Title of Invention	AN IN VITRO METHOD FOR DETECTING A LIGAND IN A SAMPLE
Abstract	This invention relates to an in vitro method for detecting a ligand in a sample, wherein the ligand comprises a polypeptide selected from the group consisting of: (a) amino acid residues 22-205 of SEQ ID NO: 52, (b) amino acid residues 20-200 of SEQ ID NO: 55, (c) amino acid residues 22-205 of SEQ ID NO: 57, (d) amino acid residues 29-202 ofSEQ IDNO: 60, and (e) amino acid residues 29-202 of SEQ ID NO: 62; wherein said method comprises contacting the sample with a heterodimeric receptor comprising a first receptor polypeptide and a second receptor polypeptide; wherein said first receptor polypeptide comprises a sequence of amino acid residues that is at least 90% identical to: (i) amino acids 21-223 of SEQ ID NO: 2; (ii) amino acids 21-226 of SEQ ID NO: 2; (iii) amino acids 21-223 of SEQ ID NO: 19; or (iv) amino acid~ 21-226 of SEQ ID NO: 19; and wherein said first receptor polypeptide binds said ligand; and detecting binding of said ligand to said heterodimeric receptor.

Title of Invention

AN IN VITRO METHOD FOR DETECTING A LIGAND IN A SAMPLE

Abstract

This invention relates to an in vitro method for detecting a ligand in a sample, wherein the ligand comprises a polypeptide selected from the group consisting of: (a) amino acid residues 22-205 of SEQ ID NO: 52, (b) amino acid residues 20-200 of SEQ ID NO: 55, (c) amino acid residues 22-205 of SEQ ID NO: 57, (d) amino acid residues 29-202 ofSEQ IDNO: 60, and (e) amino acid residues 29-202 of SEQ ID NO: 62; wherein said method comprises contacting the sample with a heterodimeric receptor comprising a first receptor polypeptide and a second receptor polypeptide; wherein said first receptor polypeptide comprises a sequence of amino acid residues that is at least 90% identical to: (i) amino acids 21-223 of SEQ ID NO: 2; (ii) amino acids 21-226 of SEQ ID NO: 2; (iii) amino acids 21-223 of SEQ ID NO: 19; or (iv) amino acid~ 21-226 of SEQ ID NO: 19; and wherein said first receptor polypeptide binds said ligand; and detecting binding of said ligand to said heterodimeric receptor.

Full Text

Documents:

2324-CHENP-2004 ABSTRACT.pdf

2324-CHENP-2004 CLAIMS.pdf

2324-CHENP-2004 CORRESPONDENCE OTHERS.pdf

2324-CHENP-2004 CORRESPONDENCE PO.pdf

2324-CHENP-2004 DESCRIPTION (COMPLETE).pdf

2324-CHENP-2004 FORM 1.pdf

2324-CHENP-2004 FORM 18.pdf

2324-CHENP-2004 FORM 3.pdf

2324-CHENP-2004 FORM 5.pdf

2324-CHENP-2004 PCT.pdf

2324-CHENP-2004 PETITION.pdf

2324-CHENP-2004 POWER OF ATTORNEY.pdf

2324-CHENP-2004 SEQUENCE LISTING.pdf

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Patent Number

234144

Indian Patent Application Number

2324/CHENP/2004

PG Journal Number

22/2009

Publication Date

29-May-2009

Grant Date

06-May-2009

Date of Filing

13-Oct-2004

Name of Patentee

ZYMOGENETICS, INC

Applicant Address

1201 Eastlake Avenue East, Seattle, Washington 98102,

Inventors:

#	Inventor's Name	Inventor's Address
1	PRESNELL, Scott, R	2902 N. Puget Sound Ave, Tacoma, Washington 98407,
2	XU, Wenfeng	12432 54th Avenue W, Mukilteo, Washington 98115,
3	NOVAK, Julia, E	18892 Angeline Avenue, Suquamish, Washington 98392,
4	WHITMORE, Theodore, E	6916 152nd Avee NE, Redmond, WA 98052,
5	GRANT, Francis, J	7714 37th Ave NE, Seattle, WA 98115,
6	KINDSVOGEL, Wayne, R	6014 24th Ave NE, Seattle, WA 98115,
7	KLUCHER, Kevin, M	5308 135th PL SE, Bellevue, WA 98006,

PCT International Classification Number

C12N

PCT International Application Number

PCT/US2003/012030

PCT International Filing date

2003-04-18

PCT Conventions:

#	PCT Application Number	Date of Convention	Priority Country
1	60/373,813	2002-04-19	U.S.A.