| Title of Invention | DIMERIC IAP INHIBITORS |
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| Abstract | Molecular mimics of Smac are capable of modulating apoptosis through their interaction with cellular IAPs (inhibitor of apoptosis proteins). The mimetics are based on a monomer or dimer of the N-terminal tetrapeptide of IAP-binding proteins, such as Smac/DIABLO, Hid, Grim and Reaper, which interact with a specific surface groove of IAP. Also disclosed are methods of using these peptidomimetics for therapeutic purposes. In various embodiments of the invention the Smac mimetics of the invention are combined with chemotherapeutic agents, including, but not limited to topoisomerase inhibitors, kinase inbhibitors, NSAIDs, taxanes and platinum containing compounds use broader language. |
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1274-mumnp-2007-(diagram)-1.doc
1274-MUMNP-2007-ABSTRACT(08-11-2010).pdf
1274-mumnp-2007-abstract(22-5-2007).pdf
1274-mumnp-2007-claims(22-5-2007).pdf
1274-MUMNP-2007-CLAIMS(AMENDED)(26-3-2012).pdf
1274-MUMNP-2007-CLAIMS(AMENDED)-(08-11-2010).pdf
1274-MUMNP-2007-CLAIMS(AMENDED)-(13-2-2009).pdf
1274-MUMNP-2007-CLAIMS(AMENDED)-(20-9-2011).pdf
1274-MUMNP-2007-CLAIMS(MARKED COPY)(26-3-2012).pdf
1274-MUMNP-2007-CLAIMS(MARKED COPY)-(20-9-2011).pdf
1274-MUMNP-2007-COPY OF CLAIMS(26-3-2012).pdf
1274-MUMNP-2007-CORRESPONDENCE(08-11-2010).pdf
1274-MUMNP-2007-CORRESPONDENCE(10-1-2012).pdf
1274-mumnp-2007-correspondence(14-9-2007).pdf
1274-MUMNP-2007-CORRESPONDENCE(17-11-2011).pdf
1274-MUMNP-2007-CORRESPONDENCE(29-12-2011).pdf
1274-MUMNP-2007-CORRESPONDENCE(3-9-2012).pdf
1274-MUMNP-2007-CORRESPONDENCE(30-3-2009).pdf
1274-mumnp-2007-correspondence-others.pdf
1274-mumnp-2007-correspondence-received.pdf
1274-mumnp-2007-description (complete).pdf
1274-mumnp-2007-description(complete)-(22-5-2007).pdf
1274-MUMNP-2007-FORM 1(13-2-2009).pdf
1274-MUMNP-2007-FORM 1(17-11-2011).pdf
1274-mumnp-2007-form 13(08-11-2010).pdf
1274-mumnp-2007-form 13(13-2-2009).pdf
1274-MUMNP-2007-FORM 13(17-11-2011).pdf
1274-MUMNP-2007-FORM 18(13-2-2009).pdf
1274-mumnp-2007-form 2(22-5-2007).pdf
1274-MUMNP-2007-FORM 2(TITLE PAGE)-(13-2-2009).pdf
1274-mumnp-2007-form 2(title page)-(22-5-2007).pdf
1274-MUMNP-2007-FORM 3(20-9-2011).pdf
1274-MUMNP-2007-FORM 3(30-3-2009).pdf
1274-mumnp-2007-form-13(13-2-2009).pdf
1274-MUMNP-2007-OTHER DOCUMENT(29-12-2011).pdf
1274-mumnp-2007-pct-search report.pdf
1274-MUMNP-2007-PETITION UNDER RULE-137(26-3-2012).pdf
1274-mumnp-2007-power of attorney(14-9-2007).pdf
1274-MUMNP-2007-POWER OF ATTORNEY(20-9-2011).pdf
1274-MUMNP-2007-POWER OF ATTORNEY(26-3-2012).pdf
1274-MUMNP-2007-REPLY TO EXAMINATION REPORT(20-9-2011).pdf
1274-MUMNP-2007-REPLY TO HEARING(26-3-2012).pdf
1274-MUMNP-2007-SPECIFICATION(AMENDED)(26-3-2012).pdf
1274-MUMNP-2007-SPECIFICATION(AMENDED)-(08-11-2010).pdf
1274-MUMNP-2007-WO INTERNATIONAL PUBLICATION REPORT A3(08-11-2010).pdf
1274-mumnp-2007-wo international publication report(14-9-2007).pdf
| Patent Number | 251806 | ||||||||||||||||||||||||
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| Indian Patent Application Number | 1274/MUMNP/2007 | ||||||||||||||||||||||||
| PG Journal Number | 15/2012 | ||||||||||||||||||||||||
| Publication Date | 13-Apr-2012 | ||||||||||||||||||||||||
| Grant Date | 04-Apr-2012 | ||||||||||||||||||||||||
| Date of Filing | 22-Aug-2007 | ||||||||||||||||||||||||
| Name of Patentee | TETRALOGIC PHARMACEUTICALS CORPORATION | ||||||||||||||||||||||||
| Applicant Address | 343 PHOENIXVILLE PIKE, MALVERN, PENNSYLVANIA 19355 (US) | ||||||||||||||||||||||||
Inventors:
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| PCT International Classification Number | C07D209/20 | ||||||||||||||||||||||||
| PCT International Application Number | PCT/US2006/007068 | ||||||||||||||||||||||||
| PCT International Filing date | 2006-02-27 | ||||||||||||||||||||||||
PCT Conventions:
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