Title of Invention

"A BENZOIMIDAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME"

Abstract

Disclosed herein are novel benzoimidazole derivatives functioning as antagonists to vanilloid receptor-1, and a pharmaceutical composition comprising the same. They are useful in preventing or treating pain, acute pain, chronic pain, neuropathic pain, postoperative pain, migraines, arthralgia, neuropathy, nerve injury, diabetic neuropathy, neurological illness, neurodermatitis, strokes, bladder hypersensitivity, irritable bowel syndrome, respiratory disorders such as asthma, chronic obstructive pulmonary disease, etc., burns, psoriasis, itching, vomiting, irritation of the skin, eyes, and mucous membranes, gastric-duodenal ulcers, inflammatory intestinal diseases, and inflammatory diseases.

Full Text

NOVEL BENZOIMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME Technical Field The present invention relates, in general, to novel benzoimidazole derivatives and, more particularly, to novel benzoimidazole derivatives functioning as antagonists to a vanilloid receptor (capsaicin receptor; Transient Receptor Potential Channel, Vanilloid subfamily member 1; TRPV-1; Vanilloid receptor-1; VR-1). Also, the present invention is concerned with a method for preparing the benzoimidazole derivatives, uses of the derivatives and pharmaceutical compositions comprising the derivatives as active ingredients. Background Art The vanilloid receptor, the receptor for capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide), has long been assumed to exist. Finally, it was cloned in 1997 and called vanilloid receptor subtype 1 (hereinafter referred to as "VR-1") by Caterina et al. (Caterina et al., Nature, .1997, 389, 816). Located on small unmyelinated nerve fibers (C-fibers) and myelinated nerve fibers (A-fibers), VR-1. is known as an ion channel which plays an important role in sensitizing pain stimuli by introducing the strong influx of cations such as calcium and sodium ions into the nerve endings upon activation in response to external or internal stimuli. External stimuli capable of activating VR-1 are reported to include heat and acids as well as vanilloid compounds (Tominaga et al., Neuron, 1998, 21, 531). As internal stimuli to VR-1, there are leukotriene metabolites such as 12-hydroperoxyeicosa tetraenoic acid (12-HPETE) (Hwang at al., PNAS, 2000, 97, 3655), and arachidonic acid derivatives such as anandamide (Premkumar et al., Nature, 2000, 408, 985). On the basis of these physiological activities, VR1 has attracted intensive attention as an integral controller playing a pivotal role in transferring various external injurable stimuli into nerve cells. According to a report, VRl knock-out mice responded like normal mice to general stimuli, but showed greatly reduced pain response to heat or thermal hyperalgesia, which reflects the importance of VRl against noxious stimuli (Caterina et al., Science, 2000, 288, 306). VRl is concentratively expressed in primary sensory neurons (Caterina et al., Nature, 1997, 389, 816), which are responsible for controlling functions of internal organs such as the skin, the bones, the bladder, the gastrointestinal tract, the lungs, and so on. In addition, being distributed in other neurons on the central nervous system, the kidneys, the stomach, and T-cells (Nozawa et al., Neuroscience Letter, 2001, 309, 33; Yiangou et al., Lanqet.(North America Edition), 2001, 357, 1338 ; Birder et al., PNAS, 2001, 98, 13396) and throughout the entire body, VR1 is inferred to play an important role in cell division and cellular signal control. Indications found, thus far, to be associated with the control mechanism of the activity of VR1 include pain, acute pain, chronic pain, neuropathic pain, postoperative pain, migraines, arthralgia, neuropathy, nerve injury, diabetic neuropathy, neurological illness, neurodermatitis, strokes, bladder hypersensitivity, irritable bowel syndrome, respiratory disorders such as asthma, chronic obstructive pulmonary disease, etc., irritation to the skin, eyes, and mucous membranes, itching, fever, gastric-duodenal ulcer, inflammatory intestinal diseases, and urge incontinence (Korean Pat. Laid-Open Publication No. 10-2004-0034804), and an anti-obestic effect (Pharmacol. Rev., 1986, 38, 179). Based on pharmaceutical mechanisms, both agonists and antagonists of VR1 may be used for the treatment of the above-mentioned diseases. Pain alleviating effects of VR1 agonists show the pharmaceutical mechanism based on the desensitization of capsaicin-sensitive sensory nerves. That is, VR1 agonists cause pain and irritation of sensory nerves so as to desensitize them to other noxious stimuli. Due to the induction of pain in the early stage, VR1 agonists are developed only as local analgesics. In contrast, acting through the mechanism of blocking sensory nerves from recognizing pain signals, VRl antagonists do not cause early pain or irritation, and have been studied for use in the treatment of systemic diseases. As compounds capable of modulating VRl activity, agonists such as capsaicin,. DA-5018, resiniferatoxin, etc. are used as pain drugs or are under clinical study (Szallasi, J. Med chem., 2004, 47, 2717), while 20 VRl antagonists including capsazepine and iodoresiniferatoxin are under pre-clinical study (W00208221, WO03062209, W02004055003, W02004055004, W02004002983, WO0216317, W02004035549, W02004014871, W003099284, WO03022809, •W002090326, W002072536, W003068749, W02004033435, WO02076946, W00095420, W003055484, W003014064, W003080578, W003097586, W003070247, W003029199). Featuring superior VR-1 antagonistic effects, the novel benzoimidazole derivatives according to the present invention have chemical structures different from those of the VRl antagonists reported thus far. Although the compounds included within the scope of the present invention themselves are VRl antagonists, the possibility is not excluded that modified forms thereof in an intracellular environment or metabolites thereof act as. effective principles responsible for the medicinal Disclosure of the Invention Leading to the present invention, intensive and thorough research on the modulation of the activity of VR-1, conducted by the present inventors, resulted in the finding that benzoimidazole derivatives different in chemical structure from antagonists known in the art can act as excellent antagonists having potent medicinal effects (pain and inflammation relief and anti-ulcer effect) and are accepted as highly safe from measurements in animal models. Therefore, it is an object of the present invention to provide novel benzoimidazole derivatives highly inhibitory of the activity of VR-1, or innoxious salts or solvates thereof. It is another object of the present invention to provide a method for preparing the novel benzoimidazole derivatives, or innoxious salts or solvates thereof. It is a further object of the present invention to provide pharmaceutical compositions inhibitory of the activity of VR-1, comprising the novel benzoimidazole derivatives, or innoxious salts or solvates thereof. Best Mode for Carrying Out the Invention In accordance with an aspect of the present invention, provided is a novel benzoimidazole derivative represented by the following chemical formula 1: Chemical Formula 1 wherein R1 is hydrogen; a lower alkyl having 1 to 8 carbon atoms; a lower alkenyl having 2 to 6 carbon atoms; a lower alkoxy having 1 to 8 carbon atoms; a haloalkyl having 1 to 6 carbon atoms; a haloalkoxy having 1 to 6 carbon atoms; a halogen atom; a nitro; a hydroxy; a hydroxymethyl; a cyano; an amino or amide group which is mono- or di-substituted with an alkyl having 1 to 6 carbon atoms, or is non-substituted; cycloalkyl, pyridine, pyrimidine, pyrazole, pyrazine, phenyl, benzyl, imidazole, morpholine, benzodioxole, benzothiazole, benzoimidazole, indole, pyrazolone, thiophene, furan, thiazole,, isothiazole,, oxazole, isooxazole, triazole, oxodiazole, thiadiazole, indazole, pyrrolidine, chromonyl, piperidine, morpholinethyl, dihydropyrazole or pyrrole group which is non-substituted or substituted with one1 or more Ra; or (CH2)PAr group, Each Ra is independently selected from among a lower alkyl having atoms; a lower alkenyl having 2 to 6 carbon atoms; a lower alkoxy having 1 to 8 carbon atoms; a haloalkyl having 1 to 6 carbon atoms; a haloalkoxy having 1 to 6 carbon atoms; a halogen atom; a nitro; a hydroxyl; a cyano; or an amino or amide or a sulfonamide group which is mono- or di-substituted with an alkyl having 1 to 6 carbon atoms or is non-substituted, A is 0, NH, NHCO, CO, C02, SO, S02, or NHS02, n is an integer equal to 0 or 1, W is N or CR3, X is N or CR4, R2 is hydrogen; a lower alkyl having 1 to 8 carbon atoms; a lower alkenyl having 2 to 6 carbon atoms; a lower alkoxy having 1 to 8 carbon atoms; a haloalkyl having 1 to 6 carbon atoms; a haloalkoxy having 1 to 6 carbon atoms; a halogen atom; nitro; hydroxy; hydroxymethy1; cyano; phosphoric acid; phosphateester; an amino or amide which is mono- or di-substituted with a lower alkyl having 1 to 6 carbon atoms; sulfanyl; sulfone; sulfoxide; sulfonamide; urea, carbamate, carbonate; ketone; ester; carboxylic acid; methoxyethanol group; cycloalkyl, pyridine, pyrimidine, pyrazole, pyrazine, phenyl, benzyl, imidazole, morpholine, benzodioxole, benzothiazole, benzoimidazole, indole, pyrazolone, thiophene, furan, thiazole, isothiazole, oxazole, isooxazole, triazole, oxodiazole, thiadiazole, indazole, pyrrolidine, chromonyl, piperidine, morpholinethyl, or dihydropyrazole group which is non-substituted or substituted with one or more R2, Each Rb is independently selected from among a lower alkyl having 1 to 8 carbon atoms; a lower alkenyl having 2 to 6 carbon atoms; a lower alkoxy having 1 to 8 carbon atoms; a haloalkyl having 1 to 6 carbon atoms; a haloalkoxy having 1 to 6 carbon atoms; a halogen atom; nitro; hydroxyl; cyano; sulfanyl, sulfone, sulfoxide, sulfonamide, urea, carbamate, carbonate, ketone, ester, carboxylic acid, an amino or amide which is mono- or di-substituted with a • lower alkyl having 1 to 6 carbon atoms or non-substituted, R3 and R4 may be the same or different, and are independently hydrogen; a lower alkyl having 1 to 8 carbon atoms; a lower alkenyl having 2 to 6 carbon atoms; a lower alkoxy having 1 to 6 carbon atoms; a haloalkyl having 1 to 6 carbon atoms; a haloalkoxy having 1 to 6 carbon atoms; a halogen atom; nitro; hydroxy; cyano; sulfanyl; sulfone; s*ulfoxide; sulfonamide; urea; carbamate; carbonate; ketone; ester; carboxylic acid; an amino or amide group which is mono- or di-substituted with an alkyl having 1 to 3 carbon atoms or is non-substituted; or a phenyl or benzyl group which is non-substituted or substituted with Rc, or R3 and R4 form together a saturated, partially saturated, or unsaturated 5-, 6- or 7-membered heteromonocyclic ring or a saturated, partially saturated, or unsaturated 6-, 7-, 8-, 9-, 10- or 11-membered heterobicyclic ring compound which is mono-, di-, tri- or tetra-snbstituted with a nitrogen atom, an oxygen atom or a sulfur atom, or is non-substituted, Rc is selected from among a lower alkyl having 1 to 6 carbon atoms; a lower alkenyl having 2 to 4 carbon atoms; a lower alkoxy having 1 to 6 carbon atoms; a haloalkyl having 1 1 to 6 carbon atoms; a haloalkoxy having 1 to 6 carbon atoms or a halogen atom, Q1 is N or CR6, Q2 is N or CR7, Q3 is N or CR8, Q4 is N or CR9, Ar is selected from among RIO Rl1 RIO Rn RIO Rn RIO Rn p is an integer of 0, 1, 2, 3 or 4, R6, R7, R8, and R9 may be the same or different, and are independently hydrogen; a lower alkyl having 1 to 8 carbon atoms; a lower alkenyl having 2 to 6 carbon atoms; a lower alkoxy having 1 to 8 carbon atoms; a haloalkyl having 1 to 6 carbon atoms; a haloalkoxy having 1 to 6 carbon atoms; a halogen atom; a nitro; hydroxy; hydroxymethyl; cyano; an amino or amide which is mono- or di-substituted with a lower alkyl having 1 to 6 carbon atoms or is non-substituted; sulfanyl; sulfone; sulfoxide; sulfonamide; urea; carbamate; carbonate; ketone; ester; carboxylic acid group; cycloalkyl, pyridine, pyrimidine, pyrazole, phenyl, benzyl, imidazole, morpholine, benzodioxole, benzothiazole, benzoimidazole, indole, pyrazolone, thiophene, furan, thiazole, isothiazole, oxazole, isooxazole, triazole, oxodiazole, thiadiazole, indazole, thiomorpholine, thiazolidine, oxazolidine, pyrrolidine, chromonyl, piperidine, morpholinethyl, or dihydropyrazole group which is non-substituted or substituted with one or more Rd, or any two of R6, R7, R8, and R9 form together a saturated, partially saturated or unsaturated 5-, 6- or 7-membered heteromonocyclic or a saturated, partially saturated or unsaturated 6-, 7-, 8-, 9-, 10- or 11-membered heterobicyclic ring compound which is mono-, di-, tri- or tetra-substituted with a nitrogen atom, an oxygen atom or a sulfur atom or is non-substituted, Each Rd is independently selected from among a lower alkyl having 1 to 8 carbon atoms; a lower alkenyl having 2 to 6 carbon atoms; a lower alkoxy having 1 to 8 carbon atoms; a haloalkyl having 1 to 6 carbon atoms; a haloalkoxy having 1 to 6 carbon atoms; a halogen atom; a nitro; a hydroxyl; a cyano; an amino, amide, sulfanyl, sulfone, sulfoxide, sulfonamide, urea, carbamate, carbonate, ketone, ester, or carboxylic acid which is mono- or di-substituted with a lower alkyl having 1 to 6 carbon atoms or is non-substituted, R10, R11 and R12 may be the same or different, and are independently hydrogenr a lower alkyl having 1 to 8 carbon atoms; a cycloalkyl ; a lower alkenyl having 2 to 6 carbon atoms; a lower alkoxy having 1 to 6 carbon atoms; a haloalkyl having 1 to 6 carbon atoms; a halogen atom; nitro; hydroxy; hydroxymethyl; cyano; sulfanyl; sulfone; sulfoxide; sulfonamide; urea; carbamate; carbonate; ketone; an amino, amide, carboxylic acid, or carboxyester group which is mono- or di-substituted with a lower alkyl having 1 to 3 carbon atoms or is non-substituted, or any two of R10, R11, and R12 form together a saturated or unsaturated heteromonocyclic or heterobicyclic ring compound. In a preferred embodiment, the novel benzoimidazole derivative of the present invention comprise the compounds of Chemical Formula 1 and isomers thereof, concrete examples of which include: 2-[4-(3-chloropyridin-2-yl)phenyl]-6-trifluoromethyl-1H-benzoimidazole, 6-chloro-2-[4-(3-chloropyridin-2-yl)phenyl]-1H-benzoimidazole, 6-tert-butyl-2-[4-(3-chloropyridin-2-yl)phenyl]-1H-benzoimidazole, 2-[4-(3-chloropyridin-2-yl)phenyl]-6-fluoro-1H-benzoimidazole, 2-[4_(3-chloropyridin-2-yl)phenyl]-6-methoxy-lH-benzoimidazole, 4-chloro~2~[ 4- {3-chloropyridin-2-yl)phenyl]-6-trifluoromethyl-1H-benzoimidazole, 2-[4-(3-chloropyridin-2-yl)phenyl]-4,6-bistrifluoromethyl-lH-benzoimidazole, 2- [4-(3-chloropyridin-2-yl)phenyl]-6-trifluoromethyl-1H-imidazo[4,5-b]pyridine, 2-[4-(3-chloropyridin-2-yl)phenyl]-3H-imidazo[4,5-b]pyridine, 2-[4-(3-chloropyridin-2-yl)phenyl]-6,7-dimethyl-1H-benzoimidazole, 2-[4-(3-chloropyridin-2-yl)phenyl]-1H-benzoimidazole, 2-[4-(3-chloropyridin-2-yl)phenyl]-5,6-dichloro-lH-benzoimidazole, 6-bromo-2-(4-(3-chloropyridin-2-yl)phenyl)-1H-benzoimidazole, 4-bromo-2-(4-(3-chloropyridin-2-yl)phenyl)-6-(trifluoromethyl)-1H-benzoimidazole, 6-bromo-2-(4-(3-chloropyridin-2-yl)phenyl-lH-imidazo[4,5-b]pyridine, 4,6-dibromo-2-[4-(3-chloropyridin-2-yl)phenyl]-1H-benzoimidazole, 2-[4-(3-chloropyridin-2-yl)phenyl]-6-morpholin-4-yl-1H-benzoimidazole, 2-[4-(3-chloropyridin-2-yl)phenyl]-6-thiomorpholin-4-yl-lH-benzoimidazole, 2-[4-(3-chloropyridin-2-yl)phenyl]-4-morpholin-4-yl- 6-trifluoromethyl-lH-benzcinddazole, 2-[4-(3-chloropyridin-2-yl)phenyl]-4-thiomorpholin-4-yl-6-trifluoromethyl-lH-benzoimidazole, 2-[4-(3-chloropyridin-2-yl)phenyl]-4-pyrrolidin-l-yl-6-trifluoromethyl-lH-benzoimidazole, {2-[4-(3-chloropyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole-4-yl}diethylamine, 2-[4-(3-chloropyridin-2-yl)phenyl]-6-morpholin-4-yl-1H-imidazo[4,5-b]pyridine, 2-[4-(3-chloropyridin-2-yl)phenyl]-6-pyrrolidin-l-yl-1H-imidazo[4,5-b]pyridine, 6-tert-butyl-2-[4-(3,5-dichloropyridin-2-yl)phenyl]- 1H-benzoiraidazole, 2-[4-(3,5-dichloropyridin-2-yl)phenyl]-4,6-bistrifluoromethyl-lH-benzoimidazole, 6-tert-butyl-2-[4-(3-chloro-5-trifluoromethylpyridin-2-yl } phenyl] -1H-benzoimidazole, 2-[4-(3-chloro-5-trifluoromethylpyridin-2-yl)phenyl]-4,6-bistrifluoromethyl-lH-benzoimidazole, 2-[4-(3-chloro-5-trifluoromethylpyridin-2-yl)phenyl]-5,7-bistrifluoromethyl-lH-benzoimidazole, N- [4'- (4,6-bistrifluoromethyl-lH-benzoimidazole-2-yl)-3-fluorobiphenyl-4-yl]methanesulfonamide, 6-tert-butyl-2- [4- (3-trifluoromethylpyridin-2-yl)phenyl]-1H-benzoimidazole, 4-chloro-6-trifluoromethyl-2-[4-(3- trifluoromethylpyridin-2-yl)phenyl]-1H-benzoimidazole, 6-chloro-2- [4- (3-trifluoromethylpyridin-2-yl)phenyl] -IH-benzoimidazole, 4,6-bistrifluoromethyl-2-[4-(3-trifluoromethyl pyridin-2-yl)phenyl]-1H-benzoimidazole, 6-trifluoromethyl-2-[4-(3-trifluoromethylpyridin-2-yl)phenyl]-lH-imidazo[4,5-b]pyridine, 5, 6-dichloro-2-[4-(3-trifluoromethylpyridin-2-yl)phenyl]-1H-benzoimidazole, 4-bromo-6-(trifluoromethyl)-2-(4-(3-(trifluoromethyl) pyridin-2-yl)phenyl)-1H-benzoimidazole, 6-bromo-2-(4-(3-(trifluoromethyl)pyridin-2-yl)phenyl)-1H-benzoimidazole, 6-fluoro-2-(4-(3-(trifluoromethyl)pyridin-2-yl)phenyl)-1H-benzoimidazole, 6-bromo-2-(4-(3-(trifluoromethyl)pyridin-2-yl)phenyl-IH-imidazo[4,5-b]pyridine, 4,6-dibromo-2-[4-(3-trifluoromethylpyridin-2-yl)phenyl]-1H-benzoimidazole, 6-morpholin-4-yl-2-[4-(3-trifluoromethylpyridin-2-yl)phenyl]-IH-benzoimidazole, 6-thiomorpholin-4-yl-2-[4-(3-trifluoromethyIpyridin-2-yl)phenyl]-1H-benzoimidazole, diethyl-{2-[4-(3-trifluoromethylpyridin-2-yl)phenyl]-3H-benzoimidazo-5-yl}amine, 4-morpholin-4-yl-6-trifluoromethyl-2-[4-(3- trifluoromethylpyridin-2-yl)phenyl]-1H-benzoimidazole, 4-thiomorpholin-4-yl-6-trifluoromethyl-2-[4-(3-trifluoromethylpyridin-2-yl)phenyl]-1H-benzoimidazole, 4-pyrrolidin-l-yl-6-trifluoromethyl-2-[4-(3-trifluoromethylpyridin-2-yl)phenyl]-1H-benzoimidazole, 6-tert-butyl-2-(4-pyridin-2-ylphenyl)-1H-benzoimidazole, 6-(trifluoromethyl)-2-(4-(pyridin-2-yl)phenyl)-1H-benzoimidazole, 4-chloro-6-(trifluoromethyl)-2-(4-(pyridin-2-yl)phenyl)-1H-benzoimidazole, 5,6-dichloro-2-(4-(pyridin-2-yl)phenyl)-1H-benzoimidazole, 4,6-bis (trifluoromethyl)-2-(4-(pyridin-2-yl)phenyl)-1H-benzoimidazole, 6-fluoro-2-(4-(pyridin-2-yl)phenyl)-1H-benzoimidazole, 6-bromo-2-(4-(pyridin-2-yl)phenyl)-1H-imidazo [4,5-b]pyridine, 4,6-dibromo-2-(4-pyridin-2-ylphenyl)-1H-benzoimidazole, 2- [4-(6-chloro-5-methylpyridazin-3-yl)phenyl]-4,6-bistrifluoromethyl-lH-benzoimidazole, 2-[4-(6-chloro-5-methylpyridazin-3-yl)phenyl]-5,7-bistri fluoromethyl-1H-benzoimida zole, 4-bromo-6-(trifluoromethyl)-2-(4-(4- (trifluoromethyl)pyrimidin-2-yl)phenyl)-1H-benzoimidazole, 4,6-dibromo-2-[4-(4-trifluoromethylpyrimidin-2-yl)phenyl]-1H-benzoimidazole, 6-tert-butyl-2-(4-(pyrimidin-2-yl)phenyl)-1H-benzoimidazole, 2- (4-(6-(trifluoromethyl)-lH-benzoimidazole-2-yl)phenyl)pyridin-3-carbonitrile, 2- (4-(6-(tert-butyl-lH-benzoimidazole-2-yl)phenyl)pyridin-3-carbonitrile, 6'- (4,6-dibromo-lH-benzoimidazole-2-yl)-[2,3']bipyridyl-3-carbonitrile, 2- [4-(3-chloropyrazin-2-yl)phenyl]-6-trifluoromethyl-1H-benzoimidazole, 6-tert-butyl-2-[4-(3-chloropyrazin-2-yl)phenyl]-1H-benzoimidazole, 6-bromo-2-[4-(3-chloropyrazin-2-yl)phenyl]-1H-benzoimidazole, 5,6-dichloro-2-[4-(3-chloropyrazin-2-yl)phenyl]-1H-benzoimidazole, 6-bromo-2-[4-(3-chloropyrazin-2-yl)phenyl]-1H-imidazo[4,5-b]pyridine, 6-tert-butyl-2-[4-(3-chloropyridin-2-yl)-2-fluorophenyl]-1H-benzoimidazole, 4-chloro-2-[4-(3-chloropyridin-2-yl)-2-fluorophenyl]-6-trifluoromethyl-1H-benzoimidazole, 2-[4-(3-chloropyridin-2-yl)-2-fluorophenyl]-6- methoxy-1H-benzoimidazole, 6-tert-butyl-2-[4-(3,5-dichloropyridin-2-yl)-2-fluorophenyl]-IH-benzoimidazole, 4-chloro-2-[4-(3, 5-dichloropyridin-2-yl)-2-fluorophenyl]-6-trifluoromethyl-lH-benzoimidazole, 2- [4- (3,5-dichloropyridin-2-yl)-2-fluorophenyl]-4,6-bistrifluoromethyl-1H-benzoimidazole, 4-chloro-2-[4-(3-chloro-5-trifluoromethylpyridin-2-yl)-2-fluorophenyl]-6-trifluoromethyl-lH-benzoimidazole, 2- [4-(3-chloro-5-trifluoromethylpyridin-2-yl)-2-f luorophenyl] -6-trifluoromethyl-1H-imidazo [4, 5-b]pyridine, 2- [4- (3-chloro-5-trifluoromethylpyridin-2-yl) -2-fluorophenyl] -6-methoxy-lH-benzoimidazole, N- [3,3'-difluoro-4' -(6-methoxy-lH-benzoimidazole-2-yl)biphenyl-4-yl]methanesulfonamide, 2- [2-fluoro-4-(3-trifluoromethylpyridin-2-yl)phenyl]-6-trifluoromethyl-1H-benzoimidazole, 6-tert-butyl-2-[2-fluoro-4-(3-trifluoromethylpyridin-2-yl)phenyl]-IH-benzoimidazole, 6-chloro-2- [2-fluoro-4- (3-trifluoromethylpyridin-2-yl)phenyl]-1H-benzoimidazole, 5-chloro-2- [2-fluoro-4- (3-trifluoromethylpyridin-2-yl)phenyl]-1H-benzoimidazole, 4-chloro-2- [2-f luoro-4- (3-trifluoromethylpyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole, 7-chloro-2- [2-fluoro-4- (3-trifluoromethylpyridin-2- ylphenyl trifluoro methy]-1H-benzoimidarole, 2- (2-fluoro-4-pyridin-2-yl)phenyl-6-trifluoromethyl-1H-benzoimidazole, 6-tert-butyl-2-(2-fluoro-4-pyridin-2-yl)phenyl-lH-benzoimidazole, 6-chloro-2-(2-fluoro-4-pyridin-2-yl)phenyl-lH-benzoimidazole, 2-(2-fluoro-4-pyridin-2-yl)phenyl-4,6-bistrifluoro methyl-lH-benzoimidazole, 2- [2-chloro-4- (3-chloropyridin-2-yl) phenyl] -6-trif luoromethyl-lH-benzoimidazole, 4-chloro-2-[2-chloro-4-(3-chloropyridin-2-yl)phenyl] -6-trifluoromethyl-lH-benzoimidazole, 2-[2-chloro-4-(3-chloropyridin-2-yl)phenyl]-6-trifluoromethyl-lH-imidazo[4,5-b]pyridine, 2-[2-chloro-4-(3, 5-dichloropyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole, 4-chloro-2-[2-chloro-4-(3, 5-dichloropyridin-2-yl)phenyl] -6-trif luoromethyl-lH-benzoimidazole, 2-[2-chloro-4-(3,5-dichloropyridin-2-yl)phenyl]-4, 6-bistrifluoromethyl-lH-benzoimidazole, 2-[2-chloro-4-(3, 5-dichloropyridin-2-yl)phenyl]-6-trifluoromethyl-lH-imidazo[4,5-b]pyridine, 2-[2-chloro-4-(3-chloro-5-trifluoromethylpyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole, 4-chloro-2-[2-chloro-4-(3-chloro-5- trif luoromethylpyridin-2-yl) phenyl] -6-trif luoromethyl -1H-benzoimidazole, N-[4'-(6-tert-butyl-lH-benzoimidazole-2-yl)-3'-chloro-3-fluorobiphenyl-4-yl]methanesulfonamide, N-[3'-chloro-4'-(4-chloro-6-trifluoromethyl-lH-benzoimidazole-2-yl)-3-fluorobiphenyl-4-yl] methanesulfonamide, N-[4'-(4,6-bistrifluoromethyl-lH-benzoimidazole-2-yl)-3'-chloro-3-fluorobiphenyl-4-yl}methanesulfonanri.de, 2-[2-chloro-4-(3-trifluoromethylpyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole, 4-chloro-2-[2-chloro-4-(3-trifluoromethylpyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole, 2-[2-chloro-4-(3-trifluoromethylpyridin-2-yl)phenyl] -4,6-bistrifluoromethyl-lH-benzoimidazole, 6-tert-butyl-2-[2-chloro-4-(3-methylpyridin-2-yl)phenyl]-IH-benzoimidazole, 6-chloro-2-(2-chloro-4-pyridin-2-ylphenyl)-1H-benzoimidazole, 2-(2-chloro-4-pyridin-2-ylphenyl)-6-trifluoromethyl-1H-imidazo[4,5-b]pyridine, 2-(2-chloro-4-pyridin-2-ylphenyl)-6-methoxy-lH-benzoimidazole, 2-[4-(3-chloropyridin-2-yl)naphthalen-1-yl]-6-trifluoromethyl-lH-benzoimidazole, 6-tert-butyl-2- [4- (3-chloropyridin-2-yl) naphthalen-1- yl] -1H-benzoirniciazole, 2-[4-(3-chloropyridin-2-yl)naphthalen-1-yl]-4,6-bistrifluoromethyl-lH-benzoimidazole, 2- [4-(3-chloropyridin-2-yl)naphthalen-1-yl] -6-trifluoromethyl-lH-imidazo[4,5-b]pyridine, 6-tert-butyl-2-[4-(3,5-dichloropyridin-2-yl)naphthalen-1-yl]-1H-benzoimidazole, 2-[4-(3,5-dichloropyridin-2-yl)naphthalen-1-yl]-4,6-bistrifluoromethyl-lH-benzoimidazole, 6-tert-butyl-2- [4- (3-chloro-5-trifluoromethylpyridin-2-yl) naphthalen-1-yl] -1H-benzoimidazole, 2- [4- (S-chloro-5-trifluoromethylpyridin-2-yl) naphthalen-1-yl] -4, 6-bistrifluoromethyl-lH-benzoimidazole, N-{4-[4-(4,6-bistrifluoromethyl-lH-benzoimidazole-2-yl) naphthalen-1-yl] -2-fluorophenyl }methanesulfonamide, 6-trifluoromethyl-2-[4-(3-trifluoromethylpyridin-2-yl) naphthalen-1-yl] -1H-benzoimidazole, 6-tert-butyl-2-(4-pyridin-2-ylnaphthalen-l-yl)-1H-benzoimidazole , 2-(4-pyridin-2-ylnaphthalen-l-yl)-4,6-bistrifluoromethyl-lH-benzoimidazole, 6-tert-butyl-2-[3-chloro-4-(3-chloropyridin-2-yDphenyl]-1H-benzoimidazole, 2-[3-chloro-4-(3,5-dichloropyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole, 6-tert--butyl-2~ [3-chloro-4- (3, 5-dichloropyridin-2-yl) phenyl ]-lH-benzoimidazo.le, 2-[3-chloro-4-(3,5-dichloropyridin-2-yl)phenyl]-6-methoxy-lH-benzoimidazole, 2-[3-chloro-4-(3,5-dichloropyridin-2-yl)phenyl]-5-methoxy-lH-behzoimidazole, 2-[3-chiqro-4-(3-chloro-5-trifluoromethylpyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole, 6-tert-butyl-2-[3-chloro-4-(3-chloro-5-trif luoromethylpyridin-2-yl) phenyl] -1H-benzoimidazole, 2-[3-chloro-4-(3-chloro-5-trifluoromethylpyridin-2-yl)phenyl]-6-methoxy-lH-benzoimidazole, 2-[3-chloro-4-(3-chloro-5-trifluoromethylpyridin-2-yl)phenyl]-5-methoxy-lH-benzoimidazole, N-[2'-chloro-4' -(4-chloro-6-trifluoromethyl-lH-benzoimidazole-2-yl)-3-fluorobiphenyl-4-yl]methanesulfonamide, N-[4'-(4,6-bistrifluoromethyl-lH-benzoimidazole-2-yl)-2'-chloro-3-fluorobiphenyl-4-yl]methanesulfonamide, 2-(3-chloro-4-pyridin-2-ylphenyl)-6-trifluoromethyl-1H-benzoimidazole, 6-tert-butyl-2-(3-chloro-4-pyridin-2-ylphenyl)-1H-benzoimidazole, 6-chloro-2-(3-chloro-4-pyridin-2-ylphenyl)-1H-benzoimidazole, 4-chloro-2-(3-chloro-4-pyridin-2-ylphenyl)-6- trifluoromethyl-lH-benzoimidazole, 5,6-dichloro-2-(3-chloro-4-(pyridin-2-yl)phenyl)-1H-benzoimidazole , 6-bromo-2-(3-chloro-4-(pyridin-2-yl)phenyl)-1H-benzoimidazole , 2-[3-chloro-4-(3-trifluoromethylpyridin-2-yl)phenyl]-6-trifluoromethyl-IH-benzoimidazole, 6-tert-butyl-2- [3-chloro-4- (3-'trif luoromethylpyridin-2-yl) phenyl] -1H-benzoimidazole, 6-chloro-2-[3-chloro-4-(3-trifluoromethylpyridin-2-yl)phenyl]-IH-benzoimidazole, 2-[3-chloro-4-(3-trifluoromethylpyridin-2-yl)phenyl]-6-methoxy-lH-benzoimidazole, 2-[3-chloro-4-(3-methylpyridin-2-yl)phenyl]-6-trifluoromethyl-1H-benzoimidazole, 3-chloro-6'-(6-trifluoromethyl-lH-benzoimidazole-2-yl)-[2,3']bipyridine, 3-chloro-6'-(6-chloro-lH-benzoimidazole-2-yl)-[2,3']bipyridine, 3-chloro-6'-(4-chloro-6-trifluoromethyl-lH-benzoimidazole-2-yl)-[2,3']bipyridine, 6'-(4,6-bistrifluoromethyl-lH-benzoimidazole-2-yl)-3-chloro-[2, 3' ]bipyridine, 4-bromo-2-(5-(3-chloropyridin-2-yl)pyridin-2-yl)-6-(trifluoromethyl)-1H-benzoimidazole, 6-bromo-2-(5-(3-chloropyridin-2-yl)pyridin-2-yl)-1H- benzoimidazole, 6'-(6-tert-butyl-lH-benzoiraidazole-2-yl) -3-chloro-[2,3']bipyridine, 3-chloro-6' -(5, 6-dichloro-lH-benzoimidazole-2-yl)-[2,3']bipyridine, 3-chloro-6'-(4, 6-dibromo-lH-benzoimidazole-2-yl)-[2,3']bipyridine, 6'-(6-bromo-lH-imidazo[4,5-b]pyridine-2-yl)-3-chloro-[2,3']bipyridine, 3-chloro-6'-(6-morpholin-4-yl-lH-benzoimidazole-2-yl)-[2,3']bipyridine, 3-chloro-6'-(6-thiomorpholin-4-yl-lH-benzoimidazole-2-yl)-[2,3']bipyridine, 3-chloro-6'-(4-morpholin-4-yl-6-trifluoromethyl-lH-benzoimidazole-2-yl)-[2, 3' ]bipyridine, 3-chloro-6'-(4-thiomorpholin-4-yl-6-trifluoromethyl-lH-benzoimidazole-2-yl)-[2,3']bipyridine, 3-chloro-6'-(4-pyrrolidin-l-yl-6-trifluoromethyl-lH-benzoimidazole-2-yl)-[2, 3' ]bipyridine, 3,5-dichloro-6' -(6-trifluoromethyl-lH-benzoimidazole-2-yl)-[2,3']bipyridine, 6'-(6-tert-butyl-lH-benzoimidazole-2-yl)-3,5-dichloro-[2,3']bipyridine, 3, 5-dichloro-6' -(6-chloro-lH-benzoimidazole-2-yl)-[2,3']bipyridine, 3, 5-dichloro-6' -(4-chloro-6-trifluoromethyl-lH- benzoimi ddzuie-z-yi)-[2,3']' ipyridine, 6' - (4, 6-bistrifluorornethyl-lH-benzoimidazole-2-yl)-3,5-dichloro-[2,3']bipyridine, 6'-(4,6-bistrifluoromethyl-lH-benzoimidazole-2-yl)-3-chloro-5-trifluoromethyl-[2,3']bipyridine, 6'-(6-methoxy-lH-benzoimidazole-2-yl)-3-chloro-5-trifluoromethyl-[2,3']bipyridine, 3-trifluoromethyl-6' -(6-trifluoromethyl-lH-benzoimidazole-2-yl)-[2,3'] bipyridine, 6'- (6-tert-butyl-lH-benzoimidazole-2-yl)-3-trifluoromethyl-[2,3' ]bipyridine, 6'-(6-chloro-lH-benzoimidazole-2-yl)-3-trifluoromethyl-[2,3' ]bipyridine, 6'- (4-chloro-6-trifluoromethyl-lH-benzoimidazole-2-yl)-3-trifluoromethyl-[2, 3' ]bipyridine, 6'-(5-trifluoromethyl-7-chloro-lH-benzoimidazole-2-yl)-3-trifluoromethyl-[2,3']bipyridine, 6'-(4,6-bistrifluoromethyl-lH-benzoimidazole-2-yl)-3-trifluoromethyl-[2,3' ]bipyridine, 6' - (5, 6-dichloro-lH-benzoimidazole-2-yl) -3-trifluoromethyl- [2,3']bipyridine, 4-bromo-6-(trifluoromethyl)-2-(5-(3-(trifluoromethyl)pyridin-2-yl)pyridin-2-yl)-1H-benzoimidazole, 6-bromo-2-(5-(3-(trifluoromethyl)pyridin-2-yl)pyridin-2-yl)-1H-benzoimidazole, 6-fluoro--2-: benzol- trifluoromethyl) pyridin-2-yl)pyridin-2-yl)-1H-benzoimidazole, 6'-(6-bromo-lH-imidazo[4,5-b]pyridine-2-yl)-3-trifluoromethyl[2, 3']bipyridine, 6'-(4,6-dibromo-lH-benzoimidazole-2-yl)-3-trifluoromethyl-[2,3']bipyridine, 6'-(6-morpholin-4-yl-lH-benzoimidazo-2-yl)-3-trifluoromethyl-[2,3']bipyridine, 6'-(4-morpholin-4-yl-6-trifluoromethyl-lH-benzoimidazole-2-yl)-3-trifluoromethyl-[2,3']bipyridine, 6'-(6-chloro-lH-benzoimidazole-2-yl)-[2,3']bipyridine, 6'-(6-trifluoromethyl-lH-imidazo[4,5-b]pyridine-2-yl)-[2,3']bipyridine, 5,6-dichloro-2-(5-(pyridin-2-yl)pyridin-2-yl)-1H-benzoimidazole, 6-tert-butyl-2-(6-naphthalen-l-ylpyridin-3-yl)-1H-benzoimidazole, 2- (6-naphthalen-l-ylpyridin-3-yl)-4,6-bistrifluoromethyl-1H-benzoimidazole, 2- (6-naphthalen-l-ylpyridin-3-yl)-5,7-bistrifluoromethyl-lH-benzoimidazole, 6- (trifluoromethyl)-2-(6-(naphthalen-l-yl)pyridin-3-yl)-1H-benzoimidazole, 6-chloro-2-(6-(naphthalen-l-yl)pyridin-3-yl)-1H-benzoimidazole, 2- (4-pyrnolyl-ylphenyl] -6-trifluoromethyl-lH-benzoimidazole, 2-(4-pyrrol-l-ylphenyl)-3H-imidazo[4, 5-b]pyridine, 6-chloro-2-(4-pyrrol-l-ylphenyl]-1H-benzoimidazole, 6-tert-butyl-2-(4-pyrrol-l-ylphenyl]-1H-benzoimidazole, 6-fluoro-2-(4-pyrrol-l-ylphenyl] -1H-benzoimidazole, 2-biphenyl-4-yl-6-trifluoromethyl-lH-benzoimidazole, 2-biphenyl-4-yl-3H-irnidazo [4, 5-b] pyridine, 2-biphenyl-4-yl-6-chloro-lH-benzoimidazole, 2-biphenyl-4-yl-6-tert-butyl-lH-benzoimidazole, 2-biphenyl-4-yl-6-fluoro-1H-benzoimidazole, 2-biphenyl-4-yl-6-methoxy-lH-benzoimidazole, 2-(4-phenoxyphenyl-6-trifluoromethyl)-1H-benzoimidazole, 2-(4-phenoxyphenyl)-3H-imidazo[4, 5-b]pyridine, 6-chloro-2-(4-phenoxyphenyl)-1H-benzoimidazole, 6-tert-butyl-2-(4-phenoxyphenyl)-1H-benzoimidazole, 6-fluoro-2-(4-phenoxyphenyl)-1H-benzoimidazole, 6-methoxy-2-(4-phenoxyphenyl)-1H-benzoimidazole, 2-[3-(4-chloropyrazol-l-ylmethyl)phenyl]-6-trifluoromethyl-lH-benzoimidazole, 6-chloro-2-[3-(4-chloropyrazol-l-ylmethyl)phenyl]-1H-benzoimidazole, 6-tert-butyl-2-[3-(4-chloropyrazol-l-ylmethyl)phenyl]-1H-benzoimidazole, 2-[3-chlomethyl-ylmethyl)phenyl-6-fluoro-lH-benzoimidazole, phenyl-[4-(6-trifluoromethyl-lH-benzoimidazole-2-yl)phenyl]methanone, [4-(6-tert-butyl-lH-benzoimidazole-2-yl)phenyl]phenylmethanone, 2-[4-(3-chloropyridin-2-yl)phenyl]-6-trifluoromethyl-1H-benzoimidazole chloride, 6-tert-butyl-2-[4-(3-chloropyridin-2-yl)phenyl]-1H-benzoimidazole chloride, 6-tert-butyl-2-[4-(3-chloropyridin-2-yl)naphthalen-l-yl]-lH-benzoimidazole chloride, 6'-(4,6-bistrifluoromethyl-lH-benzoimidazole-2-yl)-3-chloro[2,3']bipyridine chloride, 3-trifluoromethyl-6'-(6-trifluoromethyl-lH-benzoimidazole-2-yl)-[2, 3' ]bipyridine chloride, 6-tert-butyl-2-[4-(3-chloropyridin-2-yl)phenyl]-1H-benzoimidazole sodium salt, 3-trifluoromethyl-6' -(6-trifluoromethyl-lH-benzoimidazole-2-yl)-[2,3' ]bipyridine sulfate, 3-trifluoromethyl-6' -(6-trifluoromethyl-lH-benzoimidazole-2-yl)-[2,3' ]bipyridine phosphate, 3-trifluoromethyl-6' -(6-trifluoromethyl-lH-benzoimidazole-2-yl)-[2,3']bipyridine methansulfonate, and 3-trifluoromethyl-6'-(6-trifluoromethyl-lH-benzoimidazole-2-yl)-[2,3']bipyridine benzenesulfonate. In accordance with another aspect of the present invention, a method for preparing the compounds of Chemical Formula 1 is provided. The method may be conducted to chemically synthesize the compounds in accordance with the following reaction scheme, but is not limited thereto. The reaction scheme guides the preparation of representative compounds of the present invention, but modifications may be made to reagents and starting materials well known in the art so as to employ other compounds. Having chiral centers, some of the compounds represented by Chemical Formula 1 may be in form of enantiomers. Therefore, it should be noted that all optical isomers, R or S type stereoisomers, racemates and enantiomers of the compounds of Chemical Formula 1 are included within the scope of the present invention. In addition, the present invention includes the use of racemates, one or more enantiomers, one or more diastereomers, or combinations thereof, and methods for separating or preparing the isomers. In accordance with a further aspect of the present invention, provided is a pharmaceutical composition comprising the compound of Chemical Formula 1 as an active ingredient in an effective amount in combination with a pharmaceutically acceptable carrier. The following reaction scheme 1 accounts for the synthesis of the compounds represented by Chemical Formula 1: (Formula 1 Removed) As shown in Reaction Scheme 1, benzoic acid derivatives (IX) useful in synthesizing the object compound benzoimidazole compound 1 can be prepared by reacting commercially available halogen compounds (II) with boronic acid (III) in the presence of a palladium catalyst and a base in a typical reaction condition with the aid of microwaves (Tapolcsanyi et. al., Tetrahedron, 2002, 58, 10137). If not commercially available, boronic acid can be obtained through the oxidation of methylboronic acid (V) (Sharma et. al., Bioorg. Med. Chem. Lett. 1998, 8, 3459-3464). Alternatively, methylboronic acid (V) is reacted with a halogen compound (II), followed by oxidation to afford the benzoic acid derivatives (IX). On the other hand, halobenzoic acid (VIII) may be reacted with commercially available boronic acid (VII), or a commercially available benzoic acid (X) may be used. Such synthetic or commercially available benzoic acid derivatives are condensed with diamine derivatives (IX) in the presence of 0-(7-azabenzotriazol-l-yl)-N,N,N' , N'-tetramethyleuronium hexafluorophosphate to synthesize the intermediates, that is, amide compounds, which are then subjected to cyclization into the object compound benzoimidazole 1. In this case, the preparation of the benzoimidazole 1 may be achieved in the presence of acetic acid, a hydrochloric acid solution (Roglic et. al., Pharmazie, 2001, 56, 803), POC13 (Ries, et. al., J. Med. Chem, 1993, 36, 4040), polyphosphoric acid (Ries, et. al., J. Med. Chem, 1993, 36, 4040), or pyridine (Abha et. al., Indian Journal of Chemistry, 2002, 41, 1978) in a heated condition or with the aid of microwave (Lu, et. al., Syn. Comm. 2002, 32, 3703) . As shown above, the compounds of Chemical Formula 1 may be in form of salts, particularly pharmaceutically acceptable salts. The pharmaceutically available salts suitable for use in the present invention are those typically used in the art, such as acid addition salts, and include those disclosed in the literature (J. Pharm. Sci., 1977, 66, 1) . Examples of pharmaceutically acceptable acid addition salts suitable for use in the present invention include salts of inorganic acids, such as hydrochloric acid, hydrobromic acid, phosphoric acid, orthophosphoric aicd, sulfuric acid, and so on, and salts of organic acids, such as methanesulfonic acid, benzensulfonic acid, toluenesulfonic acid, acetic acid, propionic acid, lactic acid, citric acid, fumaric acid, malic acid, succinic acid, salicylic acid, maleic acid, glycerophosphoric acid, acetylsalicylic acid, and so on. In addition, pharmaceutically acceptable metal salts may be prepared using bases. Alkali metal salts or alkaline earth metal salts, lor example, may be obtained by dissolving compounds in an excess of an alrali metal hydroxide or alkaline earth metal hydroxide solution, filtering off non-dissolved compound salts, and vaporizing and drying the filtrate. In this regard, sodium, potassium or calcium salts are pharmaceutically suitable metal salts. In addition, silver salts corresponding to the metal salts can be obtained by reacting alkaline metal or alkali earth metal with suitable silver salts (e.g., nitrate). Pharmaceutically unacceptable salts and/or solvates of compounds of Chemical Formula 1 may be useful as intermediates for the preparation of pharmaceutically acceptable salts and/or solvates of compounds of Chemical Formula 1, or for the preparation of the compounds themselves of Chemical Formula 1, which also constitutes another aspect of the present invention. Compounds of Chemical Formula 1 may be prepared in crystalline or non-crystalline forms. If crystalline, the compounds may be arbitrarily hydrated or solvated. Compounds with arbitrary numbers of water molecyules as well as stoichiomatric hydrates fall into the scope of the present invention. Suitable are solvates which are pharmaceutically acceptable, like hydrates. Solvates suitable for use in the present invention comprise both stoichiometric and non-stoichiometric solvates. It is believed that, because they possess antagonistic activity against the vanilloid receptor, compounds of Chemical Formula 1 and pharmaceutically acceptable salts thereof have potential to be used for the prevention and treatment of indications and the treatment of the pain relevant thereto. The indications may be exemplified by pain, acute pain, chronic pain, neuropathic pain, postoperative pain, migraine, arthralgia, neuropathy, nerve injury, diabetic neuropathy, neurological illness, neurodermatitis, stroke, bladder hypersensitivity, irritable bowel syndrome, respiratory disorders such as asthma, chronic obstructive pulmonary disease, etc., burning, psoriasis, itching, vomiting, irritation of the skin, eyes, and mucous membranes, gastric-duodenal ulcers, inflammatory intestinal diseases, and inflammatory diseases. Thus, the present invention also provides the compounds of Chemical Formula 1, or pharmaceutically acceptable salts or solvates thereof, which are useful as active ingredients for the prevention and treatment of indications. Particularly, the present invention provides the compounds of Chemical Formula 1, or pharmaceutically acceptable salts or solvates thereof, which are useful for the prevention and treatment of pain. Further, the present invention provides a method for preventing or treating symptoms for which antagonism to the vanilloid receptor is helpful in the therapy thereof, comprising the administration of compounds of Chemical Formula 1, or pharmaceutical acceptable salts or solvates thereof in a therapeutically effective amount to mammalians having the symptoms. The present invention also provides uses of compounds of Chemical Formula 1, or pharmaceutically acceptable salts or solvates in the prevention and treatment of indications for the therapy of which antagonism to the vanilloid receptor is helpful. For use in therapy, compounds are generally formulated according to standard pharmaceutical practice. Thus, the present invention provides a pharmaceutical composition comprising a compound of Chemical formula 1 or a pharmaceutically acceptable salt or solvate thereof, in combination with an additive such as a pharmaceutically acceptable carrier, adjuvant, or diluent. For example, the compounds of Chemical Formula 1 may be dissolved in oils, propyleneglycol, or other solvents, which are usually used for the preparation of injections. Illustrative, but non-limitative examples of the carrier include physiological saline, polyethylene glycol, ethanol, vegetable oil, and isopropylmyristate. For topical use, the compounds of the present invention may be formulated into ointments or creams. Below, a description will be given of formulation methods and carriers, but not intened to limit the present invention. Pharmaceutical dosage forms of the compounds of the present invention include pharmaceutically acceptable salts or solvates of the compounds of the present invention alone or in combination with other pharmaceutically active compounds suitably bound or assembled thereto. The compounds of the present invention may be dissolved, suspended or emulsified in an aqueous solvent such as physiological saline, 5% dextrose, etc., or a non-aqueous solvent, such as synthetic fatty acid glyceride, higher fatty acid esters, propylene glycol, etc. The formulation of the present invention may comprise conventional additives such as dissolving agents, isotonic agents, suspensions, emulsifying agents, and preservatives. Depending on a patient's state and weight, severity of disease, dosage form, and administration route and period, the administration dose of the compounds of the present invention may be suitably selected by those skilled in the art. For effective therapy, the compounds of the present invention are administered in a dose from 0.0001 to 100 mg/ weight kg a day and preferably in a dose from 0.001 to 100 mg/weight kg a day. Administration may be conducted once or many times in a partitioned manner in a day. According administration method, the pharmaceutical composition may comprise the compound of the present invention in an amount from 0.001 to 99 weight%, and preferably in an amount from 0.01 to 60 weight%. The pharmaceutical composition of the present invention may be administered via various routes to mammalians such as mice, rats, livestock, humans, etc. All administration types may be expected, including, for example, oral or rectal administration, intravenous, intramuscular, subcutaneous, intraendometrial or intracerbroventricular injection. A better understanding of the present invention may be obtained through the following examples which are set forth to illustrate, but are not to be construed as the limit of the present invention. EXAMPLE 1: Preparation of 2- [4- (3-Chloropyridin-2-yl) -phenyl] -6-trifluoromethyl-lH-benzoimidazole Formula Removed (1) Preparation of 4- (3-chloropyridin-2-yl) benzoic acid To a solution of 5.3g (36.1mmol) 2, 3-dichloropyridine in 200 mL 1,2-dimethoxyethane and 200mL distilled water were added 22. 3g (0.21mol) Na2C03, 5.0g(30. 1mmol) 4- carboxylphenylboronic acid, and 0.5g Pd(PPh3)4, followed by mixing for 13 hours under a heat flux condition by stirring. After being cooled to room temperature, the solution was 50% concentrated in a vacuum. The aqueous layer was washed with ethyl acetate and adjusted into pH 1 with conc. HC1. Thereafter, extraction with ethyl acetate was conducted three times and the organic layer was dried over magnesium sulfate and concentrated in a vacuum. The concentrate was separated using column chromatography (developing solvent: chloroform/methanol=10/l) to afford 5.3 g of 4-(3-chloropyridin-2-yl)benzole acid as a white precipitate (yield: 75%). :H NMR (CD3OD) 6 : 8.57 (dd, 1H, J-4.8, 1.4Hz), 8.13 (dd, 2H, J=6.-9, 1.7Hz), 8.03 (dd, 1H, J=8.1, 1.4Hz), 7.75 (dd, 2H, J=6.9, 1.7Hz), 7.44 (dd, 1H, ,J=8.1, 4.8Hz) (2) Preparation of 4-(3-chloropyridin-2-yl)benzole acid To a solution of 0.5g (2.45mmol) 3-chloro-2-p-tolyl-pyridine in 5mL pyridine was added 2.5 mL distilled water, and then 1.36g (8.59mmol) potassium permanganate, followed by carefully stirring the solution to prevent potassium permanganate from contacting the container of the solution. Using a microwave reactor (Initiator Sixty, Biotage), the solution was allowed to react at 100°C for 5 min. The reaction solution was filtered to remove solids using celite. After the vacuum concentration of the filtrate, lOmL distilled water and lOmL ethyl acetate were added to the concentrate. The addition of a l.ON hydrochloric acid solution increased the pH of the aqueous solution to 4.0 before stirring for 40 min. The separated ethyl acetate was dried over anhydrous magnesium, sulfate and concentrated in a vacuum. A solution of the concentrate in methanol was separated using column chromatography (chloroform/methanol=10:l) to produce 0.35 g of 4-(3-chloropyridin-2-yl)benzoic acid (yield 61%). (3) Preparation of 2-[4-(3-chloropyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole 0.44g (2.5mmol) 4-trifluoromethylbenzene-l,2-diamine, 1.0 mL (5.0mmol) diisopropylethylamine and l.lg (6mmol) 0- (7-azabenzotriazol-yl)-N, N, N', N' -tetramethyleuronium hexafluorophosphate were added to a solution of 0.59g (2.Smmol) 4-(3-chloropyridin-2-yl)benzoic acid in 25 mL dime thylformamide, which was then stirred at room temperature for 16 hours and vacuum concentrated. The concentrate thus obtained was dissolved in ethyl acetate, washed with saturated NaHCO3 and saturated NaCl, dried over .magnesium sulfate, and concentrated in a vacuum. The residue was dissolved in acetic acid /toluene (15mL/1.5mL) and stirred at 75°C for 3 hours, followed by vacuum concentration. Again, the concentrate was dissolved in ethyl acetate, washed with saturated NaHC03 and saturated NaCl, dried over magnesium sulfate, and vacuum concentrated. The residue was separated using column chromatography (developing solvent: chloroform/methanol=30/l) to produce 0.77 g of 2-[4-(3-chloropyridin-2-yl) phenyl] -6-trifluoromethyl-lH-benzoimidazole (yield 82%). XH NMR (CDC13) 6 : 8.65 (m, 1H), 8.06 (d, 2H, J=8.4Hz), 7.93 (s, 1H), 7.85 (d,. 1H, J=8.2Hz), 7.77 (d, 2H, J=8.4HZ), 7.69 (d, 1H, J=8.2Hz), 7.52 . (d, 1H, J=8.2Hz), 7.34-7.30 (m, 1H) (4) Preparation of 2-[4-(3-chloropyridin-2- yl) phenyl] -6-trif luoromethyl-lH-benzoimidazole To a solution of 0.58g (2.5mmol) 4-(3-chloropyridin-2-yl)benzoic acid in 30mL anhydrous pyridine was added 0.44g (2.5mmol) 4-trifluoromethylbenzene-l, 2-diamine, followed by stirring for 6 hours in a heat flux condition. After cooling to room temperature, cold water (lOOmL) containing HC1 (lOmL) was added to the solution, which was then allowed to stand for 30 min to form precipitates. These were separated using column chromatography (developing solvent: chloroform/methanol= 30/1) to produce 0.70 g of 2-[4-(3-chloropyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole (yield 75%) . (5) Preparation of 2-[4-(3-chloropyridin-2- yl) phenyl] -6-trif luoromethyl-lH-benzoimidazole To a solution of 0.64g (2.75 mmol) 4-(3-chloropyridin-2-yl)benzoic acid in 25 mL 4N HC1 was added 0.44g (2. mmol) 4 -trifluoromethylbenzene-1,2-diamine, followed by sirring at 1800C for 6 hours. The solution was cooled to room temperature before the addition of 10% NaHCO3 (lOmL) and then extraction with ethyl acetate. The organic layer was dried over magnesium sulfate and vacuum concentrated. The residue thus obtained was separated using column chromatography (developing solvent: chloroform/methanol=30/l) to produce 0.61 g of 2-[4-(3-chloropyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole (yield 65%). (6) Preparation of 2-[4-(3-chloropyridin-2- yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole To a solution of 0.64g (2.75mmol) 4-(3-chloropyridin-2-yl)benzoic acid in 20mL POC13 was added 0.44g (2.5mmol) 4-trifluoromethylbenzene-l,2-diamine, followed by stirring for 3 hours in a heat flux condition. The solution was cooled to room temperature and dissolved in distilled water. After the adjustment of pH to 8-10 with ammonia, extraction was conducted using ethyl acetate. The organic layer was dried over magnesium sulfate and vacuum concentrated. The residue thus obtained was separated using column chromatography (developing solvent: chloroform/methanol=30/l) to produce 0.61 g of 2-[4-(3-chloropyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole (yield 65%). (7) Preparation of 2-[4-(3-chloropyridin-2- yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole To a solution of 0.70g (3.0mmol) 4-(3-chloropyridin-2-yl) benzole acid in 25 g polyphosphoric acid was added 0.44g (2.5mmol) 4-trifluoromethylbenzen-l, 2-diamine, followed by stirring at 150°C for 20 hours. Then, the solution was cooled to room temperature, dissolved in distilled water and adjusted to pH 9 to form precipitates. These precipitates were purified using column chromatography(developing solvent: chloroform/methanol=30/l) to afford 0.61 g of 2-[4-(3-chloropyridin-2-yl)phenyl] -6-trifluoromethyl-lH-benzoimidazole (yield 65%). (8) Preparation of 2-[4-(3-chloropyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole A solution of O.VOg (3.0mmol) 4-(3-chloropyridin-2- yl) benzole acid and 0.44g (2.5mmol) 4- trifluoromethylbenzene-1,2-diamine in 10 mL polyphosphoric acid was stirred for 5 min and irradiated for 15 min with microwaves in a microwave reactor (Initiator Sixty, Biotage). After cooling to room temperarture, 20mL distilled water was added to the solution which was then adjusted to a neutral pH value with NaOH. The precipitates thus obtained was filtered and separarted using column chromatography (developing solvent: chloroform/methanol=30/l) to produce 0.72 g of 2-[4-(3-chloropyridin-2-yl)phenyl]-6-trifluoromethyl-lH- benzoirn i : (9) Preparation of 2-[4-(3-chloropyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole 0.44g (2.5mmol) 4-trifluoromethylbenzene-l,2-diamine, 1.0mL(5.0mmol) diisopropylethylamine and l.lg (6mmol) 0-(7- azabenzotriazol-1-yl)-N,N,N', N'-tetramethyleuronium hexafluorophosphate were added to a solution of 0.59g (2.5mmol) 4-(3-chloropyridin-2-yl)benzole acid in 25mL dimethylformamide, which was then stirred for 5 min, irradiated for 15 min with microwaves in a microwave reactor (Initiator Sixty, Biotage) and concentrated in a vacuum. The concentrate was dissolved in ethyl acetate, washed with saturated NaHC03 and saturated NaCl, and dried over magnesium sulfate, followed by vacuum concentration. The residue thus obtained was dissolved in acetic acid (15mL) and stirred for 5 min before irradiation for 15 min with microwaves in a microwave reactor (Initiator Sixty, Biotage). Again, the reaction solution was cooled to room temperature, vacuum concentrated, dissolved in ethyl acetate, washed with saturated NaHCO3 and saturated NaCl, and dried over magnesium sulfate, followed by vacuum concentration. The residue was separated using column chromatography (developing solvent: chloroform/methanol=30/l) to produce 0.81 g of 2-[4-(3-chloropyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole (yield 90%). EXAMPLES 2 TO 16 The same procedure as in (3) of Example 1 was performed to produce Compounds 2 to 16. (Table Removed) EXAMPLE 17: Preparation of 2-[4-(3-chloropyridin-2-yl)phenyl]-6-morpholin-4-yl-lH-benzoimidazole (Figure Removed) To a solution of 162mg (0.42mmol) 6-bromo-2-(4-(3-chloropyridin-2-yl)phenyl)-1H-benzoimidazole in 6 mL dichlororaethane were added 0.2mL (1.15 mraol) N,N- dimethylisopropylethylamine and 0.1mL(0.57mmol) 2-(trimethylsilyl)ethoxyrnethyl chloride, followed by stirring at room temperature for 16 hours. After vacuum concentration, 26µL (0.30mmol) morpholine, 56.3mg (O.Ol3mmol) tris(dibenzylidine acetone)dipalladiura(0), lO mg (0.038 rnmol) 2-(di-t-butylphosphino)biphenyl, and 38.8mg (0.41mmol) sodiiim-t-botoxide were added to the concentrate, which was then* dissolved in 2.5mL toluene and allowed to react at 90°C for 10 min in a microwave reactor. After being cooled to room temperature, the product was dissolved in 5mL ethyl acetate and filtered with diatomite. The filtrate was dried over magnesium sulfate and vacuum concentrated. The concentrate was dissolved in 3 mL of a mixture of trifluoro fluoroacetic acid and methylene chloride (1:1) and stirred for 12 hours. Neutralization with 10% NaOH, extraction with ethyl acetate, drying with magnesium sulfate and vacuum concentration were sequentially conducted in that order. The residue thus obtained was separated using column chromatography (developing solvent: hexane/ethyl acetate=l/l) to produce 115mg of 2-[4-(3-chloropyridin-2-yl)phenyl]-6-morpholin-4-yl-lH-benzoimidazole (yield 70%). XH NMR (CD3OD) 8 : 8.64 (d, 1H), 8.18 (d, 2H), 8.10 (d, 1H), 7.87 (d, 2H), 7.66 (d, 1H), 7.61-7.45 (m, 2H), 7.21(dd, 1H), 3.91-3.87(m, 4H), 3.32-3.27(m, 4H) EXAMPLES 18 TO 24 The same procedure as in Example 17 was performed to produce Compounds 18 to 24 . (Table Removed) EXAMPLE 25: Preparation of 6-tert-butyl-2-[4-(3,5-dichloropyridin-2-yl) phenyl]-1H-benzoimidazole (Figure Removed) (1) Preparation of 4- (3, 5-dichloropyridin-2-yl) benzole acid The same procedure as in (1) of Example 1 was performed to produce 4- (3, 5-dichloropyridin-2-yl) benzoic acid (yield 79%) . 1H NMR (CD3OD) 6 : 8.74 (s, 1H) , 8.27-8.24 (m, 3H) , 7.92 (d, 2H) (2) Creparation of 6- tert-butyl-2- [4- ( 3, 5-dichloropyridin-2-yl)phenyl]-1H-benzoimidazole The same procedure as in (3) of Example 1 was performed to produce 6-tert-butyl-2-[4-(3,5-dichloropyridin-2-yl)phenyl]-1H-benzoimidazole (yield 90%). 1H NMR (CD3OD) 6 : 8.62 (s, 1H) , 8.20 (d, 2H) , 8.15 (s, 1H), 7.88 (d, 2H), 7.64 (s, 1H), 7.56 (s, 1H), 7.41 (d, 1H), 1.42 (s, 9H) EXAMPLE 26: Preparation of 2-[4-(3,5-dichloropyridin-2-yl)phenyl]-4,6-bistrifluoromethyl-lH-benzoimidazole ci The same procedure as in (2) of Example 25 was performed to produce 2- [4-(3,5-dichloropyridin-2-yl)phenyl]-4,6-bistrifluoromethyl-lH-benzoimidazole (yield 72%) . 1H NMR (CD3OD) 6 : 8.64 (d, 1H) , 8.34 (d, 1H) , 8.17-8.10 (m, 2H), 7.94 (d, 2H), 7.87-7.80 (m, 2H) EXAMPLE 27: Preparation of 6-tert-butyl-2-[4-(3-chloro-5-trifluoromethylpyridin-2-yl)phenyl]-IH-benzoimidazole ci (1) preparation of 1- 3-chloro-5- trifluoromethylpyridin-2-yl)benzole acid The same procedure as in (1) of Example 1 was performed to produce 4-(3-chloro-5-trifluoromethylpyridin-2-yl)benzoic acid (yield 75%). 1H NMR (CD3OD) 8 : 9.05 (d, 1H) , 8.51 (d, 1H) , 8.28 (dd, 2H), 7.97 (dd, 2H) (2) Preparation of 6-tert-butyl-2-[4-(3-chloro-5- trifluoromethylpyridin-2-yl)phenyl]-1H-benzoimidazole The same procedure as in (3) of Example 1 was performed to produce 6-tert-butyl-2-[4-(3-chloro-5-trifluoromethylpyridin-2-yl)phenyl]-1H-benzoimidazole (yield 87%) . XH NMR (CD3OD) 6 : 8.93 (s, 1H) , 8.38 (s, 1H) , 8.23 (d, 2H), 7.95 (d, 2H) , 7.69-7.50 (m, 2H) , 7.44-7.39 (m, 1H), 1.42 (s, 9H) EXAMPLE 28: Preparation of 2-[4-(3-chloro-5-trifluoromethylpyridin-2-yl)phenyl]-4,6-bistrifluoromethyl-1H-benzoimidazole and 2-[4-(3-chloro-5-trifluoromethylpyridin-2-yl)phenyl]-5,7-bistrifluoromethyl-1H-benzoimidazole (Figure Removed) The same procedure as in (2) of Example 27 was performed to produce 2-[4-(3-chloro-5-trifluoromethy].pyrid.in-2-yl) phenyl] -4,6-bistrif luoromethyl 1H-benzoimidazole and 2-[4-(3-chloro-5-trifluoromethylpyridin-2-yl)phenyl]-5,7-bistrifluoromethyl-1H-benzoimidazole (yield 68%). 1H NMR (CD3OD) 6: 8.95 (d, 0.7H), 8.92 (d, 0.3H), 8.40-8.35 (m, 2.OH), 8.18 (s, 0.7H), 8.16 (s, 0.3H), 8.01-7.99 (m, l.OH), 7.94-7.90 (m,'1H), 7.87 (d, 0.3H), 7.85 (d, 0.7H), 7.44 (s, 0.3H), 7.39 (d, 0.7H) EXAMPLE 29: Preparation of N-[4'-(4,6-bistrifluoromethyl-lH-benzoimidazole-2-yl)-3-fluorobiphenyl-4-yl]methanesulfonamide (Figure Removed) (1) Preparation of 4-(3-fluoro-4- methanesulfonylaminophenyl)benzole acid The same procedure as in (1) of Example 1 was performed to produce 4-(3-fluoro-4-methanesulfonylaminophenyl)benzole acid (yield 58%). 1H NMR (CD3OD) 6 : 8.22 (dd, 2H), 7.87 (dd, 2H), 7.77-7.64 (m, 3H), 3.18 (s, 3H) (2) Preparation of N-[4'-(4,6-bistrifluoromethyl-lH- benzoimidazole-2-yl)-3-fluorobiphenyl-4- yl]methanesulfonamide The same procedure as in (3) of Example 1 was performed to produce N-[4'-(4,6-bistrifluQro^§l;l-jlyl-lg-benzoimidazole-2-yl)-3-fluorobiphenyl-4-yl]methanesulfonamide (yield 62%). XH NMR (CD3OD) 6: 8.13 (d, 2H), 7.83 (d, 2H), 7.72 (s, 1H), 7.68-7.62 (m, 2H), 7.59-7.55 (m, 2H), 3.07 (s, 3H) EXAMPLE 30: Preparation of 6-tert-butyl-2-[4-(3-trifluoromethylpyridin-2-yl)phenyl]-lH-benzoimidazole (Figure Removed) (1) Preparation of 4-(3-trifluoromethylpyridin-2- yl)benzoic acid The same procedure as in (1) of Example 1 was performed to produce 4-(3-trifluoromethylpyridin-2-yl)benzoic acid (yield 84%) . 1H NMR (CD3OD) 6: 8.84 (d, 1H) , 8.30 (d, 1H) , 8.11 (d, 2H), 7.68-7.64 (m, 1H) , 7.56 (d, 2H) (2) Preparation of 6-tert-butyl-2-[4-(3- trif luoromethylpyridin-2-yl ) phenyl ] -IH-benzoimidazole The same procedure as in (3) of Example 1 was performed to produce 6-tert-butyl-2-[4-(3-trif luoromethylpyridin-2-yl) phenyl ] -IH-benzoimidazole (yield 93%) . 1H NMR (CDC13) 6 : 8.87 (d, 1H) , 8.13 (s, 1H) , 8.11 (d, 2H), 7.66 (s, 1H), 7.62 (d, 2H), 7.61 (s, 1H) , 7.50-7.47 (m, 1H), 7.36 (d, 1H) , 1.39 (s, 9H) EXAMPLES 31 TO 40 The same procedure as in (3) of Example 1 was performed to produce compounds 31 to 40. (Table Removed) EXAMPLE 41: Preparation of 6-morpholin-4-yl-2-[4-(3-trifluoromethylpyridin-2-yl)phenyl]-IH-benzoimidazole (Figure Removed) The same procedure as in Example 17 was performed to produce 6-morpholin-4-yl-2-[4-(3-trifluoromethylpyridin-2-yl)phenyl]-1H-benzoimidazole (yield 73%). 1H NMR (CD3OD) 8 : 8.85 (d, 1H) , 8.32 (dd, 1H) , 8.17 (d, 2H), 7.69-7.62 (m, 3H) , 7.58 (d, 1H) , 7.14 (d, 1H) , 7.09 (dd, 1H), 3.83 (dt, 4H) , 3.18 (dt, 4H) EXAMPLES 42 TO 46 (Table Removed) The same procedure as in produce Compounds 42 to 46. Example 41 was performed to EXAMPLE 47: Preparation of 6-tert-butyl-2-(4-pyridin-2-ylphenyl)-1H-benzoimidazole (Figure Removed) (1) Preparation of 4-(pyridin-2-yl)benzoic acid The same procedure as in (1) of Example 1 was performed to produce 4-(pyridin-2-yl)benzoic acid (yield 80%) . 1H NMR (CD3OD) 6 : 8.66 (d, 1H) , 8.14 (d, 2H) , 8.07 (d, 2H), 7.94 (d, 2H), 7.43-7.40 (m, 1H) (2) Preparation of 6-tert-butyl-2-(4-pyridin-2- ylphenyl)-1H-benzoimidazole The same procedure as in (3) of Example 1 was performed to produce 6-tert-butyl-2-(4-pyridin-2-ylphenyl)-IH-benzoimidazole (yield 84%). 1R NMR (CD3OD) 6 : 8.69 (d, 1H) , 8.22 (s, 4H), 7.98 (dd, 2H), 7.69 (d, 1H) , 7.64 (d, 1H) , 7.55 (dd, 1H) , 7.43 (dd, 1H), 1.41 (s, 9H) EXAMPLES 48 TO 54 The same procedure as in (2) of Example 47 was performed to produce Compounds 48 to 54. (Table Removed) EXAMPLE 55: Preparation of 2-[4-(6-chloro-5-methylpyridazin-3-yl)phenyl]-4,6-bistrifluoromethyl-lH-benzoimidazole]- 2- [ 4- (6-chloro-5-methylpyridazin-3-yl)phenyl]-5,7-bistrifluoromethyl-lH-benzoimidazole (Figure Removed) (1) Preparation of 4-(6-chloro-5-methylpyridazin-3- yl)benzole acid The same procedure as in (1) of Example 1 was performed to produce 4-(6-chloro-5-methylpyridazin-3-yl)benzole acid (yield 52%) . 1H NMR (CD3OD) 5 : 8.20 (s, 1H) , 8.20-8.16 (m, 4H) , 2.53 (s, 3H) (2) Preparation of 2-[4-(6-chloro-5-methylpyridazin- 3-yl)phenyl]-4,6-bistrifluoromethyl-lH-benzoimidazole and 2-[4-(6-chloro-5-methylpyridazin-3-yl)phenyl]-5,7- bistrifluoromethyl-lH-benzoimidazole The same procedure as in (3) of Example 1 was performed to produce 2- [4- (G-chloro-S-methylpyridazin-3-yl) phenyl] -4, 6-bistrif luoromethyl-lH-benzoimidazole and 2-[4- (6-chloro-5-methylpyridazin-3-yl)phenyl] -5,7-bistrifluoromethyl-lH-benzoimidazole (yield 71%) . XH NMR (CD3OD) 6: 8.89 (d, 0.5H), 8.64 (d, 0.5H), 8.45-8.37 (m, 2.5H), 8.33-8.15 (m, 2.5H), 7.70-7.60 (m, l.OH), 2.75 (s, 1.5H), 2.54 (s, 1.5H) EXAMPLE 56: Preparation of 4-bromo-6- (trif luoromethyl) -2- (4- (4- (triflumethyl)pyrimidin-2-yl) phenyl) -1H-benzoimidazole F,C 3 (1) Preparation of 4- (4-trifluoromethylpyrimidin-2- yl) benzole acid The same procedure as in (1) of Example 1 was performed to produce 4- (4-trifluoromethylpyrimidin-2-yl)benzoic acid (yield 77%). 1H NMR (CD3OD) 8: 9.20 (d, 1H) , 8.62 (dd, 2H) , 8.19 (dd, 2H), 7.81 (d, 1H) (2) Preparation of 4-bromo-6- (trifluoromethyl) -2- (4- (4- (trifluoromethyl )pyrimidin-2-yl) phenyl) -1H- benzoimidazole The same procedure as in (3) of Example 1 was performed to produce; 4-bLomo-6-(trifluoromethyl)-2-(4-(4-(trifluoromethyl)pyrimidin-2-yl}phenyl)-1H-benzoimidazole (yield 72%). 1H NMR (CDC13) 5 : 9.14 (d, 1H) , 8.74 (d, 2H) , 8.27 (d, 2H), 8.00 (s, 1H), 7.76 (s, 1H) , 7.62 (d, 1H) EXAMPLE 57: Preparation of 4,6-dibromo-2-[4-(4- trifluoromethylpyrimidin-2-yl)phenyl]-1H-benzoimidazole (Figure Removed) The same procedure as in (2) of Example 56 was performed to produce 4,6-dibromo-2-[4-(4-trifluoromethylpyrimidin-2-yl)phenyl]-1H-benzoimidazole (yield 64%). 1H NMR (CD3OD) 8 : 9.18 (d, 1H) , 8.70 (dd, 1H) , 8.56 (d, 2H), 8.36 (dd, 1H) , 8.26 (s, 1H) , 8.15 (d, 2H) EXAMPLE 58: Preparation of 6-tert-butyl-2-(4-(pyrimidin-2-yl)phenyl)-1H-benzoimidazole (Figure Removed) (1) Preparation of 4-(pyrimidin-2-yl)benzole acid The same procedure as in (1) of Example 1 was performed to produce 4-(pyrimidin-2-yl)benzole acid (yield 74%) . 1H NMR 8.88 (d, 2H) , 8.47 (d, 2H) , 8.12 (d, 2H), 7.39 (t, 1H) (2) Preparation of 6-tert-butyl-2-(4-(pyriraidin-2-yl)phenyl)-1H-benzoimidazole The same procedure as in (3) of Example 1 was performed to produce 6-tert-butyl-2-(4-(pyrimidin-2-yl)phenyl)-1H-benzoimidazole (yield 92%). 1R NMR (CD3OD) 8 : 8.88 (d, 2H) , 8.58 (dd, 2H) , 8.21 (dd, 2H) , 7.64 (d, 1H) , 7.56 (d, 1H) , 7.42-7.37 (m, 2H) , 1.41 (s, 9H) EXAMPLE 59: Preparation of 2-(4-(6-(trifluoromethyl)-1H-benzoimidazole-2-yl)phenyl) pyridin-3-carbonitrile (1) Preparation of 4-(3-cyanopyridin-2-yl)benzoic acid The same procedure as in (1) of Example 1 was performed to produce 4-(3-cyanopyridin-2-yl)benzoic acid (yield 59%). XH NMR (CD3OD) 5 : 9.04 (dd, 1H) , 8.46 (dd, 1H), 8.32 (d, 2H), 8.12 (d, 2H), 7.74 (dd, 1H) (2) Preparation of 2-(4-(6-(trifluoromethyl)-1H- benzoimidazole-2-yl)phenyl) pyridin-3-carbonitrile The same as in (3) of Example was performed to produce 2- (4-(6-(trifluoromethyl)-1H-benzoimidazole-2-yl)phenyl) pyridin-3-carbonitrile (yield 76%) . 1H NMR (CD3OD) 6 : 8.89 (dd, 1H) , 8.32-8.26 (m, 3H) , 8.08 (dd, 2H), 7.90 (s, 1H) , 7.75 (d, 1H) , 7.60-7.53 (m, 2H) EXAMPLES 60 AND 61 The same procedure as in (2) of Example 59 was performed to produce Compouds 60 and 61. (Table Removed) EXAMPLE 62: Preparation of 2-[4-(3-chloropyrazin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole (Figure Removed) (1) Preparation of 4-(3-chloropyrazin-2-yl)benzole acid The same procedure as in (1) of Example 1 was performed to produce 4-(3-chloropyrazin-2-yl)benzole acid (yield 79%). :H NMR (CD3OD) 6 : 8.72 (d, 1H) , 8.50 (d, 1H) , 8.20 (d, 2H), 7.93 (d, 2H) (2) Preparation of 2-[4-(3-chloropyrazin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole The same procedure as in (3) of Example 1 was performed to produce 2- [4- (3-chloropyrazin-2-yl)phenyl] -6-trifluoromethyl-lH-benzoimidazole (yield 96%). 1H NMR (CDC13) 6 : 8.62 (d, 1H) , 8.39 (d, 1H) , 8.20 (d, 2H), 7.99 (s, 1H), 7.97 (d, 2H) , 7.71 (s, 1H) , 7.52 (dd, 1H) EXAMPLES 63 AND 66 The same procedure as in (2) of Example 62 was performed to produce Compounds 63 to 66. (Table Removed) EXAMPLE 67: Preparation of 6-tert-butyl-2-[4-(3- chloropyridin-2-yl)-2-fluorophenyl]-1H-benzoimidazole Cl (Table Removed) (1) Preparation of 4-(3-chloropyridin-2-yl)-2- fluorobenzoic acid The same procedure as in (1) of Example 1 was performed to produce 4-(3-chloropyridin-2-yl)-2-fluorobenzoic acid (yield 11%) . XH NMR (CD3OD) 6 : 8.51 (d, 1H) , 7.99-7.93 (m, 2H) , 7.52-7.48 (m, 2H), 7.42-7.36 (m, 1H), 1.42 (s, 9H) (2) Preparation of 6-tert-butyl-2-[4-(3- chloropyridin-2-yl)-2-fluorophenyl]-1H-benzoimidazole The same procedure as in (3) of Example 1 was performed to produce 6-tert-butyl-2-[4-(3-chloropyridin-2-yl)-2-fluorophenyl]-IH-benzoimidazole (yield 91%). XH NMR (CD3OD) 6 : 8.62 (d, 1H), 8.05 (dd, 1H), 8.03 (d, 1H), 7.74-7.70 (m, 2H), 7.66 (s, 1H)., 7.47-7.43 (m, 2H) EXAMPLES 68 AND 69 The same procedure as in (2) of Example 27 was performed to produce Compounds 68 and 69. (Table Removed) EXAMPLE 70: Preparation of 6-tert-butyl-2-[4-(3,5-dichloropyridin-2-yl)-2-fluorophenyl]-1H-benzoimidazole (Figure Removed) (1) Preparation of 4-(3,5-dichloropyridin-2-yl)-2- fluorobenzoic acid The same procedure as in (1) of Example 1 was performed to produce 4-(3,5-dichloropyridin-2-yl)-2- fluorobenzoic acid (yield 69%). 1H NMR (CD3OD) 6 : 8.55 (s, 1H), 8.07 (s, 1H), 7.93 (dd, 1H), 7.59-7.52 (m, 2H) (2) Preparation of 6-tert-butyl-2-[4-(3,5- dichlpropyridin-2-yl)-2-fluorophenyl]-1H-benzoimidazole The same procedure as in (3) of Example 1 was performed to produce 6-tert-butyl-2-[4-(3,5-dichloropyridin-2-yl)-2-fluorophenyl]-1H-benzoimidazole (yield 88%). *H NMR (CD3OD) 6 : 8.64 (s, 1H), 8.27 (d, 1H), 8.16 (s, 1H), 77.72-7.68 (m, 3H), 7.60 (d, 1H), 7.45 (d, 1H), 1.42 (s, 9H) EXAMPLES 71 AND 72 The same procedure as in (2) of Example 70 was performed to produce Compounds 71 and 72. (Table Removed) EXAMPLE 73: Preparation of 4-chloro-2-[4-(3-chloro-5 trifluoromethylpyridin-2-yl)-2-fluorophenyl]-6-trifluoromethyl-lH-benzoimidazole (Figure Removed) (1) Preparation of 4-(3-chloro-5- trifluoromethylpyridin-2-yl)-2-fluorobenzoic acid The same procedure as in (1) of Example 1 was performed to produce 4-(3-chloro-5-trifluoromethylpyridin-2-yl)-2-fluorobenzoic acid (yield 72%). *H NMR (CD3OD) 6 : 8.85 (d, 1H), 8.31 (d, 1H), 7.98 (dd, 1H), 7.60-7.51 (m, 2H) (2) Preparation of 4-chloro-2-[4-(3-chloro-5- trifluoromethylpyridin-2-yl)-2-fluorophenyl]-6- trifluoromethyl-lH-benzoimidazole The same procedure as in (3) of Example 1 was performed to produce 4-chloro-2-[4-(3-chloro-5-trifiuoromethylpyridin-2-yl)-2-fluorophenyl]-6-trifluoromethyl-lH-benzoimidazole (yield 81%). XH NMR (CD3OD) 5 : 8.96 (s, 1H), 8.42 (s, 2H), 7.92 (s,- 1H), 7.88-7.82 (m, 2H), 7.62 (s, 1H) EXAMPLES 74 AND 75 The same procedure as in (2) of Example 73 was performed to produce Compounds 74 and 75. (Table Removed) EXAMPLE 76: Preparation of N-[3,3'-difluoro-4' -(6-methoxy-lH-benzoimidazole-2-yl)biphenyl-4-yl]methanesulfonamide (Table Removed) (1) Preparation of 4-(3-fluoro-4- methanesulfonylaminophenyl) -2-fluorobenzoic acid The same procedure as in (1) of Example 1 was performed to produce 4-(3-fluoro-4- methanesulfonylaminophenyl)-2-fluorobenzoic acid (yield 52%). 1H NMR (CD3OD) 8 : 7.94-7.91 (m, 1H) , 7.56-7.52 (m, 2H), 7.49-7.41 (m, 3H) , 2.98 (s, 3H) (2) Preparation of N- [3, 3' -difluoro-4' - (6-methoxy-lH-benzoimidazole-2-yl)biphenyl-4-yl]methanesulfonamide The same procedure as in (3) of Example 1 was performed to produce N- [3, 3' -difluoro-4' - (6-methoxy-lH-benzoimidazole-2-yl)biphenyl-4-yl]methanesulfonamide (yield 55%) . XH NMR (CD3OD) 6 : 7.73 (d, 1H) , 7.71 (d, 1H) , 7.58 (s, 1H), 7.55-7.52 (m, 3H) , 7.50-7.48 (m, 1H) , 7.28-7.25 (m, 1H) , 6.85 (d, 1H) , 3.86 (s, 3H) , 2.99 (s, 3H) EXAMPLE 77 Preparation of 2- [2-fluoro-4- (3-trif luoromethylpyridin-2-yl ) phenyl] -6-trifluoromethyl-lH-benzoimidazole (1) Preparation of 2-fluoro-4- (3- trif luoromethylpyridin-2-yl ) benzoic acid The same procedure as in (1) of Example 1 was performed to produce 2-fluoro-4- (3-trifluoromethylpyridin-2-yl)benzoic acid (yield 71%). 1H NMR (CD3OD) 8 : 8.85 (d, 1H) , 8.30 (d, 1H) , 8.00 (dd, 1H), 7.68 (dd, 1H), 7.38-7.31 (m, 2H) (2) Preparation of 2- [2-fluoro-4-(3- trif luoromethylpyridin-2-yl) phenyl] -6-trifluoromethyl-lH- benzoimidazole The same procedure as in (3) of Example 1 was performed to produce 2-[2-fluoro-4-(3- trifluoromethylpyridin-2-yl)phenyl] -6-trifluoromethyl-lH-benzoimidazole (yield 83%). 1H NMR (CD3OD) 5 : 8.89 (d, 1H) , 8.36-8.32 (m, 2H) , 8.00 (s, 1H), 7.83 (d, 1H), 7.72-7.68 (m, 1H) , 7.60 (d, 1H), 7.55 (s, 1H), 7.52 (d, 1H) EXAMPLES 78 AND 80 The same procedure as in (2) of Example 77 was performed to produce Compounds 78 to 80. (Table Removed) 7.90 (m, l.OH) , 7.68-7.41 (m, 3.4H), 7.33-7.26 (m, 1.0H) EXAMPLE 81: Preparation of 2-(2-fluoro-4-pyridin-2 yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole (1) Preparation of 2-fluoro-4-pyridin-2-ylbenzoic acid The same procedure as in (1) of Example 1 was performed to produce 2-fluoro-4-pyridin-2-ylbenzoic acid (yield 69%). XH NMR (CD3OD) 6 : 7.79-7.74 (m, 2H) , 7.46-7.34 (m, 3H), 7.11-7.02 (m, 2H) (2) Preparation of 2-(2-fluoro-4-pyridin-2- yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole The same procedure as in (3) of Example 1 was performed to produce 2-(2-fluoro-4-pyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole (yield 82%). 1H NMR (CDC13) 8 : 8.77-8.71 (m, 1H) , 8.06-7.90 (m, 3H) , 7.89-7.83 (m, 2H), 7.62-7.51 (m, 4H) EXAMPLES 82 AND 84 The same procedure as in (2) of Example 81 was (Table Removed) EXAMPLE 85: Preparation of 2-[2-chloro-4-(3-chloropyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole (Table Removed) (1) Preparation of 2-chloro-4-(3-chloropyridin-2-yl)benzoic acid The same procedure as in (1) of Example 1 was performed to produce 2-chloro-4-(3-chloropyridin-2-yl)benzole acid (yield 80%). XH NMR (CD3OD) 8 : 8.60-8.58 (m, 1H) , 8.02 (dd, 1H) , 7.95 (d, 1H), 7.79 (d, 1H) , 7.69 (dd, 1H) , 7.48-7.44 (m, 1H) (2) Preparation of 2- [2-chloro-4- (3-chloropyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole The same procedure as in (3) of Example 1 was performed to produce 2-[2-chloro-4-(3-chloropyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole (yield 91%). XH NMR (CD3OD) 8 : 8.63 (d, 1H) , 8.05-7.98 (m, 3H) , 7.95 (s, IE), 7.85 (d, 1H) , 7.82 (s, 1H) , 7.60 (d, 1H) , 7.48-7.44 (m, 1H) EXAMPLES 86 AND 87 The same procedure as in (2) of Example 85 was performed to produce Compounds 86 and 87. (Table Removed) EXAMPLE 88: Preparation of 2-[2-chloro-4-(3,5-dichloropyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole (Figure Removed) (1) Preparation of 2-chloro-4-(3,5-dichloropyridin-2- yl)benzole acid The same procedure as in (1) of Example 1 was performed to produce 2-chloro-4-(3,5-dichloropyridin-2-yl)benzoic acid (yield 72%). 1H NMR (CD3OD) 5 : 8.62 (d, 1H) , 8.15 (d, 1H) , 7.93 (d, 1H) , 7.82 (d, 1H), 7.72 (dd, 1H) (2) Preparation of 2-[2-chloro-4- (3,5- dichloropyridin-2-yl)phenyl]-6-trifluoromethyl-lH- benzoimidazole The same procedure as in (3) of Example 1 was performed to produce 2-[2-chloro-4-(3,5-dichloropyridin-2-yl) phenyl] -(6-trifluoromethyl-lH-benzoimidazole (yield 88%) . 1H NMR (CD3OD) 8 : 8.63 (d, 1H) , 8.16 (d, 1H) , 8.03-7.95 (m, 3H), 7.87-7.82 (m, 2H) , 7.59 (d, 1H) EXAMPLES 89 AND 91 The same procedure as in (2) of Example 88 was performed to produce Compounds 89 to 91. (Table Removed) EXAMPLE 92: Preparation of 2-[2-chloro-4-(3-chloro-5-trifluoromethylpyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole (Table Removed) (1) Preparation of 2-chloro-4-(3-chloro-5- trifluoromethylpyridin-2-yl)benzoic acid The same procedure as in (1) of Example 1 was performed to produce 2-chloro-4-(3-chloro-5-trifluoromethylpyridin-2-yl)benzoic acid (yield 68%). :H NMR (CD3OD) 8: 8.92 (d, IH) , 8.38 (d, IH) , 7.96 (d, IH), 7.87 (d, IH), 7.77 (dd, IH) (2) Preparation of 2-[2-chloro-4-(3-chloro-5- trifluoromethylpyridin-2-yl)phenyl]-6-trifluoromethyl-lH- benzoimidazole The same procedure as in (3) of Example 1 was performed to produce 2-[2-chloro-4-(3-chloro-5- trifluororn.ethylpyridpin-2-yl) phenyl]-6-trifluoromethyl-lH-benzoimidazole (yield 88%). 1H NMR (CDC13) 8.85 (s, 1H), 8.37 (d, 1H), 8.08 (s, 1H), 8.01 (s, 1H), 7.94 (s, 1H), 7.88 (d, 1H), 7.78 (d, 1H), 7.56 (d, 1H) EXAMPLE 93: .Preparation of 4-chloro-2-[2-chloro-4-(3-chloro-5-trifluoromethylpyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole The same procedure as in (2) of Example 92 was performed to produce 4-chloro-2-[2-chloro-4-(3-chloro-5-trifluoromethylpyridin-2-yl)phenyl]-6-trifluoromethyl-1H-benzoimidazole (yield 71%). 1H NMR (CDC13) 6 : 8.89 (s, 1H), 8.72 (d, 1«), 8.10 (s, 1H), 7.94-7.87 (m, 3H), 7.64 (s, 1H) EXAMPLE 94: Preparation of N-[4' -(6-tert-butyl-lH-benzoimidazole-2-yl)-3' -chloro-3-fluorobiphenyl-4-yl] methanesulfonamide (Figure Removed) (1) Preparation of 4-(3-fluoro-4- methanesulfonylaminophenyl)-2-chlorobenzoic acid The same procedure as in (1) of Example 1 was performed to produce 4-(3-fluoro-4- methanesulfonylaminophenyl)-2-chlorobenzoic acid (yield 54%) . 1H NMR (CD3OD) 6 : 7.93 (d, 1H) , 7.78 (d, 1H) , 7.67-7.63 (m, 2H), 7.60-7.53 (m, 2H), 3.05 (s, 3H) (2) Preparation of N- [4' -(6-tert-butyl-lH- benzoimidazole-2-yl)-3' -chloro-3-fluorobiphenyl-4- yl]methanesulfonamide The same procedure as in (3) of Example 1 was performed to produce N-[4'-(6-tert-butyl-lH-benzoimidazole-2-yl)-3'-chloro-3-fluorobiphenyl-4-yl]methanesulfonamide (yield 60%). lti NMR (CD3OD) 5 : 7.94 (d, 1H) , 7.89 (s, 1H) , 7.75 (d, 1H), 7.67-7.56 (m, 5H) , 7.44 (d, 1H), 3.06 (s, 3H) , 1.41 (s, 9H) EXAMPLES 95 AND 96 The same procedure as in (2) of Example 94 was performed to produce Compounds 95 and 96. (Table Removed) EXAMPLE 97: Preparation of 2-[2-chloro-4-(3-trifluoromethylpyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole (Figure Removed) (1) Preparation of 2-chloro-4-(3- trifluoromethylpyridin-2-yl)benzole acid The same procedure as in (1) of Example 1 was performed to produce 2-chloro-4-(3-trifluoromethylpyridin-2-yl)benzoic acid (yield 73%) . 1H NMR (CD3OD) 6 : 8.78-8.76 (m, 1H) , 8.20 (d, 1H) , 7.91 (d, 1H), 7.80-7.76 (m, 2H), 7.41-7.39 (m, 1H) (2) Preparation of 2-[2-chloro-4-(3- trifluoromethylpyridin-2-yl)phenyl]-6-trifluoromethyl-lH- benzoimidazole The same procedure as in (3) of Example 1 was performed to produce 2-[2-chloro-4-(3- trifluoromethylpyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole (yield 92%) . 1H NMR (CDC13) 6 : 8.89 (d, 1H), 8.59 (d, 1H), 8.15 (d, 1H), 8.10-7.75 (m, 1H), 7.73 (s, 1H), 7.65-7.50 (m, 4H) EXAMPLES 98 AND 99 The same procedure as in (2) of Example 97 was performed to produce Compounds 98 and 99. (Table Removed) EXAMPLE 100: Preparation of 6-tert-butyl-2-[2-chloro-4-(3-methylpyridin-2-yl)phenyl]-1H-benzoimidazole (Figure Removed) To a solution of 0.46g (3.6mmol) 2-chloro-3- methylpyridine in 20mL 1,2-dimethoxyethane and 20mL dilstilled water were added 2.2g (21.1mmol) Na2CO3, 0.6g (3.0mmol) 3-chloro-4-carboxylphenylboronic acid and 50mg Pd(PPh3)4, followed by stirring the solution for 15 hours in a heat flux condition and concentrating in a vacuum. The aqueous layer was washed with ethyl acetate and adjusted to a pH of 1 with cone. HC1. Thereafter, extraction with ethyl acetate was conducted many times and the organic layer was dried over magnesium sulfate and vacuum concentrated. The concentrate was dissolved in 25mL dimethylformamide and mixed with 0.5g (3.0mmol) 4-tert-butylbenzen-l,2-diamine, 1.2mL (6.0mmol) diisopropylethylamine and 1.3g (7.2mmol) 0- (7-azabenzotriazol-l-yl)-N, N,N',N'-tetramethyleuronium hexafluorophosphate, followed by stirring at room temperature for 16 hours. The concentrate obtained by vaccum concentration was dissolved in ethyl acetate, washed with saturated NaHCO3 and saturated NaCl, and dried over magnesium sulfate, followed by vacuum concentration. The residue thus obtained was dissolved in acetic acid/toluene (15mL/1.5mL), and the solution was stirred at 75°C for 3 hours and vacuum concentrated. Again, this concentrate was dissolved in ethyl acetate, washed with saturated NaHCO3 and saturated NaCl, and dried over magnesium sulfate, followed by vacuum concentration. The residue was separated using column chromatography(developing solvent: chloroform/methanol-30/1) to produce 0.77g of 6-tert-butyl- 2-[2-chloro-4-(3-methylpyridin-2-yl)phenyl]-lH- benzoimidazole (yield 68%}. 1H NMR (CDClaJ £ ; 8.69 (d, 1H}, 8.56-8.52 (m, 1H), 8.06 (s, 1H), 7.73 (s, 1H), 7.53-7.48 (m, 1H), 7.42-7.39 (m, 1H), 7.31-7.27 (m, 1H), 7.18-7.14 (m, 1H), .6.89 (d, 1H), 2.67 (s, 3H), 1.38 (s, 9H) EXAMPLE 101: Preparation of 6-chloro-2-(2-chloro-4-pyridin-2-ylphenyl)-IH-benzoimidazole (Figure Removed) (1) Preparation of 2-chloro-4-pyridin-2-ylbenzoic acid The same procedure as in (1) of Example 1 was performed to produce 2-chloro-4-pyridin-2-ylbenzoic acid (yield 65%). 1H NMR (CD3OD) 6 : 8.63 (s, 1H) , 8.05 (s, 1H), 7.99-7.89 (m, 2H), 7.41-7.39 (m, 2H), 6.65-6.63 (m, 1H) (2) Preparation of 6-chloro-2-(2-chloro-4-pyridin-2- ylphenyl)-IH-benzoimidazole The same procedure as in (3) of Example 1 was performed to produce 6-chloro-2-(2-chloro-4-pyridin-2-ylphenyl)-IH-benzoimidazole (yield 85%). 1H NMR (CDC13) 6 : 8.72 (d, 1H), 8.48 (d, 1H), 8.19 (s, 1H), 8.00 (d, 1H), 7.82-7.68 (m, 2H), 7.62 (s, 1H), 7.59 (d, 1H), 7.31-7.29 (m, 2H) EXAMPLES 102 AND 193 The same procedure as in (2) of Example 101 was performed to produce Compounds 102 and 103. (Figure Removed) EXAMPLE 104: Preparation of 2-[4-(3-chloropyridin-2-yl) naphthalen-1-yl] -6-trifluoromethyl-lH-benzoimidazole (Figure Removed) (1) Preparation of 4-carboxynaphthalene-l-bronic acid To 5 mL of a 25% sodium hydroxide solution was slowly added 0.2g (l.O8mmol) 4-methylnaphthalene-l-boronic acid. During this process, the container was kept in an ice bath. To this, a solution of 0.43g (2.70mmol) potassium permanganate in 5 mL distilled water was slowly added over 1 hour, followed by stirring for an additional 30 min. The solution was withdrawn from the ice bath and stirred at 40°C for an additional 2 hours. The resulting reaction solution was filtered through celite to remove solid matters. To the filtrate was added lOmL ethyl acetate lOmL. After the pH of the aqueous layer was adjusted to 4.0 with a 5.0N HC1 solution, the ethyl acetate layer was separated, dried over anhydrous magnesium sulfate and vacuum concentrated. The residue thus obtained was dissolved in a small amount of methanol and separated using column chromatography(chloroform/methanol=10:l) to produce 0.14g of 4-carboxynaphthalene-l-bronic acid (yield 58%). 1H NMR (CDC13) 6 : 7.68-7.62 (m, 2H), 7.40-7.34 (m, 4H) (2) Preparation of 4-(3-chloropyridin-2- yl)naphthalen-l-carboxylic acid The same procedure as in (1) of Example 1 was performed to produce 4-(3-chloropyridin-2-yl)naphthalen-l-carboxylic acid (yield 60%). XH NMR (CD3OD) 6 : 8.97 (d, 1H), 8.63 (dd, 1H), 8.27 (d, 1H), 8.12 (d, 1H), 7.63-7.49 (m, 4H), 7.40 (d, 1H) (3) Preparation of 2-[4-(3-chloropyridin-2- yl)naphthalen-1-yl]-6-trifluoromethyl-lH-benzoimidazole The same procedure as in (3) of Example 1 was performed to produce 2-[4-(3-chloropyridin-2-yl)naphthalen-1-yl] -6-trifluoromethyl-lH-benzoimidazole (yield 79%). 1H NMR (CDC13) 6 : 8.74 (d, 1H), 8.56 (d, 1H), 8.01- 7.95 (m, 2H) , 7,86 (d, IH), 7.78 (d, IH), 7.53 (d, 1H), 7.47 (d, 2H), 7.40-7.27 (m, 3H) EXAMPLES 105 TO 107 The same procedure as in (3) of Example 1 was performed to produce Compounds 105 to 107. (Figure Removed) EXAMPLE 108: Preparation of 6-tert-butyl-2-[4-(3,5-dichloropyridin-2-yl)naphthalen-1-yl]-1H-benzoimidazole (Figure Removed) (1) Preparation of 4-(3,5-dichloropyridin-2- yl)naphthalen-l-carboxylic acid The same procedure as in (1) of Example 1 was performed to produce 4-(3,5-dichloropyridin-2-yl)naphthalen-l-carboxylic acid (yield 56%). *H NMR (CD3OD) 8 : 8.92 (d, 1H), 8.63 (s, 1H), 8.19 (d, 2H), 7.60-7.55 (m, 1H), 7.49-7.42 (m, 2H), 7.36 (d, 1H) (2) Preparation of 6-tert-butyl-2-[4-(3,5- dichloropyridin-2-yl)naphthalen-1-yl]-1H-benzoimidazole The same procedure as in (3) of Example 1 was performed to produce 6-tert-butyl-2-[4-(3,5-dichloropyridin-2-yl)naphthalen-1-yl]-IH-benzoimidazole (yield 79%). XH NMR (DMSO-d6) 8 : 7.99-7.95 (m, 1H), 7.70-7.64 (m, 1H), 7.45-7.41 (m, 1H), 7.18-7.15 (m, 1H), 6.87-6.46 (m, 7H), 0.57 (s, 9H) The same procedure as in (2) of Example 108 was performed to produce 2-[4-(3,5-dichloropyridin-2- EXAMPLE 109: Preparation of 2-[4-(3,5-dichloropyridin-2-yl)naphthalen-1-yl]-4,6-bistrifluoromethyl-lH-benzoimidazole (Figure Removed) yl)naphthalen-1-yl]-4,6-bistrifluoromethyl-lH-benzoimidazole (yield 60%}. 1H NMR (DMSO-de) 8 : 8.00 (d, IH), 7.68 (s, 1H), 7.50 (d, IH), 7.44-7.40 (m, IH), 7.29-7.25 (m, IH), 6.85-6.63 (m, 5H) EXAMPLE 110: Preparation of 6-tert-butyl-2-[4-(3-chloro-5-trif luoromethylpyridin-2-yl )naphthalen-1-yl]-1H-benzoimidazole (Figure Removed) The same procedure as in Example 100 was performed to produce 6-tert-butyl-2-[4-(3-chloro-5- trifluoromethylpyridin-2-yl)naphthalen-1-yl]-1H-benzoimidazole (yield 56%). 1H NMR (DMSO-de) 6 : 8.36-8.30 (m, 1H), 7.93-7.89 (m, 1H), 7.48-7.44 (m, 1H), 7.28-7.25 (m, 1H), 6.91-6.59 (m, 7H), 0.59 (s, 9H) EXAMPLE 111: Preparation of 2-[4-(3-chloro-5-trifluoromethylpyridin-2-yl)naphthalen-1-yl]-4,6-bistrifluoromethyl-lH-benzoimidazole (Figure Removed) The same procedure as in Example 110 was performed to produce 2- [4- (3-chloro-5-trifluoromethylpyridin-2-yl)naphthalen-l-yl] -4, 6-bistrifluoromethyl-lH-benzoimidazole (yield 55%) . 1H NMR (DMSO-d6) 6 : 8.34 (d, 1H) , 7.91 (s, 1H) , 7.55 (d, 1H), 7.43-7.37 (m, 1H) , 7.27 (d, 1H) , 6.84-6.64 (m, 5H) EXAMPLE 112: Preparation of N-{ 4- [4- (4, 6-bistrifluoromethyl-lH-benzoimidazole-2-yl) naphthalen-1-yl] -2-f luorophenyl} methanesulfonamide (Figure Removed) (1) Preparation of 4- (3-fluoro-4- methanesulfonylaminophenyl) naphthalen-1-carboxylic acid The same procedure as in (1) of Example 1 was performed to produce 4- (3-fluoro-4-methanesulfonylaminophenyl) naphthalen-1-carboxylic acid (yield 43%) . 1H NMR (CD3OD) 8 : 8.92 (d, 1H) , 8.14 (d, 1H) , 7.82 (s, 1H), 7.64-7.58 (m, 2H) , 7.48-7.41 (m, 2H) , 7.29-7.25 (m, 2H) , 3.06 (s, 3H) (2) Preparation of N-{4- [4- (4, 6-bistrifluoromethyl- lH-benzoimidazole-2-yl ) naphthalen-1-yl] -2- fluorophenyl } methanesulfonamide The same procedure as in (3) of Example 1 was performed to produce N-{4-[4- (4,6-bistrifluoromethyl-lH-benzoimidazole-2-yl)naphthalen-1-yl]-2-fluorophenyl}methanesulfonamide (yield 55%). 1H NMR (CD3OD) 8 : 8.43 (d, 1H) , 8.00-7.89 (m, 3H) , 7.70-7.60 (m, 3H) , 7.61-7.52 (m, 2H) , 7.37-7.30 (m, 2H) , 3.11 (s, 3H) EXAMPLE 113: Preparation of 6-trifluoromethyl-2-[4-(3-trifluoromethylpyridin-2-yl)naphthalen-1-yl]-1H-benzoimidazole (Figure Removed) (1) Preparation of 4-(3-trifluoromethylpyridin-2- yl)naphthalen-l-carboxylic acid The same procedure as in (1) of Example 1 was performed to produce 4-(3-trifluoromethylpyridin-2-yl)naphthalen-1-carboxylic acid (yield 60%) . XH NMR (CD3OD) 6 : 8.75 (d, 1H) , 8.35 (d, 1H) , 8.26 (d, 2H), 7.74-7.70 (m, 2H), 7.59-7.54 (m, 2H), 7.25 (d, 1H) (2) Preparation of 6-trifluoromethyl-2-[4-(3- trifluoromethylpyridin-2-yl)naphthalen-1-yl]-1H- benzoimidazole The same procedure as in (3) of Example 1 was performed to produce 6-trifluoromethyl-2-[4-(3-trifluoromethylpyridin-2-yl)naphthalen-1-yl]-1H- benzoimidazole (yield 64%). 1H NMR (CDC13) 8 : 8.60-8.50 (m, 3H) , 8.13-8.11 (m, 1H), 7.91-7.85 (m, 1H) , 7.65-7.62 (m, 1H) , 7.47-7.42 (m, 2H), 7.34-7.30 (m, 2H) , 7.49-7.46 (m, 1H) , 7.02-6.98 (m, 1H) EXAMPLE 114: Preparation of 6-tert-butyl-2-(4-pyridin-2-ylnaphthalen-1-yl)-1H-benzoimidazole (Figure Removed) The same procedure as in Example 100 was performed to produce 6-tert-butyl-2-(4-pyridin-2-ylnaphthalen-l-yl)-1H-benzoiniidazole (yield 57%) . XH NMR (CDC13) 8 : 8.74 (d, 1H) , 7.98 (d, 1H) , 7.88 (d, 1H), 7.78 (d, 2H) , 7.60 (d, 2H) , 7.52-7.40 (m, 6H) , 1.48 (s, 9H) EXAMPLE 115: Preparation of 2-(4-pyridin-2-ylnaphthalen-l-yl)-4,6-bistrifluoromethyl-lH-benzoimidazole (Figure Removed) The same procedure as in Example 114 was performed to produce 2-(4-pyridin-2-ylnaphthalen-l-yl)-4, 6- bistrifluoromethyl-lH-benzoimidazole (yield 47%). (12-7.56 (m, 3H) , 7.64-7.58 (m, 2H), 7.05 (d, 1H) EXAMPLE 116: Preparation of 6-tert-butyl-2-[3-chloro-4-(3- chloropyridin-2-yl)phenyl]-IH-benzoimidazole (Figure Removed) (1) Preparation of 3-chloro-4-(4,4,5,5-tetramethyl- [1,3,2]dioxabororan-2-yl)benzoic acid The same procedure as in (1) of Example 104 was performed to produce 3-chloro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxabororan-2-yl)benzole acid (yield 50%). 1H NMR (CD3OD) 8 : 7.89 (s, 1H) , 7.80 (d, 1H) , 7.65 (d, 1H), 1.37 (s, 12H) (2) Preparation of 3-chloro-4-(3-chloropyridin-2- yl)benzoic acid The same procedure as in (1) of Example 1 was performed to produce 3-chloro-4-(3-chloropyridin-2-yl)benzoic acid (yield 69%) . 1H NMR (CD3OD) 8 : 8.51 (dd, 1H) , 8.04 (d, 1H) , 7.97 (dd, 1H), 7.95 (dd, 1H), 7.45 (dd, 1H), 7.32 (d, 1H) (3) Preparation of 6-tert-butyl-2-[3-chloro-4-(3- chloropyridin-2-yl)phenyl]-IH-benzoimidazole The same procedure as in (3) of Example 1 was performed to produce 6-tert-butyl-2-[3-chloro-4-(3-chloropyridin-2-yl)phenyl] -1H-benzoimidazole (yield 86%). 1H NMR (CDC13) 6 : 8.72 (d, 1H) , 8.48 (d, 1H) , 8.19 (s, 1H), 8.00 (d, 1H), 7.82-7.68 (m, 1H) , 7.62 (s, 1H) , 7.59 (d, 1H), 7.31-7.29 (m, 2H), 1.42 (s, 9H) EXAMPLE 117: Preparation of 2-[3-chloro-4- (3,5-dichloropyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole (Figure Removed) (1) Preparation of 3-chloro-4-(3,5-dichloropyridin-2- yl)benzoic acid The same procedure as in (1) of Example 1 was performed to produce 3-chloro-4-(3,5-dichloropyridin-2-yl)benzoic acid (yield 64%). 1H NMR (CD3OD) 6 : 8.58 (s, 1H) , 8.13 (s, 1H) , 8.10 (d, 1H), 8.00 (d, 1H), 7.36 (d, 1H) (2) . Preparation of 2-[3-chloro-4-(3,5- dichloropyridin-2-yl)phenyl]-6-trifluoromethyl-lH- benzoimidazole The same procedure as in (3) of Example 1 was performed to produce 2-[3-chloro-4-(3,5-dichloropyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole (yield 70%). XH NMR (CD3OD) 6 : 8.56 (s, 1H) , 8.26 (s, 1H) , 8.12 EXAMPLES 118 AND 119 The same procedure as in (2) of Example 117 was performed to produce Compounds 118 and 119. (Table Removed) EXAMPLE 120: Preparation of 2-[3-chloro-4-(3-chloro-5-trifluoromethylpyridin-2-yl) phenyl]-6-trifluoromethyl-lH-benzoimidazole (Figure Removed) (1) Preparation of 3-chloro-4-(3-chloro-5- trifluoromethylpyridin-2-yl)benzole acid The same procedure as in (1) of Example 1 was performed to produce 3-chloro-4- (3-chloro-5-trifluoromethylpyridin-2-yl)benzole acid (yield 69%). 1H NMR (CD3OD) 8 : 8.90 (s, 1H) , 8.39 (s, 1H) , 8.11 (s, 1H), 8.00 (d, 1H), 7.33 (d, 1H) (2) Preparation of 2-[3-chloro-4-(3-chloro-5- trifluoromethylpyridin-2-yl)phenyl]-6-trifluoromethyl-lH- benzoimidazole The same procedure as in (3) of Example 1 was performed to produce 2-[3-chloro-4-(3-chloro-5-trifluoromethylpyridin-2-yl)phenyl] -6-trifluoromethyl-lH-benzoimidazole (yield 80%). XH NMR (CD3OD) 5 : 8.60 (s, 1H) , 8.09 (s, 1H) , 7.99-7.96 (m, 1H), 7.85 (s, 1H), 7.69 (d, 1H), 7.53-7.48 (m, 3H) EXAMPLES 121 AND 122 The same procedure as in (2) of Example 120 was performed to produce Compounds 121 and 122. (Table Removed) EXAMPLE 123: Preparation of N-[2'-chloro-4'-(4-chloro-6-trifluoromethyl-lH-benzoimidazole-2-yl)-3-fluorobiphenyl-4-yl]methanesulfonamide (Figure Removed) (1) Preparation of 3-chloro-4-(3-fluoro-4-methanesulfonylaminophenyl)benzoic acid The same procedure as in (1) of Example 1 was performed to produce 3-chloro-4-(3-fluoro-4-methanesulfonylaminophenyl)benzoic acid (yield 54%). 1H NMR (CD3OD) 8 : 8.06 (s, 1H) , 7.92 (d, 1H) , 7.58 (dd, 1H), 7.40 (d, 1H), 7.34 (s, 1H) , 7.28-7.25 (m, 1H) , 3.06 (s, 3H) (2) Preparation of N-[2'-chloro-4' -(4-chloro-6-trifluoromethyl-lH-benzoiniidazole-2-yl)-3-fluorobiphenyl-4-yl]methanesulfonamide The same procedure as in (3) of Example 1 was performed to prodube N-[2'-chloro-4' -(4-chloro-6-trifluoromethyl-lH-benzoimidazole-2-yl)-3-fluorobiphenyl-4-yl]methanesulfonamide (yield 60%). 1H NMR (CD3OD) 6 : 8.40 (s, 1H), 8.21 (d, 1H), 7.88 (s, 1H), 7.42-7.34 (m, 3H), 7.42-7.34 (m, 2H), 3.08 (s, 3H) EXAMPLE 124: Preparation of N-[4'-(4,6-bistrifluoromethyl-lH-benzoimidazole-2-yl)-2' -chloro-3-fluorobiphenyl-4-yl]methanesulfonamide (Figure Removed) The same procedure as in (2) of Example 123 was performed to produce N-[4'- (4,6-bistrifluoromethyl-lH-benzoimidazole-2-yl)-2' -chloro-3-fluorobiphenyl-4-yl]methanesulfonamide (yield 56%). 1H NMR (CD3OD) 8 : 8.43 (s, 1H), 8.25 (d, 1H), 8.18 (s, 1H), 7.83 (s, 1H), 7.67-7.61 (m, 2H), 7.43-7.34 (m, 2H), 3.10 (s, 3H) EXAMPLE 125: Preparation of 2-(3-chloro-4-pyridin-2-ylphenyl)-6-trifluoromethyl-lH-benzoimidazole (Figure Removed) (1) Preparation of 3-chloro-4-pyridin-2-ylbenzoic acid The same procedure as in (1) of Example 1 was performed to produce 3-chloro-4-pyridin-2-ylbenzoic acid (yield 68%). XH NMR (CD3OD) 8 : 8.66 (d, 1H), 8.14 (s, 1H), 8.05 (d, 1H), 7.99 (dd, 1H), 7.71 (d, 1H), 7.64 (d, 1H), 7.48 (dd, 1H) (2) Preparation of 2-(3-chloro-4-pyridin-2-ylphenyl)- 6-trifluoromethyl-lH-benzoimidazole The same procedure as in (3) of Example 1 was performed to produce 2-(3-chloro-4-pyridin-2-ylphenyl)-6-trifluoromethyl-lH-benzoimidazole (yield 88%). 1H NMR (DMSO-de) 6 : 7.93-7.89 (m, 1H), 7.63-7.56 (m, 1H), 7.50-7.44 (m, 1H), 7.19-7.11 (m, 2H), 7.02-6.95 (m, 3H), 6.76 (s, 1H) , 6.67-6.62 (m, 1H) EXAMPLES 126 TO 130 The same procedure as in (2) of Example 125 was performed to produce Compounds 126 to 130. (Table Removed) EXAMPLE 131: Preparation of 2-[3-chloro-4-(3- trifluoromethylpyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole (Figure Removed) (1) preparation of 3-chloro-4-(3- trifluoromethylpyridin-2-yl) benzole acid The same procedure as in (1) of Example 1 was performed to produce 3-chloro-4-(3-trifluoromethylpyridin-2-yl)benzoic acid (yield 76%). 1H NMR (CD3OD) 8 : 7.98-7.91 (m, 3H) , 7.60-7.57 (m, 2H), 7.46 (d, 1H) (2) Preparation of 2-[3-chloro-4- (3- trif luoromethylpyridin-2-yl) phenyl] -6-trifluoromethyl-lH- benzoimidazole The same procedure as in (3) of Example 1 was performed to produce 2-[3-chloro-4- (3-trif luoromethylpyridin-2-yl ) phenyl] -6-trifluoromethyl- 1H-benzoimidazole (yield 89%) . JH NMR (CDC13) 5 : 8.02 (s, 1H) , 7.97-7.93 (m, 1H) , 7.85 (s, 1H), 7.64 (d, 1H) , 7.44 (d, 2H) , 7.42-7.37 (m, 3H) EXAMPLES 132 TO 134 The same procedure as in (2) of Example 131 was performed to produce Compounds 132 to 134. (Table Removed) EXAMPLE 135: Preparation of 2-[3-chloro-4-(3-methylpyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole (Figure Removed) The same procedure as in Example 100 was performed to produce 2- [3-chloro-4-(3-methylpyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole (yield 48%). XH NMR (CDC13) 8 : 8.01 (s, 1H) , 7.96-7.91 (m, 1H) , 7.84 (s, 1H), 7.62 (d, 1H), 7.44 (d, 1H) , 7.37-7.34 (m, 4H), 2.70 (s, 3H) EXAMPLE 136: Preparation of 3-chloro-6'-(6-trifluoromethyl lH-benzoimidazole-2-yl)-[2,3' ]bipyridine (Table Removed) 3-chloro-2 ' 6-methylpyridin-3-yl)pyridine To a solution of O.Sg (3.6mmol) 2,3-dichloropyridine in 20mL 1,2-dimethoxyethane and 20mL distilled water were added 2.2g (21.1mmol) Na2C03, 0.41g (3.0mmol) 2-methylpyridine-5-boronic acid and 50mg Pd(PPh3)4, followed by stirring for 18 hours in a heat flux condition. After being cooled to room temperature, the solution was 50% concentrated in a vacuum condition. The aqueous layer was washed with ethyl acetate. Thereafter, the organic layer was dried over magnesium sulfate and vacuum concentrated. The concentrate was separated using column chromatography (developing solvent: ethyl acetate/hexane=l/10) to produce 0.56g of 3-chloro-2-(6-methylpyridin-3-yl)pyridine (yield 80%) . aH NMR (CDC13) 8 : 8.91 (d, 1H) , 8.63 (dd, 1H) , 7.99 (dd, 1H), 7.83 (dd, 1H) , 7.49-7.47 (m, 1H) , 7.30-7.27 (m, 1H), 2.65 (s, 3H) (2) Preparation of 5-(3-chloropyridin-2-yl)pyridin-2-carboxylic acid The same procedure as in (1) of Example 104 was performed to produce 5-(3-chloropyridin-2-yl)pyridin-2-carboxylic acid (yield 69%). 1H NMR (CDC13) 6 : 9.03 (d, 1H), 8.67 (dd, 1H), 8.36-8.32 (m, 2H), 7.88 (dd, 1H) , 7.39-7.34 (m, 1H) (3) Preparation of 3-chloro-6'-(6-trifluoromethyl-lH-benzoimidazole-2-yl)-[2, 3' ]bipyridine The same procedure as in (3) of Example 1 was performed to produce 3-chloro-6'-(6-trifluoromethyl-lH-benzoimidazole-2-yl)-[2, 3' ]bipyridine (yield 92%). 1H NMR (CDC13) 8 : 9.04 (d, 1H) , 8.65 (dd, 1H), 8.58 (d, 1H), 8.35 (dd, 1H), 8.00 (s, 1H) , 7.88 (dd, 1H) , 7.78 (s, 1H), 7.56 (dd, 1H), 7.32 (dd, 1H) EXAMPLES 137 TO 145 The same procedure as in (3) of Example 136 was performed to produce Compounds 137 to 145. (Table Removed) EXAMPLE 146: Preparation of 3-chloro-6'-(6-morpholin-4-yl- lH-benzoimidazole-2-yl)-[2, 3' ]bipyridine (Figure Removed) The same procedure as in Example 17 was performed to produce 3-chloro-6'-(6-morpholin-4-yl-lH-benzoimidazole-2-yl)-[2,3']bipyridine (yield 72%) . :H NMR (CD3OD) 6 : 9.21 (dd, 1H) , 8.69 (d, 1H) , 8.48 (dd, 1H) , 8.35 (d, 1H) , 8.09 (d, 1H) , 7.73 (d, 1H) , 7.55- 7.50 (m, 1H), 7.45 (dd, 1H) , 7.23 (d, 1H) , 3.92-3.88 (m, 4H), 3.32-3.29 (m, 4H) EXAMPLES 147 TO 150 The same procedure as in Example 146 was performed to produce Compounds 147 to 150. (Table Removed) EXAMPLE 151: Preparation of 3,5-dichloro-6'-(6-trifluoromethyl-lH-benzoimidazole-2-yl)-[2,3']bipyridine (Figure Removed) (1) Preparation of 3,5-dichloro-2-(6-methylpyridin-3-yl)pyridine The same procedure as in (1) of Example 136 was performed to produce 3,5-dichloro-2-(6-methylpyridin-3- yl)pyridine (yield 72%> , 8.76 (s, 1H), 8.67 (s, 1H), 8.20- 8.11 (m, 2H), 7.47-7.43 (m, 1H), 2.61 (s, 3H) (2) The same procedure as in Example 100 was performed to produce 3,5-dichloro-6'-(6-trifluoromethyl-lH-benzoimidazole-2-yl)-[2,3' ]bipyridine (yield 65%). 1H NMR (CDC13) 6 : 9. 05 (s, 1H), 8.81 (d, 1H), 8.62 (s, 1H), 8.37 (d, 1H), 8.10 (s, 1H), 7.90 (s, 1H), 7.86 (d, 1H), 7.64 (d, 1H) EXAMPLES 152 TO 155 The same procedure as in (2) of Example 151 was performed to produce Compounds 152 to 155. (Table Removed) EXAMPLE 156: Preparation of 6' -(4,6-bistrifluoromethyl-lH-benzoimidazole-2-yl ) -3-chloro-5-trifluoromethyl-[2,3' ]bipyridine (Figure Removed) (1) Preparation of 3-chloro-5-trifluoromethyl-2-(6- methylpyridin-3-yl)pyridine The same procedure as in (1) of Example 136 was performed to produce 3-chloro-5-trifluoromethyl-2-(6-methylpyridin-3-yl)pyridine (yield 79%). 1H NMR (CD3OD) 6 : 8.94 (s, 1H), 8.82 (s, 1H), 8.39 (s, 1H), 8.16 (d, 1H), 7.4-8 (d, 1H) , 2.63 (s, 3H) (2) Preparation of 5-(3-chloro-5- trifluoromethylpyridin-2-yl)pyridin-2-carboxylic acid The same procedure as in (1) of Example 104 was performed to produce 5-(3-chloro-5-trifluoromethylpyridin-2-yl) pyridin-2-carboxylic acid (yield 70%). 1H NMR (CD3OD) 6 : 9.05-8.95 (m, 2H), 8.42-8.38 (m, 2H), 7.66-7.62 (m, 1H) (3) Preparation of 6'-(4,6-bistrifluoromethyl-lH- benzoimdazole-2-yl) -3-chloro-5-trifluoromethyl-[2,3']bipyridine The same procedure as in (3) of Example 1 was performed to produce 6'-(4,6-bistrifluoromethyl-lH-benzoimidazole-2-yl)-3-chloro-5-trifluoromethyl-[2,3']bipyridine (yield 73%). 1H NMR (CDC13) 6 : 9.15 (s, 1H), 8.93 (s, 1H), 8.56 (d, 1H), 8.39-8.33 (m, 2H), 8.13 (s, 1H), 7.85 (s, 1H) EXAMPLE 157: Preparation of 6'-(6-methoxy-lH- benzoimidazole-2-yl)-3-chloro-5-trifluoromethyl-[2,3']bipyridine pi (Figure Removed) The same procedure as in (3) of Example 156 was performed to produce 6'-(6-methoxy-lH-benzoimidazole-2-yl)-3-chloro-5-trifluoromethyl-[2,3']bipyridine (yield 91%). 1H NMR (CDC13) 6 : 8.91 (s, 1H), 8.25-8.20 (m, 1H), 8.12 (s, 1H), 7.57 (d, 1H), 7.36 (s, 1H), 7.36-7.28 (m, 3H), 3.94 (s, 3H) EXAMPLE 158: Preparation of 3-trifluoromethyl-6'-(6-trifluoromethyl-lH-benzoimidazole-2-yl)-[2,3']bipyridine (Figure Removed) (1) Preparation of 3-trifluoromethyl-2- (6- methylpyridin-3-yl ) pyridine The same procedure as in (1) of Example 136 was performed to produce 3-trifluoromethyl-2- (6-methylpyridin-3-yl) pyridine (yield 82%) . 1H NMR (CDC13) 6 : 8.88 (d, 1H) , 8.67 (s, 1H) , 8.12 (dd, 1H) , 7.76 (dd, 1H) , 7.54-7.49 (m, 1H) , 7.29-7.28 (m, 1H) , 2.66 (s, 3H) (2) Preparation of 5- (3-trifluoromethylpyridin-2- yl)pyridin-2-ylcarboxylic acid The same procedure as in (1) of Example 104 was performed to produce 5- (3-trifluoromethylpyridin-2-yl)pyridin-2-ylcarboxylic acid (yield 75%) . XH NMR (CD3OD) 5 : 8.92-8.89 (m, 1H) , 8.79 (s, 1H) , 8.34-8.27 (m, 2H) , 8.15 (s, 1H) , 7.73-7.68 (m, 1H) (3) Preparation of 3-trifluoromethyl-6' - (6- trifluoromethyl-lH-benzoimidazole-2-yl) -[2, 3' Jbipyridine The same procedure as in (3) of Example 1 was performed to produce 3-trif luoromethyl-6'- (6-trifluoromethyl-lH-benzoimidazole-2-yl) -[2,3' Jbipyridine (yield 94%) . 1H NMR (CDC13) 6 : 8.94 (d, 1H) , 8.84 (s, 1H) , 8.61 (d, 1H), 8.19 (d, 1H), 8.11 (d, 1H), 8.10 (s, 1H) , 8.08 (d,1H), 7.61-7.54 (m, 2H) EXAMPLES 159 TO 168 The same procedure as in (3) of Example 158 was performed to produce Compounds 159 to 168. (Table Removed) EXAMPLE 169: Preparation of 6'-(6-morpholin-4-yl-lH- benzoimidazo-2-yl) --3-trifluoromethyl- [2, 3' ]bipyridine (Figure Removed) The same procedure as in Example 17 was performed to produce 6'-(6-morpholin-4-yl-lH-benzoimidazo-2-yl)-3-trifluoromethyl-[2,3']bipyridine (yield 67%). 1H NMR (CD3OD) 6 : 8.90 (d, 1H), 8.80 (s, 1H), 8.33 (dd, 1H), 8.27 (dd, 1H), 8.07 (dd, 1H), 7.75-7.81 (br, 1H), 7.66 (dd, 1H), 7.65-7.55 (br, 1H), 7.41 (dd, 1H), 3.88-3.92 (m, 4H), 3.32-3.29 (m, 4H) EXAMPLE 170: Preparation of 6'-(4-morpholin-4-yl-6-trifluorornethyl-lH-benzoimidazole-2-yl)-3-trifluoromethyl-[2,3']bipyridine (Figure Removed) The same procedure as in Example 169 was performed to produce 6'-(4-morpholin-4-yl-6-trifluoromethyl-lH-benzoimidazole-2-yl)-3-trifluoromethyl-[2,3']bipyridine (yield 67%). 1H NMR (CDCl3) 6 : 10.94 (s, 1H), 8.92 (d, 1H), 8.79 (s, 1H), 8.53 (d, 1H), 8.15 (d, 1H), 8.06 (dd, 1H), 7.56-7.52 (m, 1H), 7.09 (s, 1H), 6.82 (s, 1H), 4.06-4.00 (m, 4H), 3.72-3.67 (m, 4H) EXAMPLE 171: Preparation of 6'-(6-chloro-lH-benzoimidazole-2-y1)-[2,3' ]bipyridine (Figure Removed) (1) Preparation of 2-(6-methylpyridin-3-yl)pyridine The same procedure as in (1) of Example 136 was performed to produce 2-(6-methylpyridin-3-yl)pyridine (yield 67%) . 1H NMR (CDC13) 6 : 9.08 (d, 1H), 8.72 (dd, 1H), 8.24 (dd, 1H), 7.79-7.75 (m, 2H), 7.62-7.45 (m, 1H), 7.30-7.27 (m, 1H), 2.64 (s, 3H) (2) Preparation of 5-(pyridin-2-yl)pyridin-2- carboxylic acid The same procedure as in (1) of Example 104 was performed to produce 5-(pyridin-2-yl)pyridin-2-carboxylic acid (yield 77%). 1H NMR (CD3OD) 6 : 9.30 (s, 1H), 8.73 (d, 1H), 8.62 (d, 1H), 8.30 (d, 1H), 8.07-7.98 (m, 2H), 7.49 (d, 1H) (3) Preparation of 6'-(6-chloro-lH-benzoimidazole-2- yl)-[2,3']bipyridine The same procedure as in . (3) of Example 1 was performed to produce 6'-(6-chloro-lH-benzoimidazole-2-yl)-[2,3']bipyridine (yield 90%). XH NMR (CDC13) 8 : 7.80-7.78 (m, 1H), 7.70-7.67 (m, 1H), 7.62-7.58 (m, 1H), 7.46-7.45 (m, 1H), 7.32-7.13 (m, 6H) EXAMPLES 172 AND 173 The same procedure as in (3) of Example 171 was performed to produce Compounds 172 and 173. (Figure Removed) EXAMPLE 174: Preparation of 6-tert-butyl-2-(6-naphthalen-l-ylpyridin-3-yl)-1H-benzoimidazole (Figure Removed) The same procedure as in Example 100 was performed to produce 6-tert-butyl-2-(6-naphthalen-l-ylpyridin-3-yl)-1H-benzoimidazole (yield 53%) . 1H NMR (CD3OD) 6 : 9.40 (s, 1H) , 8.62 (d, 1H) , 8.00-7.95 (m, 5H), 7.58-7.46 (m, 6H) , 1.28 (s, 9H) EXAMPLE The same procedure as in Example 174 was performed to produce Compounds 175 to 177. (Figure Removed) The same procedure as in (3) of Example 1 was performed to produce 2-(4-pyrrol-l-ylphenyl]-6- EXAMPLE 178: Preparation of 2-(4-pyrrol-l-ylphenyl]-6-trifluoromethyl-lH-benzoimidazole trifluoromethoxy dazole., (yield 77%). 1H δ : (1 : 8.12 (d, 2H, J=8.7Hz), 7.92 (s, 1H), 7.69 (d, 1H, J=8.6Hz), 7.54-7.49 (m, 3H) , 7.15-7.14 (m, 2H), 6.40-6.38 (m, 2H) (Table Removed) EXAMPLES 179 TO 200 (Table Removed) The same procedure as in Example 178 was performed to produce Compounds 179 to 200. en co (CD3OD) 5 : 8.35 (d, 2H) ,8.05 (d, 2H), 7.94 (d,2H), 7.82-7.77 (m, 2H),7.71-7.66 (m, 3H), 7.54 (d, 1H), 1.54 (s, 9H) EXAMPLE 201: Preparation of 2-[4-(3-chloropyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole chloride SOOmg (1.34mmol) of 2-[4-(3-chloropyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole was dissolved in l0mL of diethylether, followed by stirring for 30 min at a subzero temperature. After saturation with gaseous hydrochloric acid, the solution was stirred for an additional one hour at a subzero temperature. A white precipitate thus obtained was filtered and dried for 24 hours in a vacuum condition to give 513mg of 2-[4-(3-chloropyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole chloride. 1H NMR (CD3OD) 8 : 8.75 (d, 1H) , 8.38 (d, 2H) , 8.29 (d, 1H), 8.23 (s, 1H), 8.13 (d, 2H), 8.10 (d, 1H), 7.97 (d, 1H), 7.70(dd, 1H) mp : 291 - 293°C EXAMPLE 202: Preparation of 6-tert-butyl-2-[4-(3-chloropyridin-2-yl)phenyl]-IH-benzoimidazole chloride The same procedure as in Example 201 was performed to produce 500 mg of 6-tert-butyl-2-[4-(3-chloropyridin-2-yl)phenyl]-IH-benzoimidazole chloride. 1R NMR (CD3OD) 8 : 8.73 (d, 1H) , 8.30 (d, 2H) , 8.26 (d, 1H), 8.10 (d, 2H), 7.83 (d, 2H) , 7.81 (s, 1H) , 7.67 (dd, 1H), 1.47 (s, 9H) mp : 189 ~ 190°C EXAMPLE 203: Preparation of 6-tert-butyl-2-[4-(3-chloropyridin-2-yl)naphthalen-1-yl]-1H-benzoimidazole chloride The same procedure as in Example 201 was performed to produce 510 mg of 6-tert-butyl-2-[4-(3-chloropyridin-2-yl)naphthalen-1-yl]-IH-benzoimidazole chloride. 1H NMR (CD3OD) 6 : 8.68 (d, 1H) , 8.20 (d, 1H) , 8.16-8.11 (m, 2H), 7.83-7.72 (m, 5H) , 7.66-7.62 (m, 2H) , 7.54 (d, 1H), 1.41 (s, 9H) mp : 208 - 214°C EXAMPLE 204: Preparation of 6'- (4,6-bistrifluoromethyl-lH-benzoimidazole-2-yl)-3-chloro[2,3']bipyridine chloride The same procedure as in Example 201 was performed to produce 520 mg of 6'-(4,6-bistrifluoromethyl-lH-benzoimidazole-2-yl)-3-chloro[2,3']bipyridine chloride. XH NMR (CD3OD) 8 : 9.03 (s, 1H) , 8.61-8.53 (m, 2H) , 8.30 (d, 1H), 8.15(s, 1H), 8.03 (d, 1H) , 7.77 (s, 1H) , 7.47-7.43 (m, 1H) mp : 133 - 135°C EXAMPLE 205: Preparation of 3-trifluoromethyl-6'-(6-trifluoromethyl-lH-benzoimidazole-2-yl)-[2,3']bipyridine chloride The same procedure as in Example 201 was performed to produce 495 mg of 3-trifluoromethyl-6' -(6-trifluoromethyl-lH-benzoimidazole-2-yl)-[2, 3']bipyridine chloride. 1H NMR (CD3OD) 6 : 9.00 (s, 1H) , 8.91 (d, 1H) , 8.46 (d, 1H), 8.35-8.28 (m, 2H) , 8.17 (s, 1H) , 8.04 (d, 1H) , 7.90 (d, 1H), 7.73-7.69 (m, 1H) mp : 234 - 240°C EXAMPLE 206: Preparation of 6-tert-butyl-2-[4-(3-chloropyridin-2-yl)phenyl]-1H-benzoimidazole sodium salt A solution of lOOmg (0.28mmol) of 6-tert-butyl-2-[4-(3-chloropyridin-2-yl)phenyl]-1H-benzoimidazole in 2.8mLof 0.1N sodium hydroxide and 0.5mL of methanol was stirred at room temperature for 30 min and vacuum concentrated to produce 107 mg of 6-tert-butyl-2-[4-(3-chloropyridin-2-yl)phenyl]-1H-benzoimidazole sodium salt as a pale yellow precipitate. 1H NMR ,60 (d, 1H), 8.22 (d, 2H) , 8.04 (d, 1H), 7.85 (d, 2H), 7.65 (s, 1H) , 7.57 (d, 1H) , 7.48-7.38 (m, 2H), 1.43 (s, 9H) . mp : 317 - 324°C EXAMPLE 207: Preparation of 3-trifluoromethyl-6'-(6-trifluoromethyl-lH-benzoimidazole-2-yl)-[2, 3'Jbipyridine sulfate l.Og (2.45mmol) of a pyridine compound was dissolved in 30 ml of acetone and stirred for 30 min at a subzero temperature. To this, a dilution of 0.16 mL (2.94mmol) of sulfate in 20 mL of acetone was dropwisely added over 10 min. Stirring for one hour at a subzero temperature produced a white precipitate which was then vacuum dried to produce 1.22 g of 3-trifluoromethyl-6' -(6-trifluoromethyl-lH-benzoimidazole-2-yl) -[2, 3']bipyridine sulfate. XH NMR (CD3OD) 6 : 9.07 (s, 1H) , 8.99 (d, 1H) , 8.55 (d, 1H), 8.46 (d, 1H), 8.37 (dd, 1H), 8.26 (s, 1H) , 8.12 (d, 1H), 7.97 (d, 1H), 7.80-7.74 (m, 1H) EXAMPLE 208: Preparation of 3-trifluoromethyl-6'-(6-trifluoromethyl-lH-benzoimidazole-2-yl)-[2, 3']bipyridine phosphate l.Og (2.45mmol) of a bipyridine compound was dissolven in 30mL of and stirred for 30 min at a freezing temperature. To this, a dilution of 0.16 mL (2.94mmol) of phosphoric acid in 20 mL of acetone was added dropwise over 10 min. Stirring for one hour at a freezing temperature produced a white precipitate which was then vacuum dried to produce 1.23 g of 3-trifluoromethyl-6'- (6-trifluoromethyl-lH-benzoimidazole-2-yl)-[2,3' ]bipyridine phosphate. 1H NMR (CD3OD) 5: 8.92 (dd, 1H) , 8.85 (s, 1H) , 8.45 (d, 1H), 8.34 (d, 1H), 8.14 (dd, 1H) , 8.00 (s, 1H) , 7.83 (d, 1H), 7.72-7/70 (m, 1H) , 7.59 (d, 1H) EXAMPLE 209: Preparation of 3-trifluoromethyl-6'-(6-trifluoromethyl-lH-benzoimidazole-2-yl)-[2,3']bipyridine methanesulfonate l.Og (2.45mmol) of a bipyridine compound was dissolved in 30mL of diethylether and stirred for 30 min under a glacial condition. To this, a dilution of 0.19mL (2.94mmol) of methanesulfonic acid in 20 mL of diethylether was added dropwise over 10 min. Stirring for one hour at a freezing temperature produced a white precipitate which was then vacuum dried to produce 1.25 g of 3-trifluoromethyl-6'- (6-trifluoromethyl-lH-benzoimidazole-2-yl)-[2,3']bipyridine methanesulfonate. XH NMR (CD3OD) 6 : 9.05 (s, 1H) , 8.96 (d, 1H) , 8.52 (d, 1H), 8.41-8.32 (m, 2H), 8.24 (s, 1H) , 8.10 (d, 1H) , 7.95 (d, 1H), 7.76 (dd, 1H), 2.72 (s, 3H) EXAMPLE 210: Preparation of 3-trifluoromethyl-6'-(6-trifluoromethyl-lH-benzoimidazole-2-yl)-[2,3']bipyridine benzenesulfonate 1. Og (2.45mmol) of a bipyridine compound was dissolved in 30mL of diethylether and stirred for 30 min at a freezing temperature. To this, a dilution of 0.85 rag (5.39mmol) of benzenesulfonic acid in 20 mL of diethylether was added dropwise over 10 min. Stirring for one hour at a freezing temperature produced a white precipitate which was then vacuum dried to produce 1.39 g of 3-trifluoromethyl-6'-(6-trifluoromethyl-lH-benzoimidazole-2-yl)-[2,3']bipyridine benzenesulfonate. 1H NMR (CD3OD) 5 : 9.07 (s, 1H) , 9.00 (d, 1H) , 8.53 (d, 1H), 8.49 (d, 1H), 8.31 (d, 2H), 8.23 (s, 1H), 8.10 (d, 1H), 7.97 (d, 1H), 7.84-7.80 (ra, 6H), 7.44-7.38 (m, 7.5H) EXPERIMENTAL EXAMPLE 1: Assay for Inhibitory Activity against Vanilloid Receptor 1) Preparation of test compounds Each of the compounds synthesized in the examples were dissolved in dimethyl sulfoxide (DMSO) at a concentration sodium tor use in the assay for inhibitory activity against, patch clamp activity, the solutions were diluted to a concentration of 1 µM with the same physiological saline as in the pipette solution of Table 1, below. 2) Assay for inhibitory activity against VR1 patch clamp activity In this experiment, changes in VR1 activity were recorded in current using an electrophysiological technique. For use in this experiment, a rat TRPV1 cDNA was transfected into a subcultured HEK293 strain with the aid of lipofectamin. The rat TRPV1 gene-transfected HEK293 cells were detached from the cell culture dishes with trypsin and distributed on a patch clamp recording chamber. A cover glass slip on the bottom of the patch clamp recording chamber was treated for 15 min or longer with a 50% poly-L-lysine solution so that the HEK cells would readily adhere thereto. Cellular membranes wer ruptured at room temperature (~25°C) from randomly selected HEK cells to perform an inside-out patch clamp technique. 10 µM of capsaicin was fed into the chamber (cytoplasmic side) to activate a capsaicin current through the VR1. When the capsaicin current reached a stable stage, each compound was added along with in the of capeaicin to record the inhibitory activity of the completes computers with regard to the current. The inhibition was expressed as percentages. Because the capsaicin current showed rapid run-down in the presence of calcium ions across the membrane, experimental solutions comprising the ion compositions of Table 1 were used to prevent the run-down and record the inhibitory activity of effective compounds. TABLE 1. Experimental Solution Composition for Capsaicin Current Recordings (Table Removed) Detected current was amplified using a Digidata 1200B A/D converter and an Axopatch ID amplifier (Axon instruments Inc.), and the data were recorded and analyzed with the aid of a computer. The inhibitory activity of each compound was expressed as a percentage relative to the capsaicin current immediately before the administration of each compound. TABLE 2. Assay for Inhibitory Activity of Test Compounds Against VR1 Activity (Table Removed) EXPERIMENTAL EXAMPLE 2: Calcium Influx of Vanilloid Receptor •Experiments for calcium influx were performed to measure the activity of the compounds as antagonists. 1) Cell culture The cell strain hVRl-HEK293 is the human embryonic kidney(HEK) 293 Tet-on cell transfected with a human vanilloid-1 gene (pTRE2hyg-hVRl, 7.8kb), which is capable of controlling the expression of VR1 according to the administration of deoxycycline, a tetracycline derivative analog. In a medium supplemented with deoxycycline two days before calcium influx experiments, the cell strain was cultured to induce the expression of VR1. After being grown to a confluency of about 80% in T75 flasks, hVRl-HEK293 was detached from the flask using trypsin. Cells harvested by centrifugation were suspended in a medium supplemented with lµg/mL of deoxycycline and diluted to a density of 2-4 x 105 cells/ml, after which a 100 µL aliquot of the cell suspension was added to each well of 96 well black plates. Before the measurement of calcium influx, the cells were incubated for two days at 370C in a 5% CO2 incubator. 2) Preparation of compound samples For use in calcium influx experiments, each compound was dissolved in dimethyl sulfoxide (DMSO). 3) Measurement of calcium influx To measure an intracellular calcium influx, cells were incubated at 37°C for 90 min in a medium containing the calcium indicator Fluo-3/AM so as to allow the fluorescent dye to. penetrate into the cells. Then, the cells were washed three times with D-PBS (Dulbecco's phosphate buffered saline) containing lOmM HEPES to remove the fluorescent dye which remained outside. 193µL aliquot of D-PBS was added to each well, followed by the addition of various c'oncentrations of compounds thereto. In order to measure the antagonistic activity of the compounds, calcium influx was induced by treatment with luM capsaicin. The inhibitory effect of each compound on luM capsaicin-induced intracellular ..calcium influx according to compound concentration was measured using a fluorescent analyzer and the data thus obtained were analyzed on the basis of the Hill's equation. 4) Measurement results TABLE 3: Inhibitory Activity of Compounds Against Calcium Influx (Table Removed) EXPERIMENTAL EXAMPLE 3: Assay for Analgesic Effect A PBQ-induced writhing test was conducted in mice to assay for the analgesic effect of the novel compounds. Five-week-old ICR male mice were treated with PBQ (phenyl-p-quinone, 0.02%). A suspension of 20 mg of test material in 10 mL of physiological saline was used per kg of weight of mice. Test materials in combination with a carrier were orally administered one hour before the intraabdominal injection of PBQ in a dose of 10 mL per kg weight. From 5 min after the injection, individual mice in each test group were measured for numbers of writhes at regular intervals of 10 min. Analgesic effects of test compounds were expressed as percentages of the decrease in number of writhes compared to a control. [% Inhibition=(Control administered with carrier alone '- Group administerd with test material)/control administered with carrier alone X 100] TABLE 4. Analgesic Effects of Test Compounds (Tabale Removed) EXPERIMENTAL TEST 4: Toxicity Test The novel compounds were assayed for acute oral toxicity in mice. To four groups of 10 ICR lineage male mice, the compounds of the present invention, 2-[4-(3-chloropyridin-2-yl) -phenyl] --6-trifluorcrnethyl-lH-benzoimidazole (1), 6-tert-butyl-2-[4-(3-chloropyridin-2-yl)phenyl]-1H-benzoimidazole(3), N-[4' -(4,6-bistrifluoromethyl-lH-benzoimidazole-2-yl)-3-fluorobiphenyl-4- yl]methanesulfonamide(29), 4-bromo-6-(trifluoromethyl)-2- (4-(3-(trifluoromethyl)pyridin-2-yl)phenyl)-1H- benzoimidazole(36), 6-tert-butyl-2-[4-(3-chloropyridin-2- yl)naphthalen-l-yl]-lH~benzoimidazole(105), 3- trifluoromethyl-6' -(6-trifluoromethyl-lH-benzoimidazole-2- yl)-[2,3']bipyridine(158), 6-bromo-2-(5-(3- (trifluoromethyl)pyridin-2-yl)pyridin-2-yl)-1H-benzoimidazole(165) and 6'-(6-morpholin-4-yl-lH-benzoimidazole-2-yl)-3-trifluoromethyl- [2,3']bipyridine(169) were orally administered at doses of zero mg/kg for control, and 125, 250 and 500 mg/kg for test groups, and observations were made of the death, clinical symptoms, and weight changes, and microscopic diagnosis of the animals for 14 days. None of the mice to which the compounds of interest were administered died or differed from the control with respect to clinical symptoms, weight change, and microscopic diagnosis, indicating that the compounds of the present invention are safe. Industrial Applicability As described hereinbefore, the compounds of the present invention are useful in the prevention and treatment of pain, acute pain, chronic pain, neuropathic pain, postoperative pain, migraines, arthralgia, neuropathy, nerve injury, diabetic neuropathy, neurological illness, neurodermatitis, strokes, bladder hypersensitivity, irritable bowel syndrome, respiratory disorders such as asthma, chronic obstructive pulmonary disease, etc., burns, psoriasis, itching, vomiting, irritation of the skin, eyes, and mucous membranes, gastric-duodenal ulcers, inflammatory intestinal diseases, and inflammatory diseases. Although the preferred embodiments of the present invention have been disclosed for illustrative purposes, those skilled in the art will appreciate that various modifications, additions and substitutions are possible, without departing from the scope and spirit of the invention as disclosed in the accompanying claims. We Claim: 1. A benzoimidazole compound represented by the following Chemical Formula 1, a pharmaceutically acceptable salt thereof, or isomers thereof: (Formula Removed) Wherein R1 is cycloalkyl, pyridine, pyrimidine, pyrazole, pyrazine, phenyl, benzyl, imidazole, morpholine, benzodioxole, benzothiazole, benzoimidazole, indole, pyrazolone, thiophene, furan, thiazole, naphthalene, isothiazole, pyridazine, oxazole, isooxazole, triazole, oxodiazole, thiadiazole, indazole, pyrrolidine, chromonyl, piperidine, morpholinethyl, dihydropyrazole or pyrrole group which is non-substituted or substituted with one or more Ra; or (CH2)pAr group, Each Ra is independently selected from among a lower alkyl having 1 to 8 carbon atoms; a lower alkenyl having 2 to 6 carbon atoms; a lower alkoxy having 1 to 8 carbon atoms; a haloalkyl having 1 to 6 carbon atoms; a haloalkoxy having 1 to 6 carbon atoms; a halogen atom; a nitro; a hydroxyl; a cyano; or an amino or amide or a sulfonamide group which is mono- or di-substituted with an alkyl having 1 to 6 carbon atoms or is non-substituted, A is O, NH, NHCO, CO, CO2, SO, SO2, CH2 or NHSO2, n is an integer equal to 0 or 1, W is N or CR3, X is N or CR4, R2 is hydrogen; R3 and R4 may be the same or different, and are independently hydrogen; a lower alkyl having 1 to 8 carbon atoms; a lower alkenyl having 2 to 6 carbon atoms; a lower alkoxy having 1 to 6 carbon atoms; a haloalkyl having 1 to 6 carbon atoms; a haloalkoxy having 1 to 6 carbon atoms; a halogen atom; nitro; hydroxy; cyano; sulfanyl; sulfone; sulfoxide; sulfonamide; urea; carbamate; carbonate; ketone; ester; carboxylic acid; an amino or amide group which is mono- or di-substituted with an alkyl having 1 to 3 carbon atoms or is non-substituted; or a phenyl or benzyl group which is non-substituted or substituted with Rc, or R3 and R4 form together a saturated, partially saturated, or unsaturated 5-, 6- or 7-membered heteromonocyclic ring or a saturated, partially saturated, or unsaturated 6-, 7-, 8-, 9-, 10- or 11-membered heterobicyclic ring compound which is mono-, di-, tri- or tetra-substituted with a nitrogen atom, an oxygen atom or a sulfur atom, or is non-substituted, Rc is selected from among a lower alkyl having 1 to 6 carbon atoms; a lower alkenyl having 2 to 4 carbon atoms; a lower alkoxy having 1 to 6 carbon atoms; a haloalkyl having 1 to 6 carbon atoms; a haloalkoxy having 1 to 6 carbon atoms or a halogen atom, Q1 is N or CR6, Q2 is N or CR7, Q3 is N or CR8, Q4 is N or CR9, Ar is selected from (Formula Removed) p is an integer of 0, 1, 2, 3 or 4, R6, R7, R8, and R9 may be the same or different, and are independently hydrogen; a lower alkyl having 1 to 8 carbon atoms; a lower alkenyl having 2 to 6 carbon atoms; a lower alkoxy having 1 to 8 carbon atoms; a haloalkyl having 1 to 6 carbon atoms; a haloalkoxy having 1 to 6 carbon atoms; a halogen atom; a nitro; hydroxy; hydroxymethyl; cyano; an amino which is mono- or di-substituted with a lower alkyl having 1 to 6 carbon atoms or is non-substituted; sulfanyl; sulfone; sulfoxide;urea; carbamate; carbonate; ketone; ester; cycloalkyl, pyridine, pyrimidine, pyrazole, phenyl, benzyl, imidazole, morpholine, benzodioxole, benzothiazole, benzoimidazole, indole, pyrazolone, thiophene, furan, thiazole, isothiazole, oxazole, isooxazole, triazole, oxodiazole, thiadiazole, indazole, thiomorpholine, thiazolidine, oxazolidine, pyrrolidine, chromonyl, piperidine, morpholinethyl, or dihydropyrazole group which is non-substituted or substituted with one or more Rd, or any two of R6, R7, R8, and R9 form together a saturated, partially saturated or unsaturated 5-, 6- or 7-membered heteromonocyclic or a saturated, partially saturated or unsaturated 6-, 7-, 8-, 9-, 10- or 11-membered heterobicyclic ring compound which is mono-, di-, tri- or tetra-substituted with a nitrogen atom, an oxygen atom or a sulfur atom or is non-substituted, Each Rd is independently selected from among a lower alkyl having 1 to 8 carbon atoms; a lower alkenyl having 2 to 6 carbon atoms; a lower alkoxy having 1 to 8 carbon atoms; a haloalkyl having 1 to 6 carbon atoms; a haloalkoxy having 1 to 6 carbon atoms; a halogen atom; a nitro; a hydroxyl; a cyano; an amino, amide, sulfanyl, sulfone, sulfoxide, sulfonamide, urea, carbamate, carbonate, ketone, ester, or carboxylic acid which is mono- or di-substituted with a lower alkyl having 1 to 6 carbon atoms or is non-substituted, R10, R11, and R12 may be the same or different, and are independently hydrogen; a lower alkyl having 1 to 8 carbon atoms; a cycloalkyl; a lower alkenyl having 2 to 6 carbon atoms; a lower alkoxy having 1 to 6 carbon atoms; a haloalkyl having 1 to 6 carbon atoms; a halogen atom; nitro; hydroxy; hydroxymethyl; cyano; sulfanyl; sulfone; sulfoxide; sulfonamide; urea; carbamate; carbonate; ketone; an amino, amide, carboxylic acid, or carboxyester group which is mono- or di-substituted with a lower alkyl having 1 to 3 carbon atoms or is non-substituted, or any two of R10, R11, and R12 form together a saturated or unsaturated heteromonocyclic or heterobicyclic ring compound. 2. The compound as claimed in claim 1, wherein the compound, the pharmaceutically acceptable salt thereof, or the isomers are selected from the group consisting of 2-[4-(3-chloropyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole, 6-chloro-2-[4-(3-chloropyridin-2-yl)phenyl]-1H-benzoimidazole, 6-tert-butyl-2-[4-(3-chloropyridin-2-yl)phenyl]-lH-benzoimidazole, 2-[4-(3-chloropyridin-2-yl)phenyl]-6-fluoro-lH-benzoimidazole, 2-[4-(3-chloropyridin-2-yl)phenyl]-6-methoxy-lH-benzoimidazole, 4-chloro-2-[4-(3-chloropyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole, 2-[4-(3-chloropyridin-2-yl)phenyl]-4,6-bistrifluoromethyl-lH-benzoimidazole, 2-[4-(3-chloropyridin-2-yl)phenyl]-6-trifluoromethyl-lH-imidazo[4,5-b]pyridine, 2-[4-(3-chloropyridin-2-yl)phenyl]-3H-imidazo[4,5- b]pyridine, 2-[4-(3-chloropyridin-2-yl)phenyl]-6,7-dimethyl-1H-benzoimidazole, 2-[4-(3-chloropyridin-2-yl)phenyl]-lH-benzoimidazole, 2-[4-(3-chloropyridin-2-yl)phenyl]-5, 6-dichloro-lH-benzoimidazole, 6-bromo-2-(4-(3-chloropyridin-2-yl)phenyl)-1H-benzoimidazole, 4-bromo-2-(4-(3-chloropyridin-2-yl)phenyl)-6-(trifluoromethyl)-lH-benzoimidazole, 6-bromo-2-(4-(3-chloropyridin-2-yl)phenyl-1H-imidazo[4,5-b]pyridine, 4,6-dibromo-2-[4-(3-chloropyridin-2-yl)phenyl]-lH-benzoimidazole, 2- [ 4-(3-chloropyridin-2-yl)phenyl]-6-morpholin-4-yl-lH-benzoimidazole, 2- [4- (3-chloropyridin-2-yl)phenyl]-6-thiomorpholin-4-yl-lH-benzoimidazole, 2-[4-(3-chloropyridin-2-yl)phenyl]-4-morpholin-4-yl-6-trifluoromethyl-lH-benzoimidazole, 2- [4- (3-chloropyridin-2-yl)phenyl]-4-thiomorpholin-4-yl-6-trifluoromethyl-lH-benzoimidazole, 2-[4-(3-chloropyridin-2-yl)phenyl]-4-pyrrolidin-l-yl-6-trifluoromethyl-lH-benzoimidazole, {2- [4- (3-chloropyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole-4-yl}diethylamine, 2-[4-(3-chloropyridin-2-yl)phenyl]-6-morpholin-4-yl-lH-imidazo[4,5-b]pyridine, 2-[4-(3-chloropyridin-2-yl)phenyl]-6-pyrrolidin-l-yl-lH-imidazo[4,5-b]pyridine, 6-tert-butyl-2-[4-(3,5-dichloropyridin-2-yl)phenyl]-1H-benzoimidazole, 2- [4- (3,5-dichloropyridin-2-yl)phenyl]-4,6- bistrifluoromethyl-lH-benzoimidazole, 6-tert-butyl-2-[4-(3-chloro-5-trifluoromethylpyridin-2-yl)phenyl] -lH-benzoimidazole, 2-[4-(3-chloro-5-trifluoromethylpyridin-2-yl}phenyl]-4,6-bistrifluoromethyl-lH-benzoimidazole, 2-[4-(3-chloro-5-trifluoromethylpyridin-2-yl)phenyl]-5,7-bistrifluoromethyl-lH-benzoimidazole, N-[4'-(4,6-bistrifluoromethyl-lH-benzoimidazole-2-yl)-3-fluorobiphenyl-4-yl]methanesulfonamide, 6-tert-butyl-2-[A-(3-trifluoromethylpyridin-2-yl)phenyl]-lH-benzoimidazole, 4-chloro-6-trifluoromethyl-2-[4-(3-trifluoromethylpyridin-2-yl)phenyl]-lH-benzoimidazole, 6-chloro-2-[4-(3-trifluoromethylpyridin-2-yl)phenyl]-lH-benzoimidazole, 4,6-bistrifluoromethyl-2-[4-(3-trifluoromethyl pyridin-2-yl)phenyl]-lH-benzoimidazole, 6-trifluoromethyl-2-[4-(3-trifluoromethylpyridin-2-yl)phenyl]-lH-imidazo[4,5-b]pyridine, 5,6-dichloro-2-[4-(3-trifluoromethylpyridin-2-yl)phenyl]-lH-benzoimidazole, 4-bromo-6-(trifluoromethyl)-2-(4-(3-(trifluoromethyl) pyridin-2-yl}phenyl)-lH-benzoimidazole, 6-bromo-2-(4-(3-{trifluoromethyl)pyridin-2-yl)phenyl}-lH-benzoimidazole, 6-fluoro-2-{4-(3-(trifluoromethyl)pyridin-2-yl)phenyl)-lH-benzoimidazole, 6-bromo-2-(4-(3-(trifluoromethyl)pyridin-2-yl)phenyl-lH-imidazo[4, 5-b]pyridine, 4,6-dibromo-2-[4-(3-trifluoromethylpyridin-2-yl)phenyl]-lH-benzoimidazole, 6-morpholin-4-yl-2-[4-(3-trifluoromethylpyridin-2-yl)phenyl]-lH-benzoimidazole, benzoimidazole, 2-(4-(6-(trifluoromethyl)-lH-benzoimidazole-2-yl)phenyl)pyridin-3-carbonitrile, 2-(4-(6-(tert-butyl-lH-benzoimidazole-2-yl)phenyl)pyridin-3-carbonitrile, 6'-(4,6-dibromo-lH-benzoimidazole-2-yl)-[2,3']bipyridyl-3-carbonitrile, 2-[4-(3-chloropyrazin-2-yl)phenyl]-6-trifluoromethyl-1H-benzoimidazole, 6-tert-butyl-2-[4-(3-chloropyrazin-2-yl)phenyl]-1H-benzoimidazole, 6-bromo-2-[4-(3-chloropyrazin-2-yl)phenyl]-1H-benzoimidazole, 5,6-dichloro-2-[4-(3-chloropyrazin-2-yl)phenyl]-1H-benzoimidazole, 6-bromo-2-[4-(3-chloropyrazin-2-yl)phenyl]-1H-imidazo[4 , 5-b]pyridine, 6-tert-butyl-2-[4-(3-chloropyridin-2-yl)-2-fluorophenyl]-lH-benzoimidazole, 4-chloro-2-[4-(3-chloropyridin-2-yl)-2-fluorophenyl]-6-trifluoromethyl-lH-benzoimidazole, 2-[4-(3-chloropyridin-2-yl)-2-fluorophenyl]-6-methoxy-lH-benzoimidazole, 6-tert-butyl-2-[4-(3,5-dichloropyridin-2-yl)-2-fluorophenyl]-lH-benzoimidazole, 4-chloro-2-[4-(3,5-dichloropyridin-2-yl)-2-fluorophenyl]-6-trifluoromethyl-lH-benzoimidazole, 2-[4-(3,5-dichloropyridin-2-yl)-2-fluorophenyl]-4,6-bistrifluoromethyl-lH-benzoimidazole, 4-chloro-2-[4- (3-chloro-5-trifluoromethylpyridin-2-yl)-2-fluorophenyl]-6-trifluoromethyl-lH-benzoimidazole, 2-[4-(3-chloro-5-trifluoromethylpyridin-2-yl)-2-fluorophenyl]-6-trifluoromethyl-lH-imidazo[4,5-b]pyridine, 2- [4- (3-chloro-5-trifluoromethylpyridin-2-yl)-2-fluorophenyl]-6-methoxy-lH-benzoimidazole, N-[3,3'-difluoro-4'-(6-methoxy-lH-benzoimidazole-2-yl)biphenyl-4-yl]methanesulfonamide, 2- [2-fluoro-4-(3-trifluoromethylpyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole, 6-tert-butyl-2-[2-fluoro-4-(3-trifluoromethylpyridin-2-yl)phenyl]-lH-benzoimidazole, 6-chloro-2-[2-fluoro-4-(3-trifluoromethylpyridin-2-yl)phenyl]-lH-benzoimidazole, 5-chloro-2-[2-fluoro-4-(3-trifluoromethylpyridin-2-yl)phenyl]-lH-benzoimidazole, 4-chloro-2-[2-fluoro-4-(3-trifluoromethylpyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole, 7-chloro-2-[2-fluoro-4-(3-trifluoromethylpyridin-2-yl)phenyl]-5-trifluoromethyl-lH-benzoimidazole, 2-(2-fluoro-4-pyridin-2-yl)phenyl-6-trifluoromethyl-lH-benzoimidazole, 6-tert-butyl-2-(2-fluoro-4-pyridin-2-yl)phenyl-1H-benzoimidazole, 6-chloro-2-(2-fluoro-4-pyridin-2-yl)phenyl-1H-benzoimidazole, 2-(2-fluoro-4-pyridin-2-yl)phenyl-4,6-bistrifluoro methyl-lH-benzoimidazole, 2-[2-chloro-4-(3-chloropyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole, 4-chloro-2-[2-chloro-4-(3-chloropyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole, 2-[2-chloro-4-(3-chloropyridin-2-yl)phenyl]-6-trifluoromethyl-lH-imidazo[4,5-b]pyridine, 2-[2-chloro-4-(3,5-dichloropyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole, 4-chloro-2-[2-chloro-4-(3,5-dichloropyridin-2- yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole, 2- [2-chloro-4-(3,5-dichloropyridin-2-yl)phenyl]-4, 6-bistrifluoromethyl-lH-benzoimidazole, 2- [2-chloro-4-(3,5-dichloropyridin-2-yl)phenyl]-6-trifluoromethyl-lH-imidazo[4,5-b]pyridine, 2-[2-chloro-4-(3-chloro-5-trifluoromethylpyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole, 4-chloro-2-[2-chloro-4-(3-chloro-5-trifluoromethylpyridin-2-yl)phenyl]-6-trifluoromethyl-1H-benzoimidazole, N-[4'-(6-tert-butyl-lH-benzoimidazole-2-yl)-3'-chloro-3-fluorobiphenyl-4-yl]methanesulfonamide, N-[3'-chloro-4'-(4-chloro-6-trifluoromethyl-1H-benzoimidazole-2-yl)-3-fluorobiphenyl-4-yl]methanesulfonamide, N- [4'- (4,6-bistrifluoromethyl-lH-benzoimidazole-2-yl)-3'-chloro-3-fluorobiphenyl-4-yl]methanesulfonamide, 2- [2-chloro-4-(3-trifluoromethylpyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole, 4-chloro-2-[2-chloro-4-(3-trifluoromethylpyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole, 2- [2-chloro-4-(3-trifluoromethylpyridin-2-yl)phenyl]-4,6-bistrifluoromethyl-lH-benzoimidazole, 6-tert-butyl-2-[2-chloro-4-(3-methylpyridin-2-yl)phenyl]-lH-benzoimidazole, 6-chloro-2-(2-chloro-4-pyridin-2-ylphenyl)-1H-benzoimidazole, 2-(2-chloro-4-pyridin-2-ylphenyl)-6-trifluoromethyl-lH-imidazo[4, 5-b]pyridine, 2- (2-chloro-4-pyridin-2-ylphenyl)-6-methoxy-lH-benzoimidazole, 2-[4-(3-chloropyridin-2-yl)naphthalen-1-yl]-6-trifluoromethyl-lH-benzoimidazole, 6-tert-butyl-2-[4-(3-chloropyridin-2-yl)naphthalen-1-yl]-lH-benzoimidazole, 2-[4-(3-chloropyridin-2-yl)naphthalen-1-yl]-4,6-bistrifluoromethyl-lH-benzoimidazole, 2- [4- (3-chloropyridin-2-yl)naphthalen-1-yl]-6-trifluoromethyl-lH-imidazo[4,5-b]pyridine, 6-tert-butyl-2-[4-(3,5-dichloropyridin-2-yl)naphthalen-1-yl]-lH-benzoimidazole, 2-[4-(3,5-dichloropyridin-2-yl)naphthalen-1-yl]-4,6-bistrifluoromethyl-lH-benzoimidazole, 6-tert-butyl-2-[4-(3-chloro-5-trifluoromethylpyridin-2-yl)naphthalen-1-yl]-lH-benzoimidazole, 2- [4- (3-chloro-5-trifluoromethylpyridin-2-yl)naphthalen-1-yl]-4,6-bistrifluoromethyl-lH-benzoimidazole, N-{4-[4- (4,6-bistrifluoromethyl-lH-benzoimidazole-2-yl)naphthalen-1-yl]-2-fluorophenyl}methanesulfonamide, 6-trifluoromethyl-2-[4-(3-trifluoromethylpyridin-2-yl)naphthalen-1-yl]-lH-benzoimidazole, 6-tert-butyl-2-(4-pyridin-2-ylnaphthalen-l-yl)-1H-benzoimidazole, 2- (4-pyridin-2-ylnaphthalen-l-yl)-4, 6-bistrifluoromethyl-lH-benzoimidazole, 6-tert-butyl-2-[3-chloro-4-(3-chloropyridin-2-yl)phenyl]-lH-benzoimidazole, 2-[3-chloro-4-(3,5-dichloropyridin-2-yl)phenyl]-6-trifluoromethy1-lH-benzoimidazole, 6-tert-butyl-2-[3-chloro-4-(3,5-dichloropyridin-2-yl)phenyl]-lH-benzoimidazole, 2-[3-chloro-4-(3,5-dichloropyridin-2-yl)phenyl]-6-methoxy-lH-benzoimidazole, 2-[3-chloro-4-(3,5-dichloropyridin-2-yl)phenyl]-5-methoxy-lH-benzoimidazole, 2- [3-chloro-4-(3-chloro-5-trifluoromethylpyridin-2- yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole, 6-tert-butyl-2-[3-chloro-4-(3-chloro-5-trifluoromethylpyridin-2-yl)phenyl]-lH-benzoimidazole, 2-[3-chloro-4-(3-chloro-5-trifluoromethylpyridin-2-yl)phenyl]-6-methoxy-lH-benzoimidazole, 2-[3-chloro-4-(3-chloro-5-trifluoromethylpyridin-2-yl)phenyl]-5-methoxy-lH-benzoimidazole, N-[2' -chloro-4' -(4-chloro-6-trifluoromethyl-lH-benzoimidazole-2-yl)-3-fluorobiphenyl-4-yl]methanesulfonamide, N- [4'- (4,6-bistrifluoromethyl-lH-benzoimidazole-2-yl)-2'-chloro-3-fluorobiphenyl-4-yl]methanesulfonamide, 2- (3-chloro-4-pyridin-2-ylphenyl)-6-trifluoromethyl-lH-benzoimidazole, 6-tert-butyl-2-(3-chloro-4-pyridin-2-ylphenyl)-1H-benzoimidazole, 6-chloro-2-(3-chloro-4-pyridin-2-ylphenyl)-1H-benzoimidazole, 4-chloro-2-(3-chloro-4-pyridin-2-ylphenyl)-6-trifluoromethyl-lH-benzoimidazole, 5,6-dichloro-2-(3-chloro-4-(pyridin-2-yl)phenyl)-1H-benzoimidazole, 6-bromo-2-(3-chloro-4-(pyridin-2-yl)phenyl)-1H-benzoimidazole, 2-[3-chloro-4-(3-trifluoromethylpyridin-2-yl)phenyl]-6-trifluoromethyl-lH-benzoimidazole, 6-tert-butyl-2-[3-chloro-4-(3-trifluoromethylpyridin-2-yl)phenyl]-lH-benzoimidazole, 6-chloro-2-[3-chloro-4-(3-trifluoromethylpyridin-2-yl)phenyl]-lH-benzoimidazole, 2- [3-chloro-4-(3-trifluoromethylpyridin-2-yl)phenyl]-6-methoxy-lH-benzoimidazole, 2-[3-chloro-4-(3-methylpyridin-2-yl)phenyl]-6- trifluoromethyl-lH-benzoimidazole, 3-chloro-6'-(6-trifluoromethyl-lH-benzoimidazole-2-yl)-[2,3'Jbipyridine, 3-chloro-6'-(6-chloro-lH-benzoimidazole-2-yl)-[2,3']bipyridine, 3-chloro-6'-(4-chloro-6-trifluoromethyl-lH-benzoimidazole-2-yl)-[2,3']bipyridine, 6'-(4,6-bistrifluoromethyl-lH-benzoimidazole-2-yl)-3-chloro-[2,3']bipyridine, 4-bromo-2-(5-(3-chloropyridin-2-yl)pyridin-2-yl)-6-(trifluoromethyl)-lH-benzoimidazole, 6-bromo-2-(5-(3-chloropyridin-2-yl)pyridin-2-yl)-1H-benzoimidazole, 6'-(6-tert-butyl-lH-benzoimidazole-2-yl)-3-chloro-[2,3']bipyridine, 3-chloro-6'-(5,6-dichloro-lH-benzoimidazole-2-yl)-[2,3'Jbipyridine, 3-chloro-6'-(4,6-dibromo-lH-benzoimidazole-2-yl)-[2,3']bipyridine, 6'-(6-bromo-lH-imidazo[4,5-b]pyridine-2-yl)-3-chloro-[2,3']bipyridine, 3-chloro-6'-(6-morpholin-4-yl-lH-benzoimidazole-2-yl)-[2,3']bipyridine, 3-chloro-6'-(6-thiomorpholin-4-yl-lH-benzoimidazole-2-yl)-[2,3'Jbipyridine, 3-chloro-6' -(4-morpholin-4-yl-6-trifluoromethyl-lH-benzoimidazole-2-yl)-[2,3']bipyridine, 3-chloro-6'-(4-thiomorpholin-4-yl-6-trifluoromethyl-lH-benzoimidazole-2-yl)-[2,3'Jbipyridine, 3-chloro-6'-(4-pyrrolidin-l-yl-6-trifluoromethyl-lH-benzoimidazole-2-yl)-[2,3'Jbipyridine, 3,5-dichloro-6'-(6-trifluoromethyl-lH-benzoimidazole-2-yl)-[2,3'Jbipyridine, 6'-(6-tert-butyl-lH-benzoimidazole-2-yl)-3,5-dichloro-[2,3']bipyridine, 3,5-dichloro-6'-(6-chloro-lH-benzoimidazole-2-yl)-[2,3']bipyridine, 3,5-dichloro-6'-(4-chloro-6-trifluoromethyl-lH-benzoimidazole-2-yl)-[2,3']bipyridine, 6'-(4,6-bistrifluoromethyl-lH-benzoimidazole-2-yl)-3,5-dichloro-[2,3']bipyridine, 6'-(4,6-bistrifluoromethyl-lH-benzoimidazole-2-yl)-3-chloro-5-trifluoromethyl-[2,3']bipyridine, 6' - (6-methoxy-lH-benzoimidazole-2-yl)-3-chloro-5-trifluoromethyl-[2,3']bipyridine, 3-trifluoromethyl-6'-(6-trifluoromethyl-1H-benzoimidazole-2-yl)-[2,3']bipyridine, 6' - (6-tert-butyl-lH-benzoimidazole-2-yl)-3-trifluoromethyl-[2,3']bipyridine, 6'-(6-chloro-lH-benzoimidazole-2-yl)-3-trifluoromethyl-[2,3']bipyridine, 6'- (4-chloro-6-trifluoromethyl-lH-benzoimidazole-2-yl)-3-trifluoromethyl-[2,3']bipyridine, 6'-(5-trifluoromethyl-7-chloro-lH-benzoimidazole-2-yl)-3-trifluoromethyl-[2,3']bipyridine, 6'-(4,6-bistrifluoromethyl-lH-benzoimidazole-2-yl)-3-trifluoromethyl-[2,3']bipyridine, 6'-(5,6-dichloro-lH-benzoimidazole-2-yl)-3-trifluoromethyl-[2,3']bipyridine, 4-bromo-6-(trifluoromethyl)-2-(5-(3-(trifluoromethyl)pyridin-2-yl)pyridin-2-yl)-1H-benzoimidazole, 6-bromo-2-(5-(3-(trifluoromethyl)pyridin-2-yl)pyridin-2-yl)-lH-benzoimidazole, 6-fluoro-2-(5-(3-(trifluoromethyl)pyridin-2-yl)pyridin-2-yl)-lH-benzoimidazole, 6'-(6-bromo-lH-imidazo[4,5-b]pyridine-2-yl)-3-trifluoromethyl[2,3']bipyridine, 6'-(4 , 6-dibromo-lH-benzoimidazole-2-yl)-3-trifluoromethyl-[2,3']bipyridine, 6'-(6-morpholin-4-yl-lH-benzoimidazo-2-yl)-3-trifluoromethyl-[2,3']bipyridine, 6'-(4-morpholin-4-yl-6-trifluoromethyl-lH-benzoimidazole-2-yl)-3-trifluoromethyl-[2,3']bipyridine, 6'- (6-chloro-lH-benzoimidazole-2-yl)-[2,3']bipyridine, 6'-(6-trifluoromethyl-lH-imidazo[4,5-b]pyridine-2-yl)-[2,3']bipyridine, 5,6-dichloro-2-(5-(pyridin-2-yl)pyridin-2-yl)-1H-benzoimidazole, 6-tert-butyl-2-(6-naphthalen-l-ylpyridin-3-yl)-1H-benzoimidazole, 2- ( 6-naphthalen-l-ylpyridin-3-yl)-4,6-bistrifluoromethyl-lH-benzoimidazole, 2- (6-naphthalen-l-ylpyridin-3-yl)-5,7-bistrifluoromethyl-lH-benzoimidazole, 6-(trifluoromethyl)-2-(6-(naphtha1en-1-yl)pyridin-3-yl)-lH-benzoimidazole, 6-chloro-2- ( 6- (naphtha 1 en-1-yl) pyridin-3-yl) -1 Pi-ben zoimidazole, 2-(4-pyrrol-l-ylphenyl]-6-trifluoromethyl-lH-benzoimidazole, 2- (4-pyrrol-l-ylphenyl)-3H-imidazo[4 , 5-b]pyridine, 6-chloro-2-(4-pyrrol-l-ylphenyl]-lH-benzoimidazole, 6-tert-butyl-2-(4-pyrrol-l-ylphenyl]-lH-benzoimidazole, 6-fluoro-2-(4-pyrrol-l-ylphenyl]-lH-benzoimidazole, 2-biphenyl-4-yl-6-trifluoromethyl-1H-benzoimidazole, 2-biphenyl-4-yl-3H-imidazo[4,5-b]pyridine, 2-biphenyl-4-yl-6-chloro-lH-benzoimidazole, 2-biphenyl-4-yl-6-tert-butyl-lH-benzoimidazole, 2-biphenyl-4-yl-6-fluoro-lH-benzoimidazole, 2-biphenyl-4-yl-6-methoxy-lH-benzoimidazole, 2- (4-phenoxyphenyl-6-trifluoromethyl)-1H- benzoimidazole, 2-(4-phenoxyphenyl)-3H-imidazo[4,5-b]pyridine, 6-chloro-2-(4-phenoxyphenyl)-lH-benzoimidazole, 6-tert-butyl-2-(4-phenoxyphenyl)-lH-benzoimidazole, 6-fluoro-2-(4-phenoxyphenyl)-lH-benzoimidazole, 6-methoxy-2-(4-phenoxyphenyl)-lH-benzoimidazole, 2-[3-(4-chloropyrazol-l-ylmethyl)phenyl]-6- trifluoromethyl-1H-benzoimidazole, 6-chloro-2-[3-(4-chloropyrazol-l-ylmethyl)phenyl]-lH-benzoimidazole, 6-tert-butyl-2-[3-(4-chloropyrazol-l-ylmethyl)phenyl]- IH-benzoimidazole, 2-[3-(4-chloropyrazol-l-ylmethyl)phenyl]-6-fluoro-lH- benzoimidazole, phenyl-[4-(6-trifluoromethyl-lH-benzoimidazole-2- yl)phenyl]methanone, [4-(6-tert-butyl-lH-benzoimidazole-2- yl)phenyl]phenylmethanone, 2-[4-(3-chloropyridin-2-yl)phenyl]-6-trifluoromethyl- lH-benzoimidazole chloride, 6-tert-buty1-2-[4-(3-chloropyridin-2-yl)phenyl]-1H- benzoimidazole chloride, 6-tert-butyl-2-[4-(3-chloropyridin-2-yl)naphthalen-1- yl]-lH-benzoimidazole chloride, 6'-(4,6-bistrifluoromethyl-lH-benzoimidazole-2-yl)-3- chloro[2,3']bipyridine chloride, 3-trifluoromethyl-6'-(6-trifluoromethyl-1H- benzoimidazole-2-yl)-[2,3']bipyridine chloride, 6-tert-butyl-2-[4-(3-chloropyridin-2-yl)phenyl]-1H- benzoimidazole sodium salt, 3-trifluoromethyl-6'-(6-trifluoromethyl-lH-benzoimidazole-2-yl)-[2,3']bipyridine sulfate, 3-trifluoromethyl-6'-(6-trifluoromethyl-lH-benzoimidazole-2-yl)-[2,3']bipyridine phosphate, 3-trifluoromethyl-6'-(6-trifluoromethyl-lH-benzoimidazole-2-yl)-[2,3']bipyridine methansulfonate, and 3-trifluoromethyl-6'-(6-trifluoromethyl-lH-benzoimidazole-2-yl)-[2,3']bipyridine benzenesulfonate. 3. The compound as claimed in claim 1 along with a pharmaceutically acceptable carrier, as and when used in preparing a pharmaceutical composition.

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6498-delnp-2007-correspondence-others.pdf

6498-delnp-2007-description (complete).pdf

6498-DELNP-2007-Form-1-(03-06-2011).pdf

6498-delnp-2007-form-1.pdf

6498-delnp-2007-form-18.pdf

6498-DELNP-2007-Form-2-(03-06-2011).pdf

6498-delnp-2007-form-2.pdf

6498-delnp-2007-form-26.pdf

6498-DELNP-2007-Form-3-(03-06-2011).pdf

6498-delnp-2007-form-3.pdf

6498-delnp-2007-form-5.pdf

6498-DELNP-2007-GPA-(03-06-2011).pdf

6498-delnp-2007-pct-101.pdf

6498-delnp-2007-pct-210.pdf

6498-delnp-2007-pct-237.pdf

6498-delnp-2007-pct-304.pdf

6498-delnp-2007-pct-306.pdf

6498-delnp-2007-pct-332.pdf

6498-delnp-2007-pct-401.pdf

6498-delnp-2007-pct-409.pdf

6498-delnp-2007-pct-416.pdf

6498-DELNP-2007-Petition-137-(03-06-2011).pdf

6498-DELNP-2007-Petition-137-(30-05-2011).pdf