| Title of Invention | "AN α-2A/α-1A SELECTIVE AGONIST, 1-(2,3-DIMETHYL-PHENYL)-ETHYL-1,3-DIHYDRO-IMIDAZOLE-2-THIONE COMPOUND" |
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| Abstract | An α-2A/α-lA selective agonist, l-(2,3-dimethyl-phenyl)-ethyl-l,3-dihydro-imidazole-2-thione compound represented by or a pharmaceutically acceptable salt, ester, amide, sterioisomer or racemic mixture thereof. |
| Full Text | This patent application claims benefit of priority under 35 USC § 119(e) to provisional patent application 60/502,562, filed September 12, 2003, which is hereby incorporated by reference herein. BACKGROUND OF THE INVENTION FIELD OF THE INVENTION The invention relates generally to molecular medicine and, more particularly, to α-2 adrenergic agonists that are highly selective for the α-2A adrenergic receptor as compared to the α-lA adrenergic receptor. BACKGROUND INFORMATION A variety of conditions can be mediated, at least in part, by the sympathetic nervous system including a variety of conditions associated with stress. Sympathetically-enhanced conditions include, without limitation, sensory hypersensitivity such as sensory hypersensitivity associated with fibromyalgia or headache such as migraine; gastrointestinal diseases such as irritable bowel syndrome and dyspepsia; dermatological conditions such as psoriasis,-cardiovascular disorders; tachycardias; disorders of peripheral vasoconstriction including Raynaud's Syndrome and scleroderma; panic attack; metabolic disorders such as type II diabetes, insulin-resistance and obesity; disorders of muscle contraction including disorders of skeletal muscle contraction, disorders of smooth muscle contraction, spasticity, and disorders of muscle contraction associated with tension-type headache; behavioral disorders such as, but not limited to, over-eating and drug dependence; and sexual dysfunction. WE CLAIM: 1. An α-2A/α-lA selective agonist, l-(2,3-dimethyl-phenyl)-ethyl-l,3-dihydro-imidazole-2- thione compound represented by (Formula Removed) or a pharmaceutically acceptable salt, ester, amide, sterioisomer or racemic mixture thereof. 2. The α-2A/α-lA selective agonist as claimed in claim 1, wherein said selective agonist has an α-lA efficacy less than that of brimonidine or a ratio of α-lA/α-2A potency greater than that of brimonidine. 3. A pharmaceutical composition, comprising a pharmaceutical carrier and an α-2A/α-lA selective agonist that comprises a compound represented by (Formula Removed) or a pharmaceutically acceptable salt, ester, amide, sterioisomer or racemic mixture thereof. |
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712-delnp-2006-Abstract-(04-08-2011).pdf
712-DELNP-2006-Abstract-(13-12-2011).pdf
712-delnp-2006-Claims-(04-08-2011).pdf
712-DELNP-2006-Claims-(13-12-2011).pdf
712-delnp-2006-Correspodence Others-(12-08-2011).pdf
712-delnp-2006-Correspondence Others-(04-08-2011).pdf
712-DELNP-2006-Correspondence Others-(13-12-2011).pdf
712-delnp-2006-correspondence-others-1.pdf
712-delnp-2006-correspondence-others.pdf
712-DELNP-2006-Description (Complete)-(13-12-2011).pdf
712-delnp-2006-Drawings-(04-08-2011).pdf
712-DELNP-2006-Form-1-(13-12-2011).pdf
712-DELNP-2006-Form-2-(13-12-2011).pdf
712-delnp-2006-Form-3-(04-08-2011).pdf
712-delnp-2006-Form-3-(12-08-2011).pdf
712-delnp-2006-GPA-(04-08-2011).pdf
712-delnp-2006-Petition-137-(04-08-2011).pdf
| Patent Number | 251234 | |||||||||||||||
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| Indian Patent Application Number | 712/DELNP/2006 | |||||||||||||||
| PG Journal Number | 10/2012 | |||||||||||||||
| Publication Date | 09-Mar-2012 | |||||||||||||||
| Grant Date | 02-Mar-2012 | |||||||||||||||
| Date of Filing | 13-Feb-2006 | |||||||||||||||
| Name of Patentee | ALLERGAN, INC. | |||||||||||||||
| Applicant Address | 2525 DUPONT DRIVE, T2-7H, IRVINE,CA 92612, U.S.A. | |||||||||||||||
Inventors:
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| PCT International Classification Number | A61K 31/4164 | |||||||||||||||
| PCT International Application Number | PCT/US2004/027134 | |||||||||||||||
| PCT International Filing date | 2004-08-20 | |||||||||||||||
PCT Conventions:
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