 4K) ; 3.22 Ct, 2K) ; 2.95 Cm, 1K) ; 2.70 (5, 3H) 2.67 (in, 1K); 2.53 Cs, 6K); 1.72 (in, 2K); 1.38 (5, 9K); 1.26 Cm, 2K). Examole 140 N-[2-[2-(4-amino- 1-piperidinyl)-2-oxoethoxy]ethyl]-4-methoxy-N,2,6-trimethyl- benzenesu Iphonamide In operating analogously to preparation XXIX, starting with the compound obtained according to preparation CL, the product sought after is obtained as a yellow oil (yield = 86 0/a). 'H NMR (300 MHz, DMSO) 8: 6.80 Cs, 2K); 4.13 Cm, 1K) ; 4.05 (in, 2K); 3.80 Cs, 3K) ; 3.60 (in, 1K) ; 3.55 Ct, 2K) ; 3.46 Cm broad, 2K) ; 3.22 Ct, 2K) ; 2.89 Cm, 2K); 2.70 (5, 3K); 2.67 Cm, 1K) ; 2.53 Cs, 6K) ; 1.74 (in, 2K); 1.51 Cm, 2K). Example 141 4-methoxy-N,2,6-trimethyl- N-[2-[2-[4-[(8-methyl-8-azabicyclo[3.2..1]oct-3-yI)amino]-1-piperidinyl]-2-oxoethoxy]ethyl]benzenesulphonamide In operating analogously to preparation LXXI, starting with the compound obtained according to Example 140, the product sought after is obtained as a colourless oil (yield = 40 0/a). 'H NMR (250 MHz, DMSO) 8: 6.80 Cs, 2K); 4.13 (in, 1K) ; 4.05 Cm, 2K); 3.79 Cs, 3K) ; 3.65 (in, 1K) ; 3.50 Ct, 2K) ; 3.22 Ct, 2K) ; 2.91 (in, 4K) 2.70 Cs, 3K) ; 2.60 (in, 2K) ; 2.51 Cs, 6K) ; 1.85 (in, 8K); 1.45 (in, 2K) ; 0.96 Cm, 2K). Example 142 4-methoxy- N,2,6-trimethyl- N-[2- [2- [4- [(8-methyl-B- azabicyclo[3. 2. 1]oct-3-yI)amino]-1-piperidinyl]-2-oxoethoxy]-ethyl]benzenesulphonamide, bis(trifluoroacetate) A mixture of 140 ing (0.26 mM) of the compound obtained according to Example 141 is agitated until dissolution in 4 ml of a solution of 60/a trifluoroacetic acid in water. The solution is frozen and freeze-dried and 200 ing of the product sought after are thus obtained as a white solid (quantitative yield). M.Pt. = 70 0C In operating analogously to preparation CLI and to Examples 140 to 142, starting with t-butyl methylC4-pi peridi nyl)carbamate, the following compounds are obtained: PREPARATION CLII [1-[[2-[[(4-methoxy-2,6-dimethylphenyl)sulphonyl]methyl-amino]ethoxy]acetyl]-4-piperidinyl]methylcarbam ic acid, 1,1-dimethylethyl ester Colourless oil (yield = 49 0/a). 'H NMR (300 MHz, DMSO) 8: 6.80 (5, 2H); 4.38 (in, 1K); 4.32 (in, 1K); 4.07 Cm, 2K); 4.01 Cm, 1K); 3.80 (5, 3K); 3.74 (in, 1K); 3.54 (in, 2K); 3.23 Ct, 2K); 2.93 (in, 1K); 2.70 Cs, 3K); 2.63 Cs, 3K); 2.53 Cs, 6K); 1.53 (in, 4K); 1.39 (5, 9K). Example 143 4-methoxy-N,2,6-trimethyl- N- [2-[2-[4-(methylam mo)- 1- piperidinyl]-2-oxoethoxy]ethyl]- benzenesulphonamide Colourless oil (yield = 99 0/a). 'H NMR (250 MHz, DMSO) 8: 6.80 Cs, 2H); 4.18 Cm, 1H); 4.08 Cm, 2H); 3.80 Cs, 3H); 3.68 (in, 1K); 3.54 Ct, 2K); 3.23 Ct, 2H) ; 2.95 Cm, 1H); 2.85 (in, 1H); 2.70 Cs, 3H); 2.67 (in, 1H); 2.53 Cs, 6K); 2.42 Cs, 3K); 1.85 (in, 2K); 1.25 (in, 2K). Example 144 4-methoxy- N,2,6-trimethyl-N- (2- [2-[4-[methyl(8-methyl-8-azabicyclo[3.2. 1]oct-3-yI)amino]- 1-piperidinyl]-2-oxoethoxy]ethyl]benzenesulphonam,de Colourless oil (yield = 34 %). 'K NMR (300 MHz, DMSO) 8: 6.80 Cs, 2K) ; 4.30 Cm, 1K) ; 4.10 (q, 2K); 3.80 Cs, 3H) ; 3.67 (in, 1K) ; 3.52 Ct, 2K) ; 3.30 (in, 2K) ; 3.21 Ct, 2K) 2.88 (in, 1K) ; 2.75 Cm, 2K) ; 2.70 Cs, 3K); 2.53 Cs, 6H) ; 2.49 (in, 1K) 2.14 Cs, 3K); 2.05 Cs, 3K); 1.89 Cm, 2K); 1.45 Cm, 8K); 1.23 (in, 2K). ExamDte 145 4-methoxy- N, 2,6-trimethyl- N-[2- [2- [4- [methyl(8-methyt-8-azabicyclo[3. 2.1]oct-3-yI)amino]- 1-piperidinyl]-2-oxoethoxyjethyl] benzenesul phonam ide, bis(trifluoroacetate) Colourless oil (yield = 99 %). 'K NMR (250 MHz, CD3CN) 8: 6.75 (5, 2K); 4.62 Cm, 1K); 4.06 (in, 2K); 3.97 (in, 2K); 3.92 Cm, 1K) ; 3.81 (5, 3K); 3.65 Cm, 1K) ; 3.59 (in, 3K); 3.30 Ct, 2K); 3.05 (in, 1K); 2.74 Cs, 3K); 2.71 (d, 3K); 2.63 Cs, 3K); 2.70-2.55 (in, 3K); 2.53 Cs, 6K); 2.27 Cm, 4K); 1.97 (in, 4K); 1.62 (in, 2K). PREPARATION CLIII 4-[( 1-[( 1, 1-dimethylethoxy)ca rbonyl]-4-piperidinyl]methyl]-1-piperazinecarboxylic acid, phenylmethyl ester In operating analogously to preparation LXXI, starting with the t-butyl ester of 4-formyl-1-piperidinecarboxylic acid and with the benzyl ester of 1-piperazinecarboxylic acid, the product sought after is obtained as a colourless oil (yield = 26 0/a). 'K NMR (300 MHz, DMSO) 6: 7.31 Cm, 5K); 5.11 Cs, 2K) ; 3.90 Cm, 2K) 3.64 Cm, 4K); 2.75 (in, 8K); 1.89 Cm, 1K) ; 1.70 Cm, 2K) ; 1.39 Cs, 9K) 1.04 (in, 2K). PREPARATION CLIV 4-(4-piperidinylmethyl)- 1-piperazinecarboxylic acid, phenylmethyl ester In operating analogously to preparation XXIX, starting with the compound obtained according to preparation CLIII, the product sought after is obtained as a colourless oil (yield = 83 0/a). 'H NMR (250 MHz, DMSO) 8: 7.35 Cm, 5K); 5.00 Cs, 2K); 3.35 Cm, 4K); 2.95 (in, 2K); 2.46 Cm, 2K); 2.30 (in, 4K); 2.11 (in, 2K); 1.65 (in, 3K); 0.98 (in, 2K). PREPARATION CLV 4-[[ 1-[[2-E[(4-methoxy-2,6-dimethylphenyl)sul phonyl]methylamino]ethoxy]acetyl]-4- piperidinyl]methyl]- 1-piperazinecarboxylic acid, phenylmethyl ester In operating analogously to Example 72, starting with the compound obtained according to preparation CLIV, the product sought after is obtained as a colourless oil (yield = 70 %). 'H NMR (250 MHz, DMSO) 8: 7.35 Cm, 5K) ; 6.80 Cs, 2K) ; 5.07 Cs, 2K) 4.25 (in, 1K); 4.05 Cm, 2K) ; 3.79 Cs, 3K); 3.68 (in, 1K) ; 3.53 Ct, 2K) ; 3.30 (in, 4K) ; 3.21 Ct, 2K) ; 2.88 (in, 1K) ; 2.69 Cs, 3K) ; 2.53 Cs, 6K) ; 2.51 (in, 1K); 2.31 Cm, 4K); 2.27 (in, 2K); 1.70 Cm, 3K) ; 0.95 (in, 2K). Example 146 4-methoxy- N,2,6-trimethyl- N- [2-[2-oxo-2-[4-( 1-piperazinyl- methyl)- 1-piperidinyl]ethoxy]ethyl]benzenesulphonamide In operating analogously to preparation XXXV, starting with the compound obtained according to preparation CLV, the product sought after is obtained as a colourless oil (yield = 93 0/~4 'K NMR (300 MHz, DMSO) 8: 6.80 Cs, 2K) ; 4.25 (in, 1K) ; 4.05 (q, 2K) 3.79 Cs, 3K) ; 3.54 (in, 1K) ; 3.51 Ct, 2K) ; 3.23 Ct, 2K) ; 2.87 Cm, 1K) 2.70 Cs, 3K); 2.66 (in, 4K) ; 2.53 Cs, 6K); 2.50 Cm, 1K) ; 2.46 (in, 4K) 2.05 Cd, 2K); 1.74 Cm, 3K) ; 0.98 Cm, 2K). Example 147 4-methoxy-N,2,6-trimethyl- N- [2-[2-oxo-2-[4-( 1-piperazinyl-methyl)- 1-piperidinyl]ethoxy]ethyl]benzenesulphonamide, fuma rate In operating analogously to Example 73, starting with the compound obtained according to Example 146, the product sought after is obtained as a white solid (yield = 93 oA,). M.Pt. = 85-87 GC PREPARATION CLVI 1-[[2-[[(4-methoxy-2,6-dimethylphenyl)sulphonyl]methylamino] ethoxy]acetyl]- 4-piperidinecarboxylic acid, ethyl ester In operating analogously to Example 70, starting with the ethyl ester of 4-piperidinecarboxylic acid, the product sought after is obtained as a colourless oil (yield = 89 %). 'K NMR (250 MHz, DMSO) 8: 6.80 Cs, 2K); 4.17 Cm, 5K); 3.80 Cs, 3K); 3.65 (in, 1K); 3.53 Ct, 2K); 3.29 (5, 3K); 3.21 Ct, 2K); 2.99 Cm, 1K); 2.72 (in, 1K); 2.70 Cs, 3K); 2.58 Cm, 1K); 2.53 (5, 6K); 1.83 Cm, 2K); 1.44 (in, 2K); 1.20 Ct, 3K). PREPARATION CLVII 1-[[2-[[(4-methoxy-2,6-dimethylphenyl)sulphonyl ]methylamino] ethoxyjacetyl]- 4-piperidinecarboxylic acid A solution is prepared of 2.3 g (4.89 mM) of ester obtained according to preparation CLVI in 40 ml of tetrahydrofuran and a solution of 246 ing (5.8 mM) of lithia in 3 ml of water is added. The mixture is agitated at ambient temperature overnight and then concentrated under reduced pressure. The residue is taken up into 25 ml of water, acidified up to pH 2 with an N solution of hydrochloric acid and extracted with ethyl acetate. The organic phase is dried over magnesium sulphate and concentrated under reduced pressure. The crude product is purified by silica gel chromatography in eluting with the aid of a dichloromethane/methanol mixture (95/5; v/v). 1.6 g of the compound sought after are obtained as a colourless oil (yield = 74 %). 'K NMR (300 MHz, DMSO) 8: 6.80 Cs, 2K); 4.10 Cm, 1K); 4.06 Cm, 2K); 3.79 (5, 3K); 3.55 Cm, 1K); 3.53 Ct, 2K); 3.23 Ct, 2K); 2.98 (in, 1K); 2.74 (in, 1K); 2.70 Cs, 3K); 2.53 Cs, 3K); 2.50 Cs, 6K); 2.43 (in, 1K); 1.85 (in, 2K); 1.40 (in, 2K). Example 148 4-methoxy-N,2,6-trimethyl- N-[2- [2-oxo-2-[4-[1-oxo-2-(4-methyl-1-piperazinyl)ethyl]-1-piperidinyljethoxy]- ethyl] benzenesul phonam ide, bis(trifiuoroacetate) A solution is prepared of 0.65g (1.47 mM) of acid obtained according to preparation CLVII in 20 ml of dichloromethane and 0.25 ml of oxalyl chloride are added. The mixture is agitated for 2 hours at ambient temperature and is concentrated under reduced pressure. The yellow oil obtained is taken up into 8 ml of tetrahydrofuran and 8 ml of acetonitrile and, at 0 0C, 0.74 ml (1.47 mM) of a 2M solution of trimethylsilyldiazomethane in hexane are added. The mixture is agitated 1 hour at ambient temperature and then concentrated under reduced pressure. The residue is taken up into solution in 10 ml of chloroform and is added dropwise to a solution of 147 ing (1.47 mM) of Nmethylpiperazine in 10 ml of chloroform, in the presence of 10 ing of chlorocyclopentadienylbis(triphenylphosphine)ruthenium(II), at 600C. The reaction mixture is agitated at 600C for 30 mm and then concentrated under reduced pressure. The crude product is purified by silica gel chromatography in eluting with the aid of a dichloromethane/methanol mixture (85/15; v/v). The oily product obtained is salified directly trifluoroacetic acid in applying the procedure described in Example 142. 0.167 g of the compound sought after are obtained as a colourless oil (yield = 21 0/a). 'K NMR (300 MHz, CD3CN) 8: 6.75 Cs, 2K) ; 4.35 Cm, 1K) ; 4.04 (in, 2K) 3.83 Cs, 3K); 3.81 Cs, 2K); 3.70 (in, 1K) ; 3.58 Ct, 2K); 3.38 Cm, 4K); 3.30 Ct, 2K) ; 3.22 (in, 4K) ; 2.95 Cm, 1K) ; 2.81 (5, 3K) ; 2.74 Cs, 3K) 2.69 Cm, 2K); 2.56 Cs, 6K); 1.80 (in, 2K); 1.45 (in, 2K). Example 149 4-methoxy- iV,2,6-trimethyl- N-[2- [2-[4-( 1-methyl-4-piperidinyl)]- 1-piperazinyl]-2-oxoethoxy]ethyl]benzenesulphonamide A solution is prepared of 7 g (21 mM) of acid obtained according to preparation III in 50 ml of chloroform and 0.1 ml of dimethylformamide and, at ambient temperature, a solution of 3.7 ml (42 mM) of oxalyl chloride in 8 ml of chloroform, is added dropwise. The reaction mixture is agitated for 3 hours at ambient temperature and concentrated under reduced pressure. The residue from evaporation is taken up into 20 ml of chloroform and is added slowly, at 00C, to a solution of 4.04 g (22 mM) of 1-(1-methyl-4-piperidinyl)piperazine and 8.7 ml of triethylamine in 40 ml of chloroform. The reaction mixture is agitated for 1 hour at 00C and then poured over 60 ml of iced water. The mixture obtained is extracted with 100 ml of chloroform and the organic phase is washed with a solution of sodium bicarbonate, and then with water, dried over magnesium sulphate and concentrated under reduced pressure. The product sought after is thus obtained as an oil (yield = 81.70/a) which is used, without other purification, to obtain a salt with an acid. Example 150 4-methoxy- N,2,6-trimethyl- N-[2-[2-[4-( 1-methyl-4-piperidinyl)]- 1-piperazinyl]-2-oxoethoxy]ethyl]benzenesulphonamide, dihydrochioride A solution is prepared of 6 g (12 mM) of the compound obtained according to Example 149 in 100 ml of ethanol heated to around 650C. 3.2 ml (36 mM) of concentrated hydrochloric acid are then added, at around 600C. A precipitate forms rapidly. After 2 hours under agitation at ambient temperature, the suspension is cooled to 00C and filtered on a sinter. The solid isolated is washed with 10 ml of cold ethanol and then with 15 ml of ethyl ether and dried under reduced pressure. 5.2 g of the salt sought after are thus obtained as a white solid (yield = 75 %). M.Pt. 2500C Example 151 4-methoxy- N,2,6-trimethyl-N-[2- [2-[4-( 1-methyl-4-piperidinyl)]- 1-piperazinylJ-2-oxoethoxy]ethyl]benzenesulphonamide, difumarate In operating analogously to Example 150, with 2.5 equivalents of fumaric acid, the product sought after is obtained as a white solid (yield = 76 0/a). M.Pt. = 185 0C Table (Table Removed) In the above table, trifluoroacetic acid, Is means a single bond, TFA means that the compound is in the form of a salt with F means that the compound is in the form of a salt with fumaric acid. HCI means that the compound is in the form of a salt with hydrochloric acid. Biological activity The compounds of the present invention were evaluated for their analgesic property using the formalin-induced pain response test in mice (Shibata, M., Ohkubo, T., Takahashi, K. & P.. Inoki. Modified formalin test: characteristic biphasic pain response. Pain, 38, 347-352). To summarize, formalin (0.92 0/a in physiological saline) is injected into the hind paw and the period of paw licking, which represents pain intensity, is recorded from 0 to 5 mm (1~ phase) and from 15 to 30 mm (2nd phase) after the injection. According to this test, the percentage inhibition of the second paw licking phase induced by formalin is 43% for the compound of example 4 administered via the oral route at a dose of 3 mg/kg and 40 0/~ for the compound of example 6 administered via the oral route at a dose of 1 mg/kg. These results demonstrate a substantial lowering of pain response after administering the compounds. Subsequent to the results of the preceding test, the compounds of the invention were subjected to a test intended to demonstrate their mode of action and involving the B, receptor of bradykinin. This test uses the human umbilical vein and is conducted as per the following protocol: Human umbilical cords 15-25 cm long are recovered just after delivery and are immediately placed in a flask containing a Krebs solution of composition (in mM): 119 NaCI 119, 4.7 KCI, 1.18 KK2PO4, 1.17 MgSO4, 25 NaKCO3, 2.5 CaCI2, 5.5 Glucose, 0.026 EDTA then stored at 40C. The cord is dissected in Krebs solution to release the umbilical vein. The vein is cleansed of all adhering tissue and cut into small rings 3-4 mm in width. The endothelium is carefully removed by inserting a fine n0 1 catheter, made slightly abrasive, into the vessel lumen. To induce expression of the B, receptor of bradykinin, the vein segments are allowed to incubate at 37GC in a 25 ml chamber for 16 hours in an EMEM culture medium oxygenated by a 950/a 02 + 50/a CO2 mixture to which antibiotics are added: penicillin 10 000 lU/mi and streptomycin 10 000 lU/mI. The following day, the vein rings are mounted on a stainless steel support connected to an isometric sensor and placed in a 8 ml isolated organ bath chamber thermostated at 370C, containing the Krebs solution oxygenated by a 95% 02 + 5% CO2 mixture. After a rest period of one hour during which the rings are rinsed 5 to 6 times with the Krebs solution (maintained at 37GC throughout the entire handling procedure and oxygenated by a 950/a 02 + Sa/a CO2 mixture), the vein is gradually subjected to a ig load. When the load is stable, after approximately 45 minutes, the Krebs solution is replaced by a hyper-potassium solution (KPSS: at a temperature of 37GC) of the same composition but containing 125 mM KCI and not NaCI. After a series of rinsings, rests and load readjustments, the maximum contraction of each segment is determined by further depolarisation with the KPSS solution. After a new rest period during which the ig load is constantly readjusted, the following compounds are added to the isolated organ bath: Mepyramine (1 pM), Atropine (1 pM), Indometacine (3 pM), LNA (30 pM), Captopril (10 pM), DL-Thiorphan (1 pM) and Nifedipine (0.1 pM). After 20 minutes, the molecule to be tested or the molecule solvent is added to the isolated organ bath. The molecules are examined at 10 pM; should a molecule show a sufficient level of activity, it is examined at lower concentrations (eg: 1 — 0.1-0.01 pM). After 15 minutes incubation, the vein segments are contracted through the addition of increasing concentrations of des-ArglO-Kallidin (0.1 nM to 30 000 nM) in the chamber. The EC50 values (effective concentrations of agonists required to produce 5O0/a of the maximum response obtained with KPSS) are calculated using the least square method. (Table Removed) The pK8 = [-logK8] is obtained from the equation: KB = [A] / (concentration ratio-i) n which [A] is the concentration of antagonist and the (concentration ratio) represents the ratio between ECsa in the presence of an antagonist and EC50 in the absence of antagonist. According to this test, the compounds of the invention cited in the description show a PKB value of more than 7. By way of example, the pK8 values of some compounds of the invention are given in table II: The compounds of the present invention may be used to treat various forms of pain such as inflammatory hyperalgesia, allodynia, neuropathic pain assoicated with, for example, diabetes, with neuropathies (constriction of sciatica nerve, lumbago), with any form of trauma, surgery (tooth extraction, tonsil removal), interstitial cystitis, inflammatory colon disease, or with cancer. The compounds of the present invention may also be used to treat any pathology associated with neutrophil migration such as acute respiratory distress syndrome for example, or psoriasis, chronic lung obstructions, inflammatory diseases, in particular inflammatory diseases of the colon, rheumatoid polyarthritis. The activity of the compounds of the. invention, evidenced during the biological tests, is indicative of analgesic properties and permits their considered use for therapy. According to the invention, the use is advocated of compounds defined by formula I and of their salts with non-toxic acids, preferably their pharmaceutically acceptable salts, as active ingredients in medicinal products intended for the treatment of mammals, notably in man, suffering from pain or certain diseases generally characterized by massive neutrophil migration. Among the diseases which can be treated by administering a therapeutically efficient quantity of at least one of the formula I compounds, mention may be made of inflammatory hyperalgesia, neuropathic pain, pain assoicated with trauma or with cancer, inflammatory diseases of the colon, rheumatoid polyarthritis, psoriasis, chronic lung obstructions or acute respiratory distress syndrome. The invention also concerns a method for treating pain or the above-mentioned diseases which consists of administering a therapeutically efficient quantity of a formula I compound to patients in need thereof. The dose of active ingredient is dependent upon the mode of administration and type of pathology; it is generally between 0.05 and 10 mg/kg of the treated patient. In relation to the intended treatment, the formula I compounds or their salts may be associated with other active ingredients and are to be formulated with routinely used excipients. To obtain swift action, notably for the treatment of acute pain, the method of administration of the medicinal product is preferably by injection, for example via the intramuscular or the subcutaneous route. For chronic pain, the medicinal product may be administered in common galenic formulations, for example via the oral route in capsule or tablet form, in which a compound of the invention is associated with excipients known to persons skilled in the art, or in adhesive patch form in which a compound of the invention is formulated with excipients known to persons skilled in the art to promote transdermal passing of the active ingredient. The composition of present invention comprising at least one physiologically acceptable excipient, it contains at least one benzene surfonamide compound of Formula I or one of its pharmaceutically acceptable addition salts with an acid shows synergistic properties exhibiting surprising results. WE CLAIM: 1. A novel benzenesulphonamide compound, of formula I: (Formula Removed) in which - R1, R2, R3, R4 each independently represent one or more atoms or groups of atoms selected from a hydrogen atom, the halogens, C1-C3 alkyl groups, or C1-C3 alkoxy groups, CF3 or OCF3 groups, - Ra represents a C1-C4 alkyl group, - Y represents a saturated C2-C5 alkylene group, optionally interrupted by an oxygen atom, an unsaturated C2-C4 alkylene group, or a -CH2-CO-NH-CH2-group, - X represents CH or a nitrogen atom, - p represents 2 or 3, - A represents a single bond, a nitrogen atom optionally substituted with a methyl group, or a straight or branched C1-C5 alkylene group optionally hydroxylated or of which one of the carbon atoms is oxidized into a ketone function, provided that A and X together do not represent a nitrogen atom, - B represents a nitrogen-containing heterocycle or an amine group optionally substituted with one or two C1-C4 alkyl groups; or an addition salt of said compound with an acid. 2. A novel benzenesulphonamide compound as claimed in claim 1, wherein Y represents a C3-C5 alkylene group interrupted by an oxygen atom, preferably a-CH2-CH2-O-CH2- group. 3. A novel benzenesulphonamide compound as claimed in claim 1, wherein R2 and R3 represent a methyl group at position 2,6 on the aromatic ring. 4. A method for preparing a novel benzenesulphonamide compound of formula I as claimed in claim 1, and its addition salts, comprising the steps consisting of: a) allowing an acid of formula: (Formula Removed) in which R1, R2, R3 and R4 each independently represent a hydrogen or halogen atom, a C1-C3 alkyl group, or a C1-C3 alkoxy group, CF3 or OCF3 group, Ra represents a C1-C4 alkyl group, Y represents a saturated C2-C5 alkylene group, optionally interrupted by an oxygen atom, an unsaturated C2-C4 alkylene group, or a -CH2-CO-NH-CH2- group, to react with a nitrogen-containing heterocycle of formula: (Formula Removed) in which X represents CH or a nitrogen atom, p represents 2 or 3, A represents a single bond, a nitrogen atom optionally substituted with a methyl group (if X does not represent a nitrogen atom), or a straight or branched C1-C5 alkyl one group, optionally hydroxylated or of which one of the carbon atoms is oxidized into a ketone function, B represents a nitrogen-containing heterocycle or an amine group optionally substituted with one or two C1-C4 alkyl groups, on the understanding that, should a non-substituted nitrogen atom be present, this nitrogen atom is protected by an amino-protecting group, in a solvent selected from the group consisting of tetrahydrofuran, dichloromethane and dimethylformamide, in the presence of activators selected from the group consisting of EDCI (l-(3-dimethylaminopropyl)-3-ethylcarbodiimide), DIC (diisopropylcarbodiimide) and HOAT (l-hydroxy-7-azabenzotriazole), at a temperature lying between ambient temperature and the boiling point of the solvent, for approximately 2 to 15 hours, to obtain the amide of formula: (Formula Removed) in which R1, R2, R3, R4, Ra, Y, p, X, A and B maintain the same meaning as in the starting products, b) if necessary, removing the amino-protecting groups, c) if necessary, obtaining an addition salt of the formula I compound with a mineral or organic acid. 5. A novel benzenesulphonamide compound as claimed in claim 1 useful for the preparation of a pharmaceutical composition.

Full Text

Benzenesuiphonamide derivatives, method for production and
use thereof for treatment of pain

The present invention relates to novel benzenesulphonamide compounds, their method of preparation and pharmaceutical composition comprising these compounds;

These novel compounds are useful for treatment of pain.

Prior art
Compounds are already known whose structure includes a group of benzenesulphonamide type. For example, through EP 236 163 and EP 236 164, N-a-arylsulphonylaminoacyl-p-amidino-phenyl-alaninamide derivatives may be cited which are selective thrombin inhibitors and can be used as anti-thrombotics. Also, from EP 614 911, compounds are known having a fairly close structure to the preceding compounds, simultaneously containing an arylsulphamoyl group and a substituted phenylamidine group, which have the property of binding to receptors of the Y neuropeptide and can be used to treat hypertension, angina pectoris, atherosclerosis, depression, anxiety, inflammation, allergy or excess fat.
EP 558 961 also suggests the use of arylsulphonamide-type compounds of substituted amino acids for the treatment of thrombosis on account of their anticoagulant properties.
Studies on the anti-thrombotic properties of compounds containing an arylsulphonamide group in their structure and a phenylamidine group have also been published in Pharmazie 1984 vol. 39 (5) pages 315-317 and Pharmazie 1986 vol. 41(4) p 233-235.
In the same field of pharmacological activity WO 92/16549 Al describes derivatives of phenylalanine comprising an arylsulphonamide group, which are proteinase inhibitors, in particular thrombin inhibitors.
Also, according to WO 97/25315, compounds are known having N(arylsulphonyl)amino-acid structure, which can be used to treat inflammatory diseases.
Among the prior art documents proposing structural elements of arylsulphonamide type, mention may be made of WO 96/40639, WO 97/24349, WO 98/03503, WO 98/24783 and WO 99/00387, pertaining to antagonist compounds of the B2 receptor of bradykinin. Antagonist compounds of the B1 receptor of bradykinin, whether peptide or nonpeptide, are also known through documents WO 01/05783, WO 02/099388 and WO 97/09346.

Object of the invention
The invention concerns novel compounds comprising the substituted benzenesulphonamide chain, said compounds being notably useful as active ingredients in medicinal products intended to treat pain, in particular hyperalgesia and major algesia.

Description
According to the present invention, as novel industrial product a compound is proposed of benzenesulphonamide type, characterized in that it is selected from the group consisting of:
a) compounds of formula:
(Formula Removed)
in which
- R1, R2, R3, R4 each independently represent one or more atoms or groups of atoms selected from a hydrogen atom, halogens, C1-C3 alkyl groups, C1-C3 alkoxy groups, CF3 or OCF3 groups,
- Ra represents a C1-C4 alkyl group,
- Y represents a saturated C2-C5 alkylene group, optionally interrupted by an oxygen atom, an unsaturated C2-C4 alkylene group, or a —CH2-CO-NH-CH2- group,
- X represents CH or a nitrogen atom,
- p represents 2 or 3,
- A represents a single bond, a nitrogen atom optionally substituted with a methyl group, or a straight or branched C1-C5 alkylene group, optionally hydroxylated or of which one of the carbon atoms is oxidized into a ketone function, provided that A and X together do not represent a nitrogen atom,
- B represents a nitrogen-containing heterocycle or an amine group optionally substituted with one or two C1-C4 alkyl groups,
b) the addition salts of the above formula I compounds with an acid.
The invention, when the formula I compounds comprise a centre of assymetry, also concerns each of the optical isomers either pure or mixed, and their respective salts or salt mixtures.
According to the invention, a method is also proposed to prepare formula I compounds and their addition salts.
The use is also put forward of a substance selected from the formula I compounds and their non-toxic addition salts for the preparation of a medicinal product which can be used in human or animal therapy intended for the prevention or treatment of pain-related pathologies, in particular hyperalgesia subsequent to an inflammatory condition, or major algesia connected with other pathological conditions such as cancer for example.

Detailed description
In formula I, by alkyl group is meant a straight, branched or cyclized hydrocarbon chain. A C1-C3 alkyl group is notably a methyl, ethyl, propyl, cyclopropyl or 1-methyl-ethyl group. A C1-C4 alkyl group, in addition to the above-cited examples, will notably comprise butyl, 1-methylpropyl and 1,1-dimethylethyl groups.
By C1-C3 alkoxy group is meant an OR group in which R is a C1-C3 alkyl group, the term alkyl having the meaning given above. Said group is for example a methoxy, ethoxy, propoxy or 1-methylethoxy group.
By saturated C2-C5 alkylene group is meant a —(CH2)~- group in which n is 2, 3, 4 or 5 if it is a straight group or, for example a —CH(CH3)-CH2-CH2- or —C(CH3)2-CH2- group if it is a branched group. By an alkylene group interrupted by an oxygen atom is meant for example the groups —CH2-CH2-O-CH2-, -CH2-O-CH2-CH2- or even -CH2-CH2-O-CH2-CH2-. By unsaturated C2-C4 alkylene group, is meant a group comprising 2 to 4 carbon atoms of which 2 consecutive atoms are bound by an ethylene bond, for example the groups —CH2-CH=CH-CH2-, -CH=CH-CH2-, -CH =C(CH3)-CH2-, CH2-CH =CH- or —CH =CH-CH(CH3)-.
By halogen is meant an atom of fluorine, chlorine or bromine and preferably a fluorine or chlorine atom.
By alkylamino or dialkylamino groups is meant the NH(R) or N(R)2 groups in which R is a C1-C4 alkyl group, the term alkyl having the
-neaning given above.
By nitrogen-containing heterocycle is notably meant the azetidine, pyrrolidine, morpholine, piperidine, piperazine, N-(C1-C.4)alkylpiperidine, N
~C1-C4)alkylpiperazine, quinuclidine, tropane,
E~)alkylhomopiperazine, aminopyridine and N-(C1-C4)alkylimidazole rings.
By addition salts is meant the addition salts obtained by reaction of a formula I compound containing at least one basic function in its nonsalified form, with a mineral or organic acid. Preferably, these are pharmaceutically acceptable addition salts.
Among the mineral acids suitable for salifying a basic compound of formula I, preference is given to hydrochloric, hydrobromic, phosphoric and sulphuric acids. Among the organic acids suitable for salifying a basic compound of formula 1, preference is given to methanesulphonic, benzenesulphonic, toluenesulphonic, maleic, fumaric, oxalic, citric, tartaric, lactic and trifluoroacetic acids.
Among the formula I compounds, preference is given to those which meet at least one of the following conditions:
- R1 represents hydrogen, a halogen, a C1-C3 alkyl group or C1-C3 alkoxy group;
- R2 represents a halogen, a C1-C3 alkyl group or CF3 group;
- R3 represents hydrogen, a halogen, a C1-C3 alkyl group or C1-C3 alkoxy group;
- R4 represents hydrogen or a C1-C3 alkyl group;
- R.3 represents a methyl group;
- Y represents a saturated C2-C5 alkylene group, optionally interrupted by an oxygen atom;
- p represents 2;
A represents a single bond or a straight or branched C1-C5 alkylene
group;
B represents an azetidinyl, pyrrolidinyl, morpholinyl, piperidinyl,
piperazinyl, N-(C1-Q)alkylpiperidinyl, N-(C1-C4)alkylpiperazinyl,
quinuclidinyl, tropanyl or N-(C1-C4)alkylhomopiperazinyl group.
Particular preference is given to formula I compounds which meet at least one of the following conditions:
- R1 represents a C1-C3 alkoxy group;
- R2 and R3 each represent a C1-C3 alkyl group, preferably a methyl group at position 2,6 on the aromatic ring;
- R~ represents hydrogen;
- Y represents a C3-C5 alkylene group interrupted by an oxygen atom, preferably a —CH2-CH2-O-CH2- group;
- B represents a piperidinyl, N-(C1-C4)alkylpiperidinyl, or N-(C1-C4) alkylpiperazinyl group.
Preference is also given to compounds of formula Ia:
(Formula Removed)
in which
- R1, R2, R3 each independently represent one or more atoms or groups of atoms selected from a hydrogen atom, halogens, C1-C3 alkyl groups, C1-C3 alkoxy groups, CF3 or OCF3 groups,
- Y represents a saturated C2-C5 alkylene group, optionally interrupted by an oxygen atom, an unsaturated C2-C4 alkylene group or a —CH2-CO-NH-CH2- group,

- A represents a single bond or a (CH2)m group,
- R represents a saturated nitrogen-containing heterocycle, notably selected from the pyrrolidine, morpholine, piperidine, quinuclidine, tropane rings, or a tertiary amine group, notably a dialkylamino group,
- m and p each independently represent 2 or 3.
Preference is also given to compounds of formula Ib:
(Formula Removed)
in which
- R1, R2, R3 each independently represent one or more atoms or groups of atoms selected from a hydrogen atom, halogens, C1-C3 alkyl groups, C1-C3 alkoxy groups, CF3 or OCF3 groups,
- Y represents a saturated C2-C5 alkylene group, optionally interrupted by an oxygen atom, an unsaturated C2-C4 alkylene group, or a —CH2-CO-NH-CH2- group,
- A represents a single bond or a saturated C1-C5 alkylene group, optionally hydroxylated,
- R represents a saturated nitrogen-containing heterocycle notably selected from the N-methylpiperazine, N-methylpiperidine rings, or a tertiary amine group, notably a dialkylamino group.
According to the invention, a general method is put forth for preparing formula I compounds or their addition salts, comprising the steps consisting of:
a) allowing an acid of formula:
(Formula Removed)
in which
R1, R2, R3, R4 each independently represent one or more atoms or groups of atoms selected from a hydrogen atom, halogens, C1-C3 alkyl groups, C1-C3 alkoxy groups, CF3 or OCF3 groups, R8 represents a C1-C4 alkyl group, Y represents a saturated C2-C5 alkylene group, optionally interrupted by an oxygen atom, an unsaturated C2-C4 alkylene group, or a —CH2-CO-NH-CH2-group, to react with a nitrogen-containing heterocycle of formula:

(Formula Removed)
in which
X represents CH or a nitrogen atom, p represents 2 or 3, A represents a single bond, a nitrogen atom optionally substituted with a
methyl group (if X does not also represent a nitrogen atom), or a straight or branched C1-C5 alkylene group, optionally hydroxylated or of which one of the carbon atoms is oxidized into a ketone function, B represents a nitrogen-containing heterocycle or an amine group optionally substituted with one or two C1-C4 alkyl groups, on the understanding that if a non-substituted nitrogen atom is present, this nitrogen atom is protected by an amino-protecting group such as a Boc
group (1, 1-dimethylethoxycarbonyl) or Cbz group (phenylmethoxycarbonyl) for example, in a solvent such as tetrahydrofuran, dichloromethane or dimethylformamide for example, in the presence of activators such as
EDCI (1-(3-dimethylami nopropyl)-3-ethylcarbodiimide), DIC
(diisopropylcarbodiimide) or HOAT (1-hydroxy-7-azabenzotriazOle), at a temperature generally lying between ambient temperature and the boiling point of the solvent, for approximately 2 to 15 hours, to obtain the amide of formula:

(Formula Removed)
in which R1, R2, R3, R4, Ra, Y, p, X, A and B maintain the same meaning as in the starting products,
b) if necessary, removing the amino-protecting groups, for example through the action of trifluoroacetic acid in the presence of anisole if said amino-protecting group is a Boc group, or by catalytic hydrogenation if the protecting group is a Cbz group,
c) if necessary, obtaining an addition salt of the formula I compound with a mineral or organic acid, following usual procedures known to persons skilled in the art.
This general method for preparing an amide function starting with a carboxylic acid and an amine may be modified to use activators immobilized on an insoluble resin, for example resins having a polystyrene skeleton supporting carbodiimide functions.
As a variant of the above-described general method, the acid of formula II may be converted intermediately into an acid chloride of formula ha,
(Formula Removed)
notably through the action of a chlorinating agent such as oxalyl chloride or thionyl chloride, said acid chloride then being allowed to react with the nitrogen-containing heterocycle of formula III using a conventional reaction conducted in a solvent and preferably in the presence of an aprotic organic base such as triethylamine or pyridine for example, to obtain the compound of formula I.
The acids of formula II in which Y represents a -CH2-CH2-O-CH2-group may be prepared following a method consisting of:
a) allowing a benzenesulphonyl chloride of formula:

(Formula Removed)
in which R1, R2, R3 and R4 each independently represent a hydrogen or halogen atom, a C1-C3 alkyl group, a C1-C3 alkoxy group, CF3 or OCF3 group, to react with an aminoalcohol of formula:

in which P.8 represents a C1-C2 alkyl group, in a solvent such as dichloromethane for example, in the presence of an
aprotic organic base such as triethylamine or pyridine for example, at a temperature lying between approximately 0 and 50 0C, for approximately 1 to 3 hours, to obtain the sulphonamide of formula:

(Formula Removed)

in which R1, R2, R3, R4 and P.8 remain unchanged,
b) allowing the compound of formula V obtained above to react with an ester of bromacetic acid, preferably the t-butyl ester, in the presence of a base such as sodium hydroxide for example and in a phase-transfer promoting medium containing quarternary ammonium salts, in a mixture of solvents such as water and toluene, at a temperature lying between approximately 0 0C and 40 0C for approximately 1 to 5 hours, to obtain the ester of formula:
(Formula Removed)

c) hydrolysing the ester of formula VI, for example through the action of trifluoroacetic acid, the reaction being conducted in a solvent such as dichloromethane, at a temperature lying between approximately 0 0C and 50 0C for approximately 1 to 6 hours, to obtain the acid of formula II:
(Formula Removed)

in which R1, R2, R3, P.4 and Ra remain unchanged and Y represents a
-CH2-CH2-O-CH2- group.
As a variant of the general method, the formula I compounds may be obtained by successively performing the steps consisting of:
a) allowing an acid compound of formula:

(Formula Removed)

in which Ra represents a C1-C4 alkyl group, Y represents a saturated C2-C5 alkylene group, optionally interrupted by an
oxygen atom, and Za represents an amino-protecting group such as a benzyl group for example, to react with a nitrogen-containing heterocycle of formula:
(Formula Removed)
in which
X represents CH or a nitrogen atom,
p represents 2 or 3,

A represents a single bond, a nitrogen atom optionally substituted with a methyl group (if X does not also represent a nitrogen atom), or a straight or branched C1-C5 alkylene group optionally hydroxylated or of which one of the carbon atoms is oxidized into a ketone function, B represents a nitrogen-containing heterocycle or an amine group optionally substituted with one or two C1-C4 alkyl groups, on the understanding that, should a non-substituted nitrogen atom be present, this nitrogen atom is protected by a different amino-protecting group to the amino-protecting group used for acid compound VII, such as a Boc group (1,1-dimethylethoxycarbonyl), in a solvent such as tetrahydrofuran or dichloromethane or dimethylformamide for example, in the presence of activators such as
EDCI (1-(3-dimethylaminopropyl)-3-ethylcarbodiimide), DIC
(diisopropylcarbodiimide) or HOAT (1-hydroxy-7-azabenzotriazole) for example, at a temperature generally lying between ambient temperature and the boiling point of the solvent, for approximately 2 to 15 hours, to obtain the amide of formula:
(Formula Removed)
in which Za, Ra, Y, p, X, A and B maintain the same meaning as in the starting compounds,
b) removing the Za amino-protecting group, for example by catalytic hydrogenation if Za is a benzyl group, to obtain the secondary amine of formula:
(Formula Removed)
in which Ra, Y, p, X, A and B maintain the same meaning as in the preceding compound,
c) allowing this secondary amine IX to react with a benzenesulphonyl chloride of formula:

(Formula Removed)

in which R1, R2, R3 and R4 each independently represent a hydrogen or halogen atom, a C1-C3 alkyl group or a C1-C3 alkoxy group, CF3 or OCF3 group, in a solvent such as dichloromethane for example, in the presence of an aprotic organic base such as triethylamine or pyridine for example, at a temperature lying between approximately 0 and 50 0C, for approximately 1 to 3 hours, to obtain the sulphonamide of formula:
(Formula Removed)
in which R1, R2, R3, R4, Ra, Y, p, X, A and B maintain the same meaning as in the starting compounds,
d) if necessary, removing the amino-protecting groups, for example through the action of trifluoroacetic acid in the presence of anisole if said amino-protecting group is a Boc group,
e) if necessary, obtaining an addition salt of the formula I compound with a mineral or organic acid.
As a variant of the above method, step a) to form the amide bond may be conducted by first forming the acid chloride of formula VII, for example through the action of oxalyl chloride or thionyl chloride in an anhydrous aprotic solvent, followed by reaction of the acid chloride obtained with the formula III amine as described above, in a solvent and for example in the presence of an aprotic base such as triethylamine.
The heterocyclic derivatives of formula III are known compounds, commercially available or described in the literature, or may be prepared using methods known to persons skilled in the art, for example through a reductive amination reaction between piperazine or homopiperazine and a ketone, for example in the presence of titanium isopropoxide then a reaction with a reducing agent such as sodium cyanoborohydride, or, if piperidine derivatives are used, through catalytic hydrogenation of pyridine-homologous compounds.
The invention will be more readily understood with the help of examples of preparation of compounds and the results of pharmacological tests demonstrating the therapeutic usefulness of these compounds. These examples are non-limiting and cannot be interpreted as limiting the scope of the invention.
Among the abbreviations used in the description, M means mole, mM means millimole (10~ mole). THE means tetrahydrofurane, DCM means dichloromethane, DMF means dimethylformamide, TFA means trifluoroacetic acid. For compounds having a centre of assymetry, the absence of any particular indication means that the compound is in the form of the racemic mixture. In the spectral data for nuclear magnetic

resonance, chemical shifts are indicated with reference to TMS (tetramethylsilane).
PREPARATION I
N(2-hydroxyethyl)-4- methoxy- N, 2,6-trimethylbenzene-suiphonamide
A solution of 1.76 g (23.4 mM) of 2-(methylamino)ethanol is prepared in 100 ml of DCM and 5.4 g (53 mM) of triethylamine are added. The mixture is cooled to 0 0C and a solution of 5 g (21.3 mM) of 2,6 dimethyl4-methoxybenzenesulphonyl chloride in 50 ml of DCM is added progressively. The mixture is then agitated for 3 hours at ambient temperature, and then poured over 50 ml of 0.5 N hydrochloric acid. The organic phase is separated and then washed with water, dried over magnesium sulphate and concentrated under reduced pressure. 5.8 g of the compound sought after are thus obtained as a colourless oil (yield = 100 0/a)

'H NMR (300 MHz, DMSO) 8: 6.80 (s, 2H) ; 4.70 (t, 1H) ; 3.80 (5, 3H) ; 3.48 (q, 2H); 3.09 (t, 2H); 2.69 (s, 3H); 2.54 (s, 6H).

PREPARATION II
[2-([(4-methoxy-2,6-dimethylphenyl)sulphonyl]methylamino]-ethoxyjacetic acid, 1,1-dimethylethyl ester
A solution of 4.85 g (17.7 mM) of the compound obtained according to preparation I is prepared in 100 ml of toluene and 1.62 g of tetrabutylammonium chloride are added. The mixture is cooled to 0 0C and 100 ml of 350/a sodium hydroxide are then added, then, progressively, 3.95 ml (26.6 mM) of t-butyl bromacetate are added. The mixture is agitated at ambient temperature for 2 hours and the organic phase is then separated by decanting, and washed with water to neutral pH and then dried over sodium sulphate. After concentration under reduced pressure, an oil is obtained which is purified by silica gel chromatography in eluting

with the aid of a cyclohexane/ethyl acetate mixture (75/25; v/v). 6.5 g of the compound sought after are thus obtained as a colourless oil (yield =
94 0/~~)

'H NMR (250 MHz, DMSO) 8: 6.80 (s, 2H) ; 3.89 (s, 2H) ; 3.80 (s, 3H); 3.56 (t, 2H); 3.21 (t, 2H); 2.71 (s, 3H); 2.53 (s, 3H) ; 1.41 Cs, 9H).

PREPARATION III
[2-[[(4-methoxy-2,6-dimethylphenyl)sulphonyl]methylami no]ethoxyjacetic acid
6.4 g (16.5 mM) of the ester obtained according to preparation II are dissolved in 80 ml of DCM, and 8 ml of trifluoroacetic acid are added. The mixture is agitated at ambient temperature for 4 hours, and then concentrated under reduced pressure. The residue from evaporation is taken up into solution in 100 ml of iN sodium hydroxide and the solution obtained is washed twice with 30 ml of ethyl acetate, and then acidified with an N solution of hydrochloric acid and extracted with twice 80 ml of ethyl acetate. The organic phase is washed with water, dried over sodium sulphate and concentrated under pressure. The acid sought after is thus obtained as an oil which crystallises (yield = 95 0/a).
M.Pt. = 82 0C

Example 1
1-[[2-[[(4-methoxy-2,6-
dimethylphenyl)sulphonyl]methylamino]-ethoxy]acetyl]-4-[2-(1-pyrrolidinyl)ethyl] piperazine, bis-trifluoroacetate
482 mg cyclohexyldiimide grafted polystyrene resin are placed in 5 ml of THF for 20 minutes and 100 mg (0.31 mM) of the acid obtained according to preparation III in solution in 2 ml of THF, 37 mg (0.20 mM) of 1-[2-(1-pyrrolidinyl)ethyl]piperazine and 2 mg of HOAT (1-hydroxy-7-azabenzotriazole), are then added. The mixture is agitated for 4 hours at

ambient temperature and then filtered. The resin is rinsed with 4 ml of THF which is added to the filtrate. The filtrate is then agitated with 50 mg of Amberlite IRA 400 resin (as 0H), for 3 hours. After filtration, the resin is rinsed with 3 ml of THF which is added to the filtrate. This filtrate is then treated with 100 mg of isocyanate grafted polystyrene resin for 1 hour. The resin is separated off by filtration and the solution is concentrated under reduced pressure. The residue (63 mg) is purified by reverse phase chromatography on an X Terra Prep MS C18 column (eluent A : water + 0.05 0/0 TFA, eluent B : acetonitrile + 0.05 0/0 TFA, gradient 10 o/o B (t = 0 to 2 minutes) 60 0/0 B (t = 2 to 17 minutes) 100 % B (t =
17 minutes to 18 minutes); flow rate = 25 mI/mn; UV detection from
120 to 260 nm. The purified product is taken up into 1 ml of acetonitrile and it is mixed with 6 ml of a 10/0 solution of trifluoroacetic acid in water. The solution obtained is then freeze-dried and 19 mg of the salt sought after are obtained as a yellow oil (yield = 13 Gb).
'H NMR (300 MHz, CD3CN) 8: 6.74 (s, 2H) ; 4.09 (s, 2H) ; 3.96 (s, 3H) 3.70 (in, 1H) ; 3.59 (t, 2H) ; 3.48 (t, 2H) ; 3.33 (in, 5H) ; 3.19 (t, 2H)
3.00 (in, 4H); 2.72 (s; 3H); 2.56 (5, 6H) ; 2.04 (in, 4H).

PREPARATION IV [2-([(2,4,6-trimethylphenyl)sulphonyl]methylami nojethoxy]acetic acid, 1,1-dimethylethyl ester In operating analogously to preparation II, starting with N-(2-hydroxyethyl)-N,2,4,6-tetramethylbenzenesulphonamide, the ester sought after is obtained as a beige oil (yield = 98 %).
'H NMR (250 MHz, DMSO) 8: 7.06 (s, 2H) ; 4.01 (s, 2H) ; 3.58 (t, 2H) 3.25 (t, 2H); 2.72 Cs, 3H); 2.51 (s, 6H); 2.27 (s, 3H) ; 1.43 (s, 9H).

PREPARATION V [2-[[(2,4,6-trimethylphenyl)sulphonyl] methylaminojethoxy]acetic acid
In operating analogously to preparation III, starting with the compound obtained according to preparation IV, the product sought after is obtained as a beige solid (yield = 83 %).
M.Pt. = 58 0C

PREPARATION VI N-ethyl-N-(2-hydroxyethyl)-4-methOXy-2,6-dinlethylbenZene suiphonamide

In operating analogously to preparation I, starting with 2-(ethylamino)ethanol, the product sought after is obtained as a yellow oil (yield = 990/a).

'H NMR (250 MHz, DMSO) 8: 6.80 (s, 2H) ; 4.69 (t, 1H) ; 3.80 (s, 3H) 3.38 (in, 2H); 3.14 (5, 2H).

PREPARATION VII (2-[[(4-methoxy-2,6-dimethylphenyl)sulphonyl]ethylaminO]-ethoxy]acetic acid, 1, 1-dimethylethyl ester In operating analogously to preparation II, starting with the compound obtained according to preparation VI, the product sought after is obtained as a colourless oil (yield = 790/a). 'H NMR (250 MHz, DMSO) 8: 6.79 (s, 2H) ; 3.86 (s, 2H) ; 3.79 (s, 3H) 3.47 (t, 2H); 3.24 (in, 4H) ; 2.53 (s, 6H); 1.40 (s, 9H); 1.00 (t, 3H).

PREPARATION VIII [2- [[(4-methoxy-2,6-dimethylphenyl)suIphonyI]ethylamiflO]-ethoxyjacetic acid

In operating analogously to preparation III, starting with the compound obtained according to preparation VII, the product sought after is obtained as a white solid (yield = 88Gb).
'H NMR (250 MHz, DMSO) 8: 6.79 (s, 2H) ; 3.89 (s, 2H) ; 3.79 (s, 3H) 3.48 (t, 2H) ; 3.24 (q, 2H); 3.21 (t, 2H) ; 2.53 (s, 6H); 1.00 (t, 31-i).

PREPARATION IX

N-(2-hydroxyethyl)-4-methoxy-2,6-dimethyl-N-( 1-methylethyl)benzene-sulphonamide
In operating analogously to preparation I, starting with 2-[(1-inethylethyl)amino]ethanol, the product sought after is obtained as a colourless oil (yield = 58%).
'H NMR (300 MHz, DMSO) 8: 6.80 (s, 2H) ; 4.68 (t, 1H) ; 3.80 (s, 3H); 3.73 (quin, 1H) ; 3.27 (dt, 2H) ; 3.20 (q, 2H); 3.12 Ct, 2H) ; 2.53 (5, 6H)
1.06 (d, 6H) ; 0.99 (t, 3H).

PREPARATION X [2-[[(4-methoxy-2,6-dimethylphenyl)sulphonyl](1-methylethyl)amino]-ethoxy]acetic acid, 1,1-dimethylethyl ester In operating analogously to preparation II, starting with the compound obtained according to preparation IX, the product sought after is obtained as a colourless oil (yield = 950/o). 'H NMR (250 MHz, DMSO) 8: 6.80 (s, 2H) ; 3.86 (s, 2H) ; 3.80 (s, 3H) 3.74 (quin, 1H); 3.82 (in, 2H) ; 3.26 (in, 2H); 2.53 (s, 6H) ; 1.40 (s, 9H)
1.07 (d, 6H).

PREPARATION XI [2-[[(4-methoxy-2,6-dimethylphenyl)sulphonyl]( 1-methylethyl)amino]-ethoxy]acetic acid

In operating analogously to preparation III, starting with the compound obtained according to preparation X, the product sought after is obtained as a white solid (yield = 850/a).
M.Pt. = 96 0C

PREPARATION XII

N-cyclopropyl- N-(2-hydroxyethyl)-4-methoxy-2,6-dimethylbenzene-sulphonamide
In operating analogously to preparation I, starting with 2-(cyclopropylamino)ethanol, the product sought after is obtained as a white solid (yield = 770/a).
M.Pt. = 58GC

PREPARATION XIII [2-[cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulphonyl]
aminojethoxyjacetic acid, 1,1-dimethylethyl ester
In operating analogously to preparation II, starting with the compound obtained according to preparation XII, the product sought after is obtained as a colourless oil (yield = 84%).
'H NMR (300 MHz, DMSO) 8: 6.80 (s, 2H) ; 3.98 (s, 2H) ; 3.80 (s, 3H) 3.69 (t, 2H) ; 3.44 (t, 2H) ; 2.50 (s, 6H) ; 2.47 (in, 1H) ; 1.42 (s, 9H)
0.48 (in, 2H); 0.16 (in, 2H).

PREPARATION XIV [2-[cyc!opropyl[(4-methoxy-2,6-dimethyl phenyl)sulphonyl]aminojethoxyjacetic acid
In operating analogously to preparation III, starting with the compound obtained according to preparation XIII, the product sought after is obtained as a white solid (yield = 85Gb).
M.Pt. = 1000C
PREPARATION XV

2,6-dichloro-4-methoxybenzenesulphonyl chloride and 2,4-dichloro-6-methoxybenzenesulphonyl chloride
A solution is prepared of 15 g (84.7 mM) of 3,5-dichloroanisole in 8 ml of thionyl chloride that is cooled to — 100C, and 6 ml (90 mM) of chlorosulphonic acid are then added dropwise. The reaction mixture is then agitated for 3 hours at ambient temperature, and then poured over a mixture of ice and ethyl acetate. The organic phase is separated, dried over magnesium sulphate and concentrated under reduced pressure. The residue from evaporation is used, without other purification, in the next step.

PREPARATION XVIa

2,6-dichloro-N-(2-hydroxyethyl)-4-methoxy-N-methyl-benzenesulphonamide

PREPARATION XVIb
2,4-dichioro- N-(2-hydroxyethyl)-6-methoxy-N-methyl-benzenesulphonamide
In operating analogously to preparation I, starting with the sulphonyl chlorides obtained according to preparation XV, the products sought after are obtained as white solids, after separation of the compounds and purification by silica gel chromatography, in eluting with the aid of a toluene/isopropanol mixture (95/5 ;v/v).

PREPARATION XVIa (yield = 130/0) : M..Pt. = 470C
PREPARATION XVIb (yield = 480/o) : M.Pt. = 1000C

PREPARATION XVII [2-II(2,6-dichloro-4-methoxyphenyl)sulphonyl]methylamino]-ethoxyjacetic acid, 1, 1-dimethylethyl ester In operating analogously to preparation II, starting with the compound obtained according to preparation XVIa, the product sought after is obtained as a colourless oil (yield = S20bo).
'H NMR (300 MHz, DMSO) 8: 7.24 (s, 2H) ; 3.94 (s, 2H) ; 3.87 Cs, 3H) 3.60 (t, 2H); 3.39 t, 2H) ; 2.90 (s, 3H); 1.41 (s, 9H).

PREPARATION XVIII [2-[[(2,6-dichloro-4-methoxyphenyl)sulphonyljmethylamino]-ethoxy] acetic acid
In operating analogously to preparation III, starting with the compound obtained according to preparation XVII, the product sought after is obtained as a white solid (yield = 94%).
M.Pt. = 950C

PREPARATION XIX

[2-I [(2,4-dichloro-6-methoxyphenyl)sulphonyl]methylamino]ethoxy]acetic acid, 1,1-dimethylethyl ester
In operating analogously to preparation II, starting with the compound obtained according to preparation XVIb, the product sought after is obtained as an oil which is used, without other purification, in the next step.

PREPARATION XX
[2-[[(2,4-dichloro-6-methoxyphenyl)sulphonyl]methylamino]
ethoxyjacetic acid
In operating analogously to preparation III, starting with the compound obtained according to preparation XIX, the product sought after is obtained as a white solid (yield = 760bo).
M.Pt. = 740C

PREPARATION XXI

2,4-dichloro-N-(2-hydroxyethyO-3,N-dimethyl-benzenesulphonamide
In operating analogously to preparation I, starting with 2,4-dichloro-3-inethylbenzenesulphonyl chloride, the product sought after is obtained as a colourless oil.

PREPARATION XXII

[2-[[(2,4-dichloro-3-

methylphenyl)sulphonyl]methylamino]ethoxy]
acetic acid, 1,1-dimethylethyl ester
In operating analogously to preparation II, starting with the compound obtained according to preparation XXI, the product sought after is obtained as a colourless oil (yield = 87Gbo).
'H NMR (300 MHz, DMSO) 8: 7.83 (d, 1H) ; 7.63 (d, 1H) ; 3.93 (s, 2H); 3.59 Ct, 2H); 3.39 (t, 2H); 2.91 (s, 3H) ; 2.49 (5, 3H); 1.41 (5, 9H).

PREPARATION XXIII

[2-[ [(2,4-dichloro-3-

methylphenyl)sulphonyl]methylaminoJethoxy]acetic acid

In operating analogously to preparation III, starting with the compound obtained according to preparation XXII, the product sought after is obtained as a colourless oil (yield = 100%).
'H NMR (300 MHz, DMSO) 8:12.50 (in broad, 1H) ; 7.84 (d, 1H) ; 7.63 (d, 1H) ; 4.02 (s, 2H) ; 3.61 (t, 2H) ; 3.40 Ct, 2H) ; 2.91 (s, 3H) ; 2.51 (s, 3H).

PREPARATION XXIV N-(2- hydroxyethyl)- N-methyl-2-(trifluoromethyl)benzene-suiphonamide

In operating analogously to preparation I, starting with 2-(trifluoromethyl)benzenesulphonyl chloride, the product sought after is obtained as a yellow oil (yield = 990bo).
'H NMR (250 MHz, DMSO) 8: 8.02 (in, 2H) ; 7.88 (in, 2H) ; 4.84 (t, 1H); 3.55 (q, 2H); 3.30 (t, 2H); 2.93 (s, 3H).

PREPARATION XXV [2-[[[2-(trifiuoromethyl)phenyl]sulphonyl]methylamino]-ethoxyjacetic acid, 1, 1-d imethylethyl ester In operating analogously to preparation II, starting with the compound
obtained according to preparation XXIV, the product sought after is obtained as a yellow oil (yield = 670bo).
'H NMR (250 MHz, DMSO) 8: 8.02 (in, 2H); 7.98 (in, 2H); 3.97 (s, 2H); 3.63 (t, 2H) ; 3.44 Ct, 2H); 2.95 (s, 3H); 1.42 (s, 9H).

PREPARATION XXVI

[2-[[ [2-(trifluoromethyl)phenyl]sulphonyl]methylamino]-ethoxy]acetic acid

In operating analogously to preparation III, starting with the compound
obtained according to preparation XXV, the product sought after is obtained as a colourless oil (yield = 780h).
'H NMR (250 MHz, DMSO) 8: 8.02 (in, 2H) ; 7.86 (in, 2H); 4.01 (s, 2H) 3.65 (t, 2H) ; 3.45 (t, 2H) ; 2.95 Cs, 3H).

PREPARATION XXVII [2-~[4-methoxy-2-(trifiuoromethyI)phenyI]suIphonyI]-methylaminojethoxy] acetic acid A suspension is prepared of 8g (60 mM) of 2-(2-inethylaininoethoxy)acetic
acid in 100 ml of chloroform and 20 ml of acetonitrile, and, at ambient temperature, 17 ml (120 mM) of triethylamine are added, then, dropwise, 7.63 ml (60 mM) of chlorotriinethylsilane. The mixture is agitated at 600C for 2 hours and then cooled to ambient temperature and 17 ml (120 mM) of triethylainine and then 16.48 g (60 mM) of 4-methoxy-2-(trifluoroinethyl)benzenesulphonyl chloride in solution in 60 ml of chloroform, are added slowly. The reaction mixture is kept under agitation at 50C for 16 hours, and then concentrated under reduced pressure. The residue is taken up into 150 ml of dichloroinethane and is treated with 40 ml of an N solution of hydrochloric acid. The organic phase is separated, washed with water, and then extracted with twice 120 ml of N sodium hydroxide. The basic aqueous phase is separated, washed with 100 ml of dichloroinethane and then acidified with a SN solution of hydrochloric acid. The precipitate formed is extracted with twice 80 ml of dichloroinethane; the organic phase obtained is washed with water and then dried over magnesium sulphate and concentrated under reduced pressure. The residue obtained is crystallised in isopropyl ether, separated off and dried. 6.32 g of the compound sought after are thus obtained as a white solid (yield = 280/a).
M.Pt. = 600C

PREPARATION XXVIII
4-(3-quinuclidinyl)piperazine- 1-carboxytic acid, 1,1-dimethylethyl ester
1 g (8 mM) of quinuclidinone, 1.63 g (8.75 mM) of 1-piperazinecarboxylic acid t-butyl ester (1-Boc-piperazine) and 2.71 ml (9.1 mM) of titanium isopropoxide are mixed and this mixture is kept under agitation for 1 hour. 5 ml of ethanol and then 460 mg (7.3 mM) of sodium cyanoborohydride are then added, and this mixture is agitated for 24 hours at ambient temperature. 25 ml of water are added and agitation is carried out for 15 minutes. The precipitate formed is separated off by filtration and the filtrate is concentrated under reduced pressure. The residue is purified by NH2 silica gel chromatography in eluting with the aid of a toluene/isopropanol mixture (95/5; v/v). 1 g of the compound sought after are thus obtained as a white solid (yield = 42 0bo).
M.Pt. = 174 0C

PREPARATION XXIX

(3R5)-3-(1-piperazinyl)- 1-azabicyclo [2.2.2] octane or: (3(RS)-3-(1-piperazinyl)quinuclidine).

A solution is prepared of 990 ing (3.35 mM) of the compound obtained according to preparation XXVIII in 10 ml of trifluoroacetic acid and the mixture is agitated for 30 minutes at 10 GC. 30 ml of toluene are then added and concentration is carried out under reduced pressure. The residue is taken up into 25 ml of methanol and the solution is agitated with 20 g of Ainberlite IRA 400 resin (OH) for 1 hour at ambient temperature. The resin is separated off by filtration, rinsed with 15 ml of methanol and the combined filtrates are concentrated under reduced pressure. 530 ing of the product sought after are thus obtained as a white paste (yield = 80 0h).

'H NMR (300 MHz, DMSO) 8: 2.79 (in, 1H) ; 2.67 (in, 7H); 2.50 (in, 2H)

2.22 (in, 4H) ; 1.91 (in, 1H) ; 1.85 (in, 1H) ; 1.58 (in, 2H) ; 1.32 (in, 1H)
1.22 (in, 1H).

ExamDte 2
N-[2-[2-l14-[(3RS)- 1-azabicyclo[2. 2..2]oct-3-yI]-1-piperazinyl]-2-
oxo-ethoxy]ethyl]-N,2,4,6-tetramethylbenzenesulphonamide, bis trifluoro-acetate
250 ing (0.32 mM) of TFP (tetrafluorophenol) grafted polystyrene resin are placed in 4 ml of DMF for 15 minutes, and 4 ing (0.03 mM) of 4-(diinethylainino)pyridine, 103 mg (0.32 mM) of acid obtained according to preparation V and 76 p.1 (0.48 mM) of diisopropylcarbodiiinide, are then added. The mixture is kept under agitation for 18 hours, and the resin is then separated off by filtration, rinsed twice with 3 ml of DMF and allowed to react with 44 ing (0.225 mM) of the amine obtained according to preparation XXIX, in 3 ml of DMF. The mixture is agitated for 1 hour at ambient temperature and the resin is separated off by filtration and rinsed with twice 3 ml of DMF. The filtrates are combined and treated with 20 mg of Ainberlite IRA 400 resin (OH-), and then with 20 ing of isocyanate grafted resin, and then concentrated under reduced pressure. The residue is purified by semi-preparative chromatography (conditions analogous to those of Example 1). 16 ing of the compound sought after are thus obtained as a white solid (yield = 8 0bo).
M.Pt. = 78-80 0C

Example 3
N-112-[2-[4-[(3RS)- 1-azabicyclo[2. 2. 2]oct-3-yt]-1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy- N, 2,6-trimethylbenzene-suiphonamide

500 ing (1.51 mM) of acid obtained according to preparation III, 319 mg (1.65 mM) of EDCI, 2.26 ing (1.65 ing) of HOAT and 233 p.1 of triethylainine are mixed in 10 ml of DMF and this reaction mixture is kept under agitation at ambient temperature for 30 minutes. 334 mg of the amine obtained according to preparation XXIX are then added and agitation is carried out for 20 hours at ambient temperature. The reaction mixture is poured onto iced water and extracted with DCM. The organic phase is dried over magnesium sulphate and concentrated under reduced pressure. The residue is purified by NH2 grafted silica gel chromatography in eluting with a toluene/isopropanol mixture (95/5 ; v/v). 140 mg of the product sought after are thus obtained as a colourless oil (yield = 18 %).
'H NMR (300 MHz, DMSO) 8: 6.80 (s, 2H) ; 4.05 (s, 2H) ; 3.80 (s, 3H) ; 3.53 (t, 2H) ; 3.41 (in, 2H) ; 3.31 (in, 2H) ; 3.22 (t, 2H) ; 2.85 (in, 1H)
2.70 (s, 3H); 2.57 (in, 5H) ; 2.53 (s, 6H) ; 2.27 (in, 4H) ; 1.90 (in, 2H)
1.60 (in, 2H); 1.35 (in, 1H); 1.20 (in, 1H).

Example 4 N-[2-[2-[4-[(3RS)-1-azabicyclo[2.2.2]oct-3-yI]- 1- piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy- N, 2,6-trimethylbenzene-suiphonamide, difumarate A solution is prepared of 137 ing (0.269 mM) of the compound obtained according to Example 3 in 3 ml of methanol and 62.5 mg (0.538 mM) of fuinaric acid are added. The mixture is agitated for 30 minutes and then concentrated under reduced pressure. The residue is taken up into 5 ml of water and is freeze-dried. 200 ing of the salt sought after are thus obtained as a white powder (quantitative yield).
M.Pt. = 86-90 0C

Example 5
N-[2-[2-[4-lI(3S)- 1-azabicyclo[2.2.2]oct-3-yI]- 1-piperazinyl]-2-
oxo-ethoxy]ethyl]-4-methoxy- N, 2,6-trimethylbenzene-suiphonamide
840 ing (2.53 mM) of acid obtained according to preparation III are mixed in 8 ml of anhydrous toluene and 0.1 ml of DMF. 0.245 ml (2.81 mM) of oxalyl chloride are added slowly. The reaction mixture is agitated for an hour at ambient temperature and is then concentrated under reduced pressure. The residue is taken up into 10 ml of toluene and is added dropwise to a solution of 0.5 g (2.56 mM) of 3(S)-(1-piperazinyl)quinuclidine and 0.39 ml (2.81 mM) of triethylamine in 10 ml of toluene. The reaction mixture is agitated for an hour at ambient temperature and 2 ml of ethanol and 10 g of silica gel for chromatography are then added. The solvents are removed under reduced pressure and the product which is adsorbed on the silica is purified by silica gel chromatography in eluting with the aid of an ethyl acetate/ethanol/aqueous ammonia mixture (6/3/1 ; v/v/v). The pure fractions are concentrated under reduced pressure, taken up into solution in ethyl acetate, dried over magnesium sulphate and concentrated. The product sought after is thus obtained as a colourless oil (yield = 71 %).
'H NMR (300 MHz, DMSO) 8: 6.80 (s, 2H) ; 4.06 (t, 2H) ; 3.80 (s, 3H) ; 3.53 (t, 2H) ; 3.41 (in, 2H) ; 3.31 (in, 2H) ; 3.22 (t, 2H) ; 2.85 (in, 1H)
2.69 (s, 3H) ; 2.57 (in, 5H) ; 2.53 (s, 6H) ; 2.27 (in, 4H) ; 1.90 (in, 2H) ;
1.60 (in, 2H); 1.35 (in, 1H) ; 1.20 (in, 1H).

Exam~Ie 6
N-[2-[2-[4-[(3S)- 1-azabicyclo[2.2.2]oct-3-yI]- 1- piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy- N,2,6-trimethyl benzenesuiphonamide, fumarate
0.84 g (1.65 mM) of the compound obtained according to Example 5 are dissolved in 50 ml of methanol and 0.192 g (1.64 mM) of fuinaric acid are added. The mixture is agitated until complete dissolution and is concentrated under reduced pressure. The residue is taken up into solution in 40 ml of water, the solution is filtered and freeze-dried. 1 g of the salt sought after are thus obtained as a white powder (yield = 97%).
M.Pt. = 86 0C
[~]25D = -6.5 G (C = 0.31 ; CH3OH)

Examole 7
N-[2-[2-[4-[(3R)- 1-azabicyclo[2.2.2]oct-3-yI]-1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy- N,2,6-trimethylbenzene-suiphonamide, fumarate
The raceinic mixture obtained according to Example 3 is separated by chromatography on chiral phase (Chiralpack AD column) in eluting with a hexane/ethanol/isopropanol/trifluoroacetic acid mixture (60/25/15/0.05). Starting with 500 ing of the raceinic mixture, 260 ing of enantioiner S and 100 ing of enantioiner R are obtained. Each enantiomer is placed in solution in methanol and treated with 1 g of Ainberlite IRA 400 resin (0H). The treated solution is filtered and concentrated under reduced pressure and the basic compounds obtained are salified with fumaric acid, analogously to the operation described for Example 6. 143 mg of enantioiner S and 68 mg of enantioiner R are thus obtained.
M.Pt. = 84 0C
= 7.2 0 (C = 0.31 ; CH3OH)

PREPARATION XXX
4-(8-methyt-8-azabicyclo[3 .2. 1]oct-3-yI)- 1-piperazine-carboxylic acid, 1,1-dimethylethyl ester

In operating analogously to preparation XXVIII, starting with 8-inethyl-8-azabicyclo[3.2.1]octan-3-one (tropinone), the ester sought after is obtained as a white solid (yield = 53 Obo)
'H NMR (300 MHz, DMSO) 8: 3.25 (in, 4H) ; 3.15 (in, 2H) ; 2.51 (in, 2H) 2.35 (in, 4H) ; 2.20 Cs, 3H); 1.92 (in, 3H); 1.53 (in, 4H) ; 1.38 (s, 9H).

PREPARATION XXXI
8-methyl-3-( 1-piperazinyl)-8-azabicyclo[3.2. 1]octane
In operating analogously to preparation XXIX, starting with the compound obtained according to preparation XXX, the product sought after is obtained as a yellow oil (yield = 99 0/c,).
'H NMR (300 MHz, DMSO) 8: 3.70 (in, 2H) ; 3.03 (in, 4H) ; 2.75 (in, 1H) ; 2.61 (in, 4H) ; 2.53 Cs, 3H) ; 2.10 (in, 2H); 1.75 (in, 6H).

PREPARATION XXXII 4-(1-azabicyclo[2.2.2]oct-3-yI)hexahydro- 1H- 1,4-diazepine-1-carboxylic acid, 1, 1-dimethylethyl ester In operating analogously to preparation XXVIII, starting with 1-hoinopiperazinecarboxylic acid t-butyl ester, the product sought after is obtained as a colourless paste (yield = 67 0/a). 'H NMR (300 MHz, DMSO) 8: 3.34 (in, 4H) ; 2.81-2.35 (in, 11H) ; 1.88 (in, 1H) ; 1.65 (in, 4H); 1.39 Cs, 9H) ; 1.34 (in, 1H) ; 1.18 (in,1H).

PREPARATION XXXIII 3-(hexahydro-1H-1,4-diazepine-1-yI)-1-azabicyclo[2.2.2]octane
In operating analogously to preparation XXIX, starting with the compound obtained according to preparation XXXII, the product sought after is obtained as a yellow oil (yield = 98 Gbo).

'H NMR (250 MHz, DMSO) 6: 3.41 (in, 1H) ; 3.11 (in, 8H) ; 2.96 (in, 1H)
2.78 (in, 4H); 2.52 (in, 1H); 2.24 (in, 1H) ; 1.89 (in, 4H); 1.85 (in, 1H)
1.62 (in, 1H).

In operating analogously to Example 1, starting with kown piperazine derivatives described in the literature or described above, the following Examples are prepared:

Example 8
1- [[2-[[(4-methoxy-2,6-dimethyl phenyl)sulphonyl]methylamino]ethoxy]-acetyl ]-4-[3-(1-pyrrolidinyl)propyl]piperazine, bis-trifluoroacetate
Yield = 90 ~bo (colourless paste).
'H NMR (300 MHz, CD3CN) 8: 6.74 (5, 2H) ; 4.12 (s, 2H) ; 3.81 (s, 3H); 3.78 (in, 4H) ; 3.62 Ct, 2H) ; 3.34 Ct, 2H) ; 3.27 (in, 12H) ; 2.73 (s, 3H)
2.57 (s, 6H) ; 2.22 (in, 2H); 2.03 (in,4H).

Example 9 1-[[2-[[(4-methoxy-2,6-dimethylphenyl)sulphonyl]methyl-amino]-ethoxy]-acetyl]-4-[2-(4-morpholinyt)ethyl]piperazine, bis-trifi uoroacetate Yield = 51 0/a (colourless paste) 'H NMR (300 MHz, CD3CN) 6: 6.75 (5, 2H) ; 4.11 Cs, 2H); 3.92 (in, 4H); 3.81 (s, 3H) ; 3.76 (in, 4H) ; 3.61 Ct, 2H) ; 3.48 (in, 4H) ; 3.35 (t, 2H)
3.27 (in, 8H); 2.72 (s, 3H); 2.57 (s, 6H).

Example 10
1- [[2-[[(4-methoxy-2,6-dimethyl phenyl)sulphonyl]methylamino]ethoxy]acetyl]-4-[2-( 1-piperidinyl)ethyl]piperazine, bis-trifluoroacetate

Yield = 92 Gbo (colourless paste)
'H NMR (300 MHz, CD3CN) 6: 6.74 (s, 2H) ; 4.10 (s, 2H) ; 3.81 (s, 3H)
3.81 (in, 4H); 3.61 (t, 2H); 3.40 (in, 2H); 3.34 (in, 4H); 3.24 (in, 4H)

3.09 (in, 4H); 2.74 (s, 3H); 2.57 (s, 6H); 1.90 (in, 4H); 1.64 Cm, 2H).

Example 11 1-[[2-flX4-methoxy-2,6-dimethylphenyl)sulphonyl]methyl-amino]ethoxy]acetyl]-4- [3-(1-piperidinyl)propyl]piperazine, bis-trifi uoroacetate Yield = 85 0/~ (colourless paste). 'H NMR (300 MHz, CD3CN) 8: 6.74 (s, 2H) ; 4.10 (s, 2H) ; 3.96 (s, 3H); 3.80 (in, 2H) ; 3.60 (t, 2H) ; 3.50 (in, 4H) ; 3.30 (t, 2H) ; 3.15 (in, 2H)
3.10 (in, 4H); 2.80 (in, 4H); 2.75 (s; 3H); 2.55 (s, 6H); 2.20 (in, 2H)
1.93 (in, 5H); 1.37 (in, 1H).

Example 12 1-[[2-[[(4-methoxy-2,6-dimethylphenyl)sulphonyl ]methylamino]-ethoxy]-acetyl]-4-[3-(dimethylamino)propyl] piperazine, bis-trifi uoroacetate Yield = 74 % (colourless paste) 'H NMR (300 MHz, CD3CN) 8 : 6.74 (s, 2H) ; 4.11 (s, 2H) ; 3.81 (s, 3H) 3.78 (in, 4H) ; 3.63 (t, 2H) ; 3.31 (t, 2H) ; 3.22 (in, 4H); 3.15 (in, 4H)
2.81 (s, 6H); 2.74 (s, 3H); 2.57 (s, 6H); 2.23 (in, 2H).

In operating analogously to Examples 3 and 4, starting with derivatives of piperazine or of hoinopiperazine described above, the following Examples are prepared

Example 13 4-methoxy-N,2,6-trimethyl-N- [2- [2- [4-(l-methyl-4-piperidinyl)-
1-piperazinyl]-2-oxoethoxy]ethyl]benzenesu Iphonamide,
bis trifluoroacetate
Yield = 74 0/a (colourless paste)
'H NMR (300 MHz, CD3CN) 8 : 6.74 (s, 2H) ; 4.11 (s, 2H) ; 3.81 (s, 3H) 3.80 (in, 4H); 3.77 (d, 2H) ; 3.64 (in, 2H); 3.55 (in, 1H) ; 3.34 (t, 2H);
3.26 (in, 4H) ; 3.01 (in, 2H) ; 2.79 Cs, 3H) ; 2.74 (s, 3H) ; 2.57 (s, 6H)
2.29 (in, 4H).

Example 14 4-methoxy-N,2,6-trimethyl-N-[2-[2-[4-(8-methyl-8-azabicyclo[3.2. 1]-oct-3-yI)-1-piperazinyl]-2-oxoethoxy]ethyl]-benzenesulphonamide, fumarate Yield = 62 0/0 (white solid) M.Pt. = 88-90 0C

Example 15
1-( 1-azabicyclo[2.2.2]oct-3-yI)hexahydro-4-[[2-[[(4-methoxy-
2,6-dimethylphenyl)sulphonyl]methylamino]ethoxy]acetyl]- iN1,4-diazepine, fumarate
Yield = 47 0/0 (white solid)
M.Pt. = 90 0C
PREPARATION XXXIV
4-[ 1-( 1, 1-dimethylethyl)-4-piperidinyl]- 1-piperazinecarboxylic
acid, phenylmethyl ester
In operating analogously to preparation XXVIII, starting with 1-(1,1-
diinethylethyl)-4-piperidinone and the benzyl ester of 1-

piperazinecarboxylic acid, the product sought after is obtained as a white solid (yield = 560bo).
M.Pt. = 70-72 0C

PREPARATION XXXV
1-[ 1-( 1,1-dimethylethyl)-4-piperidinyl] piperazine
A solution is prepared of 570 mg (1.59 mM) of the compound obtained according to preparation XXXIV in 20 ml of methanol and 114 ing of 100/0 palladium on carbon are added. The mixture is agitated under an atmosphere of hydrogen for 2 hours at ambient temperature and at atmospheric pressure. The catalyst is removed by filtration and the filtrate is concentrated under reduced pressure. The crude product is purified by silica gel chromatography in eluting with the aid of a dichloroinethane/methanol/aqueous ammonia mixture (90/10/1 ; v/v/v). 270 ing of the compound sought after are thus obtained as a white powder (yield = 750bo).
M.Pt. = 1060C

PREPARATION XXXVI
4-(9-methyl-9-azabicycio[3.3.1]non-3-yI)-1-piperazinecarboxylic acid, phenylmethyl ester
In operating analogously to preparation XXVIII, starting with 9-inethyl-9-azabicyclo[3.3.1]nonan-3-one and the benzyl ester of 1-piperazinecarboxylic acid, the product sought after is obtained as a pale yellow solid (yield = l8Obo).
M.Pt. = 74 0C

PREPARATION XXXVII
1-(9-methyl-9-azabicyclo[3.3. lJnon-3-yI)piperazine
In operating analogously to preparation XXXV, starting with the compound obtained according to preparation )O0(VI, the product sought after is obtained as a yellow oil (yield = lOOObo).
'H NMR (300 MHz, D20) 8: 3.74 (in, 2H); 3.59 (in, 1H); 3.43 (in, 4H);
3.15 Cm, 4H) ; 3.01 and 2.97 (2s, 3H) ; 2.46 (dd, 1H) ; 2.30 (in, 2H)
2.10 (in, 4H); 1.83 (in, 3H).

PREPARATION XXXVIII 4-(1,2,2,6,6-pentamethyl-4-piperidinyl)- 1-piperazinecarboxylic acid, phenylmethyl ester In operating analogously to preparation XXVIII, starting with. 1,2,2,6,6-pentainethyl-4-pi peridinone and the benzyl ester of 1-pi perazi necarboxyl ic acid, the product sought after is obtained as a colourless oil (yield =
520bo).

'H NMR (300 MHz, DMSO) 8: 7.36 Cm, 5H); 5.07 (s, 2H); 3.37 Cm, 4H); 2.85 (in, 1H); 2.50 (in, 7H) ; 1.80 (in, 2H); 1.48 (in, 2H); 1.28 Cs, 6H);
1.21 (s, 6H).

PREPARATION XXXIX
1-(1,2,2,6,6-pentamethyl-4-piperidinyl)piperazine
In operating analogously to preparation XXXV, starting with the compound obtained according to preparation XXXVIII, the product sought after is obtained as a white solid (yield = 350/o).
M.Pt. = 650C

PREPARATION XL
4-[ 1-( 1-methylethyl)-4-piperidinyl]- 1-piperazinecarboxylic acid, 1, 1-dimethylethyl ester
In operating analogously to preparation XXVIII, starting with 1-Cl-methylethyl)-4-piperidinone, the product sought after is obtained as a yellow solid (yield = 31%).
M.Pt. = 53 0C

PREPARATION XLI
1-[1-( 1-methylethyl)-4-piperidinyl]piperazine, trihydrochioride
A solution is prepared of 247 mg (0.79 mM) of the compound obtained according to preparation XL in 1 ml of methanol, and 15 ml of a 2.3 N solution of hydrogen chloride in ethyl acetate are added. The mixture is agitated for 4 hours at ambient temperature. The reaction mixture is concentrated under reduced pressure. 239 ing of the compound sought after are thus obtained as a white powder.(yield = 750h).
M.Pt. = 262GC

PREPARATION XLII
4-C 1-cyclopropyl-4-piperidrnyl)-1-piperazinecarboxylic acid, phenylmethyl ester
In operating analogously to preparation XXXIV, starting with 1-cyclopropyl-4-piperidinone, the product sought after is obtained as a white solid (yield = 67%).
M.Pt. = 88 0C

PREPARATION XLIII
1-(1-cyclopropyl-4-piperidinyl)piperazi ne

In operating analogously to preparation XXXV, starting with the compound obtained according to preparation XLII, the product sought after is obtained as a white solid (yield = 92%).
M.Pt. = 580C

PREPARATION XLIV 4-(1-methyl-4-piperidinyl)hexahydro- XH-1,4-diazepine- 1-carboxylic acid, 1,1-dimethylethyl ester
In operating analogously to preparation XXXII, starting with 1-methyl-4-piperidinone, the product sought after is obtained as a yellow oil (yield =
78%).
'H NMR (250 MHz, CDCI3) 8: 3.43 (in, 4H); 3.10 (din, 2H) ; 2.70 (in, 4H) 2.61 (in, 1H); 2.44 (s, 3H) ; 2.28 (in, 2H) ; 1.86 (in, 6H); 1.45 Cs, 9H).

PREPARATION XLV
1-( 1-methyl-4-piperidinyl)hexahydro- 1H- 1,4-diazepine, trihydrochioride
In operating analogously to preparation XLI, starting with the compound obtained according to preparation XLIV, the product sought after is obtained as a beige solid (yield = 990bo).
M.Pt. = 186GC

PREPARATION XLVI
4-(8-cyclopropyl-8-azabicyclo[3.2. 1]oct-3-yI)-1-piperazinecarboxylic acid, 1, 1-dimethylethyl ester In operating analogously to preparation XXVIII, starting with 8-
cyclopropyl-8-azabicycloll3 .2. 1]octan-3-one, the ester sought after is obtained as a white paste (yield = 45 0/a).
'H NMR (300 MHz, DMSO) 8: 3.24 (in, 6H) ; 2.50 Cm, 5H); 2.34 (t, 4 H); 1.87 (in, 3H); 1.48 (dd, 6H); 1.38 Cs, 9H); 0.36 (in, 2H); 0.25 (in, 2H).

PREPARATION XLVII
8-cyclopropyl-3-(1-piperazinyl)-8-azabicyclo[3.2. ijoctane In operating analogously to preparation XXIX, starting with the compound obtained according to preparation XLVI, the product sought after is obtained as a white solid (yield = 95 0/o). 'H NMR (250 MHz, CDCI3) 8: 3.37 Cm, 2H); 2.94 (t, 2H) ; 2.58 (in, 4H); 2.51 Cm, 1H); 1.96 Cm, 3H); 1.74 Ct, 2H); 1.54 Cm, 4H) ; 0.43 Cd, 4H).

PREPARATION XLVIII
4- [ 1-[(1, 1-dimethylethoxy)carbonylJ-4-piperidinyl]- 1-piperazinecarboxylic acid, phenylmethyl ester
In operating analogously to preparation )O(XIV, starting with the t-butyl ester of 4-oxo-1-piperidinecarboxylic acid, the product sought after is obtained as a yellow oil (yield = 30%).

'H NMR (250 MHz, DM50) 8: 7.35 (in, 5H) ; 5.06 Cs, 2H) ; 3.93 (d, 2H); 3.36 (in, 4H) ; 2.68 Ct, 2H) ; 2.44 Ct, 4H) ; 2.37 Cm, 1H) ; 1.66 Cm, 2H)

1.38 (s, 9H); 1.26 Cm, 2H).

PREPARATION IL
4-(4-piperidinyl)- 1-piperazinecarboxylic acid, phenylmethyl ester
In operating analogously to preparation XXIX, starting with the compound obtained according to preparation XLVIII, the product sought after is obtained as a yellow oil (yield = 100%).

'H NMR (250 MHz, DMSO) 8 : 8.91 (in broad, h) ; 8.63 (in broad, 1H) 7.36 (in, 5H); 5.11 Cs, 2H); 3.80 Cm, 2H); 3.45 Cm, 4H) ; 3.22 Cm, 5H);

2.92 (q, 2H) ; 2.20 Cd, 2H); 1.82 (dq, 2H).

PREPARATION L
4-(1-ethyl-4-piperidinyl)- 1-piperazinecarboxylic acid, phenylmethyl ester
In operating analogously to preparation XXXIV, starting with acetaldehyde and the compound obtained according to preparation IL, the product sought after is obtained as a colourless oil (yield = 720bo).
'H NMR (250 MHz, DMSO) 8: 7.34 Cm, SH); 5.07 Cs, 2H) ; 3.90 (in, 7H); 3.02 (q, 2H) ; 2.84 Cm, 2H) ; 2.45 Ct, 4H) ; 1.91 Cm, 2H) ; 1.63 Cm, 2H)
1.19 (t, 3H).

PREPARATION LI
1-(1-ethyl-4-piperidinyl)piperazine
In operating analogously to preparation XXXV, starting with the compound obtained according to preparation L, the product sought after is obtained as a yellow oil (yield = 71%).
'H NMR (250 MHz, DMSO) 8: 2.90 (in, 6H); 2.52 (in, 4H); 2.30 (q, 2H); 2.17 (tt, 1H); 1.85 Cdt, 2H); 1.69 (in, 2H); 1.38 (dq, 2H) ; 0.97 Ct, 3H).

PREPARATION LII
4-[8-[(1, 1-dimethylethoxy)carbonyl]-8-azabicyclo[3.2. 1]oct-3-yI]-1-p;perazinecarboxylic acid, phenylmethyl ester
In operating analogously to preparation XXVIII, starting with the t-butyl ester of 3-oxo-8-azabicyclo[3 .2.1 ]octa ne-8-carboxyl ic acid, the ester sought after is obtained as a white solid (yield = 40 Obo).
'H NMR (250 MHz, CD3CN) 8: 7.33 (in, 5H) ; 5.07 Cs, 2H) ; 4.13 (in, 2H); 3.37 Ct, 4H); 2.80 (hep, 1H); 2.43 Ct, 4H); 1.87 Cm, 2H); 1.62 (in, 6H);
1.42 Cs, 9H).

PREPARATION LIII
4-(8-azabicyclo[3.2. 1]oct-3-yI)- 1-piperazineca rboxylic acid, phenylmethyl ester, hydrochloride
In operating analogously to preparation XLI, starting with the compound obtained according to preparation LII, the product sought after is obtained as a colourless oil (yield = 96 0bo).
'H NMR (250 MHz, DMSO) 6:11.78 (m broad, 1H) ; 9.45 Cs, 2H) ; 7.38 (in, SH) ; 5.11 Cs, 3H) ; 4.09 (in, 4H) ; 3.95 Cm, 1H) ; 3.43 Cm, 4H); 3.07 (in, 2H) ; 2.22 Cm, 4H); 1.92 (in, 4H).

PREPARATION LIV 4-(8-ethyl-8-azabicyclo(3.2. 1]oct-3-yl)-1-piperazinecarboxylic acid, phenylmethyl ester In operating analogously to preparation XXXIV, starting with acetaldehyde and the compound obtained according to preparation LIII, the product sought after is obtained as a colourless oil (yield = 99 0A,).
'H NMR (250 MHz, CD3CN) 6: 7.33 (in, 5H) ; 5.07 Cs, 2H) ; 3.39 Cm, 6H) ; 2.63 (in, 1H); 2.56 (q, 2H); 2.42 Ct, 4H); 1.93 (in, 2H); 1.61 Cm, 6H); 1.06 (t, 3H).

PREPARATION LV
1-(8-ethyl-8-azabicyclo[3.2. 1]oct-3-yl)piperazine
In operating analogously to preparation XXXV, starting with the compound obtained according to preparation LIV, the product sought after is obtained as a colourless oil (yield = 78 Gbo).
'H NMR (300 MHz, CDCI3) 8: 3.57 (in, 2H) ; 2.94 Ct, 2H) ; 2.71 (q, 2H); 2.59 Cm, 4H); 2.52 Cm, 1H); 1.99 Cm, 4H); 1.64 Cm, 4H).

PREPARATION LVI
4-[8-(1-methylethyl)-8-azabicyclo[3.2. 1]oct-3-yI]- 1-
piperazineca rboxyl ic acid, phenylmethyl ester
In operating analogously to preparation XXXIV, starting with acetone and the compound obtained according to preparation LIII, the product sought after is obtained as a colourless oil (yield = 77 %).
'H NMR (250 MHz, CDCI3) 8: 7.32 (in, 5H) ; 5.12 Cs, 2H); 3.64 (in, 2H)
3.49 Ct, 4H) ; 2.92 (quin, 1H) ; 2.59 (hep, 1H) ; 2.47 Cm, 4H) ; 1.99 (in, 2H); 1.82 Cdt, 2H); 1.63 Cm, 2H); 1.48 (in, 2H); 1.14 Cd, 6H).

PREPARATION LVII 1-[8-(1-methylethyl)-8-azabicyclo[3.2. 1]oct-3-yI] piperazine
In operating analogously to preparation XXXV, starting with the compound obtained according to preparation LVI, the product sought after is obtained as a colourless oil (yield = 82 0bo).
'H NMR (250 MHz, CDCI3) 6: 3.79 (in, 2H) ; 3.05 (quin, 1H) ; 2.98 Cm, 4H) ; 2.71 (hep, 1H) ; 2.61 Cm, 4H) ; 2.13 (in, 2H) ; 1.95(m, 2H) ; 1.65 (in, 4H); 1.29 Cd, 6H).

PREPARATION LVIII Hexahydro-1-methyl-4-(1-oxo-2-propenyl)- 1H- 1,4-diazepine A solution is prepared of 20 g (175 mM) of N-methylhomopiperazine in 100 ml of dichloromethane, to which is added, dropwise, at 0 0C, a solution of 15.85 g (175 mM) of acryloyl chloride in 20 ml of dichloromethane. The reaction mixture is agitated for 1 hour at 00C, and then for 2 hours at ambient temperature, and then hydrolysed with a solution of 12 g of sodium carbonate in 20 ml of water. The mixture is decanted, the organic phase is washed once with water and then dried over magnesium sulphate and concentrated under reduced pressure. 23 g

of the compound sought after are thus obtained, as an orangy oil, which is used, without other purification, in the next step.

PREPARATION LIX
4- [3-(hexahydro-4-methyl- 1H-1,4-diazepin- 1-yI)-3-oxopropyl]-
1-pi perazineca rboxylic acid, phenylmethyl ester
A solution is prepared of 7g (41 mM) of the compound obtained according to preparation LVIII in 100 ml of toluene, to which 11 g (50 mM) of the benzyl ester of 1-piperazinecarboxylic acid are added. The reaction mixture is agitated for 16 hours under reflux of the solvent, and then concentrated under reduced pressure. The residue is taken up into ethyl acetate and the organic phase is washed once with water and then dried over magnesium sulphate and concentrated under reduced pressure. The crude product is purified by silica gel chromatography in eluting with the aid of a toluene/isopropanol/aqueous ammonia mixture (80/20/1 ; v/v/v). 4.1 g of the compound sought after are thus obtained as a yellow oil (yield
= 26 0/a)

'H NMR (250 MHz, DMSO) 8: 7.36 (in, SH); 5.06 Cs, 2H) ; 3.47 (in, 4H); 3.37 Cm, 4H); 2.50 Cm, 8H) ; 2.35 Cm, 4H); 2.24 and 2.21 (2s, 3H); 1.75 (in, 2H).

PREPARATION LX
1-[3-(hexahydro-4-methyl- 1H- 1,4-d iazepin- 1-yI)-3-oxopropyl]piperazine
In operating analogously to preparation XXXV, starting with the compound obtained according to preparation LIX, the product sought after is obtained as a colourless oil (yield = 65 0b~).
'H NMR (250 MHz, DMSO) 8: 3.48 (in, 4H) ; 2.67 Ct, 4H) ; 2.48 Cm, 8H) 2.30 Ct, 4H) ; 2.25 and 2.22 (2s, 3H); 1.73 (in, 2H).

PREPARATION LXI
1- [3-(hexahydro-4-methyl- 1H- 1,4-diazepin- 1-yI)propyl]piperazine
A suspension is prepared of 120 ing (3.1 mM) of lithium aluminium hydride in 3 ml of tetrahydrofuran (THF) and a solution of 800 mg (3.1 mM) of the compound obtained according to preparation LX in 10 ml of THF is added. The reaction mixture is heated under gentle reflux of the solvent for 4 hours, and then cooled to ambient temperature. 200 ing of Glauber's salt are added to the reaction mixture and then, after around 15 minutes, 50 ml of ethyl acetate are added. The suspension obtained is filtered and the filtrate is concentrated under reduced pressure. The crude product is purified by silica gel chromatography in eluting with the aid of a dichloromethane/methanol/aqueous ammonia mixture (80/20/10; v/v/v). The product sought after is thus obtained as a colourless oil (yield = 34

'H NMR (250 MHz, DMSO) 8: 2.64 Ct, 4H); 2.57 (in, 4H) ; 2.49 (in, 4H); 2.38 Ct, 2H) ; 2.23 Cm, 6H) ; 2.21 Cs, 3H) ; 1.66 (quin, 2H) ; 1.52 (quin, 2H).

PREPARATION LXII
4-[2-(hexahydro-4-methyl- 1H- 1,4-diazepin- 1-yI)-2-oxoethyl]-1-piperazinecarboxyl Ic acid, phenylmethyl ester
A solution is prepared of 10 g (87.5 mM) of N-methylhomopiperazine in 200 ml of dichloromethane, to which 36.6 ml of triethylamine are added. The mixture is cooled to —780C and 6.97 ml of chloroacetyl chloride are added dropwise. The reaction mixture is agitated for 1.5 hours at —780C, and a solution of 19.3 g (87.6 mM) of the benzyl ester of 1-piperazinecarboxylic acid in 10 ml of dichloromethane is then added. The mixture is then left to come back to ambient temperature, and agitation is carried out for 15 hours. The medium is then hydrolysed with a solution of

sodium carbonate. The mixture is decanted, the organic phase is washed once with water and then dried over magnesium sulphate and concentrated under reduced pressure. The crude product is purified by silica gel chromatography in eluting with the aid of a dichloromethane/methanol/aqueous ammonia mixture (90/10/5; v/v/v). The product sought after is thus obtained as a yellow oil (yield = 43 O/~). 'H NMR (250 MHz, DMSO) 8: 7.36 (in, SH); 5.07 Cs, 2H) ; 3.55 (in, 2H); 3.44 (in, 2H); 3.38 (in, 4H); 3.16 Cd, 2H); 2.60 Cm, 2H); 2.44 (in, 6H)
2.24 and 2.22 (2s, 3H); 1.76 Cm, 2H).

PREPARATION LXIII
1-[2-(hexahydro-4-methyl- 1H- 1,4-diazepin-1-yI)-2-oxoethyl ]piperazine
In operating analogously to preparation XXXV, starting with the compound obtained according to preparation LXII, the product sought after is obtained as a colourless oil (yield = 60 0b~).
'H NMR (250 MHz, DMSO) 8: 3.56 Cm, 2H); 3.44 Cm, 2H); 3.10 Cd, 2H); 2.74 (dd, 4H) ; 2.61 (in, 1H2.44 Cm, 4H) ; 2.39 (in, 3H) ; 2.25 and 2.22 C2s, 3H); 1.78 Cm, 2H).

PREPARATION LXIV 1-[2-(hexahydro-4-methyl- 1H-1,4-diazepin-1-yI)ethyl]piperazine
In operating analogously to preparation LXI, starting with the compound obtained according to preparation LXIII, the product sought after is obtained as a yellow oil Cyield = 21 Obo).
'H NMR (300 MHz, DMSO) 8: 2.63 (in, 8H) ; 2.49 Cm, SH); 2.28 Cm, 7H) 2.21 Cs, 3H); 1.66 (quin, 2H).

PREPARATION LXV
1-( 1-oxo-2-propenyl)azetidine

In operating analogously to preparation LVIII, starting with azetidine, the product sought after is obtained as a yellow oil which is allowed to react in the following preparation without purification.

PREPARATION LXVI
4-[3-(1-azetidinyl)-3-oxopropyl]- 1-piperazinecarboxylic acid, phenylmethyl ester
In operating analogously to preparation LIX, starting with the compound obtained according to preparation LXV, the product sought after is obtained as a yellow oil (yield = 14 0bo).
'H NMR (250 MHz, DMSO) 8: 7.34 (in, SH); 5.06 (s, 2H); 4.09 Ct, 2H); 3.80 Ct, 2H) ; 3.35 (in, 4H); 2.48 Ct, 2H) ; 2.33 Ct, 4H) ; 2.16 (in, 4H).

PREPARATION LXVII
1-[3-(1-azetidinyl)-3-oxopropyl]piperazine
In operating analogously to preparation XXXV, starting with the compound obtained according to preparation L)(VI, the product sought after is obtained as a yellow solid Cyield = 100 0bo).
M.Pt. = SOGC

PREPARATION LXVIII
1-[3-( 1-azetidinyl)propyl]piperazine
In operating analogously to preparation LXI, starting with the compound obtained according to preparation L)(VII, the product sought after is obtained as a yellow oil (yield = 30 0/a).
'H NMR (300 MHz, DMSO) 8: 3.19 (in broad, 1H) ; 3.02 Ct, 4H); 2.66 (t, 4H); 2.25 (in, 8H); 1.93 (quin, 2H); 1.36 (quin, 2H).

PREPARATION LXIX
a-[(dimethylamino)methyl]-4-piperidinemethanol
20 g (83.6 mM) of 2-II(dimethylamino)methyl]-4-pyridinemethanol dihydrochloride are dissolved in 200 ml of methanol at 50 0C. 2 g of platinum oxide are then added under an atmosphere of nitrogen, and the mixture is agitated under an atmosphere of hydrogen, at 50 0C, under a pressure of 300 hPa C3 bars), for 7 hours. This catalyst is then removed by filtration and the filtrate is concentrated under reduced pressure. The solid residue is taken up with 10 ml of iON sodium hydroxide and 150 ml of chloroform. The organic phase is separated and washed with a solution of sodium chloride, dried over magnesium sulphate and concentrated under reduced pressure. The product sought after is thus obtained as an oil which crystallises (yield = 87 0/a).
M.Pt. = 98GC

PREPARATION LXX
4-(1-pyrrolidinylmethyl)piperidine
In operating analogously to preparation LXIX, starting with 4-(1-pyrrolidinylmethyl)pyridine, the product sought after is obtained as a yellow oil.

PREPARATION LXXI
4-[(4-(1-methylethyl)-1-piperazinyl]- 1-piperidinecarboxylic acid, phenylmethyl ester
A mixture is prepared of 827 mg (3.54 mM) of the benzyl ester of 4-oxo-1-piperidinecarboxylic acid, 500 mg (3.9 mM) of N-isopropylpiperazine and 1.2 g (4.25 mM) of titanium isopropoxide in 10 ml of methanol. 148 mg of sodium borohydride are added under agitation and at ambient temperature. The reaction mixture is kept under agitation for 16 hours, and then diluted with 20 ml of water. The suspension obtained is filtered and the precipitate is washed with 30 ml of ethyl acetate which is then used to extract the filtrate. The organic phase obtained is washed with

water and then dried over magnesium sulphate and concentrated under reduced pressure. The yellow oil obtained is purified by silica gel chromatography in eluting with the aid of a dichloromethane/methanol mixture (9/1 ; v/v). 235 mg of the product sought after are thus obtained as a white solid (yield = l90/a).
M.Pt. = 550C

PREPARATION LXXII
4-[4-(1-methylethyl)- 1-piperazinyl]piperidine
In operating analogously to preparation XXXV, starting with the ester obtained following preparation LXXI, the product sought after is obtained as a white solid (yield = 980bo).
M.Pt. = 65GC

PREPARATION LXXIII
4-[(4-methyl- 1-piperazinyl)methyl]- 1-piperidinecarboxylic acid, phenylmethyl ester
In operating analogously to preparation LXXI, starting with Nmethylpiperazine and the benzyl ester of 4-formyl-1-piperidinecarboxylic acid, the product sought after is obtained as a colourless oil (yield = 52%)
'H NMR (250 MHz, DMSO) 8 : 7.34 Cm, 5H) ; 5.05 Cs, 2H) ; 3.98 (in, 2H) ; 2.77 Cm, 2H); 2.29 (in, 8H) ; 2.19 Cs, 3H); 2.08 (d, 2H) ; 1.67 Cm, 3H)
0.95 (in, 2H).

PREPARATION LXXIV
4-[(4-methyl-1-piperazinyl)methyl]piperidine
In operating analogously to preparation XXXV, starting with the ester obtained following preparation LXXIII, the product sought after is obtained as a colourless oil (yield = 77~b~).

'H NMR (250 MHz, DMSO) 6: 2.89 (in, 2H) ; 2.51 (in, 2H); 2.28 Cm, 8H)
2.12 Cs, 3H); 2.05 Cd, 2H) ; 1.55 Cm, 3H); 1.02 (in, 2H).

PREPARATION LXXV 4-[(1-azetidinyl)methyl]-1-piperidinecarboxylic acid, phenylmethyl ester
In operating analogously to preparation LXXIII, starting with azetidine, the product sought after is obtained as a colourless oil (yield = 69%).
'H NMR (300 MHz, DMSO) 8: 7.34 Cm, 5H); 5.04 Cs, 2H); 3.95 Cm, 2H); 3.06 (t, 4H); 2.75 (in, 2H); 2.18 Cd, 2H); 1.94 (quin, 2H); 1.61 (in, 2H)
1.38 Cm, 1H) ; 0.94 (in, 2H).

PREPARATION LXXVI
4-[(1-azetidinyl)methyl]piperidine
In operating analogously to preparation XXXV, starting with the ester obtained following preparation LXXV, the product sought after is obtained as a colourless oil (yield = 930bo).
'H NMR C250 MHz, DMSO) 8: 3.06 (t, 4H); 2.92 Cm, 2H); 2.50 Cm, 2H);
2.15 Cd, 2H) ; 1.91 (quin, 2H) ; 1.59 Cm, 2H) ; 1.30 (in, 1H) ; 1.00 (in, 2H).

PREPARATION LXXVII
4-[(dimethylamino)methyl]- 1-piperidinecarboxylic acid, phenylmethyl ester
In operating analogously to preparation LXXIII, starting with diinethylamine, the product sought after is obtained as a colourless oil (yield = 780h).
'H NMR (300 MHz, DMSO) 8: 7.35 (in, 5H) ; 5.05 (5, 2H); 3.97 (in, 2H) 2.79 (in, 2H); 2.09 Cs, 6H) ; 2.02 Cd, 2H); 1.68 Cd, 2H); 1.61 (in, 1H)
0.96 Cm, 2H).
PREPARATION LXXVIII
4-[(dimethylami no)methyl]piperidine
In operating analogously to preparation )OO(V, starting with the ester obtained following preparation LXXVII, the product sought after is obtained as a colourless oil (yield = 900/a).
'H NMR (300 MHz, DMSO) 8 : 2.91 Cm, 2H); 2.43 (in, 2H); 2.08 Cs, 6H); 2.01 Cd, 2H); 1.59 (in, 2H); 1.49 Cm, 1H); 0.96 (dq, 2H).

PREPARATION LXXIX
4-[(4-ethyl- 1-piperazinyl)methyl]- 1-piperidinecarboxylic acid, 1,1-dimethylethyl ester
In operating analogously to preparation LXXIII, starting with Nethylpiperazine and the t-butyl ester of 4-formyl-1-piperidinecarboxylic acid, the product sought after is obtained as a colourless oil (yield =
780bo).

'H NMR (300 MHz, DMSO) 8: 3.90 (in, 2H); 2.67 Cm, 2H) ; 2.29 Cm, 1OH) 2.09 Cd, 2H); 1.63 Cm, 3H); 1.38 Cs, 9H); 0.96 Ct, 3H); 0.85 Cm, 2H).

PREPARATION LXXX
4-[(4-ethyl- 1-piperazinyl)methyl]piperidine
In operating analogously to preparation XXIX, starting with the ester obtained following preparation LXXIX, the product sought after is obtained as a colourless oil (yield = 760/a).
'H NMR (250 MHz, DMSO) 8: 2.95 (in, 2H); 2.51 (in, 2H); 2.42 (in, 1OH) 2.05 Cd, 2H); 1.54 Cm, 3H); 1.03 Cm, 2H) ; 0.99 Ct, 3H).

PREPARATION 000(1
4-[(hexahydro-4-methyl- 1H- 1,4-diazepin-1-yI)methyl]- 1-
piperidi ne-carboxylic acid, 1, 1-dimethylethyl ester
In operating analogously to preparation LXXIX, starting with N-methylhomopiperazine, the product sought after is obtained as a colourless oil (yield = 830/a).

'H NMR (300 MHz, DMSO) 8 : no 'H NMR

PREPARATION LXXXII
4-[(hexahydro-4-methyl- 1H-1,4-diazepin- 1-yI)methyl]pi peridi ne
In operating analogously to preparation XXIX, starting with the ester obtained following preparation 1)00(1, the product sought after is obtained as a colourless oil (yield = 23%).
'H NMR (250 MHz, DMSO) 6: 3.03 Cm, 2H) ; 2.57 Cm, 5H); 2.50 Cm, SH) 2.25 Cs, 2H); 2.22 Cs, 3H); 1.68 Cm, 4H); 1.63 Cm, 1H); 1.08 (in, 2H).

PREPARATION LXX)(III
4-(hexahydro-4-methyl- 1H-1,4-diazepin-1-yI)-1-piperidinecarboxylic acid, 1,1-dimethylethyl ester In operating analogously to preparation L)0(I, starting with N-methylhomopiperazine and the t-butyl ester of 4-oxo-1-piperidinecarboxylic acid, the product sought after is obtained as a yellow oil (yield = 360bo). 'H NMR (250 MHz, CDCI3) 8: 4.15 (in, 2H) ; 2.82 Cm, 4H) ; 2.70 (in, 7H)
2.42 Cs, 3H); 1.87 (in, 2H); 1.98 (in, 2H); 1.45 Cs, 9H); 1.40 (in, 2H).

PREPARATION LXXXIV
4-(hexahydro-4-methyl- 1H-1,4-diazepin- 1-yI)piperidine, trihydrochioride
409 mg (1.37 mM) of the compound obtained according to preparation LXXXIII are dissolved in 1 ml of methanol and 27 ml of a 2.3 N solution of hydrogen chloride in ethyl acetate are added. The mixture is agitated at ambient temperature for 12 hours and then concentrated under reduced
pressure. The product sought after is thus obtained as a beige foam (yield
= 990/o)

'H NMR (250 MHz, DMSO) 8: 3.88 (in, 4H); 3.62 Cm, 1H); 3.43 (in, 6H) 2.94 (in, 2H) ; 2.82 Cs, 3H); 2.31 (in, 4H); 2.10 (in, 2H).

PREPARATION L)OO(V
4-(4-cyclopropyl- 1-piperazinyl)-1-piperidinecarboxylic acid, phenylmethyl ester
In operating analogously to preparation LXXI, starting with Ncyclopropylpiperazine, the product sought after is obtained as a white solid (yield = 62%).
M.Pt. = 64GC

PREPARATION LXXXVI
4-(4-cyclopropyl-1-piperazinyl)piperidine
In operating analogously to preparation L)O(II, starting with the ester obtained following preparation LXXXV, the product sought after is obtained as a white solid (yield = 90%).
M.Pt. = 1070C

PREPARATION LXXXVII
4-[4-(1, 1-dimethylethyl)- 1-piperazinyl]- 1-piperidinecarboxylic acid, phenylmethyl ester
In operating analogously to preparation LXXI, starting with N-tbutylpiperazine, the product sought after is obtained as a white solid (yield
= SO0bo).

M.Pt. = 840C
PREPARATION LXXXVIII
4-[4-( 1, 1-dimethylethyl)- 1- piperazinyl] piperidine
In operating analogously to preparation LXXII, starting with the ester obtained following preparation LXXXVII, the product sought after is obtained as a white solid (yield = 750/o).
M.Pt. = 82GC

PREPARATION L)OO(IX
4-(4-piperidinyl)- 1-piperidinecarboxylic acid, 1,1-dimethylethyl ester
A solution is prepared of 41 g (0.17 M) of 4,4'-bipiperidine dihydrochloride in 250 ml of ethanol and 250 ml of 2N sodium hydroxide. A solution of 18.5 g (0.085 M) of t-butyl dicarbonate in 100 ml of ethanol are added slowly, at 0 0C. The reaction mixture is agitated for 1 hour at 1OGC and the ethanol is then removed by an evaporator, under reduced pressure. The residual aqueous phase is saturated with sodium chloride and extracted with ethyl acetate. The organic phase obtained is dried over magnesium sulphate and concentrated under reduced pressure. The crude product is purified by silica gel chromatography in eluting with the aid of a dichloromehane/methanol/aqueous ammonia mixture (8/2/0.4; v/v/v). 16.5 g of the compound sought after are thus obtained as a white solid (yield = 72 %).
M.Pt. = 70-710C

PREPARATION XC
4-( 1-ethyl-4-piperidinyl)- 1-piperidinecarboxylic acid, 1,1-dimethylethyl ester
In operating analogously to preparation LXXI, starting with the ester obtained following preparation LXXXIX and acetaldehyde, the product sought after is obtained as a white solid (yield = 870bo).
M.Pt. = 68-70 0C

PREPARATION XCI
4-(1-ethyl-4-piperidinyl)piperidine, dihydrochioride
In operating analogously to preparation LXXXIV, starting with the ester obtained following preparation XC, the product sought after is obtained as a white solid (yield = lOOObo).
M.Pt. = 2800C

PREPARATION XCII
4-[1-(1-methylethyl)-4-piperidinyl]- 1-piperidinecarboxylic acid, 1,1-dimethylethyl ester
In operating analogously to preparation XC, starting with the ester obtained following preparation LXXXIX and acetone, the product sought after is obtained as a colourless oil (yield =
'H NMR (250 MHz, CDCI3) 8: 4.10 Cm, 2H) ; 3.52 Cm, 1H); 3.47 Cm, 2H) 2.55 Cm, 4H); 1.88 Cm, 4H); 1.85 Cm, 4H); 1.45 Cs, 9H); 1.30 Cd, 6H);
1.12 (in, 2H).

PREPARATION XCIII 4-[1-(1-methylethyl)-4-piperidinyl]piperidine, dihydrochioride In operating analogously to preparation LXXXIV, starting with the ester obtained following preparation XCII, the product sought after is obtained as a white solid (yield = 890h). M.Pt. = 2500C

PREPARATION XCIV
4-( 1-cyclopropyl-4-piperidinyl)- 1-piperidinecarboxylic acid,
1,1-dimethylethyl ester
150 mg (0.56 mM) of the compound obtained according to preparation
LXXXIX are dissolved in 5 ml of methanol and 320 p1 of acetic acid and
200 mg of 3A molecular sieves, and then 562 p1(2.79 mM) of 1-ethoxy-1-(trimethylsilyloxy)cyclopropane and 141 mg (2.23 mM) of sodium borohydride, are added. The reaction mixture is heated under gentle reflux for 20 hours, and then cooled and filtered. The filtrate is concentrated under reduced pressure and the residue from evaporation is taken up into 20 ml of ethyl acetate. This organic phase is washed with a 2N solution of sodium hydroxide, and then with a saturated solution of sodium chloride, dried over magnesium sulphate and concentrated under reduced pressure. The crude product is purified by silica gel chromatography in eluting with the aid of a dichloromehane/methanol mixture (95/5; v/v). 110 mg of the compound sought after are thus obtained as a white powder (yield = 64 %).
'H NMR (250 MHz, CDCI3) 8: 4.10 (in, 2H); 3.05 (in, 4H); 2.65 Ct, 2H); 2.09 Ct, 2H) ; 1.67 Cm, 4H) ; 1.55 (in, 1H) ; 1.45 (s, 9H) ; 1.22 (in, 6H)
0.47 (in, 4H).

PREPARATION XCV
4-(1-cyclopropyl-4-piperidinyl)piperidine, dihydrochioride
In operating analogously to preparation LXXXIV, starting with the ester obtained following preparation XCIV, the product sought after is obtained as a white paste (yield = 99%).
'H NMR (250 MHz, DMSO) 8: 10.50 (in broad, 1H); 8.80 Cm broad, 2H); 3.45 (in, 2H); 3.16 (in, 2H) ; 2.81 (in, 2H) ; 2.73 (in, 3H); 1.90 (in, 4H);
1.60 Cm, 2H); 1.35 (in, 4H); 1.10 (in, 2H); 0.78 Cm, 2H).

PREPARATION XCVI
4-[2-(4-piperidinyl)ethyl]-1-piperidinecarboxylic acid, 1,1-dimethylethyl ester

In operating analogously to preparation LXXXIX, starting with 4,4'-ethylenedipiperidine hydrochloride, the product sought after is obtained as a white solid (yield = 390h).
M.Pt. = 92-940C

PREPARATION XCVII
4-[2-(1-methyl-4-piperidinyl)ethyl]piperidine
A solution is prepared of 307 mg (1.04 mM) of the ester obtained following preparation XCVI in 20 ml of anhydrous tetrahydrofuran (ThF) and 157 mg (4.14 mM) of lithium aluminium hydride are added portionwise. The reaction mixture is agitated for 10 hours at 700C and then cooled and diluted with 30 ml of THF. 200 mg of Glauber's salt are added and the mixture is left under agitation at ambient temperature overnight, and then filtered. The filtrate is concentrated under reduced pressure to give 235 mg of the product sought after as a white paste (yield = 990bo).

'H•NMR (300 MHz, DM50) 8: 3.16 Cs, 2H); 2.80 Cm, 2H) ; 2.70 Cm, 2H); 2.38 Ct, 2H) ; 2.10 Cs, 3H) ; 1.76 (in, 2H) ; 1.58 Cm, 3H) ; 1.42 Cm, 1H) ;
1.11 Cm, 8H); 0.94 (in, 2H).

PREPARATION XCVIII
4-[2-(4-methyl- 1-piperazinyl)ethyl]pyridine
In a tube, 2 ml (19 mM) of 4-vinylpyridine, 3.16 ml (28.5 mM) of Nmethylpiperazine, and 200 p1 of acetic acid are mixed in 12 ml of ethanol. The tube is closed and heated for 10 minutes at 16OGC in a microwave oven. After cooling, 20 ml of 0.5N sodium hydroxide are added slowly and the mixture is extracted with dichloromethane. The separated organic phase is dried over magnesium sulphate and concentrated under reduced pressure. The product sought after is thus obtained as a yellow oil (yield =
86%).

'H NMR (250 MHz, DMSO) 8: 8.43 (dd, 2H); 7.25 (dd, 2H); 2.73 Ct,
2H); 2.52 (in, 2H); 2.48 (in, 4H) ; 2.30 Cm, 4H); 2.13 Cs, 3H).

In operating analogously to preparation XCVIII, the following pyridine derivatives are obtained

PREPARATION IC
4-[2-(1-piperidinyl)ethyt]pyridine
yellow oil (yield = 52%)
'H NMR (250 MHz, DM50) 8: 8.43 (dd, 2H); 7.24 (dd, 2H); 2.73 Ct, 2H) 2.49 Cm, 2H) ; 2.37 Ct, 2H); 1.43 Cm, 6H).

PREPARATION C
4-[2-[(methyl)(1-methylethyl)amino]ethyl]pyridine
yellow oil (yield = 10%).
'H NMR (250 MHz, DMSO) 8: 8.49 Cd, 2H) ; 7.16 Cd, 2H); 2.76 (hep, 1H) 2.65 Ct, 2H); 2.56 Cd, 2H) ; 2.15 Cs, 3H); 0.90 Cd, 6H).

PREPARATION CI
4-[2-(4-morpholinyl)ethyl]pyridine
yellow oil (yield = 72%).
'H NMR (250 MHz, DMSO) 8: 8.44 (dd, 2H); 7.26 (dd, 2H); 3.05 (dd, 4H) ; 2.75 Ct, 2H); 2.53 Cm, 2H); 2.41 (dd, 2H).

PREPARATION CII
4-[2-(1-azetidinyl)ethyl]pyridine
yellow oil (yield = 620bo).
'H NMR (300 MHz, DMSO) 8: 8.43 (d, 2H); 7.22 (d, 2H); 3.07 Ct, 4H); 2.53 (in, 4H); 1.91 (quin, 2H).

PREPARATION CIII
(Methyl)[2-(4-pyridinyl)ethyl]carbamic acid, 1, 1-dimethylethyl ester
yellow oil (yield = 830bo).
'H NMR (300 MHz, DMSO) 8: 8.45 Cd, 2H) ; 7.21 Cd, 2H); 3.42 Ct, 2H) 2.76 Ct, 2H) ; 2.75 (5, 3H); 1.23 Cs, 9H).

PREPARATION CIV
4-(2-[(methyl)(ethyl)amino]ethyl]pyridine
colourless oil (yield = 510bo).
'H NMR (300 MHz, DMSO) 8: 8.50 Cd, 2H) ; 7.25 Cd, 2H); 2.73 Ct, 2H) 2.55 Ct, 2H) ; 2.43 (q, 2H); 2.23 Cs, 3H); 0.90 (t; 3H).

PREPARATION CV
4-[2-(diethylamino)ethyl]pyridine
yellow oil (yield = 30~bo).
'H NMR (250 MHz, DMSO) 8: 8.43 (dd, 2H); 7.24 (dd, 2H); 2.65 (in, 4H); 2.40 (q, 4H) ; 0.93 Ct, 6H).

PREPARATION CVI 4-[2-(hexahydro-4-methyl —1H- 1,4-diazepin- 1-yI)ethyl]pyridine yellow oil (yield = 520/o) 'H NMR (250 MHz, DMSO) 8: 8.43 Cd, 2H); 7.25 (d, 2H); 2.71 Cm, 8H); 2.50 Cm, 4H); 2.22 Cs, 3H); 1.68 Cm, 2H).

PREPARATION CVII
4-[2-(4-methyl- 1-piperazinyl)ethyl]piperidine

In operating analogously to preparation LXIX, starting with the compound obtained according to preparation XCVIII, the product sought after is obtained as a yellow solid (yield = 800/o).
M.Pt. = 111-112 0C

PREPARATION CVIII
4-[2-(dimethylamino)ethyljpiperidine
In operating analogously to preparation CVII, starting with 4-[2-(dimethylamino)ethyl]pyridine, the product sought after is obtained as a colourless oil (yield = 960/a).
'H NMR (300 MHz, DMSO) 8: 2.86 (2H); 2.39 Cdt, 2H); 2.18 Cdd, 2H); 2.08 Cs, 6H); 1.54 (din, 2H); 1.27 (in, 3H) ; 0.96 Cm, 2H).

PREPARATION CIX
4-[2-(1-pyrrolidinyl)ethyl]piperidine
In operating analogously to preparation CVII, starting with 4-[2-(1-pyrrolidinyl)ethyl]pyridine, the product sought after is obtained as a colourless oil (yield = 880/o).
'H NMR (300 MHz, DMSO) 8: 2.86 (din, 2H); 2.38 (in, 8H) ; 1.64 (in, 4H) 1.54 (din, 2H); 1.32 Cm, 3H) ; 0.96 (dq, 2H).

In operating analogously to preparation CVII, starting with the compounds obtained according to preparations IC to CVI, the following piperidine derivatives are obtained

PREPARATION CX
4-[2-(1-piperidinyl)ethyl]piperidine
yellow oil (yield = 920bo).
'H NMR (300 MHz, DMSO) 8: 3.10 (din, 2H); 2.67 Cdt, 2H); 2.27 Cm, 6H); 1.70 Cm, 2H); 1.47 Cm, 5H); 1.35 (in, 4H); 1.23 Cm, 2H).

PREPARATION CXI

4-[2-[(methyl)( 1-methylethyl)amrno]ethyl]piperidine
yellow oil (yield = 960/o).
'H NMR (250 MHz, DMSO) 8: 3.10 Cd, 2H); 2.77 Cm, 1H); 2.60 Cm, 2H); 2.35 Ct, 2H); 2.10 Cs, 3H); 1.72 (in, 2H); 1.34 Cm, 1H); 1.29 Ct, 2H);
1.23 (in, 2H); 0.91 Cd, 6H).

PREPARATION CXII

4-[2-(4-morpholinyl)ethyl]piperidine
colourless oil (yield = 98%).
'H NMR (300 MHz, DMSO) 8: 3.54 Ct, 4H); 2.86 Cdt, 2H); 2.39 Cdt, 2H); 2.28 Cm, 4H); 2.25 Ct, 2H); 1.54 (din, 2H); 1.31 (in, 3H); 0.97 Cm, 2H).

PREPARATION CXIII

4-[2-(1-azetidinyl)ethyl]piperidine

colourless oil (yield = 740/o).
'H NMR (250 MHz, DMSO) 8: 3.16 Ct, 4H) ; 3.12 Cm, 2H); 2.65 Cm, 2H); 2.35 Ct, 2H); 1.94 (quin, 2H); 1.85 Cm, 2H); 1.35 (in, 1H) ; 1.23 Ct, 2H) ; 1.15 (in, 2H).

PREPARATION CXIV

(Methyl)[ 2-(4-piperidinyl)ethyl]carbamic acid, 1,1-dimethylethyl ester
colourless oil (yield = 64%).
'H NMR (300 MHz, DMSO) 8: 3.16 Ct, 2H); 2.89 (din, 2H) ; 2.73 Cs, 3H) 2.40 Ct, 2H); 1.38 Cs, 9H); 1.35 Cm, 2H) ; 0.96 Cm, 2H).

PREPARATION CXV
4-[2-[(methyl)(ethyl)amino]ethyl]piperidine

colourless oil (yield = 98%).
'H NMR (300 MHz, DMSO) 8: 3.13 (in, 2H); 2.68 Cm, 2H); 2.32 (in, 4H)
2.11 (5, 3H) ; 1.85 (in, 2H) ; 1.51 Cm, 1H) ; 1.34 Ct, 2H) ; 1.24 Cm, 2H)
0.96 Ct, 3H).

PREPARATION CXVI

4-[2-(diethylamino)ethyl]piperidine
yellow oil (yield = 870/a).
'H NMR (250 MHz, DM50) 8: 2.87 (din, 2H) ; 2.40 (in, 8H) ; 1.54 (din, 2H); 1.26 Cm, 3H); 0.98 (in, 2H) ; 0.91 Ct, 6H).

PREPARATION CXVII

4- [2-(hexahydro-4-methyt—1H- 1,4-d iazepin- 1-yI)ethyl]-piperidine
yellow oil (yield = 790/a).
'H NMR (300 MHz, DMSO) 8: 2.89 Cd, 2H); 3.05 (in, 2H); 2.58 (in, 4H); 2.49 (in, 4H); 2.46 Cm, 4H); 2.21 Cs, 3H); 1.66 (in, 2H); 1.64 (in, 2H); 1.28 Cm, 3H); 0.99 (in, 2H).

PREPARATION CXVIII

4-(2-hydroxy- 1, 1-dimethylethyl)- 1-piperidinecarboxylic acid, 1,1-dimethylethyl ester
In operating analogously to preparation LXXXIX, starting with j34~-dimethyl-4-piperidineethanol, the product sought after is obtained as a colourless oil Cyield = 96~/o).
'H NMR (300 MHz, DMSO) 8: 4.41 Ct, 1H) ; 3.98 Cd, 2H) ; 3.13 Cd, 2H) 2.51 (in, 2H) ; 1.50 Cd, 2H) ; 1.38 Cs, 9H); 1.33 Cm, 1H) ; 1.04 (in, 2H);
0.93 Cs, 6H.

PREPARATION CXIX

4-( 1, 1-dimethyl-2-oxoethyl)- 1-piperidinecarboxylic acid, 1, 1-dimethylethyl ester
A solution is prepared of 68 p1(0.77 mM) of oxalyl chloride in 6 ml of anhydrous dichloromethane. 82.5 p1 of dimethylsulphoxide are added at
—700C, and then, after 15 mm, ioo ing (0.39 mM) of the alcohol obtained according to preparation CXVIII in solution in 4m1 of dichloromethane are added. Then, after 5 mm, 270 p1 of triethylamine are added. The mixture is agitated 5 minutes at — 7OGC, and then left to come back to ambient temperature. After addition of 25 ml of ethyl acetate, this organic phase is washed with a 10% sodium bicarbonate solution, dried over magnesium sulphate and concentrated under reduced pressure. The crude product is purified by silica gel chromatography in eluting with the aid of a dichloromethane/ethyl acetate mixture (85/15; v/v). 80 ing of the compound sought after are thus obtained as a colourless oil (yield = 80
Gbo).

'H NMR (250 MHz, DMSO) 8: 9.44 Cs, 1H); 3.96 Cd, 2H); 2.59 (in, 2H); 1.69 Cm, 1H); 1.50 Cm, 2H); 1.38 Cs, 9H); 1.07 (in, 2H) ; 0.93 Cs, 6H).

PREPARATION CXX

4-[2-( 1-azetidinyl)- 1, 1-dimethylethyl]- 1-piperidinecarboxylic acid, 1,1-dimethylethyl ester
In operating analogously to preparation LXXI, starting with the compound obtained according to preparation CXIX and azetidine, the product sought after is obtained as a colourless oil (yield = 650bo).
'H NMR (300 MHz, DMSO) 8: 3.96 Cd, 2H); 3.13 Ct, 4H); 2.51 (in, 2H)
2.16 Cs, 2H); 1.92 Cquin, 2H); 1.55 Cd, 2H); 1.39 Cs, 9H); 1.35 Cm, 1H)
1.05 (in, 2H); 0.70 Cs, 6H).
PREPARATION CXXI
4-[2-(1-azetidinyl)- 1, 1-dimethylethyl]piperidine,
bis(trifl uoroacetate)
520 ing (1.75 mM) of the compound obtained according to preparation CXX are mixed with 3 ml of trifluoroacetic acid and 380 p.1 of anisole in 3 ml of dichloromethane. The mixture is agitated overnight at ambient temperature and then concentrated under reduced pressure. The residue is taken up into 20 ml of toluene and again concentrated under reduced pressure. The crude product is triturated in 4 ml of ethyl ether to give a solid which is separated off by filtration and dried. 683 ing of the compound sought after are thus obtained (yield = 92 %).
M.Pt. = 138-140 0C

PREPARATION CXXII 4-[2-(4-morpholinyl)- 1,1-dimethylethyl]-1-piperidinecarboxylic acid, 1,1-dimethylethyl ester In operating analogously to preparation CXX, starting with morpholine, the product sought after is obtained as a colourless oil (yield = 12%).
'H NMR (300 MHz, DMSO) 8: 3.97 Cd, 2H) ; 3.53 Ct, 4H); 2.57 (in, 2H);
2.41 Ct, 4H) ; 2.10 Cs, 2H) ; 1.60 Cd, 2H) ; 1.38 Cs, 9H) ; 1.29 Cm, 1H)
1.05 (in, 2H); 0.77 Cs, 6H).

PREPARATION CXXIII 4-[2-(4-morpholinyl)-1, 1-dimethylethyl]piperidine, b is(trifl uoroacetate)
In operating analogously to preparation CXXI, starting with the compound obtained according to preparation CXXII, the product sought after is obtained as a pale yellow solid (yield = 69 0bo).

M.Pt. = 158-160 0C

PREPARATION CXXIV

4-[2-(1-piperidinyl)-1,1-dimethylethyl] pyridi ne
A suspension of 70 g (0.58 M) of 4-isopropylpyridine, 250 g (2 M) of piperidine hydrochloride and 85 g of paraformaldehyde in 600 ml of 95% ethanol is held under reflux for 48 hours. The reaction mixture is then concentrated under reduced pressure and the residue is taken up with 650 ml of 3N sodium hydroxide and extracted with thrice 250 ml of ethyl acetate. The combined organic phases are washed with a solution of sodium chloride, dried and concentrated under reduced pressure. The crude product is distilled under a vacuum of 1 mm Hg and the fraction collected between 80 and 125 0C is purified by silica gel chromatography in eluting with the aid of a toluene/isopropanol mixture (9/1 ; v/v). 21.4 g of the compound sought after are thus obtained as a clear yellow oil (yield
= 17%).
'H NMR (300 MHz, CDCI3) ~: 8.49 Cd, 2H); 7.32 Cd, 2H); 2.53 Cs, 2H); 2.20 Ct, 4H); 1.39 (in, 4H); 1.36 Cm, 2H); 1.29 (5, 6H),

PREPARATION CXXV

4-[2-( 1-piperidinyl)-1, 1-dimethylethyl]piperidine

In operating analogously to preparation CVII, starting with the compound obtained according to preparation CXXIV, the product sought after is obtained as a yellow oil (yield = 33 0/a).
'H NMR (300 MHz, DMSO) 8: 2.94 (din, 2H); 2.37 Cm, 6H); 2.03 Cs, 2H); 1.45 Cm, 6H); 1.32 Cm, 2H) ; 1.18 (in, 1H); 1.05 (in, 2H); 0.74 Cs, 6H).
In operating analogously to the preparations CXXIV and CXXV, the two following compounds are obtained

PREPARATION CXXVI
4-[2-(1-pyrrolidinyl)- 1, 1-dimethylethyllpi peridi ne
yellow oil (yield = 72 G/o).
'H NMR C250 MHz, DMSO) 6: 2.97 Cd, 2H); 2.55 (in, 4H); 2.48 (in, 2H); 2.26 Cs, 2H) ; 1.66 (in, 4H) ; 1.62 Cd, 2H) ; 1.29 Cm, 1H) ; 1.03 (in, 2H)
0.77 Cs, 6H).

PREPARATION CXXVII

4-[2-(diethylamino)- 1, 1-dimethylethylJpiperidine

colourless oil(yield = 79 0/a).
'H NMR (300 MHz, DMSO) 8: no 'H NMR

PREPARATION CXXVIII

N,1-dimethyl-N-[1-(phenylmethyl)-4-piperidinyl]-4-
piperidinamine
In operating analogously to preparation LXXI, starting with N-methyl-4-piperidinone and 1-benzyl-4-(methylamino)piperidine, the product sought after is obtained as a yellow oil (yield = 66 Obo).
'H NMR (300 MHz, DM50) 8: 7.28 (in, 5H); 3.41 Cs, 2H); 2.76 Cm, 4H); 2.40 (in, 2H); 2.12 Cs, 3H); 2.10 Cs, 3H); 1.90 Cdt, 2H); 1.81 Cdt, 2H);
1.57 (din, 4H); 1.44 (in, 4H).

PREPARATION CXXIX

N, 1-dimethyl- N-(4-piperidinyl)-4-piperidinamine

A solution is prepared of 980 mg (3.25 mM) of the compound obtained according to preparation CXXVIII in 60 ml of methanol and 150 ing of 10% palladium on carbon are added. The mixture is agitated under an atmosphere of hydrogen, under a pressure of 50 PSI (3.5 bars or 3450 hPa), at ambient temperature for 10 hours. The catalyst is removed by filtration and the filtrate is concentrated under reduced pressure. The

crude product obtained is purified by silica gel chromatography in eluting with the aid of a dichloromethane/methanol/aqueous ammonia mixture (97/3/0.3; v/v/v). The product sought after is obtained as a yellow oil (yield = 29 G/o).
'H NMR (250 MHz, DMSO) 8: 2.94 (d, 2H); 2.76 Cd, 2H) ; 2.43 Cm, 4H); 2.12 Cs, 3H) ; 2.10 Cs, 3H) ; 1.81 Cm, 2H) ; 1.76 Cm, 4H) ; 1.45 (in, 2H) ;
1.30 (in, 2H).

PREPARATION CXXX

4- [2-oxo-2-(4-methyl- 1-piperazinyl)ethyl] pyridine
A solution is prepared of 3 g (17.3 mM) of (4-pyridinyl)acetic acid in 50 ml of tetrahydrofuran (THF) and, at ambient temperature, a solution of 3.4 g (20.7 mM) of carbonyldiimidazole in solution in 50 ml of ThE, is added dropwise. The reaction mixture is agitated for 8 hours, and a solution of 1.73 g (17.3 mM) of N-methylpiperazine in 20 ml of THE is then added. The reaction mixture is heated under reflux of the solvent for 2 hours, and then concentrated under reduced pressure. The residue from evaporation is taken up with 80 ml of 3N sodium hydroxide and extracted with ethyl acetate. The organic phase is dried over magnesium sulphate and concentrated under reduced pressure. The crude product is purified by silica gel chromatography in eluting with the aid of a dichloromethane/methanol mixture (99/1 ; v/v). The product sought after is obtained as a colourless oil (yield = 28 0/a).
'H NMR (250 MHz, DM50) 8 : 8.47 (dd, 2H); 7.23 Cdd, 2H); 3.75 Cs, 2H) 3.46 Ct, 2H); 2.23 Ct, 4H); 2.15 (3H),

PREPARATION CXXXI
4-[2-oxo-2-(4-methyl- 1-piperazinyl)ethyl]piperidine

In operating analogously to preparation CVII, starting with the compound obtained according to preparation CXXX, the product sought after is obtained as a colourless oil (yield = 59 G/~)
'H NMR (250 MHz, DMSO) 8: 3.42 Ct, 4H); 3.28 (in, 2H); 2.87 Cdt, 2H);
2.41 Cdt, 2H); 2.24 Cm, 6H); 2.16 Cs, 3H); 1.71 Cm, 1H); 1.54 (din, 2H); 1.06 (dq, 2H).

In operating analogously to Examples 3 and 4, starting with the acids and amines obtained above (or from amines known from the literature), the following compounds according to the invention are obtained
Exam~Ie 16 N-[2-[2-[4-[3-(1-azetidinyl)propyl]-1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy- N,2, 6-trimethylbenzenesulphonamide, difumarate

Beige solid (yield = 34 G/~4 M.Pt. = 82 GC

ExamDIe 17 N-[2-[2-[4-(1-methyl-3-piperidinyl)- 1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy-N,2,6-trimethylbenzenesul phonamide, difumarate
White solid (yield = 36 0/a). M.Pt. = 60-65 GC

Example 18 N-[2-[2-[4-(1-methyl-4-piperidinyl)-1-piperazinylJ-2-oxo-ethoxy]ethyl]-4-methoxy-N-cyclopropyl-2,6-dimethylbenzenesulphonamide, difumarate White solid (yield = 51 0h). M.Pt. = 185 0C
Example 19
N-[2-[2-[4-[2-( 1-pyrrolidinyl)ethyl]- 1-piperazinyl]-2-oxo-

ethoxy]ethyl]-4-methoxy-N-cyclopropyl-2,6-dimethylbenzenesulphonamide, difumarate
White solid (yield = 420/o). M.Pt. = 141 0C

Example 20 N-[2-l12-[4-[(1-methyl-2-imidazolyl)methyl]- 1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy- N,2, 6-trimethylbenzenesulphonamide, difumarate White solid (yield = 45 0bo). M.Pt. = 60-65 GC

Example 21 N-[2-[2-[4-(1-methyl-4-piperidinyl)- 1-piperazinyl]-2-oxo-ethoxyjethyl ]-4-methoxy- N-ethyl- 2,6-dimethylbenzenesulphonamide, difumarate White solid (yield = 48 0b~). M.Pt. = 206 0C

Example 22 N-112-[2-[4-[3-(dimethylamino)propyl]- 1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy-N-ethyl-2,6-dimethylbenzenesulphonamide, difumarate White solid (yield = 26 G/~). M.Pt. = 600C
Example 23 N-[2-112-[4-(9-methyl-9-azabicyclo[3.3. 1]non-3-yI)- 1-piperazinyl]- 2-oxo-ethoxy]ethyl]-4-methoxy- N, 2,6-trimethylbenzenesulphonamide, fumarate White solid (yield = 73 %). M.Pt. = 96 0C

Example 24 N-[2-[2-[4-[3-(1-pyrrolidinyl)propyl]- 1-piperazinylJ-2-oxo-ethoxy]ethylJ-4-methoxy- N-ethyl-2,6-dimethylbenzenesulphonamide, difumarate White solid (yield = 63 %). M.Pt. = 650C

Example 25 N-[2-[2-[4-[3-(1-pyrrolidinyl)propyl]-1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy-N-cyclopropyl-2,6-dimethylbenzenesulphonamide, difumarate Ecru solid (yield = 61 %). M.PT. = 550C

Example 26 N-[2-[2-[4-(8-cyclopropyl-8-azabicyclo[3.2. 1]oct-3-yI)- 1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy- N,2,6-trimethylbenzenesulphonamide, fumarate White solid (yield = 810/a). M.Pt. = 750C

Example 27
N-[2-[2-114-(8-methyl-8-azabicyclo[3 .2. 1]oct-3-yI)- 1-piperazinyl]-
2-oxo-ethoxy]ethyl]-4-methoxy- N-ethyl-2,6-
dimethylbenzenesulphonamide, difumarate
White solid (yield = 64G/o).
M.Pt. = 185GC

Example 28
N-[2-[2-[4-(8-methyl-8-azabicyclo[3 .2. 1]oct-3-yI)-1-piperazinyl]-
2-oxo-ethoxy]ethyl]-4-methoxy- N-cyclopropyl-2,6-
dimethylbenzenesulphonamide, difumarate
White solid (yield = Sl0/o).
M.Pt. = 1600C

Example 29
N-[2-[2-[4-( 1-cyclopropyl-4-piperidinyl)- 1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy- N,2,6-trimethylbenzenesul phona m ide, difumarate
White solid (yield = 600/o). M.Pt. = 112-1140C

Example 30
N-[2-[2-[4-(8-methyl-8-azabicyclo[3 .2. l]oct-3-yI)- 1-piperazinyl]-
2-oxo-ethoxy]ethyl]-4-methoxy- N-( 1-methylethyl)-2,6-
dimethylbenzenesulphonamide, difu marate
White solid (yield = 600/o).
M.Pt. = 1680C
Example 31 N-[2-[2-[4-(1-ethyl-4-piperidinyl)- 1-piperazinyl]-2-oxo-ethoxyjethyl]-4-methoxy- N, 2,6-trimethylbenzenesulphonam ide, fumarate
Beige solid (yield = 480/a).
'H NMR (250 MHz, DMSO) 8: 6.80 Cs, 2H); 6.53 Cs, 2H); 4.05 Cs, 2H); 3.80 Cs, 3H); 3.53 Ct, 2H); 3.39 (in, 2H); 3.29 Cm, 2H); 3.22 Ct, 2H);
3.12 Cm, 2H); 2.70 Cs, 3H); 2.62 (q, 2H); 2.53 Cs, 6H); 2.48 Cm, 4H);
2.29 (in, 3H); 1.77 (in, 2H); 1.52 Cm, 2H); 1.07 Ct, 2H).

Example 32
N-[2-[2-[4-[ 1-(1, 1-dimethylethyl)-4-piperidinyl]-1- piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy- N,2,6-trimethylbenzene-suiphonamide, difumarate
White solid (yield = 410/a). M.Pt. = 2300C

Example 33 N-[2-[2-[4-[(1-methyl-4-piperidinyl)methyl]- 1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy- N,2,6-trimethyl benzenesuiphonamide, fumarate Yellow solid (yield = 62%). M.Pt. = 500C

Example 34 N-[2-[2-[4-[3-(dimethylamino)propyl]- 1-piperazinyl]-2-oxo-ethoxy]ethyl]-2,6-dichloro—4-methoxy-N-methyl-benzene-suiphonamide, difumarate White solid (yield = 78 0/a).

M.Pt. = 600C

Example 35
N-[2-[2-[4-( 1-methyl-4-piperidinyl)- 1-piperazinyl]-2-oxo-ethoxy]ethyl]-2,6-dichloro—4-methoxy-N-methyl-benzene-suiphonamide, difumarate
White solid (yield = 69 %). M.Pt. = 125GC

Example 36 N-[2-[2-[4-[2-(1-methyl-4-piperidinyl)ethyl]-1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy-N,2,6-trimethylbenzene-suiphonamide, difumarate
Ecru solid (yield = 620/a).
M.Pt. = 900C

Example 37 N-[2-[2-[4-(1-methyl-4-piperidinyl)hexahydro- 1H- 1,4-diazepin-1-yI]- 2-oxo-ethoxy]ethyl]-4-methoxy- N, 2,6-trimethylbenzenesulphonamide, fumarate White solid (yield = 560/a). M.Pt. = 530C

Example 38 N-[2-[2-[4-(1-methyl-4-piperidinyl)- 1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy-N-(1-methylethyl)-2,6-dimethylbenzenesulphonamide, difumarate White solid (yield = 41 a/a). M.Pt. = 170 GC
ExamDie 39
N-[2-[2-[4-[ 1-( 1-methylethyl)-4-piperidinyl]- 1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy- N,2,6-trimethylbenzenesulphonamide, fumarate White solid (yield = 810/a).
M.Pt. = 130 GC

Example 40
N-[2-[2-[4-[3-( 1-piperidinyl)propyl]- 1-piperazinyl]-2-oxo-ethoxyjethyl ]-4-methoxy-N -ethyl- 2,6-dimethylbenzenesulphonamide, difumarate Ecru solid (yield = 600/a).
M.Pt. = 650C

Example 41 N-[2-[2-[4-( 1-methyl-4-piperidinyl)-1-piperazinyl]-2-oxo-ethoxy]ethylJ-2,4-dichloro—6-methoxy-N-methyl-benzene-suiphonamide, difumarate White solid (yield = 46 0/a). M.Pt. = 202 0C

Example 42 N-[2-[2-[4-(1-ethyl-4-piperidinyl)- 1-piperazinylJ-2-oxo-ethoxy]ethyl]-2,6-dichloro—4-methoxy-N-methyl-benzene-suiphonamide, fumarate White solid (yield = 68 %). M.Pt. = 96-98 0C

Example 43 N-[2-[2-[4-((3S)- 1-azabicyclo[2.2.2]oct-3-yI)-1-piperazinyl]-2-
oxo-ethoxy]ethyl]-4-methoxy- N-methyl- 2,6-dichlorobenzenesulphonamide, fumarate White solid (yield = 36 %).
M.Pt. = 75~79 GC

In operating analogously to Example 2, starting with the acids and amines obtained above (or from amines known from the literature), and by using the acid which is adapted for the salification of the purified basic compound, the following compounds according to the invention are obtained:

Example 44 N-[2-[2-[4-(1,2,2,6,6-pentamethyl-4-piperidinyl)- 1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy-N,2,6-trimethylbenzene-suiphonamide, bis(trifluoroacetate)
Colourless oil (yield = 370/a).
'H NMR (300 MHz, CD3CN) 6 : 8.70 Cm broad, 1H) ; 6.75 (5, 2H); 4.10 (5, 2H) ; 3.80 (5, 3H) ; 3.76 Cm, 4H) ; 3.70 Ct, 1H) ; 3.61 Ct, 2H) ; 3.28 (ni, 4H) ; 2.27 Cs, 6H) ; 2.57 Cs, 6H) ; 2.28 (din, 4H) ; 1.47 Cs, 6H) ; 1.38 Cs, 6H).

Example 45
N-[2-112-[4-[3-(4-methyl- 1-piperazinyl)propyl]- 1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy- N, 2,6-trimethylbenzene-suiphonamide, difumarate
White solid (yield = 300/a). M.Pt. = 204 0C
Example 46
N-[2-[2-[4-(8-ethyl-8-azabicyclo[3.2. 1]oct-3-yI)- 1- piperazinyl]-2-z~xo-ethoxy]ethyI]-4-methoxy- N,2,6-trimethyl benzenesuiphonamide, difumarate
White solid (yield = 270/a). M.Pt. = 1320C

Example 47
N -[2- [2-[4- [3-(4-methyl- hexahydro- 1H- 1,4-d iazepin- 1-yI)propyl]- 1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy-N,2,6-trimethylbenzenesu Iphonamide, difumarate
White solid (yield = 450/a). M.Pt. = 169 0C

Example 48 N-[2-[2-[4-(8-(1-methylethyl)-8-azabicyclo[3.2.1]oct-3-yI]-1-piperazinyl]-2-oxo-ethoxy]ethyl] -4- methoxy- N,2,6-trimethylbenzenesulphonamide, difumarate White solid (yield = 350/a). M.Pt. = 1320C

Example 49
N-[2-[2-[4-[3-(4-methyl-hexahydro- 1H- 1,4-diazepin- 1-yI)-3-oxo-propyl]- 1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy-N,2,6-trimethylbenzenesulphonamide, bis(trifluoroacetate)
Colourless oil (yield = 35a/a).
'H NMR (300 MHz, CD3CN) 8: 6.76 Cs, 2H); 4.15 Cs, 2H); 3.84 Cs, 3H); 3.82 Cm, 6H); 3.65 Ct, 2H); 3.62 Cm, 2H); 3.44 Ct, 2H); 3.36 (in, 1OH);
2.90 Ct, 2H); 2.87 Cs, 3H); 2.77 Cs, 3H) ; 2.61 (5, 6H) ; 2.18 Cm, 2H).

Example 50
N -[2-[2-[4- [2-(4-methyl-hexahydro- 1H- 1,4-d iazepi n- 1-yI)ethyl]-
1-pi perazinyl ]-2-oxo-ethoxy]ethyl]-4-methoxy- N, 2,6-
trimethylbenzenesulphonamide, trifumarate
White solid (yield = 8 0/a).
M.Pt. = 176 0C

In operating analogously to Examples 5 and 4, starting with the acids obtained above, the two following compounds according to the invention are obtained

Example 51 N-[2-[2-[4-((3S)-1-azabicyclo[2.2.2]oct-3-yI)-1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy-N-cyclopropyl-2,6-dimethylbenzenesulphonamide, difumarate White solid (yield = 37 %). M.Pt. = 72 0C [aD25] = -11.4 0 Cc = 0.5 ; CH3OH)

Example 52
N-[2-[2-[4-((3S)- 1-azabicyclo[2.2.2]oct-3-yI)- 1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy-N-ethyt- 2,6-dimethylbenzenesulphonamide, difumarate White solid (yield = 32 %).
M.Pt. = 70 0C
= ~ Cc = 0.5; CH3OH)

In operating analogously to Example 1, starting with the acid obtained according to preparation III and 1-[2-(diethylamino)ethyl]piperazine, the following compound according to the invention is obtained

Example 53
N -[2-[2-[4-[2-(diethylamino)ethyl]- 1-piperazinyl]-2-oxo-
ethoxyjethyl ]-4-methoxy- N, 2, 6-trimethylbenzenesu Iphonam ide,
fumarate
White pasty solid (yield = 77 0/a).
'H NMR (300 MHz, CD3CN) 8: 6.74 Cs, 2H); 6.60 Cs, 2H); 4.02 Cs, 2H);
3.80 Cs, 3H); 3.54 Ct, 2H); 3.46 (in, 2H); 3.32 (in, 2H); 3.26 Ct, 2H);
2.96 (in, 6H); 2.74 Cs, 3H); 2.62 Ct, 2H); 2.57 Cs, 6H); 2.41 Cm, 4H);
1.16 Ct, 6H).

PREPARATION CXXXII [2-[methyl(phenylmethyl)amino]ethoxy]acetic acid, 1, 1-dimethylethyl ester
In operating analogously to preparation II, starting with 2-[methyl(phenylmethyl)amino]ethanol, the product sought after is obtained as a colourless oil (yield = 35 0/~~).
'H NMR (250 MHz, DMSO) 8: 7.26 (in, SH); 3.96 Cs, 2H) ; 3.57 Ct, 2H) 3.49 (5, 2H); 2.49 (in, 2H) ; 2.14 Cs, 3H); 1.40 (s, 9H).

PREPARATION CXXXIII
[2-[methyl(phenylmethyl)amino]ethoxy]acetic acid, lithium salt
A solution of ig (3.58 mM) of the compound obtained according to preparation CXXXII in 10 ml of tetrahydrofuran is heated under the reflux of the solvent in the presence of 165 ing of lithia and 3 ml of water, for 8 hours. The reaction mixture is then concentrated under reduced pressure to give the product sought after as a colourless foam (yield = 99 %).

'H NMR (250 MHz, DMSO) 8: 7.26 (in, SH) ; 3.59 Cs, 2H) ; 3.53 Ct, 2H)
3.48 Cs, 2H) ; 2.50 Ct, 2H); 2.12 Cs, 3H).

PREPARATION CX)O(IV
N-methyl- N-[2-[2-[4-(1-methyl-4-piperidinyl)- 1-piperazinyl]-2-oxoethoxy]ethyl]- benzenemethanamine
In operating analogously to Example 5, starting with the salt obtained according to preparation CXXXIII and 1-C 1-methyl-4-piperidinyl)piperazine, the product sought after is obtained as a yellow oil (yield = 24 %).
'H NMR (250 MHz, DM50) 8: 7.26 Cm, SH); 4.09 Cs, 2H); 3.54 Ct, 2H); 3.49 Cs, 2H); 3.37 (in, 4H); 2.78 Cm, 2H); 2.53 Ct, 2H); 2.43 (in, 4H);
2.41 Cs, 3H); 2.11 Cs, 3H); 2.07 (in, 1H); 1.80 Cdt, 2H) ; 1.65 (din, 2H);
1.39 Cdq, 2H).

PREPARATION CXXXV N-methyl-2-[2-[4-(1-methyl-4-piperidinyl)- 1-pi perazinyl]-2-oxoethoxyjethanamine
In operating analogously to preparation XXXV, starting with the compound obtained according to preparation CXXXIV, the product sought after is obtained as a yellow oil (yield = 80 0/a).

'H NMR (300 MHz, DMSO) 8: 4.16 Cs, 2H); 3.55 Ct, 2H); 3.49 (in, lH);
3.39 Cm, 2H); 3.33 (in, 2H); 2.77 Ct, 4H); 2.43 Cm, 2H); 2.38 (s, 3H);
2.16 (in, 2H); 2.12 Cs, 3H); 1.82 Cdt, 2H); 1.67 (din, 2H); 1.38 (dq,
2H).

PREPARATION CXXXVI
2,6-dichloro-4-fluorobenzenesulphonyl chloride
A solution of 4.75g (25 mM) of 2,6-dichloro-4-fluoroaniline in 50 ml of
dichloromethane are added, at —150C, to 4.75 ml of boron trifluoride

etherate. 5 ml of tetrahydrofuran are added to dissolve the precipitate formed, then, slowly, 3.6 ml of t-butyl nitrite in solution in 25 ml of dichloromethane are added. The reaction mixture is agitated 10 minutes at —15 0C and then 20 minutes at +50C. 200 ml of pentane are added, and agitation is maintained at 00C for 30 mm and the precipitate is filtered off. After drying, 7.2 g of the diazonium salt are obtained. This salt is dissolved in 30 ml of acetonitrile and is added, at 10 0C, to a mixture of a solution of sulphur dioxide in 90 ml of acetic acid to which 1.4 g of anhydrous copper (II) chloride and 23 ml of concentrated hydrochloric acid have been added. The reaction mixture is agitated 30 mm at ambient temperature and then concentrated under reduced pressure. The residue from evaporation is taken up into 60 ml of dichloromethane and the insoluble salts are removed by filtration. The filtrate is concentrated under reduced pressure to give 4.71 g of the product sought after as orange crystals (yield = 71 %).
M.Pt. = 570C

Example 54
N-[2-[2-[4-(1-methyl-4-piperidinyl)- 1-piperazinyl]-2-oxo-ethoxyjethyl]- 2,6-dichloro—4-tluoro-N -methyl-benzenesulphonamide
In operating analogously to preparation I, starting with the compounds obtained according to preparations CXXXV and CXXXVI, the product sought after is obtained as a pale yellow oil (yield = 73 0/a).
'H NMR (250 MHz, DMSO) 8: 7.73 Cd, 2H) ; 4.08 (5, 2H); 3.58 Ct, 2H); 3.45 Ct, 2H); 3.40 (in, 2H); 3.30 Cm, 2H); 2.93 Cs, 3H); 2.78 Cm, 2H);
2.41 Cm, 4H); 2.13 (in, 1H) ; 2.11 (5, 3H); 1.81 Ct, 2H); 1.75 Cm, 2H)
1.40 (in, 2H).

Example 55 N-[2-[2-[4-(1-methyl-4-piperidinyl)- 1-piperazinyl]-2-oxo-ethoxy]ethyl]-2,6-dichloro—4-fluoro-N-methyl-benzene-sulphonamide, difumarate In operating analogously to Example 4, starting with the compound
obtained according to Example 54, the product sought after is obtained as a white solid (yield = 76 0/a).
M.Pt. = 152-155 0C

In operating analogously to Examples 54 and 55, starting with benzenesulphonyl chlorides having various substituents, the following compounds according to the invention are obtained

Example 56
N-[2-[2-[4-(1-methyl-4-piperidinyl)- 1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-bromo-2,6-dichloro-N-methyl-benzenesulphonamide
Colourless oil (yield = 37 0/4
'H NMR (300 MHz, DMSO) 8: 7.97 Cs, 2H); 4.07 Cs, 2H); 3.58 Ct, 2H);
3.45 Ct, 2H); 3.43 Cm, 2H); 2.99 Cs, 3H); 2.74 Cm, 2H); 2.42 Cm, 4H);
2.14 Cm, 1H); 2.13 Cs, 3H); 1.81 Ct, 2H); 1.76 Cm, 2H); 1.44 Cm, 2H).

Example 57 N-[2-[2-[4-(1-methyl-4-piperidinyl)- 1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-bromo-2,6-dichloro-N-methyl-benzenesulphonamide, difumarate White solid (yield = 87 0/a).
M.Pt. = 194 0C

Example 58 N-[2-[2-[4-(1-methyl-4-piperidinyl)- 1-piperazinyl]-2-oxo-ethoxy]ethyl]-2,4,6-trichloro-N-methyl-benzenesulphonamide
Colourless oil Cyield = 64%).
'H NMR (300 MHz, DMSO) 8: 7.88 Cs, 2H); 4.08 Cs, 2H); 3.58 Ct, 2H); 3.44 Ct, 2H); 3.38 Cm, 4H); 2.94 Cs, 3H); 2.78 (in, 2H); 2.42 Cm, 4H);
2.17 Cm, 1H) ; 2.11 Cs, 3H) ; 1.81 Ct, 2H) ; 1.76 (in, 2H) ; 1.44 (in, 2H).

Example 59 N-[2-[2-[4-(1-methyl-4-piperidinyl)- 1-piperazinyl]-2-oxo-ethoxy]ethyl ]-2,4,6-trichloro-N-methyl- benzenesul phonam ide, difumarate
White solid (yield = 82 %). M.Pt. = 194 0C

Example 60 N-[2-[2-[4-(1-methyl-4-piperidinyl)-1-piperazinyl]-2-oxo-ethoxy]ethyl ]-2,4-d ichloro-6-methyl- N-methylbenzenesulphonamide
Colourless oil (yield = 61 %).
'H NMR (300 MHz, DMSO) 8: 7.70 Cd, 1H) ; 7.56 Cd, 1H) ; 4.07 Cs, 2H);
3.57 Ct, 2H) ; 3.37 Cm, 2H) ; 3.30 Cs, 4H) ; 2.85 Cs, 3H) ; 2.74 Cm, 2H)
2.62 Cs, 3H) ; 2.42 (in, 4H) ; 2.13 (in, 1H) ; 2.11 Cs, 3H) ; 1.81 Ct, 2H)
1.77 (in, 2H); 1.43 Cm, 2H).

Example 61
N-[2-[2-[4-(1-methyl-4-piperidinyl)- 1-piperazinyl]-2-oxo-ethoxy]ethyl]-2,4-d;chloro-6-methyl-N-methyl-benzenesulphonamide, difumarate

White solid (yield = 87 %). M.Pt. = 190 0C

Example 62
5 N-[2-[2-[4-(1-methyl-4-piperidinyl)- 1-piperazinyl]-2-oxo-ethoxy]ethyl ]-4-methoxy-2,3,6-trimethyl- N-methylbenzenesulphonamide
Colourless oil (yield = 34 %).
'H NMR (250 MHz, DMSO) 8: 6.83 Cs, 1H); 4.03 Cs, 2H); 3.84 Cs, 3H) 10 3.52 Ct, 2H); 3.35 Cm, 2H) ; 3.35 Cm, 2H); 3.18 Ct, 2H); 2.73 Cm, 2H)
2.69 Cs, 3H); 2.57 (5, 3H); 2.42 Cs, 3H); 2.41 Ct, 4H); 2.12 Cs, 3H);
2.10 Cm, 1H); 2.08 Cs, 3H); 1.81 (in, 2H); 1.66 Cm, 2H); 1.38 Cm, 2H).

Example 63
4-methoxy-N,2,3,6-tetra methyl- N-[2-[2-[4-( 1-methyl-4-pi peridinyl)- 1-piperazinyl]-2-oxo-ethoxy]ethyl] benzenesuiphonamide, difumarate
White solid (yield = 71 %). M.Pt. = 180 0C

PREPARATION CXXXVII
4-[[2-[[(4-methoxy-2,6-dimethylphenyl)sulphonyl]
methylamino]ethoxy]acetyl]-1-piperazinecarboxylic acid, 1, 1-dimethylethyl ester
In operating analogously to Example 5, starting with N-Boc-piperazine, the product sought after is obtained which is used in the next step without particular purification.

PREPARATION CXXXVIII

4-methoxy- N,2,6-trimethyl- N- [2- [2-oxo-2-(1-piperazinyl)ethoxy]ethyl]
benzenesulphonamide
In operating analogously to preparation XXIX, starting with the compound obtained following preparation CXXXVII, the product sought after is obtained as a yellow oil (yield = 98 0/a).
'H NMR (250 MHz, DMSO) 8: 6.80 Cs, 2H); 4.04 Cs, 2H); 3.80 Cs, 3H);
3.53 Ct, 2H); 3.30 (in, 2H); 3.23 Ct, 4H); 2.70 Cs, 3H); 2.60 Ct, 4H);
2.53 Cs, 6H).

PREPARATION CXXXIX
4-(3-oxopropyl)-1-piperidinecarboxylic acid, phenylmethyl ester
0.81 ml of dimethylsulphoxide in solution in 10 ml of dichloromethane (DCM) is cooled to —500C and 0.42 ml (4.8 mM) of oxalyl chloride in solution in 1.5 ml of DCM are added. The mixture is agitated for 10 minutes at —60 0C are then, at this temperature, 1.21g (4.4 mM) of the benzyl ester of 4-C3-hydroxypropyl)piperidinecarboxylic acid in solution in 6 ml of DCM are added dropwise. The reaction mixture is agitated for 30 minutes at — 500C and 3 ml of triethylamine are then added dropwise and the temperature is allowed to rise up to ambient temperature in 2 hours. The mixture is hydrolysed on 25 ml of N hydrochloric acid and extracted with DCM. The organic phase is washed with water, dried over magnesium sulphate and concentrated under reduced pressure. The crude product is purified by silica gel chromatography in eluting with the aid of a cyclohexane/ethyl acetate mixture (75/25; v/v). The product sought after is thus obtained as a yellow oil (yield = 830/a).
'H NMR (300 MHz, DMSO) 8: 9.66 Cs, 1H); 7.35 Cm, 5H) ; 5.05 (5, 2H)
3.98 Cm, 2H); 2.75 Cm, 2H); 2.44 (in, 2H); 1.64 (q, 2H); 1.63 (in, 2H);
1.37 (in, 1H); 1.02 Cm, 2H).

PREPARATION CXL
4-[3-[4-[[2-[[(4-methoxy-2,6-dimethylphenyl)sulphonyl]methyl
aminojethoxyjacetyl]- 1-piperazinyl]propyl]-1-piperidinecarboxylic acid, phenylmethyl ester In operating analogously to preparation XXVIII, starting with the compounds obtained following preparations CXXXVIII and CXXXIX, the product sought after is obtained as a colourless oil (yield = 51 %).
'H NMR (300 MHz, DMSO) 8: 7.40 Cm, SH) ; 6.81 (5, 2H); 5.05 (5, 2H)
4.33 Cs, 2H) ; 3.96 (in, 2H) ; 3.79 Cs, 3H) ; 3.55 Ct, 2H) ; 3.37 Cm, 2H)
3.30 Cm, 2H) ; 3.19 Ct, 2H) ; 2.71 Cm, 2H) ; 2.69 Cs, 3H) ; 2.52 Cs, 6H)
2.25 Cm, 6H); 1.65 (in, 2H); 1.42 Cm, 3H); 1.20 Cm, 2H); 1.00 Cm, 2H).

Example 64
4-methoxy-N,2,6-trimethyl-N-[2-[2-oxo-2-[4-[3-(4-piperidinyl)propyl]- 1-piperazinyl]ethoxy]ethyl]benzene-suiphonamide
In operating analogously to preparation )OO(V, starting with the compound obtained following preparation CXL, the product sought after is obtained as a colourless oil (yield = 62 0/a).
'H NMR (250 MHz, DMSO) 8: 6.80 Cs, 2H) ; 4.05 Cs, 2H); 3.80 Cs, 3H); 3.53 Ct, 2H); 3.30 Cm, 4H); 3.19 Ct, 2H); 2.88 Cm, 2H); 2.69 Cs, 3H);
2.50 Cs, 6H); 2.44 (in, 2H); 2.27 Cm, 6H); 1.57 (in, 2H); 1.41 (in, 3H);
1.17 (in, 2H); 0.97 (in, 2H).

Example 65
4-methoxy- N,2,6-trimethyl- N-[2-[2-oxo-2-[4-[3-( 1-methyl-4-piperidinyl)propyl]- 1-piperazinyljethoxyjethyl] benzenesuiphonamide

In operating analogously to preparation XXVIII, starting with the
compound obtained following Example 64, the product sought after is
obtained as a colourless oil (yield = 90 0/a).
'H NMR (250 MHz, DMSO) 8: 6.80 Cs, 2H); 4.05 Cs, 2H); 3.80 Cs, 3H);
3.53 Ct, 2H); 3.38 Cm, 2H); 3.24 Ct, 2H); 3.18 Cm, 2H); 2.72 (in, 2H);
2.69 Cs, 3H); 2.50 Cs, 6H); 2.28 Cm, 6H); 2.11 Cs, 2H); 1.78 Cm, 2H);
1.60 Cm, 2H); 1.45 Cm, 2H); 1.15 (in, 5H).

Examole 66
4-methoxy- N,2,6-trimethyl- N- [2- [2-oxo-2-[4-[3-(1-methyl-4-piperidinyl)propyl]- 1-piperazinyl]ethoxy]ethyl]benzene-suiphonamide, difumarate
In operating analogously to Example 4, starting with the compound obtained following Example 65, the product sought after is obtained as a white solid (yield = 98 %).
M.Pt. = 50 GC

PREPARATION CXLI
4-[4-(phenylmethyl)- 1-piperazinyl]- 1-piperidinecarboxylic acid, 1,1-dimethylethyl ester
In operating analogously to preparation benzylpiperazine and N-Boc-4-piperidinone, obtained as a colourless oil (yield = 60 %). 'H NMR (300 MHz, CDCI3) 8: 7.27 Cm, 5H); 2.61 (in, 11H) ; 1.81 Cm, 2H) ; 1.44 Cs, 9H) ;
PREPARATION CXLII
4-(1-piperazinyl)- 1-piperid inecarboxylic acid, 1, 1-dimethylethyl ester
XXVIII, starting with N-
the product sought after is
4.15 (in, 2H); 3.52 (s, 2H);
1.41 (in, 2H).

A solution is prepared of 15.5 g (43.1 mM) of the compound obtained according to preparation CXLI in 46 ml of ethanol and 3.1 g of palladium hydroxide are added, and then, after rendering the reactor inert, 17.7 g (215 mM) of cyclohexene are added. The reaction mixture is agitated at 50 GC for 6 hours and then cooled and filtered. The filtrate is concentrated under reduced pressure and 10.02 g of the product sought after are obtained as a colourless oil(yield = 86 0/a).
'H NMR (300 MHz, CDCL3) 6: 4.12 (in, 2H); 2.92 Cm, 4H); 2.69 (in, 2H); 2.55 Ct, 4H); 2.36 Cm, 1H); 1.79 (in, 2H); 1.45 Cs, 9H); 1.38 (in, 2H).

PREPARATION CXLIII 4-[4-[[2-[[(4-methoxy-2,6-dimethylphenyl)sulphonyl]-methylaminoethoxy]acetyl ]- 1-piperazinyl]- 1-piperidinecarboxylic acid, 1, 1-dimethylethyl ester In operating analogously to Example 3, starting with the compounds
obtained following preparations III and CXLII, the product sought after is obtained as a colourless oil (yield = 32 0/a).
'H NMR (300 MHz, CD3CN) 8: 6.74 Cs, 2H) ; 4.07 (in, 2H); 4.00 Cs, 2H); 3.80 Cs, 3H); 3.54 Ct, 2H); 3.43 (in, 2H); 3.26 Cm, 4H); 2.74 Cs, 3H);
2.69 (in, 2H); 2.57 Cs, 6H); 2.44 Cm, 4H); 2.34 Cm, 1H); 1.71 Cm, 2H);
1.41 Cs, 9H); 1.29 (in, 2H).

Examnle 67
4-methoxy-N,2,6-trimethyl- N-[2-[2-oxo-2-[4-(4-piperidinyl)- 1-piperazinyl]ethoxy]ethyl]benzenesulphonamide, bis(trifiuo roacetate)
A mixture is prepared of 140 mg (0.24 mM) of the compound obtained according to preparation CXLIII in 1 ml of dichloromethane and 0.7 ml of trifluoroacetic acid. The reaction mixture is agitated at ambient

temperature for 2 hours and then concentrated under reduced pressure.
The residue from evaporation is taken up into 3 ml of water and is freeze-dried. 160 mg of the product sought after are thus obtained as a white solid (yield = 95 %).
M.Pt. = 62 0C

PREPARATION CXLIV
4-(6-nitro-3-pyridinyl)- 1-piperazinecarboxylic acid, 1,1-dimethylethyl ester
A solution is prepared of 1 g (4.9 mM) of 2-nitro-5-bromopyridine and 917 mg (4.9 mM) of N-Boc-piperazine in 10 ml of dimethylformamide and 1.02 g (7.4 mM) of potassium carbonate are added. The reaction mixture is agitated at 1200C for 36 hours and then cooled. 50 ml of water are then added and extraction is carried out with ethyl acetate. The organic phase obtained is washed with water, dried and concentrated under reduced pressure. The crude product is purified by silica gel chromatography in eluting with the aid of a toluene/isopropanol mixture (98/2; v/v). The product sought after is thus obtained as a yellow solid (yield = 330/a).
'H NMR (250 MHz, DMSO) 8: 8.24 Cd, 1H); 8.17 Cd, 1H) ; 7.46 (dd, 1H); 3.50 Cm, 8H); 1.42 (5, 9H).

PREPARATION CXLV
1-(6-nitro-3-pyridinyl)piperazine, bis(trifluoroacetate)
In operating analogously to Example 67, starting with the compound obtained following preparation CXLIV, the product sought after is obtained as a yellow solid (yield = 97 0/a).
M.Pt. = 188-190 GC

PREPARATION CXLVI

4-methoxy- N,2,6-trimethyl- N-[2- [2-oxo-2- [4-(6- nitro-3-pyridinyl)- 1-piperazinyl]ethoxy]ethyl]benzenesulphonamide In operating analogously to Example 3, starting with the compounds obtained following preparations III and CXLV, the product sought after is obtained as a yellow solid (yield = 82 0/a).
M.Pt. = 118-120 0C

Example 68 4-methoxy-N,2,6-trimethyl-N-[2-[2-oxo-2-(4-(6-amino-3-pyridinyl)- 1-piperazinyl]ethoxy]ethyl] benzenesulphonam ide A suspension is prepared of 580 ing (1.11 mM) of the compound obtained following preparation CXLVI in 20 ml of methanol and 58 ing of 10% palladium on carbon are added. The reaction mixture is agitated at ambient temperature for 6 hours under an atmosphere of hydrogen at atmospheric pressure and is then filtered and concentrated under reduced pressure. The crude product is purified by silica gel chromatography in eluting with the aid of a dichloromethane/methanol mixture (97/3; v/v). The product sought after is thus obtained as a yellow pasty solid (yield =
81%).
'H NMR (300 MHz, DMSO) 8: 7.61 Cd, 1H); 7.17 (dd, 1H); 6.80 Cs, 2H); 6.40 (dd, 1H); 5.43 Cs, 2H); 4.11 Cs, 2H); 3.79 Cs, 3H); 3.55 Cm, 4H);
3.44 (in, 2H); 3.24 Ct, 2H); 2.87 (in, 4H); 2.70 Cs, 3H) ; 2.53 (s, 6H).

Example 69
4-methoxy- N,2,6-trimethyl- N.[2- [2-oxo-2-[4-(6-amino-3-pyridinyl)- 1-piperazinyl]ethoxy]ethyl]benzenesutphonamide, fumarate
In operating analogously to Example 4, starting with the compound obtained following Example 68, the product sought after is obtained as a beige solid (yield = 97 %).

M.Pt. = 194-196 0C

Example 70
N-[2-[2-[4-[2-(dimethylamino)-1, 1-dimethylethylj-1-p iperidinyl]-2-oxoethoxy]ethyl]-4-methoxy-N, 2,6-
trimethylbenzenesulphonamide, trifluoroacetate
460 ing of polystyrene resin grafted with a cyclohexylcarbodiimide function are placed in 5 ml of DCM for 20 mm. The solvent is removed by filtration, and 100 mg (0.31 mM) of [2-[[(4-methoxy-2,6-dimethylphenyl)sulphonyl]methylamino]-ethoxy]acetic acid in solution in 3 ml of DCM, 37 ing (0.20 mM) of 4-[2-(dimethylamino)-1,1-
dimethylethyl]piperidine and 2 ing of HOAT(1-hydroxy-7-
azabenzotriazole), are then added. The mixture is agitated for 4 hours and then the resin is separated off by filtration and rinsed with 4 ml of DCM. The combined organic phases are treated with 50 ing of Amberlite IRA 400 resin (0H) for 3 hours, and then with 100 nig of isocyanate grafted polystyrene resin for 1 hour. The resin is removed by filtration and the filtrate is concentrated under reduced pressure. The product obtained is taken up into 0.5 ml of acetonitrile and 6 ml of a 1% solution of trifluoroacetic acid in water are added. The mixture is filtered and freeze-dried. 59 ing of the compound sought after are thus obtained as an amorphous solid (yield = 48 %).
M.Pt. = 60 GC
'H NMR (250 MHz, CD3CN) 8: 6.74 Cs, 2H) ; 4.50 Cm, 1H); 4.06 Cm, 2H);
3.80 Cs, 3H); 3.78 (in, 1H); 3.57 Ct, 2H); 3.31 Ct, 2H); 3.04 (5, 2H);
2.85 Cs, 6H); 2.83 (in, 1H); 2.73 Cs, 3H); 2.56 Cs, 6H); 2.55 Cm, 1H);
1.65 Cm, 2H); 1.45 (in, 1H), 1.20 Cm, 2H); 0.99 Cs, 6H).
Example 71
N-[2-[2-[4-[2-(dimethylamino)-1-hydroxyethyl]-1-piperidinyl]-2-
oxoethoxy]ethyl]-4-methoxy- N, 2,6-
trimethylbenzenesulphonamide, trifluoroacetate
In operating analogously to Example 70, starting with the compound obtained according to preparation LXIX, the product sought after is obtained as a colourless paste (yield = 45 %).
'H NMR (250 MHz, CD3CN) 8: 6.74 Cs, 2H) ; 4.45 (in, 1H) ; 4.05 Cm, 2H); 3.80 Cs, 3H); 3.75 Cm, 2H); 3.59 Ct, 2H); 3.28 Ct, 2H); 3.06 (in, 2H);
2.90 Cm, 1H); 2.84 Cs, 3H); 2.80 Cs, 3H); 2.77 Cs, 3H); 2.56 Cs, 6H);
2.50 (in, 1H); 1.80 (in, 1H); 1.60 (in, 2H); 1.20 (in, 2H).

Example 72
4-methoxy- N, 2,6-trimethyl-N- [2-[2-[4-(4-methyl- 1-pi perazinyl)1-piperidinyl]-2-oxoethoxy]ethyl]benzenesulphonam ide
A suspension is prepared of 350 ing (1.06 mM) of acid obtained according to preparation III in 3 ml of DCM and 243 mg (1.27 mM) of EDGI (1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride) and 173 ing (1.27 mM) of HOAT, are added. The mixture is agitated for 30 mm at ambient temperature, and 232 ing (1.27 mM) of 1-methyl-4-(4-piperidinyl)piperazine are then added. The reaction mixture is agitated for 18 hours at ambient temperature and is then poured over 10 ml of water and extracted with DCM. The organic phase is washed with water, dried and concentrated under reduced pressure. The residue is purified by silica gel chromatography in eluting with the aid of a DCM/methanol mixture (90/10; v/v). 449 ing of the product sought after are thus obtained as a yellow oil (yield = 86 0/a).
'H NMR (300 MHz, CD3CN) 8: 6.74 Cs, 2H); 4.35 Cd, 1H); 4.01 (q, 2H);
3.81 Cs, 3H); 3.69 Cd, 1H); 3.56 Ct, 2H); 3.26 Ct, 2H); 2.89 Ct, 1H);

2.75 Cs, 3H); 2.58 Cs, 6H); 2.40 Cm, 1OH); 2.17 (5, 3H); 1.75 Cm, 2H)
1.27 Cm, 2H).

Example 73
4-methoxy-N,2,6-trimethyl-N- [2-[2-[4-(4-methyl- 1-pi perazinyl)1-piperidinyl]-2-oxoethoxy]ethyl]benzenesulphonamide, fumarate
404 ing (0.814 mM) of the compound obtained according to Example 72 are dissolved in 5 ml of methanol and 95 ing (0.815 mM) of fumaric acid are added. The mixture is agitated for 10 mm and then concentrated under reduced pressure. The residue is taken up into 10 ml of water and the solution is freeze-dried. The salt sought after is thus obtained (474 ing) as a white powder (yield = 95 0/4
M.Pt. = 90 0C

In operating analogously to Examples 72 and 73, starting with the acids and the derivatives of piperidine described above or known from the literature, the following compounds according to the invention are obtained:

Example 74
4-methoxy-N, 2,6-trimethyl-N- [2-[2-[4-( 1-methyl-4-piperidinyl)-
1-piperidinylJ-2-oxoethoxy]ethyl]benzenesulphonamide,
fumarate
White solid (yield = 44 %).
M.Pt. = 88-89 0C

Example 75
N-cyclopropyl-4-methoxy-2,6-dimethyl-N- [2- [2-[4-(4-methyl- 1-
piperazinyl)-1-piperidinyl]-2-oxoethoxy]ethyl]benzene-suiphonamide, difumarate
White solid (yield = 76 0/a). M.Pt. = 148 0C

Example 76
4-methoxy-N,2,6-trimethyl- N-[2- [2-[4- [2-(1- pyrrolidinyl)ethyl]1-piperidinyl]-2-oxoethoxy]ethyl ]benzenesu I phonamide,
fu ma rate
White solid (yield = 87 %).
M.Pt. = 55 0C
'H NMR (300 MHz, CD3CN) 6: 8.50 Cm broad, 1H) ; 6.74 Cs, 2H); 4.38
(in, 1H) ; 4.10 Cd, 2H); 3.80 Cs, 3H); 3.75 (in, 1H); 3.57 (in, 4H) ; 3.27
Ct, 2H); 3.13 Cm, 2H); 2.95 Cm, 3H) ; 2.74 Cs, 3H); 2.57 Cs, 6H); 2.50
(in, 1H) ; 2.06 (in, 4H); 1.65 (in, 5H); 1.07 (in, 2H).

Example 77
4-methoxy-N,2,6-trimethyl- N-[2-[2- [4- [4-( 1-methylethyl)- 1-p iperazinyl]- 1-piperidinyl]-2-oxoethoxy]ethyl]benzene-suiphonamide, fumarate
White solid (yield = 92 %). M.Pt. = 145 0C

Example 78
N-ethyl-4-methoxy-2,6-dimethyl-N-[2-[2-[4- [2-( 1-
pyrrolidinyl)ethyl]- 1-piperidinyl]-2-oxoethoxy]ethyl]benzene-
suiphonamide, fumarate
White solid (yield = 50 0/a)
M.Pt. = 50 0C

Example 79 N-cyclopropyl-4-methoxy-2,6-dimethyl-N-[2-[2-[4-[2-(1-pyrrolidinyl)ethyl]- 1-piperidinyl]- 2-oxoethoxy]ethyl]benzene-suiphonamide, fumarate White solid (yield = 96 %). M.Pt. = 50 0C

Examole 80
N'{2-[2-[4-[2-(hexahydro-4-methyl-1H-1,4-diazepin- 1-yI)ethyU-
1-piperidinyl ]-2-oxoethoxy]ethyl 1-4-methoxy- N,2,6-trimethyl-
benzenesulphonamide, difumarate
White solid (yield = 54 %).
M.Pt. = 60 0C

Example 81 4-methoxy-N,2,6-trimethyl-N-[2-[2-[4-[2-[methyl(1-methylethyl)amino]ethyl]- 1-piperidinyl]-2-oxoethoxy]ethyl ]-benzenesulphonamide, fumarate White solid (yield = 64 %). M.Pt. = 60 0C

Example 82
4-methoxy- N, 2,6-trimethyl- N-[2- [2- [4-[methyl( 1-methyl-4-piperidinyl)amino]-1-piperidinyl]-2-oxoethoxy]ethyl]benzene-suiphonamide, fumarate
White solid (yield = 66 %). M.Pt. = 72 0C
Example 83
4-methoxy- N, 2,6-trimethyl- N-[2- [2- [4-[ 1-( 1-methylethyl)-4-
piperidinyl]- 1-piperidinyl]-2-oxoethoxy]ethyl]benzene-suiphonamide, fumarate
White solid (yield = 84 0/a). M.Pt. = 62-64 0C

Examole 84
4-methoxy-N,2,6-trimethyl- N- [2- [2-(4-( 1-ethyl-4- piperidinyl)- 1-
piperidinyl]-2-oxoethoxy]ethyl]benzenesulphonamide, fumarate
Colourless oil (yield = 35 0/s).
'H NMR (300 MHz, DMSO) 8: 6.80 Cs, 2H) ; 6.51 Cs, 2H) ; 4.32 Cm, lH);
4.06 (q, 2H); 3.80 Cs, 3H) ; 3.67 (in, 1H); 3.53 Cm, 2H); 3.22 (in, 2H)
3.15 Cd, 2H) ; 2.86 Cm, 1H) ; 2.69 Cs, 3H) ; 2.61 (q, 2H) ; 2.53 Cs, 6H)
2.45 (in, 1H); 2.27 Ct, 2H) ; 1.66 (in, 4H) ; 1.30 (in, 3H) ; 1.07 Ct, 3H)
0.96 Cm, 3H).

Examole 85
4-methoxy- N,2, 6-trimethyl- N- [2-[2- [4-( 1-cyclopropyl-4-piperidinyl)- 1-piperidinyl]-2-oxoethoxy]ethyl] benzenesuiphonamide, fumarate
Colourless oil (yield = 63 %).
'H NMR (300 MHz, DMSO) 8: 6.80 Cs, 2H) ; 6.66 Cs, 2H) ; 4.34 Cm, 1H) 4.01 (q, 2H) ; 3.79 (s, 3H) ; 3.66 (in, 1H) ; 3.54 Ct, 2H) ; 3.21 Ct, 2H) ;
2.98 Cd, 2H); 2.82 (in, 1H) ; 2.69 Cs, 3H) ; 2.53 Cs, 6H) ; 2.43 Cm, 1H)
2.10 Ct, 2H); 1.60 (in, 5H) ; 1.23 (in, 1H) ; 1.03 Cm, 5H) ; 0.38 (in, 2H);
0.29 (in, 2H).

Example 86
4-methoxy- N, 2,6-trimethyl- N-[2- [2- [4- [ 2-(4-morpholinyl)ethyl]-
1-piperidinyl]-2-oxoethoxy]ethyl]benzenesulphonamide,
fumarate
White solid (yield = 73 0/o).
M.Pt. = 500C

Example 87 4-methoxy-N,2,6-trimethyl-N-[2-[2-[4-[ 1,1-dimethyl-2-(1-azetidinyl)ethyl]- 1-piperidinyl]-2-oxoethoxy]ethyl ] benzenesuiphonamide, fumarate White solid (yield = 67 %). M.Pt. = 60-62 0C

Example 88 N-ethyl-4-methoxy-2,6-dimethyl- N- [2-112-[4-( 1-methyt-4-piperidinyl)-1-piperidinyl]-2-oxoethoxy]ethyl]benzene-suiphonamide, fumarate White solid (yield = 67 ~/o).
M.Pt. = 650C

Example 89 N-[2-[2-[4-(hexahydro-4-methyl-1H-1,4-diazepin-1-yt)-1-piperidinyl]-2-oxoethoxy]ethyl]-4-methoxy- N,2,6-trimethyl-benzenesulphonamide, fumarate Yellow oil (yield = 61 0/a). 'H NMR (300 MHz, DMSO) 8: 6.80 Cs, 2H); 6.50 Cs, 2H); 4.36 Cm, 1H);
4.11 Cm, 2H); 3.80 Cs, 3H); 3.73 (in, 1H); 3.55 Ct, 2H); 3.24 (t, 2H);
2.87 Cm, 2H); 2.85 (in, 6H); 2.69 Cs, 3H); 2.67 (in, 1H); 2.53 Cs, 6H);
2.46 (5, 3H) ; 2.42 (in, 1H); 1.81 (in, 2H); 1.69 (in, 2H); 1.21 (in, 2H).

Example 90
N-cyclopropyl-4-methoxy- 2,6-dimethyl- N- [2-[2-1i4-( 1- methyl-4-piperidinyl)- 1-piperidinyl]-2-oxoethoxy]ethyl]benzene-suiphonamide, fumarate
White solid (yield = 60 0/a). M.Pt. = 800C

Example 91
2,4-dichioro- N,3-dimethyl- N- [2-[2-[4-(1-methyl-4-pi peridinyl)-1-
piperidi nyl]-2-oxoethoxy]ethyl]benzenesulphonamide, fumarate
White solid (yield = 39 %).
M.Pt. = 86-880C

Example 92
4-methoxy-N,2,6-trimethyl- N-(2-[2-[4-[2-(1-azetidinyl)ethyl]-1-piperidinyl]-2-oxoethoxy]ethyl]benzenesulphonamide, fumarate White solid (yield = 40 0/a).
'H NMR (300 MHz, DMSO) 8: 6.80 Cs, 2H); 6.52 Cs, 2H) ; 4.28 (in, 1H); 4.05 (in, 2H); 3.80 Cs, 3H) ; 3.67 Cm, 1H); 3.57 Cm, 6H) ; 3.20 Ct, ZH)
2.85 (in, 1H) ; 2.78 Ct, 2H) ; 2.69 Cs, 3H) ; 2.53 Cs, 6H) ; 2.49 (in, 1H) ;
2.17 (quin, 2H) ; 1.59 (in, 2H) ; 1.50 (in, 1H) ; 1.30 (in, 2H) ; 0.93 Cm, 2H).

Example 93
2,6-dichloro-4-methoxy- N-methyl- N- [2- [2- [4- [2-
(dimethylamino)ethyl]-1-piperidinyl]-2-oxoethoxy]ethyl]-
benzenesulphonamide, fumarate
White solid (yield = 39 0/o).
M.Pt. = 700C

ExamDIe94
2,6-dichloro-4-methoxy-N-methyl- N-[2-[2-[4-( 1-methyl-4-
piperidinyl)-1-piperidinyl]-2-oxoethoxy]ethyl]benzene-suiphonamide, fumarate
White solid (yield = 70 %). M.Pt. = 670C

Example 95 4-methoxy- N,2,6-trimethyl-N-[2-[2-[4-[(1-pyrrolidinyl)methyl]-
1-piperidinyl]-2-oxoethoxy]ethyl] benzenesulphonamide, fumarate
Colourless oil (yield = 30 ~/o).
'H NMR (250 MHz, DMSO) 8: 6.80 (5, 2H); 6.54 (5, 2H); 4.29 (in, 1H); 4.15 Cm, 2H); 3.80 Cs, 3H); 3.63 Cm, 1H); 3.53 Ct, 2H); 3.22 Ct, 2H);
2.89 (in, 1H); 2.80 (in, 4H); 2.70 Cs, 3H); 2.56 (in, 1H); 2.53 Cs, 6H);
2.51 Cm, 2H); 1.81 Cm, 7H) ; 0.91 (in, 2H).

Example 96
4-methoxy-N,2,6-trimethyl- N-[2-[2-[4-[(4-ethyl- 1-piperazinyl)methyl]- 1-piperidinyl ]-2-oxoethoxy]ethyl]benzene-suiphonamide, fumarate
White solid (yield = 31 %). M.Pt. = 1200C

Example 97 N..cyclopropyl-4-methoxy-2,6-dimethyl-N-[2-[2-[4-[(4-methyl- 1-piperazinyl)methyl]-1-piperidinyl]-2-oxoethoxy]ethyl]benzene-suiphonamide, difumarate White solid (yield = 44 %).
M.Pt. = 1600C

Example 98
N-ethyl-4- methoxy-2,6-d imethyl- N-[2- [2- [4-[(4-methyl- 1-piperazinyl)methyl]-1-piperidinyl]-2-oxoethoxy]ethyl]benzene-suiphonamide, difumarate
White solid (yield = 49 0/a). M.Pt. = 980C

Example 99 N-methyl-4-methoxy-2,6-dichloro- N-[2-[2-[4-[(4-methyl-1-pi perazinyl)methyl]- 1-piperidinyl ]-2-oxoethoxyJethyl]benzene-suiphonamide, difumarate White solid (yield = 50 %). M.Pt. = 1030C

Example 100 4-methoxy-N,2,6-trimethyl-N-[2-[2-[4-[ 1, 1-dimethyl-2-(1-piperidinyl)ethyl]- 1-piperidinyl]-2-oxoethoxy]ethyl] benzenesuiphonamide, trifluoroacetate Colourless oil (yield = 47 %). 'H NMR (300 MHz, CD3CN) 6: 7.50 (in broad, 1H) ; 6.74 Cs, 2H) ; 4.49 (in, 1H) ; 4.01 (q, 2H) ; 3.81 Cs, 3H) ; 3.78 (in, 1H) ; 3.57 Ct, 2H) ; 3.43 (in, 2H); 3.28 Ct, 2H); 3.01 (in, 2H); 2.98 Cs, 2H); 2.90 (in, 1H); 2.74 Cs, 3H) ; 2.63 Cs, 6H) ; 2.45 (in, 1H); 1.85 Cm, 3H); 1.66 Cm, 3H) ; 1.51 (in, 2H) ; 1.19 (in, 3H); 1.00 Cs, 6H).
Example 101
4-methoxy- N,2,6-trimethyl- N-[2-[2-[4-[ 1, 1-dimethyl-2-(1-
pyrrolidinyl)ethyl]- 1-piperidinyl]-2-oxoethoxy]ethyl] benzenesuiphonamide, fumarate
White solid (yield = 61 %). M.Pt. = 50 0C

Example 102
N- [2-[2-[4-[2-(ethylmethylamino)ethyl ]- 1-piperidi nyl ]-2-
oxoethoxy]ethyl]-4-methoxy- N,2,6-trimethylbenzene-
suiphonamide, fumarate
White solid (yield = 46 %).
1H NMR (300 MHz, DMSO) 6: 6.80 (5, 2H); 6.51 (5, 2H); 4.27 (in, 1H);
4.03 (q, 2H); 3.80 Cs, 3H); 3.55 Cm, 1H); 3.24 Ct, 2H); 3.22 Ct, 2H);
2.86 Cm, 1H); 2.70 Cs, 3H); 2.62 (in, 4H); 2.53 Cs, 6H); 2.48 (in, 1H);
2.46 (5, 3H); 1.66 (in, 2H); 1.52 (in, 1H); 1.45 (in, 2H); 1.38 Ct, 3H);
0.97 (in, 2H).

Example 103 N-[2-[2-[4-[2-(diethylamino)ethyl]-1-piperidinyl]-2-oxoethoxy]ethyl]-4-methoxy- N, 2,6-trimethylbenzene-suiphonamide, fumarate White solid (yield = 52 0/a). M.Pt. = 600C

Example 104 4-methoxy-N-(1-methylethyl)-2,6-dimethyl-N-[2-[2-[4-[2-( 1-pyrrolidinyl)ethyl]- 1-piperidinyl]-2-oxoethoxy]ethyl]benzene-suiphonamide, fumarate White solid (yield = 61 %).
M.Pt. = 560C

Example 105 4-methoxy-N,2,6-trimethyl-N-[2-[2-[4-[ 1, 1-dimethyl-2-(4-morpholinyl)ethyl]- 1-piperidinyl]-2-oxoethoxy]ethyl] benzenesuiphonamide, fumarate White paste (yield = 50 0/a). 'H NMR (300 MHz, DMSO) 6: 6.80 Cs, 2H); 6.62 Cs, 2H) ; 4.38 Cm, 1H); 4.04 (q, 2H); 3.79 Cs, 3H); 3.55 (in, 1H); 3.52 (in, 6H); 3.21 (in, 2H);
2.81 Cm, 1H); 2.70 Cs, 3H); 2.53 Cs, 6H); 2.49 (in, 4H); 2.47 Cm, 1H);
2.09 Cs, 2H); 1.60 (in, 2H); 1.43 Cm, 1H); 1.10 (in, 2H) ; 0.76 Cs, 6H).

Example 106
N-[2-[2-[4-[2-(hexahydro-4-methyl- 1H-1,4-diazepin-1-yI)ethyl]-
1-piperidinylj-2-oxoethoxy]ethylj-4-methoxy- N, 2,6-
trimethylbenzenesulphonamide, difumarate
White solid (yield = 36 %).
M.Pt. = 125 0C

Example 107
N-[2-[2-[4-[(hexahyd ro-4-methyl- 1H- 1,4-diazepi n-1-yI)methyt]-
1-piperidinyl]-2-oxoethoxy]ethyl]-4-methoxy- N,2,6-
trimethylbenzenesu Iphonamide, difuma rate
White solid (yield = 31 %).
M.Pt. = 100~102GC

Example 108 4-methoxy-N-[2-[2-[4-[2-(1-methyl-4-piperidinyl)ethylJ-1-piperidinyl]-2-oxoethoxy]ethyl]- N,2,6-trimethylbenzenesulphonamide, fumarate
White solid (yield = 240/a). M.Pt. = 700C

In operating analogously to Example 70, starting with the acids and the derivatives of piperidine described above or known from the literature, the following compounds according to the invention are obtained

Example 109 4-methoxy-N-[2-[2-[4-[2-(1-piperidinyl)ethyl]- 1-piperidinyl]-2-oxoethoxyjethyl]- N,2,6-trimethylbenzenesulphonamide, fumarate
White solid (yield = 690/a). M.Pt. = 500C

Example 110 4-methoxy-N-[2-[2-[4-[2-(1-pyrrolidinyl)ethyl]- 1-piperidinyl]-2-oxoethoxyjethyl]- N-methyl-2-trifluoromethyl-benzenesulphonamide, trifluoroacetate Colourless oil (yield = 99%). 'H NMR (300 MHz, CD3CN) 6: 8.20 (in broad, 1H); 7.95 Cd, 1H); 7.41 Cd, 1H); 7.25 (dd, 1H); 4.43 Cm, 1H); 4.10 (q, 2H) ; 3.91 Cs, 3H); 3.63 (in, 1H); 3.63 (in, 4H); 3.43 Ct, 2H); 3.13 (in, 2H); 2.96 (in, 2H); 2.90 Cs, 3H); 2.60 Ct, 1H); 2.06 Cm, 6H); 1.71 Cm, 4H); 1.60 Cm, 2H).

Example 111
4-methoxy- N- [2-[2- [4- [2-( 1-methyl-4-pi perazinyl)-2-oxoethyl]-
1-piperidinyl]-2-oxoethoxy]ethyl]- N,2,6-
trimethylbenzenesu Iphonamide, fumarate
White solid Cyield = 33%).
M.Pt. = 600C
Example 112
4-methoxy-N,2,6-trimethyl-N-[2-[2-[4-[ 1,1-dimethyl-2-
(diethylamino)ethyl]- 1-piperidinyl]-2-oxoethoxy]ethyl] benzenesuiphonamide, trifluoroacetate
Colourless oil (yield = 26 %).
'H NMR (300 MHz, DMSO) 6 : 8.12 Cm broad, 1H); 6.81 Cs, 2H) ; 4.40 Cm,
1H); 4.09 (q, 2H); 3.80 Cs, 3H); 3.78 (in, 1H); 3.54 Ct, 2H); 3.24 Ct,
2H); 3.15 Cm, 4H); 2.97 Cd, 2H); 2.84 Ct, 1H); 2.70 Cs, 3H); 2.53 Cs,
6H); 2.41 Cm, 1H); 1.64 (in, 2H); 1.42 (in, 1H); 1.25 Cm, 2H); 1.22 Ct,
6H); 0.96 Cs, 6H).

Example 113
4-methoxy- N,2,6-trimethyl- N- [2- [2- [4-(dimethylamino)methyl]-
1-piperidinyl]-2-oxoethoxy]ethyl]benzenesulphonamide,
fumarate
White solid (yield = 63 %).
M.Pt. = 650C

Example 114
4-methoxy-N,2,6-trimethyl-N- [2- [2- [4-[( 1-azetidinyl)methyl]-1-
piperidinyl]-2-oxoethoxy]ethyl]benzenesul phonamide, fumarate
White solid (yield = 60 %).
M.Pt. = 750C

Example 115
N,2,4,6-tetramethyl- N-[2-[2-[4-( 1-methyl-4-pi peridinyl)- 1-piperidinyl]-2-oxoethoxy]ethyl] benzenesu Iphonamide, trifluoroacetate
Colourless oil Cyield = 97 %).
'H NMR (250 MHz, CD3CN) 6: 9.40 Cm broad, 1H); 6.97 Cs, 2H); 4.98
(in, 1H); 4.09 (q, 2H); 3.71 Cm, 1H); 3.57 Ct, 2H); 3.45 Cd, 2H); 3.28
Ct, 2H); 2.85 (in, 1H); 2.80 (in, 2H); 2.77 (5, 3H); 2.72 Cd, 3H); 2.56
Cs, 6H); 2.45 (in, 1H); 2.28 Cs, 3H) ; 1.92 Cm, 2H); 1.71 (in, 2H); 1.50
(in, 2H); 1.34 (in, 2H); 1.09 (in, 2H).

Example 116
N-methyl- N-[2-[2-[4-( 1-methyl-4-piperidinyl)- 1-piperidinyl]-2-oxoethoxy]ethyl]-2-trifluoromethyl-benzenesulphonamide, trifluoroacetate
Colourless oil (yield = 98 %).
'H NMR (300 MHz, CD3CN) 6: 8.50 (in broad, 1H); 7.97 (in, 2H); 7.77 (in, 2H) ; 4.48 (in, 1H); 4.13 (q, 2H); 3.80 Cm, 1H); 3.64 Cm, 2H); 3.49 Ct, 2H); 3.42 Cm, 2H); 2.96 Cs, 3H); 2.90 (in, 1H); 2.78 (in, 2H); 2.72 Cd, 3H); 2.50 (in, 1H); 1.93 Cm, 2H); 1.73 (in, 2H); 1.38 (in, 4H); 1.36 (in, 2H).

Example 117
4-methoxy- N-methyl- N-[2- [2-[4-( 1-methyl-4-piperidi nyl)- 1-
piperidinyl]-2-oxoethoxy]ethyl]-2-trifluoromethyl-
benzenesulphonamide, trifluoroacetate
Colourless oil (yield = 95 %).
'H NMR (300 MHz, CD3CN) 6: 8.41 Cm broad, 1H); 7.96 Cd, 1H); 7.40
Cd, 1H); 7.25 (dd, 1H); 4.45 (in, 1H); 4.10 Cq, 2H); 3.91 Cs, 3H); 3.80
(in, 1H); 3.61 Ct, 2H); 3.42 (in, 4H); 2.90 Cs, 3H); 2.89 (in, 1H); 2.79
Cm, 2H); 2.73 Cd, 3H); 2.50 (in, 1H); 1.92 Cm, 2H); 1.73 Cm, 2H); 1.37
(in, 4H); 1.07 Cm, 2H).

Example 118 N,2,4,6-tetramethyl-N-[2-[2-[4-[2-(1-pyrrolidinyl)ethyl]- 1-p1 peridinyl]-2-oxoethoxy]ethyl] benzenesulphonamide, trifluoroacetate
Colourless oil (yield = 99 %).
'H NMR (300 MHz, CD3CN) 6: 8.40 (in broad, 1H) ; 7.03 Cs, 2H) ; 4.37 Cm, 1H) ; 4.02 (q, 2H); 3.75 Cm, 1H) ; 3.58 (in, 4H) ; 3.31 Ct, 2H) ; 3.10 (in, 2H) ; 2.91 (in, 3H); 2.75 Cs, 3H) ; 2.56 Cs, 6H); 2.54 Cm, 1H) ; 2.29 Cs, 3H) ; 2.10 (in, 4H); 1.61 (in, 5H); 1.10 (in, 2H).

Example 119
2, 6-dichloro-4-methoxy-N-methyl- N-[2-[2-[4-( 1-methyl-4-pi perazinyl)- 1-piperidinyl]-2-oxoethoxy]ethyl] benzenesuiphonamide, difumarate
White solid (yield = 76 0/a). M.Pt. = 176 0C

Example 120
4-methoxy- N,2,6-trimethyl- N- [2- [2-[4- [2-(dimethylamino)ethyl]- 1-piperidinyl]-2-oxoethoxy]-ethyl] benzenesulphonamide, fumarate
A solution is prepared of 200 ing (0.6 mM) of acid obtained according to preparation III in 2 ml of chloroform and 0.2 ml of dimethylformamide and 0.12 ml of oxalyl chloride are added at ambient temperature. The mixture is agitated for 1 hour at ambient temperature and concentrated under reduced pressure. The residue is taken up into 3 ml of chloroform, and 103 ing (0.66 mM) of N,N-dimethyl-4-piperidineethanamine and 92 p1 of triethylamine are added, and agitation is carried out for 2 hours at ambient temperature. The reaction mixture is concentrated under reduced

pressure and the residue is purified by silica gel chromatography in eluting with the aid of a dichloromethane/methanol/aqueous ammonia mixture (95/5/0.5; v/v/v). 247 ing of amide are obtained as an oil which is salified with fumaric acid according to the method applied in Example 73 to obtain the salt as a white solid (yield = 83 0/a).
M.Pt. = 550C

Example 121
4-methoxy- N,2,6-trimethyl-N- [2-[2-[4-(4-cyclopropyl- 1-piperazinyl)- 1-piperidinyl]-2-oxoethoxy]ethyl]benzene-suiphonamide, fumarate
2.2 g of tetrafluorophenol resin are placed in suspension in 10 ml of dimethylformamide and 40 ml of dichloromethane and 50 nig of 4-dimethylaminopyridine, 0.66 ml of diisopropylcarbodiimide and ig (3.1 mM) of acid obtained according to preparation III, are added. The mixture is agitated at ambient temperature for 16 hours, and then the resin is separated off by filtration and reallowed to react in 40 ml of dichloromethane with 0.5 g (2.39 mM) of 1-cyclopropyl-4-(4-piperidinyl)piperazine, for 2 hours at ambient temperature. The reaction mixture is filtered and the filtrate is concentrated under reduced pressure. The crude product obtained is purified by silica gel chromatography in eluting with the aid of a dichloromethane/methanol mixture (99/1; v/v). 700 ing of amide are obtained as an oil which is salified with fumaric acid according to the method applied in Example 73 to obtain the salt as a white solid (yield = 49 %).
M.Pt. = 800C

In operating analogously to Example 121, starting with the amines obtained according to preparations LXXXVIII and LXXIV, the following compounds according to the invention are obtained:
Eample 122
4-methoxy-N,2,6-trimethyl- N- [2-[2-[4-[4-( 1, 1-d imethylethyl)- 1-p1 perazinyl]- 1-piperidinyl]-2-oxoethoxy]xethyl]benzene-suiphonamide, difumarate
White solid (yield = 48 %) M.Pt. = 170 GC

Example 123
4-methoxy-N,2,6-trimethyl- N- [2-112-[4-[(4-methyl- 1-
piperazinyl)methyl ]- 1-piperidinyl ]-2-oxoethoxy]ethyl]benzene-
suiphonamide, difumarate
White solid (yield = 39 %)
M.Pt. = 168 0C

In operating analogously to Examples 70 and 73, starting with the amine obtained according to preparation CVII, the following compound according to the invention is obtained

Example 124
4-methoxy-N,2,6-trimethyl- N- [2- [2-[4- [2-(4-methyl- 1-piperazinyl)ethyl]- 1-piperidinyl]- 2-oxoethoxy]ethyl]benzene-suiphonamide, difumarate
White solid (yield = 59 %) M.Pt. = 178-1790C

PREPARATION CXLVII
4-methoxy- N,2,6-trimethyl- N- [2- [2-[4-(3-hyd roxypropyl)- 1-piperidinyl]-2-oxoethoxy]ethyl]benzenesulphonamide

In operating analogously to Example 72, starting with 3-(4-
piperidinyl)propanol, the product sought after is obtained as a colourless
oil (yield = 79 %).
'H NMR (300 MHz, DMSO) 6 : 6.80 Cs, 2H); 4.34 Ct, 1H); 4.28 (din, 1H);
4.03 (in, 2H); 3.79 Cs, 3H); 3.64 (din, 1H); 3.53 Ct, 2H); 3.37 Cd, 2H);
3.21 Ct, 2H); 2.86 Ct, 1H); 2.70 Cs, 3H); 2.53 Cs, 6H); 2.45 (in, 1H)
1.63 Cd, 2H); 1.40 (in, 3H); 1.19 (in, 2H); 0.93 (in, 2H).

PREPARATION CXLVIII
4-methoxy- N,2,6-trimethyl- N-[2- [2- [4-[3-II(4-
methylphenyl)sulphonyl]oxy]propyl]- 1-piperidinyl]-2-oxoethoxy]ethyl]-benzenesulphonam ide
A solution is prepared of 6.8 g (14.9 mM) of the compound obtained according to preparation CXLVII in 50 ml of dichloromethane and, at ambient temperature, 3.4 ml (24.6 mM) of triethylamine, and then 4.68 g (24.6 mM) of tosyl chloride and 142 mg (1.5 mM) of trimethylamine hydrochloride, are added. The mixture is agitated for 4 hours under reflux of the solvent and then cooled and hydrolysed on 50 ml of water. The organic phase is washed with water, dried over magnesium sulphate and concentrated under reduced pressure. The residue is purified by silica gel chromatography in eluting with the aid of an ethyl acetate/toluene mixture (8/2; v/v). 5.6 g of the compound sought after are obtained as a colourless oil (yield = 62 %).
'H NMR (300 MHz, DMSO) 6: 7.79 (dd, 2H) ; 7.48 Cd, 2H); 6.80 Cs, 2H); 4.26 Cm, 1H) ; 4.00 (in,, 3H); 3.79 Cs, 3H) ; 3.62 Ct, 2H); 3.51 (in, 2H)
3.23 (in, 2H); 2.85 (in, 1H); 2.70 Cs, 3H) ; 2.53 (5, 6H) ; 2.45 (in, 1H)
2.41 (s, 3H); 1.55 (in, 3H); 1.29 Cm, 2H); 1.13 (in, 2H) ; 0.89 Cm, 2H).

Example 125 4-methoxy-N,2,6-trimethyl- N-[2-[2- [4-[3-(4-morpholinyl)-propyl]- 1-piperidinyl]-2-oxoethoxy]ethyl]benzenesulphonamide A solution is prepared of 400 mg (0.65 mM) of the compound obtained according to preparation CXLVIII in 8 ml of dimethylformamide and, at ambient temperature, 90 nig (0.65 mM) of potassium carbonate, and then 95 p1 (1 mM) of morpholine, are added. The mixture is agitated for 16 hours at 600C and then cooled, hydrolysed on 20 ml of water and extracted with ethyl acetate. The organic phase is washed with water, dried over magnesium sulphate and concentrated under reduced pressure. The residue is purified by silica gel chromatography in eluting with the aid of a dichloromethane/methanol mixture (98/2; v/v). 150 mg of the compound sought after are obtained as a colourless oil (yield = 44 0A,).
'H NMR (300 MHz, DMSO) 6: 6.80 Cs, 2H); 4.27 (in, 1H); 4.05 (q, 2H); 3.79 Cs, 3H); 3.70 (in, 1H); 3.54 (in, 6H); 3.21 Ct, 2H); 2.85 (in, 1H);
2.70 Cs, 3H); 2.53 (5, 6K); 2.42 (in, 1H); 2.31 (in, 4H); 2.22 Ct, 2H);
1.65 Cm, 2H); 1.41 (in, 3H); 1.36 (in, 2H); 0.96 (in, 2H).

Example 126 4-methoxy-N,2,6-trimethyl-N-[2-[2-[4-[3-(4-morpholinyl)-propyl]-1-piperidinyl]-2-oxoethoxy]ethyl]benzenesulphonamide, fumarate
In operating analogously to Example 73, starting with the compound obtained according to Example 125, the product sought after is obtained as a white solid (yield = 99 0/a).
M.Pt. = 500C

In operating analogously to Examples 125 and 126, starting with various amines, the following compounds according to the invention are obtained:

Example 127
4-methoxy-N,2,6-trimethyl- N-[2-[2-[4-[3-(1-pyrrolidinyl)propyl]- 1-piperidinyl ]-2-oxoethoxy]ethyl]-benzenesulphonamide
Colourless oil (yield = 53%).
'H NMR (300 MHz, DMSO) 6: 6.80 Cs, 2H); 4.30 Cm, 1K); 4.06 (q, 2K); 3.80 Cs, 3K); 3.68 Cm, 1H); 3.53 Ct, 2K); 3.20 Ct, 2K); 2.90 (in, 1K);
2.71 Cs, 3H); 2.61 Cm, 6H); 2.53 Cs, 6H); 2.48 (in, 1K); 1.75 Cs, 4H);
1.62 (in, 2K); 1.48 Cm, 2H); 1.42 Cm, 1H); 1.21 (in, 2H); 0.92 Cm, 2H).

Example 128 4-methoxy-N,2,6-trimethyl-N-[2-[2-[4-[3-(1-pyrrolidinyl)propyl]- 1-piperidinyl]-2-oxoethoxy]ethyl]benzene-suiphonamide, fumarate White solid (yield = 92%). M.Pt. = 500C

Examnle 129
4-methoxy-N,2,6-trimethyl- N- [2- [2- [4- [3-(hexahyd ro-4-methyl-
1H- 1,4-diazepin-1-yI)propyl]- 1-piperidinyl]-2-oxoethoxy]ethyl]benzene-sulphonamide
Colourless oil (yield = 27%).
'H NMR (300 MHz, DMSO) 6: 6.80 Cs, 2K); 4.29 Cm, 1H); 4.05 (q, 2H); 3.79 (5, 3H); 3.65 (in, 1H); 3.50 Ct, 2H); 3.23 Ct, 2H); 2.85 (in, 1K);
2.69 Cs, 3K); 2.57 Cm, 8H); 2.46 Ct, 2K); 2.34 Cs, 3H); 1.65 (in, 4H);
1.37 (in, 3K); 1.17 (in, 2H) ; 0.95 Cm, 2K).
Example 130
4-methoxy- N,2,6-trimethyl- N- [2- [2- [4-[3-(hexahydro-4-methyt-
1H- 1,4-diazepin-1-yI)propyl]-1-piperidinyl]-2-
oxoethoxy]ethyl]benzene-sulphonamide, difumarate
White solid (yield = 4l0/a).
M.Pt. = 1740C

Example 131
4-methoxy-N,2,6-trimethyl- N-[2- [2- [4-[3-(4-methyl- 1-piperazinyl)propyl]- 1-piperidinyl]-2-oxoethoxy]ethyl]benzene-suiphonamide
Colourless oil (yield = 43%).
'H NMR (300 MHz, DMSO) 6: 6.80 Cs, 2H); 4.27 (in, 1H) ; 4.03 (q, 2K); 3.79 Cs, 3K); 3.65 Cm, 1K) ; 3.52 Ct, 2K) ; 3.23 Ct, 2K) ; 2.85 (in, 1K) ;
2.69 Cs, 3K); 2.53 Cs, 6K) ; 2.48 Cm, 1K) ; 2.29 Cm, BK) ; 2.23 Ct, 2K)
2.12 Cs, 3K); 1.63 Cm, 2K); 1.38 Cm, 3K); 1.17 (in, 2K) ; 0.95 Cm, 2K).

Example 132
4-methoxy- N,2,6-trimethyl- N-[2- [2- [4- [3-(4-methyl- 1-piperazinyl)propyl]- 1- piperidinyl]-2-oxoethoxy]ethyl] benzenesuiphonamide, difumarate
White solid (yield = 89%). M.Pt. = 1740C

Example 133
4-methoxy-N,2,6-trimethyl-N-[2-[2- [4-[3-(1-azetidinyl)propyl]-
1-piperidinyl]-2-oxoethoxylethyl]benzenesulphonamide
Colourless oil (yield = 23%).

'H NMR (300 MHz, DMSO) 6: 6.80 Cs, 2H); 4.26 (in, 1K); 4.02 (q, 2K);
3.80 Cs, 3K); 3.68 Cm, 1K); 3.54 Ct, 2K); 3.21 Ct, 2K); 3.03 Ct, 4K);
2.85 (in, 1K); 2.70 Cs, 3K); 2.53 Cs, 6K); 2.48 (in, 2K); 2.47 (in, 1H);
2.25 Ct, 2K); 1.91 (quin, 2K); 1.60 Cm, 2K); 1.40 Cm, 1K); 1.18 (in,
4K) ; 0.89 Cm, 2K).

Example 134
4-methoxy-N,2,6-trimethyl- N-[2-[2-[4-[3-(1-azetidinyl)propyl]-
1-piperidinylj-2-oxoethoxy]ethylJbenzenesulphonamide,
fuma rate
White solid (yield = 93%).
M.Pt. = 650C

Example 135 4-methoxy-N,2,6-trimethyl-N-[2-[2-[4-[3-(dimethylamino)-propyl]-1-piperidinyl]-2-oxoethoxy]ethyl]benzenesulphonamide
Colourless oil (yield = 23%).
'K NMR (250 MHz, DMSO) 6: 6.80 Cs, 2K) ; 4.30 (in, 1K) ; 4.02 (q, 2K); 3.79 (5, 3K) ; 3.65 Cm, 1K) ; 3.52 Ct, 2K) ; 3.21 Ct, 2K) ; 2.85 Cm, 1K) ;
2.70 (s, 3K) ; 2.53 Cs, 6K) ; 2.44 (in, 1K) ; 2.14 Ct, 2K) ; 2.09 Cs, 6K) ;
1.60 (in, 2K); 1.38 Cm, 3K); 1.17 Cm, 2K); 0.91 Cm, 2K).

Example 136
4-methoxy-N,2,6-trimethyl- N-[2- [2-[4- [3-(dimethyla mino)propyl]- 1-piperidinyl]-2-oxoethoxy]ethyl]-benzenesulphonamide, fumarate
White solid (yield = 990/a). M.Pt. = 55GC

PREPARATION CIL
1'-[[2-[[(4-methoxy-2,6-dimethyiphenyl)suiphonyl]methyl-
amino]ethoxy]acetyl] [4,4'-bipiperidine]- 1-carboxytic acid, 1,1-dimethylethyl ester
In operating analogously to Example 72, starting with the compound obtained according to preparation LXXXIX, the product sought after is obtained as a colourless oil (yield = 88 0/o).
'H NMR (250 MHz, DMSO) 8: 6.80 Cs, 2H); 4.39 Cm, 1K); 3.98 Cm, 4K); 3.79 Cs, 3H); 3.70 Cm, 1K); 3.53 Ct, 2K); 3.20 Ct, 2K); 2.85 Cm, 1K);
2.69 Cs, 3K); 2.61 (in, 2K); 2.53 Cs, 6K); 2.43 (in, 1K); 1.62 Cm, 4K);
1.38 Cs, 9H); 1.23 (in, 2K); 1.01 Cm, 4K).

Example 137 N-[2-(2-[4,4'-bipiperidin]- 1-yI-2-oxoethoxy)ethyl]-4-methoxy-N,2,6-trimethyl-benzenesulphonam ide, trifluoroacetate In operating analogously to preparation CXXI, starting with the compound obtained according to preparation CIL, the product sought after is obtained as a white foam (yield = 99 0/a). 'H NMR (250 MHz, CD3CN) 8: 7.00 (in broad, 1K); 6.74 Cs, 2K); 4.48 (in, 1K) ; 4.05 (q, 2K); 3.80 Cs, 3K) ; 3.75 (in, 1K) ; 3.57 Ct, 2K); 3.35 (in, 2K) ; 3.30 Ct, 2K), 2.92 (in, 3K) ; 2.74 Cs, 3K); 2.57 Cs, 6K) ; 2.48 (in, 1K) ; 1.89 (in, 2K); 1.71 (in, 2K) ; 1.43 (in, 4K); 1.10 (in, 2K).

PREPARATION CL [2-[1-[[2-[[(4-methoxy-2,6-dimethylphenyl)sulphonyl]methyl-amino]ethoxy]acetyl]-4-piperidinyl]ethyl]methyl-carbamic acid, 1, 1-dimethylethyl ester In operating analogously to Example 72, starting with the compound obtained according to preparation CXIV, the product sought after is obtained as a colourless oil (yield = 82 0/a).
'H NMR (250 MHz, DMSO) 6: 6.80 Cs, 2H); 4.32 (in, 1H); 4.04 (q, 2K);
3.80 (s, 3K); 3.69 Cm, 1H); 3.56 Ct, 2H); 3.21 Ct, 2K); 3.19 Cm, 2H)
2.85 Cm, 1K); 2.74 (5, 3H); 2.70 Cs, 3K); 2.53 Cs, 6K); 2.46 (in, 1K)
1.65 Cm, 2K); 1.38 Cs, 9K); 1.34 (in, 3K); 1.01 Cm, 2K).

Example 138
4-methoxy-N,2,6-trimethyl-N-[2- [2- [4-[2-(methylam ino)ethyl]1-piperidinyl]-2-oxoethoxy]ethylJbenzenesulphonam ide
In operating analogously to preparation XXIX, starting with the compound obtained according to preparation CL, the product sought after is obtained as a colourless oil (yield = 99 0/c,).
'H NMR (250 MHz, DMSO) 8: 6.80 Cs, 2K); 4.25 Cm, 1K) ; 4.05 (q, 2K); 3.80 (5, 3K) ; 3.65 (in, 1K) ; 3.55 Ct, 2K) ; 3.19 Ct, 2K) ; 2.85 (in, 1K)
2.70 Cs, 3K) ; 2.51 Cs, 6K) ; 2.48 (in, 3K) ; 2.24 Cs, 3K) ; 1.59 Cm, 2K) ;
1.52 Cm, 1K); 1.34 (in, 2K) ; 0.92 Cm, 2K).

Example 139
4-methoxy-N,2,6-trimethyl-N-[2-[2- [4- [2-(methylam ino)ethyt]1-piperidinyl]-2-oxoethoxy]ethyl]benzenesulphonam ide, fu ma rate
In operating analogously to Example 73, starting with the compound obtained according to Example 138, the product sought after is obtained as a white solid (yield = 99 0/a).
M.Pt. = 500C

PREPARATION CLI [1-[[ 2-[ [(4-methoxy-2,6-dimethylphenyl)sulphonyl]methyl-amino]ethoxy]acetyl]-4-piperidinyl]carbamic acid, 1,1-dimethylethyl ester
In operating analogously to Example 72, starting with t-butyl (4-piperidinyl)carbamate, the product sought after is obtained as a colourless oil (yield = 66 0/a).
'H NMR (250 MHz, DMSO) 8: 6.80 Cs, 2K); 4.07 Cm, 1H) ; 4.04 (in, 2H); 3.80 Cs, 3K) ; 3.52 Cm, 4K) ; 3.22 Ct, 2K) ; 2.95 Cm, 1K) ; 2.70 (5, 3H)
2.67 (in, 1K); 2.53 Cs, 6K); 1.72 (in, 2K); 1.38 (5, 9K); 1.26 Cm, 2K).

Examole 140 N-[2-[2-(4-amino- 1-piperidinyl)-2-oxoethoxy]ethyl]-4-methoxy-N,2,6-trimethyl- benzenesu Iphonamide In operating analogously to preparation XXIX, starting with the compound obtained according to preparation CL, the product sought after is obtained as a yellow oil (yield = 86 0/a). 'H NMR (300 MHz, DMSO) 8: 6.80 Cs, 2K); 4.13 Cm, 1K) ; 4.05 (in, 2K);
3.80 Cs, 3K) ; 3.60 (in, 1K) ; 3.55 Ct, 2K) ; 3.46 Cm broad, 2K) ; 3.22 Ct, 2K) ; 2.89 Cm, 2K); 2.70 (5, 3K); 2.67 Cm, 1K) ; 2.53 Cs, 6K) ; 1.74 (in, 2K); 1.51 Cm, 2K).

Example 141
4-methoxy-N,2,6-trimethyl- N-[2-[2-[4-[(8-methyl-8-azabicyclo[3.2..1]oct-3-yI)amino]-1-piperidinyl]-2-oxoethoxy]ethyl]benzenesulphonamide
In operating analogously to preparation LXXI, starting with the compound obtained according to Example 140, the product sought after is obtained as a colourless oil (yield = 40 0/a).
'H NMR (250 MHz, DMSO) 8: 6.80 Cs, 2K); 4.13 (in, 1K) ; 4.05 Cm, 2K); 3.79 Cs, 3K) ; 3.65 (in, 1K) ; 3.50 Ct, 2K) ; 3.22 Ct, 2K) ; 2.91 (in, 4K)
2.70 Cs, 3K) ; 2.60 (in, 2K) ; 2.51 Cs, 6K) ; 1.85 (in, 8K); 1.45 (in, 2K) ;
0.96 Cm, 2K).
Example 142
4-methoxy- N,2,6-trimethyl- N-[2- [2- [4- [(8-methyl-B-
azabicyclo[3. 2. 1]oct-3-yI)amino]-1-piperidinyl]-2-oxoethoxy]-ethyl]benzenesulphonamide, bis(trifluoroacetate)
A mixture of 140 ing (0.26 mM) of the compound obtained according to Example 141 is agitated until dissolution in 4 ml of a solution of 60/a trifluoroacetic acid in water. The solution is frozen and freeze-dried and 200 ing of the product sought after are thus obtained as a white solid (quantitative yield).
M.Pt. = 70 0C

In operating analogously to preparation CLI and to Examples 140 to 142, starting with t-butyl methylC4-pi peridi nyl)carbamate, the following compounds are obtained:

PREPARATION CLII
[1-[[2-[[(4-methoxy-2,6-dimethylphenyl)sulphonyl]methyl-amino]ethoxy]acetyl]-4-piperidinyl]methylcarbam ic acid, 1,1-dimethylethyl ester
Colourless oil (yield = 49 0/a).
'H NMR (300 MHz, DMSO) 8: 6.80 (5, 2H); 4.38 (in, 1K); 4.32 (in, 1K); 4.07 Cm, 2K); 4.01 Cm, 1K); 3.80 (5, 3K); 3.74 (in, 1K); 3.54 (in, 2K);
3.23 Ct, 2K); 2.93 (in, 1K); 2.70 Cs, 3K); 2.63 Cs, 3K); 2.53 Cs, 6K);
1.53 (in, 4K); 1.39 (5, 9K).

Example 143
4-methoxy-N,2,6-trimethyl- N- [2-[2-[4-(methylam mo)- 1-
piperidinyl]-2-oxoethoxy]ethyl]- benzenesulphonamide
Colourless oil (yield = 99 0/a).
'H NMR (250 MHz, DMSO) 8: 6.80 Cs, 2H); 4.18 Cm, 1H); 4.08 Cm, 2H);
3.80 Cs, 3H); 3.68 (in, 1K); 3.54 Ct, 2K); 3.23 Ct, 2H) ; 2.95 Cm, 1H);
2.85 (in, 1H); 2.70 Cs, 3H); 2.67 (in, 1H); 2.53 Cs, 6K); 2.42 Cs, 3K);
1.85 (in, 2K); 1.25 (in, 2K).

Example 144
4-methoxy- N,2,6-trimethyl-N- (2- [2-[4-[methyl(8-methyl-8-azabicyclo[3.2. 1]oct-3-yI)amino]- 1-piperidinyl]-2-oxoethoxy]ethyl]benzenesulphonam,de
Colourless oil (yield = 34 %).
'K NMR (300 MHz, DMSO) 8: 6.80 Cs, 2K) ; 4.30 Cm, 1K) ; 4.10 (q, 2K);
3.80 Cs, 3H) ; 3.67 (in, 1K) ; 3.52 Ct, 2K) ; 3.30 (in, 2K) ; 3.21 Ct, 2K)
2.88 (in, 1K) ; 2.75 Cm, 2K) ; 2.70 Cs, 3K); 2.53 Cs, 6H) ; 2.49 (in, 1K)
2.14 Cs, 3K); 2.05 Cs, 3K); 1.89 Cm, 2K); 1.45 Cm, 8K); 1.23 (in, 2K).

ExamDte 145
4-methoxy- N, 2,6-trimethyl- N-[2- [2- [4- [methyl(8-methyt-8-azabicyclo[3. 2.1]oct-3-yI)amino]- 1-piperidinyl]-2-oxoethoxyjethyl] benzenesul phonam ide, bis(trifluoroacetate)
Colourless oil (yield = 99 %).
'K NMR (250 MHz, CD3CN) 8: 6.75 (5, 2K); 4.62 Cm, 1K); 4.06 (in, 2K); 3.97 (in, 2K); 3.92 Cm, 1K) ; 3.81 (5, 3K); 3.65 Cm, 1K) ; 3.59 (in, 3K); 3.30 Ct, 2K); 3.05 (in, 1K); 2.74 Cs, 3K); 2.71 (d, 3K); 2.63 Cs, 3K); 2.70-2.55 (in, 3K); 2.53 Cs, 6K); 2.27 Cm, 4K); 1.97 (in, 4K);
1.62 (in, 2K).

PREPARATION CLIII
4-[( 1-[( 1, 1-dimethylethoxy)ca rbonyl]-4-piperidinyl]methyl]-1-piperazinecarboxylic acid, phenylmethyl ester

In operating analogously to preparation LXXI, starting with the t-butyl ester of 4-formyl-1-piperidinecarboxylic acid and with the benzyl ester of 1-piperazinecarboxylic acid, the product sought after is obtained as a colourless oil (yield = 26 0/a).
'K NMR (300 MHz, DMSO) 6: 7.31 Cm, 5K); 5.11 Cs, 2K) ; 3.90 Cm, 2K) 3.64 Cm, 4K); 2.75 (in, 8K); 1.89 Cm, 1K) ; 1.70 Cm, 2K) ; 1.39 Cs, 9K)
1.04 (in, 2K).

PREPARATION CLIV
4-(4-piperidinylmethyl)- 1-piperazinecarboxylic acid, phenylmethyl ester
In operating analogously to preparation XXIX, starting with the compound obtained according to preparation CLIII, the product sought after is obtained as a colourless oil (yield = 83 0/a).
'H NMR (250 MHz, DMSO) 8: 7.35 Cm, 5K); 5.00 Cs, 2K); 3.35 Cm, 4K); 2.95 (in, 2K); 2.46 Cm, 2K); 2.30 (in, 4K); 2.11 (in, 2K); 1.65 (in, 3K);
0.98 (in, 2K).

PREPARATION CLV
4-[[ 1-[[2-E[(4-methoxy-2,6-dimethylphenyl)sul phonyl]methylamino]ethoxy]acetyl]-4- piperidinyl]methyl]- 1-piperazinecarboxylic acid, phenylmethyl ester
In operating analogously to Example 72, starting with the compound obtained according to preparation CLIV, the product sought after is obtained as a colourless oil (yield = 70 %).
'H NMR (250 MHz, DMSO) 8: 7.35 Cm, 5K) ; 6.80 Cs, 2K) ; 5.07 Cs, 2K) 4.25 (in, 1K); 4.05 Cm, 2K) ; 3.79 Cs, 3K); 3.68 (in, 1K) ; 3.53 Ct, 2K) ;
3.30 (in, 4K) ; 3.21 Ct, 2K) ; 2.88 (in, 1K) ; 2.69 Cs, 3K) ; 2.53 Cs, 6K) ;
2.51 (in, 1K); 2.31 Cm, 4K); 2.27 (in, 2K); 1.70 Cm, 3K) ; 0.95 (in, 2K).

Example 146
4-methoxy- N,2,6-trimethyl- N- [2-[2-oxo-2-[4-( 1-piperazinyl-
methyl)- 1-piperidinyl]ethoxy]ethyl]benzenesulphonamide
In operating analogously to preparation XXXV, starting with the compound obtained according to preparation CLV, the product sought after is obtained as a colourless oil (yield = 93 0/~4
'K NMR (300 MHz, DMSO) 8: 6.80 Cs, 2K) ; 4.25 (in, 1K) ; 4.05 (q, 2K)
3.79 Cs, 3K) ; 3.54 (in, 1K) ; 3.51 Ct, 2K) ; 3.23 Ct, 2K) ; 2.87 Cm, 1K)
2.70 Cs, 3K); 2.66 (in, 4K) ; 2.53 Cs, 6K); 2.50 Cm, 1K) ; 2.46 (in, 4K)
2.05 Cd, 2K); 1.74 Cm, 3K) ; 0.98 Cm, 2K).

Example 147
4-methoxy-N,2,6-trimethyl- N- [2-[2-oxo-2-[4-( 1-piperazinyl-methyl)- 1-piperidinyl]ethoxy]ethyl]benzenesulphonamide, fuma rate
In operating analogously to Example 73, starting with the compound obtained according to Example 146, the product sought after is obtained as a white solid (yield = 93 oA,).
M.Pt. = 85-87 GC

PREPARATION CLVI 1-[[2-[[(4-methoxy-2,6-dimethylphenyl)sulphonyl]methylamino]
ethoxy]acetyl]- 4-piperidinecarboxylic acid, ethyl ester
In operating analogously to Example 70, starting with the ethyl ester of 4-piperidinecarboxylic acid, the product sought after is obtained as a colourless oil (yield = 89 %).
'K NMR (250 MHz, DMSO) 8: 6.80 Cs, 2K); 4.17 Cm, 5K); 3.80 Cs, 3K); 3.65 (in, 1K); 3.53 Ct, 2K); 3.29 (5, 3K); 3.21 Ct, 2K); 2.99 Cm, 1K);
2.72 (in, 1K); 2.70 Cs, 3K); 2.58 Cm, 1K); 2.53 (5, 6K); 1.83 Cm, 2K);
1.44 (in, 2K); 1.20 Ct, 3K).
PREPARATION CLVII
1-[[2-[[(4-methoxy-2,6-dimethylphenyl)sulphonyl ]methylamino]
ethoxyjacetyl]- 4-piperidinecarboxylic acid
A solution is prepared of 2.3 g (4.89 mM) of ester obtained according to preparation CLVI in 40 ml of tetrahydrofuran and a solution of 246 ing (5.8 mM) of lithia in 3 ml of water is added. The mixture is agitated at ambient temperature overnight and then concentrated under reduced pressure. The residue is taken up into 25 ml of water, acidified up to pH 2 with an N solution of hydrochloric acid and extracted with ethyl acetate. The organic phase is dried over magnesium sulphate and concentrated under reduced pressure. The crude product is purified by silica gel chromatography in eluting with the aid of a dichloromethane/methanol mixture (95/5; v/v). 1.6 g of the compound sought after are obtained as a colourless oil (yield = 74 %).
'K NMR (300 MHz, DMSO) 8: 6.80 Cs, 2K); 4.10 Cm, 1K); 4.06 Cm, 2K); 3.79 (5, 3K); 3.55 Cm, 1K); 3.53 Ct, 2K); 3.23 Ct, 2K); 2.98 (in, 1K);
2.74 (in, 1K); 2.70 Cs, 3K); 2.53 Cs, 3K); 2.50 Cs, 6K); 2.43 (in, 1K);
1.85 (in, 2K); 1.40 (in, 2K).

Example 148
4-methoxy-N,2,6-trimethyl- N-[2- [2-oxo-2-[4-[1-oxo-2-(4-methyl-1-piperazinyl)ethyl]-1-piperidinyljethoxy]-
ethyl] benzenesul phonam ide, bis(trifiuoroacetate)
A solution is prepared of 0.65g (1.47 mM) of acid obtained according to preparation CLVII in 20 ml of dichloromethane and 0.25 ml of oxalyl chloride are added. The mixture is agitated for 2 hours at ambient temperature and is concentrated under reduced pressure. The yellow oil obtained is taken up into 8 ml of tetrahydrofuran and 8 ml of acetonitrile and, at 0 0C, 0.74 ml (1.47 mM) of a 2M solution of
trimethylsilyldiazomethane in hexane are added. The mixture is agitated 1
hour at ambient temperature and then concentrated under reduced pressure. The residue is taken up into solution in 10 ml of chloroform and is added dropwise to a solution of 147 ing (1.47 mM) of Nmethylpiperazine in 10 ml of chloroform, in the presence of 10 ing of chlorocyclopentadienylbis(triphenylphosphine)ruthenium(II), at 600C. The reaction mixture is agitated at 600C for 30 mm and then concentrated under reduced pressure. The crude product is purified by silica gel chromatography in eluting with the aid of a dichloromethane/methanol mixture (85/15; v/v). The oily product obtained is salified directly trifluoroacetic acid in applying the procedure described in Example 142. 0.167 g of the compound sought after are obtained as a colourless oil (yield = 21 0/a).
'K NMR (300 MHz, CD3CN) 8: 6.75 Cs, 2K) ; 4.35 Cm, 1K) ; 4.04 (in, 2K) 3.83 Cs, 3K); 3.81 Cs, 2K); 3.70 (in, 1K) ; 3.58 Ct, 2K); 3.38 Cm, 4K);
3.30 Ct, 2K) ; 3.22 (in, 4K) ; 2.95 Cm, 1K) ; 2.81 (5, 3K) ; 2.74 Cs, 3K)
2.69 Cm, 2K); 2.56 Cs, 6K); 1.80 (in, 2K); 1.45 (in, 2K).

Example 149
4-methoxy- iV,2,6-trimethyl- N-[2- [2-[4-( 1-methyl-4-piperidinyl)]-
1-piperazinyl]-2-oxoethoxy]ethyl]benzenesulphonamide
A solution is prepared of 7 g (21 mM) of acid obtained according to preparation III in 50 ml of chloroform and 0.1 ml of dimethylformamide and, at ambient temperature, a solution of 3.7 ml (42 mM) of oxalyl chloride in 8 ml of chloroform, is added dropwise. The reaction mixture is agitated for 3 hours at ambient temperature and concentrated under reduced pressure. The residue from evaporation is taken up into 20 ml of chloroform and is added slowly, at 00C, to a solution of 4.04 g (22 mM) of 1-(1-methyl-4-piperidinyl)piperazine and 8.7 ml of triethylamine in 40 ml of chloroform. The reaction mixture is agitated for 1 hour at 00C and then
poured over 60 ml of iced water. The mixture obtained is extracted with 100 ml of chloroform and the organic phase is washed with a solution of sodium bicarbonate, and then with water, dried over magnesium sulphate and concentrated under reduced pressure. The product sought after is thus obtained as an oil (yield = 81.70/a) which is used, without other purification, to obtain a salt with an acid.

Example 150
4-methoxy- N,2,6-trimethyl- N-[2-[2-[4-( 1-methyl-4-piperidinyl)]-
1-piperazinyl]-2-oxoethoxy]ethyl]benzenesulphonamide, dihydrochioride
A solution is prepared of 6 g (12 mM) of the compound obtained according to Example 149 in 100 ml of ethanol heated to around 650C. 3.2 ml (36 mM) of concentrated hydrochloric acid are then added, at around 600C. A precipitate forms rapidly. After 2 hours under agitation at ambient temperature, the suspension is cooled to 00C and filtered on a sinter. The solid isolated is washed with 10 ml of cold ethanol and then with 15 ml of ethyl ether and dried under reduced pressure. 5.2 g of the salt sought after are thus obtained as a white solid (yield = 75 %).
M.Pt. 2500C

Example 151
4-methoxy- N,2,6-trimethyl-N-[2- [2-[4-( 1-methyl-4-piperidinyl)]-
1-piperazinylJ-2-oxoethoxy]ethyl]benzenesulphonamide, difumarate
In operating analogously to Example 150, with 2.5 equivalents of fumaric acid, the product sought after is obtained as a white solid (yield = 76 0/a).
M.Pt. = 185 0C
Table
(Table Removed)

In the above table, trifluoroacetic acid,
Is means a single bond, TFA means that the compound is in the form of a salt with F means that the compound is in the form of a salt with fumaric acid.
HCI means that the compound is in the form of a salt with hydrochloric acid.
Biological activity
The compounds of the present invention were evaluated for their analgesic property using the formalin-induced pain response test in mice (Shibata, M., Ohkubo, T., Takahashi, K. & P.. Inoki. Modified formalin test:
characteristic biphasic pain response. Pain, 38, 347-352). To summarize, formalin (0.92 0/a in physiological saline) is injected into the hind paw and the period of paw licking, which represents pain intensity, is recorded from 0 to 5 mm (1~ phase) and from 15 to 30 mm (2nd phase) after the injection. According to this test, the percentage inhibition of the second paw licking phase induced by formalin is 43% for the compound of example 4 administered via the oral route at a dose of 3 mg/kg and 40 0/~ for the compound of example 6 administered via the oral route at a dose of 1 mg/kg.
These results demonstrate a substantial lowering of pain response after administering the compounds.
Subsequent to the results of the preceding test, the compounds of the invention were subjected to a test intended to demonstrate their mode of action and involving the B, receptor of bradykinin.
This test uses the human umbilical vein and is conducted as per the following protocol:
Human umbilical cords 15-25 cm long are recovered just after delivery and are immediately placed in a flask containing a Krebs solution of composition (in mM): 119 NaCI 119, 4.7 KCI, 1.18 KK2PO4, 1.17 MgSO4, 25 NaKCO3, 2.5 CaCI2, 5.5 Glucose, 0.026 EDTA then stored at 40C.
The cord is dissected in Krebs solution to release the umbilical vein. The vein is cleansed of all adhering tissue and cut into small rings 3-4 mm in width. The endothelium is carefully removed by inserting a fine n0 1 catheter, made slightly abrasive, into the vessel lumen.
To induce expression of the B, receptor of bradykinin, the vein segments are allowed to incubate at 37GC in a 25 ml chamber for 16

hours in an EMEM culture medium oxygenated by a 950/a 02 + 50/a CO2 mixture to which antibiotics are added: penicillin 10 000 lU/mi and streptomycin 10 000 lU/mI. The following day, the vein rings are mounted on a stainless steel support connected to an isometric sensor and placed in a 8 ml isolated organ bath chamber thermostated at 370C, containing the Krebs solution oxygenated by a 95% 02 + 5% CO2 mixture.
After a rest period of one hour during which the rings are rinsed 5 to 6 times with the Krebs solution (maintained at 37GC throughout the entire handling procedure and oxygenated by a 950/a 02 + Sa/a CO2 mixture), the vein is gradually subjected to a ig load. When the load is stable, after approximately 45 minutes, the Krebs solution is replaced by a hyper-potassium solution (KPSS: at a temperature of 37GC) of the same composition but containing 125 mM KCI and not NaCI.
After a series of rinsings, rests and load readjustments, the maximum contraction of each segment is determined by further depolarisation with the KPSS solution.
After a new rest period during which the ig load is constantly readjusted, the following compounds are added to the isolated organ bath: Mepyramine (1 pM), Atropine (1 pM), Indometacine (3 pM), LNA (30 pM), Captopril (10 pM), DL-Thiorphan (1 pM) and Nifedipine (0.1 pM).
After 20 minutes, the molecule to be tested or the molecule solvent is added to the isolated organ bath. The molecules are examined at 10 pM; should a molecule show a sufficient level of activity, it is examined at lower concentrations (eg: 1 — 0.1-0.01 pM).
After 15 minutes incubation, the vein segments are contracted through the addition of increasing concentrations of des-ArglO-Kallidin (0.1 nM to 30 000 nM) in the chamber.
The EC50 values (effective concentrations of agonists required to produce 5O0/a of the maximum response obtained with KPSS) are calculated using the least square method.

(Table Removed)
The pK8 = [-logK8] is obtained from the equation:
KB = [A] / (concentration ratio-i)
n which [A] is the concentration of antagonist and the (concentration ratio) represents the ratio between ECsa in the presence of an antagonist and EC50 in the absence of antagonist.
According to this test, the compounds of the invention cited in the description show a PKB value of more than 7.
By way of example, the pK8 values of some compounds of the invention are given in table II:
The compounds of the present invention may be used to treat various forms of pain such as inflammatory hyperalgesia, allodynia, neuropathic pain assoicated with, for example, diabetes, with neuropathies (constriction of sciatica nerve, lumbago), with any form of trauma, surgery (tooth extraction, tonsil removal), interstitial cystitis, inflammatory colon disease, or with cancer.
The compounds of the present invention may also be used to treat any pathology associated with neutrophil migration such as acute respiratory distress syndrome for example, or psoriasis, chronic lung obstructions, inflammatory diseases, in particular inflammatory diseases of the colon, rheumatoid polyarthritis.
The activity of the compounds of the. invention, evidenced during the biological tests, is indicative of analgesic properties and permits their considered use for therapy.
According to the invention, the use is advocated of compounds defined by formula I and of their salts with non-toxic acids, preferably their pharmaceutically acceptable salts, as active ingredients in medicinal products intended for the treatment of mammals, notably in man, suffering from pain or certain diseases generally characterized by massive neutrophil migration.
Among the diseases which can be treated by administering a therapeutically efficient quantity of at least one of the formula I compounds, mention may be made of inflammatory hyperalgesia, neuropathic pain, pain assoicated with trauma or with cancer, inflammatory diseases of the colon, rheumatoid polyarthritis, psoriasis, chronic lung obstructions or acute respiratory distress syndrome.
The invention also concerns a method for treating pain or the above-mentioned diseases which consists of administering a therapeutically efficient quantity of a formula I compound to patients in need thereof.
The dose of active ingredient is dependent upon the mode of administration and type of pathology; it is generally between 0.05 and 10 mg/kg of the treated patient. In relation to the intended treatment, the formula I compounds or their salts may be associated with other active ingredients and are to be formulated with routinely used excipients.
To obtain swift action, notably for the treatment of acute pain, the method of administration of the medicinal product is preferably by injection, for example via the intramuscular or the subcutaneous route. For chronic pain, the medicinal product may be administered in common galenic formulations, for example via the oral route in capsule or tablet form, in which a compound of the invention is associated with excipients known to persons skilled in the art, or in adhesive patch form in which a compound of the invention is formulated with excipients known to persons skilled in the art to promote transdermal passing of the active ingredient.

The composition of present invention comprising at least one physiologically acceptable excipient, it contains at least one benzene surfonamide compound of Formula I or one of its pharmaceutically acceptable addition salts with an acid shows synergistic properties exhibiting surprising results.

WE CLAIM:
1. A novel benzenesulphonamide compound, of formula I:

(Formula Removed)
in which
- R1, R2, R3, R4 each independently represent one or more atoms or groups of atoms selected from a hydrogen atom, the halogens, C1-C3 alkyl groups, or C1-C3 alkoxy groups, CF3 or OCF3 groups,
- Ra represents a C1-C4 alkyl group,
- Y represents a saturated C2-C5 alkylene group, optionally interrupted by an oxygen atom, an unsaturated C2-C4 alkylene group, or a -CH2-CO-NH-CH2-group,
- X represents CH or a nitrogen atom,
- p represents 2 or 3,
- A represents a single bond, a nitrogen atom optionally substituted with a methyl group, or a straight or branched C1-C5 alkylene group optionally hydroxylated or of which one of the carbon atoms is oxidized into a ketone function, provided that A and X together do not represent a nitrogen atom,
- B represents a nitrogen-containing heterocycle or an amine group optionally substituted with one or two C1-C4 alkyl groups;
or an addition salt of said compound with an acid.
2. A novel benzenesulphonamide compound as claimed in claim 1, wherein Y represents a C3-C5 alkylene group interrupted by an oxygen atom, preferably a-CH2-CH2-O-CH2- group.

3. A novel benzenesulphonamide compound as claimed in claim 1, wherein R2
and R3 represent a methyl group at position 2,6 on the aromatic ring.
4. A method for preparing a novel benzenesulphonamide compound of
formula I as claimed in claim 1, and its addition salts, comprising the steps consisting
of:
a) allowing an acid of formula:
(Formula Removed)
in which
R1, R2, R3 and R4 each independently represent a hydrogen or halogen atom, a C1-C3
alkyl group, or a C1-C3 alkoxy group, CF3 or OCF3 group,
Ra represents a C1-C4 alkyl group,
Y represents a saturated C2-C5 alkylene group, optionally interrupted by an oxygen
atom, an unsaturated C2-C4 alkylene group, or a -CH2-CO-NH-CH2- group,
to react with a nitrogen-containing heterocycle of formula:
(Formula Removed)
in which
X represents CH or a nitrogen atom,
p represents 2 or 3,
A represents a single bond, a nitrogen atom optionally substituted with a methyl
group (if X does not represent a nitrogen atom), or a straight or branched C1-C5
alkyl one group, optionally hydroxylated or of which one of the carbon atoms is oxidized into a ketone function,
B represents a nitrogen-containing heterocycle or an amine group optionally substituted with one or two C1-C4 alkyl groups, on the understanding that, should a non-substituted nitrogen atom be present, this nitrogen atom is protected by an amino-protecting group,
in a solvent selected from the group consisting of tetrahydrofuran, dichloromethane and dimethylformamide, in the presence of activators selected from the group consisting of EDCI (l-(3-dimethylaminopropyl)-3-ethylcarbodiimide), DIC (diisopropylcarbodiimide) and HOAT (l-hydroxy-7-azabenzotriazole), at a temperature lying between ambient temperature and the boiling point of the solvent, for approximately 2 to 15 hours, to obtain the amide of formula:
(Formula Removed)
in which R1, R2, R3, R4, Ra, Y, p, X, A and B maintain the same meaning as in the starting products,
b) if necessary, removing the amino-protecting groups,
c) if necessary, obtaining an addition salt of the formula I compound with a mineral or organic acid.

5. A novel benzenesulphonamide compound as claimed in claim 1 useful for the preparation of a pharmaceutical composition.

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Patent Number

233149

Indian Patent Application Number

3814/DELNP/2005

PG Journal Number

13/2009

Publication Date

27-Mar-2009

Grant Date

27-Mar-2009

Date of Filing

26-Aug-2005

Name of Patentee

LABORATOIRES FOURNIER S.A.

Applicant Address

42 RUE DE LONGVIC, 21300 CHENOVE, FRANCE.

Inventors:

#	Inventor's Name	Inventor's Address
1	BONDOUX MICHEL	7 RUE DES MONTEREYS, 21121 FONTAINE-LES-DIJON- FRANCE.
2	DODEY PIERRE	10 RUE DES CHAMPS D'ALOUX, 21121 FONTAINE-LES-DIJON- FRANCE.
3	LUCCARINI JEAN-MICHEL	9 RUE CRONSTADT, 21000 DIJON-FRANCE.
4	BARTH MARTINE	20 RUE CLAUDE DESCHAULT, 21380 ASNIERES-LES-DIJON, FRANCE.
5	MASARDIER CHRISTINE	5 RUE NICOLAS FROCHOT, 21000 DIJON- FRANCE.
6	THOMAS DIDIER	22 IMPASSE DU VERT VILLAGE, 21850 SAINT-APOLLINAIRE- FRANCE.

PCT International Classification Number

C07D 417/04

PCT International Application Number

PCT/FR2004/000723

PCT International Filing date

2004-03-24

PCT Conventions:

#	PCT Application Number	Date of Convention	Priority Country
1	03 03602	2003-03-25	France
2	03 04530	2003-04-11	France