Indian Patents
Title of Invention

ALKIL-PYRIDINE COMPOUNDS
Abstract This invention is concerned with alkil-pyndine compounds of formula (I) as well as phannaceutically acceptable salts and esters thereof, wherein R1 to R6 have the significance given in claim 1 can be used in the form of pharmaceutical compositions.
Full Text The present invention is concerned with alkil-pyridine compounds useful as 11b-HSD1 inhibitors (T2D).
The invention is concerned particularly with compounds of formula (I)
(Formula Removed)
and pharmaceutically acceptable salts and esters thereof, wherein
R1 is hydrogen, alkyl, cycloalkyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl,
aminoalkyl, aryl, alkylsulfonyl, alkylsulfanyl, alkylcarbonylalkyl,
alkylcarbonyloxyalkyl, aminocarbonylalkyl, heterocyclylcarbonylalkyl,
heterocyclylalkoxyalkyl, alkoxycarbonylalkyl, alkoxyalkylaminocarbonylalkyl, cycloalkylalkoxyalkyl, arylalkyloxyalkyl, aryloxyalkyl, haloalkyl, haloalkoxy or haloalkoxyalkyl;
R2 is hydrogen, alkyl, cycloalkylalkoxyalkyl, alkoxyalkyl, arylalkoxyalkyl, haloalkoxyalkyl, piperidyl, pyrrolidyl, morpholinyl, thiomorpholinyl arylalkyl, arylalkoxy, aryloxy, heterocyclylalkoxy or heterocyclylalkyl;
R3 is hydrogen or alkyl;
R4 is hydrogen, alkyl or halogen;
R5 is phenyl, naphtyl, thiophenyl, pyridyl, quinolyl, piperidyl, morpholyl, thiomorpholyl or 1,2,3,4-tetrahydro-isoquinolinyl optionally substituted with one or more substituents independently selected from alkyl, cycloalkyl, halogen, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, hydroxyalkoxy, alkoxyalkoxy, cyano, nitro,
trifluoromethyl, trifluoromethoxy, trifluoromethylcarbonyl, aryl, arylalkyl, aryloxy, alkoxycarbonylalkoxy and alkylsulfonyl;
R6 is hydrogen or alkyl;
with the proviso that N-(6-(l,l-dimethylethyl)-2-pyridinyl)-4-methyl-benzenesulfonamide is excluded and in case R1 is hydrogen or methyl then R2 is not hydrogen or methyl.
Glucocorticoids (cortisol in humans, corticosterone in mice and rats) are an important class of adrenocorticosteroids that regulate many metabolic and homeostatic processes and form a key component of the response to stress. Glucocorticoids act via intracellular glucocorticoid receptors and, in some tissues, mineralocorticoid receptors; both being nuclear transcription factors. Glucocorticoid action on target tissues depends not only on circulating steroid concentrations and the cellular expression of receptors, but also on intracellular enzymes that critically determine to which extent glucocorticoids gain access to receptors in an active form. 1 Ibeta-hydroxysteroid dehydrogenases (1 Ibeta-HSD's) catalyze the interconversion of the principal active 11-hydroxy-glucocorticoid (Cortisol in men) and their inactive 11-keto metabolites (cortisone in men).
The enzyme 1 Ibeta-hydroxysteroid dehydrogenase type 1 (llbeta-HSDl) inter-converts inactive into active glucocorticoids, thereby playing a major role in local modulation of cellular agonist concentration and thus activation of corticosteroid receptors in target tissues, approximately two-fold up regulated in adipose tissue in obese individuals. Moreover, overexpressing llbeta-HSDl in adipocytes of mice led to visceral obesity and to a syndrome-X like phenotype (Masuzaki H. et al., Science. 2001 Dec 7; 294(5549):2166-70.). Taken together, these data very strongly support an important role of llbeta-HSDl in the induction of obesity and the impairment of glucose homeostasis and lipid parameters. Thus, selective inhibition of this enzyme could lower blood glucose levels in Type 2 diabetic patients, normalize elevated lipid parameters and/or reduce weight in obese subjects .

The first pharmacological indication that llbeta-HSDl inhibition in men might have beneficial effects were obtained by using carbenoxolone, an anti-ulcer drug which inhibits both llbeta-HSDl and the related enzyme llbeta-HSD2. Treatment with carbenoxolone led to an increase in insulin sensitivity indicating that that inhibition of llbeta-HSDl may reduce cellular cortisol levels and therefore minimizing some of its deleterious effects. (Walker et al. 1995; J. Clin. Endocrinol. Metab. 80, 31155-3159).
llbeta-HSDl is expressed in many tissues including liver, adipose tissue, vascular smooth muscles, pancreas and brain. Its activity is dependent on NADP(H) and it has a relatively low affinity for its substrate (compared to llbeta-HSD2). 11 beta-HSD1 in tissue homogenates and when purified is bidirectional, exhibiting both 1 Ibeta-dehydrogenase and 1 Ibeta-reductase reactions, with greater stability of the dehydrogenase activity (P.M. Stewart and Z.S. Krozowski, Vitam. Horm. 57 (1999), pp. 249-324). However, when the enzyme activity is tested in intact cells, the 1 Ibeta-reductase activity predominates, which regenerates active glucocorticoids from inert 11-keto forms. Such glucocorticoid regeneration will increase effective intracellular glucocorticoid levels and thereby amplifying glucocorticoid activity. It is this elevated cellular cortisol concentration that might lead to increased hepatic glucose production, adipocyte differentiation and insulin resistance.
Inhibition of llbeta-HSDl should not only reduce the typical Syndrome-X / Diabetes associated symptoms, but it should also be save and without major side effect. Studies with the unspecific inhibitor carbenoxolone highlight the importance of developing specific llbeta-HSDl inhibitors. The inhibition of the llbeta-HSD2 enzyme is badly tolerated and results in increased blood pressure. In contrast inhibition of llbeta-HSDl should be well tolerated since llbeta-HSDl knockout mice were found be healthy and to resist hyperglycemia provoked by obesity or stress (Kotelevtsev Y. et al., Proc Natl Acad Sci USA. 1997 Dec 23; 94(26): 14924-9). Similar upon starvation these mice had attenuated activation of key hepatic enzymes that are involved in gluconeogenesis. In addition, these mice had improved lipid and lipoprotein profiles suggesting that inhibition of HSD1 might be highly efficacious and safe. Recent reports indicate that llbeta-HSDl inhibitors might also be beneficial to reduce high blood pressure (Masuzaki H. et al., J Clin Invest. 2003 July;112(l):83-90; Rauz S. et al.,

QJM. 2003 July;96(7):481-90) to improve cognition (Sandeep TC. et al., Proc Natl Acad Sci USA. 2004 Apr. 27;101(17):6734-9) or to improve Alzheimer associated deficits. Taken together 11 beta-USD 1 inhibition might be a save and efficacious approach to treat symptoms of diabetes, obesity and other diseases.
The compounds of formula I and their pharmaceutically acceptable salts and esters are novel and have valuable pharmacological properties. In particular they are llb-HSDl inhibitors (T2D) and they display selectivity against the related llbeta-HSD2 enzyme. Therefore the compounds which are specific llbeta-HSDl inhibitors (T2D) represent an approach to e.g. lower blood glucose levels and normalize lipid parameters in Type 2 diabetic patients by modulating the local concentration of the active glucocorticoid cortisol in target tissue (liver, adipose tissue).
The compounds of the present invention can be used in the prophylaxis and/or treatment of metabolic disorders, obesity, dyslipidemiae, hypertension and/or diabetes, particularly diabetes Type II.
The compounds of this invention can further be used in the prophylaxis and/or treatment of high ocular eye pressure, cognition, Alzheimer and/or neurodegeneration.
Objects of the present invention are the compounds of formula I and their aforementioned salts and esters per se and their use as therapeutically active substances, a process for the manufacture of the said compounds, intermediates, pharmaceutical compositions, medicaments containing the said compounds, their pharmaceutically acceptable salts and esters, the use of the said compounds, esters and salts for the prophylaxis and/or therapy of illnesses, especially in the treatment or prophylaxis of eating disorders, obesity, dyslipidemiae, hypertension and/or diabetes, particularly diabetes Type II, and the use of the said compounds, salts and esters for the production of medicaments for the treatment or prophylaxis of metabolic disorders, obesity, dyslipidemiae, hypertension and/or diabetes, particularly diabetes Type II.
The compounds of the present invention can further be combined with PPAR (alpha, gamma, delta) agonists, DHEA (dehydroepiandrosterone), DPPIV inhibitors, insulin and/or lipase inhibitors, particularly orlistat.

In the present description the term "alkyl", alone or in combination, signifies a straight-chain or branched-chain alkyl group with 1 to 8 carbon atoms, preferably a straight or branched-chain alkyl group with 1 to 6 carbon atoms and particularly preferred a straight or branched-chain alkyl group with 1 to 4 carbon atoms Examples of straight-chain and branched alkyl groups are methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert.-butyl, the isomeric pentyls, the isomeric hexyls, the isomeric heptyls and the isomeric octyls, preferably methyl and ethyl and most preferred methyl.
The term "cycloalkyl", alone or in combination, signifies a cycloalkyl ring with 3 to 8 carbon atoms and preferably a cycloalkyl ring with 3 to 6 carbon atoms. Examples of Cs-Cg cycloalkyl are cyclopropyl, methyl-cyclopropyl, dimethylcyclopropyl, cyclobutyl, methyl-cyclobutyl, cyclopentyl, methyl-cyclopentyl, cyclohexyl, methyl-cyclohexyl, dimethyl-cyclohexyl, cycloheptyl and cyclooctyl, preferably cyclopropyl.
The term "alkoxy", alone or in combination, signifies a group of the formula alkyl-O- in which the term "alkyl" has the previously given significance, such as methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec. butoxy and tert.butoxy, preferably methoxy and ethoxy and most preferred methoxy.
The term "hydroxyalkyl", alone or in combination, signifies an alkyl group as defined before, wherein one or more hydrogen atoms, preferably one hydrogen atom is replaced by a hydroxy group. Examples of hydroxyalkyl are hydroxymethyl and hydroxyethyl.
The term "aryl", alone or in combination, signifies a phenyl or naphthyl group, preferably a phenyl group which optionally carries one or more substituents, preferably one to three, each independently selected from halogen, trifluoromethyl, trifluoromethoxy, amino, alkyl, alkoxy, alkylcarbonyl, cyano, carbamoyl, alkoxycarbamoyl, methylendioxy, carboxy, alkoxycarbonyl, aminocarbonyl, alkyaminocarbonyl, dialkylaminocarbonyl, hydroxy, nitro, alkyl-SCV, amino-SCV, cycloalkyl and the like. Preferred is phenyl or naphthyl, particularly phenyl optionally substituted with one to three, preferably one or two substituents independently selected

from alkyl, halogen, alkoxy, trifluoromethoxy, nitro and trifluoromethyl. Particularly preferred is phenyl.
The term "aryloxy", alone or in combination, signifies a aryl-O- group in which the term "aryl" has the previously given significance.
The term "heterocyclyl", alone or in combination signifies a saturated, partially unsaturated or aromatic 5- to 10-membered heterocycle which contains one or more hetero atoms selected from nitrogen, oxygen and sulphur. If desired, it can be substituted on one or more carbon atoms e.g. by halogen, alkyl, alkoxy, oxo etc. and/or on a secondary nitrogen atom (i.e. -NH-) by alkyl, cycloalkyl, aralkoxycarbonyl, alkanoyl, phenyl or phenylalkyl or on a tertiary nitrogen atom (i.e.=N-) by oxido, with halogen, alkyl, cycloalkyl and alkoxy being preferred. Examples of such heterocyclyl groups are pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, pyrazoyl, imidazoyl (e.g. imidazol-4-yl and 1-benzyloxycarbonyl- imidazol-4-yl), pyrazoyl, pyridyl, pyrazinyl, pyrimidinyl, hexahydro-pyrimidinyl, furyl, thienyl, thiazolyl, oxazolyl, indolyl (e.g. 2-indolyl), quinolyl (e.g. 2-quinolyl, 3-quinolyl and 1-oxido-2-quinolyl), isoquinolyl (e.g. 1-isoquinolyl and 3-isoquinolyl), tetrahydroquinolyl (e.g. 1,2,3,4-tetrahydro-2-quinolyl), 1,2,3,4-tetrahydroisoquinolyI (e.g. 1,2,3,4-tetrahydro-1-oxo-isoquinolyl) and quinoxalinyl. Preferred examples are thiophenyl, quinolyl, piperidyl, morpholyl, thiomorpholyl, oxazolyl, pyridinyl, pyrimidinyl, pyrazolyl, imidazolyl, pyrrolidinyl and thiazolyl. Particularly preferred examples are piperidyl, morpholyl, thiomorpholyl, pyridinyl and pyrrolidinyl.
The term "amino", alone or in combination, signifies a primary, secondary or tertiary amino group bonded via the nitrogen atom, with the secondary amino group carrying an alkyl or cycloalkyl substituent and the tertiary amino group carrying two similar or different alkyl or cycloalkyl substituents or the two nitrogen substitutents together forming a ring, such as, for example, -NHj, methylamino, ethylamino, dimethylamino, diethylamino, methyl-ethylamino, pyrrolidin-1-yl or piperidino etc., preferably primary amino, dimethylamino and diethylamino and particularly dimethylamino.
The term "halogen", alone or in combination, signifies fluorine, chlorine, bromine or iodine and preferably fluorine, chlorine or bromine.

The term "haloalkyl", alone or in combination, signifies an alkyl group as defined before, wherein one or more, preferably one to five hydrogen atoms are replaced by halogen, preferably fluoro. Examples of such haloalkyl groups are difluoromethyl, trifluoromethyl and pentafluoroethyl. Preferred is trifluoromethyl.
The term "haloalkoxy", alone or in combination, signifies an alkoxy group as defined before, wherein one or more, preferably one to five hydrogen atoms are replaced by halogen, preferably fluoro. Examples of such haloalkoxy groups are difluoromethoxy, trifluoromethoxy, monofluoroethoxy and pentafluoroethoxy. Preferred is trifluoromethoxy and monofluoroethoxy.
The term "hydroxyalkyl", alone or in combination, signifies an alkyl group as defined before, wherein one or more hydrogen atoms, preferably one hydrogen atom is replaced by a hydroxy group. Examples of hydroxyalkyl are hydroxymethyl and hydroxyethyl.
The term "carbonyl", alone or in combination, signifies the -C(O)- group. The term "oxy", alone or in combination, signifies the -O- group. The term "nitro", alone or in combination signifies the -NOz group. The term "cyano", alone or in combination signifies the group -CN.
The term "pharmaceutically acceptable salts" refers to those salts which retain the biological effectiveness and properties of the free bases or free acids, which are not biologically or otherwise undesirable. The salts are formed with inorganic acids such as hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid and the like, preferably hydrochloric acid, and organic acids such as acetic acid, propionic acid, glycolic acid, pyruvic acid, oxylic acid, maleic acid, malonic acid, succinic acid, ftimaric acid, tartaric acid, citric acid, benzoic acid, cinnamic acid, mandelic acid, methanesulfonic acid, ethanesulfonic acid, p-toluenesulfonic acid, salicylic acid, N-acetylcystein and the like. In addition these salts may be prepared form addition of an inorganic base or an organic base to the free acid. Salts derived from an inorganic base include, but are not limited to, the sodium, potassium, lithium, ammonium, calcium,

magnesium salts and the like. Salts derived from organic bases include, but are not limited to salts of primary, secondary, and tertiary amines, substituted amines including naturally occurring substituted amines, cyclic amines and basic ion exchange resins, such as isopropylamine, trimethylamine, diethylamine, triethylamine, tripropylamine, ethanolamine, lysine, arginine, N-ethylpiperidine, piperidine, polymine resins and the like. The compound of formula I can also be present in the form of zwitterions. Particularly preferred pharmaceutically acceptable salts of compounds of formula 1 are the hydrochloride salts.
The compounds of formula I can also be solvated, e.g. hydrated. The solvation can be effected in the course of the manufacturing process or can take place e.g. as a consequence of hygroscopic properties of an initially anhydrous compound of formula I (hydration). The term pharmaceutically acceptable salts also includes physiologically acceptable solvates.
"Pharmaceutically acceptable esters" means that compounds of general formula (I) may be derivatised at functional groups to provide derivatives which are capable of conversion back to the parent compounds in vivo. Examples of such compounds include physiologically acceptable and metabolically labile ester derivatives, such as methoxymethyl esters, methylthiomethyl esters and pivaloyloxymethyl esters. Additionally, any physiologically acceptable equivalents of the compounds of general formula (I), similar to the metabolically labile esters, which are capable of producing the parent compounds of general formula (I) in vivo, are within the scope of this invention.
The compounds of formula I can contain several asymmetric centers and can be present in the form of optically pure enantiomers, mixtures of enantiomers such as, for example, racemates, optically pure diastereioisomers, mixtures of diastereoisomers, diastereoisomeric racemates or mixtures of diastereoisomeric racemates.
Preferred are the compounds of formula I and pharmaceutically acceptable salts thereof, particularly the compounds of formula I.
Preferred are the compounds of formula I, wherein R5 is phenyl, naphtyl, thiophenyl, pyridyl, quinolyl, piperidyl, morpholyl, thiomorpholyl or 1,2,3,4-tetrahydro-

isoquinolinyl optionally substituted with one or more substituents, preferably one to three substituents, independently selected from alkyl, cycloalkyl, halogen, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, hydroxyalkoxy, alkoxyalkoxy, cyano, nitro, trifluoromethyl, trifluoromethoxy, trifluoromethylcarbonyl, aryl, arylalkyl, aryloxy, alkoxycarbonylalkoxy and alkyl-SO2-.
Particularly preferred are those compounds of formula I, wherein R5 is phenyl, naphtyl, thiophenyl, pyridyl, quinolyl, piperidyl, morpholyl, thiomorpholyl or 1,2,3,4-tetrahydro-isoquinolinyl optionally substituted with one or two substituents independently selected from alkyl, cycloalkyl, halogen, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, hydroxyalkoxy, alkoxyalkoxy, cyano, nitro, trifluoromethyl, trifluoromethoxy, trifluoromethylcarbonyl, aryl, arylalkyl, aryloxy, alkoxycarbonylalkoxy and alkyl-SO2-.
Further preferred are compounds according to formula I, wherein R5 is phenyl, naphtyl, piperidyl or 1,2,3,4-tetrahydro-isoquinolinyl optionally substituted with one to three substituents independently selected from alkyl, halogen, alkoxy, nitro, trifluoromethyl, trifluoromethoxy, trifluoromethylcarbonyl, aryl, aryloxy and alkyl-SCV
Particularly preferred are compounds of formula I, wherein R5 is phenyl or naphtyl optionally substituted with one to three substituents independently selected from alkyl, halogen, trifluoromethyl, trifluoromethoxy and aryl.
Also preferred are compounds according to formula I, wherein R6 is hydrogen.
Preferred are compounds of formula I, wherein R1 is hydrogen, alkyl, cycloalkyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, aminoalkyl, aryl, heterocyclyl, alkylsulfonyl, alkylsulfanyl, alkylcarbonylalkyl, alkylcarbonyloxyalkyl, aminocarbonylalkyl, heterocyclylcarbonylalkyl, heterocyclylalkoxyalkyl such as e.g. pyridylmethoxymethyl, alkoxycarbonylalkyl, alkoxyalkylaminocarbonylalkyl, cycloalkylalkoxyalkyl, arylalkyloxyalkyl, aryloxyalkyl, haloalkyl, haloalkoxy or haloalkoxyalkyl.

Further preferred are compounds of formula I, wherein R1 is alkyl, cycloalkyl, hydroxyalkyl, aikoxyalkyl, aryl, alkoxyalkylaminocarbonylalkyl, cycloalkylalkoxyalkyl, arylalkyloxyalkyl or trifiuoroalkoxyalkyl.
Another preferred embodiment of the present invention are compounds of formula I, wherein R1 is hydrogen.
Preferred are the compounds of formula I, wherein R2 is hydrogen, alkyl, cycloalkylalkoxyalkyl, aikoxyalkyl, arylalkoxyalkyl, haloalkoxyalkyl such as e.g. fluoro-ethoxymethyl or trifluoro-ethoxymethyl, piperidyl, pyrrol idyl, morpholinyl, thiomorpholinyl arylalkyl, arylalkoxy, aryloxy, heterocyclylalkoxy or heterocyclylalkyl;
Further preferred are compounds of formula I, wherein R2 is hydrogen, cycloalkylalkoxyalkyl, aikoxyalkyl, piperidyl, pyrrolidyl, morpholinyl, thiomorpholinyl, arylalkyl or aryloxy.
Also preferred are compounds according to formula I, wherein R3 is hydrogen.
Further preferred are compounds according to formula I, wherein R4 is hydrogen or halogen.
Particularly preferred are those compounds of formula I, wherein R4 is hydrogen.
Examples of preferred compounds of formula (I) are:
3-Chloro-N-(6-ethyl-pyridin-2-yl)-2-methyl-benzenesulfonamide; Biphenyl-4-sulfonic acid (6-ethyl-pyridin-2-yl)-amide; Biphenyl-4-sulfonic acid (6-propyl-pyridin-2-yl)-amide; 3-Chloro-2-methyl-N-(6-propyl-pyridin-2-yl)-benzenesulfonamide; Naphthalene-2-sulfonic acid (6-propyl-pyridin-2-yl)-amide; 3,4-Dichloro-N-(6-propyl-pyridin-2-yl)-benzenesulfonamide;

2,5-Difluoro-N-(6-propyl-pyridin-2-yl)-benzenesulfonamide;
2,4-Dichloro-6-methyl-N-(6-propyl-pyridin-2-yl)-benzenesulfonamide;
5-Chloro-naphthalene-2-sulfonicacid(6-propyl-pyridin-2-yl)-amide;
3,4-Dimethoxy-N-(6-propyl-pyridin-2-yl)-benzenesulfonamide;
4,5-Dichloro-2-fluoro-N-(6-propyl-pyridin-2-yl)-benzenesulfonamide;
2,4-Dichloro-5-methyl-N-(6-propyl-pyridin-2-yl)-benzenesulfonamide;
Piperidine-1-sulfonic acid (6-propyl-pyridin-2-yl)-amide;
3-Chloro-N-(6-isopropyl-pyridin-2-yl)-4-methyl-benzenesulfonamide;
2,5-Difluoro-N-(6-isopropyl-pyridin-2-yl)-benzenesulfonamide;
N-(6-Isopropyl-pyridin-2-yl)-4-(4-trifluoromethyl-phenoxy)-benzenesulfonamide;
2,4-Dichloro-N-(6-isopropyl-pyridin-2-yl)-5-methyl-benzenesulfonamide;
N-(6-Isopropyl-pyridin-2-yl)-4-methanesulfonyl-benzenesulfonamide;
N-(6-Isopropyl-pyridin-2-yl)-4-trifluoromethoxy-benzenesulfonamide;
2-(2,2,2-Trifluoro-acetyl)-1,2,3,4-tetrahydro-isoquinoline-7-sulfonic acid (6-isopropyl-pyridin-2-yl)-am ide;
N-(6-IsopropyI-pyridin-2-yl)-3-(4-trifluoromethyl-phenoxy)-benzenesulfonamide; Naphthalene-2-sulfonic acid (6-isopropyl-pyridin-2-yl)-amide; N-(6-Isopropyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide; N-[6-(2-Chloro-phenyl)-pyridin-2-yl]-5-fluoro-2-methyl-benzenesulfonamide; 3-Chloro-N-[6-(2-chloro-phenyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide; Biphenyl-4-sulfonic acid [6-(2-chloro-phenyl)-pyridin-2-yl]-amide; 3-Chloro-N-[6-(2,4-difluoro-phenyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide; 3-Chloro-N-[6-(3-fluoro-phenyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide;

3-Chloro-N-[6-(2,3-difluoro-phenyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide;
3-Chloro-N-[6-(2,5-dichloro-phenyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide;
N-[6-(2,5-Dichloro-phenyl)-pyridin-2-yl]-5-fluoro-2-methyl-benzenesulfonamide;
3-Chloro-N-[6-(3-chloro-phenyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide;
N-[6-(3-Chloro-phenyl)-pyridin-2-yl]-5-fluoro-2-methyl-benzenesulfonamide;
3-ChIoro-N-[6-(2-fluoro-phenyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide;
5-Fluoro-N-[6-(2-fluoro-phenyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide;
3-Chloro-2-methyl-N-[6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-benzenesulfonamide;
5-Fluoro-2-methyl-N-[6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-benzenesulfonamide;
N-[6-(2-Chloro-phenyl)-pyridin-2-yl]-2,5-difluoro-benzenesulfonamide;
N-[6-(2-Chloro-phenyl)-pyridin-2-yl]-2-trifluoromethyl-benzenesuIfonamide;
3-Chloro-N-[6-(2-methoxy-phenyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide;
3-Chloro-N-[6-(4-fluoro-2-methyl-phenyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide;
5-Fluoro-N-[6-(4-fluoro-2-methyl-phenyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide;
N-[2,3']BipyridinyI-6-yl-3-chloro-2-methyl-benzenesulfonamide;
2,5-Difluoro-N-[6-(4-fluoro-2-methyl-phenyl)-pyridin-2-yl]-benzenesulfonamide;
2,4-Dichloro-N-[6-(4-fluoro-2-methyl-phenyl)-pyridin-2-yl]-6-methyl-benzenesulfonamide;
3,4-Dichloro-N-[6-(4-fluoro-2-methyl-phenyl)-pyridin-2-yl]-benzenesulfonamide; 3-Chloro-N-(6-methoxy-pyridin-2-yl)-2-methyl-benzenesulfonamide; Biphenyl-4-sulfonic acid (6-methoxy-pyridin-2-yl)-amide; 5-Fluoro-N-(6-methoxy-pyridin-2-yl)-2-methyl-benzenesulfonamide; Naphthalene-2-sulfonic acid (6-methoxy-pyridin-2-yl)-amide;

3-Chloro-N-(6-ethoxy-pyridin-2-yl)-2-methyl-benzenesulfonamide; Biphenyl-4-sulfonic acid (6-ethoxy-pyridin-2-yl)-amide; Naphthalene-2-sulfonic acid (6-ethoxy-pyridin-2-yl)-amide; 3-Chloro-N-(6-ethylsuIfanyl-pyridin-2-yl)-2-methyl-benzenesulfonamide; Biphenyl-4-sulfonic acid (6-ethylsulfanyl-pyridin-2-yl)-amide; Naphthalene-2-sulfonic acid (6-ethylsuIfanyl-pyridin-2-yl)-amide; Naphthalene-2-sulfonic acid (6-ethanesulfonyl-pyridin-2-yl)-amide; 3-Chloro-2-methyl-N-[6-(2-oxo-pentyl)-pyridin-2-yl]-benzenesulfonamide; 2-[6-(Biphenyl-4-sulfonylamino)-pyridin-2-yl]-N,N-diethyl-acetamide; Biphenyl-4-sulfonic acid [6-(2-morpholin-4-yl-2-oxo-ethyl)-pyridin-2-yl]-amide; [6-(3-Chloro-2-methyl-benzenesulfonylamino)-pyridin-2-yl]-acetic acid methyl ester; [6-(5-Fluoro-2-methyI-benzenesulfonylamino)-pyridin-2-yl]-acetic acid methyl ester; N,N-Diethyl-2-[6-(4'-fluoro-biphenyI-4-sulfonylamino)-pyridin-2-yl]-acetamide;
4-Fluoro-biphenyl-4-sulfonic acid [6-(2-morpholin-4-yl-2-oxo-ethyl)-pyridin-2-yl]-amide;
2-[6-(4-Fluoro-biphenyl-4-sulfonylamino)-pyridin-2-yl]-N-(2-methoxy-ethyl)-acetamide;
2-[6-(3-Chloro-2-methyl-benzenesulfonylamino)-pyridin-2-yl]-N,N-diethyl-acetamide; 2-[6-(3,4-Dichloro-benzenesulfonylamino)-pyridin-2-yl]-N,N-diethyl-acetamide
2-[6-(3-Chloro-2-methyl-benzenesulfonylamino)-3-methyl-pyridin-2-yl]-N,N-diethyl-acetamide;
2-[6-(3,4-Dichloro-benzenesulfonylamino)-3-methyl-pyridin-2-yl]-N,N-diethyl-acetamide;
3-Chloro-N-(6-hydroxymethyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;

3-Chloro-N-(6-methoxymethyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;
2,5-Difluoro-N-(6-methoxymethyl-pyridin-2-yl)-benzenesulfonamide;
3-Chloro-N-(6-methoxymethyI-pyridin-2-yl)-4-methyl-benzenesulfonamide;
N-(6-Cyclopropylmethoxymethyl-pyridin-2-yl)-2,5-difluoro-benzenesulfonamide;
5-FIuoro-N-(6-methoxymethyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;
2,5-Difluoro-N-(6-hydroxymethyl-pyridin-2-yl)-benzenesulfonamide;
Acetic acid 6-(2,5-difluoro-benzenesulfonylamino)-pyridin-2-ylmethyl ester;
Naphthalene-2-sulfonic acid (6-hydroxymethyl-pyridin-2-yl)-amide;
3-ChIoro-N-(6-cyclopropylmethoxymethyl-pyridin-2-yl)-4-methyl-benzenesulfonamide;
N-(6-Cyclopropylmethoxymethyl-pyridin-2-yl)-5-fluoro-2-methyl-benzenesulfonamide;
3-Chloro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-4-methyl-benzenesu Ifonam ide;
3-Chloro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide;
2,5-Difluoro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-benzenesulfonamide;
5-Fluoro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide;
Piperidine-1 -sulfonic acid (6-methoxymethyl-pyridin-2-yl)-amide; Piperidine-1 -sulfonic acid (6-cyclopropylmethoxymethyl-pyridin-2-yl)-amide
3-ChIoro-4-methyl-N-[6-(4-trifluororaethyl-phenoxymethyl)-pyridin-2-yl]-benzenesulfonamide;
3-Chloro-2-methyl-N-[6-(4-trifluoromethyl-phenoxymethyl)-pyridin-2-yl]-benzenesulfonamide;

2,5-Difluoro-N-[6-(4-trifluoromethyl-phenoxyniethyl)-pyridin-2-yl]-benzenesulfonamide;
5-Fluoro-2-methyl-N-[6-(4-trifluoromethyl-phenoxymethyl)-pyridin-2-yI]-benzenesulfonamide;
3-Chloro-N-(6-cyclopropylmethoxymethyl-pyridin-2-yl)-2-methyl-benzenesu Ifonam ide;
3,4-Dichloro-N-(6-cyclopropylmethoxymethyl-pyridin-2-yl)-benzenesulfonamide;
4-Fluoro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-benzenesulfonamide;
N-[6-(4-Fluoro-benzyloxymethyl)-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide;
3-Chloro-N-(5-cyclopropylmethoxymethyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;
N-(5-Cyclopropyl-methoxymethyl-pyridin-2-yl)-2,5-difluoro-benzenesulfonamide
4-Chloro-N-(5-cyclopropylmethoxymethyI-pyridin-2-yl)-3-methyl-benzenesu 1 fonam ide;
N-(5-Cyclopropylmethoxymethyl-pyridin-2-yl)-5-fluoro-2-methyl-benzenesulfonamide; Piperidine-l-sulfonicacid(5-cyclopropyl-methoxymethyl-pyridin-2-yl)-amide;
3-Chloro-N-(5-cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;
N-(5-Cyclopropylmethoxymethyl-6-rnethyl-pyridin-2-yl)-2,5-difluoro-benzenesu I fonam ide;
N-(5-Cyclopropylmethoxymethy!-6-methyl-pyridin-2-yl)-5-fluoro-2-methyl-benzenesulfonamide;
N-(5-Methoxymethyl-6-methyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide; 3-Chloro-N-(5-methoxymethyl-6-methyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;
N-[5-(4-Fluoro-benzyloxymethyl)-6-methyl-pyridin-2-yl]-3-trifluoromethylbenzenesulfonamide;

3-ChIoro-N-[5-(4-fluoro-benzyloxymethyl)-6-methyl-pyridin-2-yl]-2-methylbenzenesulfonamide;
N-(5-Ethoxymethyl-6-methyl-pyridin-2-yl)-3-trifluoromethylbenzenesulfonamide;
3-Chloro-2-methyl-N-{6-[(methyl-propyl-amino)-methyl]-pyridin2-yl}-benzenesulfonamide;
5-Fluoro-2-methyl-N-{6-[(tnethyl-propyl-amino)-methyl]-pyridin-2-yl}-benzenesulfonamide;
3-Chloro-N-(5-ethoxymethyl-6-methyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;
3-Chloro-N-(6-cyclopropyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;
Naphthalene-1-sulfonic acid (6-cyclopropyl-pyridin-2-yl)-amide;
4-Chloro-N-(6-cyclopropyl-pyridin-2-yl)-2,5-dimethyl-benzenesulfonamide;
4-Chloro-N-(6-cyclopropyl-pyridin-2-yl)-3-methyl-benzenesulfonamide;
N-(6-CycIopropyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide;
2,4-Dichloro-N-(6-cyclopropyl-pyridin-2-yl)-5-methylbenzenesulfonamide;
Naphthalene-2-sulfonic acid (6-cyclopropyl-pyridin2-yl)-amide;
N-(5-Cyclopropylmethoxymethyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide;
N-(5-Ethoxymethyl-6-methyl-pyridin-2-yl)-3,5-bis-trifluoromethyl-benzenesulfonamide;
4-Chloro-N-(5-ethoxymethyl-6-methyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonarnide;
4-Chloro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-3-trifluoromethyl-benzenesu 1 fonam ide;
4-Chloro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-2,5-dimethyl-benzenesulfonamide;

3-Trifluoromethyl->J-[6-(4-trifluoromethyl-phenoxymethyl)-pyridin-2-yl]-benzenesulfonamide;
N-[5-(2-Fluoro-ethoxymethyl)-6-methyl-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide;
3-Chloro-N-(5-cyclopropyImethoxymethyl-pyridin-2-yl)-benzenesulfonamide;
2,4-Dichloro-N-(5-cyclopropylmethoxymethyl-pyridin-2-yl)-6-methyl-benzenesulfonamide;
N-(5-Cyclopropylmethoxymethyl-pyridin-2-yl)-4-fluoro-3-trifluoromethyl-benzenesulfonamide;
3-Chloro-N-(5-cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-benzenesulfonamide;
2,4-Dichloro-N-(5-cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-6-methyl-benzenesulfonamide;
N-(5-Cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide;
2,4-Difluoro-N-[6-(3-fluoro-benzyloxymethyl)-pyridin-2-yl]-benzenesulfonamide; 3-Chloro-N-[6-(3-fluoro-benzyloxymethyl)-pyridin-2-yl]-benzenesulfonamide;
2,4-Dichloro-N-[6-(3-fluoro-benzyloxymethyl)-pyridin-2-yl]-6-methyl-benzenesu I fonam ide;
2,4-Difluoro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-benzenesulfonamide; 3-Chloro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-benzenesulfonamide;
2,4-DichIoro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-6-methyl-benzenesu 1 fonam ide;
N-(5-Cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-4-fluoro-3-trifluoromethyl-benzenesulfonamide;
4-Fluoro-N-[6-(3-fluoro-benzyloxymethyl)-pyridin-2-yl]-3-trifluoromethyl-benzenesu 1 fonamide;

4-Fluoro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide;
N-[6-(4-Fluoro-benzyloxymethyl)-pyridin-2-yl]-3-trifluoromethoxy-benzenesu I fonam ide;
N-(6-Methoxymethyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide;
2,4-Dichloro-N-(6-methoxymethyl-p)ridin-2-yl)-6-methyl-benzenesulfonamide;
3-Chloro-N-(6-methoxymethyl-pyridin-2-yl)-benzenesulfonamide;
3-Trifluoromethyl-N-[6-(3,3,3-trifluoro-propoxymethyl)-pyridin-2-yl]-benzenesulfonamide;
2,4-Dichloro-6-methyl-N-[6-(3,3,3-trifluoro-propoxymethyl)-pyridin-2-yl]-benzenesulfonamide;
N-[6-(2,2,2-Trifluoro-ethoxymethyl)-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide;
2,4-Dichloro-6-methyl-N-[6-(2,2,2-trifluoro-ethoxymethyl)-pyridin-2-yl]-benzenesulfonamide;
3-Chloro-N-[6-(2-cyclopropyl-ethoxymethyl)-pyridin-2-yl]-benzenesulfonamide;
N-[6-(2-Cyclopropyl-ethoxymethyl)-pyridin'2-yl]-3-trifluoromethyl-benzenesulfonamide;
N-[6-(2-Cyclopropyl-ethoxymethyl)-pyridin-2-yl]-4-fluoro-3-trifluoromethyl-benzenesulfonamide;
2,4-Dichloro-N-[6-(2-cyclopropyl-ethoxymethyl)-pyridin-2-yl]-6-methyl-benzenesulfonamide;
2,4-Dichloro-5-methyl-N-[6-(2,2,2-trifluoro-ethoxymethyl)-pyridin-2-yl]-benzenesulfonamide;
2-Chloro-N-[6-(2,2,2-trifluoro-ethoxymethyl)-pyridin-2-yl]-5-trifluoromethyl-benzenesu 1 fonamide;

2,4-Dichloro-N-[6-(3-chloro-benzyloxymethyl)-pyridin-2-yl]-6-methyl-benzenesu 1 fonam ide;
N-[6-(3-Chloro-benzyloxymethyl)-pyridin-2-yI]-4-fluoro-3-trifluoromethyl-benzenesulfonamide;
N-[6-(4-Chloro-benzyloxymethyl)-pyridin-2-yl]-4-fluoro-3-trifluoromethyl-benzenesulfonamide;
2,4-Dichloro-N-[6-(4-chloro-benzyloxymethyl)-pyridin-2-yl]-6-methyl-benzenesu I fonam ide;
N-[5-(2,2,2-Trifluoro-ethoxymethyl)-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide;
2,4-Dichloro-5-methyl-N-[5-(2,2,2-trifluoro-ethoxymethyl)-pyridin-2-yl]-benzenesulfonamide;
benzenesulfonamide;
3-Chloro-2-methyl-N-(5-pyrrolidin-l-yl-pyridin-2-yl)-benzenesulfonamide;
3-Chloro-2-methyl-N-(5-morpholin-4-yl-pyridin-2-yl)-benzenesulfonamide;
N-(5-Benzyl-pyridin-2-yl)-3-chloro-2-methyl-benzenesulfonamide;
3-Chloro-2-methyl-N-(5-phenethyl-pyridin-2-yl)-benzenesulfonamide;
3-Chloro-2-methyl-N-(6-methyl-5-phenethyl-pyridin-2-yl)-benzenesuIfonamide;
3-Chloro-2-methyl-N-(5-thiomorphoIin-4-yl-pyridin-2-yl)-benzenesulfonamide;
2,4-Dichloro-N-{5-[2-(4-chloro-phenyl)-ethyl]-pyridin-2-yl}-6-methyl-benzenesu 1 fonam ide;
3-Chloro-N-{5-[2-(4-methoxy-phenyl)-ethyl]-pyridin-2-yl}-2-methyl-benzenesulfonamide;
3-Chloro-N-{5-[2-(3-fluoro-phenyl)-ethyl]-pyridin-2-yl}-2-methyl-benzenesulfonamide;

3-Chloro-2-methyl-N-{5-[2-(2-trifluoromethyl-phenyl)-ethyl]-pyridin-2-yl}-benzenesulfonamide
3-Chloro-N-{5-[2-(4-fluoro-phenyl)-ethyl]-pyridin-2-yl}-2-methyl-benzenesulfonamide;
3-Chloro-2-methyl-N-(5-phenoxy-pyridin-2-yl)-benzenesulfonamide;
3-Chloro-N-[5-(2-chloro-phenoxy)-pyridin-2-yl]-2-methyl-benzenesulfonamide;
3-Chloro-N-[5-(4-fluoro-phenoxy)-pyridin-2-yl]-2-methyl-benzenesulfonamide;
2,4-Dichloro-6~methyl-N-(5-phenoxy-pyridin-2-yl)-benzenesulfonamide;
2,4-Dichloro-N-[5-(2-chloro-phenoxy)-pyridin-2-yl]-6-methyl-benzenesulfonamide;
2,4-Dichloro-N-[5-(4-fluoro-phenoxy)-pyridin-2-yl]-6-methyl-benzenesulfonamide;
3-Chloro-2-methyl-N-[5-(2-quinolin-2-yl-ethyl)-pyridin-2-yl]-benzenesulfonamide;
2,4-Dichloro-6-methyl-N-[5-(2-quinolin-2-yl-ethyl)-pyridin-2-yl]-benzenesulfonamide; and
3-Chloro-2-methyl-N-[5-(2-pyridin-2-yl-ethyl)-pyridin-2-yl]-benzenesulfonamide.
Examples of particularly preferred compounds of formula (I) are:
3-Chloro-N-(6-ethyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;
Biphenyl-4-sulfonic acid (6-propyl-pyridin-2-yl)-amide;
3-Chloro-2-methyl-N-(6-propyl-pyridin-2-yl)-benzenesulfonamide;
2,4-Dichloro-6-methyl-N-(6-propyl-pyridin-2-yl)-benzenesulfonamide;
5-Chloro-naphthalene-2-sulfonicacid(6-propyl-pyridin-2-yl)-amide;
3-Chloro-N-(6-isopropyl-pyridin-2-yl)-4-methyl-benzenesulfonamide;
N-(6-Isopropyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide;

3-Chloro-2-methyl-N-[6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-benzenesulfonamide; 2,5-Difluoro-N-[6-(4-fluoro-2-methyl-phenyl)-pyridin-2-yl]-benzenesulfonamide;
2,4-Dichloro-N-[6-(4-fluoro-2-methyl-phenyl)-pyridin-2-yl]-6-methyl-benzenesulfonamide;
2-[6-(3-Chloro-2-methyl-benzenesulfonylamino)-pyridin-2-yl]-N,N-diethyl-acetamide;
3-Chloro-N-(6-hydroxymethyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;
3-Chloro-N-(6-methoxymethyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;
3-Chloro-N-(6-cyclopropylmethoxymethyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;
3,4-Dichloro-N-(6-cycIopropylmethoxymethyl-pyridin-2-yl)-benzenesulfonamide;
4-Fluoro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-benzenesulfonamide;
N-[6-(4-Fluoro-benzyloxymethyl)-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide;
3-Chloro-N-(5-cyclopropylmethoxymethyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;
3-Chloro-N-(5-cycIopropylmethoxymethyl-6-methyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;
3-Chloro-N-(5-methoxymethyl-6-methyl-pyridin-2-yl)-2-methyI-benzenesulfonamide;
N-(5-Ethoxymethyl-6-methyl-pyridin-2-yl)-3-trifluoromethylbenzenesulfonamide;
3-Chloro-N-(6-cyclopropyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;
Naphthalene-1-sulfonic acid (6-cyclopropyl-pyridin-2-yl)-amide;
4-Chloro-N-(6-cyclopropyl-pyridin-2-yl)-2,5-dimethyl-benzenesulfonamide;
N-(6-Cyclopropyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide;
N-(5-Cyclopropylmethoxymethyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide;

4-Chloro-N-(5-ethoxymethyl-6-methyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide;
2,4-Dichloro-N-(5-cyclopropylmethoxymethyl-pyridin-2-yl)-6-methyl-benzenesulfonamide;
N-(5-Cyclopropylmethoxymethyl-pyridin-2-yl)-4-fluoro-3-trifluoromethyl-benzenesulfonamide;
2,4-Dichloro-N-(5-cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-6-methyl-benzenesu ifonamide;
N-(5-Cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide;
2,4-Dichloro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-6-methyl-benzenesu Ifonam ide;
4-Fluoro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide;
N-[6-(4-Fluoro-benzyloxymethyl)-pyridin-2-yl]-3-trifluoromethoxy-benzenesulfonamide;
N-(6-Methoxymethyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide;
3-Trifluoromethyl-N-[6-(3,3,3-trifluoro-propoxymethyl)-pyridin-2-yl]-benzenesulfonamide;
2,4-Dichloro-6-methyl-N-[6-(3,3,3-trifluoro-propoxymethyl)-pyridin-2-yl]-benzenesulfonamide;
2,4-Dichloro-6-methyl-N-[6-(2,2,2-trifluoro-ethoxymethyl)-pyridin-2-yl]-benzenesulfonamide;
2,4-Dichloro-N-[6-(2-cyclopropyl-ethoxymethyl)-pyridin-2-yl]-6-methyl-benzenesulfonamide;
2,4-Dichloro-N-[6-(3-chloro-benzyloxymethyl)-pyridin-2-yl]-6-methyl-benzenesulfonamide;

N-[6-(4-Chloro-benzyloxymethyl)-pyridin-2-yl]-4-fluoro-3-trifluoromethyl-benzenesulfonamide;
2,4-Dichloro-N-[6-(4-chloro-benzyloxymethyl)-pyridin-2-yl]-6-methyl-benzenesulfonamide;
3-Chloro-2-methyl-N-(3,4,5,6-tetrahydro-2H-[l,3']bipyridinyl-6'-yl)-benzenesulfonamide;
3-Chloro-2-methyl-N-(5-pyrrolidin-l-yl-pyridin-2-yl)-benzenesulfonamide;
3-Chloro-2-methyl-N-(5-motpholin-4-yl-pyridin-2-yl)-benzenesulfonamide;
N-(5-Benzyl-pyridin-2-yl)-3-chloro-2-methyl-benzenesulfonamide;
3-Chloro-2-methyl-N-(6-methyl-5-phenethyl-pyridin-2-yl)-benzenesulfonamide;
3-Chloro-2-methyl-N-(5-thiomorphoIin-4-yl-pyridin-2-yl)-benzenesulfonamide;
2,4-Dichloro-N-{5-[2-(4-chloro-phenyl)-ethyl]-pyridin-2-yl}-6-methyl-benzenesulfonamide;
3-Chloro-N-{5-[2-(3-fluoro-phenyl)-ethyl]-pyridin-2-yl}-2-methyl-benzenesulfonamide;
3-Chloro-N-{5-[2-(4-fluoro-phenyl)-ethyl]-pyridin-2-yl}-2-methyl-benzenesu 1 fonam ide;
3-Chloro-2-methyl-N-(5-phenoxy-pyridin-2-yl)-benzenesulfonamide; 3-Chloro-N-[5-(2-chloro-phenoxy)-pyridin-2-yl]-2-methyl-benzenesulfonamide; 3-Chloro-N-[5-(4-fluoro-phenoxy)-pyridin-2-yl]-2-methyl-benzenesulfonamide; 2,4-Dichloro-6-methyl-N-(5-phenoxy-pyridin-2-yl)-benzenesulfonamide;
2,4-Dichloro-N-[5-(2-chloro-phenoxy)-pyridin-2-yl]-6-methyl-benzenesulfonamide; and
2,4-Dichloro-N-[5-(4-fluoro-phenoxy)-pyridin-2-yl]-6-methyl-benzenesulfonamide.

Processes for the manufacture of compounds of formula I are an object of the invention.
The preparation of compounds of formula I of the present invention may be carried out in sequential or convergent synthetic routes. Syntheses of the invention are shown in the following Schemes. The skills required for carrying out the reaction and purification of the resulting products are known to those persons skilled in the art. The substituents and indices used in the following description of the processes have the significance given above unless indicated to the contrary.
In general, compounds of type I are readily accessible by sulfonylation of appropriately substituted 2-amino-pyridines of formula II with sulfonyl chlorides under various conditions that are known to persons skilled in the art. Examples of such conditions are - as indicated in Scheme 1 below - e.g. pyridine at elevated temperatures or THF under reflux conditions in the presence of a base such as potassium carbonate, sodium carbonate, sodium hydride, triethyl amine or the like.
(Figure Removed)Optionally, compounds of formula la with R6 is H obtained in this way can be further substituted at the sulfonamide nitrogen by treatment with a base such as sodium hydride, cesium carbonate, potassium carbonate or the like in a solvent such as DMF or THF or similar followed by alkylation of the resulting anion with an alkyl halide such as methyl iodide, ethyl bromide, benzyl bromide or the like in order to introduce the desired R6 substituent.
Appropriately substituted 2-amino-pyridines of formula II are either commercially available, are known in the literature or can be made in analogy to literature procedures from known starting materials. General approaches that have been used for the
synthesis of various aminopyridines of general formula II in the course of this invention are outlined below.
2-Aminopyridines of formula lib with R1 is alkyl, cycloalkyl, aryl or heterocyclyl can be made according to scheme 2 from compounds of formula III via metal-catalysed (Pd or Ni) cross-coupling reaction with corresponding organometallic reagent such as heterocyclyl-, alkyl-, cycloalkyl or aryl-boron, -zink or -tin reagents using Suzuki-, Stille- or Negishi-type coupling reactions (for literature: Suzuki, Chem. Rev., 1995, 95, 2475; Stille, Angew. Chem. IEE, 1986, 25, 508; Negishi, Ace. Chem. Res., 1982, 15, 340). The corresponding organometallic reagents used are either commercially available, known in the literature or were prepared according to standard procedures known in the art. Compounds of formula lie with Rl= aminocarbonylmethyl can be prepared according to scheme 2 from compounds IV, selective lithiation with for example lithium diisopropylamide (LDA) in THF, addition of COa (dry ice) to give compounds of formula V. Subsequent coupling with appropriate amines in the presence of a coupling reagent such as benzotriazol-l-yloxytris(dimethylamino)phosphonium hexafluorophosphate (BOP) in acetonitrile gives compounds of formula VI, which are then de-protected with trifluoro-acetic acid in a solvent such as methylene chloride to give compounds of formula He.
Scheme 2
(Figure Removed) (Ra)(Rb)N- means amino as defined before
Compounds of formula lid with Rl= alkoxycarbonylmethyl can be prepared according to scheme 3 from protected 2-amino-6-methyl pyridines of formula VII by selective lithiation with for example with LDA, subsequent addition of COa followed by standard esterification reactions, for example with an alkohol as solvent in the presence of thionyl chloride or with an alcohol in a suitable solvent in the presence of acid, or by applying a coupling reagent as discussed above, under simultaneous removal of the trimethylsilyl protecting groups when acidic reaction conditions are applied, to give com pounds of formula lid.
Compounds of formula He with Rl is alkylcarbonylmethyl can be obtained from VII via lithiation with N-butyllithium (BuLi), subsequent reaction with an appropriate alkyl nitrile and an acidic work-up to yield He. Alternatively, compounds of formula Ilc-d can be prepared from compounds of formula VIII, obtained from Ib via lithiation with LDA and COz addition, by standard esterification or amide formation reactions known in the art. Next higher homologues of above described amines of formula II, such as aminocarbonyl ethyl as Rl and the like, can be prepared from intermediates described
in schemes 2,3 via homologation reactions known in the art , e.g. via Arndt-Eistert synthesis starting with compounds of formula V to give analogues with aminocarbonyl ethyl as Rl.
Scheme 3
(Figure Removed)Compounds of formula Ilf with Rl is alkoxymethyl, heterocyclylalkoxymethyl, cycloalkylalkoxyalkyl, arylalkoxymethyl, aryloymethyl, haloalkoxymethyl and the like can be prepared according to scheme 4 starting from compounds of formula IX. Accordingly, de-protonation of IX with NaH in THF and subsequent reaction with an alkyl, arylalkyl or heterocyclylalkyl halide and the like gives rise to compound of formula X. Upon hydrolysis with a base such as aqueous 3N NaOH at elevated temperature compounds of formula Ilf are obained. The aryloxymethyl analogues are prepared from X via Mitsunobu reaction. Alternatively, intermediates of formula X can be obtained from XI via reaction with an appropriate alcohol ROH in the presence of a base such as NaH and in THF as solvent. Compounds of formula XI are obtained form IX via reaction with thionyl chloride. Compounds of formula Hg with Rl= aminomethyl and the like can be prepared from XI upon reaction with an appropriate amine in acetone as solvent, in the presence of KHCOs as base and with catalytic amounts of potassium iodide, to give XII that can subsequently be deprotected to give

Hg. Intermeditates of scheme 4 can also be converted to the next higher homologues as mentioned above and as known to persons skilled in the art.


(Figure Removed)Compounds of formula Ilh with R2 is cycloalkyloxymethyl, alkoxymethyl, arylalkoxymethyl, haloalkoxymethyl can be prepared according to scheme 5 from compounds of formula XIII via halogen lithium exchange with BuLi, reaction with DMF to give XIV, followed by NaBH4 reduction to yield XV. Functionalization reactions are then carried out in analogy to the reaction sequences discussed above, either via reacting XV with appropriate alkyl halogenids in the presence of NaH to give compounds of formula XVI, or from XVII via reaction with ROH and with NaH. XVII can be obtained from XV via treatment with thionyl chloride. Again, all intermediates can be used as already discussed above to make the next higher homologues.
Scheme 5(Figure Removed)
2-Aminopyridines of type Hi in which R2 is represented by a nucleophile Nu that is defined as outlined in Scheme 6 - e.g. a phenol or an amine - can be made in the following way: An appropriately substituted 5-halo-2-nitropyridine of formula XVIII is treated with an appropriate nuclephile - e.g. a phenol or an amine or the like - in the presence of a base such as sodium hydride, potassium carbonate or the like in a suitable solvent such as DMF, DMSO, THF or similar at temperatures ranging from 0 °C to 200 °C to give nitropyridine XIX. The nitro group present in compound XIX can be reduced using standard reduction conditions such as catalytic hydrogenation in the presence of a suitable catalyst such as Pd, Pt or the like or alternative conditions such as Sn(II)Cl2 in the presence of an acid such as HC1, HBr or the like to give the desired 2-aminopyridines Hi that can be treated in subsequent reaction steps as outlined in Scheme 1 to give sulfonamides of formula la and/or I.
Scheme 6:
(Figure Removed)2-Aminopyridines of type Hj in which R2 is represented by a (hetero)aryl-ethyl side chain as shown in Scheme 7 are made in the following way: An appropriately substituted 2-amino-5-halo-pyridine of formula XX is subjected to a Heck-type reaction in the presence of an appropriately substituted styrene or vinyl-(hetero)aromate under conditions that are known in the literature (see e.g. Heck et al., J. Am. Chem. Soc. 1968, 90, 5518) to furnish intermediate XXI. The double bond that is present in this material can optionally be reduced using conditions such as catalytic hydrogenation with various catalysts such as Pd, Pt or the like to give the desired 2-aminopyridines IIj that can be used in subsequent reaction steps as outlined in Scheme 1 to give compounds of formula la and/or I.
Scheme 7:
(Figure Removed)Preferred is the process for the preparation of a compound according to formula comprising
a) reaction of a compound according to formula(Figure Removed)in the presence of a compound according to formula
in order to obtain a compound of the formula
(Figure Removed)and optionally
b) further reaction in the presence of a compound of the formula R6-X in order to obtain a compound of the formula
(Figure Removed)wherein R1 to R6 are defined as before and X is Cl, Br or I. Particularly preferred is the above reaction a) in the presence of pyridine or THF and particularly in the presence of a base such as e.g. potassium carbonate, sodium carbonate, sodium hydride or triethyl amine. Particularly preferred is the above reaction b) in the presence of sodium hydride, cesium carbonate, potassium carbonate particularly in DMF or THF. Preferred examples of compounds according to formula R6-X are methyl iodide and ethyl bromide.
Preferred intermediates are:
6-IsopropyI-pyridin-2-ylamine;
6-(2-Chloro-pheny!)-pyridin-2-ylamine;
6-(2,4-Difluoro-phenyl)-pyridin-2-ylamine;
6-(3-Fluoro-phenyl)-pyridin-2-ylamine;
6-(2,3-Ditluoro-phenyl)-pyridin-2-ylamine;
6-(2,5-Dichloro-phenyl)-pyridin-2-ylamine;
6-(3-Chloro-phenyl)-pyridin-2-ylamine;
6-(2-Fluoro-phenyl)-pyridin-2-ylamine;
6-(2-Trifluoromethyl-phenyl)-pyridin-2-ylamine;
6-(2-Methoxy-phenyl)-pyridin-2-ylamine;
6-(4-Fluoro-2-methyl-phenyl)-pyridin-2-ylamine;
[2,3 ']Bipyridinyl-6-ylamine;
6-Ethylsulfanyl-pyridin-2-ylamine;
l-(6-Amino-pyridin-2-yl)-pentan-2-one;
(6-Amino-pyridin-2-yl)-acetic acid methyl ester;
2-(6-Amino-pyridin-2-yl)-N,N-diethyl-acetamide;
2-(6-Amino-3-methyl-pyridin-2-yl)-N,N-diethyl-acetamide;
6-Cyclopropylmethoxymethyl-pyridin-2-ylamine;
6-(4-Fluoro-benzyloxymethyl)-pyridin-2-ylamine;
6-(4-Trifluoromethyl-phenoxymethyl)-pyridin-2-ylamine;
5-Cyclopropylmethoxymethyl-pyridin-2-ylamine;
5-Cyclopropylmethoxyrnethyl-6-methyl-pyridin-2-yIamine;
5-Methoxymethyl-6-methyl-pyridin-2-ylamine;
5-(4-Fluoro-benzyloxymethyl)-6-methyl-pyridin-2-ylamine;
5-Ethoxymethyl-6-methyl-pyridin"2-ylamine;
6-[(MethyI-propyl-amino)-methyl]-pyridin-2-ylamine;
6-Cyclopropyl-pyridin-2-ylamine;
5-(2-Fluoro-ethoxymethyl)-6-methyl-pyridin-2-ylamine;
6-(3-Fiuoro-benzyloxymethyl)-pyridin-2-ylamine;
6-(3,3,3-Trifluoro-propoxymethyl)-pyridin-2-ylamine;
6-(2,2,2-TYifluoro-ethoxymethyl)-pyridin-2-ylamine;
6-(2-Cyclopropyl-ethoxymethyl)-pyridin-2-ylamine;
6-(3-Chloro-benzyloxymethyl)-pyridin-2-ylamine;
6-(4-Chloro-benzyloxymethyl)-pyridin-2-ylamine;
5-(2,2,2-Trifluoro-ethoxymethyl)-pyridin-2-ylamine;
3,4,5,6-Tetrahydro-2H-[l,3']bipyridinyl-6'-ylamine;
6-Methyl-5-phenethyl-pyridin-2-ylamine and
5-Phenoxy-pyridin-2-ylamine.
The compounds of formula I described above for use as therapeutically active substance are a further object of the invention.
Also an object of the present invention are compounds as decribed above for the preparation of medicaments for the prophylaxis and therapy of illnesses which are caused by disorders associated with the enzyme llbeta-hydroxysteroid dehydrogenasel (llbHSDl).
Likewise an object of the invention are pharmaceutical compositions comprising a compound of the formula I as described above and a therapeutically inert carrier.
A further preferred embodiment of the present invention is the use of a compound of the formula I as described above for the preparation of medicaments for the treatment and prophylaxis of diabetes, obesity, eating disorders, dyslipidemiae and hypertension.
Particularly preferred is the use of a compound according to formula I as described above for the preparation of medicaments for the treatment and prophylaxis of diabetes Type II.
A further object of the present invention comprises a compound according to formula I as described above, when manufactured according to any one of the described processes.
Also an object of the invention is a method for the treatment and prophylaxis of diabetes, obesity, eating disorders, dyslipidemiae and hypertension, which method comprises administering an effective amount of a compound of formula I as described above.
Particularly preferred is a method for the treatment and prophylaxis of diabetes Type II, which method comprises administering an effective amount of a compound according to formula I as described above.
Assay Procedures
Transient expression and partial Purification:
The cDNA encoding the human llbeta-HSDl protein was cloned into the expression vector pcDNA3 (Stratagene). This construct (for details see Alex Odermatt et al.; J Biol Chem.,1999, Vol. 274, Issue 40, 28762-28770) was used to transiently express the protein in HEK293 cells (ATCC number: CRL-1573, described in Graham, F.L., Smiley, J., Russell, W.C., Nairn, R.; (1977)) using lipofectamine. 48h after transfection cells were washed twice with ice-cold PBS (Phsophate buffered Saline). To 1 volume of cell suspension in PBS 2 volumes of ice-cold lysis buffer (50mM Tris; pH7.5; ImM EDTA; lOOmM NaCl) were added. The cells were lysed by Potter-homogenization (20 strokes). The resulting homogenate was sonicated wit a tip sonicator (10% output; 2 x 30 sec.) and cleared by a low speed centrifugation (lOmin x 9000g; 4°C). The microsomal fraction was collected by a high speed centrifugation (60 min x 110'OOOg). The resulting pellet was resuspended in storage buffer (20mM Tris pH 7.5; 1 mM

EDTA; 10% Glycerol) and the centrifugation was repeated. The resulting pellet containing the microsomal fraction was again taken up into storage buffer and aliquots were kept frozen in liquid Nitrogen until use.
Generation of stable cell lines expressing 1 Ibeta-HSDl:
The same construct used for transient expression of human 1 Ibeta-HSDl was also used to establish cell lines stably expressing the protein. Briefly, (HEK293) cells were transfected with 1 Ibeta-HSDl construct using the lipofectamine reagent (Gibco BRL) according to the manufacturer's instruction. Two days after transfection, geneticin selection (0.8 mg/ml) was initiated and several stable clones were isolated. One clone was further used for pharmacological characterization.
Microsome Assay
Microsomes isolated from HEK293 cells transiently expressing human 1 Ibeta-HSDl (for details see above) were incubated in assay buffer (100 mM NaCl; ItnM EDTA; I mM EGTA; ImM MgCl; 250 mM Sucrose; 20 mM Tris pH 7.4; Cortisone 50-200nM and NADPH ImM) together with different concentrations of test substances. After 60 min. of incubation at 37°C the assay was stopped by heating to 80°C (5 min.) and by addition of the inhibitor Carbenoxolone (1 uM). The amount of Cortisol produced in this assay was determined using a commercially available, ELISA-based Cortisol-detection kit (Distributed by Assay Design, Inc.). Inhibitors were characterized by there IC50 values, e.g. the concentration at which the production of cortisol was 50% reduced.
In this test preferred compounds as described above have IC50 values below 1000 nM; more preferred compounds have IC50 values below 100 nM. Most preferred compounds have IC50 values below lOnM.

Cellular Assay
To measure the effect of inhibitors in intact cells HEK293 cells stably expressing human llbeta-HSDl (see above) were cultivated in 96 well plates in DMEM. First inhibitors and 60 min later Cortisone was added to the cells. After 60 min of incubation at 37°C in a 5% CO2 atmosphere part of the medium was removed and the conversion from Cortisone to Cortisol was measured using a commercially available ELISA kit (Distributed by Assay Design, Inc.).
Results obtained in the microsome assay using representative compounds of the invention as the test compounds are shown in the following table:
(Table Removed)Compounds as described above have ICso values below 1000 nM; preferred compounds have ICso values below 100 nM. More preferred compounds have ICso values below 10 nM. These results have been obtained by using the foregoing test.
The compounds of formula I and their pharmaceutically acceptable salts and esters can be used as medicaments (e.g. in the form of pharmaceutical preparations). The pharmaceutical preparations can be administered internally, such as orally (e.g. in the form of tablets, coated tablets, , hard and soft gelatin capsules, solutions, emulsions or suspensions), nasally (e.g. in the form of nasal sprays) or rectally (e.g. in
the form of suppositories). However, the administration can also be effected parentally, such as intramuscularly or intravenously (e.g. in the form of injection solutions).
The compounds of formula I and their pharmaceutically acceptable salts and esters can be processed with pharmaceutically inert, inorganic or organic adjuvants for the production of tablets, coated tablets, drage"es and hard gelatin capsules. Lactose, corn starch or derivatives thereof, talc, stearic acid or its salts etc. can be used, for example, as such adjuvants for tablets, drage"es and hard gelatin capsules.
Suitable adjuvants for soft gelatin capsules, are, for example, vegetable oils, waxes, fats, semi-solid substances and liquid polyols, etc.
Suitable adjuvants for the production of solutions and syrups are, for example, water, polyols, saccharose, invert sugar, glucose, etc.
Suitable adjuvants for injection solutions are, for example, water, alcohols, polyols, glycerol, vegetable oils, etc.
Suitable adjuvants for suppositories are, for example, natural or hardened oils, waxes, fats, semi-solid or liquid polyols, etc.
Moreover, the pharmaceutical preparations can contain preservatives, solubilizers, viscosity-increasing substances, stabilizers, wetting agents, emulsifiers, sweeteners, colorants, flavorants, salts for varying the osmotic pressure, buffers, masking agents or antioxidants. They can also contain still other therapeutically valuable substances.
In accordance with the invention the compounds of formula I and their pharmaceutically acceptable salts can be used for the prophylaxis and treatment of arthritis, cardiovascular diseases, diabetes, renal failure and particularly eating disorders and obesity. The dosage can vary in wide limits and will, of course, be fitted to the individual requirements in each particular case. In general, in the case of oral administration a daily dosage of about 0.1 mg to 20 mg per kg body weight, preferably about 0.5 mg to 4 mg per kg body weight (e.g. about 300 mg per person), divided into preferably 1-3 individual doses, which can consist, for example, of the same amounts,
should be appropriate. It will, however, be clear that the upper limit given above can be exceeded when this is shown to be indicated.
The invention is illustrated hereinafter by Examples, which have no limiting character. Examples 1 to 5, 8, 11 to 14, 16 and 17 are included for preparation purpose and are not covered by claim 1.
Examples
Example 1: NaphthaIene-2-sulfonic acid (6-methyl-pyridin-2-yl)-amide
6-Methyl-pyridin-2-y!amine (1 g) and 2-naphthalenesulfonyl chloride (2.3 g) were dissolved in pyridine (5 mL) and the resulting mixture was allowed to stir at RT for 12 hours. After concentration in vacuo the residue was taken up in EtOAc, the solution washed withl N aqueous HC1, saturated brine then dried over sodium sulphate and concentrated in vacuo. The residue was purified by flash chromatography (heptane/EtOAc 5:1) to give the desired product naphthalene-2-sulfonic acid (6-methyl-pyridin-2-yl)-amide as a white foam (2.18 g). MS (ESF): 297.2 ([M-H]").
Example 2: N-(6-Methyl-pyridin-2-yl)-4-nitro-benzenesulfonamide
This material was obtained in analogy to example 1 from from 6-methyl-pyridin-2-ylamine with 4-nitro-benzenesulfonyl chloride as a yellow solid. MS (ESF): 292.0 ([M-H]-).
Example 3: N-[4-(6-Methyl-pyridin-2-yIsulfamoyl)-phenyl]-acetamide
This material was obtained in analogy to example 1 from 6-methyl-pyridin-2-ylamine and 4-acetamido-benzenesulfonyl chloride as a white solid. MS (ESI"): 304.0 ([M-H]").
Example 4: 3-Chloro-2-methyl-N-(6-methyl-pyridin-2-yl) benzenesulfonamide
This material was obtained in analogy to example 1 from 6-methyl-pyridin-2-ylamine (0.108 g) and 3-chloro-2methyl-benzenesulfonyl chloride (0.259 g) as an off-white crystalline solid (0.24 g). MS (ESF): 295.1 ([M-H]').
Example 5: Biphenyl-4-sulfonic acid (6-methyl-pyridin-2-yl)-amide
This material was obtained in analogy to example 1 from 6-methyl-pyridin-2-ylamine (0.108g) and biphenyl-4-sulfonyl chloride (0.278 g) as an off-white crystalline solid (0.157g). MS (ESO: 323.2 ([M-H]-).
Example 6: 3-Chloro-N-(6-ethyl-pyridin-2-yl)-2-methyl-benzenesulfonamide
This material was obtained in analogy to example 1 from 6-ethyl-pyridin-2-ylamine (0.25 g) and 3-chloro-2-methyl-benzenesulfonyl chloride (0.5 g) as a white solid (0.13 g). MS (ESO: 309.1 ([M-HD-
Example 7: Biphenyl-4-sulfonic acid (6-ethyl-pyridin-2-yl)-amide
This material was obtained in analogy to example 1 from 6-ethyl-pyridin-2-ylamine (0.25 g) and biphenyl-4-sulfonyl chloride chloride (0.57 g) as a white foam (0.156 g). MS (ESF): 337.1 ([M-HD
ExampleS: 5-Fluoro-2-methyl-N-(6-methyl-pyridin-2-yl)-benzenesulfonamide
This material was obtained in analogy to example 1 from 6-methyl-pyridin-2-ylamine (0.2 g) and biphenyl-4-sulfonyl chloride (0.42 g) as a yellow solid (0.132 g). MS (ESF): 278.9 ([M-H]-).
Example 9: Biphenyl-4-sulfonic acid (6-propyl-pyridin-2-yl)-amide
This material was obtained in analogy to example 1 from 6-propyl-pyridin-2-ylamine (0.2 g) and biphenyl-4-sulfonyl chloride (0.408 g) as an off-white solid (0.132 g). MS (ESr):351.2([M-H]').
Example 10: 3-Chloro-2-methyl-N-(6-propyl-pyridin-2-yl)-benzenesulfonamide
This material was obtained in analogy to example 1 from 6-propyl-pyridin-2-ylamine (0.2 g) and 3-chloro-2methyl-benzenesulfonyl chloride (0.386 g) as a white solid (0.34 g). MS (ESF): 323.2 ([M-H]").
Example 11: 3-Chloro-N-(4,6-dimethyl-pyridin-2-yl)-2-methyl-benzenesulfonamide
This material was obtained in analogy to example 1 from 4,6-dimethyl-pyridin-2-ylamine and 3-chloro-2methyl-benzenesulfonyl chloride as a light yellow solid. MS (ESF): 309.1 ([M-H]").
Example 12: Biphenyl-4-sulfonic acid (4,6-dimethyI-pyridin-2-yl)-amide
This material was obtained in analogy to example 1 from 4,6-dimethyl-pyridin-2-ylamine and biphenyl-4-sulfonyl chloride as a white amorphous solid. MS (ESF): 337.0 ([M-H]-).
Example 13: N-(3-Bromo-6-methyl-pyridin-2-yl)-3-chloro-2-methyl-benzenesulfonamide
This material was obtained in analogy to example 1 from 3-bromo-6-methyl-pyridin-2-ylamine (0.2 g) and 3-chloro-2-methyl-benzenesulfonyl chloride (0.265 g) as an off-white solid (0.351 g). MS (ESF): 372.9 ([M-H]').
Example 14: Biphenyl-4-sulfonic acid (3-bromo-6-methyl-pyridin-2-yl)-amide
This material was obtained in analogy to example 1 from 3-bromo-6-methyl-pyridin-2-ylamine (0.2 g) and biphenyl-4-suIfonyl chloride (0.297 g) as a white foam (0.307 g). MS(ESI'):401.2([M-HD.
Example 15: Naphthalene-2-sulfonic acid (6-propyl-pyridin-2-yl)-amide
This material was obtained in analogy to example 1 from 6-propyl-pyridin-2-ylamine (0.2 g) and naphthalene-2-sulfonyl chloride (0.366 g) as a white foam (0.392 g). MS (ESI'): 325.2 ([M-H]').
Example 16: 4'-Chloro-biphenyl-4-sulfonic acid (6-methyl-pyridin-2-yl)-amide
This material was obtained in analogy to example 1 from 6-methyl-pyridin-2-ylamine (0.22 g) and 4'-chloro-biphenyl-4-sulfonyl chloride (0.622 g) as a white solid (0.074 g). MS (ESI'): 357.2
Example 17: 4'-Fluoro-biphenyl-4-sulfonic acid (6-methyl-pyridin-2-yl)-amide
This material was obtained in analogy to example 1 from 6-methyl-pyridin-2-ylamine (0.4 g) and 4'-fluoro-biphenyl-4-sulfonyl chloride (1 g) as a white foam (0.779 g). MS (ESF):341.1 ([M-H]").
Example 18: 3,4-Dichloro-N-(6-propyl-pyridin-2-yl)-benzenesulfonamide
This material was obtained in analogy to example 1 from 6-propyl-pyridin-2-ylamine (0.15 g) and 3,4-dichloro-benzenesulfonyl chloride (0.27 g) as a white solid (0.199 g). MS (ESF): 342.9 ([M-H]").
Example 19: 2,5-Difluoro-N-(6-propyl-pyridin-2-yl)-benzenesulfonamide

This material was obtained in analogy to example 1 from 6-propyl-pyridin-2-ylamine (0.1 g) and 2,5-difluoro-benzenesulfonyl chloride (0.17 g) as a white solid (0.114 g). MS(ESr):3I1.0([M-H]-).
Example 20: 2,4-Dichloro-6-methyl-N-(6-propyI-pyridin-2-yl)-benzenesulfonamide
This material was obtained in analogy to example 1 from 6-propyl-pyridin-2-ylamine (0.1 g) and 2,4-dichloro-6-methyl-benzenesulfonyl chloride (0.191 g) as a light brown oil. (0.039 g). MS (ESF): 357.1 ([M-H]').
Example 21: 5-ChIoro-naphthalene-2-sulfonic acid (6-propyl-pyridin-2-yl)-amide
This material was obtained in analogy to example 1 from 6-propyl-pyridin-2-ylamine (0.1 g) and 5-chloro-naphthalene-2-sulfonyl chloride (0.191 g) as white solid. (0.047 g). MS (ESF): 359.0 ([M-FTf).
Example 22: 3,4-Dimethoxy-N-(6-propyI-pyridin-2-yl)-benzenesuIfonamide
This material was obtained in analogy to example 1 from 6-propyl-pyridin-2-ylamine (0.1 g) and 3,4-dimethoxy-benzenesulfonyl chloride (0.174 g) as a colorless oil. (0.043 g). MS (ESI'): 335.2 ([M-H]').
Example 23: 4,5-Dichloro-2-fluoro-N-(6-propyl-pyridin-2-yl)-benzenesulfonamide
This material was obtained in analogy to example 1 from 6-propyl-pyridin-2-ylamine (0.1 g) and 4,5-dichloro-2-fluoro-benzenesulfonyl chloride (0.213 g) as a colorless oil. (0.176 g). MS (ESI): 363.1 (MH+).

Example 24: 2,4-DichIoro-5-methyl-N-(6-propyl-pyridin-2-yI)-benzenesulfonamide
This material was obtained in analogy to example 1 from 6-propyl-pyridin-2-ylamine (0.1 g) and 2,4-dichloro-5-methyl-benzenesulfonyl chloride (0.194 g) as a light yellow amorphous solid. (0.194 g). MS (ESF): 357.1 ([M-H]').
Example 25: Piperidine-1-sulfonic acid (6-propyI-pyridin-2-yl)-amide
A solution of 6-propyl-pyridin-2-ylamine (0.2 g) and piperidine-1-sulfonyl chloride (0.296 g, Bull. Soc. Chim. Fr.; 1936, 2143) in pyridine (7 mL) was heated to reflux for 15 h. After concentration of the reaction mixture in vacuo the residue was taken up in EtOAc, which was then washed with IN aqueous HC1, saturated brine, dried over sodium sulphate and concentrated in vacuo. The residue was applied to a silica gel column with EtOAc/toluene (9:1 to 1:1) as eluent. Combination of the purified fractions and concentration in vacuo gave the desired piperidine-1-sulfonic acid (6-propyl-pyridin-2-yl)-amide (0.133 g) as a colorless amorphous solid. MS (ESF): 282.0 ([M-H]"
Example 26: 3-Chloro-N-(6-isopropyl-pyridin-2-yl)-4-methyl-benzenesulfonamide
Step A]: 6-Isopropyl-pyridin-2-ylamine
2-Amino-6-bromopyridine (2 g) was dissolved in dioxane (50 mL), and at 0° C under an argon athmosphere l,3-bis(diphenylphosphino)propane nickel (II) chloride (0.627 g) was added followed by diisopropyl zink (23.12 mL of a IM solution in toluene, via syringe over 30 minutes). The mixture was allowed to reflux for 15 h, poored into 2-propanol, which was then concentrated in vacuo. The residue was partitioned between AcOEt and saturated aqueous NH4C1 solution, the layers were separated and the organic layer dried over Na2SO4, filtered and evaporated. The residue was purified by flash chromatography (methylene chloride/methanol 95:5) to give 6-isopropyl-pyridin-2-ylamine as high brown oil (0.48 g). MS (El): 136.1 (M+).
StepB] 3-Chloro-N-(6-isopropyl-pyridin-2-yl)-4-methyl-benzenesulfonamide
This compound was obtained in analogy to example 1 from 6-isopropyl-pyridin-2-ylarnine (0.1 g), and 3-chloro-4-methyl-benzenesulfonyl chloride (0.182 g) as a white solid (30 mg). MS (ESF): 324.1 ([M-H]').
Example 27: 2,5-Difluoro-N-(6-isopropyl-pyridin-2-yl)-benzenesulfonamide
This material was obtained in analogy to example 1 from 6-isopropyl-pyridin-2-ylamine (0.1 g) and 2,5-difluoro-benzenesulfonyl chloride (0.172 g) as a colorless foam. (20 mg). MS (ESP): 311.1 ([M-H]').
Example 28: N-(6-Isopropyl-py ridin-2-yl)-4-(4-trifluoromethyl-phenoxy)-benzenesulfonamide
This material was obtained in analogy to example 1 from 6-isopropyl-pyridin-2-ylamine (0.1 g) and 4-(4-trifluoromethyl-phenoxy)-benzenesulfonyl chloride (0.272 g) as an amorphous colorless solid (31 mg). MS (ESF): 435.1 ([M-H]-).
Example 29: 2,4-Dichloro-N-(6-isopropyl-pyridin-2-yl)-5-methyl-benzenesulfonamide
This material was obtained in analogy to example 1 from 6-isopropyl-pyridin-2-ylamine (0.1 g) and 2,4-dichloro-5-methyl-benzenesulfonyl chloride (0.194 g) as an amorphous light yellow solid (35 mg). MS (ESF): 357.2 ([M-H]').
Example 30: N-(6-isopropyl-pyridin-2-yl)-4-methanesuIfonyl-benzenesulfonamide
This material was obtained in analogy to example 1 from 6-isopropyl-pyridin-2-ylamine (0.1 g) and 4-methylsulfonyl-benzenesulfonyl chloride (0.206 g) as a white foam (46.8 mg). MS (ESF): 353.1 ([M-H]').
Example 31: N-(6-lsopropyl-pyridin-2-yl)-4-trifluoromethoxy-benzenesulfonamide
This material was obtained in analogy to example 1 from 6-isopropyl-pyridin-2-ylamine (0.1 g) and 4-(trifluoromethoxy)-benzenesulfonyl chloride (0.21 g) as an amorphous colorless solid (40 mg). MS (ESF): 359.0 ([M-H]').
Example 32: 2-(2,2,2-Trifluoro-acetyI)-l,2,3,4-tetrahydro-isoquinoline-7-sulfonic acid (6-isopropyl-pyridin-2-yl)-amide
This material was obtained in analogy to example 1 from 6-isopropyl-pyridin-2-ylamine (0.08 g) and 2-(2,2,2-trifluoro-acetyl)-l,2,3,4-tetrahydro-isoquinoline-7-sulfonyl chloride (0.212 g) as a white foam (35.2 mg). MS (ESF): 426.2 ([M-H]').
Example 33: N-(6-Isopropyl-pyridin-2-yl)-3-(4-trifluoromethyl-phenoxy)-benzenesulfonamide
This material was obtained in analogy to example 1 from 6-isopropyl-pyridin-2-ylamine (0.08 g) and 3-(4-trifluoromethyl-phenoxy)-benzenesulfonyl chloride (0.218 g) as an amorphous light yellow solid (37 mg). MS (ESF): 435.1 ([M-H]').
Example 34: Naphthalene-2-sulfonic acid (6-isopropyl-pyridin-2-yl)-amide
This material was obtained in analogy to example 1 from 6-isopropyl-pyridin-2-ylamine (0.07 g) and naphthalene-2-sulfonyl chloride (0.128 g) as an amorphous light yellow solid (51 mg). MS (ESF): 325.2 ([M-H]').
Example 35: N-(6-Isopropyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide
This material was obtained in analogy to example 1 from 6-isopropyl-pyridin-2-ylamine (0.06 g) and 3-(trifluoromethyl)-benzenesulfonyl chloride (0.119 g) as an amorphous colorless solid (38.3 mg). MS (ESF): 343.0 ([M-H]').
Example 36: N-[6-(2-Chloro-phenyl)-pyridin-2-yl]-5-fluoro-2-methyI-benzenesulfonamide
Step A]: 6-(2-Chloro-phenyl)-pyridin-2-ylamine
2-Amino-6-bromopyridine (1 g) and 2-chlorophenylboronic acid (1.039 g) were dissolved in toluene/ethanol (30 mL/3 mL) and at RT under an argon atmosphere treated with 2N aqueous sodium carbonate solution (6.13 mL). The mixture was stirred for 30 minutes at RT then treated with tetrakis(triphenylphosphine) palladium(O), 0.267 g, and heated to reflux for 24 h. The mixture was then cooled to RT and partitioned between AcOEt and water, the layers were separated and the organic layer dried over NaaSCX filtered and evaporated. The residue was purified by flash chromatography (heptane/AcOEt 4:1) to give 6-(2-chloro-phenyl)-pyridin-2-ylamine as white solid (0.632 g). MS (El): 204 (M+).
StepB]: N-[6-(2-Chloro-phenyl)-pyridin-2-yl]-5-fluoro-2-methyl-benzenesulfonamide
This compound was obtained in analogy to example 1 from 6-(2-chloro-phenyl)-pyridin-2-ylamine (0.1 g), and 5-fluoro-2-methyl-benzenesulfonyl chloride (0.112 g) as a white solid (89.3 mg). MS (ESI"): 375.2 ([M-H]').
Example 37: 3-Chloro-N-[6-(2-chloro-phenyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide
This material was obtained in analogy to example 1 from 6-(2-chloro-phenyl)-pyridin-2-ylamine (0.1 g) and 3-(chloro)-2-methyl-benzenesulfonyl chloride (0.12 g) as an off-white foam (129 mg). MS (ESF): 390.9 ([M-H]-).
Example 38: Biphenyl-4-sulfonic acid [6-(2-chloro-phenyl)-pyridin-2-yl]-amide
This material was obtained in analogy to example 1 from 6-(2-chloro-phenyl)-pyridin-2-ylamine (0.1 g) and biphenyl-4-sulfonyl chloride (0.136 g) as an white foam (126 mg). MS (ESF): 419.0 ([M-H]").
Example 39: 3-Chloro-N-[6-(2,4-difluoro-phenyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide
Step A]: 6-(2,4-Difluoro-phenyl)-pyridin-2-ylamine
This material was obtained in analogy to example 36 step A] from 2-Amino-6-bromopyridine (1 g) and 2,4-difluorophenylboronic acid (1.05 g) as a yellow solid (1.26 g). MS (ESI): 207.2 (MH+).
Step BJ: 3-Chloro-N-[6-(2,4-difluoro-phenyl)-pyridin-2-yI]-2-methyl-
benzenesulfonamide
This material was obtained in analogy to example 1 from 6-(2,4-difluoro-phenyl)-pyridin-2-ylamine (0.1 g), and 3-chloro-2-methyl-benzenesulfonyl chloride (0.12 g) as a white solid (0.132 g). MS (ESF): 392.9 ([M-H]").
Example 40 3-Chloro-N-[6-(3-fluoro-phenyl)-pyridin-2-yl]-2-methyI-benzenesulfonamide
Step A]: 6-(3-Fluoro-phenyl)-pyridin-2-ylamine
This material was obtained in analogy to example 36 step A] from 2-Amino-6-bromopyridine (0.75 g) and 3-fluorophenylboronic acid (0.7 g) as a yellow oil (0.81 g). MS (ESI): 189.3(MH+).
Step B]: 3-Chloro-N-[6-(3-fluoro-phenyl)-pyridin-2-yl]-2-methyl-
benzenesulfonamide
This material was obtained in analogy to example 1 from 6-(3-fluoro-phenyl)-pyridin-2-ylarnine (0.1 g), and 3-chloro-2-methyl-benzenesulfonyl chloride (0.132 g) as a white solid (0.144 g). MS (ESF): 375.1 ([M-H]').
Example 41 3-ChIoro-N-[6-(2^-difluoro-phenyl)-pyridin-2-yl]-2-methyI-benzenesulfonamide
Step A]: 6-(2,3-Difluoro-phenyl)-pyridin-2-ylamine
This material was obtained in analogy to example 36 step A] from 2-Amino-6-bromopyridine (0.75 g) and 2,3-difluorophenylboronic acid (0.787 g) as a yellow solid (0.84 g). MS (ESI): 207.2 (MH+).
Step B]: 3-Chloro-N-[6-(2,3-difluoro-phenyl)-pyridin-2-yl]-2-methyl-
benzenesulfonamide
This material was obtained in analogy to example 1 from 6-(2,3-difluoro-phenyl)-pyridin-2-ylamine (0.1 g), and 3-chloro-2-methyl-benzenesulfonyl chloride (0.12 g) as a white solid (0.115 g). MS (ESF): 392.9 ([M-H]').
Example 42 3-Chloro-N-[6-(2,5-dichloro-phenyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide
Step A]: 6-(2,5-Dichloro-phenyl)-pyridin-2-ylamine
This material was obtained in analogy to example 36 step A] from 2-Amino-6-bromopyridine (0.75 g) and 2,5-dichlorophenylboronic acid (0.951 g) as an off-white solid (0.87 g). MS (ESI): 239.1 (MH+).
Step B]: 3-Chloro-N-[6-(2,5-dichloro-phenyl)-pyridin-2-yl]-2-methyl-
benzenesu I fonam ide
This material was obtained in analogy to example 1 from 6-(2,5-dichloro-phenyl)-pyridin-2-ylamine (0.1 g), and 3-chloro-2-methyl-benzenesulfonyl chloride (0.104 g) as a white solid (0.094 g). MS (ESI"): 425.0 ([M-H]").
Example 43: N-[6-(2,5-Dichloro-phenyl)-pyridin-2-yl]-5-fluoro-2-methyI-benzenesulfonamide
This material was obtained in analogy to example 1 from 6-(2,5-dichloro-phenyl)-pyridin-2-ylamine (0.1 g) and 5-fluoro-2-methyl-benzenesulfonyl chloride (0.096 g) as an white solid (142 mg). MS (ESI"): 409.0 ([M-H]").
Example 44 3-Chloro-N-[6-(3-chloro-phenyI)-pyridin-2-yl]-2-methyl-benzenesulfonamide
Step A]: 6-(3-Chloro-phenyl)-pyridin-2-ylamine
This material was obtained in analogy to example 36 step A] from 2-Amino-6-bromopyridine (0.75 g) and 3-chlorophenylboronic acid (0.75 g) as an off-white solid (0.87 g). MS (ESI): 205.1 (MH+).
Step B]: 3-Chloro-N-[6-(3-chloro-phenyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide
This material was obtained in analogy to example 1 from 6-(3-chloro-phenyl)-pyridin-2-ylamine (0.1 g), and 3-chloro-2-methyl-benzenesulfonyl chloride (0.12 g) as a white solid (0.132 g). MS (ESI"): 391.0 ([M-H]").
Example 45: N-[6-(3-Chloro-phenyl)-pyridin-2-yl]-5-fluoro-2-methyl-benzenesulfonamide
This material was obtained in analogy to example 1 from 6-(3-chloro-phenyl)-pyridin-2-yIamine (0.1 g) and 5-fluoro-2-methyl-benzenesulfonyl chloride (0.112 g) as a white solid (172 mg). MS (ESI"): 375.2 ([M-H]").

Example 46 3-Chloro-N-[6-(2-fluoro-phenyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide
Step A]: 6-(2-Fluoro-phenyl)-pyridin-2-ylamine
This material was obtained in analogy to example 36 step A] from 2-Amino-6-bromopyridine (0.75 g) and 2-fluorophenylboronic acid (0.7 g) as an off-white solid (0.789 g). MS (ESI): 189.2 (MH+).
Step B]: 3-Chloro-N-[6-(2-fluoro-phenyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide
This material was obtained in analogy to example 1 from 6-(2-fluoro-phenyl)-pyridin-2-ylamine (0.1 g), and 3-chloro-2-methyl-benzenesulfonyl chloride (0.132 g) as a light-yellow solid (0.135 g). MS (ESF): 375.2 ([M-H]').
Example 47: 5-Fluoro-N-[6-(2-fluoro-phenyl)-pyridin-2-yl] -2-methyl-benzenesulfonamide
This material was obtained in analogy to example 1 from 6-(2-fluoro-phenyl)-pyridin-2-ylamine (0.1 g) and 5-fluoro-2-methyl-benzenesulfonyl chloride (0.12 g) as an off-white solid (0.19 g). MS (ESF): 359.0 ([M-H]').
Example 48 3-Chloro-2-methyl-N-[6-(2-trifluoromethyl-phenyl)-pyridin-2-yl)-benzenesulfonamide
Step A]: 6-(2-Trifluoromethyl-phenyl)-pyridin-2-ylamine
This material was obtained in analogy to example 36 step A] from 2-Amino-6-bromopyridine (0.7 g) and 2-(trifluoromethyl)phenylboronic acid (0.884 g) as a yellow solid (0.35 g). MS (ESI): 239.2 (MH*).
Step B]: 3-Chloro-2-methyl-N-[6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-
benzenesulfonamide
This material was obtained in analogy to example 1 from 6-(2-trifluoromethyl-phenyl)-pyridin-2-ylamine (0.1 g), and 3-chloro-2-methyl-benzenesulfonyl chloride (0.086 g) as a a white solid (0.08 g). MS (ESF): 425.1 ([M-H]").
Example 49: 5-Fluoro-2-methyl-N-[6-(2-trifluoromethyI-phenyl)-pyridin-2-yl]-benzenesulfonamide
This material was obtained in analogy to example 1 from 6-(2-trifluoromethyl-phenyl)-pyridin-2-ylamine (0.1 g) and 5-fluoro-2-methyl-benzenesulfonyl chloride (0.088 g) as an amorphous light brown solid (0.139 g). MS (ESr): 409.1 ([M-H]-).
Example 50: N-[6-(2-Chloro-phenyl)-pyridin-2-yl]-2,5-difluoro-benzenesuifonamide
This material was obtained in analogy to example 1 from 6-(2-chloro-phenyl)-pyridin-2-ylamine (0.08 g) and 2,5-difluoro-benzenesulfonyl chloride (0.09 g) as a white foam (0.127 g). MS (ESF): 379.0 ([M-H]').
Example 51: N-[6-(2-Chloro-phenyl)-pyridin-2-yI]-2-trifluoromethyl-benzcnesulfonamide
This material was obtained in analogy to example 1 from 6-(2-chloro-phenyl)-pyridin-2-ylamine (0.08 g) and 2-(trifluoromethyl)-benzenesulfonyl chloride (0.105 g) as an amorphous light yellow solid (0.167 g). MS (ESI'): 411.0 ([M-H]').
Example 52 3-Chloro-N-[6-(2-methoxy-phenyI)-pyridin-2-yl]-2-methyl-benzenesulfonamide
Step A]: 6-(2-Methoxy-phenyl)-pyridin-2-ylamine
This material was obtained in analogy to example 36 step A] from 2-Amino-6-bromopyridine (0.75 g) and 2-methoxyphenylboronic acid (0.758 g) as a crystalline yellow solid (0.76 g). MS (ESI): 201.1 (MH+).
Step B]: 3-Chloro-N-[6-(2-methoxy-phenyl)-pyridin-2-yl]-2-methyl-
benzenesulfonamide
This material was obtained in analogy to example 1 from 6-(2-methoxy-phenyl)-pyridin-2-ylamine (0.1 g), and 3-chloro-2-methyl-benzenesulfonyl chloride (0.102 g) as a colorless oil (0.091 g). MS (ESF): 387.1 ([M-H]').
Example S3 3-ChIoro-N-[6-(4-fluoro-2-methyl-phenyl)-pyridin-2-yl]-2-raethyl-benzenesulfonamide
Step A]: 6-(4-FIuoro-2-methyl-phenyl)-pyridin-2-ylamine
This material was obtained in analogy to example 36 step A] from 2-Amino-6-bromopyridine (0.75 g) and 4-fluoro-2-methyl-phenylboronic acid (0.767 g) as a yellow solid (0.828 g). MS (ESI): 203.1 (MH+).
Step B]: 3-Chloro-N-[6-(4-fluoro-2-methyl-phenyl)-pyridin-2-yl]-2-methyl-
benzenesu 1 fonam ide
This material was obtained in analogy to example 1 from 6-(4-fluoro-2-methyl-phenyl)-pyridin-2-ylamine (0.1 g), and 3-chloro-2-methyl-benzenesulfonyl chloride (0.101 g) as a white solid (0.097 g). MS (ESI'): 389.0 ([M-H]').
Example 54: 5-Fluoro-N-[6-(4-fluoro-2-methyl-phenyl)-pyridin-2-yI]-2-methyl-benzenesulfonamide
This material was obtained in analogy to example 1 from 6-(4-fluoro-2-methyl-phenyl)-pyridin-2-ylamine (O.I g) and 5-fluoro-2-methyl-benzenesulfonyl chloride (0.103 g) as an colorless oil (0.101 g). MS (ESF): 373.1 ([M-H]").
Example 55 N-[2,3']Bipyridinyl-6-yl-3-chloro-2-methyl-benzenesulfonamide
Step A]: [2,3']Bipyridinyl-6-ylamine
This material was obtained via a Stille type coupling from 2-Amino-6-bromopyridine (0.75 g), 3-tributylstannanyl-pyridine (4.787 g), tetrakis(triphenylphosphine) palladium(O), 0.55 g, in DMF (5 mL) as solvent, by heating the mixture under argon at 100°C for 16 h, subsequent work-up as described in example 36 step A], and isolation of [2,3']bipyridinyl-6-ylamine by flash chromatography (heptane/AcOEt 1:4 then methylene chloride/methanol 95:5) as as an amorphous yellow solid (0.179 g). MS (ESI): 172.1 (MH+).
StepB]: N-[2,3']Bipyridinyl-6-yl-3-chloro-2-methyl-benzenesulfonamide
This material was obtained in analogy to example 1 from [2,3']Bipyridinyl-6-ylamine (0.07 g), and 3-chloro-2-methyl-benzenesulfonyl chloride (0.101 g) as a yellow solid (5.5 mg). MS (ESf): 358.0 ([M-H]").
Example 56: 2,5-Difluoro-N-[6-(4-fluoro-2-methyl-phenyl)-pyridin-2-yIJ-benzenesulfonamide
This material was obtained in analogy to example 1 from 6-(4-fluoro-2-methyl-phenyl)-pyridin-2-ylamine (0.1 g) and 2,5-difluoro-benzenesulfonyl chloride (0.105 g) as an orange solid (0.052 g). MS (ESF): 377.2 ([M-H]').
Example 57: 2,4-Dichloro-N-[6-(4-fluoro-2-methyl-phenyl)-pyridin-2-yl|-6-methyl-benzenesulfonamide
This material was obtained in analogy to example 1 from 6-(4-fluoro-2-methyl-phenyl)-pyridin-2-ylamine (0.1 g) and 2,4-dichloro-6-methyl-benzenesulfonyl chloride (0.128 g) as a white solid (0.118 g). MS (ESF): 422.9 ([M-HD-
Example 58: 3,4-DichIoro-N-[6-(4-fluoro-2-methyl-phenyl)-pyridin-2-yI]-benzenesulfonamide
This material was obtained in analogy to example 1 from 6-(4-fluoro-2-methyl-phenyl)-pyridin-2-ylamine (0.1 g) and 3,4-dichloro-benzenesulfonyl chloride (0.121 g) as a white solid (0.182 g). MS (ESF): 409.0 ([M-Hp).
Example 59: 3-Chloro-N-(6-methoxy-pyridin-2-yl)-2-methyl-benzenesulfonamide
This material was obtained in analogy to example 1 from 6-methoxy-pyridin-2-ylamine (0.25 g, Bernstein, J. Amer. Chem Soc., 69, 1947, 1147) and 3-chloro-2-methyl-benzenesulfonyl chloride (0.495 g) as a purple crystalline solid (0.38 g). MS (ESI"):
Example 60: Biphenyl-4-sulfonic acid (6-methoxy-pyridin-2-yl)-amide
This material was obtained in analogy to example 1 from 6-methoxy-pyridin-2-ylamine (0.25 g) and biphenyl-4-sulfonyl chloride (0.5 g) as a white solid (0.41 g). MS (ESF): 339.0 ([M-H]').
Example 61: 5-Fluoro-N-(6-methoxy-pyridin-2-yl)-2-methyl-benzenesulfonamide
This material was obtained in analogy to example 1 from 6-methoxy-pyridin-2-ylamine (0.25 g) and 5-fluoro-2-methyl-benzenesulfonyl chloride (0.45 g) as a red crystalline solid (0.38 g). MS (ESI'): 295.1 ([M-H]').
Example 62: Naphthalene-2-sulfonic acid (6-methoxy-pyridin-2-yI)-amide
This material was obtained in analogy to example 1 from 6-methoxy-pyridin-2-ylamine (0.25 g) and naphthalene-2-sulfonyl chloride (0.49 g) as a light red waxy solid (0.5 g). MS(ESO:312.9([M-H]').
Example 63: 3-ChIoro-N-(6-ethoxy-pyridin-2-yl)-2-methyl-benzenesulfonamide
This material was obtained in analogy to example 1 from 6-ethoxy-pyridin-2-ylamine (0,4 g, Bijlsma, Reel. Trav. Chim. Pays-Bas, 75, 1956, 1187) and 3-chloro-2-methyl-benzenesulfonyl chloride (0.7 g) as a light brown crystalline solid (0.6 g). MS (ESI"): 325.1 ([M-H]').
Example 64: Biphenyl-4-sulfonic acid (6-ethoxy-pyridin-2-yl)-amide
This material was obtained in analogy to example 1 from 6-ethoxy-pyridin-2-ylamine (0.4 g) and biphenyl-4-sulfonyl chloride (0.74 g) as a light brown viscous oil (1 g). MS (ESF): 353.1 ([M-H]').
Example 65: Naphthalene-2-suifonic acid (6-ethoxy-pyridin-2-yl)-amide
This material was obtained in analogy to example 1 from 6-ethoxy-pyridin-2-ylamine (0.4 g) and naphthalene-2-sulfonyl chloride (0.7 g) as a light brown crystalline solid (0.7 g). MS (ESP): 327.2
Example 66: 3-Chloro-N-(6-ethylsulfanyl-pyridin-2-yl)-2-methyl-benzenesulfonamide
Step A]: 6-Ethylsulfanyl-pyridin-2-ylamine
2-Amino-6-bromopyridine (0.88 g) and sodium ethanethiolate (0.46 g) were dissolved in DMF (10 mL) stirred at RT for 20 h and subsequently at 60°C for further 20 h to complete the reaction according to HPLC analysis. The mixture was concentrated in vacuo, partitioned between AcOEt and water, the layers were separated and the organic layer dried over Na2SC4, filtered and evaporated to give to give 6-ethylsulfanyl-pyridin-2-ylamine as brown oil (1.6 g) that was used directly in the next reaction step.
Step B]: N-[6-(2-Chloro-phenyl)-pyridin-2-yl]-5-fluoro-2-methyl-benzenesulfonamide
This compound was obtained in analogy to example 1 from 6-ethylsulfanyl-pyridin-2-ylamine (0.44 g), and 3-chloro-2-methyl-benzenesulfonyl chloride (0.7 g) as a light brown viscous oil (0.7 g). MS (ESF): 341.1 ([M-H]-).
Example 67: Biphenyl-4-sulfonic acid (6-ethylsulfanyl-pyridin-2-yl)-amide
This material was obtained in analogy to example 1 from 6-ethylsulfanyl-pyridin-2-ylamine (0.44 g) and biphenyl-4-sulfonyl chloride (0.78 g) as a light brown viscous oil (0.53 g). MS (ESF): 369.0 ([M-H]").
Example 68: Naphthalene-2-sulfonic acid (6-ethylsulfanyl-pyridin-2-yl)-amide
This material was obtained in analogy to example 1 from 6-ethylsulfanyl-pyridin-2-ylamine (0.44 g) and naphthalene-2-sulfonyl chloride (0.7 g) as a light brown viscous oil (1 g). MS (ESF): 342.9 ([M-H]').
Example 69: Naphthalene-2-sulfonic acid (6-ethanesulfonyl-pyridin-2-yl)-amide
A solution of naphthalene-2-sulfonic acid (6-ethylsulfanyl-pyridin-2-yl)-amide (0.15 g, product of example 68) in CFbCh (20 mL) was treated dropwise at RT with 3-chloroperoxybenzoic acid acid (0.15 g) in 5 mL CHaCb) and stirred for 2 h at RT. The reation mixture was washed with diluted aqueous Na2CC>3 and water, then dried over Na2SC>4, filtered and evaporated. The residue was purified by flash chromatography (toluene/EtOAc 1:1) to give naphthalene-2-sulfonic acid (6-ethanesulfonyl-pyridin-2-yl)-amide as a white foam (60 mg). MS (ESI'): 375.2 ([M-H]*).
Example 70: 3-Chloro-2-methyl-N-[6-(2-oxo-pentyl)-pyridin-2-yl]-benzenesulfonamide
Step A]: 1 -(6-Amino-pyridin-2-yl)-pentan-2-one
1,1,1,3,3,3-Hexamethyl-2-(6-methyl-pyridin-2-yl)-disilazane (1 g, Engelhardt, J. Chem. Soc. Chem. Commun.,1990, 89) under an argon atmosphere in THF (20 mL) was

cooled to -20°C and treated dropwise at -20°C with 4.95 mL of a 1.6 M solution of N-butyllithium in hexane over a period of 1 h. The solution was stirred 1 h at -20°C , N-butyronitrile (0.301 g) was added and the mixture was allowed to warm to RT. It was then treated with 1.25 N HCL in methanol (6.34 ml) and stirred for 30 minutes at RT. The mixture was poored into water water (pH 1) and extracted with AcOEt that was discarded, the water layer was brought to pH 8 with solid KHCO3 and extracted twice with AcOEt. The layers were separated, the organic layer dried over NaaSO^ filtered and evaporated to give l-(6-Amino-pyridin-2-yl)-pentan-2-one as viscous yellow oil (0.34 g) that was used without further purification in the next step. MS (El): 179.2
StepB]: 3-Chloro-2-methyl-N-[6-(2-oxo-pentyl)-pyridin-2-yl]-benzenesulfonamide
l-(6-Amino-pyridin-2-yl)-pentan-2-one (0.15 g) in CP^Ch (5 mL) was treated at RT with 4-dimethylaminopyridine (0.103 g), 3-chloro-2-methyl-benzenesulfonyl chloride (0.208 g) and stirred at RT for 16 h. The mixture was partitioned between cold diluted aqueous HC1 and AcOEt, the layers were separated, and the organic layer twice extracted with AcOEt. The combined organic layers were dried over NaaSO^ filtered and evaporated. From the the residue was isolated by flash chromatography (heptane/EtOAc 1:1) the vinyl sulfonate 3-chloro-2-methyl-benzenesulfonic acid 1-[1-[6-(3-chloro-2-methyl-benzenesulfonylamino)-pyridin-2-yl]-meth-(Z)-ylidene]-butyl ester (23 mg) as an amorphous off-white solid (27 mg). MS (ESF): 552.8 ([M-H]').
This material was hydrolysed to the desired product as following: 20 mg of above material in methanol (3 mL) was treated with 0.035 mL 2N NaOH in methanol and heated to reflux for 1,5 h. The mixture was partitioned between water and AcOEt and the aqueous layer adjusted to pH 7. The layers were separated, the organic layer dried over Na2SO4, filtered and evaporated to give 3-chloro-2-methyl-N-[6-(2-oxo-pentyl)-pyridin-2-yl]-benzenesulfonamide (12 mg) as an amoprphous light yellow solid. MS (ESP): 365.0 ([M-H]').
Example 71: 2-[6-(Biphenyl-4-sulfonylamino)-pyridin-2-yl]-N,N-diethyl-acetamide
Step A]: [6-(Biphenyl-4-sulfonylamino)-pyridin-2-yl]-acetic acid

Biphenyl-4-sulfonic acid (6-methyl-pyridin-2-yl)-amide (0.5 g, product of example 5) under an argon atmosphere in THF (5 mL) was cooled to -20°C and treated dropwise at -20°C with 1.54 mL of a 2 M solution of lithium diisopropylamide in THF/heptane/ethylbenzene (Fluka), The solution was stirred 1 h at -20°C , cooled to -70°C and then treated with an access of dry ice. The mixture was allowed to warm to RT (1 h), partitioned between diluted aqueous HC1 and AcOEt. The layers were separated, the aqueous layer extracted twice with AcOEt, the combined organic layers dried over Na2SO4, filtered and evaporated to give [6-(biphenyl-4-sulfonylamino)-pyridin-2-yl]-acetic acid as light yellow gum (0.779 g) that was used without further purificatiation in the next step.
StepB]: 2-[6-(Biphenyl-4-sulfonylamino)-pyridin-2-yl]-N,N-diethyl-acetamide
[6-(Biphenyl-4-sulfonylamino)-pyridin-2-yl]-acetic acid (0.35 g) in acetonitrile (5 mL) was treated at RT with N,N-ethyldiisopropylamine (0.16 mL), benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate (BOP, 0.252 g) then diethylamine (0.05 mL), and the mixture was stirred at RT for 16 h. It was then partitioned between cold diluted aqueous HC1 and AcOEt, the layers were separated, the organic layer dried over NaaSO^ filtered and evaporated. The residue was purified by flash chromatography (heptane/EtOAc 1:1) to give 2-[6-(biphenyl-4-sulfonylamino)-pyridin-2-yl]-N,N-diethyl-acetamide as a yellow solid (0.168 g). MS (ESF): 422.2 ([M-
Example 72: Biphenyl-4-sulfonic acid [6-(2-morpholin-4-yI-2-oxo-ethyl)-pyridin-2-yl]-amide
This material was obtained in analogy to example 71 Step B] from [6-(biphenyl-4-sulfonylamino)-pyridin-2-yl]-acetic acid (0.16 g), BOP (0.23 g), N,N-ethyldiisopropylamine (0.15 mL) and morholine (0.042 g) as a light brown solid (67 mg). MS (ESF): 436.2 ([M-H]').
Example 73: [6-(3-Chloro-2-methyl-benzenesulfonylamino)-pyridin-2-yl]-acetic acid methyl ester

Step A]: (6-Amino-pyridin-2-yl)-acetic acid methyl ester
l,l,l,3,3,3-Hexamethyl-2-(6-methyl-pyridin-2-yl)-disilazane (1.7 g) under an argon atmosphere in THF (20 mL) was cooled to -20°C and treated dropwise at -20°C with 6.73 mL of a 2 M solution of lithium diisopropylamide in THF/heptane/ethylbenzene (Fluka). The solution was stirred 1 h at -20°C, cooled to -70°C and then treated with an access of dry ice. The mixture was allowed to warm to 0°C and then quenched with trifluoro-acetic acid(0.57 ml) and concentrated in vacuo. The residue was taken up in MeOH and added dropwise to a solution of thionyl chloride (9.77 mL) in MeOH (30 ml) at 0°C. The reaction mixture was then heated to reflux for 24 h, cooled to RT and concentrated in vacuo. The residue was partitioned between aqueous diluted NaHCOs and AcOEt, the layers were separated, the organic layer dried over Na2SC>4, filtered, evaporated and the residue purified by flash chromatography (heptane/AcOEt 1:1) to give (6-amino-pyridin-2-yl)-acetic acid methyl ester as a crystalline off-white solid (0.429 g). MS (El): 166.0 (Ivf).
Step B]: [6-(3-Chloro-2-methyl-benzenesulfonylamino)-pyridin-2-yl]-acetic acid methyl ester
This material was obtained in analogy to example 1 from (6-amino-pyridin-2-yl)-acetic acid methyl ester (0.15 g) and 3-chloro-2-methyl-benzenesulfonyl chloride (0.223 g) as a light brown gum (14 mg). MS (ESF): 353.1 ([M-H]").
Example 74: [6-(5-FIuoro-2-methyl-benzenesulfonylamino)-pyridin-2-yl]-acetic acid methyl ester
This material was obtained in analogy to example 1 from (6-amino-pyridin-2-yl)-acetic acid methyl ester (0.15 g) and 5-fluoro-2-methyl-benzenesulfonyl chloride (0.207 g) as a tight brown gum (20 mg). MS (ESF): 337.0 ([M-H]").
Example 75: N,N-Diethyl-2-[6-(4'-fluoro-biphenyl-4-sulfonylamino)-pyridin-2-yl]-acetamide
Step A]: [6-(4'-Fluoro-biphenyl-4-sulfonylamino)-pyridin-2-yl]-acetic acid

This material was obtained in analogy to example 71 step A] from 4'-fluoro-biphenyl-4-sulfonic acid (6-methyl-pyridin-2-yl)-amide (0.5 g, product of example 17), 1.46 mL of a 2 M lithium diisopropylamide solution in THF/heptane/ethylbenzene, and dry ice to give [6-(4'-fluoro-biphenyl-4-sulfonylamino)-pyridin-2-yl]-acetic acid as a gum (0.69 g) that was used without further purification in the next step.
Step B]: N,N-Diethyl-2-[6-(4'-fluoro-biphenyl-4-sulfonylamino)-pyridin-2-yl]-
acetamide
This material was obtained in analogy to example 71 step B] from [6-(4'-fluoro-biphenyl-4-sulfonylamino)-pyridin-2-yl]-acetic acid (0.2 g), BOP (0.137 g), N,N-ethyldiisopropylamine (0,09 mL), and diethylamine (0.03 mL) as an off-white foam (0.107 g). MS (ESF): 440.2 ([M-H]").
Example 76: 4'-Fluoro-biphenyl-4-sulfonic acid [6-(2-morpholin-4-yl-2-oxo-ethyI)-pyridin-2-yl)-amide
This material was obtained in analogy to example 71 step B] from [6-(4'-fluoro-biphenyl-4-sulfonylamino)-pyridin-2-yl]-acetic acid (0.2 g), BOP (0.137 g), N,N-ethyldiisopropylamine (0.067 mL), and morpholine (0.02 mL) as an off-white solid (0.114 g). MS (ESF): 454.2 ([M-H]").
Example 77: 2-[6-(4'-Fluoro-biphenyl-4-sulfonylamino)-pyridin-2-yl]-N-(2-methoxy-ethyl)-acetamide
This material was obtained in analogy to example 71 step B] from [6-(4'-fluoro-biphenyl-4-sulfonylamino>pyridin-2-yl]-acetic acid (0.1 g), BOP (0.069 g), N,N-ethyldiisopropylamine (0.04 mL), and 2-methoxyethylamine (0.01 mL) as an amorphous light brwon solid (0.0475g). MS (ESF): 444.2 ([M-H]").
Example 78: 2-[6-(3-Chloro-2-methyl-benzenesulfonylamino)-pyridin-2-yl]-N,N-diethyl-acetamide

Step A]: (6-tert-Butoxycarbonylamino-pyridin-2-yl)-acetic acid
(6-Methyl-pyridin-2-yl)-carbamic acid tert-butyl ester (1.04 g, Pitts, J. Med. Chem., 43, 2000, 27) under an argon atmosphere in THF (40 mL) was cooled to -20°C and treated dropwise at -20°C with 5.5 mL of a 2 M solution of lithium diisopropylamide in THF/heptane/ethylbenzene (Fluka). The solution was stirred 1 h at -20°C, cooled to -70°C and then treated with an access of dry ice. The mixture was allowed to warm to 10°C and partitioned between aqueous IN HC1 and AcOEt, the layers were separated, the organic layer dried over NaaSO^ filtered, evaporated and the residue was purified by flash chromatography (MeOH/CI-kCh 0-15%). The obtained material was triturated with ether, the crystalline solid obtained was filtered off by suction and dried in vacuo to give (6-tert-butoxycarbonylamino-pyridin-2-yl)-acetic acid as an off-white solid (0.3 g).MS(ESr):251.1([M.HT).
Step B]; (6-Diethylcarbamoylmethyl-pyridin-2-yl)-carbamic acid tert-butyl ester
This material was obtained in analogy to example 71 step B] from (6-tert-butoxycarbonylamino-pyridin-2-yl)-acetic acid (0.298 g), BOP (0.575 g), N,N-ethyldiisopropylamine (0.42 mL), and diethylamine (0.14 mL) as a yellow gum (0.202 g). MS (ESI): 308.3 (MH+).
Step C]: 2-(6-Amino-pyridin-2-yl)-N,N-diethyl-acetamide
(6-Diethylcarbamoylmethyl-pyridin-2-yl)-carbamic acid tert-butyl ester (0.2 g) in CFbC^ (10 mL) was treated at RT with trifluoro-acetic acid (0.5 mL) and the solution was stirred for 1,5 h until the reaction was complete according to tic analysis. The mixture was allowed to warm to 10°C and partitioned between aqueous diluted KHCCb and AcOEt, the layers were separated, the organic layer dried over Na2SO4, filtered, evaporated to give 2-(6-amino-pyridin-2-yl)-N,N-diethyl-acetamide (148 mg) as a light yellow solid that was directly used in the next step.
Step DJ: 2-[6-(3-Chloro-2-methyl-benzenesulfonylamino)-pyridin-2-yl]-N,N-diethyl-acetamide

This material was obtained in analogy to example 1 from 2-(6-amino-pyridin-2-yl)-N,N-diethyl-acetamide (0.07 g) and 3-chloro-2-methyl-benzenesulfonyl chloride (0.084 g) as a light yellow foam (41 mg). MS (ESF): 394.0 ([M-H]*).
Example 79: 2-[6-(3,4-DichIoro-benzenesulfonyIamino)-pyridin-2-yl]-N,N-diethyl-acetamide
This material was obtained in analogy to example 1 from 2-(6-amino-pyridin-2-yl)-N,N-diethyl-acetamide (0.07 g, product of example 78 step C]) and 3,4-dichloro-benzenesulfonyl chloride (0.091 g) as an amorphous yellow solid (41 mg). MS (ESI"): 414.1 ([M-H]').
Example 80: 2-|6-(3-Chloro-2-methyl-benzenesulfonylarnino)-3-rnethyl-pyridin-2-ylJ-N,N-diethyI-acetamide
Step A]: (3-Bromo-6-tert-butoxycarbonylamino-pyridin-2-yl)-acetic acid
This material was obtained in analogy to example 78 step A] from (5-bromo-6-methyl-pyridin-2-yl)-carbamic acid tert-butyl ester, 4.3 g - prepared from 6-methyl-pyridin-2-yl)-carbamic acid tert-butyl ester, example 78 step A] via bromination with NBS/AIBN, using a procedure described by Manabu, Chem. Lett. 1995, 614 - 2M lithium diisopropylamide solution (16.5 mL) and an access of dry ice as a crystalline solid (2.6 g) that was used directly without further purification in the next reaction step.
Step Bj: (5-Bromo-6-diethylcarbamoylmethyl-pyridin-2-yl)-carbamic acid tert-butyl ester
This material was obtained in analogy to example 78 step B] from (3-bromo-6-tert-butoxycarbonylamino-pyridin-2-yl)-acetic acid (0.662 g), BOP (0.974 g), N,N-ethyldiisopropylamine (0.78 mL), and diethylamine (0.23 mL) as a light brown solid (0.67 g). MS (ESI): 386.3. (MH+).

Step C]: (6-Diethylcarbamoylmethyl-5-methyl-pyridin-2-yl)-carbamic acid tert-butyl ester
(5-Bromo-6-diethylcarbamoylmethyl-pyridin-2-yl)-carbamic acid tert-butyl ester (0.116 g in dioxane (5 mL) was treated successively at RT with potassium carbonate (0.124 g), tetrakis(triphenylphosphine) palladium(O), 35 mg, and trimethylboroxine (38 mg) and then heated to reflux for 22 h. The mixture was cooled to RT, filtered and the filter cake washed with AcOEt. The filtrate was concentrated in vacuo, the residue purified by flash chromatography (heptane/AcOEt 1:1 to 1:4) to give (6-diethylcarbamoyimethyl-5-methyl-pyridin-2-yl)-carbamic acid tert-butyl ester (37 mg) as a colorless gum. MS (ESI): 322.4 (MH+).
Step D]: 2-(6-Amino-3-methyl-pyridin-2-yl)-N,N-diethyl-acetamide
This material was obtained in analogy to example 78 step C] from (6-diethylcarbamoylmethyl-5-methyl-pyridin-2-yl)-carbamic acid tert-butyl ester (0.193 and trifluoro-acetic acid (0.69 mL) in CHbCfe (8 mL) as a yellow gum (0.148 g ). MS (ESI): 222.2 (MH*).
Step EJ: 2-[6-(3-Chloro-2-methyl-benzenesulfonylamino)-3-methyl-pyridin-2-yl]-N,N-diethyl-acetamide
This material was obtained in analogy to example 1 from 2-(6-amino-3-methyl-pyridin-2-yl)-N,N-diethyl-acetamide (0.066 g) and 3-chloro-2-methyl-benzenesulfonyl chloride (0.074 g) as an off-white foam (33 mg). MS (ESI"): 408.1 ([M-H]').
Example 81: 2-[6-(3,4-Dichloro-benzenesulfonylamino)-3-methyl-pyridin-2-yl]-N,N-diethyl-acetamide
This material was obtained in analogy to example 1 from 2-(6-amino-3-methyl-pyridin-2-yl)-N,N-diethyl-acetamide (0,066 g) and 3,4-dichloro-benzenesulfonyl chloride (0.081 g) as an off-white foam (55 mg). MS (ESF): 428.1 ([M-H]').

Example 82: 3-Chloro-N-(6-hydroxymethyl-pyridin-2-yl)-2-methyl-benzenesulfonamide
This material was obtained in analogy to example 1 from (6-amino-pyridin-2-yl)-methanol (0.095 g, Asensio, Tetrahedron, 49, 1993, 703) and 3-chloro-2-methyl-benzenesulfonyl chloride (0.172 g) as an white solid (0.115 g). MS (ESF): 311.0 ([M-H]-).
Example 83: 3-Chloro-N-(6-methoxymethyl-pyridin-2-yl)-2-methyl-benzenesulfonamide
This material was obtained in analogy to example 1 from 6-methoxymethyl-pyridin-2-ylamine (0.096 g, Shawcross, J. Heterocycl. Chem., 30, 1993, 563) and 3-chloro-2-methyl-benzenesulfonyl chloride (0.172 g) as an off-white gum (0.158 g). MS (ESI"): 325.1 ([M-H]-)
Example 84: 2,5-Difluoro-N-(6-methoxymethyI-pyridin-2-yl)-benzenesulfonamide
This material was obtained in analogy to example 1 from 6-methoxymethyl-pyridin-2-ylamine (0.096 g) and 2,4-difluoro-benzenesulfonyl chloride (0.162 g) as an off-white gum (0.156 g). MS (ESF): 312.9 ([M-HJO
Example 85: 3-Chloro-N-(6-methoxymethyl-pyridin-2-yl)-4-metbyI-benzenesulfonamide
This material was obtained in analogy to example 1 from 6-methoxymethyl-pyridin-2-ylamine (0.096 g) and 3-chloro-4-methyl-benzenesulfonyl chloride (0.172 g) as an off-white gum (0.169 g). MS (ESP): 325.1 ([M-H]')

Example 86: N-(6-CyclopropylmethoxymethyI-pyridin-2-yl)-2,5-difluoro-benzenesulfonamide
Step A]: N-(6-Cyclopropylmethoxymethyl-pyridin-2-yl)-2,2-dimethyl-propionamide
N-(6-Hydroxymethyl-pyridin-2-yl)-2,2-dimethyl-propionamide (1.04 g,
Papadopoulou,; J. Heterocycl. Chem., 32,1995, 675) in DMF (25 mL) was treated with sodium hydride (0.64 g, 60% suspension in oil), the mixture was then stirred for 1 h at RT, bromomethyl cyclopropane (0.688 g) was added dropwise and stirring was continued for further 1.75 h. The reaction mixture was partitioned between 2 M aqueous KHCOs and AcOEt, the layers were separated, the aqueous layer extracted twice with AcOEt. The combined organic layers were washed with saturated aqueous NaCl and water, dried over Na2SO4, filtered and evaporated. The residue was purified by flash chromatography (heptane/AcOEt 100% to 50%) to N-(6-cyclopropylmethoxymethyl-pyridin-2-yl)-2,2-dimethyl-propionamide (0.884 g) as a yellow oil. MS (ESI): 263.2 (MH4).
StepB]: 6-Cyclopropylmethoxymethyl-pyridin-2-ylamine
N-(6-cyclopropylmethoxymethyl-pyridin-2-yl)-2,2-dimethyl-propionamide (0.884 g) in ethanol (50 mL) was treated at RT with 3M aqueous NaOH (5.62 mL) and then heated at 100 °C for 20 h. The mixture was cooled to RT, partitioned between water and AcOEt. The layers were separated, the organic layer dried over magnesium sulphate, filtered and evaporated in vacuo to give 6-cyclopropylmethoxymethyl-pyridin-2-ylamine (0.566 g) as a light brown liquid. MS (ESI): 179.1 (MH+).
Step C]: N-(6-Cyclopropylmethoxymethyl-pyridin-2-yl)-2,5-difluoro-
benzenesu 1 fonamide
This material was obtained in analogy to example 1 from 6-cyclopropylmethoxymethyl-pyridin-2-ylamine (0.089g) and 2, 5-difluoro-benzenesulfonyl chloride (0.122 g) as an light brown gum (0.175 g). MS (ESF): 353.1 ([M-H]0

Example 87: 5-Fluoro-N-(6-methoxymethyl-pyridin-2-yl)-2-methyl-benzenesu Ifona mid e
This material was obtained in analogy to example 1 from 6-methoxymethyl-pyridin-2-ylamine (0.096 g) and 5-fluoro-2-methyl-benzenesulfonyl chloride (0.159 g) as an light yellow gum (0.16 g). MS (ESF): 309.1 ([M-H]')
Example 88: 2,5-Difluoro-N-(6-hydroxymethyl-pyridin-2-yl)-benzenesulfonamide
This material was obtained in analogy to example 1 from (6-amino-pyridin-2-yl)-methanol (0.1 g) and 2,5-difluoro-benzenesulfonyl chloride (0.17 g) as an light brown amorphous solid MS (ESf): 299.1 ([M-H]")
Example 89: Acetic acid 6-(2,5-difluoro-benzenesuIfonylamino)-pyridin-2-ylmethyl ester
This material was obtained as a second product in the preparation of example 88 (during work-up with AcOEt in the presence of acid) as a red amorphous solid (17 mg). MS(ESO:341.0([M-HP
Example 90: Naphthalene-2-sulfonic acid (6-hydroxymethyl-pyridin-2-yl)-amide
This material was obtained in analogy to example 1 from (6-amino-pyridin-2-yl)-methanol (0.042 g) and naphthalene-2-sulfonyl chloride (0.084 g) as an off-white foam (32 mg g). MS (ESr): 312.9 ([M-H]")
Example 91: 3-Chloro-N-(6-cyclopropylmethoxymethyl-pyridin-2-yl)-4-methyl-benzenesulfonamide

This material was obtained in analogy to example 1 from 6-cyclopropylmethoxymethyl-pyridin-2-ylamine (0.089 g) and 3-chloro-4-methyl-benzenesulfonyl chloride (0.124 g) as a light-yellow gum (0.136 g). MS (ESF): 364.9 ([M-H]')
Example 92: N-(6-Cyclopropylmethoxymethyl-pyridin-2-yl)-5-fluoro-2-methyl-benzenesulfonamide
This material was obtained in analogy to example 1 from 6-cyclopropylmethoxymethyl-pyridin-2-ylamine (0.089 g) and 5-fluoro-2-methyl-benzenesulfonyl chloride (0.15 g) as an off-white gum (0.14 g). MS (ESF): 349.2 ([M-H]')
Example 93: 3-Chloro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yI]-4-methyl-benzenesulfonamide
Step A]: N-[6-(4-Fluoro-benzyloxymethyl)-pyridin-2-yl]-2,2-dimethyl-propionamide
This material was prepared in analogy to example 86 step A] from N-(6-hydroxymethyl-pyridin-2-yl)-2,2*dimethyl- (0.625 g) and 4-fluorobenzyl bromide as a yellow oil (0.83 g). MS (ESI): 317.1 (MFT).
Step B]: 6-(4-Fluoro-benzyloxymethyl)-pyridin-2-ylamine
This material was prepared in analogy to example 86 step B] from N-[6-(4-Fluoro-benzyloxymethyl)-pyridin-2-yl]-2,2-dimethyl-propionamide (0.825 g) and 3M aqueous NaOH (4.35 mL) as a yellow oil (0.596 g). MS (ESI): 233.1 (MH+).
Step C]: 3-Chloro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-4-methyl-
benzenesulfonamide
This material was prepared in analogy to example 1 from 6-(4-fluoro-benzyloxymethyl)-pyridin-2-ylamine (0.058 g) and 3-chloro-4-methyl-benzenesulfonyl chloride (0.062 g) as a light yellow gum (0.09 g). MS (ESF): 419.0. ([M-H]')
Example 94: 3-Chloro-N-[6-(4-fluoro-benzyloxymetbyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide

This material was prepared in analogy to example 1 from 6-(4-fluoro-benzyIoxymethyl)-pyridin-2-ylamine (0.058 g) and 3-chloro-2-methyl-benzenesulfonyl chloride (0.062 g) as a light yellow gum (0.087 g). MS (ESF): 419.0. ([M-H]')
Example 95: 2,5-Difluoro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-benzenesulfonamide
This material was prepared in analogy to example 1 from 6-(4-fluoro-benzyloxymethyl)-pyridin-2-ylamine (0.058 g) and 2,5-difluoro-benzenesulfonyl chloride (0.058 g) as a light yellow gum (0.075 g). MS (ESF): 407.2 ([M-H]')
Example 96: 5-Fluoro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yI]-2-methyI-benzenesulfonamide
This material was prepared in analogy to example 1 from 6-(4-fluoro-benzyloxymethyr)-pyridin-2-ylamine (0.058 g) and 5-fluoro-2-methyl-benzenesulfonyl chloride (0.057 g) as a light yellow gum (0.0476 g). MS (ESr): 403.2 ([M-H]')
Example 97: Piperidine-1-sulfonic acid (6-methoxymethyl-pyridin-2-yl)-amide
This material was obtained in analogy to example 1 from 6-methoxymethyl-pyridin-2-ylamine (0.096 g) and piperidine-1-sulfonyl chloride (0.153 g) as a light yellow gum (0.024 g). MS (ESF): 284.0 ([M-H]0
Example 98: Piperidine-1-sulfonic acid (6-cyclopropylmethoxymethyl-pyridin-2-yl)-amide
This material was obtained in analogy to example 1 from 6-cyclopropylmethoxymethyl-pyridin-2-ylamine (0.089 g) and piperidine-1-sulfonyl chloride (0.11 g) as a light yellow gum (0.054 g). MS (ESP): 324.2 ([M-H]*)

Example 99: 3-Chloro-4-methyl-N-[6-(4-trifluoromethyI-phenoxymethyl)-pyridin-2-yl]-benzenesu!fonamide
Step A]: 2,2-Dimethyl-N-[6-(4-trifluoromethyl-phenoxymethyl)-pyridin-2-yl]-
propionamide
N-(6-Hydroxymethyl-pyridin-2-yl)-2,2-dimethyl-propionamide (0.625 g),
triphenylphophine (0.786 g) and 4-trifluoromethyl-phenol (0.486 g) in toluene was treated at RT under an argon atmosphere with diisopropyl azodicarboxylate (0.67 g). The mixture was stirred for 2 h, partitioned between ice water and AcOEt, the layers were separated, the aqueous layer twice extracted with AcOEt. The combined organic layers were washed with water and saturated aqueous NaCl, dried over MgSO4, filtered and evaporated. The residue was purified by flash chromatography (heptane/AcOEt 100 to 85%) to give 2,2-dimethyl-N-[6-(4-trifluoromethyl-phenoxymethyl)-pyridin-2-yl]-propionamide (0.98 g) as a yellow oil. MS (ESI): 353.2 (MH+).
Step B]: 6-(4-Trifluoromethyl-phenoxymethyl)-pyridin-2-ylamine
This material was prepared in analogy to example 86 step B] from 2,2-Dimethyl-N-[6-(4-trifluoromethyl-phenoxymethyl)-pyridin-2-yl]-propionamide (0.99 g) and 3M aqueous NaOH (4.68 mL) as an off-white crystalline solid (0.647 g). MS (ESI): 269.3
Step C]: 3-Chloro-4-rtiethyl-N-[6-(4-trifluoromethyl-phenoxymethyl)-pyridin-2-yl]-benzenesulfonamide
This material was prepared in analogy to example 1 from 6-(4-trifluoromethyl-phenoxymethyl)-pyridin-2-ylamine (0.08 g) and 3-chloro-4-methyl-benzenesulfonyl chloride (0.074 g) as an off-white solid (0.105 g). MS (ESF): 455.2 ([M-H]").
Example 100: 3-Chloro-2-methyl-N-[6-(4-trifluoromethyl-phenoxymethyI)-pyridin-2-yI]-benzenesulfonamide

This material was prepared in analogy to example 1 from 6-(4-trifluoromethyl-phenoxymethyl)-pyridin-2-ylamine (0.08 g) and 3-chloro-2-methyl-benzenesulfonyl chloride (0.074 g) as an off-white solid (0.113 g). MS (ESF): 455.2 ([M-H]').
Example 101: 2,5-Difluoro-N-|6-(4-trifluoromethyl-phenoxymethyl)-pyridin-2-yl)-benzenesulfonarnide
This material was prepared in analogy to example 1 from 6-(4-trifluoromethyl-phenoxymethyl)-pyridin-2-ylamine (0.08 g) and 2,5-difluoro-benzenesulfonyl chloride (0.07 g) as a light yellow solid (0.086 g). MS (ESF): 443.0 ([M-H]')
Example 102: 5-Fluoro-2-methyl-N-[6-(4-trifluoromethyl-phenoxymethyI)-pyridin-2-ylj-benzenesulfonamide
This material was prepared in analogy to example 1 from 6-(4-trifluoromethyl-phenoxymethyl)-pyridin-2-ylamine (0.08 g) and 5-fluoro-2-methyl-benzenesulfonyl chloride (0.07 g) as a light yellow solid (0.1 g). MS (ESF): 439.1 ([M-H]')
Example 103: 3-ChIoro-N-(6-cyclopropylmethoxymethyl-pyridin-2-yl)-2-methyl-benzenesulfonamide
This material was obtained in analogy to example 1 from 6-cyclopropylmethoxymethyl-pyridin-2-ylamine (0.09 g) and 3-chloro-2-methyl-benzenesulfonyl chloride (0.13g) as an off-white gum (0.135 g). MS (ESF): 365.0
Example 104: 3,4-Dichloro-N-(6-cyclopropylmethoxymethyl-pyridin-2-yl)-benzenesulfonamide
This material was obtained in analogy to example 1 from 6-cyclopropylmethoxymethyl-pyridin-2-ylamine (0.09 g) and 3,4-dichloro-benzenesulfonyl chloride (0.143g) as an off-white gum (0.143 g). MS (ESF): 385.0 ([M-H]')

Example 105: 4-Fluoro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-benzenesulfonamide
This material was prepared in analogy to example 1 from 6-(4-fluoro-benzyloxymethyl)-pyridin-2-ylamine (0.058 g) and 4-fluoro-benzenesulfonyl chloride (0.054 g) as a light yellow gum (0.08 g). MS (ESF): 389.1 ([M-H]')
Example 106: N-[6-(4-Fluoro-benzyloxymethyl)-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide
This material was prepared in analogy to example 1 from 6-(4-fluoro-benzyloxymethyl)-pyridin-2-ylamine (0.058 g) and 3-(trifluoromethyl)-benzenesulfonyl chloride (0.067 g) as a light yellow gum (O.OSg). MS (ESF): 439.1 ([M-H]')
Example 107: 3-Chloro-N-(5-cyclopropylmethoxymethyl-pyridin-2-yl)-2-methyl-benzenesulfonamide
Step A]: N-(5-Formyl-pyridin-2-yl)-2,2-dimethyl-propionamide
A solution of N-(5-Bromo-pyridin-2-yl)-2,2-dimethyl-propionamide (8.7 g, Kelly, Tetrahedron Lett., 32, 1991, 4263) in THF (200 mL) was cooled to -70°C under an argon atmosphere and treated dropwise over 30 minutes with n-butyllithium (45.78 mL, 1.6 M in hexane, Acros), The mixture was stirred 1 h at -70°C and then treated dropwise (over 10 minutes, at -70°C) with a mixture of N,N-dimethylformamide (5.25 mL) in THF (5 mL), and stirring was continued for further 30 minutes. The reaction mixture was then poured into 2M aqueous KHCOs (1.2 L), tert-butyl methyl ether (1.2 L) was added, and after stirring for 20 minutes, the layers were separated, the organic layer extracted twice with tert-butyl methyl ether (total volume 0.3 L). The combined organic layers were dried over sodim sulphate, filtered and evaporated in vacuo to give N-(5-formyl-pyridin-2-yl)-2,2-dimethyl-propionamide (7 g) as an yellow oil that was used directly in the next step.
StepB]: N-(5-Hydroxymethyl-pyridin-2-yl)-2,2-dimethyl-propionamide

N-(5-formyl-pyridin-2-yl)-2,2-dimethyl-propionamide (6.96 g) under an argon atmosphere in MeOH (120 mL) was cooled to 0°C and then treated portionwise with sodium borohydride (1.289 g). The cooling bath was removed, stirring was continued for 30 minutes and the reaction mixture was partitioned between half-saturated aqueous NUjCl and AcOEt. The layers were separated, the organic layer dried over sodium sulphate, filtered and concentrated in vacuo. The residue was purified by flash, chromatography (heptane/AcOEt 1:1 to 1:2) to give N-(5-hydroxymethyI-pyridin-2-yl)-2,2-dimethyl-propionamide (3.4 g) as a crystalline white solid. MS (ESI): 209.2 (MH+).
StepC]: N-(5-Cyclopropylmethoxymethyl-pyridin-2-yl)-2,2-dimethyl-propionamide
This material was prepared in analogy to example 86 step A] from N-(5-hydroxymethyl-pyridin-2-yl)-2,2-dimethyl-propionamide (1.04 g) and bromomethyl cyclopropane (0.813 g) as a light yellow oil (0.87 g). MS (ESI): 263.1. (MH+).
Step D]: 5-Cyclopropylmethoxymethyl-pyridin-2-ylamine
This material was prepared in analogy to example 86 step B] from N-(5-cyclopropylmethoxymethyl-pyridin-2-yl)-2,2-dimethyl-propionamide (0.87 g) and 3M aqueous NaOH (5.54 mL) as a yellow solid (0.527 g), MS (ESI): 179.1 (MH+).
Step E]: 3-Chloro-N-(5-cyclopropylmethoxymethyl-pyridin-2-yl)-2-methyl-
benzenesulfonamide
This material was prepared in analogy to example 1 from 5-cyclopropylmethoxymethyl-pyridin-2-ylamine (0.089 g) and 3-chloro-2-methyl-benzenesulfonyl chloride (0.142 g) as a light yellow gum (0.152 g). MS (ESF): 365.0 ([M-H]')
Example 108: 4 N-(5-Cyclopropylmethoxymethyl-pyridin-2-yl)-2,5-difluoro-benzenesulfonamide

This material was prepared in analogy to example 1 from 5-cyclopropylmethoxymethyl-pyridin-2-ylamine (0.089 g) and 2,5-difluro-benzenesulfonyl chloride (0.117 g) as an off-white solid (0.119 g). MS (ESF): 353.1 ([M-H]')
Example 109: 4-Chloro-N-(5-cyclopropylmethoxymethyl-pyridin-2-yl)-3-methyl-benzenesulfonamide
This material was prepared in analogy to example 1 from 5-cyclopropylmethoxymethyl-pyridin-2-ylamine (0.089 g) and 3-chloro-4-methyl-benzenesulfonyl chloride (0.124 g) as an off-white solid (0.128 g). MS (ESF): 365.0 ([M-H]')
Example 110: 4 N-(5-Cyclopropylmethoxymethyl-pyridin-2-yl)-5-fluoro-2-
methyl-benzenesulfonamide
This material was prepared in analogy to example 1 from 5-cyclopropylmethoxymethyl-pyridin-2-ylamine (0.089 g) and 5-fluoro-2-methyl-benzenesulfonyl chloride (0.115 g) as an off-white solid (0.119 g). MS (ESF): 349.3 ([M-H]0
Example 111: Piperidine-1-sulfonic acid (5-cycIopropylmethoxymethyl-pyridin-2-yl)-amide
This material was prepared in analogy to example 1 from 5-cyclopropylmethoxymethyl-pyridin-2-ylamine (0.089 g) and piperidine-1-sulfonyl chloride (0.142 g) as a light yellow gum (0.027 g). MS (ESF): 324.2 ([M-H]')
Example 112: 3-ChIoro-N-(5-cyclopropylmethoxymethyI-6-methyl-pyridin-2-yl)-2-methyl-benzenesulfonamide
Step A]: N-(5-Formyl-6-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide
This material was prepared in analogy to example 107 step A] from N-(5-bromo-6-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide, 7.05 g - obtained via standard acylation of 5-bromo-6-methyl-pyridin-2-ylamine with 2,2-dimethyl-propionyl chloride in CH2C!2, with triethylamine as base, as viscous brown oil, MS (ESI): 271.2 (MH+) -

butyllithium (34.94 mL, 1.6 M in hexane, Agros) and N,N-dimethylformamide (4 mL) as an amorphous light brown solid (5.7 g). MS (El): 220.1 (M+)
Step B]: N-(5-Hydroxymethyl-6-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide
This material was prepared in analogy to to example 107 step B] from N-(5-formyl-6-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide (5.9 g) and sodium borohydride (1.037 g) as a light yellow solid (1.41 g). MS (ESI): 223.2 (MH*).
Step C]: N-(5-Cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-2,2-dimethyl-
propionamide
This material was prepared in analogy to example 86 step A] from N-(5-Hydroxymethyl-6-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide (0.445 g) and bromomethyl cyclopropane (0.275 g) as a light yellow oil (0.357g). MS (ESI): 277.2
Step D]: 5-Cyclopropylmethoxymethyl-6-methyl-pyridin-2-ylamine
This material was prepared in analogy to example 86 step B] from N-(5-cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide (0.357 g) and 3M aqueous NaOH (2.68 mL) as a dark red oil (0.163 g). MS (El): 192.2 (M+).
Step E]; 3-Chloro-N-(5-cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-2-methyl-benzenesu Ifonam ide
This material was prepared in analogy to example 1 from 5-cyclopropylmethoxymethyl-6-methyl-pyridin-2-ylamine (0.053 g) and 3-chloro-2-methyl-benzenesulfonyl chloride (0.058 g) as a light brown solid (0.046 g). MS (ESF): 379.1 ([M-H]')

Example 113: N-(5-Cyclopropylmethoxy methyl-6-methyl-py ridin-2-yl)-2,5-difluoro-benzenesulfonamide
This material was prepared in analogy to example 1 from 5-cyclopropylmethoxymethyl-6-methyI-pyridin-2-ylamine (0.053 g) and 2,5-difiuoro-benzenesulfonyl chloride (0.059 g) as a light yellow solid (0.063 g). MS (ESF): 367.0 ([M-H]-)
Example 114: N-(5-Cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-5-fluoro-2-methyl-benzenesulfonamide
This material was prepared in analogy to example 1 from 5-cyclopropylmethoxymethyl-6-methyI-pyridin-2-ylamine (0.053 g) and 5-fluoro-2-methyl-benzenesulfonyl chloride (0.058 g) as a light yellow solid (0.063 g). MS (ESF): 363.3 ([M-H]')
Example 115: N-(5-Methoxymethyl-6-methyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide
Step A]: N-(5-Methoxymethyl-6-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide
This material was prepared in analogy to example 86 step A] from N-(5-hydroxymethyl-6-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide (0.6 g, product of example 112 step B]) and iodomethane (0.421 g) as a white solid (0.4 g). MS (ESI): 237.2 (MH+).
Step B]: 5-Methoxymethyl-6-methyl-pyridin-2-ylamine
This material was prepared in analogy to example 86 step B] from N-(5-methoxymethyl-6-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide (0.4 g) and 3M aqueous NaOH (2.68 mL) as a crystalline orange solid (0.174 g). MS (El): 152.2 (M+).
Step C]: N-(5-Methoxymethyl-6-methyl-pyridin-2-yl)-3-trifluoromethyl-
benzenesulfonamide

This material was prepared in analogy to example 1 from 5-methoxymethyl-6-methyl-pyridin-2-ylamine (0.058 g) and 3-(trifluoromethyl)-benzenesulfonyl chloride (0.103 g) as a light yellow gum (0.1 g). MS (ESI'): 359.0
Example 116: 3-Chloro-N-(5-methoxymethyl-6-methyl-pyridin-2-yl)-2-methyI-benzenesulfonamide
This material was prepared in analogy to example 1 from 5-methoxymethyl-6-methyl-pyridin-2-ylamine (0.058 g) and 3-chloro-2-methyl-benzenesulfonyl chloride (0.094 g) as an off-white foam (0.093 g). MS (ESF): 339.0 ([M-H]')
Example 117: N-[5-(4-Fluoro-benzyloxymethyI)-6-methyl-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide
Step A]: N-[5-(4-Fluoro-benzyloxymethyl)-6-methyl-pyridin-2-yl]-2,2-dimethyl-propionamide
This material was prepared in analogy to example 86 step A] from N-(5-hydroxymethyl-6-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide (0.6 g, product of example 112 step B]) and 4-fluorobenzyl bromide (0.56 g) as an orange solid (0.8 g). MS (ESI): 231.3 (MH*).
Step B]: 5-(4-Fluoro-benzyloxymethyl)-6-methyl-pyridin-2-ylamine
This material was prepared in analogy to example 86 step B] from N-[5-(4-Fluoro-benzyloxymethyl)-6-methyl-pyridin-2-yl]-2,2-dimethyl-propionamide (0.78 g) and 3M aqueous NaOH (3.93 mL) as an amorphous orange solid (0.58 g). MS (ESI): 247.2
Step C]: N-[5-(4-Fluoro-benzyloxymethyl)-6-methyl-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide
This material was prepared in analogy to example 1 from 5-(4-fluoro-benzyloxymethyl)-6-methyl-pyridin-2-ylamine (0.08 g) and 3-(trifluoromethyl)-

benzenesulfonyl chloride (0.087 g) as an amorphous orange solid (0.1 g). MS (ESI~): 453.2 ([M-H]")
Example 118: 3-Chloro-N-[5-(4-fluoro-benzyloxymethyl)-6-methyl-pyridin-2-yl]-2-methyl-benzenesulfonamide
This material was prepared in analogy to example 1 from 5-(4-fluoro-benzyloxymethyl)-6-methyl-pyridin-2-ylamine (0.08 g) and 3-chloro-2-methyl-benzenesulfonyl chloride (0.08 g) as an amorphous light yellow solid (0.067 g). MS (ESI'): 433.1 ([M-H]')
Example 119: N-(5-Ethoxy methyl-6-methyI-pyridin-2-yl)-3-trifluoromethy I-benzenesulfonamide
Step A]: N-(5-Ethoxymethyl-6-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide
This material was prepared in analogy to example 86 step A] from N-(5-hydroxymethyl-6-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide (0.445 g, product of example 112 step B]) and iodoethane (0.34 g) as a light yellow oil (0.32 g). MS (ESI): 251.2(MH+).
Step B]: 5-Ethoxymethyl-6-methyl-pyridin-2-ylamine
This material was prepared in analogy to example 86 step B] from N-(5-ethoxymethyl-6-methyI-pyridin-2-yl)-2,2-dimethyl-propionamide (0.32 g) and 3M aqueous NaOH (2.62 mL) as a yellow oil (0.28 g) that was used directly in the next step.
Step C]: N-(5-Ethoxymethyl-6-methyl-pyridin-2-yl)-3-trifluoromethyl-
benzenesulfonamide
This material was prepared in analogy to example 1 from 5-Ethoxymethyl-6-methyl-pyridin-2-ylamine (0.066 g) and 3-(trifluoromethyl)-benzenesulfonyl chloride (0.108 g) as a light yellow solid (0.115 g). MS (ESF): 373.1 ([M-H]")

Example 120: 3-Chloro-2-methyl-N-{6-[(methyl-propyl-amino)-methyl]-pyridin-2-yl}-benzenesulfonamide
Step A]: N-(6-chloromethyl-pyridin-2-yl)-2,2-dimethyl-propionamide
N-(6-Hydroxymethyl-pyridin-2-yl)-2,2-dimethyl-propionamide (2.03 g) in CH2C12 (75 mL) was treated at RT with thionyl chloride (1.785 mL) and then heated to reflux for 1.5 h. The reaction mixture was cooled to RT and partitioned between water and AcOEt, the layers were separated, the organic layer dried over MgSCU, filtered and evaporated to give N-(6-chloromethyl-pyridin-2-yl)-2,2-dimethyl-propionamide (0.66 g) as a brown liquid. MS (ESI): 227.2 (MH+).
Step B]: 2,2-Dimethyl-N-{6-[(methyl-propyl-amino)-methyl]-pyridin-2-yl}-
propionamide
N-(6-chloromethyl-pyridin-2-yl)-2,2-dimethyl-propionamide (0.66 g), methyl-propyl-amine (0.33 mL), KHCOs (0.32 g) and a catalytic amount of potassium iodide in acetone (10 mL) were heated to reflux for 6 h. The reaction mixture was cooled to RT and partitioned between water and AcOEt, the layers were separated, the organic layer dried over MgSO4, filtered and evaporated to give 2,2-dimethyl-N-{6-[(methyl-propyl-amino)-methyl]-pyridin-2-yl}-propionamide (0.75 g) as a brown oil. MS (ESI): 264.3 (MH*).
Step C]: 6-[(Methyl-propyl-amino)-methyl]-pyridin-2-ylamine
This material was prepared in analogy to example 86 step B] from 2,2-dimethyl-N-{6-[(methyl-propyl-amino)-methyl]-pyridin-2-yl}-propionamide (0.755 g) and 3M aqueous NaOH (5.73 mL) as a brown liquid (0.53 g). MS (ESI): 180.2 (MH+).
Step D]: 3-Chloro-2-methyl-N-{6-[(methyl-propyl-amino)-methyl]-pyridin-2-yl}-benzenesulfonamide

This material was prepared in analogy to example 1 from 6-[(methyl-propyl-amino)-methyl]-pyridin-2-ylamine (0.072 g) and 3-chloro-2-methyl-benzenesulfonyl chloride (0.09 g), obtained as sodium salt, as a brown gum (0.06 g). MS (ESI'): 366.1 ([M-H]")
Example 121: 5-Fluoro-2-methyl-N-{6-[(methyl-propyl-amino)-methyI]-pyridin-2-yl}-benzenesulfonamide
This material was prepared in analogy to example 1 from 6-[(methyl-propyl-amino)-methyl]-pyridin-2-ylamine (0.072 g) and 2-methyl-5-fluoro-benzenesulfonyl chloride (0.09 g), obtained as sodium salt, as a brown gum (0.058 g). MS (ESF): 350.3 ([M-H]0
Example 122: 3-ChIoro-N-(5-ethoxymethyI-6-methyl-pyridin-2-yl)-2-methyl-benzenesulfonamide
This material was prepared in analogy to example 1 from 5-ethoxymethyl-6-methyl-pyridin-2-ylamine (0.066 g) and 3-chloro-2-methyl-benzenesulfonyl chloride (0.099 g) as an off-white solid (0.08 g). MS (ESF): 351.3
Example 123: 3-ChIoro-N-(6-cyclopropyl-pyridin-2-yl)-2-methyl-benzenesulfonamide
Step A]: 6-Cyc lopropyl-pyridin-2-ylam ine
To a scalable vial under nitrogen was added 2-amino-6-bromo-pyridine (1.6 g), cyclopropyl boronic acid (1,03 g) (prepared according to Wallace et al. Tetrahedron Lett. 2002, 43, 6987-6990), potassium phosphate (6.87 g), tricyclohexylphosphine (0.260 g) followed by water (2 mL) and toluene (40 mL). Pd(OAc)2 (0.104 g) was then added and the vial was sealed and heated at 100° C over 16 hours. The reaction was then allowed to cool to ambient temperature and diluted with water and ethyl acetate. The phases were separated and the aqueous phase was extracted with more ethyl acetate (3x). The combined phases were washed with brine and dried over sodium sulfate. Filtration and evaporation of the volatiles afforded a crude residue which was purified via ISCO Combiflash chromatography using ethyl acetate/heptane as the eluent to give the desired 6-cyclopropyl-pyridin-2-ylamine as yellow solid (0.450 g).

StepB]: 3-Chloro-N-(6-cyclopropyl-pyridin-2-yl)-2-methyl-benzenesulfonamide
This material was obtained in analogy to example 1 from 6-cyclopropyl-pyridin-2-ylamine (0.08 g) and 3-chloro-2-methylbenzenesulfonylchoride (0.134 g) as a colorless amorphous solid. (0.075 g). MS (ESI4): 323.1 ([M+H]+).
Example 124: Naphthalene-1-sulfonic acid (6-cyclopropyl-pyridin-2-yl)-amide
This material was obtained in analogy to example 1 from 6-cyclopropyl-pyridin-2-ylamine (0.1 g) and naphthaline-1-sulfonylchloride (0.169 g) as a light yellow amorphous gum. (0.03 g). MS (ESI*): 325.3 ([M+H]+).
Example 125: 4-Chloro-N-(6-cyclopropyl-pyridin-2-yl)-2,5-dimethyl-benzenesulfonamide
This material was obtained in analogy to example 1 from 6-cyclopropyl-pyridin-2-ylamine (0.1 g) and 4-chloro-2,5-dimethylbenzenesulfonylchloride (0.180 g) as an off-white amorphous solid (0.023 g). MS (ESf): 337.1 ([M+H]+).
Example 126: 4-Chloro-N-(6-cyclopropyl-pyridin-2-yl)-3-methyI-benzenesulfonamide
This material was obtained in analogy to example 1 from 6-cyclopropyl-pyridin-2-ylamine (0.1 g) and 3-chloro-4-methylbenzenesulfonylchloride (0.168 g) as waxy yellow solid (0.039 g). MS (ESI*): 323.3 ([M+H]+).
Example 127: N-(6-CyclopropyI-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide

This material was obtained in analogy to example 1 from 6-cyclopropyl-pyridin-2-ylamine (0.1 g) and 3-(trifluoromethyl)benzenesulfonylchloride (0.182 g) as a light yellow gum (0.060 g). MS (ESI*): 343.1 ([M+H]*).
Example 128: 2,4-Dichloro-N-(6-cyclopropyl-pyridin-2-yl)-5-methyl-benzenesulfonamide
This material was obtained in analogy to example 1 from 6-cyclopropyl-pyridin-2-ylamine (0.1 g) and 2,4-dichloro-5-methylbenzenesulfonylchloride (0.193 g) as a light yellow gum(0.047 g). MS (ESI*): 357.1 ([M+Hf).
Example 129: Naphthalene-2-sulfonic acid (6-cycIopropyI-pyridin-2-yl)-amide
This material was obtained in analogy to example 1 from 6-cyclopropyl-pyridin-2-ylamine (0.1 g) and naphthaline-2-sulfonylchloride (0.169 g) as a light yellow gum (0.150 g). MS (ESI+): 325.3 ([M+H]+).
Example 130: N-(5-Cyclopropylmethoxymethyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide
This material was prepared in analogy to example 1 from 5-cyclopropylmethoxymethyl-pyridin-2-ylamine (0.051 g) and 3-(trifluromethyl)-benzenesulfonyl chloride (0.077 g) as a crystalline white solid (0.062 g). MS (ESF): 385.0 ([M-H]')
Example 131: N-(5-Ethoxymethyl-6-methyl-pyridin-2-yl)-3,5-bis-trifluoromethyl-benzenesulfonamide
This material was prepared in analogy to example 1 from 5-ethoxymethyl-6-methyl-pyridin-2-ylamine (0.07 g) and 3,5-di(trifluoromethyl)-benzenesulfonyl chloride (0.145 g) as an off-white solid (0.032 g). MS (ESF): 441.1 ([M-H]0

Example 132: 4-Chloro-N-(5-ethoxymethyl-6-methyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide
This material was prepared in analogy to example 1 from 5-ethoxymethyl-6-methyI-pyridin-2-ylamine (0.07 g) and 4-chloro-3-(trifluoromethyl)- benzenesulfonyl chloride (0.129 g) as a yellow gum (0.068 g). MS (ESF): 407.2 ([M-H]")
Example 133: 4-Chloro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide
This material was prepared in analogy to example 1 from 6-(4-fluoro-benzyloxymethyl)-pyridin-2-ylamine (0.058 g) and 4-chloro-3-(trifluoromethyl)-benzenesulfonyl chloride (0.077 g) as a light yellow gum (0.084 g). MS (ESF): 472.8 ([M-H]-)
Example 134: 4-Chloro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-2,5-dimethyl-benzenesulfonamide
This material was prepared in analogy to example 1 from 6-(4-fluoro-benzyloxymethyl)-pyridin-2-ylamine (0.058 g) and 4-chloro-2,5-dimethyl-benzenesulfonyl chloride (0.066 g) as a light yellow gum (0.089 g). MS (ESI~): 433.2. ([M-HD
Example 135: 3-Trifluoromethyl-N-[6-(4-trifluoromethyl-phenoxymethyl)-pyridin-2-yl]-benzenesulfonamide
This material was prepared in analogy to example 1 from 6-(4-trifluoromethyl-phenoxymethyl)-pyridin-2-ylamine (0.08 g) and 3-(trifluoromethyl)-benzenesulfonyl chloride (0.081 g) as a light yellow gum (0.114 g). MS (ESF): 475.0 ([M-H]').
Example 136: N-[5-(2-Fluoro-ethoxymethyl)-6-methyl-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide

Step A]: N-[5-(2-Fluoro-ethoxymethyl)-6-methyl-pyridin-2-yl]-2,2-dimethyl-
propionamide
This material was prepared in analogy to example 86 step A] from N-(5-hydroxymethyl-6-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide (0.556 g, product of example 112 step B]) and l-bromo-2-fluoro-ethane (0.475 g) as a light yellow gum (0.115 g). MS (ESI): 269.3 (MH+).
Step B]: 5-(2-Fluoro-ethoxymethyl)-6-methyl-pyridin-2-ylamine
This material was prepared in analogy to example 86 step B] from N-[5-(2-Fluoro-ethoxymethyl)-6-methyl-pyridin-2-yl]-2,2-dimethyl-propionamide (0.165 g) and 3M aqueous NaOH (1.23 mL) as an gum (0.174 g) that was used directly in the next step.
Step C]: N-[5-(2-Fluoro-ethoxymethyl)-6-methyl-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide
This material was prepared in analogy to example 1 from 5-(2-fluoro-ethoxymethyl)-6-methyl-pyridin-2-ylamine (0.05 g) and 3-(trifluoromethyl)-benzenesulfonyl chloride (0.073 g) as a light yellow gum (39 mg g). MS (ESI'): 391.2 ([M-H]')
Example 137: 3-Chloro-N-(5-cyclopropylmethoxymethyI-pyridin-2-yI)-benzenesulfonamide
This material was prepared in analogy to example 1 from 5-cyclopropylmethoxymethyl-pyridin-2-ylamine (0.06 g) and 3-chloro-benzenesulfonyl chloride (0.078 g) as an amorphous off-white solid (0.059 g). MS (ESI'): 351.1 ([M-HD
Example 138: 2,4-Dichloro-N-(5-cyclopropylmethoxymethyI-pyridin-2-yl)-6-methyl-benzenesulfonamide

This material was prepared in analogy to example 1 from 5-cyclopropylmethoxymethyI-pyridin-2-ylamine (0.06 g) and 2,4-dichloro-6-methyl-benzenesulfonyl chloride (0.096 g) as an off-white solid (0.069 g). MS (ESF): 399.1 ([M-H]")
Example 139: 2,4-Dichloro-N-(5-cyclopropylmethoxyraethyl-pyridin-2-yI)-6-methyl-benzenesulfonamide
This material was prepared in analogy to example 1 from 5-cyclopropylmethoxymethyl-pyridin-2-ylamine (0.06 g) and 4-fluoro-3-(trifluoromethyl)-benzenesulfonyl chloride (0.097 g) as a crystalline white solid (0.066 g). MS (ESF): 403.2 ([M-H]")
Example 140: 3-Chloro-N-(5-cyclopropyImethoxymethyl-6-methyl-pyridin-2-yl)-benzenesulfonamide
This material was prepared in analogy to example 1 from 5-cyclopropylmethoxymethyl-6-methyl-pyridin-2-ylamine (0.06 g) and 3-chloro-6-methyl-benzenesulfonyl chloride (0.072 g) as a light yellow solid (0.07 g). MS (ESF): 364.9 ([M-HD
Example 141: 2,4-Dichloro-N-(5-cyclopropylmethoxymethyl-6-methyl-pyridin-2-yI)-6-methyl-benzenesulfonamide
This material was prepared in analogy to example 1 from 5-cyclopropylmethoxymethyl-6-methyl-pyridin-2-ylamine (0.06 g) and 2,4-dichloro-6-methyl-benzenesulfonyl chloride (0.089 g) as an amorphous light yellow solid (0.058 g). MS (ESF): 413.1 ([M-H]-)
Example 142: 2,4-Dichloro-N-(5-cyclopropylmethoxymethyl-6-methyl-pyridin-2-yI)-6-methyl-benzenesulfonamide
This material was prepared in analogy to example 1 from 5-cyclopropylmethoxymethyl-6-methyl-pyridin-2-ylamine (0.06 g) and 3-(trifluoromethyl)-benzenesulfonyl chloride (0.084 g) as a light yellow solid. MS (ESI): 401.4 ([MHf)

Example 143: 2,4-Difluoro-N-[6-(3-fluoro-benzyloxymethyl)-pyridin-2-yl]-benzenesulfonamide
Step A]: N-[6-(3-fluoro-benzyloxymethyl)-pyridin-2-yl]-2,2-dimethyl-propionamide
This material was prepared in analogy to example 86 step A] from N-(6-hydroxymethyl-pyridin-2-yl)-2,2-dimethyl-propionamide (0.73 g) and 3-fluorobenzyl bromide as a yellow solid(0.66 g). MS (ESI): 317.1 (MH+).
Step B]: 6-(3-Fluoro-benzyloxymethyl)-pyridin-2-ylamine
This material was prepared in analogy to example 86 step B] from N-[6-(3-fluoro-benzyloxymethyl)-pyridin-2-yl]-2,2-dimethyl-propionamide (0.663 g) and 3M aqueous NaOH (4.19 mL) as a brown liquid (0.596 g). MS (ESI): 233.2 (MH+).
Step C]: 2,4-Difluoro-N-[6-(3-fluoro-benzyloxymethyl)-pyridin-2-yl]-
benzenesu 1 fonam ide
This material was prepared in analogy to example 1 from 6-(3-fiuoro-benzyloxymethyl)-pyridin-2-ylamine (0.06 g) and 2,4-difluoro-benzenesulfonyl chloride (0.06 g) as a yellow solid(0.07 g). MS (ESF): 407.2 ([M-H]').
Example 144: 3-Chloro-N-[6-(3-fluoro-benzyloxymethyl)-pyridin-2-yl]-benzenesulfonamide
This material was prepared in analogy to example 1 from 6-(3-fiuoro-benzyloxymethyl)-pyridin-2-ylamine (0.06 g) and 3-chloro-benzenesulfonyl chloride (0.06 g) as a yellow gum (0.07 g). MS (ESI'): 405.1 ([M-H]').
Example 145: 2,4-Dichloro-N-[6-(3-fluoro-benzyloxymethyl)-pyridin-2-yl]-6-methyl-benzenesulfonamide

This material was prepared in analogy to example 1 from 6-(3-fluoro-benzyloxymethyl)-pyridin-2-ylamine (0.06 g) and 2,4-dichloro-6methyl-benzenesulfonyl chloride (0,074 g) as a yellow solid (0.12 g). MS (ESI"): 453.1 ([M-H]-).
Example 146: 2,4-Difluoro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-benzenesulfonamide
This material was prepared in analogy to example 1 from 6-(4-fluoro-
benzyloxymethyl)-pyridin-2-ylamine (0.07 g) and 2,4-dichloro-6-methyl-
benzenesulfonyl chloride (0.07 g) as a light yellow solid (0.104 g). MS (ESI"): 407.2 ([M-H]").
Example 147: 3-Chloro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-benzenesulfonamide
This material was prepared in analogy to example 1 from 6-(4-fluoro-benzyloxymethyl)-pyridin-2-ylamine (0.07 g) and 3-chloro-benzenesulfonyl chloride (0.07 g) as a light yellow gum (0.059 g). MS (ESI"): 405.2 ([M-H]").
Example 148: 2,4-Dichloro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-6-methyl-benzenesulfonamide
This material was prepared in analogy to example 1 from 6-(4-fluoro-benzyloxymethyl)-pyridin-2-ylamine (0.07 g) and 2,4-dichloro-6-methyl-benzenesulfonyl chloride (0.086 g) as a light yellow solid (0.11 g). MS (ESF): 453.1 ([M-H]-).
Example 149: N-(5-CyclopropyImethoxymethyl-6-methyl-pyridin-2-yl)-5-fluoro-2-methyI-benzenesulfonamide

This material was prepared in analogy to example 1 from 5-cyclopropylmethoxymethyl-6-methyl-pyridin-2-ylamine (0.06 g) and 4-fluoro-3-(trifluoromethyl)-benzenesulfonyl chloride (0.12 g) as a light yellow solid (0.12g). MS (ESI'): 417.0 ([M-H]')
Example 150: 4-Fluoro-N-[6-(3-fluoro-benzyloxyraethyl)-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide
This material was prepared in analogy to example 1 from 6-(3-fluoro-benzyloxymethyl)-pyridin-2-ylamine (0.06 g) and 4-fluoro-3-(trifluoromethyl)-benzenesulfonyl chloride (0.075 g) as a light yellow solid (0.1 g). MS (ESI"): 457.2 ([M-H]-).
Example 151: 4-Fluoro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide
This material was prepared in analogy to example 1 from 6-(4-fluoro-benzyloxymethyl)-pyridin-2-ylamine (0.07 g) and 4-fluoro-3-(trifluoromethyl)-benzenesulfonyl chloride (0.087 g) as a light yellow gum (0.11 g). MS (ESF): 457.2 ([M-H]-).
Example 152: N-[6-(4-Fluoro-benzyloxymethyI)-pyridin-2-yl]-3-trifluoromethoxy-benzenesulfonamide
This material was prepared in analogy to example 1 from 6-(4-fluoro-benzyloxymethyl)-pyridin-2-ylamine (0.07 g) and 3-(trifluoromethoxy)-benzenesulfonyl chloride (0.086 g) as a light yellow gum (0.097 g). MS (ESF): 455.2 ([M-H]-).
Example 153: N-(6-Methoxymethyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide

This material was obtained in analogy to example 1 from 6-methoxymethyl-pyridin-2-ylamine (0.076 g) and 3-(trifluormethyl)-benzenesulfonyl chloride (0.148 g) as a light yellow gum (0.13 g). MS (ESF): 345.1. ([M-H]')
Example 154: 2,4-Dichloro-N-(6-methoxymethyl-pyridin-2-yl)-6-methyI-benzenesulfonamide
This material was obtained in analogy to example 1 from 6-methoxymethyl-pyridin-2-ylamine (0.076 g) and 2,4-dichloro-6-mehyl-benzenesulfonyl chloride (0.157 g) as an off-white solid (0.138 g). MS (ESP): 358.9. ([M-H]')
Example 155: 3-ChIoro-N-(6-methoxymethyl-pyridin-2-yl)-benzenesulfonamide
This material was obtained in analogy to example 1 from 6-methoxymethyl-pyridin-2-ylamine (0.076 g) and 3-chloro-benzenesulfonyl chloride (0.128 g) as an light yellow gum (0.147 g). MS (ESI"): 311.0 ([M-H]")
Example 156: 3-Trifluoromethyl-N-[6-(3rJ,3-trinuoro-propoxymethyl)-pyridin-2-yl|-benzenesulfonatnide
Step Aj: 2,2-Dimethyl-N-[6-(3,3,3-trifluoro-propoxymethyl)-pyridin-2-yl]-
propionamide
3,3,3-Trifluoro-propan-l-ol (0.214 g) in THF (8 tnL) was treated under an argon atmosphere with sodium hydride (0,1 g, 60% suspension in oil) and stirred for 1 h at RT. N-(6-chioromethyl-pyridin-2-yl)-2,2-dimethyl-propionamide, 0.142 g, product of example 120 step A ], was added and the mixture was heated at 85°C for 2.5 h. The reaction mixture was cooled, partitioned between ice water and AcOEt, the layers were separated, the organic layer dried over Na2SO4, filtered and evaporated to give 2,2-dimethyl-N-[6-(3,3,3-trifluoro-propoxymethyl)-pyridin-2-yl]-propionamide (0.21 g) as a light brown oil. MS (ESI): 305.3 (MH*).
Step B]: 6-(3,3s3-Trifluoro-propoxymethyl)-pvridin-2-ylamine

This material was prepared in analogy to example 86 step B] from 2,2-dimethyl-N-[6-(3,3,3-trifluoro-propoxymethyl)-pyridin-2-yl]-propionamide (0.2 g) and 3M aqueous NaOH (1.31 mL) as a brown oil (0.159 g). MS (ESI): 221.2 (MH*).
Step C]: 3-Trifluoromethyl-N-[6-(3,3,3-trifluoro-propoxymethyl)-pyridin-2-yl]-benzenesu Ifonam ide
This material was prepared in analogy to example 1 from 6-(3,3,3-Trifluoro-propoxymethyl)-pyridin-2-ylamine (0.075 g) and 3-(trifluoromethyl)-benzenesulfonyl chloride (0.092 g) as a light yellow gum (0.048 g). MS (ESF): 427.1 ([M-H]').
Example 157: 2,4-Dichloro-6-methyl-N-[6-(3,3,3-trifluoro-propoxymethyl)-pyridin-2-yl]-benzenesulfonamide
This material was prepared in analogy to example 1 from 6-(3,3,3-Trifluoro-propoxymethyl)-pyridin-2-ylamine (0.075 g) and 2,4-dichloro-6-methyI-benzenesulfonyl chloride (0.097 g) as a light yellow gum (0.08 g). MS (ESP): 441.1 ([M-H]-).
Example 158: N-[6-(2,2,2-Trifluoro-ethoxymethyl)-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide
Step A]: 2,2-Dimethyl-N"[6-(2,2,2-trifluoro-ethoxymethyl)-pyridin-2-yl]-propionamide
This material was obtained in analogy to example 156 step A from N-(6-chloromethyl-pyridin-2-yl)-2,2-dimethyl-propionamide, 0.567 g, product of example 120 step A ], and 2,2,2-trifluoro-ethanol as a brown liquid (0.726 g) that was used directly in the next step.
Step B]: 6-(2,2,2-Trifluoro-ethoxymethyl)-pyridin-2-ylamine

This material was prepared in analogy to example 86 step B] from 2,2-Dimethyl-N-[6-(2,2,2-trifluoro-ethoxymethyl)-pyridin-2-yl]-propionamide (0.726 g) and 3M aqueous NaOH (5 mL) as a brown liquid (0.4 g). MS (El): 206.1 (NT).
Step C]: N-[6-(2,2,2-Trifluoro-ethoxymethyl)-pyridin-2-yl]-3-trifluoromethyl-
benzenesu 1 fonam ide
This material was prepared in analogy to example 1 from 6-(2,2,2-Trifluoro-ethoxymethyl)-pyridin-2-ylamine (0.08 g) and 3-(trifluoromethyl)-benzenesulfonyl chloride (0.104 g) as a light yellow gum (0.066 g). MS (ESr): 413.1 ([M-H]').
Example 159: 2,4-Dichloro-6-methyl-N-[6-(2,2,2-trifluoro-ethoxymethyl)-pyridin-2-yl]-benzenesulfonamide
This material was prepared in analogy to example 1 from 6-(2,2,2-Trifluoro-ethoxymethyl)-pyridin-2-ylamine (0.08 g) and 2,4-dichloro-6-methyl-benzenesulfonyl chloride (0.11 g) as a light yellow solid (0.1 g). MS (ESF): 427.1 ([M-H]").
Example 160: 3-Chloro-N-[6-(2-cyclopropyl-ethoxymethyl)-pyridin-2-yl]-benzenesulfonamide
Step A]: N-[6-(2-Cyclopropyl-ethoxymethyl)-pyridin-2-yl]-2,2-dimethyl-propionamide
This material was obtained in analogy to example 156 step A from N-(6-chloromethyi-pyridin-2-yl)-2,2-dimethyl-propionamide, 0.567 g, product of example 120 step A ], and 2-cyclopropyl-ethanol (0.51 g) as a light yellow oil (0.51 g). MS (ESI): 277.2
Step B]: 6-(2-Cyclopropyl-ethoxymethyl)-pyridin-2-ylamine
This material was prepared in analogy to example 86 step B] from N-[6-(2-cyclopropyl-ethoxymethyl)-pyridin-2-yl]-2,2-dimethyl-propionamide (0.51 g) and 3M aqueous NaOH (3.7 mL) as a light yellow oil (0.39 g) that was used directly in the next step.

Step C]: 3-Chloro-N-[6-(2-cyclopropyl-ethoxymethyl)-pyridin-2-yl]-
benzenesu 1 fonam ide
This material was prepared in analogy to example 1 from 6-(2-cyclopropyl-ethoxymethyl)-pyridin-2-ylamine (0.08 g) and 3-chloro-benzenesulfonyl chloride (0.095 g) as a light yellow gum (0.096 g). MS (ESI"): 365.0 ([M-H]-).
Example 161: N-[6-(2-CyclopropyI-ethoxymethyl)-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide
This material was prepared in analogy to example 1 from 6-(2-cyclopropyl-ethoxymethyl)-pyridin-2-ylamine (0.08 g) and 3-(trifluormethyl)-benzenesulfonyl chloride (0.11 g) as a light yellow gum (0.106 g). MS (ESI'): 399.2 ([M-H]').
Example 162: N-[6-(2-Cyclopropyl-ethoxymethyI)-pyridin-2-yl]-4-fluoro-3-trifluoromethyl-benzenesulfonamide
This material was prepared in analogy to example 1 from 6-(2-cyclopropyl-
ethoxymethyl)-pyridin-2-ylamine (0.08 g) and 4-fluoro-3-(trifluormethyl)-
benzenesulfonyl chloride (0.12 g) as a light yellow gum (0.08 g). MS (ESF): 417.0
([M-H]-).
Example 163: 2,4-Dichloro-N-[6-(2-cyclopropyl-ethoxymethyl)-pyridin-2-yl]-6-methyl-benzenesulfonamide
This material was prepared in analogy to example 1 from 6-(2-cyclopropyl-ethoxymethyl)-pyridin-2-ylamine (0.08 g) and 2,4-dichloro-6-methyl-benzenesulfonyl chloride (0.117 g) as a light yellow gum (0.088 g). MS (ESI'): 413.1 ([M-H]').
Example 164: 2,4-DichIoro-5-methyl-N-[6-(2,2,2-trifluoro-ethoxymethyl)-pyridin-2-yI]-benzenesulfonamide

This material was prepared in analogy to example 1 from 6-(2,2,2-Trifluoro-ethoxymethyl)-pyridin-2-ylamine (0.08 g) and 2,4-dichloro-5-methyl-benzenesulfonyl chloride (0.11 g) as a light yellow gum (0.095 g). MS (ESF): 427.1 ([M-H]').
Example 165: 2-Chloro-N-[6-(2££-trifluoro-ethoxymethyl)-pyridin-2-yl]-5-trifluoromethyl-benzenesulfonamide
This material was prepared in analogy to example 1 from 6-(2,2,2-Trifluoro-ethoxymethyl)-pyridin-2-ylamine (0.08 g) and 2-chloro-5-(trifluoromethyl)-benzenesulfonyl chloride (0.119 g) as a light yellow solid (0.123 g). MS (ESF): 447.0 ([M-HD.
Example 166: 2,4-Dichloro-N-[6-(3-chloro-benzyloxymethyl)-pyridin-2-yl]-6-methyl-benzenesulfonamide
Step A]: N-[6-(3-Chloro-benzyloxymethyl)-pyridin-2-yl]-2,2-dimethyl-propionamide
This material was prepared in analogy to example 86 step A] from N-(6-hydroxymethyl-pyridin-2-yl)-2,2-dimethyl-propionamide (0.73 g) and 3-chlorobenzyl bromide as a yellow oil (0.75 g). MS (ESI): 332.2 (MH+).
Step B]: 6-(3-Chloro-benzyloxymethyl)-pyridin-2-ylamine
This material was prepared in analogy to example 86 step B] from N-[6-(3-chloro-benzyloxymethyl)-pyridin-2-yl]-2,2-dimethyl-propionamide (0.75 g) and 3M aqueous NaOH (4.51 mL) as a brown liquid (0.56 g). MS (ESI): 249.1 (MH+).
Step C]: 2,4-Dichloro-N-[6-(3-chloro-benzyloxymethyl)-pyridin-2-yl]-6-methyl-
benzenesu Ifonam ide
This material was prepared in analogy to example 1 from 6-(3-chloro-benzyloxymethyl)-pyridin-2-ylamine (0.08 g) and 2,4-dichloro-6-methyl-

benzenesulfonyl chloride (0.092g) as a light yellow gum (0.039 g). MS (ESI"): 469.0 ([M-H]').
Example 167: N-[6-(3-Chloro-benzyloxymethyl)-pyridin-2-yl]-4-fluoro-3-trifluoromethyl-benzenesulfonamide
This material was prepared in analogy to example 1 from 6-(3-chloro-benzyloxymethyl)-pyridin-2-ylamine (0.08 g) and 4-fluoro-3-(trifluoromethyl)-benzenesulfonyl chloride (0.092g) as a light yellow gum (0.088 g). MS (ESf): 472.8 ([M-H]-).
Example 168: N-[6-(4-Chloro-benzyloxymethyl)-pyridin-2-yl]-4-fluoro-3-trifluoromethyl-benzenesulfonamide
Step A]: N-[6-(4-Chloro-benzyloxymethyl)-pyridin-2-yl]-2,2-dimethyl-propionamide
This material was prepared in analogy to example 86 step A] from N-(6-hydroxyrnethyl-pyridin-2-yI)-2,2-dimethyl-propionamide (0.73 g) and 4-chlorobenzyl bromide as a yellow oil (0.868 g). MS (ESI): 332.2 (MH+).
Step B]: 6-(4-Chloro-benzyloxyrnethyl)-pyridin-2-ylamine
This material was prepared in analogy to example 86 step B] from N-[6-(4-chloro-benzyloxymethyl)-pyridin-2-yl]-2,2-dimethyl-propionamide (0.868 g) and 3M aqueous NaOH (5,22 mL) as a light yellow liquid (0.63 g). MS (ESI): 249.1 (MH+).
Step C]: N-[6-(4-Chloro-benzyloxymethyl)-pyridin-2-yl]-4-fluoro-3-trifluoromethyl-benzenesulfonamide
This material was prepared in analogy to example 1 from 6-(4-chloro-benzyloxymethyl)-pyridin-2-ylamine (0.08 g) and 4-fluoro-3-(trifluoromethyl)-benzenesulfonyl chloride (0.092g) as a light yellow gum (0.039 g). MS (ESI'): 472.8 ([M-H]-).

Example 169: 2,4-Dichloro-N-[6-(4-chloro-benzyloxymethyl)-pyridin-2-yI]-6-methyl-benzenesulfonamide
This material was prepared in analogy to example 1 from 6-(4-chloro-benzyloxymethyl)-pyridin-2-ylamine (0.08 g) and 2,4-dichloro-6-methyl-benzenesulfonyl chloride (0.092 g) as an off-white solid (0.082 g). MS (ESI'): 469.0 ([M-H]-).
Example 170: N-[5-(2,2,2-Trifluoro-ethoxymethyl)-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide
Step A]: N-(5-Chloromethyl-pyridin-2-yl)-2,2-dimethyl-propionamide
This material was obtained in analogy to example 120 step A ], from N-(5-hydroxymethyl-pyridin-2-yl)-2,2-dimethyl-propionamide, 1.25 g, product of example 107 step B ], and thionyl chloride (0.65 mL) as a brown solid (0.87 g). MS (ESI): 227.2 (MH+).
Step B]: 2,2-Dimethyl-N-[5-(2,2,2-trifluoro-ethoxymethyl)-pyridin-2-yl]-propionamide
This material was obtained in analogy to example 156 step A ] from N-(5-chloromethyl-pyridin-2-yl)-2,2-dimethyl-propionamide ( 0.43 g) and 2,2,2-trifluoro-ethanol (0.41 mL) as a brown liquid (0.56 g) that was used directly in the next step.
Step C]: 5-(2,2,2-Trifluoro-ethoxyrnethyl)-pyridin-2-ylamine
This material was prepared in analogy to example 86 step B] from 2,2-dimethyl-N-[5-(2,2,2-trifluoro-ethoxymethyl)-pyridin-2-yl]-propionamide (0.56 g) and 3M aqueous NaOH (3.87 mL) as a crystalline white solid (0.123 g). MS (ESI): 207.1 (MH+).

Step DJ: N-[5-(2,2,2-Trifluoro-ethoxymethyl)-pyridin-2-yl]-3-trifluoromethyl-
benzenesulfonamide
This material was prepared in analogy to example 1 from 5-(2,2,2-Trifluoro-ethoxymethyl)-pyridin-2-ylamine (0.06 g) and 3-(trifluoromethyl)-benzenesulfonyl chloride (0,078 g) as an off-white solid (0.056 g). MS (ESF): 413.1 ([M-H]").
Example 171: 2,4-Dichloro-5-methyI-N-[5-(2,2,2-trifluoro-ethoxymethyl)-pyridin-2-yl]-benzenesulfonamide
This material was prepared in analogy to example 1 from 5-(2,2,2-Trifluoro-ethoxymethyl)-pyridin-2-ylamine (0.06 g) and 2,4-dichloro-6-methyl-benzenesulfonyl chloride (0.083 g) as an off-white solid (0.072 g). MS (ESf): 427.1 ([M-H]').
Example 172: 3-Chloro-2-methyl-N-(3,4,5,6-tetrahydro-2H-
[l,3']bipyridinyl-6'-yl)-benzenesulfonamide
Step A]: 6'-Nitro-3,4,5,6-tetrahydro-2H-[l,3']bipyridinyl
5-Bromo-2-nitropyridine (3.0 g), tetrabutylammonium iodide (0.273 g), potassium carbonate (2.24 g) and piperidine (1.6 mL) were dissolved in DMSO (25 mL) and heated at 80 °C for 12 hours. The mixture was diluted with ethyl acetate, filtered and the filtrate was concentrated in vacuo. To the residue was added water (75 mL) and the precipitate was isolated by filtration. The solid was evaporated three times from toluene to remove residual water and the product was further dried in vacuo to give 6'-nitro-3,4,5,6-tetrahydro-2H-[l,3']bipyridinyl (2.87 g) as a yellow powder. MS (El): 207.2
Step B]: 3,4,5, 6-Tetrahydro-2H-[l,3']bipyridinyl-6'-ylamine
To 6'-Nitro-3,4,5,6-tetrahydro-2H-[l,3']bipyridinyl (0.25 g) in THF (8 mL) was added iron (0.539 mg) and water (2.5 mL). Then acetic acid (0.35 mL) was added dropwise and the mixture was allowed to stir at 45 °C for 12 hours. TLC analysis confirmed complete consumption of the starting material. The suspension was filtered through celite and the filter cake was washed well with ethyl acetate. The filtrate was concentrated in vacuo prior to addition of 2N NaOH. The aqueous layer was saturated with NaCl and extracted with ethyl acetate. The organic phase was washed with brine,

dried over Na2SO4 and evaporated to give a residue that was purified by flash chromatography on silica gel (gradient of MeOH in DCM containing 0.5% NFLjOH). 3,4,5,6-tetrahydro-2H-[l,3']bipyridinyl-6'-ylamine was obtained as a black oil (0.196 g). MS (ESI): 178.1 (MH4).
3A5,6-Tetrahydro-2H-[l,31bipyridinyl-6'-ylamine (0.19 g) and 3-chloro-2-
methylbenzenesulfonyl chloride (0.24 g) were dissolved in pyridine (4 mL) and heated
at 50 °C over night. The mixture was concentrated in vacuo, taken up in ethyl acetate
and extracted with 1M Cu(II)SO4 solution. The organic layer was washed once again
with Cu(II)SC>4 solution, dried over Na2SO4 and evaporated in vacuo. The product was
purified by flash chromatography on silica gel (gradient of ethyl acetate in heptane) to
give 3-chloro-2-methyl-N-(3,4,5,6-tetrahydro-2H-[ 1,3']bipyridinyl-6'-yl)-
benzenesulfonamide (0.1 g) as a light brown foam. MS (ESI"): 364.0 ([M-H]").
Example 173: 3-ChIoro-2-methyl-N-(5-pyrroIidin-l-yI-pyridin-2-yl)-
benzenesulfonamide
3-Chloro-2-methyl-N-(5-pyrrolidin-1 -yl-pyridin-2-yl)-benzenesulfonamide was
obtained in analogy to example 172, steps A] to C] from 5-bromo-2-nitropyridine, pyrrolidine and 3-chloro-2-methylbenzenesulfonyl chloride as a yellow foam. MS (ESI" ): 350.2 ([M-H]").
Example 174: 3-Chloro-2-methyl-N-(5-morpholin-4-yl-pyridin-2-yl)-
benzenesulfonamide
3-Chloro-2-methyl-N-(5-morpholin-4-yl-pyridin-2-yl)-benzenesulfonamide was
obtained in analogy to example 172, steps A] to C] from 5-bromo-2-nitropyridine, morpholine and 3-chloro-2-methylbenzenesulfonyl chloride as a light yellow powder. MS (ESI'): 366.0 ([M-H]").

Example 175: N-(5-Benzyl-pyridin-2-yl)-3-chloro-2-methyl-
benzenesulfonamide
N-(5-Benzyl-pyridin-2-yl)-3-chloro-2-methyl-benzenesulfonamide was made in analogy to example 172, step C] from known 5-benzyl-pyridin-2-ylamine (made according to Kelly et al., J. Am. Chem. Soc. 112 (22), 1990, 8024-8034) and 3-chloro-2-methylbenzenesulfonyl chloride and was obtained as a white powder. MS (ESI"): 371.1 ([M-H]-).
Example 176: 3-Chloro-2-methyl-N-(5-phenethyl-pyridin-2-yl)-
benzenesulfonamide
Step A]: 5-Phenethyl-pyridin-2-ylamine
5-Phenethyl-pyridin-2-ylamine which has been described in the literature (Kaminski et al., J. Med. Chem. 28 (7), 1985, 876-892) was made from known 5-styryl-pyridin-2-ylamine (Bumagin et al., J. Organomet. Chem. 486 (1-2), 1995, 259-262) by catalytic hydrogenation: 5-Styryl-pyridin-2-ylamine (0.3 g) was dissolved in ethanol (6 mL) and 5% Pd on charcoal (38 mg) was added. A hydrogen atmosphere was introduced by repeated evacuation / hydrogen introduction and the suspension was allowed to stir at RT for 2 hours. The mixture was filtered through celite and the filter cake was washed well with ethanol. The filtrate was evaporated to give 5-phenethyl-pyridin-2-ylamine as a colorless solid (100 mg) that was not further purified. MS (ESI): 199.1 (MH+).
Step B]: 3-Chloro-2-methyl-N-(5-phenethyl-pyridin-2-yl)-benzenesulfonamide
3-Chloro-2-methyl-N-(5-phenethyl-pyridin-2-yl)-benzenesulfonamide was made in analogy to example 172, step C] from 5-phenethyl-pyridin-2-ylamine (117 mg) and 3-chloro-2-methylbenzenesulfonyl chloride (133 mg) to give the desired product as a white powder (129 mg). MS (ESr): 385.0 ([M-H]')
Example 177: 3-Chloro-2-methyl-N-(6-methyl-5-phenethyl-pyridin-2-yl)-
benzenesulfonamide
Step A]: 6-Methyl-5-styryl-pyridin-2-ylamine

5-Bromo-6-methyl-pyridin-2-ylamine (0.5 g), styrene (0.28 g) and potassium formate (0.68 g) were dissolved in DMF (5 mL). Tetrabutylammonium chloride (0.74 g) and palladium(Il)acetate (30 mg) were added and the mixture was stirred under argon at 60 °C for 18 hours; a black suspension was obtained. The mixture was poured into saturated NaHCCb solution (75 mL) and extracted with ethyl acetate. The organic layers were washed with brine, dried over NaaSCU and evaporated. The residue was purified by flash chromatography (silica gel, gradient of ethyl acetate in heptane) to give 6-methyl-5-styryl-pyridin-2-ylamine (144 mg) as a 7:3 mixture of (E) and (Z) isomers as a white foam. MS (ESI): 211.3 (MH*). This material was contaminated with trace amounts of 6-methyl-5-phenethyl-pyridin-2-ylamine according to MS analysis.
Step B] 6-Methyl-5-phenethyl-pyridin-2-ylamine
6-Methyl-5-styryl-pyridin-2-ylamine (141 mg) was hydrogenated in analogy to example 176, step A] to give 6-methyl-5-phenethyl-pyridin-2-ylamine (139 mg) as light brown foam. MS (ESI): 213.3 (MFT).
Step C] 3-Chloro-2-methyl-N-(6-methyl-5-phenethyl-pyridin-2-yl)-
benzenesulfonamide
This material was obtained from 6-methyl-5-phenethyl-pyridin-2-ylamine (134 mg) and 3-chloro-2-methylbenzenesulfonyl chloride (142 mg) in analogy to example 172, step C] as white foam (166 mg). MS (ESF): 399.1 ([M-H]").
Example 178: 3-ChIoro-2-methyl-N-(5-thiomorpholin-4-yl-pyridin-2-yl)-
benzenesulfonamide
3-Chloro-2-methyl-N-(5-thiomorpholin-4-yl-pyridin-2-yl)-benzenesulfonamide was obtained in low yield in analogy to example 172, steps A] to C] from 5-bromo-2-nitropyridine, thiomorpholine and 3-chloro-2-methylbenzenesulfonyl chloride as a reddish, viscous oil. MS (ESI"): 382.1 ([M-H]').
Example 179: 2,4-Dichloro-N-{5-[2-(4-chloro-phenyl)-ethyl]-pyridin-2-yI}-
6-methyl-benzenesuIfonamide

This material was obtained in analogy to example 177, steps A] to C] from 5-iodo-pyridin-2-ylamine, 1 -chloro-4-vinyl-benzene and 2,4-dichloro-6-methylbenzenesulfonyl chloride as a light yellow powder. MS (ESI"): 353.1 ([M-H]").
Example 180: 3-ChIoro-N-{5-[2-(4-methoxy-phenyl)-ethyI]-pyridin-2-yl}-2-
methyl-benzenesulfonamide
This material was obtained in analogy to example 177, steps A] to C] from 5-iodo-pyridin-2-ylamine, l-methoxy-4-vinyl-benzene and 3-chloro-2-methylbenzenesulfonyl chloride as a light yellow foam. MS (ESF): 415.3 ([M-H]").
Example 181: 3-Chloro-N-{5-[2-(3-fluoro-phenyl)-ethyl]-pyridin-2-yl}-2-
methyl-benzenesulfonamide
This material was obtained in analogy to example 177, steps A] to C] from 5-iodo-pyridin-2-ylamine, l-fluoro-3-vinyl-benzene and 3-chloro-2-methylbenzenesulfonyl chloride as a light yellow foam. MS (ESF): 403.4 ([M-H]').
Example 182: 3-ChIoro-2-methyl-N-{5-[2-(2-trifluoromethyl-phenyl)-
ethyl]-pyridin-2-yl} benzenesulfonamide
This material was obtained in analogy to example 177, steps A] to C] from 5-iodo-
pyridin-2-ylamine, l-trifluoromethyl-2-vinyl-benzene and 3-chloro-2-
methylbenzenesulfonyl chloride as a white foam. MS (ESI"): 453.3 ([M-H]").
Example 183: 3-Chloro-N-{5-[2-(4-fluoro-phenyl)-ethyl]-pyridin-2-yl}-2-
methyi-benzenesulfonamide
This material was obtained in analogy to example 177, steps A] to C] from 5-iodo-pyridin-2-ylamine, l-fluoro-4-vinyl-benzene and 3-chloro-2-methylbenzenesulfonyl chloride as a light yellow foam. MS (ESI"): 403.4 ([M-H]').
Example 184: 3-Chloro-2-methyl-N-(5-phenoxy-pyridin-2-yl)-
benzenesulfonamide
Step A] 2-Nitro-5-phenoxy-pyridine
Phenol (306 mg) was dissolved in dry DMF (5 mL) and subsequently, sodium hydride (60% in mineral oil, 130 mg) was added which resulted in strong hydrogen gas evolution. The mixture was then allowed to stir at RT for 30 minutes. Subsequently, 5-bromo-2-nitro-pyridine (600 mg) was added und the resulting mixture was stirred at 60 °C for 12 hours. The reaction mixture was poured into ice water and the aqueous phase was saturated with NaCl and extracted with ethyl acetate. The organic layer was separated, washed with brine, dried over Na2S(>4 and evaporated. The residue was purified by flash chromatography (silica gel, gradient of ethyl acetate in heptane) to give 2-nitro-5-phenoxy-pyridine as a light yellow foam (267 mg). MS (El): 216.1 (M+).
Step B] 5-Phenoxy-pyridin-2-ylamine
2-Nitro-5-phenoxy-pyridine (262 mg) was dissolved in dry ethanol (12 mL) and 10% palladium on charcoal (90 mg) was added. A hydrogen atmosphere was introduced by repeated evacuation / hydrogen introduction. The mixture was then allowed to stir for 18 hours. The catalyst was removed by filtration through celite and the filtrate was concentrated in vacuo to give 5-phenoxy-pyridin-2-ylamine (217 mg) as a yellow foam. This material was used without further purification. MS (El): 186.1 (M+).
Step C] 3-Chloro-2-methyl-N-(5-phenoxy-pyridin-2-yl)-
benzenesulfonamide
5-Phenoxy-pyridin-2-ylamine (100 mg) was treated with 3-chloro-2-methylbenzenesulfonyl chloride (122 mg) in the presence of pyridine (3 mL) as described in example 172, step C] to give 3-Chloro-2-methyl-N-(5-phenoxy-pyridin-2-yl)-benzenesulfonamide (37 mg) as a white foam. MS (ESI): 375.1 (MH+).
Example 185: 3-Chloro-N-[5-(2-chloro-phenoxy)-pyridin-2-yI]-2-methyl-
benzenesulfonamide
This material was obtained in analogy to example 184, steps A] to C] from 2-chloro-phenol, 5-bromo-2-nitro-pyridine and 3-chloro-2-methylbenzenesulfonyl chloride as a white foam. MS (ESF): 407.1 ([M-H]').

Example 186: 3-ChIoro-N-[5-(4-fluoro-phenoxy)-pyridin-2-yl]-2-methyl-
benzenesulfonamide benzenesulfonamide
This material was obtained in analogy to example 184, steps A] to C] from 4-fluoro-phenol, 5-bromo-2-nitro-pyridine and 3-chloro-2-methylbenzenesulfonyl chloride as a white solid. MS (ESI): 392.9 (MH+).
Example 187: 2,4-Dichloro-6-methyl-N-(5-phenoxy-pyridin-2-yl)-
benzenesulfonamide
This material was obtained in analogy to example 184, steps A] to C] from phenol, 5-bromo-2-nitro-pyridine and 2,4-dichloro-6-methylbenzenesulfonyl chloride as a light brown solid. MS (ESI"): 407.1 ([M-H]').
Example 188: 2,4-Dichloro-N-[5-(2-chloro-phenoxy)-pyridin-2-yl]-6-
methyl-benzenesulfonamide
This material was obtained in analogy to example 184, steps A] to C] from 2-chloro-phenol, 5-bromo-2-nitro-pyridine and 2,4-dichloro-6-methylbenzenesulfonyl chloride as a light yellow foam. MS (ESF): 441.0 ([M-H]').
Example 189: 2,4-DichIoro-N-[5-(4-fluoro-phenoxy)-pyridin-2-yl]-6-
methyl-benzenesulfonamide
This material was obtained in analogy to example 184, steps A] to C] from 4-fluoro-phenol, 5-bromo-2-nitro-pyridine and 2,4-dichloro-6-methylbenzenesulfonyl chloride as a light brown solid. MS (ESF): 425.0 ([M-H]").
Example 190: 3-Chloro-2-methyl-N-|5-(2-quinolin-2-yl-ethyl)-pyridin-2-
yl]-benzenesulfonamide

This material was obtained in analogy to example 177, steps A] to C] from 5-iodo-pyridin-2-ylamine, 2-vinyl-quinoline and 3-chloro-2-methylbenzenesulfonyl chloride as a light yellow foam. MS (ESF): 436.2 ([M-H]').
Example 191: 2,4-Dichloro-6-methyl-N-[5-(2-quinolin-2-yl-ethyl)-pyridin-
2-yl]-benzenesulfonamide
This material was obtained in analogy to example 177, steps A] to C] from 5-iodo-pyridin-2-ylamine, 2-vinyl-quinoline and 2,4-dichloro -6-methylbenzenesulfonyl chloride as a light yellow foam. MS (ESF): 470.0 ([M-H]').
Example 192: 3-Chloro-2-methyl-N-[5-(2-pyridin-2-yl-ethyl)-pyridin-2-yl]-
benzenesulfonamide
This material was obtained in analogy to example 177, steps A] to C] from 5-iodo-pyridin-2-ylamine, 2-vinyl-pyridine and 3-chloro-2-methylbenzenesulfonyl chloride as a white powder. MS (ESF): 386.0 ([M-H]").
Example A
A compound of formula I can be used in a manner known per se as the active ingredient for the production of tablets of the following composition:
Per tablet
Active ingredient 200 mg
Microcrystalline cellulose 155 mg
Corn starch 25 mg
Talc 25 mg
Hydroxypropylmethylcellulose 20 mg
425 mg

Example B
A compound of formula I can be used in a manner known per se as the active ingredient for the production of capsules of the following composition:
Per capsule
Active ingredient lOO.Omg
Corn starch 20.0 mg
Lactose 95.0 mg
Talc 4.5 mg
Magnesium stearate 0.5 mg
220.0 mg





We Claim:
1. Alkil-pyridine compounds of formula (I)
(Formula Removed)
wherein
R1 is hydrogen, alkyl, cycloalkyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, aminoalkyl, aryl, alkylsulfonyl, alkylsulfanyl, alkylcarbonylalkyl, alkylcarbonyloxyalkyl, aminocarbonylalkyl, heterocyclylcarbonylalkyl, heterocyclylalkoxyalkyl, alkoxycarbonylalkyl, alkoxyalkylaminocarbonylalkyl, cycloalkylalkoxyalkyl, arylalkyloxyalkyl, aryloxyalkyl, haloalkyl, haloalkoxy or haloalkoxyalkyl;
R2 is hydrogen, alkyl, cycloalkylalkoxyalkyl, alkoxyalkyl, arylalkoxyalkyl, haloalkoxyalkyl, piperidyl, pyrrolidyl, morpholinyl, thiomorpholinyl, arylalkyl, arylalkoxy, aryloxy, heterocyclylalkoxy or heterocyclylalkyl;
R3 is hydrogen or alkyl;
R4 is hydrogen, alkyl or halogen;
R5 is phenyl, naphtyl, thiophenyl, pyridyl, quinolyl, piperidyl, morpholyl, thiomorpholyl or 1,2,3,4-tetrahydro-isoquinolinyI optionally substituted with one or more substituents independently selected from alkyl, cycloalkyl, halogen, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, hydroxyalkoxy, alkoxyalkoxy, cyano, nitro, trifluoromethyl, trifluoromethoxy, trifluoromethylcarbonyl, aryl, arylalkyl, aryloxy, alkoxycarbonylalkoxy and alkylsulfonyl;
R6 is hydrogen or alkyl;
and pharmaceutically acceptable salts and esters thereof; with the proviso that N-(6-(1,1-dimethylethyl)-2-pyridinyl)-4-methyl-benzenesulfonamide is excluded and in case R1 is hydrogen or methyl then R2 is not hydrogen or methyl and with the proviso that
N-(6-phenyl-2-pyridinyl)-benzenesulfonamide;
Ethyl [6-(3-Chloro-2-methyI-benzenesulfonylamino)-pyridin-2-yl]-acetate;
[6-(4'-Cyano-biphenyl-4-sulfonylamino)-pyridin-2-yl]-acetic acid ethyl ester;
[6-(4-Trifluoromethyl-benzenesulfonylamino)-pyridin-2-yl]-acetic acid ethyl ester;
3-Chloro-2-methyl-N-[6-(2-morpholin-4-yl-2-oxo-ethyl)-pyridin-2-yl]-benzenesulfonamide;
3-Chloro-2-methyl-N-[6-(2-oxo-2-piperidin-1 -yl-ethyl)-pyridin-2-yl]-benzenesulfonamide;
3-Chloro-2-methyl-N-[6-(2-oxo-2-thiomorpholin-4-yl-ethyl)-pyridin-2-yl]-benzenesulfonamide;
3-Chloro-2-methyl-N-[6-[2-(4-methylpiperazin-l-yl)-2-oxo-ethyl]-pyridin-2-yl]-benzenesulfonamide;
N-[6-[2-(4-Benzyl-piperazin-l-yl)-2-oxo-ethyl]-pyridin-2-yl]-3-chloro-2-methyl benzenesulfonamide;
3-Chloro-2-methyl-N-[4-methyl-6-(2-oxo-2-piperidin-l-yl-ethyl]-pyridin-2-yl]-benzenesulfonamide;
2-[6-(3-Chloro-2-methyl-benzenesulfonylamino)-4-methyl-pyridin-2-yl]-N,N-diethyl-acetamide;
3-Chloro-2-methyl-N-[6-(2-oxo-2-pyrrolidin-l-yl-ethyl]-pyndin-2-yl]-benzenesulfonamide;
N,N-diethyl-2-[6-(3-Chloro-2-methyl-benzenesulfonylamino)-pyridin-2-yl]-acetamide;
N,N-diethyl-2-[6-(4-trifluoromethylbenzenesulfonylamino)-pyridin-2-yl]-acetamide;
N,N-diethyl-2-[6-(naphthalene-2-sulfonylamino)-pyridin-2-yl]-acetamide;
N,N-diethyl-2-[6-(toluene-4-sulfonylamino)-pyridin-2-yl]-acetamide;
N,N-diethyl-2-[6-(4-fluoro-ben2enesulfonylamino)-pyridin-2-yl]-acetamide;
N,N-diethyl-2-[6-(4-isopropyl-benzenesulfonylamino)-pyridin-2-yl]-acetamide;
3-Chloro-N-[6-[2-(3,3-dimethyl-piperidin-l-yl)-2-oxo-ethyl]-pyridin-2-yl]-2-methyl-benzenesulfonamide;
2-[6-(3-Chloro-2-methylbenzenesulfonylamino)-pyridin-2-yl]-N-isopropyl-N-methyl-acetamide;
2-[6-(3-Chloro-2-methylbenzenesulfonylamino)-pyridin-2-yl]-N,N-dimethyl-acetamide;
3-Chloro-N-(6-ethyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;
N-(6-Methoxy-pyridin-2-yl)-4-trifluoromethyl-benzenesulfonamide;
Biphenyl-4-sulfonic acid (5-methyl-pyridin-2-yl)-amide;
N-(6-Ethyl-pyridin-2-yl)-4-trifluoromethyl-benzenesulfonamide;
N-(6-Ethyl-pyridin-2-yl)-4-isopropyl-benzenesulfonamide;
4'-Cyano-biphenyl-4-sulfonic acid (6-methoxypyridin-2-yl)-amide;
4'-Cyano-biphenyl-4-sulfonic acid(6-dimethylaminomethyl-pyridin-2-yl)-amide;
4'-Cyano-biphenyl-4-sulfonic acid (6-ethyl-pyridin-2-yl)-amide;
4'-Cyano-biphenyl-4-sulfonic acid(6-isopropyl-pyridin-2-yl)-amide;
4'-Cyano-biphenyl-4-sulfonic acid(6-cyclopropyl-pyridin-2-yl)-amide;
3-Chloro-N-[6-(2-hydroxy-ethyl)-pyridin-2-yl)]-2-methyl-benzenesulfonamide;
3-Chloro-N-[6-hydroxymethyl-pyridin-2-yl)]-2-methyl-benzenesulfonamide;
4'-Cyano-biphenyl-4-sulfonic acid[6-(2-hydroxy-ethyl)-pyridin-2-yl]-amide;
6-(4-Cyano-phenyl)-pyridin-3-sulfonic acid(6-cyclopropyl-pyridin-2-yl)-amide;
6-(4-Trifluoromethyl-phenyl)-pyridin-3 -sulfonic acid (6-cyclopropyl-pyridin-2-yl)-amide; and
3,4-Dihydro-lH-isoquinoline-2-sulfonic acid (6-ethyl-pyridin-2-yl)-amide are excluded.
2. The compounds as claimed in claim 1, wherein R5 is phenyl, naphtyl, piperidyl or 1,2,3,4-tetrahydro-isoquinolinyl optionally substituted with one to three substituents independently selected from alkyl, halogen, alkoxy, nitro, trifluoromethyl, trifluoromethoxy, trifluoromethylcarbonyl, aryl, aryloxy and alkylsulfonyl.
3. The compounds as claimed in claim 1 or 2, wherein R5 is phenyl or naphtyl optionally substituted with one to three substituents independently selected from alkyl, halogen, trifluoromethyl, trifluoromethoxy and aryl.
4. The compounds as claimed in any one of claims 1 to 3, wherein R6 is hydrogen.
5. The compounds as claimed in any one of claims 1 to 4, wherein R1 is alkyl, cycloalkyl, hydroxyalkyl, alkoxyalkyl, aryl, alkoxyalkylaminocarbonylalkyl, cycloalkylalkoxyalkyl, arylalkyloxyalkyl or trifluoroalkoxyalkyl.
6. The compounds as claimed in any one of claims 1 to 4, wherein R1 is hydrogen.
7. The compounds as claimed in any one of claims 1 to 6, wherein R2 is hydrogen, cycloalkylalkoxyalkyl, alkoxyalkyl, piperidyl, pyrrolidyl, morpholinyl, thiomorpholinyl, arylalkyl or aryloxy.
8. The compounds as claimed in any one of claims 1 to 7, wherein R3 is hydrogen.
9. The compounds as claimed in any one of claims 1 to 8, wherein R4 is hydrogen or halogen.
10. The compounds as claimed in any one of claims 1 to 9, wherein R4is hydrogen.
11. The compounds as claimed in any one of claims 1 to 10 selected from
3-Chloro-N-(6-ethyl-pyridin-2-yl)-2-methyl-benzenesulfonamide; Biphenyl-4-sulfonic acid (6-ethyl-pyridin-2-yl)-amide; Biphenyl-4-sulfonic acid (6-propyl-pyridin-2-yl)-amide; 3-Chloro-2-methyl-N-(6-propyl-pyridin-2-yl)-benzenesulfonamide; Naphthalene-2-sulfonic acid (6-propyl-pyridin-2-yl)-amide; 3,4-Dichloro-N-(6-propyl-pyridin-2-yl)-benzenesulfonamide; 2,5-Difluoro-N-(6-propyl-pyridin-2-yl)-benzenesulfonamide; 2,4-Dichloro-6-methyl-N-(6-propyl-pyridin-2-yl)-benzenesulfonamide; 5-Chloro-naphthalene-2-sulfomc acid (6-propyl-pyridin-2-yl)-amide; 3,4-Dimethoxy-N-(6-propyl-pyridin-2-yl)-benzenesulfonamide; 4,5-Dichloro-2-fluoro-N-(6-propyl-pyridin-2-yl)-benzenesulfonamide; 2,4-Dichloro-5-methyl-N-(6-propyl-pyridin-2-yl)-benzenesulfonamide; Piperidine-1-sulfonic acid (6-propyl-pyridin-2-yl)-amide;
3-Chloro-N-(6-isopropyl-pyridin-2-yl)-4-methyl-benzenesulfonamide;
2,5-Difluoro-N-(6-isopropyl-pyridin-2-yl)-benzenesulfonamide;
N-(6-lsopropyl-pyridin-2-yl)-4-(4-trifluoromethyl-phenoxy)-benzenesulfonamide;
2,4-Dichloro-N-(6-isopropyl-pyridin-2-yl)-5-methyl-benzenesulfonamide;
N-(6-Isopropyl-pyridin-2-yl)-4-methanesulfonyl-benzenesulfonamide;
N-(6-Isopropyl-pyridin-2-yl)-4-trifluoromethoxy-benzenesulfonamide;
2-(2,2,2-Trifluoro-acetyl)-l ,2,3,4-tetrahydro-isoquinoline-7-sulfonic acid (6-isopropyl-pyridin-2-yl)-amide;
N-(6-Isopropyl-pyridin-2-yl)-3-(4-trifluoromethyl-phenoxy)-benzenesulfonamide;
Naphthalene-2-sulfomc acid (6-isopropyl-pyridin-2-yl)-amide;
N -(6-Isopropyl-pyridin-2-yl)-3 -trifluoromethyl-benzenesulfonamide;
N-[6-(2-Chloro-phenyl)-pyridin-2-yl]-5-fluoro-2-methyl-benzenesulfonamide;
3-Chloro-N-[6-(2-chloro-phenyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide;
Biphenyl-4-sulfonic acid [6-(2-chloro-phenyl)-pyridin-2-yl]-amide;
3-Chloro-N-[6-(2,4-difluoro-phenyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide;
3-Chloro-N-[6-(3-fluoro-phenyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide;
3-Chloro-N-[6-(2,3-difluoro-phenyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide;
3-Chloro-N-[6-(2,5-dichloro-phenyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide;
N-[6-(2,5-Dichloro-phenyl)-pyridin-2-yl]-5-fluoro-2-methyl-benzenesulfonamide;
3-Chloro-N-[6-(3-chloro-phenyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide;
N-[6-(3-Chloro-phenyl)-pyridin-2-yl]-5-fluoro-2-methyl-benzenesulfonamide;
3-Chloro-N-[6-(2-fluoro-phenyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide;
5-Fluoro-N-[6-(2-fluoro-phenyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide;
3-Chloro-2-methyl-N-[6-(2-trifluoromethyl-phenyl)-pyndin-2-yl]-benzenesulfonamide;
5-Fluoro-2-methyl-N-[6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-benzenesulfonamide;
N-[6-(2-Chloro-phenyl)-pyridin-2-yl]-2,5-difluoro-benzenesulfonamide;
N-[6-(2-Chloro-phenyl)-pyridin-2-yl]-2-trifluoromethyl-benzenesulfonamide;
3-Chloro-N-[6-(2-methoxy-phenyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide;
3-Chloro-N-[6-(4-fluoro-2-methyl-phenyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide;
5-Fluoro-N-[6-(4-fluoro-2-methyl-phenyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide;
N-[2,3']Bipyridinyl-6-yl-3-chloro-2-methyl-benzenesulfonamide;
2,5-Difluoro-N-[6-(4-fluoro-2-methyl-phenyl)-pyridin-2-yl]-benzenesulfonamide;
2,4-Dichloro-N-[6-(4-fluoro-2-methyl-phenyl)-pyridin-2-yl]-6-methyl-benzenesulfonamide;
3,4-Dichloro-N-[6-(4-fluoro-2-methyl-phenyl)-pyridin-2-yl]-benzenesulfonamide;
3-Chloro-N-(6-methoxy-pyridin-2-yl)-2-methyl-benzenesulfonamide;
Biphenyl-4-sulfonic acid (6-methoxy-pyridin-2-yl)-amide;
5-Fluoro-N-(6-methoxy-pyridin-2-yl)-2-methyl-benzenesulfonamide;
Naphthalene-2-sulfomc acid (6-methoxy-pyridin-2-yl)-amide;
3-Chloro-N-(6-ethoxy-pyridin-2-yl)-2-methyl-benzenesulfonamide;
Biphenyl-4-sulfonic acid (6-ethoxy-pyridin-2-yl)-amide;
Naphthalene-2-sulfonic acid (6-ethoxy-pyridin-2-yl)-amide;
3-Chloro-N-(6-ethylsulfanyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;
Biphenyl-4-sul tonic acid (6-ethylsulfanyl-pyridin-2-yl)-amide;
Naphthalene-2-sulfonic acid (6-ethylsulfanyl-pyndin-2-yl)-amide;
Naphthalene-2-sulfonic acid (6-ethanesulfonyl-pyridin-2-yl)-amide;
3-Chloro-2-methyl-N-[6-(2-oxo-pentyl)-pyridin-2-yl]-benzenesulfonamide;
2-[6-(Biphenyl-4-sulfonylamino)-pyridin-2-yl]-N,N-diethyl-acetamide;
Biphenyl-4-sulfonic acid[6-(2-morpholin-4-yl-2-oxo-ethyl)-pyridin-2-yl]-amide;
[6-(3-Chloro-2-methyl-benzenesulfonylamino)-pyridin-2-yl]-acetic acid methyl ester;
[6-(5-Fluoro-2-methyl-benzenesulfonylamino)-pyridin-2-yl]-acetic acid methyl ester;
N,N-Diethyl-2-[6-(4'-fluoro-biphenyl-4-sulfonylamino)-pyridin-2-yl]-acetamide;
4-Fluoro-biphenyl-4-sulfonic acid [6-(2-morpholin-4-yl-2-oxo-ethyl)-pyridin-2-yl]-amide;
2-[6-(4-Fluoro-biphenyl-4-sulfonylamino)-pyridin-2-yl]-N-(2-methoxy-ethyl)-acetamide;
2-[6-(3-Chloro-2-methyl-benzenesulfonylamino)-pyridin-2-yl]-N,N-diethyl-acetamide;
2-[6-(3,4-Dichloro-benzenesulfonylamino)-pyridin-2-yl]-N,N-diethyl-acetamide
2-[6-(3-Chloro-2-methyl-benzenesulfonylamino)-3-methyl-pyridin-2-yl]-N,N-diethyl-acetamide;
2-[6-(3,4-Dichloro-benzenesulfonylamino)-3-methyl-pyridin-2-yl]-N,N-diethyl-acetamide;
3-Chloro-N-(6-hydroxymethyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;
3-Chloro-N-(6-methoxymethyl-pyndin-2-yl)-2-methyl-benzenesulfonamide;
2,5-Difluoro-N-(6-methoxymethyl-pyndin-2-yl)-benzenesulfonamide;
3-Chloro-N-(6-methoxymethyl-pyridin-2-yl)-4-methyl-benzenesulfonamide;
N-(6-Cyclopropylmethoxymethyl-pyridin-2-yl)-2,5-difluoro-benzenesulfonamide;
5-Fluoro-N-(6-methoxymethyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;
2,5-Difluoro-N-(6-hydroxymethyl-pyridin-2-yl)-benzenesulfonamide;
Acetic acid 6-(2,5-difluoro-benzenesulfonylamino)-pyridin-2-ylmethyl ester;
Naphthalene-2-sulfomc acid (6-hydroxymethyl-pyridin-2-yl)-amide;
3-Chloro-N-(6-cyclopropylmethoxymethyl-pyridin-2-yl)-4-methyl-benzenesulfonamide;
N-(6-Cyclopropylmethoxymethyl-pyridin-2-yl)-5-fluoro-2-methyl-benzenesulfonamide;
3-Chloro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-4-methyl-benzenesulfonamide;
3-Chloro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide;
2,5-Difluoro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-benzenesulfonamide;
5-Fluoro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide;
Piperidine-1-sulfonic acid (6-methoxymethyl-pyridin-2-yl)-amide;
Piperidine-1 -sulfonic acid (6-cyclopropylmethoxymethyl-pyridin-2-yl)-amide
3-Chloro-4-methyl-N-[6-(4-trifluoromethyl-phenoxymethyl)-pyridin-2-yl]-benzenesulfonamide;
3-Chloro-2-methyl-N-[6-(4-trifluoromethyl-phenoxymethyl)-pyridin-2-yl]-benzenesulfonamide;
2,5-Difluoro-N-[6-(4-trifluoromethyl-phenoxymethyl)-pyridin-2-yl]-benzenesulfonamide;
5-Fluoro-2-methyl-N-[6-(4-trifluoromethyl-phenoxymethyl)-pyridin-2-yl]-benzenesulfonamide;
3-Chloro-N-(6-cyclopropylmethoxymethyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;
3,4-Dichloro-N-(6-cyclopropylmethoxymethyl-pyridin-2-yl)-benzenesulfonamide;
4-Fluoro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-benzenesulfonamide;
N-[6-(4-Fluoro-benzyloxymethyl)-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide;
3-Chloro-N-(5-cyclopropylmethoxymethyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;
N-(5-Cyclopropyl-methoxymethyl-pyridm-2-yl)-2,5-difluoro-benzenesulfonamide
4-Chloro-N-(5-cyclopropylmethoxymethyl-pyridin-2-yl)-3-methyl-benzenesulfonamide;
N-(5-Cyclopropylmethoxymethyl-pyridin-2-yl)-5-fluoro-2-methyl-benzenesulfonamide;
Piperidine-1 -sulfonic acid (5-cyclopropyl-methoxymethyl-pyridin-2-yl)-amide;
3-Chloro-N-(5-cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;
N-(5-Cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-2,5-difluoro-benzenesulfonamide;
N-(5-Cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-5-fluoro-2-methyl-benzenesulfonamide;
N-(5-Methoxymethyl-6-methyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide;
3-Chloro-N-(5-methoxymethyl-6-methyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;
N-[5-(4-Fluoro-benzyloxymethyl)-6-methyl-pyridin-2-yl]-3-trifluoromethylbenzenesulfonamide;
3-Chloro-N-[5-(4-fluoro-benzyloxymethyl)-6-methyl-pyridin-2-yl]-2-methylbenzenesulfonamide;
N-(5-Ethoxymethyl-6-methyl-pyridin-2-yl)-3-trifluoromethylbenzenesulfonamide;
3-Chloro-2-methyl-N- {6-[(methyl-propyl-amino)-methyl]-pyridin2-yl} -benzenesulfonamide;
5-Fluoro-2-methyl-N-{6-[(methyl-propyl-amino)-methyl]-pyridin-2-yl}-benzenesulfonamide;
3-Chloro-N-(5-ethoxyniethyl-6-methyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;
3-Chloro-N-(6-cyclopropyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;
Naphthalene-1-sulfonic acid (6-cyclopropyl-pyridin-2-yl)-amide;
4-Chloro-N-(6-cyclopropyl-pyridin-2-yl)-2,5-dimethyl-benzenesulfonamide;
4-Chloro-N-(6-cyclopropyl-pyridin-2-yl)-3-methyl-benzenesulfonamide;
N-(6-Cyclopropyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide;
2,4-Dichloro-N-(6-cyclopropyl-pyridin-2-yl)-5-methylbenzenesulfonamide;
Naphthalene-2-sulfonic acid (6-cyclopropyl-pyridin2-yl)-amide;
N-(5-Cyclopropylmethoxymethyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide;
N-(5-Ethoxymethyl-6-methyl-pyridin-2-yl)-3,5-bis-trifluoromethyl-benzenesulfonamide;
4-Chloro-N-(5-ethoxymethyl-6-methyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide;
4-Chloro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide;
4-Chloro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-2,5-dimethyl-benzenesulfonamide;
3-Trifluoromethyl-N-[6-(4-trifluoromethyl-phenoxymethyl)-pyridin-2-yl]-benzenesulfonamide;
N-[5-(2-Fluoro-ethoxymethyl)-6-methyl-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide;
3-Chloro-N-(5-cyclopropylmethoxymethyl-pyridin-2-yl)-benzenesulfonamide;
2,4-Dichloro-N-(5-cyclopropylmethoxymethyl-pyridin-2-yl)-6-methyl-benzenesulfonamide;
N-(5-Cyclopropylmethoxylnethyl-pyridin-2-yl)-4-fluoro-3-trifluoromethyl-benzenesulfonamide;
3 -Chloro-N-(5 -cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-benzenesulfonamide;
2,4-Dichloro-N-(5-cyclopropybnethoxymethyl-6-methyl-pyridin-2-yl)-6-methyl-benzenesulfonamide;
N-(5-Cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide;
2,4-Difluoro-N-[6-(3-fluoro-benzyloxymethyl)-pyridin-2-yl]-benzenesulfonamide;
3-Chloro-N-[6-(3-fluoro-benzyloxymethyl)-pyridin-2-yl]-benzenesulfonamide;
2,4-Dichloro-N-[6-(3-fluoro-benzyloxymethyl)-pyridin-2-yl]-6-methyl-benzenesulfonamide;
2,4-Difluoro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-benzenesulfonamide;
3-Chloro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-benzenesulfonamide;
2,4-Dichloro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-6-methyl-benzenesulfonamide;
N-(5-Cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-4-fluoro-3-trifluoromethyl-benzenesulfonamide;
4-Fluoro-N-[6-(3-fluoro-ben2yloxymethyl)-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide;
4-Fluoro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide;
N-[6-(4-Fluoro-benzyloxymethyl)-pyridin-2-yl]-3-trifluoromethoxy-benzenesulfonamide;
N-(6-Methoxymethyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide;
2,4-Dichloro-N-(6-methoxymethyl-pyridin-2-yl)-6-methyI-benzenesulfonamide;
3-Chloro-N-(6-methoxymethyl-pyridin-2-yl)-benzenesulfonamide;
3-Trifluoromethyl-N-[6-(3,3,3-trifluoro-propoxymethyl)-pyridin-2-yl]-benzenesulfonamide;
2,4-Dichloro-6-methyl-N-[6-(3,3,3-trifluoro-propoxymethyl)-pyridin-2-yl]-benzenesulfonamide;
N-[6-(2,2,2-Trifluoro-ethoxymethyl)-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide;
2,4-Dichloro-6-methyl-N-[6-(2,2,2-trifluoro-ethoxymethyl)-pyridin-2-yl]-benzenesulfonamide;
3-Chloro-N-[6-(2-cyclopropyl-ethoxymethyl)-pyridin-2-yl]-benzenesulfonamide;
N-[6-(2-Cyclopropyl-ethoxymethyl)-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide;
N-[6-(2-Cyclopropyl-ethoxymethyl)-pyridin-2-yl]-4-fluoro-3-trifluoromethyl-benzenesulfonamide;
2,4-Dichloro-N-[6-(2-cyclopropyl-ethoxymethyl)-pyridin-2-yl]-6-methyl-benzenesulfonamide;
2,4-Dichloro-5-methyl-N-[6-(2,2,2-trifluoro-ethoxymethyl)-pyridin-2-yl]-benzenesulfonamide;
2-Chloro-N-[6-(2,2,2-trifluoro-ethoxymethyl)-pyridin-2-yl]-5-trifluoromethyl-benzenesulfonamide;
2,4-Dichloro-N-[6-(3-chloro-benzyloxymethyl)-pyridin-2-yl]-6-methyl-benzenesulfonamide;
N-[6-(3-Chloro-benzyloxymethyl)-pyridin-2-yl]-4-fluoro-3-trifluoromethyl-benzenesulfonamide;
N-[6-(4-Chloro-benzyloxymethyl)-pyridin-2-yl] -4-fluoro-3 -trifluoromethyl-benzenesulfonamide;
2,4-Dichloro-N-[6-(4-chloro-benzyloxymethyl)-pyridin-2-yl]-6-methyl-benzenesulfonamide;
N-[5-(2,2,2-Trifluoro-ethoxymethyl)-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide;
2,4-Dichloro-5-methyl-N-[5-(2,2,2-trifluoro-ethoxymethyl)-pyridin-2-yl]-benzenesulfonamide;
3-Chloro-2-methyl-N-(3,4,5,6-tetrahydro-2H-[l,3']bipyridinyl-6'-yl)-benzenesulfonatnide;
3-Chloro-2-methyl-N-(5-pyrrolidin-l-yl-pyridin-2-yl)-benzenesulfonamide;
3-Chloro-2-methyl-N-(5-morpholin-4-yl-pyridin-2-yl)-benzenesulfonamide;
N-(5-Benzyl-pyridin-2-yl)-3-chloro-2-methyl-benzenesulfonamide;
3-Chloro-2-methyl-N-(5-phenethyl-pyridin-2-yl)-benzenesulfonamide;
3-Chloro-2-methyl-N-(6-methyl-5-phenethyl-pyridin-2-yl)-benzenesulfonamide;
3-Chloro-2-methyl-N-(5-thiomorpholin-4-yl-pyridin-2-yl)-benzenesulfonamide;
2,4-Dichloro-N-{5-[2-(4-chloro-phenyl)-ethyl]-pyridin-2-yl}-6-methyl-benzenesulfonamide;
3-Chloro-N-{5-[2-(4-methoxy-phenyl)-ethyl]-pyridin-2-yl}-2-methyl-benzenesulfonamide;
3-Chloro-N- {5-[2-(3-fluoro-phenyl)-ethyl]-pyridin-2-yl} -2-methyl-benzenesulfonamide;
3-Chloro-2-methyl-N-{5-[2-(2-trifluoromethyl-phenyl)-ethyl]-pyridin-2-yl}-benzenesulfonatnide
3-Chloro-N-{5-[2-(4-fluoro-phenyl)-ethyl]-pyridin-2-yl}-2-methyl-benzenesulfonamide;
3-Chloro-2-methyl-N-(5-phenoxy-pyridin-2-yl)-benzenesulfonamide;
3-Chloro-N-[5-(2-chloro-phenoxy)-pyridin-2-yl]-2-methyl-benzenesulfonamide;
3-Chloro-N-[5-(4-fluoro-phenoxy)-pyridin-2-yl]-2-methyl-benzenesulfonamide;
2,4-Dichloro-6-methyl-N-(5-phenoxy-pyridin-2-yl)-benzenesulfonamide;
2,4-Dichloro-N-[5-(2-chloro-phenoxy)-pyridin-2-yl]-6-methyl-benzenesulfonamide;
2,4-Dichloro-N-[5-(4-fluoro-phenoxy)-pyridin-2-yl]-6-methyl-benzenesulfonamide;
3-Chloro-2-methyl-N-[5-(2-quinolin-2-yl-ethyl)-pyridin-2-yl]-benzenesulfonamide;
2,4-Dichloro-6-methyl-N-[5-(2-quinolin-2-yl-ethyl)-pyridin-2-yl]-benzenesulfonamide; and
3-Chloro-2-methyl-N-[5-(2-pyridin-2-yl-ethyl)-pyridin-2-yl]-benzenesulfonamide. 12. The compounds as claimed in any one of claims 1 to 11 selected from
3-Chloro-N-(6-ethyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;
Biphenyl-4-sulfonic acid (6-propyl-pyridin-2-yl)-amide;
3-Chloro-2-methyl-N-(6-propyl-pyridin-2-yl)-benzenesulfonamide;
2,4-Dichloro-6-methyl-N-(6-propyl-pyridin-2-yl)-benzenesulfonamide;
5-Chloro-naphthalene-2-sulfonic acid (6-propyl-pyridin-2-yl)-amide;
3-Chloro-N-(6-isopropyl-pyridin-2-yl)-4-methyl-benzenesulfonamide;
N-(6-Isopropyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide;
3-Chloro-2-methyl-N-[6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-benzenesulfonamide;
2,5-Difluoro-N-[6-(4-fluoro-2-methyl-phenyl)-pyridin-2-yl]-benzenesulfonamide;
2,4-Dichloro-N-[6-(4-fluoro-2-methyl-phenyl)-pyridin-2-yl]-6-methyl-benzenesulfonamide;
2-[6-(3-Chloro-2-methyl-benzenesulfonylamino)-pyridin-2-yl]-N,N-diethyl-acetamide;
3-Chloro-N-(6-hydroxymethyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;
3-Chloro-N-(6-methoxymethyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;
3-Chloro-N-(6-cyclopropylmethoxymethyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;
3,4-Dichloro-N-(6-cyclopropylmethoxymethyl-pyridin-2-yl)-benzenesulfonamide;
4-Fluoro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-benzenesulfonamide;
N-[6-(4-Fluoro-benzyloxymethyl)-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide;
3 -Chloro-N-(5 -cyclopropylmethoxymethyl-pyridin-2- yl )-2-methyl-benzenesulfonamide;
3-Chloro-N-(5-cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;
3-Chloro-N-(5-methoxymethyl-6-methyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;
N-(5-Ethoxymethyl-6-methyl-pyridin-2-yl)-3-trifluoromethylbenzenesulfonamide;
3-Chloro-N-(6-cyclopropyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;
Naphthalene-1-sulfonic acid (6-cyclopropyl-pyridin-2-yl)-amide;
4-Chloro-N-(6-cyclopropyl-pyridin-2-yI)-2,5-dimethyl-benzenesulfonamide;
N-(6-Cyclopropyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide;
N-(5-Cyclopropylmethoxymethyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide;
4-Chloro-N-(5-ethoxymethyl-6-methyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide;
2,4-Dichloro-N-(5-cyclopropylmethoxymethyl-pyridin-2-yl)-6-methyl-benzenesulfonamide;
N-(5-Cyclopropylmethoxymethyl-pyridin-2-yl)-4-fluoro-3-trifluoromethyl-benzenesulfonamide;
2,4-Dichloro-N-(5-cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-6-methyl-benzenesulfonamide;
N-(5-Cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide;
2,4-Dichloro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-6-methyl-benzenesulfonamide;
4-Fluoro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide;
N-[6-(4-Fluoro-benzyloxymethyl)-pyridin-2-yl]-3-trifluoromethoxy-benzenesulfonamide;
N-(6-Methoxymethyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide;
3-Trifluoromethyl-N-[6-(3,3,3-trifluoro-propoxymethyl)-pyridin-2-yl]-benzenesulfonamide;
2,4-Dichloro-6-methyl-N-[6-(3,3,3-trifluoro-propoxymethyl)-pyridin-2-yl]-benzenesulfonamide;
2,4-Dichloro-6-methyl-N-[6-(2,2,2-trifluoro-ethoxymethyl)-pyridin-2-yl]-benzenesulfonamide;
2,4-Dichloro-N-[6-(2-cyclopropyl-ethoxymethyl)-pyridin-2-yl]-6-methyl-benzenesulfonamide;
2,4-Dichloro-N-[6-(3-chloro-benzyloxymethyl)-pyridin-2-yl]-6-methyl-benzenesulfonamide;
N-[6-(4-Chloro-benzyloxymethyl)-pyridin-2-yl]-4-fluoro-3-trifluoromethyl-benzenesulfonamide;
2,4-Dichloro-N-[6-(4-chloro-benzyloxymethyl)-pyridin-2-yl]-6-methyl-benzenesulfonamide;
3-Chloro-2-methyl-N-(3,4,5,6-tetrahydro-2H-[1,3']bipyridinyl-6'-yl)-benzenesulfonamide;
3-Chloro-2-methyl-N-(5-pyrrolidin-l-yl-pyridin-2-yl)-benzenesulfonatnide;
3-Chloro-2-methyl-N-(5-morpholin-4-yl-pyridin-2-yl)-benzenesulfonamide;
N-(5-Benzyl-pyridin-2-yl)-3-chloro-2-methyl-benzenesulfonamide;
nyl-N-(6-methyl-5-phenethyl-pyridin-2-yl)-benzenesulfonamide;
nyl-N-(5-thiomorpholin-4-yl-pyridin-2-yl)-benzenesulfonamide;
{5-[2-(4-chloro-phenyl)-ethyl]-pyridin-2-yl}-6-methyl-mnide;
[2-(3-fluoro-phenyl)-ethyl]-pyridin-2-yl} -2-methyl-mide;
[2-(4-fluoro-phenyl)-ethyl] -pyridin-2-yl} -2-methyl-mide;
nyl-N-(5-phenoxy-pyridin-2-yl)-benzenesulfonamide;
[2-chloro-phenoxy)-pyridin-2-yl]-2-methyl-benzenesulfonamide;
[4-fluoro-phenoxy)-pyridin-2-yl]-2-methyl-benzenesulfonamide;
methyl-N-(5-phenoxy-pyridin-2-yl)-benzenesulfonamide;
-[5-(2-chloro-phenoxy)-pyridm-2-yl]-6-methyl mide; and
-[5-(4-fluoro-phenoxy)-pyridin-2-yl]-6-methyl-mide.
the preparation of a compound as claimed in any one of claims 1 to compound according to formula
(Formula Removed)
of a compound according to formula
3-Chloro-2-methyl-N-(6-methyl-5-phenethyl-pyridin-2-yl)-benzenesulfonamide;
3-Chloro-2-methyl-N-(5-thiomorpholin-4-yl-pyri(iin-2-yl)-benzenesulfonamide;
2,4-Dichloro-N-{5-[2-(4-chloro-phenyl)-ethyl]-pyridin-2-yl}-6-methyl-benzenesulfonamide;
3-Chloro-N-{5-[2-(3-fluoro-phenyl)-ethyl]-pyridin-2-yl}-2-methyl-benzenesulfonamide;
3-Chloro-N-{5-[2-(4-fluoro-phenyl)-ethyl]-pyridin-2-yl}-2-methyl-benzenesulfonamide;
3-Chloro-2-methyl-N-(5-phenoxy-pyridin-2-yl)-benzenesulfonamide;
3-Chloro-N-[5-(2-chloro-phenoxy)-pyridin-2-yl]-2-methyl-benzenesulfonamide;
3-Chloro-N-[5-(4-fluoro-phenoxy)-pyridin-2-yl]-2-methyl-benzenesulfonamide;
2,4-Dichloro-6-methyl-N-(5-phenoxy-pyridin-2-yl)-benzenesulfonamide;
2,4-Dichloro-N-[5-(2-chloro-phenoxy)-pyridin-2-yl]-6-methyl benzenesulfonamide; and
2,4-Dichloro-N-[5-(4-fluoro-phenoxy)-pyridin-2-yl]-6-methyl-benzenesulfonamide.
13. A process for the preparation of a compound as claimed in any one of claims 1 to 12 comprising
a) reaction of a compound according to formula
(Formula Removed)
in the presence of a compound according to formula
(Formula Removed)
in order to obtain a compound of the formula
(Formula Removed)
and optionally
b) further reaction in the presence of a compound of the formula R6-X in order to obtain a compound of the formula
(Formula Removed)
wherein R1 to R6 are defined as in claim 1 and X is C1, Br or 1.
14. The compounds as claimed in any one of claims 1 to 12 for use as therapeutically active substance.

Documents:

2966-DELNP-2007-Abstract-(10-01-2012).pdf

2966-delnp-2007-abstract.pdf

2966-delnp-2007-assignment.pdf

2966-DELNP-2007-Claims-(10-01-2012).pdf

2966-delnp-2007-claims.pdf

2966-DELNP-2007-Correspondence Others-(10-01-2012).pdf

2966-delnp-2007-correspondence-others-1.pdf

2966-delnp-2007-correspondence-others.pdf

2966-DELNP-2007-Description (Complete)-(10-01-2012).pdf

2966-delnp-2007-description (complete).pdf

2966-DELNP-2007-Form-1-(10-01-2012).pdf

2966-delnp-2007-form-1.pdf

2966-delnp-2007-form-18.pdf

2966-DELNP-2007-Form-2-(10-01-2012).pdf

2966-delnp-2007-form-2.pdf

2966-DELNP-2007-Form-3-(10-01-2012).pdf

2966-delnp-2007-form-3.pdf

2966-delnp-2007-form-5.pdf

2966-delnp-2007-gpa.pdf

2966-delnp-2007-pct-210.pdf

2966-delnp-2007-pct-304.pdf

2966-delnp-2007-pct-409.pdf

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Patent Number 251671
Indian Patent Application Number 2966/DELNP/2007
PG Journal Number 13/2012
Publication Date 30-Mar-2012
Grant Date 27-Mar-2012
Date of Filing 20-Apr-2007
Name of Patentee F.HOFFMANN-LA ROCHE AG
Applicant Address GRENZACHERSTRASSE 124,CH-4070 BASEL (CH)
Inventors:
# Inventor's Name Inventor's Address
1 KUHN,BERND SONNMATTWEG 42, CH-4410 LIESTAL, SWITZERLAND
2 MAYWEG, ALEXANDER MARTINSGASSE 8, CH-4051 BASEL, SWITZERLAND
3 NEIDHART, WERNER 9, RUE DU STEINLER, F-68220 HAGENTHAL-LE-BAS, FRANCE
4 AMREIN,KURT LETTENWEG 8,CH-4452 ITINGEN, SWITZERLAND.
5 HUNZIKER, DANIEL BUERKLISTRASSE 14, CH-4313 MOEHLIN, SWITZERLAND
PCT International Classification Number C07D 213/76
PCT International Application Number PCT/EP2005/010372
PCT International Filing date 2005-09-26
PCT Conventions:
# PCT Application Number Date of Convention Priority Country
1 04104856.2 2004-10-04 EUROPEAN UNION