Title of Invention	"PROCESS FOR SYNTHESIS OF QUETIAPINE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF"
Abstract	Provided are a novel synthesis of quetiapine, quetiapine made by such process and its acid addition salts, and pharmaceutical composition comprising quetiapine so mad, or its acid addition salts.

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SYNTHESIS OF QUETIAPINE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF RELATED APPLICATIONS The present application claims the benefît of the February 22, 2003 filing date of United States Provisional Patent Application 60/448,934. FPELD OF THE INVENTION The prcsent invention relates to synthesis of quetiapine and pharmaceuticaHy acceptable salts thereof. BACKGROUND OF THE INVENTION The structure of quetiapine, 2-(2-(4-dibenzo[&t/][l,4Jthiazepm-ll-yl-l-piperazinyl)ethoxy)ethano], is shown below (I). (Figure Removed) Quetiapine is a psychoactive organic compound that is an antagonist for multiple neurotransmitter receptors in the brain. Merck Index, 13th Ed., 8130 (2001). Quetiapine is an anu'psychotic agent useful for treating, among other things, schizophreriia. Quetiapine can be made, for example, as taught in United States Patent 4,879,288, iiicorporated in its entirety herein by reference. As taught ui the '288 patent, quetiapine can be made m reaction of 11-piperazinyl dibenzo[Z),/]-[l,4]tliiazepiiiehydrochloride and 2-(2-chloroethoxy)ethanol in a solvent. Reaction times are long (e.g. 24 hours). Also, starting materials such as the 11-piperazinyl dibenzofA/j-fl^Jthiazepine are undesired in the product and can be difficult to remove from the product. There is a need for an improved process for making quetiapine from 11-piperazinyl diben2o[Z>jQ-[l,4]thiazepine allowing shorter reaction tirnes and affording a quetiapine product that contains a lower level of impurities (such as the unreacted starting material). SUMMARY OF THE INVENTION In one aspect, the present method relates to a process for making quetiapine comprising the step of reacting 11-piperazinyl dibeiizo[&t/]-[l,4]thiazepine hydrochloride and 2-(2-chloroethoxy)ethanol in a solvent, especially n-butanol, toluene, or dimethyl formamide, in the presence of a base, especially an inorganic base, most especially sodium carbonate, a phase transfer catalyst, especially tetrabutylammonium bromide, and, optionally, an alkali metal halide, especially sodium iodide. In another aspect, the present invention relates to quetiapine made by the foregoing process. In yet another aspect, the present invention relates to a process for making quetiapine heminimarate including the steps of: reacting 11-piperazinyl dibenzo[6,/]-[l,4]thiazepine hydrochloride and 2-(2-chIoroethoxy)ethanol in a solvent, especially «-butanol, toluene, or dimethyl formamide, in the preseuce of a base, especially an inorganic base, most especially sodium carbonate, a phase transfer catalyst, especially tetrabutyammonium biomide, and, optionally, an alkali metal halide, especially sodium iodide, whereby a fîrst slurry is obtained; separating the solid from the fîrst slurry, whereby a liquid filtrate is obtained; combining the liquid filtrate with fumărie acid, whereby a second slurry is obtained; and isolating quetiapine hemifumarate from the second slurry. In this aspect, the present invention also relates to recrystallizion of the quetiapine heminimarate so obtained from a solvent, that is a lower alkanol, especially ethanol, or amixture of water and a dipolar aprotic solvent, especially dimethyl formamide. In still a further aspect, the present invention relates to a pharmaceutical composition, and dosage forms thereof, including at least one pharmaceutically acceptable excipient and quetiapine hemijfumarate made by the foregoing described process in any of its embodiments. DETAILED DESCRIPTION OF THE INVENTION The present invention provides a process of making quetiapine - 11-[4-[2-(2-hydroxyethoxy)ethyl]-l-piperazin.yl]dibenzo[6,_/]-[l,4]tbiazepine - in shorter time and with lower amounts of dif5cult-to-remove residual 11-piperazinyl dibenzo[6,/|-[l,4]thiazepine than hîtherto reaHzable with the methods of the prior art. The process of the present invention is readily adapted to encompass the preparation of pharmaceutically acceptable salts of quetiapine, especially quetiapine hemifumarate. As used herein, slurry refers to undissolved particles in a liquid. The process of the present invention includes the step of reacting, in a suitable vessel, preferably with agitation (e.g. stirring), 11-piperazinyl dibenzo[&/)]-[l,4]thiazepiue with 2-(2-chloroethoxy)ethanol in a solvent in the presence of a base, a phase transfer catalyst, and, optionally, an alkali metal halide. The reacting is preferably at a temperature greater than about 100°C, especially at reflux. The skilled artisan understands that reference to 11-piperazinyl dibenzo[&3-[l,4]thiazepine hydrochloride refers to the well-know dihydrochloride referred as such to in the prior art. Phase transfer catalysts are an important aspect of the present invention and are well known to one skilled in the art of organic synthesis. Phase transfer catalysts are of particular utility when at least fîrst and second compounds to be reacted with each other have such dififerent solubility characteristics that there is no practicai common solvent for them and, accordingly, combining a solvent for one of them with a solvent for the other of them results in a two-phase system. The phase transfer catalysts useful in the practice of the present invention are of the same type and used in the same manner and amounts as the phase transfer catalysts well known in the art. Examples of phase transfer catalysts useful in the practice opf the present invention include tetrabutylammonium bromide, triethylbenzylammoniurn chloride, and tricetylmethylammonium chloride (Aliquot® 336). Tetrabutylammonium bromide is a preferred phase transfer catalyst in the practice of the method of the present invention. The solvents useful in the practice of the present invention include the lower alkanols, aromatic hydrocarbons, and the so-called dipolar aprotic solvents. Preferably, the solvent has a boiling point at normal atmospheric pressure of about 100° C or higher. Lower alkanols are linear or branched aliphatic alcohols of general formula CnH2n+iOH, where n is l to about 6. Normal butanol (n = 4) is aparticularlypreferred lower alkanol for use in the practice of the present invention in certain of its embodiments. Aromatic hydrocarbons useful as solvents in this and other embodiments of the present invention are normally liquids at room temperature (about 20° to about 27°C) and have the general formula CnHn> but can be substituted with one or more linear or branched C i - Q alkyl groups; or other groups that do not interfere with the reaction. Toluene (n = 6, methyl substituent) and xylene are particularly preferred aromatic hydrocarbons for use in the practice of the present invention. The so-called dipolar aprotic solvent are well known as such in the art. Such solvents have a permanent dipole, but no readily removeable hydrogen atoms. Examples of well-known dipolar aprotic solvents include dimethyl formamide (DMF), dimethyl acetamide (DMAC), dimethy sulfoxide (DMSO), N-methyl pyrrolidone (NMP) and the like. Dimethyl formamide is a preferred dipolar aprotic solvent for use in the practice of the present invention in its several embodiments. The solvent used can also be a mixture of one or more of the same or different classes (types) of solvent described above. The base used in the practice of the present invention can be an inorganic base. Inorganic bases are inorganic compounds that are capable of reacting with and neutralizing an acid, especially a Brenstead acid. Examples of inorganic bases include alkali metal and alkalme earth metal oxides, hydroxides, bicarbonates, and carbonates. Alkali metal carbonates, especially sodium carbonate, are preferred inorganic bases for use in the practice of the present invention. When an opţional alkali metal halide is used, sodium iodide is the preferred alkali metal halide. 11-Piperazinyl dibenzo[b,fj-[l,4]tliia2:epmehydrochloride , 2-(2-chloroethoxy)ethanol, solvent, base, alkali metal halide, and phase transfer catalyst are combined, in any order, in a suitable reaction vessel that is preferably equipped with an agitator. The relative molar amounts of the materials combined are not criticai. Typicaily, the mo Iar amount of chloroethoxy ethanol will be l to 2 times the molar amount of the thiazepine hydrochloride; the molar amount of base will be 4 to 8 times the molar amount of the thiazepine hydrochloride; and the amount of alkali metal iodide will be a fraction of the molar amount of thiazepine hydrochloride. The phase transfer catalyst is used in an amount of about 0.1% to about 0.7% on a weight basis. Typically, the reaction mixture will initially be about 0.5M to 1.5M in the thiazepine hydrochloride, but higher or lower concentrations can be used whilst realizing the benefits of the present invention. The contents of the reaction vessel are preferably protected from excessive atmospheric water by providing a pad of dry inert gas over the reaction mixture, or by isolating the interior of the reaction vessel from the environment through a desiccant (e.g. molecular sieves, CaCla, or the like). The contents of the reaction vessel are heated to a reaction temperature of from about 80°C to about 100°C or higher, preferably to the reflux temperature. The reaction mixture is held at .the reaction temperature for a reaction time of about 12 to about 24 hours. Typically, a reaction time of about 17 hours is sufficient. At the end of the reaction time, the reaction is a soh'd/liquid slurry. The two-phase (s/l) reaction mixture is cooled and the solid phase separated by a suitable means whereby a liquid filtrate containing the product (quetiapine base) is obtamed. The separation can be by any means known in the art, for example filtration (gravity or suction) or centrifugation - decanting, to mention just two. The product quetiapine base can be isolated from the filtrate by any means known in the art, for example distillation / evaporation of the solvent, preferably at reduced pressure ( Pharmacutically acceptable acid addition salts are salts obtainable from quetiapine base by qutemarization of at least one amine functionality in the product; can be readily processed to the desired dosage form; and are nontoxic at the dosages used. The isolated quetiapine can be converted to apharmaceutically acceptable acid addition salt by dissolving it in a salinization solvent and combining the solution so obtained with the desired acid, for example fumărie acid. Typically, the acid addition salt will precipitate from the solvent upon cooling (if not before) and can be isolated by any means known in the art, for example fîltration (gravity or suction) or centrifugation - decanting, to mention just two. Salinization solvents useful in the practice of the present invention include water, alcohols (e.g. methanol, butanol), esters (e.g. ethyl or butyl acetate), ketones (e.g. acetone), DMF, DMSO, or mixtures of solvents like DMSO/chlorofonn, DMF/water, or NMP/acetonitrile. hi another and preferred embodiment, the quetiapine product is converted to a pharmaceutically acceptable acid addition salt, preferably the hemifumarate, without being isolated from the fîrst filtrate, hi this erabodiment, fîrst liquid filtrate is obtained as above and combined with the desired axnount of acid, e.g. fumărie acid. The resulting combination is optionally heated to about 100° C and thereafter cooled, whereby a second slurry, containing solid acid addition salt, is obtained. The pharmaceutically acceptable acid addition salt is isolated from the second slurry by any means known in the art, for example filtration (gravity or suction) or centrifugation - decanting, to mention just two. Jf desired, the pharmaceutically acceptable acid addition salt can be recrystallized using, for example, any of the salinization solvents mentioned above. hi particular, the crude quetiapine hemifumarate can be advantageously recrystallized from a solvent that is a lower alkanol, preferabiy ethanol, or a mixture of water and a dipolar aprotic solvent, preferably dimethyl formamide. Quetiapine or, preferably, an acid addition salt thereof, most preferably quetapine hemiftimarate, obtained by the process of the present invention can be formulated into pharmaceutical compositions, preferably in a dosage form suitable for oral or parenteral adrninistration by methods known hi the art. The pharmaceutical compositions of the present invention can be m the form of a dosage form and prepared using diluents or phannaceuticaU acceptable excipients such as carriers, fillers, bulking agents, binders, wetting agents, disintegrating agents, surface active ageuts, lubricants, and the like. For the pharmaceutical compositions, various types of adrninistration unit forms can be selected depending on the therapeutic purpose, for example tablets, pills, powders, h'quids, suspensions, emulsions, granules, capsules, suppositories, injectkm preparations (solutions and suspensions), and the like. Any excipient commonly known and used widely in the art and that is pharmaceutically acceptable (e.g. nontoxic at the levels consumed with tlie quetiapine hemiftimarate) can be used in the pharmaceutical composition. Carriers include, but are not limited to, lactose, white sugar, sodium chloride, glucose, urea, starch, calcium carbonate, kaolin, crystalline cellulose, and silicic acid. Binders include, but are not limited to, water, ethanol, propanol, simple syrup, glucose solutions, starch Solutions, gelatin solutions, carboxymethyl cellulose, shelac, methyl cellulose, potassium phosphate, and polyvinylpyrrolidone. Disintegrating agents include, but are not limited to, dried starch, sodium alginate, agar powder, laminalia powder, sodium hydrogen cai-bonate, calcium carbonate, fatty acid esters of polyoxyethylene sorbitan, sodium laurylsulfate, monoglyceride of stearic acid, starch, and lactose. Disintegration inhibitors include, but are not limited to, white sugar, stearin, coconut butter, and hydrogenated oils. Absorption accelerators include, but are not limited to, quaternary ammonium base and sodium laurylsulfate. Wetting agents include, but are not limited to, glycerin and starch. Adsorbing agents include, but are not limited to, starch, lactose, kaolin, bentonite, and colloidal silicic acid. Lubricants include, but are not limited to, purified talc, stearates, boric acid powder, and polyethylene glycol. Tablets can be further coated with commonly known coating materials such as sugar coated tablete, gelatin film coated tablets, tablets coated with enteric coatings, tablets coated with fîkns, double layered tablets, and multi-layered tablets. When shaping the pharmaceutical composition into an oral solid dosage form, any commonly known excipient used ui the art can be used. For example, carriers include, but are not limited to, lactose, starch, coconut butter, hardened vegetable oils, kaolin, and talc. Binders include, but are not limited to, gum arabic powder, tragacanth gum powder, gelatin, and ethanol. Disintegrating agents include, but are not limited to, agar, and laminalia. For the purpose of shaping the phannaceutical composition in the form of suppositories, any commonly known excipient used in the art can be used. For example, excipients include, but are not limited to, polyethylene glycols, coconut butter, higher alcohols, esters of higher alcohols, gelatin, and semisynthesized glycerides. When preparing injectable (parenteral) pharmaceutical compositions, solutions and suspensions are sterilized and are preferably made isotonic to blood. Injection preparations may use carriers commonly kno\vn in the art. For example, carriers for injectable preparations include, but are not limited to, water, ethyl alcohol, propylene glycol, ethoxylated isostearyl alcohol, polyoxylated isostearyl alcohol, and fatty acid esters of polyoxyethylene sorbitan. One of ordinary ski U in the art can easily determine with little or no experimentation the amount of sodium chloride, glucose, or glycerin necessary to make the injectable preparation isotonic. Additional ingredients, such as dissolving agents, buffer agents, and analgesic agents raay be added. If necessary, coloring agents, preservatives, perfumes, seasoning agents, sweetening agents, and other medicines may also be added to the desired preparations. The amotint of queriapine hemifumarate contained in a pharmaceurical composition is not specifically restricted, however, the dose should be sufficient to treat, ameliorate, or reduce the symptoms associated with the psycological disease or disturbance being treated. Methods of administration of a pharmaceutical composition of the present invention are not specifically restricted, and can be administered in various preparations depending on the age, sex, and symptoms of the patient. For example, tablets, pills, solutions, suspensions, eraulsions, granules and capsules may be orally administered. Injection preparations may be administered individually or mixed with injection transfusions such as glucose solutions and amino acid solutions intravenously. If necessary, the injection preparations are administered singly intramuscularly, intracutaneously, subcutaneously or intraperitoneally. Suppositories may be administered into the rectura. The dosage of a pharmaceutical composition according to the present invention will depend on the method of.use, the age, sex, and condition of the patient The present invention is certain of its embodiments is illustrated by the following nonlimiting working and comparative examples. Example l Reagents: 11-piperazinyl dibenzo[£][l,4] thiazepine hydrochloride 2,75 gr (7.5 mmole) 2-(2-chloroethoxy)ethanol 1.2 gr (9.6 mmole) Na2CO3 4.75 gr (45 mmole) Nai 40-50 mg (ca. 0.3 mmole) 77-Butanol 15 m L TBAB 0.5 gr Prpcedure: The reagents were charged to a round-bottomed flask and heated to 115° C -120°C under gentle reflux conditions for 24 hours. The heating was discontinued and the solution was cooled. The resulting slurry was filtered. The precipitate was washed twice with small portions of butanol. The washing were combined with the filtrate and the precipitate discarded. Fumărie acid (0.435 g, 3.75 mmole) was added to the filtrate, the mixture was heated on a boiling water bath. The flask was removed from the bath and quetiapine hemifumarate crystallized out. The precipitae was colleeted (isolated) by filtration and recrystallized from 28 mL ethanol, yielding 2.0 grams (60.4%). Example 2 Reagents: 11-piperazinyl dibenzo[3,/][l,4j thiazepine hydrochloride 5.5 gr (l 5 mmole) 2-(2-CbJoroethoxy) ethanol 2.4 gr (19 mmole) Na2C03 9.5 gr (90 mmole) Nai 90 mg (0.6 mmole) n-Butanol 30 mL TBABlgr i Procedure: The reagents were charged to a round-bottomed flask equipped with a magnetic stirrer and a condenser with a calcium chloride drying tube. The flask was set in an oii bath at 115°C -120°C and the contents of the flask stirred under gentle reflux. After 24 hours the heating was discontinued. The mixture was cooled and filtered. The precipitate colleeted on the Buchner filter was washed 2 times with butanol. The washings were combined with the filtrate and the precipitate was discarded. The filtrate was charged to a reaction vessel and fumărie acid (870 mg, 7.5 mmole) was charged to the vessel. The mixture was heated on an oii bath to boiling. The vessel was removed firom the oii bath and the contents allowed to cool, whereapon quetiapine hemifumarate crystallized out. The product hemifumarate was filtered and recrystallized from 60 mL //-butanoh Yield 4.7 grams (70.8%). Eşample.3 Reagents: 11-piperazinyl dibenzo [&][l,4] thiazepine hydrochloride 16.5 gr (44 mmole) 2-(2-Chloroethoxy) ethanol 7.2 gr (58 mmole) Ma2CO3 2S.5 gr (270 mmale) Nai 270 mg (0.18 mmole) TBABSgr Toluene 82.5 mL Procedare: The reagents were charged to a round-bottomed flask equipped with a magnetic stirrer and a condenser wilh a calcium chloride drying tube. The flask and contents were heated in an oii bath at 105°C under gentie reflux. After 24 hours, a Dean Stark trap was attached to the flask and the azeotropic mixture of water and toluene was distilled oul. The product remaining in the flask was filtered-off. The precipitate (salts) was washed on the Buchner filter with smail portions of toluene. The washings were combined with the filtrate and the precipitate was discarded. To the filtrate contained in a flask was added 2.6 gr (22 mmole) fumărie acid. The mixture was heated to boiling on a heating bath and then was removed firom the heating bath and stirring of the contents of theflask was continued. The quetiapine hemifumarate crystallized out. The flask was cooled in an ice bath and the contents filtered. The collected solid was recrystallized from 150 mL ethanol. Yield 14,0 grams 72%. Example4 Reagents: 11-piperazinyl dibenzo[&,/J[l,4] thiazepine hydrochloride 33 gr (86.9 mmole) 2-(2-Chloroethoxy) ethanol 14.4 gr (l 15.6 mmole) Na2C0357gr Nai 540 mg TBAB6gr Toluene 165 gr Procedure: The reagents were charged to a round-bottomed flask equipped with a magnetic stirrer and a condenser with a calcium chloride drying tube. The flask was heated on an oii bath at 107°C under gentle reflux. After 40 hours, the flask and contents were cooled slightly and contents of the flask filtered. The collected precipitate was washed with small portions of toluene. The wasMngs were combined with the filtrate and the precipitate was discarded The filtrate was divided into 4 equal portions which were worked up in four different ways: A: The filtrate was extracted with water. To the organic phase was added 1.43 gr (l 1.5 mmole) fumărie acid. The mixture was heated in a boiling water bath, removed from the bath and continued to ştir. Quetiapine hemirumarate crystallized out. The product was filtered and recrystallized from 80 mL ethanol. Yield 6.91 grams 72%. B: The filtrate was extracted with water. The organic phase was evaporated down to a small volume to which was added 1.43 gr (11.5 mmole) fumărie acid with 120 mL ethanol. The reactants were heated to boiling. The heating was stopped and the Quetiapine hemifumarate crystallized out. The product were continued to ştir, filtered and recrystallized from 70 mL ethauol. Yield 6.36 grams (65.5%) C: To the filtrate was added 1.43 gr (l 1.5 mmole) fumărie acid. It was heated in a boiling water bath, removed from the bath and let to ştir. The Quetiapine hemifumarate crystallized out. The product v/as filtered and recrystallized from 90 mL ethanol. Yield 7.12 grams (73.3%). D: The filtrate was concentrated down to a small volume, l .433 gr (l 1.5 mmole) fumărie acid was added with 120 mL ethanol. The mixture was heated to boiling, and removed from the heating bath. The Quetiapine hemifumarate crystallized out and was cooled, filtered and recrystallized fi-om 70 mL ethanol. Yield 6.62 grams (68.1). Example 5 (Comparative) Reagents: 11-piperazinyl dibenzo{b,fj[l,4] thiazepinehydrochloride 2,75 gr (7.5 mmole) 2-(2-Chloroetboxy) ethanol 1.2 gr (9.6 mmole) Na2CO3 4.75 gr Nai 40-50 mg Toluene 15 mL Procedure: The reagents were charged to a round-bottomed flask equipped with a magnetic stirrer and a condenser with a calcium chloride drying tube. The flask and contents were heated in an oii bath at 115°C -120°C under gentle reflux. The progress of the reaction was checked by HPLC after 17 hours and Ihe contents of the flask contained 91.6% product and 7.1% starting material. Example 6 Reagents: 11-piperazinyl dibenzo{b,f][l,4] thiazepinehydrochloride 2.75 gr (7.5 mmole) 2-(2-Chloroethoxy) ethanol 1.2 gr (9.6 mmole) Na2C03 4.75 gr Nai 40-50 mg Toluene 15 mL TBAB 0.5 grams Procedure: The reagents were charged to a round-bottomed flask equipped with a magnetic stirrer and a condenser with a calcium chloride drying tube. The flask and contents were heated on an oii bath at 115°C -120°C under gentle reflux. After 17 hours the progress of the reaction was checked by HPLC analysis of the contents of the flask which were found to include 98.2% product and 0.45% startmg material. Example 7 (Comparative) Reagents: 11 -piperazinyl dibenzo[&,/][l,4] thiazepine hydrochloride 2.75 gr (7.5 mmole) 2-(2-Chloroethoxy) ethanol 1.2 gr (9.6 mmole) Na2CO3 4.75 gr Nai 40-50 mg n-Butanol 15mL Procedure: The reactants were charged to a round-bottomed flask equipped with a magnetic stirrer and a condenser with a calcium chloride drying tube. The flask and contents heated in an oii bath at 115°C -120°C under gentle reflux. After 17 hours, HPLC analysis showed the contents of the flask to include 94.1% product and 4.3% startmg material. Example 8 Reagents: 11-piperazinyl dibenzo[6l/][l,4] thiazepine hydrochloride 2.75 gr (7.5 mmole) 2-(2-Chloroethoxy) ethanol 1.2 gr (9.6 mmole) Na2CO3 4.75 gr Nai 40-50 mg n-Butanol 15 mL TBAB 0.5 gr Procedure: The reagents vvere charged to a round-bottomed flask equipped with a magnetic stirrer and a condenser with a calcium cnloride drying tube. The flask and contents were heated on an oii bath at 115°C -120°C with gentle reflux of the contents of the flask. After 17 hours, HPLC analysis of the contents of the flask showed 96.9% product and 0.79% starting material. Example 9 (Comparative) Reagents: 11-piperazinyl dibenzo[ij/][l,4] thiazepinehydrochloride2.75 gr (7.5 mmole) 2-(2-Chloroethoxy) ethanol 1.2 gr (9.6 mmole) Na2CO3 4.75 gr Nai 40-50 mg DMFlOmL Procedure: The reagents were charged to a round-bottonied flask equipped with a magnetic stirrer and a condenser with a calcium chloride drying tube. The flask and contents were heated in an oii bath at 103°C. After 4 hours, HPLC analysis of the contents of the flask showed 73.8% product and 25.6% starting material. After 18 hours, HPLC analysis showed 95.4% product and 1.1% starting material. [Inventors,please confirm the 95.4% afler 18 hours with no TBÂB] Example 10 Reagents: 11-piperazinyl dibenzo[b^][l,4] thiazepinehydrochloride 2.75 gr (7.5 mmole) 2-(2-Chloroethoxy) ethanol 1.2 gr (9.6 mmole) Na2C03 4.75 gr Nai 40-50 mg DMFlOmL TBAB 0.5 gr. Procedure: The reagents were charged to a round-bottomed flask equipped with a magnetic stirrer and a condenser with a calcium chloride drying tube. The flask and contents were heated in an oiî bath at 103°C. After 4 hours, HPLC analysis of the contents of the flask showed 89.7% product and 9.7% starting materia]. After 18 hours, HPLC analysis showed 95.5% product and 0.26% starting material. Exampiell A. Preparatioa of crude QTP hemifumarate A 100 liter reactor equipped with mechanical stirrer, condenser, and thermometer, was charged with n-BuOH (40.5 L), 11-piperazinyl âibenzo[bj][l,4] thiazepinehydrochloride (15 kg), Na2CO3 (7.5 kg), TBAB (l .5kg) and 2-(2-chloroeihoxy)ethanol (5.25 L). The mixture was heated to 115°C during whic time a portion of the n-BuOH and water distilled out. The distillation was continued until all of the theoretical amount of water was distilled out and the vapor temperature dropped. The reaction mixture was stirred at a rate of 120 rpm. The temperature was maintained for 26.5 hours until completion of the reaction. The reaction mixture was cooled to 25°C during 3 hours. The mixture was filtered on a filter press. The f Urate was filtered into another 160 liter reactor (5ji and l p, fîlters), equipped with mechanical stirrer, condenser, and thermometer. To the filtrate, 2.24 kg of fumărie acid was added, The resulting mixture was heated to 100°C over 2 hours and then cooled to 5°C over 2 hours. The mixture was maintained at this temperature, with stining, for an additional one hour. The resulting slurry was separated on a centrifuge and washed with n-BuOH (SOL) and ethanol absolute (SOL) to obtain 16.7 kg of wet, crude quetiapine fumarate. B. Recrystallization of crude QTP bemifamarate from ethanol. A 100 liter reactor equipped with mechanical stirrer, condenser, and thermometer, was charged with the wet material obtained as above (5.9 kg) and with ethanol absolute (80 L). The mixture was then heated to reflux (80°C) and stirred at a rate of 120 rpm. The heating was continued for 2 hours. A clear solution was obtained. The clear solution was filtered through a-5,3,0,2-micron fîler. The filtrate was then transferred to a preheated 160 liter reactor equipped with mechanical stirrer, condenser, and thermometer. The clear solution was reheated to reflux (80°C) and stirred at a rjate of 120 rpm. The heating was continued for l hour until a clear solution was obtained. The clear solution was cooled to 10°C duririg 12 hours and maintained at this tetnperature for another 5 hours. The resulting slurry was separated on a centrifuge and washed with ethanol absolute (10L) to obtam 4.3 kg of wet quetiapirie fumarate cryst. A portion of the wet material was pecked into a stirred drier and dried at 65°C, 60mmHg at a rate of 12 rpm for 5 hours. We claim: 1. A process for synthesis quetiapine and in particular, hemifumarate salt thereof comprising the step of reacting 11-piperazinyl dibenzo[b.f]-[1,4], thiazepine hydrochloride and 2-(2-chloroethoxy)ethanol in a solvent in the presence of a base, and a phase transfer catalyst selected from the group consisting of tetrabutylammonium bromide, triethylbenzylammonium chloride, tricetylmethyloammonium chloride, and tetrabutylammonium hydroxide. 2. The process as claimed in claim 1 wherein the reacting is at reflux temperature. 3. The process as claimed in any claims 1 and 2 wherein the reacting is performed in the presence of an alkali metal halide. 4. The process as claimed in claim 3 wherein said alkali metal halide is sodium iodide. 5. The process as claimed in claim 1 wherein the phase transfer catalyst is tetrabutylammonium bromide. 6. The process as claimed in any preceding claim wherein the solvent is a lower alkanol, an aromatic hydrocarbon, or dipolar aprotic solvent, or a mixture of one or more of these. 7. The process as claimed in claim 6 wherein the solvent is selected from the group consisting of -butanol, toluene and dimethyl formamide. 8. The process as claimed in any preceding claim wherein the inorganic base is selected from the group consisting of alkali metal and alkaline earth metal oxides, hydroxides, bicarbonates and carbonates. 9. The process as claimed in claim 9 wherein said inorganic base is sodium carbonate. 10 A process for making quetiapine hemifumarate as claimed in claim 1 comprising the steps of: a) reacting 11-piperazinyl dibenzo[b.f]-[1,4], thiazepine hydrochloride and 2 (2- chloroethoxy)ethanol in a solvent in the presence of an inorganic base, and a phase transfer catalyst, whereby a first slurry is obtained, b) separating the solid from the first slurry whereby a liquid filtrate is obtained, c) combining the liquid filtrate with fumaric acid, whereby a second slurry is obtained, and d) isolating quetiapine hemifumarate from the second slurry. 11. The process as claimed in claim 10 wherein the combination of step c) is heated to a temperature of 80°C to 100° C or higher and subsequently cooled to a temperature less than 100° C, whereby a slurry is obtained. 12. The process as claimed in either of claims 10 or 11 wherein the reacting is at a temperature of about 100°C. 13. The process as claimed in any of claims 10 to 12 wherein the reacting is performed in the presence of an alkali metal halide. 14. The process as claimed in claim 13 wherein said alkali metal halide is sodium iodide. 15. The process as claimed in any of claims 10 to 14 wherein the phase transfer catalyst is selected from the group consisting of tetrabutylammonium bromide' triethylbenzylarnmonium chlorides Aliquot 336' and tetrabutylammonium hydroxide. 16. The process as claimed in claim 15 wherein the phase transfer catalyst is tetrabutylammonium bromide. 17. The process as claimed in any of claims 10 to 16 wherein the solvent is a lower alkanol, an lo aromatic hydrocarbon, or dipolar aprotic solvent, or a mixture of one or more of these. 18. The process as claimed in claim 17 wherein the solvent is selected from the group comprising of n-butanol, toluene and dimethyl formamide. 19. The process as claimed in any of claims 10 to 18 wherein the base is selected Tom the group consisting of an alkali metal and alkaline earth metal oxides, hydroxides, bicarbonates and carbonates. 20. The process as claimed in claim 19 wherein the base is sodium carbonate. 21. The process as claimed in claim 10 comprising the step of recrystallizing the isolated quetiapine hemifumarate from a solvent selected from the lower alkanols and mixtures of water with a dipolar aprotic solvent. 22. The process as claimed in claim 21 wherein the lower alkanol is ethanol. 23. The process as claimed in claim 21 wherein the dipolar aprotic solvent is dimethyl formamide. 24. The process as claimed in claim 10 comprising the steps of: a) 11-piperazinyl dibenzo[b.f]-[1,4], thiazepine hydrochloride and 2-(2-chloroethoxy)ethanol is reacted at reflux in a solvent selected from n-butanol, toluene' and dimethyl formamide, wherein the base is sodium carbonate and the phase transfer catalyst is tetrabutyl ammonium bromide' and whereby the combination of step ( c) is further heated to a temperature of 100°C or higher, and subsequent cooled to 25. The process as claimed in claim 24 wherein the reaction is carried-out also in the presence of sodium iodide. 26. The process as claimed in any of claims 10, 24 or 25 comprising the step of recrystallizing the quetiapine hemifumarate isolated in step d) from a solvent that is a lower alkanol or a mixture of water and a dipolar aprotic solvent. 27. The process as claimed in 26 wherein the lower alkanol is ethanol.

Documents:

3630-DELNP-2005-Abstract-(17-02-2009).pdf

3630-delnp-2005-abstract.pdf

3630-DELNP-2005-Claims-(04-03-2009).pdf

3630-DELNP-2005-Claims-(17-02-2009).pdf

3630-delnp-2005-claims.pdf

3630-delnp-2005-complete specification (granted).pdf

3630-DELNP-2005-Correspondence-Others-(04-03-2009).pdf

3630-DELNP-2005-Correspondence-Others-(10-03-2008).pdf

3630-DELNP-2005-Correspondence-Others-(17-02-2009).pdf

3630-DELNP-2005-Correspondence-Others-(18-02-2009).pdf

3630-DELNP-2005-Correspondence-Others-(22-09-2008).pdf

3630-DELNP-2005-Correspondence-Others-(27-02-2009).pdf

3630-delnp-2005-correspondence-others.pdf

3630-delnp-2005-description (complete).pdf

3630-DELNP-2005-Form-1-(17-02-2009).pdf

3630-delnp-2005-form-1.pdf

3630-delnp-2005-form-13-(10-03-2008).pdf

3630-delnp-2005-form-18.pdf

3630-DELNP-2005-Form-2-(17-02-2009).pdf

3630-delnp-2005-form-2.pdf

3630-DELNP-2005-Form-3-(22-09-2008).pdf

3630-delnp-2005-form-3.pdf

3630-delnp-2005-form-5.pdf

3630-DELNP-2005-GPA-(27-02-2009).pdf

3630-delnp-2005-gpa.pdf

3630-delnp-2005-pct-101.pdf

3630-delnp-2005-pct-210.pdf

3630-delnp-2005-pct-220.pdf

3630-delnp-2005-pct-237.pdf

3630-delnp-2005-pct-301.pdf

3630-delnp-2005-pct-304.pdf

3630-delnp-2005-pct-308.pdf

3630-DELNP-2005-Petition-137-(18-02-2009).pdf

3630-DELNP-2005-Petition-138-(18-02-2009).pdf