Title of Invention

1,3-DISUBSTITUTED AZETIDINE COMPOUNDS AND PROCESS FOR PREPARATION OF THE COMPOUNDS

Abstract

Compounds of formula la or Ib in free or salt form, wherein Ar, X<SUB>1</SUB>, X<SUB>2</SUB>, m, R<SUB>1</SUB>, Q, Y, R<SUB>2</SUB> and R<SUB>3</SUB> have the meanings as indicated in the specification, are useful for treating conditions that are mediated by CCR-3, for example an inflammatory or allergic condition, particularly an inflammatory or obstructive airways disease. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.

Full Text

V WO 2005/026113 PCTYEP2004/010260 Y is oxygen or sulf ur; R2 is hydrogen, Q-Cg-alkyl or C3-Cio-cycloalkyl and R3 is Ci-Cg-alkyI substituted by phenyl, phenoxy, acyloxy or naphthyi, or R3 is C3-Cio-cydoaIkyl optionally having a benzo group fused thereto, a heterocydic group having 5 to 11 ring atoms of which 1 to 4 are hetero atoms, phenyl or naphthyi, said phenyl, phenoxy or naphthyi groups being optionally substituted by one or more substituents selected from halogen, cyano, hydroxy, acyl, nitro, -SO2NH2, Ci-Cg-alkyl optionally substituted by Ci-C»-alkoxy, Q-Cg-haloalkyl, d-Cs-alkoxy, GrCg-haloalkoxy, Ci-Cg-alkyithio, -SO2-Ci-Cg-alkyl, Ct-C«-alkoxycarbonyi, Ci-Cj-acylainino optionally substituted on the nitrogen atom by Ci-Cg-alkyl, Ci-Cg-alkylamino, aminocarbonyl, Ci-Cg-alkylamino-carbonyl, di(Ci-Cg-alkyl)ainino, di(Ci-Cg-aIkyi)aminocarbonyl, di(Ci-Gs-alkyl)aminocarbonyl-methoxy, or R2 and R3 together with the nitrogen atom to which they are attached denote a heterocyclic group having 5 to 10 ring atoms of which 1,2 or 3 are hetero atoms; R4 and R5 are each independently hydrogen or Ci-Cg-alkyi, or R4 is hydrogen and R5 is hydroxy-Ci-O-alkyi, acyl, -SO2R1 or -CON(R^)R7, or R4 and R5 together with die nitrogen atom to which they are attached denote a 5-or 6-membered heterocyclic group; R6 and R7 are each independently hydrogen or Ci-C*-alkyl, or R* and R7 together with the nitrogen atom to which they are attached denote a 5- or 6-membered heterocydic group; and Rs is Ci-Ct-alkyi, Q-Cg-haloalkyl, or phenyl optionally substituted by Ci-Cg-alkyl. Terms used in the specification have the following meanings: "Ci-Cg-alkyl* as used herein denotes straight chain or branched alkyi having 1 to 8 carbon atoms. Preferably, Ci-Cg-alkyl is Ci-Q-alkyl. "Ci-O-alkylene* as used herein denotes straight chain or branched alkylene that contains 1 to 8 carbon atoms. Preferably, Ci-Cg-alkylene is Ci-Q-alkylene, especially straight chain butylene. WO 2005/026113 PCT/EP2004/010260 aC3-Cio-cycloalkylw as used herein denotes cycloalkyl having 3 to 10 ring carbon atoms, for example a monocyclic group such as a cyclopropyl, cydobutyl, cyclopentyl, cydohexyi, cycloheptyl, cyclooctyl, cydononyl or cydodecyl, any of which can be substituted by one or more, usually one or two, Ci-Gj-alkyl groups, or a bicydic group such as bicydoheptyl or bicydooctyL Preferably C3-Cio-cydoalkyl is C3-C6-cycloalkyl, especially cydopropyl or cyclobutyl. "Ci-Cs-alkoxy" as used herein denotes straight chain or branched alkoxy having 1 to 8 carbon atoms. Preferably, Ci-Cg-alkoxy is d-CU-alkoxy. "Ci-Cg-haloalkyl" as used herein denotes Ci-C«-alkyi as hereinbefore defined substituted by one or more halogen atoms, preferably one, two or three halogen atoms. "Ci-C8-haloalkoxy* as used herein denotes Ci-Cg-alkoxy as hereinbefore defined substituted by one or more halogen atoms, preferably one, two or three halogen atoms. "Aminocarbonyl" as used herein denotes amino attached through the nitrogen atom to a carbonyi group. *Ci-Ci-alkylamino" and "difCi-Cg-alkylJamino11 as used herein denote amino substituted respectively by one or two Ci-Cg-alkyi groups as hereinbefore defined, which may be the same or different. Preferably Ci-Cg-alkylamino and di(Ci-Cg-alkyl)amino are respectively C1-C4-alkylamino and di(Ci-C4-aIkyl)amino. "Ci-Cii-alkylaminocarbonyl11 and Mi(Ci-Cg-aikyi)aminocarbonyl" as used herein denote aminocarbonyl as hereinbefore defined substituted respectivdy on the nitrogen atom by one or two Ci-C8-alkyl groups as hereinbefore defined, which may be the same or different. Preferably Ci-O-alkylaminocarbonyi and di(Ci-Cg-alkyi)aminocarbonyl are respectively Ci-Gt-alkyl-aminocarbonyl and di(Ci-C4-alkyl)aniinocarbonyL "Ci-Cg-alkylthio*5 as used herein denotes Ci-Cs-alkyl as hereinbefore defined linked to -S-. u Acyl" as used herein denotes alkylcarbonyl, for example Ci-Cg-alkylcarbonyl where Q-Cg-alkyl may be one of the Ci-Cg-alkyl groups hereinbefore mentioned, optionally substituted by one or more halogen atoms; cycloalkylcarbonyl, for example C3-Cg-cycloalkylcarbonyl where WO 2005/026113 PCT/EP2004/010260 C3-C8-cycloalkyl may be, for example, cydopropyl, cydobutjd, cyclopentjd, cyclohexyl, cydoheptyi or cyclooctyl; 5- or 6- membered heterocydyicarbonyi having one or two hetero atoms selected from nitrogen, oxygen and sulfur in the ring, such as furylcarbonyl or pyridylcarbonyl; aryicarbonyi, for example Q-Cio-arylcarbonyl sudi as benzoyl; or aralkylcarbonyl, for example C* to Cio-aryl-Ci-Q-alkyicarbonyl such as benzylcarbonyl or phenyiethylcarbonyl. Preferably acyl is Ci-Q-alkylcarbonyl. "Acyloxy" as used herein denotes alkylcarbonyioxy, for example Ci-Cs-alkyicarbonyloxy where Ci-Cg-alkyl may be one of the Ci-Cs-alkyi groups hereinbefore mentioned, optionally substituted by one or more halogen atoms; cydoalkylcarbonyloxy, for example C3-Cg-cydo-alkylcarbonyloxy where C3-C*-cydoaIkyl may be, for example, cydopropyl, cydobutyl, cyclopentyl, cydohexjd, cycloheptyi or cyclooctyl; 5- or 6- membered heterocyclylcarbonyloxy having one or two hetero atoms selected from nitrogen, oxygen and sulfur in die ring, such as furylcarbonyloxy or pyridylcarbonyloxy; arylcarbonyloxy, for example Cs-Cio-arylcarbonyl-oxy such as benzoyloxy; or aralkylcarbonyloxy, for example C* to Cio-aryl-Ci-O-alkyl-carbonyloxy such as benzylcarbonyloxy or phenylethylcarbonyloxy, or aryloxyalkylcarbonyl-oxy, for example, Ce-Cio-aryloxy-Ci-Cs-alkylcarbonyloxy, any of which is optionally substituted in the aryl moiety by at least one substituent selected from Ci-C«-alkoxy, halogen, Ci-C8-alkylcarbonyl, aminosulfonyl, Ci-Cs-alkylaminosuIfonyl and di(Ci-Cs-allqd)amino-sulfonyL Preferably acyloxy is Ci-C^-alkylcarbonyloxy, or benzoyloxy or phenoxy-Ci-C4-alkylcarbonyloxy. optionally substituted in the benzene ring thereof by at least one substituent selected from Ci-Gj-alkoxy, Ci-C4-alkylcarbonyi or aminosulfonyi. u Acyiamino* as used herein denotes amino substituted by acyl as hereinbefore defined. "Halogen" as used herein may be fluorine, chlorine, bromine or iodine; preferably it is fluorine, chlorine or bromine. "Ci-Cs-alkoxycarbonyP as used herein denotes Ci-C»-alkoxy as hereinbefore defined attached through the oxygen atom to a carbonyl group, *cDi-(Ci-C8-alkyl)aminocarbonylmethoxy*' as used herein denotes aminocarbonylmethoxy disubstituted on the amino nitrogen atom by Ci-Cg-aikyl as hereinbefore defined, the two Ci-Cg-alkyi groups being the same or different WO 2005/026113 PCT/EP2004/010260 " Optionally substituted" means the group referred to can be substituted at one or more positions by any one or any combination of the radicals listed thereafter. In Ar, the phenyl group may be substituted, for example by one, two or three, preferably one or two halogen atoms, preferably selected from fluorine and chlorine atoms, or by one or two Ci-Cg-alkyl, cyano or nitro groups, or by Ci-Cs-alkyl and one or two halogen, preferably fluorine or chlorine, atoms. When there is one halogen substituent, it is preferably para to the indicated group X1 or X2. When there are two or three halogen substituents, preferably one is para to the indicated group X1 or X2 and at least one of the others is ortho to the para-halogen substituent. R3 as substituted phenyl may, for example, be substituted by one, two, three, four or five, preferably by one, two or three, of the abovementioned substituents. R3 may be, for example, phenyl substituted by one, two or three substituents selected from halogen, cyano, hydroxy, nitro, Q-Q-alkoxy, Ci-Gj-alkoxycarbonyl, Ci-Grhaloalkoxy, -CO-NH2, di(Ci-C4-alkyl)-aminocarbonylmethoxy, Ci-CU-alkyl optionally substituted by Ci-d-alkoxy, Ci-CU-haloalkyl, Ci-Q-alkylcarbonyl, Ci-Gj-aikylthio, -SO2-NH2, -SOa-Ci-Q-alkyl, di(Q-C4-alkyl)amino, Ci-CU-alkylaminocarbonyl or Ci-Q-alkyl-carbonylamino. R3 as substituted phenyl is preferably phenyl substituted by one or more substituents selected from cyano, halogen, Ci-Gralkyl optionally substituted by Q-Q-alkoxy, Ci-CValkylcarbonyi, Ci-Q-alkoxy, Q-CValkoxy-carbonyl, -CO-NH2, -SO2-NH2, -SOa-Ci-Gi-alkyl, Ct-C4-alkyl-aminocarbonyl, di(Ci-C4-alkyl)-aminocarbonyl-methoxy or Ci-CU-alkyi-carbonyiamino, especially cyanophenyl, particularly meta-cyanophenyl, and disubstituted phenyl where one substituent is Ci-C4-aikoxy or di(Ci-Gralkyijaminocarbonylmethoxy, preferably ortho to the bond linking R3 to the remainder of the molecule shown in formula la or Ib, and the other, preferably para to the Ci-CValkoxy group, is Ci-C4-alkoxy, halogen, cyano or Ci-Gralkyi. When R3 is Ci-Q-alkyl substituted by optionally substituted phenoxy, the substituent(s) on phenoxy may be, for example, one, two or three substituents selected from halogen, cyano, Ci-Gs-aHcyl, d-Ct-alkoxy or Ci-Cg-alkyl-carbonyl. R3 as a heterocyclic group may be, for example, a group having 5 to 11 ring atoms of which one, two, three or four, preferably one or two, are hetero atoms selected from nitrogen, oxygen or sulfur, such as pyrrolyi, furyl, thienyl, imidazolyl, pyrazolyi, oxazolyl, isoxazolyl, thiazolyi, thiadiazolyl, triazolyi, tetrazolyl, pyridyi, pyranyl, pyrazinyl, or a 5-, 6- or 7-membered heterocyclic, ring preferably having one or two oxygen or nitrogen ring atoms, fused to a WO 2005/026113 PCT/EP2004/010260 benzene ring, said heterocydic group being optionally substituted by substituents induding halogen, Ci-Gralkyl optionally substituted by Ci-Gj-alkoxy, Ci-CU-alkoxy, -SCb-Ci-Cs-alkyl, C3-Cio-cydoalkyl, phenyl, phenyl-Ci-C4-alkyi and C2-C4-alkynyL Preferably a heterocydic group having 5 to 11 ring atoms of which one, two, three or four, preferably one or two, are hetero atoms selected from nitrogen, oxygen or sulphur is a heterocydic group having 5, 6 or 7 ring atoms of which one, two, three or four, are hetero atoms selected from nitrogen, oxygen and sulphur- It is espedally preferred that the heterocydic group is thiadiazolyl, pyrazolyl, tetrazolyl or isoxazolyl, optionally substituted by one or more of Ci-Gj-alkyl, d-O-alkoxy and C3-C6-cycloalkyl. R2 and R3 together with the nitrogen atom to which they are attached as a heterocydic group may be, for example, a group having a 5* or 6-membered ring of which one, two or three are heteroatoms, optionally fused to a benzene ring, such as thiadiazolyl, pyrazolyl, tetrazolyl, piperidinyl, piperazinyl, morpholino, or benzopiperidinyl, optionally substituted by one or more substituents including Ci-Cg-alkyl, Ci-Cj-alkoxy, C3-Cio-cydoalkyl and halogen. R1 as optionally substituted Ci-Cj-alkyl is preferably optionally substituted Ci-CValkyI, espedally Ci-Gt-alkyl or substituted methyl or ethyl. When R1 is substituted by a cyclic organic group, the latter may be a carbocyclic or heterocydic group, for example a C3-Ci5-carbocyclic group or a 5- to 7-membered heterocydic group having one or more, preferably one, two or three, ring hetero atoms selected from nitrogen, oxygen and sulfur. Hie C3-Ci5-carbocydic group may be, for example, a cydoaliphatic group having 3 to 8 carbon atoms, preferably a Ci-Q-cycloalkyl such as cyclopentyl, methylcydopentyl or cydohexyL The C3-Ci5-carbocydic group may alternatively be, for example, a Cs-Cu aromatic group, such as phenyl, which is unsubstituted or substituted by Ci-Cs-alkyl, Ci-Cs-alkoxy, halogen, cyano, -CON(R4)R5, -SC>2N(R4)R5 or Ci-C«-alkyisulfonylamino where R4 and R5 are as hereinbefore defined. The heterocydic group may have one nitrogen, oxygen or sulfur atom in the ring or it may have two nitrogens, or one oxygen and one or two nitrogens, or one sulfur and one or two nitrogens in the ring. The heterocydic group is preferably a heterocyclic aromatic group, espedally a 5-or 6- membered heterocyclic group such as furyl, imidazolyi, thiazolyl or pyridyl. Preferred embodiments indude those in which R1 is hydrogen or Ci-CU-alkyl substituted by hydroxy or Ci-Q-alkoxy. Throughout this spedfication and in the claims that follow, unless the context requires otherwise, the word "comprise", or variations such as "comprises" or "comprising", will be WO 2005/026113 PCT/EP2004/010260 R3 is a heterocyclic group having 5, 6 or 7 ring atoms of which one, two, three or four, are hetero atoms selected from nitrogen, oxygen and sulphur, said heterocyclic group being optionally substituted by Ci-Q-alky, CrO-alkoxy or C3-C$-cycloalkyi; or (ii) compounds of formula Ib in free or salt form, wherein AT is phenyl substituted by halo, preferably chloro; X2 is -O-, -C(=O)- or -CH2-; rn is 1 or 2; Q has the formula where Ra is Ci-Q-alkjdene, or Q is -C(Rb)(Rc)- where Rb and Rc are independently Ci-Q-alkyi or Rb and Rc together form a C3-CVcycloalkyl; R2 is hydrogen; and R3 is a heterocyclic group having 5, 6 or 7 ring atoms of which one, two, three or four, are hetero atoms selected from nitrogen, oxygen and sulphur, said heterocyclic group being optionally substituted by Ci-CU-alkyi or Cs-Ce-cydoalkyl. The compounds represented by formula la or Ib are capable of forming add addition salts, addition salts of the compounds of formula la or Ib include those of inorganic acids, for example, hydrohalic acids such as hydrofluoric acid, hydrochloric acid, hydrobromic acid or hydroiodic acid, nitric acid, sulfuric acid, phosphoric acid; and organic acids, for example aliphatic monocarboxylic acids such as formic acid, acetic acid, trifluoroacetic acid, propionic acid and butyric acid, aliphatic hydroxy acids such as lactic acid, citric add, tartaric add or malic acid, dicarboxylic adds such as maleic add or succinic add, aromatic carboxyiic adds such as benzoic acid, p-chlorobenzoic add, diphenyiacetic add or triphenylacetic add, aromatic hydroxy adds such as o-hydroxybenzoic add, p-hydroxj^)enzoic add, 1-hydroxynaphthalene-2-carboxylic add or 3-hydroxynaphthalene-2-carboxylic add, and sulfonic adds such as xnethanesulfonic add or benzenesulfonic add. These salts may be prepared from compounds of formula la or Ib by known salt-forming procedures. Compounds of formula la or Ib which contain addic, e.g. carboxyl, groups, are also capable of forming salts with bases, in particular phannaceutically acceptable bases such as those well known in the art; suitable such salts include metal salts, particularly alkali metal or alkaline WO 2005/026113 PCT/EP2004/010260 earth metal salts such as sodium, potassium, magnesium or calcium salts, or salts with ammonia or pharmaceutically acceptable organic amines or heterocyclic bases such as ethanolamines, benzylamines or pyridine. These salts may be prepared from compounds of formula la or Ib by known salt-forming procedures. When R1 is other than hydrogen, the carbon atom to which R1 is attached in formula la is asymmetric, in which case the compounds exist in individual optically active isomeric forms or as mixtures thereof, e.g. as racemic or diastereomeric mixtures. When X1 is -S(=O), the sulfur atom is asymmetric, so again the compounds exist in individual optically active isomeric forms or as mixtures thereof, e.g. as racemic or diastereomeric mixtures. In both cases the invention embraces both individual optically active R and S isomers as well as mixtures, e-g. racemic or diastereomeric mixtures, thereof. When Q has the formula where Ra is Ci-Q-alkylene the compounds can exist in individual optically active isomeric forms or as mixtures thereof, e.g. as racemic or diastereomeric mixtures. When X2 is -S(=O), the sulfur atom is asymmetric, so again the compounds exist in individual optically active isomeric forms or as mixtures thereof, e.g. as racemic or diastereomeric mixtures. In both cases the invention embraces both individual optically active R and S isomers as well as mixtures, e.g. racemic or diastereomeric mixtures, thereof. Specific especially preferred compounds of the invention are those described hereinafter in the Examples. The invention also provides a process for the preparation of compounds of formulae la or Ib which comprises (i) (A) for the preparation of compounds of formula la where R2 is hydrogen, reacting a compound of formula Ha WO 2005/026113 PCT/EP2004/010260 (ii) recovering the product in free or salt form. Process variant (A) may be effected using known procedures for reaction of amines with isocyanates or analogously e.g. as hereinafter described in the Examples. The reaction is conveniendy carried out in an organic solvent, for example a halohydrocarbon such as dichloromethane (DCM) or an ether such as dioxane. The reaction temperature may be e.g. from 0 °C to 10ft °C, conveniendy ambient temperature. Process variant (B) may be effected using known procedures for reaction of amines with carbamic acid phenyi esters or analogously e.g. as hereinafter described in the Examples. The reaction is conveniendy carried out in an organic solvent such as dimethyl sulfoxide (DMSO). The reaction temperature may be e.g. from 20 to 100 °C, conveniendy ambient temperature. Process variant (C) may be effected using known procedures for oxidising sulfanyl groups to form sulfonyl groups or analogously e.g. as hereinafter described in the Examples. The oxidising agent used is preferably a perbenzoic acid, especially meta chloro-per-benzoic acid. Hie reaction is conveniendy carried out in an organic solvent such as dichloromethane (DCM). The reaction temperature may be e.g. from 5 to 25 °C, preferably about 15 °C. Process variant (D) may be effected using known procedures for reaction of amines with carbamic acid phenyi esters or analogously e.g. as hereinafter described in the Examples. The reaction is conveniendy carried out in an organic solvent such as dimethyl sulfoxide (DMSO). The reaction temperature may be eg, from 20 to 100 °C, conveniendy ambient temperature. Process variant (E) may be effected using known procedures for reaction of amines with isocyanates or analogously e.g. as hereinafter described in the Examples. The reaction is conveniendy carried out in an organic solvent, for example a halohydrocarbon such as dichloromethane (DCM) or an ether such as dioxane. The reaction temperature may be e,g. from 0 °C to 100 °C, conveniendy ambient temperature. Process variant (F) may be effected using known procedures for oxidising sulfanyl groups to form sulfonyl groups or analogously e.g. as hereinafter described in the Examples. The oxidising agent used is preferably a perbenzoic acid, especially meta chloro-per-benzoic acid. Hie reaction is conveniendy carried out in an organic solvent such as dichloromethane (DCM). The reaction temperature may be e.g. from 5 to 25 °C, preferably about 15 °C. WO 2005/026113 PCT/EP2004/010260 of formulae VIE and X may be effected using known methods, for example in the presence of a tertiary organic base such as triethylamine or l,8-diazabicydo-[5.4.0]-iindec-7-ene (DBU), conveniendy in an inert organic solvent, for example a polar solvent such as dimethylformamide, the reaction temperature suitably being from 0 to 40°C, preferably ambient temperature. Replacement of a protective group R* by hydrogen may be effected using known procedures; for example, where R9 is tert-butoxy-carbonyi, by treatment with a carboxyiic acid such as trifluoroacetic acid. Replacement of a protecting group in R1 may be affected using known procedures, for example, when R1 contains a hydroxy group protected as an ether group, such as tert-butoxy, by treatment with HBr in a carboxyiic acid such as acetic acid; when R9 is a protective group, this treatment also replaces R* by hydrogen. Compounds of formula III are commercially available or may be prepared by known methods. Compounds of formula IV or V are known or may be prepared by known procedures or analogously e.g. as hereinafter described in the Examples. Compounds of formula VI where X1 is -S- may be prepared by reacting a compound of formula XI in the presence of sodium hydride where R10 is a protecting group, and replacing R10 in the product by hydrogen, or analogously e.g. as hereinafter described in the Examples. The reaction may be carried out in an inert organic solvent such as dimethylformamide (DMF). Suitable reaction temperatures may be from 20°C to 150°C, conveniently from 50 to 70°C. The replacement of R10 by hydrogen may be effected using known procedures or analogously e.g. as hereinafter described in the Examples. Compounds of formula VI where X1 is -S(=O)- may be prepared by reacting the corresponding aryi-sulfanyl-azetidine, preferably a protected form thereof, with an oxidising agent such as a per-benzoic acid, or analogously e.g. as hereinafter described in die Examples. The reaction is conveniendy carried out in an organic solvent such as dichloromethane (DCM). The reaction temperature may be e.g. from 5 to 25 °C, preferably about 15 °C. WO 2005/026113 PCT/EP2004/010260 carried out in an inert organic solvent such as DMR Suitable reaction temperatures may be from 20°C to 150°C, conveniently from 50 to 70°C. The replacement of R12 by hydrogen may be effected using known procedures or analogously e.g. as hereinafter described in the Examples. Compounds of formula VIE where X2 is —CHr- are novel and may be prepared by reduction of compounds of formula VIII where X2 is -C(=O) —, for example using known reduction procedures or analogously e.g. as hereinafter described in the Examples. TTiis preferably involves of reduction to the corresponding alcohol, conversion to die iodine and then reduction. in the presence of sodium hydride where R13 is a protecting group, and replacing R13 in the product by hydrogen, or analogously e.g. as hereinafter described in the Examples. The reaction may be carried out in an inert organic solvent such as dimethylformamide (DMF). Suitable reaction temperatures may be from 20°C to 150°C, conveniently from 50 to 70°C. The replacement of R13 by hydrogen may be effected using known procedures or analogously e.g. as hereinafter described in the Examples. Compounds of formula VDI where X2 is -S(=O)- may be prepared by reacting the corresponding aryl-sulfanyl-azetidine, preferably a protected form thereof, with an oxidising agent such as a per-benzoic acid, or analogously e.g. as hereinafter described in the Examples. The reaction is conveniently carried out in an organic solvent such as dichloromethane (DCM). The reaction temperature may be e.g. from 5 to 25 °C, preferably about 15 °C. Compounds of formula VIE where X? is -S(=O)2- may be prepared by reacting the corresponding aryl-sulfanyl-azetidine, preferably a protected form thereof, with an oxidising agent such as a per-benzoic acid, or analogously e.g. as hereinafter described in the Examples. WO 2005/026113 PCT/EP2004/010260 The reaction is conveniently carried out in an organic solvent such as dichloromethane (DCM). The reaction temperature may be e.g. from 5 to 25 °C, preferably about 15 °C Compounds of formulae DC , X, XI or XII are known or may be prepared by known procedures or analogously e.g. as hereinafter described in the Examples. Compounds of formula XIII may be prepared by reacting a compound of formula XIX where Ru is as hereinbefore defined, with O,N-dimethylhydroxjdamine hydrochloride in the presence of a peptide coupling agent such as di-imidazol-i-yl-inethanone, conveniently in an inert organic solvent such as THF, suitably at reflux temperature, or analogously e.g. as hereinafter described in the Examples. Compounds of formula XIV, XV, XVI, XVII, XVIII or XIX are known or may be prepared by known procedures or analogously e.g. as hereinafter described in the Examples. Where reference is made herein to protected functional groups or to protecting groups, the protecting groups may be chosen in accordance with the nature of the functional group, for example as described in Protective Groups in Organic Synthesis, T. W, Greene, P.GJVL Wuts, John Wiley &c Sons Inc, Third Edition, 1999, which reference also describes procedures suitable for replacement of the protecting groups by hydrogen. Compounds of formula la or Ib in free form may be converted into salt form, and vice versa, in a conventional manner. The compounds in free or salt form can be obtained in the form of hydrates or solvates containing a solvent used for crystallization. Compounds of formula la or Ib can be recovered from reaction mixtures and purified in a conventional manner. Isomers, such as enantiomers, may be obtained in a conventional manner, e.g. by fractional crystallization or asymmetric synthesis from correspondingly asymmetrically substituted, e.g. optically active, starting materials. Compounds of formula la or Ib in free or pharmaceutically acceptable salt form, hereinafter referred to alternatively as agents of the invention, are useful as pharmaceuticals. Accordingly WO 2005/026113 PCT/EP2004/010260 the invention also provides a compound of formula la or Ib in free or pharmaceuticaUy acceptable salt form for use as a pharmaceutical. The agents of the invention act as CCR-3 receptor antagonists, thereby inhibiting the infiltration and activation of inflammatory cells, particularly eosinophils, and inhibiting allergic response. Tlie inhibitory properties of agents of the invention can be demonstrated in the following assay: In this assay the effect of agents of the invention on the binding of human eotaxin to human CCR-3 is determined- Recombinant cells expressing human CCR-3 are captured by wheatgerm agglutinin (WGA) polyvinyltoluidene (PVT) SPA beads (available from Amersham), through a specific interaction between the WGA and carbohydrate residues of glycoproteins on the surface of the cells. [12SI]-human eotaxin (available from Amersham) binds specifically to CCR-3 receptors bringing the ["^-human eotaxin in dose proximity to the SPA beads. Emitted a-particles from the [125I]-human eotaxin excite^ by its proximity, the fluorophore in the beads and produce light. Free [125I]-human eotaxin in solution is not in close proximity to the scintillant and hence does not produce light. The scintillation count is therefore a measure of the extent to which the test compound inhibits binding of the eotaxin to the CCR-3. Preparation of Assay Buffer: 5.96 g HEPES and 7.0 g sodium chloride are dissolved in distilled water and 1M aqueous CaCb (1 ml) and 1M aqueous MgCb (5 ml) are added. The pH is adjusted to 7.6 with NaOH and the solution made to a final volume of 1 L using distilled water. 5 g bovine serum albumin and 0.1 g sodium azide are then dissolved in the solution and the resulting buffer stored at 4°C. A Complete™ protease inhibitor cocktail tablet (available from Boehringer) is added per 50 ml of the buffer on the day of use. Preparation of Homogenisation Buffer: Tris-base (2.42 g) is dissolved in distilled water, the pH of the solution is adjusted to 7.6 with hydrochloric acid and the solution is diluted with distilled water to a final volume of 1 L The resulting buffer is stored at 4°C. A Complete™ protease inhibitor cocktail tablet is added per 50 ml of the buffer on the day of use. Preparation of membranes: Confluent rat basophil leukaemia (RBL-2H3) cells stably expressing CCR3 are removed from tissue culture flasks using enzyme-free cell dissociation buffer and resuspended in phosphate-buffered saline. The cells are centrifuged (800 g, 5 minutes), the pellet resuspended in ice-cold homogenisation buffer using 1 ml homogenisation buffer per gram of cells and incubated on ice for 30 minutes. The cells are homogenised on ice with 10 strokes in a glass mortar and pestle. The homogenate is centrifuged (800 g, 5 minutes, WO 2005/026113 PCT/EP2004/010260 4°C), the supernatant further centrifuged (48,000 g, 30 minutes, 4°C) and the pellet redissolved in Homogenisation Buffer containing 10% (v/v) glyceroL The protein content of the membrane preparation is estimated by the method of Bradford (Anal Biocbem. (1976) 72:248) and aliquots are snap frozen and stored at-80°C The assay is performed in a final volume of 250 pi per well of an Optiplate™ microplate (ex Canberra Packard). To selected wells of.the microplate are added 50 pi of solutions of a test compound in Assay Buffer containing 5 % DMSO (concentrations from 0.01 nM to 10 pM). To determine total binding, 50 pi of the Assay Buffer containing 5 % DMSO is added to other selected wells. To determine non-specific binding, 50 pi of 100 nM human eotaxin (ex R&D Systems) in Assay Buffer containing 5 % DMSO is added to further selected wells. To all wells are added 50 pi [U5I]-Human eotaxin (ex Amersham) in Assay Buffer containing 5 % DMSO at a concentration of 250 pM (to give a final concentration of 50 pM per well), 50 pi of WGA-PVT SPA beads in Assay Buffer (to give a final concentration of 1.0 mg beads per well) and 100 pi of the membrane preparation at a concentration of 100 pg protein in Assay Buffer (to give a final concentration of 10 pg protein per well). The plate is then incubated for 4 hours at room temperature. The plate is sealed using TopSeal-S™ sealing tape (ex Canberra Packard) according to the manufacturer's instructions. The resulting scintillations are counted using a Canberra Packard TopCount™ scintillation counter, each well being counted for 1 minute. The concentration of test compound at which 50% inhibition occurs (IC50) is determined from concentration-inhibition curves in a conventional manner. "The compounds of the Examples hereinbelow generally have IC50 values below 1 \xM in the above assay. For instance, the compounds of Examples 1,19,25, 31, 73, 94 and 131 have IC50 values of 0.278, 0.002, 0.820, 0.117, 0.136, 0.124 and 0.096 pM respectively. Most of the compounds of the Examples exhibit selectivity for inhibition of CCR-3 binding relative to inhibition of binding of the aipha-1 adrenergic receptor. Some of the compounds e.g. those of Example 19 and 31, are also histamine HI antagonists. The inhibitory properties of agents of the invention on binding of the alpha-1 adrenergic receptor can be determined in the following assay: Cerebral cortices from male Sprague-Dawley rats (175-200 g) are dissected and homogenised in 10 volumes of ice cold 0.32 M sucrose (containing 1 mM MgCb dihydrate and lmM WO 2005/026113 PCT/EP2004/010260 K2HPO4) widi a glass/Teflon homogeniser. The membranes are centrifuged at 1000 x g for 15 miN, the pellet discarded and the centrifugation repeated. The supernatants are pooled and centrifuged at 18,000 x g for 15 minutes. The pellet is osmotically shocked in 10 volumes of water and kept on ice for 30 minutes. The suspension is centrifuged at 39,000 x g for 20 minutes, resuspended in Krebs-Henseleit buffer pH 7.4 (1.17 mM MgSCU anhydrous, 4.69 mM KC1, 0.7 mM K2HPO4 anhydrous, 0.11 M Nad, 11 mM D-glucose and 25 mM NaHCO3) containing 20 mM Tris, and kept for 2 days at -20°C. The membranes are then thawed at 20-23°C, washed three times with Krebs-Henseleit buffer by centrifugation at 18,000 x g for 15 minutes, left overnight at 4°C and washed again three times. The final pellet is resuspended with a glass/Teflon homogeniser in 125 ml/100 membranes in die same buffer. A sample is taken to determine the protein concentration (using the Bradford Assay with gamma globulin as the standard) and the remainder aliquoted and stored at -80°C. The resulting membranes are subjected to a radioligand binding assay. The assay is conducted in triplicate using 96 well plates containing P5IJ-HEAT (Amersham) (40 pM, Ka: 58.9 ± 18.7 pM), unlabelled test compound and membrane (57.1 Jig/ml) to yield a final volume of 250 \J& (assay buffer containing 50 mM Tris-base and 0.9% (w/v) NaCl, pH 7.4). The plates are incubated at 37°C for 60 minutes, after which rapid vacuum filtration over Whatman™ GF/C 96 well filter plates is carried out. Each plate is then washed three times with 10ml of ice cold assay buffer using a Brandel Cell harvester (Gaithersburg, MD). Following drying of the plates for 3 L at 50°C, 40 \d of Microscint 20 is added to each well, the plates incubated at room temperature for a further 20 minutes and die retained radioactivity quantified in a Packard TopCountNXI™ scintillation counter. Stock solutions of test compounds are dissolved initially in 100 % DMSO and diluted with assay buffer to die required concentrations to yield 1 % (v/v) DMSO. TTie concentration of test compound at which 50% inhibition occurs (IC50) is determined from concentration-inhibition curves in a conventional manner. Having regard to their inhibition of binding of CCR-3, agents of die invention are useful in the treatment of conditions mediated by CCR-3, particularly inflammatory or allergic conditions. Treatment in accordance with the invention may be symptomatic or prophylactic Accordingly, agents of the invention are useful in die treatment of inflammatory or obstructive airways diseases, resulting, for example, in reduction of tissue damage, bronchial hyper- WO 2005/026113 PCT/EP2004/010260 reactivity, remodelling or disease progression. Inflammatory or obstructive airways diseases to which the present invention is applicable include asthma of whatever type or genesis including both intrinsic (non-allergic) asthma and extrinsic (allergic) asthma, mild asthma, moderate asthma, severe asthma, bronchitic asthma, exercise-induced asthma, occupational asthma and asthma induced following bacterial or viral infection. Treatment of asthma is also to be understood as embracing treatment of subjects, e.g. of less than 4 or 5 years of age, exhibiting wheezing symptoms and diagnosed or diagnosable as "wheezy infants*, an established patient category of major medical concern and now often identified as incipient or early-phase asthmatics. (For convenience this particular asthmatic condition is referred to as "wheezy-infant syndrome**.) Prophylactic efficacy in the treatment of asthma will be evidenced by reduced frequency or severity of symptomatic attack, e.g. of acute asthmatic or bronchoconstrictor attack, improvement in lung function or improved airways hyperreactivity. It may further be evidenced by reduced requirement for other, symptomatic therapy, Le. therapy for or intended to restrict or abort symptomatic attack when it occurs, for example anti-inflammatory (e.g. cortico-steroid) or bronchodilatory. Prophylactic benefit in asthma may in particular be apparent in subjects prone to "morning dipping". "Morning dipping" is a recognised asthmatic syndrome, common to a substantial percentage of asthmatics and characterised by asthma attack, e.g. between the hours of about 4 to 6 am, i.e. at a time normally substantially distant form any previously administered symptomatic asthma therapy. Other inflammatory or obstructive airways diseases and conditions to which the present invention is applicable include acute lung injury (ALI), acute/adult respiratory distress syndrome (ARDS), chronic obstructive pulmonary, airways or lung disease (COPD, CO AD or COLD), including chronic bronchitis or dyspnea associated therewith, emphysema, as well as exacerbation of airways hypenreactivity consequent to other drug therapy, in particular other inhaled drug therapy. The invention is also applicable to the treatment of bronchitis of whatever type or genesis including, e.g., acute, arachidic, catarrhal, croupus, chronic or phthinoid bronchitis. Further inflammatory or obstructive airways diseases to which the present invention is applicable include pneumoconiosis (an inflammatory, commonly occupational, disease of the lungs, frequently accompanied by airways obstruction, whether chronic or acute, and occasioned by repeated inhalation of dusts) of whatever type or genesis, including, for example, aluminosis, anthracosis, asbestosis, chalicosis, ptilosis, siderosis, silicosis, tabacosis and byssinosis. WO 2005/026113 PCTYEP2004/010260 Having regard to their anti-inflammatory activity, in particular in relation to inhibition of eosinophil activation, agents of the invention are also useful in the treatment of eosinophil related disorders, e.g. eosinophilia, in particular eosinophil related disorders of the airways (e.g. involving morbid eosinophilic infiltration of pulmonary tissues) including hyper-eosinophilia as it effects die airways and/or lungs as well as, for example, eosinophil-related disorders of the airways consequential or concomitant to Loffler's syndrome, eosinophilic pneumonia, parasitic (in particular metazoan) infestation (including tropical eosinophilia), bronchopulmonary aspergillosis, polyarteritis nodosa (including Churg-Strauss syndrome), eosinophilic granuloma and eosinophil-related disorders affecting die airways occasioned by drug-reaction. Agents of the invention are also useful in the treatment of inflammatory or allergic conditions of the skin, for example psoriasis, contact dermatitis, atopic dermatitis, alopecia areata, erythema multiforma, dermatitis herpetiformis, scleroderma, vidligo, hypersensitivity angiitis, urticaria, builous pemphigoid, lupus erythematosus, pemphisus, epidermolysis bullosa acquisita, and other inflammatory or allergic conditions of die skin. Agents of the invention may also be used for the treatment of other diseases or conditions, in particular diseases or conditions having an inflammatory component, for example, treatment of diseases and conditions of die eye such as conjunctivitis, keratoconjunctivitis sicca, and vernal conjunctivitis, diseases affecting the nose including allergic rhinitis, e.g. atrophic, chronic, or seasonal rhinitis, inflammatory conditions of the gastrointestinal tract, for example inflammatory bowel disease such as ulcerative colitis and Crohn's disease, diseases of the bone «and joints including rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis and systemic sclerosis, and other diseases such as cyctic fibrosis, pulmonary hypertension, atherosclerosis, multiple sclerosis, diabetes (type I), myasdienia gravis, hyper IgE syndrome and acute and chronic allograft rejection, e.g. foUowing transplantation of heart, kidney, liver, lung or bone marrow. The effectiveness of an agent of the invention in inhibiting inflammatory conditions, for example in inflammatory airways diseases, may be demonstrated in an animal model, e.g. a mouse or rat model, of airways inflammation or odier inflammatory conditions, for example as described by Szarka et al,/. bmnunoL Methods (1997) 202A9-57; Renzi et al, Am. Rev. Respir. Dis. (1993) 148:932-939; Tsuyuki et aL, /. Clnu Invest. (1995) 962.924-2931; and Cernadas et al (1999) Am. /. Respir. Cell MoL Biol. 20:1-8. WO 2005/026113 PCT/EP2004/010260 The agents of the invention are also useful as co-therapeutic agents for use in combination with other drug substances such as anti-inflammatory, bronchodilatory, antihistamine or anti-tussive drug substances, particularly in the treatment of obstructive or inflammatory airways diseases such as those mentioned hereinbefore, for example as potentiators of therapeutic activity of such drugs or as a means of reducing required dosaging or potential side effects of such drugs. An agent of the invention may be mixed with the other drug substance in a fixed pharmaceutical composition or it may be administered separately, before, simultaneously with or after the other drug substance. Such anti-inflammatory drugs include steroids, in particular gluco-corticosteroids such as budesonide, bedamethasone, fluticasone, cidesonide or mometasone, or steroids described in WO 02/88167, WO 02/12266, WO 02/100879, WO 04/039827 or WO 02/00679, especially those of Examples 3,11,14,17,19, 26, 34, 37, 39, 51, 60, 67, 72, 73, 90, 99 and 101; LTB4 antagonists such as those described in US 5451700, also LY293111, CGS025019C, CP-195543, SC-53228, BIIL 284, ONO 4057 and SB 209247; LTD4 antagonists such as montelukast and zafirlukast; Dopamine receptor agonists such as cabergoline, bromocriptine, ropinu-oleand4-hydroxy-7-[2-[[2-[[3-(2-phenyleitoxy)propyl]sulfonyl3ethyl]-amino]ethyl]-2(3H)-benzothiazolone and pharmaceutically acceptable salts thereof (the hydrochloride being Viozan® - AstraZeneca); PDE4 inhibitors such as cilomilast (Ariflo® GSK), Roflumilast (Byk Gulden),V-11294A (Napp), BAY19-8004 (Bayer), SCH-351591 (Schering-Plough), Arofylline (Almirall Prodesfarma), PD189659 / PD168787 (Parke-Davis), AWD-12-281 (Asta Medica), CDC-801 (Celgene), SelCID(TM) CC-10004 (Celgene), VM554/UM565 (Vernalis), T-440 (Tanabe), KW-4490 (Kyowa Hakko Kogyo), WO 92/19594, WO 93/19749, WO 93/19750, WO 93/19751, WO 99/16766, WO 01/13953, WO 03/104204, WO 03/104205, WO 04/000814, WO 04/000839 and WO 04/005258, WO 04018450, WO 04/018451, WO 04/018457, WO 04/018465, WO 04/018431, WO 04/018449, WO 04/018450, WO 04/018451, WO 04/018457, WO 04/018465, WO 04/019944, WO 04/019945 and WO 04/045607, WO 04/037805 as well as those described in WO 98/18796 and WO 03/39544; A2a agonists such as those described in EP 409595A2, EP 1052264, EP 1241176, WO 94/17090, WO 96/02543, WO 96/02553, WO 98/28319, WO 99/24449, WO 99/24450, WO 99/24451, WO 99/38877, WO 99/41267, WO 99/67263, WO 99/67264, WO 99/67265, WO 99/67266, WO 00/23457, WO 00/77018, WO 00/78774, WO 01/23399, WO 01/27130, WO 01/27131, WO 01/60835, WO 01/94368, WO 02/00676, WO 02/22630, WO 02/96462, WO 03/086408, WO 04/039762, WO 04/039766, WO 04/045618, WO 04/046083; and A2b antagonists such as those described in WO 02/42298. WO 2005/026113 PCT/EP2004/010260 Such bronchodilatory drugs include anticholinergic or anrimuscarinic agents, in particular ipratropium bromide, oxitropium bromide, tiotropium bromide, CHF 4226 (Chiesi) and glycopyrrolate, but also those described in WO 01/04118, WO 02/51841, WO 02753564, WO 03/00840, WO 03/87094, WO 04/05285, WO 02/00652, WO 03/53966, EP 424021, US 5171744, US 3714357, US 5171744, WO 03/33495 and WO 04/018422; and beta (P)-2-adrenoceptor agonists such as albuterol (salbutamol), metaproterenoL, terbutaline, salmeterol, fenoterol, procaterol, and especially, formoterol and pharmaceutically acceptable salts thereof, and compounds (in free or salt or solvate form) of formula (I) of WO 00/75114, which document is incorporated herein by reference, preferably compounds of the Examples thereof, especially a compound of formula and pharmaceutically acceptable salts thereof, as well as compounds (in free or salt or solvate form) of formula (I) of WO 04/16601. Further suitable P -2-adrenoreceptor agonists include compounds such as those described in JP 05025045, US 2002/0055651, WO 93/18007, WO 99/64035, WO 01/42193, WO 01/83462, WO 02/066422, WO 02/070490, WO 02/076933, WO 03/24439, WO 03/72539, WO 03/42160, WO 03/91204, WO 03/42164, WO 03/99764, WO 04/11416, WO 04/16578, WO 04/22547, WO 04/32921, WO 04/33412, WO 04/37773, WO 04/37807, WO 04/39762, WO 04/39766, WO 04/45618 and WO 04/46083. Such co-therapeutic antihistamine drug substances include cetirizine hydrochloride, acetaminophen, clemastine fumarate, promethazine, loratidine, desloratidine, diphenhydramine and fexofenadine hydrochloride, activastine, astemizole, azelasdne, ebastine, epinastine, mizolastine and tefenadine as well as those disclosed in JP 2004107299, WO 03/99807 and WO 04/26841. Combinations of agents of the invention and one or more steroids, beta-2 agonists, PDE4 inhibitors or LTD4 antagonists may be used, for example, in the treatment of COPD or, particularly, asthma. Combinations of agents of die invention and anticholinergic or anrimuscarinic agents, PDE4 inhibitors, dopamine receptor agonists or LTB4 antagonists may be used, for example, in die treatment of asthma or, particularly, COPD. WO 2005/026113 PCT/EP2004/010260 Other useful combinations of agents of the invention with anti-inflammatory drugs are those with other antagonists of chemokine receptors, e.g. CCR-1, CCR-2, CCR-4, CCR-5, CCR-6, CCR-7, CCR-8, CCR-9 and CCR10, CXCR1, CXCR2, CXCR3, CXCR4, CXCR5, particularly CCR-5 antagonists such as Schering-Plough antagonists SC-351125, SCH-55700 and SCH-D, Takeda antagonists such as N-[[4-[[[6,7-dihydro-2-(4-methylphenyl)-5H-benzo-cyclohepten-8-yl]carbonyl3ammo]phenyl^ aminium chloride (TAK-770), CCR-5 antagonists described in US 6166037 (particularly claims 18 and 19), WO 00/66558 (particularly claim 8), and WO 00/66559 (particularly claim 9\ WO 04/018425 and WO 04/026873. In accordance with the foregoing, the invention also provides a method for the treatment of a condition mediated by CCR-3, for example an inflammatory or allergic condition, particularly an inflammatory or obstructive airways disease, which comprises administering to a subject, particularly a human subject, in need thereof an effective amount of a compound of formula la or Ib in a free or pharmaceutically acceptable salt form as hereinbefore described. In another aspect die invention provides the use of a compound of formula la or Ib, in free or pharmaceutically acceptable salt form, as hereinbefore described for the manufacture of a medicament for the treatment of a condition mediated by CCR-3, e.g. an inflammatory or allergic condition, particularly an inflammatory or obstructive airways disease. The agents of the invention may be administered by any appropriate route, e,g. orally, for example in the form of a tablet or capsule; parenterally, for example intravenously; by inhalation, for example in the treatment of inflammatory or obstructive airways disease; intranasally, for example in the treatment of allergic rhinitis; topically to die skin, e.g. in the treatment of atopic dermatitis; or rectally, e.g. in the treatment of inflammatory bowel disease. In a further aspect, the invention also provides a pharmaceutical composition comprising as active ingredient a compound of formula la or Ib in free or pharmaceutically acceptable salt form, optionally together with a pharmaceutically acceptable diluent or carrier therefor. The composition may contain a co-therapeutic agent such as an anti-inflammatory broachodilatory or antihistamine drug as hereinbefore described. Such compositions may be prepared using conventional diluents or excipients and techniques known in the galenic art. Thus oral dosage forms may include tablets and capsules. Formulations for topical administration may take the form of creams, ointments, gels or transdermal delivery systems, e.g. patches. Compositions WO 2005/026113 PCT/EP2004/010260 for inhalation may comprise aerosol or other atomizable formulations or dry powder formulations. When the composition comprises an aerosol formulation, it preferably contains, for example, a hydro-fluoro-alkane (HFA) propellant such as HFA134a or HFA227 or a mixture of these, and may contain one or more co-solvents known in the art such as ethanol (up to 20% by weight), and/or one or more surfactants such as oleic acid or sorbitan trioleate, and/or one or more bulking agents such as lactose. When the composition comprises a dry powder formulation, it preferably contains, for example, the compound of formula la or Ib having a particle diameter up to 10 microns, optionally together with a diluent or carrier, such as lactose, of the desired particle size distribution and a compound that helps to protect against product performance deterioration due to moisture e.g. magnesium stearate. When the composition comprises a nebulised formulation, it preferably contains, for example, the compound of formula la or Ib either dissolved, or suspended, in a vehicle containing water, a co-solvent such as ethanol or propylene glycol and a stabiliser, which may be a surfactant. The invention includes (A) an agent of the invention in inhalable form, e.g. in an aerosol or other atomisable composition or in inhalable particulate, e.g. micronised form, (B) an inhalable medicament comprising an agent of the invention in inhalable form; (C) a pharmaceutical product comprising such an agent of the invention in inhalable form in association with an inhalation device; and (D) an inhalation device containing an agent of the invention in inhalable form. Dosages of agents of the invention employed in practising the present invention will of course vary depending, for example, on the particular condition to be treated, the effect desired and the mode of administration. In general, suitable daily dosages for administration by inhalation are of the order of 0.01 to 30 mg/kg while for oral administration suitable daily doses are of the order of 0.01 to 100 mg/kg. The invention is illustrated by the following Examples. WO 2005/026113 PCT/EP2004/010260 Preparation of Intermediates f(S)-l*(tert^utyl-diphenyl-silanyloxymethyl)-3-iodo-propyl]-caAamic acid tert-butyl ester; (a) ^SV3-tert-Butoyvcarbonvlamino^-(tert-but^-diphenvl-silanyIoxy)--butyricacid benzyl ester A solution of (S)-3-tert-butoxycarbonylamino-4-hydroxy-butyric acid benzyl ester (1.34 g, 4.37 mmol) (prepared using the method of Rodriguez, Marc; Linares, Muriel; Doulut, Sylvie; Heitz, Annie; Martinez, Jean; Tetrahedron Lett. (1991), 32(7), 923-6. ) and imidazole (0.88 g, 13.01 mmol in dimethyiformamide (7 ml) is treated with tertbutyldiphenyisilyl chloride (1.69 ml, 6.5 mmol). The reaction mixture is stirred together at room temperature for 1 hour, then diluted with water and extracted into ethyl acetate. The ethyl acetate phase is dried over MgSO4and evaporated. The crude product is purified by flash silica chromatography (elution with 1:1 ethyl acetate/hexane) to afford (S)-3-tert-butoxycarbonylamino-4-(tert-butyl-diphenyl- silanyloxy)-butyric acid benzyl ester. [M-BOC] 448.0. (b) {YS)- l-(tert-Butyl-diphen\d-silanyloxvmethyl)-3-hydroxy-propyl]-carbamic acid tert-butyl ester A solution of (S)-3-tert-butoxycarbonylamino-4-(tert-butyl-diphenyl-sUanyloxy)«butyric acid benzyl ester in (2.37 g, 433 mmol) in dry diethyiether (25 ml) at 0°C is treated with a 2 M solution of lithium borohydride in THF (4.33 ml). The reaction mixture is allowed to warm to ambient temperature and stirred for 3 hours under argon, then quenched by addition of water WO 2005/026113 PCT/EP2004/010260 (10 ml) and 0.5 M aqueous citric acid solution (20 ml). The ether is separated, and the aqueous phase extracted with more ether. The combined ether phases are dried over MgSC>4 and evaporated. The crude product is purified by flash silica chromatography on a biotage column (90 g) (elution with a 1:3 ethyl acetate/hexane then methanol) to afford [(S)-l-(tert-butjd-diphenyl-silanyloxymethyl)-3-hydroxy-propyl]-carbamic acid tert-butyl ester [M-BOC] 344-1. (c) [(S)-l-(tert-Butyl-diphenyl-silanyloxymethvl)-3-iodo-propvll-carbamic acid tert-butyl ester A suspension of polystyrene resin-bound triphenylphosphine (2.33 g, 3 mmol/g) in dry dichloromethane (25 ml) is treated with iodine (1.56 g, 6.16 mmol) and stirred for 15 minutes under argon . Imidazole (0.477 g, 7.0 mmoi) is added and the reaction mixture stirred at room temperature for a further 15 minutes. The reaction mixture is then treated with a solution of [(S)-l-(tert-butyl-diphenyl-silanyloxymethyl)-3-hydroxy-propyl]-carbamic acid tert-butyl ester (1.24 g, 2.8 mmol) in dichloromethane (5 ml). The reaction mixture is refluxed for 2 hours under argon, then filtered through a Celite™ filter pad, washing with dichloromethane. The filtrate is washed with 5% aqueous sodium thiosulphate solution and water, dried over MgSO4 and evaporated. The crude product is purified by flash silica chromatography (elution with 1:99 methanol/dichloromethane) to afford [(S)-l-(tert-butyl-diphenyl-silanyloxyinethyl)-3-iodo-propylj-carbamic acid tert-butyl ester. [M-BOC] 453.9. 4(S)-3-Iodo-l-methoxvmethvl-propyl)-carbamic add tert-butyl ester: (a) (S)-3-tert-Butoxycarbonylamino-4"methoxy-butyric acid benzvl ester A solution of (S)-3-tert-butoxycarbonylamino-4-hydroxy-butyric acid benzyl ester (31.4 g, 101 mmol) (prepared using the method of Rodriguez, Marc; Linares, Muriel; Doulut, Sylvie; Heitz, Annie; Martinez, Jean ^Tetrahedron Lett. (1991), 32(7), 923-6,) in dichloromethane (280 ml) is cooled to -20°C and a 48% aqueous solution of tetrafluoroboric acid (13.3 ml, 101 mmol) added. With vigorous stirring is added dropwise a 2.0 M solution of trimethylsilyl-diazoinethane (50.8 ml, 101 mmol)) in hexane over 35 minutes. After stirring for a further 30 minutes, a second aliquot of trimethylsilyldiazomethane is added (12.7 ml, 25 mmol) slowly over 10 minutes. After stirring for a further 30 minutes at -20°C a further aliquot of trimethylsilyl-diazomethane (12.7 ml, 25 mmol) is added over 10 minutes. This pattern is continued until a total of 127 ml of trimethylsilyldiazomethane solution (254 mmol) is added. After die last addition the reaction mixture is left to stir for 1.5 hours at -20°C. The reaction mixture is then quenched with water and extracted into dichloromethane. The organic phase is dried over magnesium sulphate and evaporated. The crude product is purified by flash silica chromatography (elution with 2:8 ethylacetate / hexane) to afford (S)-3-tert-Butoxycarbonyl-amino-4-methoxy-butyric acid benzyl ester as a clear oil. [M-BOC] 224.19. WO 2005/026113 PCT/EP2004/010260 (b) ffS)-3-Hvdroxy-l-methoxymethyl-propyl)-carhamic acid tert-butyl ester A solution of (S)-3-tert-Butoxycarbonylamino-4-methoxy-butyric acid benzyl ester (10.4 g, 32.3 mmol) in dry diethylether (70 ml) cooled to 0°C is treated slowly with a 2-0 M solution of L1BH4 in *IHF (32.2 ml, 64.4 mmol). The reaction mixture is allowed to warm to ambient temperature and then left to stir. After 6 hours the reaction mixture is quenched slowly with 0.5 M aqueous solution of citric acid and extracted with ether. The ether phase is dried over magnesium sulphate and evaporated- The crude product is purified by flash silica chromato-graphy (elution with a gradient 3:7 to 6:4 ethylacetate/hexane) to afford ((S)-3-Hydroxy-l-methoxymethyl-propyl)-carbamic acid tert-butyl ester as a clear oil. [M-BOC] 120.13 (c) ((S)-3-Iodo-l-metiioxymethyl-propyl)-carbainic acid tert-butyl ester A suspension of polystyrene resin-bound triphenylphosphine (18.645 g, 3 mmol/g) in dry dichloromethane (250 ml) is treated with iodine (12.5 g, 49.22 mmol) and stirred for 15 minutes under argon . Imidazole (3.87 g, 55.94 mmol) is added and the reaction mixture stirred at room temperature for a further 15 minutes. The reaction mixture is then treated with a solution of ((S)-3-Hydroxy-l-methoxymethyl-propyl)-carbanuc acid tert-butyl ester ( 4.9 g, 22.37 mmol) in dichloromethane (30 ml), and refluxed for 1.5 hours under argon. The resin is removed by filtration through a Celite™ filter material pad, washing with dichloromethane. The filtrate is washed with 5% aqueous sodium thiosulphate solution and water, dried over MgSO4 and evaporated to afford ((S)-3-Iodo-l-methoxymethyi-propyl)-carbamic acid tert-butyl ester as a crude oil. [M-BOC] 230.06. ((RV3-iodo-l-methyl-propylV-carbamic add tert-butyl ester: (a) -3-tert-Butoxycarbonylamino-4-iodo-butyric add benzyl ester A suspension of polymer bound triphenyl phosphine (18.25 g, 54.76 mmol) in DCM (100 ml) is treated with iodine (12.2 g, 48.1 mmol) and the reaction mixture stirred at ambient temperature for 15 minutes. Imidazole (3.72 g, 54.7 mmol) is added and the reaction mixture stirred for a further 15 minutes. A solution of (S)-3-tert-butoxycarbonylamino-4-hydroxy» butyric add benzyl ester (6.76 g, 21.9 mmol) in DCM (100 ml) is added. The suspension is stirred at reflux for 1.5 hours, then filtered through Celite™ filter material, washing through with DCM. The combined organic phase is washed with an aqueous solution of 10% sodium thiosulphate, water and brine, then dried over magnesium sulphate and evaporated. The crude product is chromatographed over flash silica using 8% ethylacetate in iso-hexane as eluent to afford (S)-3-tert-butoxycarbon^amino-4-iodo-butyric add benzyl ester. [ M-BOC] 320.12 (b) ffR\-3-Hvdroxy-l-methyl-propyl)-carbamic add tert-butyl ester A solution of (S)-3-tert-butoxycarbonylaniino-4-iodo-butyric add benzyl ester (0.2 g, 0.477 WO 2005/026113 PCT/EP2004/010260 mmol) in dry diethylether (3 ml) cooled to 0°C under argon, is treated with a 2.0 M solution of lithium borohydride in THF (0.95 ml, 1.9 mmol). The reaction mixture is allowed to warm to ambient temperature with stirring for 18 hours. The reaction is quenched by addition of water and partitioned between ethylacetate and 10% citric acid solution. The organic phase is washed with brine, dried over magnesium sulphate and evaporated. The crude product is purified by flash silica chromatography using 1% methanol in DCM as eluent to afford ((R)-3-hydroxy-l-methyl-propyl)-carbamic acid tert-butyl ester, (c) ((R)-3-Iodo-l-methyl-propyl)-carbamic acid tert-butyl ester A suspension of polymer bound triphenyl phosphine (0.200 g, 0.595 mmol) in DCM (2 ml) is treated with iodine (0.133 g, 0.523 mmol) and the reaction mixture stirred at ambient temperature for 15 minutes. Imidazole (39 mg, 0.57 mmol) is added and the reaction mixture stirred for a further 15 minutes. A solution of {(R)-3-Hydroxy-l-methyl-propyl)-carbamic acid tert-butyl ester (0.045 g, 0.238 mmol) in DCM (2 ml) is added. The suspension is stirred at reflux for 2.5 hours, then filtered through Celite™ filter material, washing through with DCM. The combined organic phase is washed with an aqueous solution of 10% sodium thiosulphate, water and brine, then dried over magnesium sulphate and evaporated to afford ((R)-3-iodo-l-methyi-propyi)-carbamic acid tert-butyl ester. [ M+H] 285.05 5-Ethyl-isoxazol-3-ylamine: (a) (2-Ethvl-[1.3]dioxolan-2-vl)-acetonitrile A solution of 3-oxo-pentanenitrile (1.582 g, 16.49mmol), ethyiene glycol (1.026 ml, 84.59 mmol) and a catalytic amount of p-Toluene sulphonic acid (8 mg) in Toluene (10 ml) is refluxed at 150°C for 2 days using Dean-Stark apparatus. The reaction mixture is diluted with ethyl acetate and washed with saturated sodium bicarbonate solution. The organic phase is dried over MgSC>4, filtered, and the solvent evaporated to yield (2-ethyI-[l,3]dioxolan-2-yl)-acetonitrile. 1H NMR (400MHz, CDC13) d 4.15(2H5m), 4.05 (2H, m), 2.65 (2H, s), 1.80 (2H, q), 035 (3H, t) (b) 2-(2"Ethyl[1.3]dioxolan-2-vn-N-hvdroxv-acetamidine. A solution of NaOH (1.17 g, 29.3 mmol) in water/methanol (1:1) (1 8ml), cooled to 0°C in an ice bath, is treated with hydroxylamine hydrochloride (1.58 g, 22.78 mmol), with stirring for 5 minutes. (2-Ethyl-[l,3]dioxolan-2^)-acetonitrile (1.42 g, 10.125 mmol) is added and the reaction mixture stirred at room temperature for 18 hours, then refluxed for a further 2 hours. Hie reaction mixture is cooled and partitioned between ethyl acetate and water. The organic phase is dried over MgSO4a filtered, and the solvent evaporated to yield 2-{2-EthyI [l,3]dioxolan-2-yl)-N-hydroxy-acetamidine. [M+H] 175.21 WO 2005/026113 PCT/EP2004/010260 (c) 5-Ethvl-isoxazol-3-yIamine A solution of 2-(2-ethyl [l,3]dioxolan-2-yl)-N-hydroxy-acetamidine (1.49 g 8,564 mmol) in edxanol (49 ml), acidified to pH 1 with concentrated hydrochloric acid solution, is refluxed at 50°C for 3 days. The solvent is evaporated and the crude product dissolved in water and extracted into ethyl acetate (x2). The organic phase is dried over MgSC>4 and evaporated to afford 5-ethyl-isoxazol-3-yIamine. [M + H] 113.02 (S-Ethvl-fl.3.4^thiadiazol-2-vi\-caifaamic acid phenvl ester: A solution of 5-EthyI-[l,3,4]thiadiazol-2-yiamine (2.5g, 19.4mmol) and pyridine (1.72 ml, 21.3mmol) in dichloromethane (70 ml) is cooled to -70°C and treated with a solution of phenylchloroformate (2.45 ml, 19.6 mmol) in dichloromethane (10 ml) dropwise. The reaction mixture is allowed to warm to ambient temperature and stirred for 3 hours during which a precipitate forms. The precipitate is collected by filtration, and dried under vacuum to afford (5-Ethyl-[l,3,4]thiadiazol-2-yl)-carbamic add phenyl ester as white solid. [M+H] 250.15 (5-Cyclopropyl-2-methyl-2H-pvrazol-3-vl)-carbaiiiic acid phenvl ester: A solution of 5-CydopropyI-2-methyl-2H-pyrazol-3-ylamine (3.0 g, 22 mmol) (65 ml) and sodium bicarbonate (2 g, 24 mmol) in THF is cooled to 0°C Phenyichloroformate (3.4 g, 22 mmol) is added dropwise over 15 minutes. The reaction mixture is allowed to warm to ambient temperature and stirred for 5 hours, then filtered and the filtrate partitioned between ethyl acetate and water. The organic phase is washed with water, 5% aqueous citric acid solution and brine, dried over MgSO4 and evaporated to afford (5~Cyclopropyl-2-methyl-2H-pyrazol-3-yl)-carbamic acid phenyl ester. [M+H] 258.17. (5-Ethvl'2*methyl-2H-pyrazol-3"^)-caibamic acid phenyl ester: (a) 5-Ethyl-2-methyl-2H-pvrazol-3-vlamine A solution of 3-Oxo-pentanenitrile (0.5 g, 5.15 mmol) and methylhydrazine (0.24 g, 5.15 mmol) in ethanol (5ml) is heated to reflux for 1.5 hours. The solvent is evaporated and the residue partitioned between ethyl acetate and brine. The organic phase is dried over MgSO4 and evaporated to afford 5-Ethyl-2-methyl-2H-pyrazol-3-ylamine. [M+H] (b) /5-Ethyl-2-methvl-2H-pyrazol-3-yDH^rbamic acid phenyl ester A solution of 5-Ediyl-2-metfiyl-2H-pyrazol-3-yiamine (10 g, 79.8 mmol) (500 ml) and potassium carbonate in THF (12.14 g, 87.8 mmol) is cooled to 0°C. Phenylchloroformate (10.15 ml, 80.6 mmol) is added dropwise over 20 minutes. The reaction mixture is stirred for 40 minutes at 0°C then allowed to warm to ambient temperature and stirred for a further 2.5 WO 2005/026113 PCT/EP2004/010260 hours. The reaction mixture is partitioned between ethyl acetate and water. The organic phase is washed with 5% aqueous citric acid solution and brine. The organic phase is treated with MgSO4 and charcoal then filtered and evaporated to afford (5-Cyclopropyl-2-methyl-2H-pyrazol-3-yl)-carbamic acid phenyl ester- [M+H] 246.21 5"Cyclobutyl-2-medi^-2H-pyrazol^3*vl)-carbamic acid phenyl ester: (a) 5-Cyclobutyl-2-methyl-2H-pvrazol-3-ylamine This is synthesized in an analogous manner to 5-ethyl-2-methyl-2H-pyrazol-3-yiamine except using 3-cyclobutyI-3-oxopropionitrile instead of 3-oxo-pentanenitrile. (b) 5-Cyclobutyl-2-methyl-2H-pyrazol-3-yI)-carbamic acid phenyl ester A solution of 5-Cyclobutyl-2-methyl-2H-pyrazol-3-yIamine (0.156 g, 1.03 mmol) in dimethyl-formamide (3 ml) cooled to Q°C> is treated with phenylchloroformate (0.13 ml, 1.03 mmol) dropwise and left to stir at 0°C for 1 hour. The reaction mixture is partitioned between ethyl acetate and 1.0 M hydrochloric acid solution, and the organic phase washed with water, dried over magnesium sulphate and evaporated to yield (5-Cydobutyi-2-methyl-2H-pyrazol-3-yl)-carbamic acid phenyl ester. [M+H] 272.22 (2-Ethyl-2H-tetrazol-5-yl)-carbamic add phenyl ester; A solution of 2-ethyl-2H-tetrazol-5-ylamine (0.1 g, 0.88 mmol) in dry THF (2 ml) is treated with pyridine (0.09 ml, 1.10 mmol) followed by a solution of phenylchloroformate (0.11 ml, 0.911 mmol) in THF (1 ml). The reaction mixture is stirred at ambient temperature for 1.5 hours, then partitioned between ethyl acetate and water. The ethyl acetate phase is dried over magnesium sulphate and evaporated to afford (2-EthyI-2H-tetrazol-5-yl)-carbamic acid phenyl ester as a white solid. 1H NMR (CDC13,400 MHz) 8, 7.90 (1H, brs), 7.30 (2H, in), 7.15, (3H, m), 4.60 (2H, q) 1.60 (3H, t). (5-EthyI-isoxazol~3-yl)-carbamic acid phenyl ester and (3-Ethyl-isoxazol-5yl)-carbamic acid phenyl ester are prepared analogously using 5-Ethyl-isoxazol-3-yiamine and 5-Ethyl-isoxazol-5-ylamine respectively in place of 2-ethjd-2H-tetrazol-5-yiamine. WO 2005/026113 PCT/EP2004/010260 Preparation of final compounds l-{(S)-3-[3-(4-CMoro4>enzenesulfinyl)-azetidin^ dimethoxy-phenyi)-urea: (a) l-Benzhvdrvl-3-/4-chloro*benzenesulfinyn*azetidine A solution of l-Benzhydryl-3-(4-chloro-phenylsulfanyi)-azetidine (3.16 g, 8.6 mmol) in chloroform (30 ml) cooled to -15°C is treated slowly with a solution of meta chloro perbenzoic acid (2.17 g, 8.8 mmol) in chloroform over 2 hours. The reaction mixture is washed with water, aqueous saturated sodium bisulphate solution, sodium bicarbonate solution and brine. The organic phase is dries over magnesium sulphate and evaporated- The crude product is purified by flash silica chromatography (elution with iso-hexane: ether, 7:3 to 1:1) to afford l-Benzhydryl-3-(4-chlorobenzenesulfinyl)-azetidine, [MH]+ 384.12. (b) 3-(4-Chloro-benzenesulfinyl)-a2etidine A solution of l-Benzhydryl-3-(4-chioro-phenylsulfinyl)-azetidine (2.6g, 6.8 mmol) in dichloromethane (35 ml) cooled to -4°C, is treated with 1-chloroethoxycarbonyl chloride (1.25 ml, 11.54 mmol) and the reaction mixture allowed to warm to room temperature with stirring for 18 hours. The solvent is evaporated and the residue taken up in methanol (15 ml) and stirred at room temperature for a further 18 hours. The solvent is evaporated and the residue crystallized from methanol/diethylether to afford 3-(4-Chloro-phenylsulfinyl)-azetidine, [MH]+ 218.06 (c) {(SM-fcert-Butyl^iphenyi-sflanyloxvmeth^ propyl}-carbamic acid tert-butyl ester A solution of 3-(4-Chloro-phenyisulfinyl)-azetidine (1.17 g, 4.6 mmol), [(S)-l-(tert-Butyl-diphenyl-silanyloxymeth^)-3-iodo-propyl]-carbamic acid tert-butyl ester (2.8 g, 5.1 mmol) and trietfaylamine (2.6 ml, 18.4 mmol) in dimethyiformamide (35 ml) is stirred at ambient temperature for 18 hours. The reaction mixture is partitioned between ethyl acetate and saturated sodium bicarbonate solution. Hie organic phase is washed with water and brine, dried over magnesium sulphate and evaporated. The crude product is purified by flash silica chromatography (elution with dichloromethane: methanol, 95:5 ) to afford {{S)-l-(tert-Butyi-diphenyl-silanyloxymediyl)-3-[3-(4^Moro tert-butyl ester. [MH] + 641.29. (d) {(S)-3-[3^4-Chloro-ben2£nesulfinyl)-a2^dm^ tert-butyl ester A solution of {(S)-l-(tert-Butyl-diphenyl-siIanyloxymethyl)-3-[3--(4-chloro-phenylsulfinyl)- WO 2005/026113 PCT/EP2004/010260 stirred for 10 minutes. A solution of Methanesulfonic acid l-benzhydryl-azetidin-3-yl ester (7.27 g, 2236 mmol) in DMF (50 ml) is added and the reaction mixture left to stir at 60° C for 20 hours. The reaction mixture is portioned between ethyl acetate and water. The organic phase is washed with water (x2), dried over magnesium sulphate and evaporated. The crude product is purified by flash silica chromatography (elution with 1:4 ethylacetate/isohexane) to afford l-Benzhydryl-S-tS^dichloro-phenoxyJ-azetidine. [M+H] 383.8 (b) 3-f3.4-Dichloro-phenoxy)-azetidine hydrochloride A solution of l-Benzhydr)d-3-(3J4-dichlorO'phenoxy)-azetidine (2.14 g, 6.4 mmol) in dry dichloromethane (20 ml) is treated with 1-chloroethylchloroformate (0.832 ml, 7.7 mmol) with stirring for 4 hours. The solvent is evaporated and the residue dissolved in methanol and refluxed for 18 hrs. The tnethanoi is evaporated to a saturated solution, and then treated with diethylether. The resulting precipitate is filtered and dried under vacuum to afford 3-(3,4-Dichloro-phenoxy)-azetidine hydrochloride. 1H NMR (D6 DMSO, 400Mhz) 8 9.5 (2H, brS), 7.6 (1H, d), 7.2 (1H, s), 6.9 (1H, d), 5.1 (1H, m), 4.4 (2H, m), 3.95 (2H, m). All other substituted phenoxy azetidine hydrochloride compounds, including 3-(4-chloro-phenoxy)-azetidine hydrochloride, are made analogously if they are not readily available from commercial sources. lAy^tiHin-3-yi-(4-chloro-phenyl)-methanonehydrocMoride: (a) (l-Benzhydr)d-azetidin'3-yl>-f4-chloro-phenyH-methanone A solution of l-Benzhydryl-azetidine-3-carbonitrile (23.6 g, 95 mmol) in chlorobenzene (250 ml) under nitrogen is treated with a 1.0 M solution of 4-chlorophe,nyimagnesium bromide in diethylether (100 ml, 100 mmol) over one hour, ensuring the temperature does not exceed 30 °C. The stirred reaction mixture is heated to 60°C for 1 hour, then cooled back to ambient temperature and quenched with a saturated aqueous solution of ammonium chloride (250 ml). The organic phase is washed with brine, dried over magnesium sulphate, and evaporated to a yellow oil The oil is dissolved in methanol (300 ml), treated with concentrated hydrochloric acid (25ml), and stirred at ambient temperature for 18 hours. The solvent is evaporated and the residue partitioned between ethyl acetate (250 ml) and saturated sodium bicarbonate solution (250 ml). The aqueous phase is extracted with more ethyl acetate and the combined organic phases, treated with magnesium sulphate and charcoal, filtered and evaporated to afford (l-Benzhydry!-a2etidin-3-yl)-(4-chloro-phen)d)-methanone* [MH]+ 361.99 (b) A2etidin-3-yl-(4-chloro-phenyI)-methanone hydrochloride A solution of (l-Benzhydryl-azetidin-3-yi)-(4-chloro-phenyi)-methanone (19.8 g, 54.8 mmol) WO 2005/026113 PCT/EP2004/010260 in dichloromethane ( 250 ml), cooled to -4°Q is treated with 1-chloroethylchloroformate (8.0 ml, 73.8 mmol) and allowed to warm to ambient temperature. The reaction mixture is stirred for 18 hours and then evaporated. The residue is dissolved in methanol (220 ml) and stirred at ambient temperature for 3.5 hours. The methanol solution is concentrated and die product precipitated by addition of diethylether. The precipitate is collected by filtration and dries under high vacuum to afford Azetidin-3-yI-(4-chloro-phenyl)-methanone hydrochloride. [MH]+ 195.95. Azetidin-3-yi-(4-chloro-benzoyl)-methanone hydrochloride and all other substituted benzoyl azetidine compounds are made analogously. 3-f4-Chloro-benzylW-azetidinium trifluoroacetate salt: (a) 3-/4-ChlorO"benzoylVazetidine-l-carboxylic acid tert-butyl ester A solution of azetidin-3-yl-(4-chloro-phenyl)-methanone hydrochloride (50 g, 210 mmol) in dioxanrwater 1:1 (800 ml) is added powdered sodium bicarbonate (61.7 g, 730 mmol) and the reaction mixture cooled to 10°C. Di-tbutyi-dicarbonate (52,6 g, 240 mmol) is added portion wise and the reaction mixture allowed to warm to room temperature with stirring for 1.5 hours. The reaction mixture is poured into water (1500 ml) and the resulting white precipitate filtered off and dried under vacuum to afford 3-(4-Chloro-benzoyl)-azetidine-l-carboxylic acid tert-butyl ester. 'H NMR 400 MH7, CDCI3; S 1,45 (9H), 4,10 (1H), 4.20 (4H), 7.47 (2H), 7,80 (2H) (b) 3-ff4-ChlorO'phenyl)-hvdroxy-methyl]-azetidine-l-carboxylic acid tert-butyi ester A solution of 3-(4-Chloro-benzoyl)-azetidine-l-carboxylic acid tert-butyl ester (62.5 g, 210 mmol) in ethanol (1000 ml) cooled to 10°C is treated with sodium borohydride (9.5 g, 250 mmol). The reaction mixture is allowed to warm to room temperature and stirred for 2 hours. The reaction mixture is added to water and the precipitate collected by filtration, and dried under vacuum to afford 3-[(4-Chloro-phenjd)-hydroxy-methyi]-azetidine-l-carboxyiic acid tert-butyl ester. Mpt 123-125°C. (c) 3-[(4"Chloro-phenyl)-iodo-methyI'}-a2etidine-l-carboxylic add tert-butvl ester Polymer supported triphenylphosphine (125 g, 370 mmol) is suspended in tetrahydrofuran: acetonitrile 9:1 (1000 ml) and treated with Iodine (95.2 g, 370 mmol) followed by stirring for 15 minutes. Imidazole (25.5 g, 370 mmol) is added followed by a solution of 3-[(4-Chloro- phenyl)-hydroxy-metii^]-azetidine-l-carbox)dic acid tert-butyl ester (44.7 g, 150 mmol) in tetrahydrofuran (150 ml) and the reaction mixture stirred at ambient temperature for 20 hours. The reaction mixture is filtered through Celite™ filter material and the filtrate evaporated. The WO 2005/026113 PCT/EP2004/010260 The compounds of these Examples are prepared using procedures that are analogous to those used to prepare the compounds of Examples 94 to 100 but using the appropriate amine. Examples 115 to 98 The compounds of these Examples are prepared using procedures that are analogous to those used to prepare the compounds of Examples 31 to 37 and 52 to 58 respectively but using the appropriate starting materials. Examples 129 to 142 The compounds of these Examples are prepared using procedures that are analogous to those used to prepare the compounds of Examples 31 to 37 and 52 to 58 respectively but using the appropriate starting materials. WO 2005/026113 PCT/EP2004/010260 Ar I X I R1 1 R3 "^ f^f o i "Yjf CHa JCHj N—N Jj j ° = N 01-^^ —s— H°"" ^r ^ v^^ / : CH- Cl^^^^ —S— H0 N—O Ji ^J II ^" \ // ™3 Cl-^^^ —S— H0 O-N rPSP 8 ^ YVV i nr CH3 O^ ^ CK^^ ? ^\ // CH3 N—N ~7v I i ^ CH3 \LJ/ ^-CHa ^N. ^ O . CH, I \\ //N CH3 \i V WO 2005/026113 PCT/EP2004/010260 5. A compound according to any one of the preceding claims in combination with another drug substance which is an anti-inflammatory, a bronchodilator, an antihistamine or an anti- tussive substance. 6. A compound according to any one of the preceding claims for use as a pharmaceutical. 7. A pharmaceutical composition comprising as active ingredient a compound according to any one of claims 1 to 4. 8. The use of a compound according to any one of claims 1 to 4 for the manufacture of a medicament for the treatment of a condition mediated by CCR-3. WO 2005/026113 PCT7EP2004/010260 9. The use of a compound according to any one of claims 1 to 4 for the manufacture of a medicament for the treatment of an inflammatory or allergic condition, particularly an inflammatory or obstructive airways disease. 10. A process for die preparation of a compound of formula la or Ib as claimed in claim 1 which comprises WO 2005/026113 PCT/EP2004/010260 where Ar, X2, m and Q are as defined in claim 1, with a compound of formula IV where R2 and R3 are as defined in claim 1; (E) for the preparation of compounds of formula Ib where R2 is hydrogen, reacting a compound of formula Hb where Ar, X2, m and Q are as defined in claim 1, with a compound of formula V O=C=N—R3 V where R3 is as defined in claim 1; or (F) for the preparation of compounds of formula Ib where X is -S(=O)2-, oxidising a compound of formula Ib in protected form where X2 is -S- and Ar, m, Q, R2 and R3 are as defined in claim 1; and [ii) recovering the product in free or salt form.

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