| Title of Invention | AN INVITRO METHOD TO IDENTIFY COMPOUNDS THAT AGONIZE/ANTAGONIZE ACTIVITY OF PROTON-SENSING GPCR POLYPEPTIDES |
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| Abstract | This invention relates to an in vitro method to identity compounds that agonize or antagonize the proton-sensing activity of the a proton-sensing GPCR polypeptide as herein described comprising a method selected from the group consisting of: (a) measuring or, detecting, quantitatively or qualitatively, the binding of a candidate compound to the polypeptide (or to the cells or membranes expressing the polypeptide) or a fusion protein thereof by means of a label directly or indirectly associated with the candidate compound; (c) testing whether the candidate compound results in a signal generated by activation or inhibition of the polypeptide, using detection systems appropriate to the cells or cell membranes expressing the' polypeptide; or (d) detecting the effect of a candidate compound on the production of., mRNA encoding said polypeptide or said polypeptide in cells, using for instance, an ELISA assay. |
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3457-CHENP-2005 CORRESPONDENCE OTHERS.pdf
3457-CHENP-2005 CORRESPONDENCE PO.pdf
3457-CHENP-2005 DESCRIPTION (COMPLETE).pdf
3457-CHENP-2005 POWER OF ATTORNEY.pdf
| Patent Number | 234075 | |||||||||||||||||||||||||||
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| Indian Patent Application Number | 3457/CHENP/2005 | |||||||||||||||||||||||||||
| PG Journal Number | 22/2009 | |||||||||||||||||||||||||||
| Publication Date | 29-May-2009 | |||||||||||||||||||||||||||
| Grant Date | 05-May-2009 | |||||||||||||||||||||||||||
| Date of Filing | 20-Dec-2005 | |||||||||||||||||||||||||||
| Name of Patentee | NOVARTIS AG | |||||||||||||||||||||||||||
| Applicant Address | Lichtstrasse 35, CH-4056 Basel, | |||||||||||||||||||||||||||
Inventors:
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| PCT International Classification Number | A61K 38/17 | |||||||||||||||||||||||||||
| PCT International Application Number | PCT/EP2004/006625 | |||||||||||||||||||||||||||
| PCT International Filing date | 2004-06-18 | |||||||||||||||||||||||||||
PCT Conventions:
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