Title of Invention	PURIFICATION OF 2,6-DIISOPROPYL PHENOL
Abstract	The present invention relates to the process of purification of 2,6-diisopropyl phenol, the process of purification of 2,6-diisopropyl phenol by treating raw 2,6-diisopropyl phenol with solution of alkali metal soluble in alcohols at 0˚C to 5˚C, charging with solvents, washing with organic non-polar solvents, treating with dilute acids and finally extracting pure 2,6-diisopropyl phenol with organic non-polar solvent and purifying by distillation.

Title of Invention

PURIFICATION OF 2,6-DIISOPROPYL PHENOL

Abstract

The present invention relates to the process of purification of 2,6-diisopropyl phenol, the process of purification of 2,6-diisopropyl phenol by treating raw 2,6-diisopropyl phenol with solution of alkali metal soluble in alcohols at 0˚C to 5˚C, charging with solvents, washing with organic non-polar solvents, treating with dilute acids and finally extracting pure 2,6-diisopropyl phenol with organic non-polar solvent and purifying by distillation.

Full Text	FORM 2 THE PATENTS ACT, 1970 (39 of 1970) and THE PATENTS RULES, 2003 COMPLETE SPECIFICATION [See section 10 and rule 13] 1. Title: Purification of 2,6-diisopropyl phenol. 2. Applicant: Claris Lifesciences Limited, Claris Corporate Headquarters, Nr.Parimal Crossing, Ellisbridge, Ahmedabad-380 006, Gujarat, India. The following specification particularly describes the invention and the manner in which it is to be performed. Description Field of Invention: 5 The objective of the present invention is a process for the purification of 2,6-diisopropyl phenol. 2,6-diisopropyl phenols, i.e. propofol is a pharmaceutically important compound, which is used in anesthesia. The purity requirements of the agent for intra-vascular 10 administration are very high, and the aim is to obtain a high purity of 2,6-diisopropyl phenol. The process for the purification of raw 2,6-diisopropyl phenol obtaining pure 2,6-diisopropyl phenol, by treating raw 2,6-diisopropyl 15 phenol with an a alkali metal soluble in alcohol at 0°C to 5°C followed by distillation and charging a solvent for the removal of traces of alcohols and impurities, washing with non-polar solvent and finally neutralization of 2,6-diisopropyl phenol with acids, extracting with a solvent, and purified by fractional distillation. 20 Background of the invention US 5,591,311 discloses a purification method of raw 2,6-Diisopropyl phenol by dissolving the raw 2,6-Diisopropyl phenol in hydroxide solution 25 followed by heating, neutralizing with an inorganic acid such as sulfuric 2 acid or phosphoric acid, extracting with an organic solvent, and finally purifying by distillation. US 5,175,376 discloses purification method of raw 2,6-diisopropyl phenol 5 by crystallizing at very low temperature in presence of, or without solvent, crystals are filtered and washed with petroleum ether, which according to the disclosure of the cited document, 60g of 2,6-Diisopropyl phenol with a purity of at least 99.9% starting from lOOg of raw 2,6-Diisopropyl phenol can be obtained. 10 US 5,589,598 disclose purification method of 2,6-diisopropyl phenol by transformation of the crude 2,6-Diisopropyl phenol into its ester with a carboxylic or sulfonic acid, crystallization and hydrolysis with potassium hydroxide. 15 US 5,696,300 disclose purification of raw 2,6-diisopropyl phenol, reacting raw 2,6-Diisopropyl phenol with alkaline agent, isolation of the alkaline metal salt and by neutralization with acid. 20 CN 1109044 discloses purification of raw 2,6-diisopropyl phenol with a high efficiency distillation, refluxing in vacuum at 98°C to 156°C. KR 2000/047,871 disclose purification of raw 2,6-diisopropyl phenol by treating firstly with an inorganic acid and secondly with a base, extracting 3 with a solvent and purifying the distillation or crystallization at -20°C to -30°C. 5 Summary of the invention Accordingly, an objective of the present invention is to provide an industrially advantageous method of purification of 2,6-diisopropyl phenol with extremely high purity. 10 According to the present invention a process of purification has been developed, which is based on the reaction of raw 2,6-diisopropyl phenol with solution of alkali metal soluble in alcohol at 0°C to 5°C. Alkaline salt of 2,6-diisopropyl phenol is charged with solvent for the removal of the 15 trace alcohols and impurity, washing with non-polar solvent and finally neutralization of 2,6-diisopropyl phenol with acids, extracting with a solvent, and purified by fractional distillation. Detailed Description 20 The present invention is purification of raw 2,6-diisopropyl phenol which undergoes a series of sequential treatment, firstly raw 2,6-diisopropyl phenol is reacted with solution of alkali metal soluble in alcohols at 0°C to 5°C and followed by distillation, secondly alkaline salt 25 2,6-diisopropyl phenol is charged with solvents to removal of traces 4 alcohols and impurities, washing with non-polar solvent and finally neutralization of alkaline salt 2,6-diisopropyl phenol with acids and purified by filtration and distillation. The present embodiment of the purification of the raw 2,6-5 diisopropyl phenol is as under: The method in the present invention, raw 2,6-diisopropyl phenol is cooled at 0°C to 5°C as soon the temperature is attained solid 2,6-diisopropyl phenol start depositing. Slowly add the solution of alkali metal dissolved in alcohols to raw 2,6-diisopropyl phenol, wherein alkali metal 10 is selected from the group consisting of sodium and potassium, alcohols is selected from the group consisting of methanol, ethanol. The reaction was carried out at 0°C to 5°C, reaction mixture was stirred for 1 to 4 hours. Degas or distill out the alcohols and other impurity from alkaline salt of 2,6-diisopropyl phenol. 15 Alkaline salt of 2,6-diisopropyl phenol was charged with solvent selected from the group consisting of hexane, petroleum ether, heptane and mixture thereof for removal of traces of alcohols and impurities. Stir the reaction mix for about 1 hour. Distill out the solvent from the reaction mixture until the dry powder of the alkaline salt of 2,6-diisopropyl phenol 20 is formed. Alkaline salt of 2,6-diisopropyl phenol thus obtained was washed with chilled non-polar organic solvent selected from the group consisting of hexane, heptane, chloroform, petroleum ether, methylene-chloride toluene and mixture thereof, stir for 10 to 15 minute and filter out the 5 solvent. Thoroughly wash alkaline salt of 2,6-diisopropyl phenol with chilled non-polar organic solvent, thus obtained in pure state. Alkaline salt of 2,6-diisopropyJ phenol was charged with water and organic non-polar solvent. Solution is neutralized with dilute acids 5 selected from the group consisting of hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, methanesulfonic acid, and formic acid. Organic layer was separated from aqueous layer, and aqueous layer was extracted with an organic non-polar solvent selected from the group consisting of hexane, heptane, chloroform, petroleum ether, methylene- 10 chloride toluene and mixture thereof. The organic layer was washed with 10% sodium chloride. For removal of colour and impurity organic layer was treated with charcoal. The organic layer was subjected to fractional distillation for further purification. The final product (2,6-diisopropyl phenol) thus obtained in very pure form. 15 According to the present invention the alkaline salts of 2,6- diisopropyl phenol is insoluble in organic non-polar solvent and the impurity in raw 2,6-diisopropyl phenol gets dissolve in the organic non-polar solvent. Thus by filtration and washing with organic non-polar solvent, pure alkaline salt is neutralized with dilute acids and pure 2,6- 20 diisopropyl phenol is isolated by extraction with organic non-polar solvent and purified by fractional distillation. The following examples are intended to be illustrative for the present invention and should not be construed as limiting the scope of this invention defined by the appended claims. 6 Example 1 To 1.0 kg of Crude Propofol, previously cooled to 0°C-5°C, 1.5 Kg 25% solution of alkali metal soluble in alcohol are added during 90 minutes whereby maintaining the temperature followed by maintaining at the ambient temperature 5 for 150 minutes. Then methanol is distilled at 40-45°C until the white slurry remains, IIexane is added there into the slurry, stirred for 10 minutes and the solvent is distilled until dry powder remains. Add 2.0kg toluene to the dry power. The obtained a suspension, which is stirred for 30 minutes at 5° to 10°C. The sodium 2,6-diisopropylphenate thus obtained is filtered and washed with 10 anhydrous Toluene until it becomes white. The product, still wet of toluene, is added to a solution of 1.2 Lit of 37% Hydrochloric Acid in 1.2 kg of Water and the propofol is extracted with 3.0 Lit of toluene at 0° to 5°C, at a decidedly acid p]]. The organic phase is washed with a 10% 1.5 lit aqueous solution of sodium chloride, followed by the washing of organic layer by 1.0 Lit water. Then it is 15 distilled at about 600C. and at about 2.6 times. 10.sup.3 pascal until oil is obtained which, in its turn, is distilled under vacuum (about 1.7 times.10.sup.3 pascal) by eliminating the fraction boiling at 60° to 90°C. and recovering the product at 93° to 98°C. Thus, there is obtained 0.80 kg of pure propofol. 20 25 7 We claim, 1. A process for purification of 2,6 diisopropyl phenol, the said process comprises, a. Treatment of raw 2,6 diisopropyl phenol with solution of alkali 5 metal soluble in alcohol at 0°C to 5°C; b. Treatment of alkaline 2,6 diisopropyl phenol with solvent selected from the group consisting of hexane, petroleum ether, heptane and mixture thereof, for the removal of traces alcohols and impurities; 10 c. Washing alkaline 2,6 diisopropyl phenol with non polar solvents; d. Neutralization of 2,6 diisopropyl phenol with dilute acids; e. Extraction of pure 2,6 diisopropyl phenol with solvent and purified by distillation and crystallization. 15 2. A process according to claim 1, wherein the said alkali metal is selected from the group consists of sodium and potassium, and the said alcohol is selected from the group consists of methanol, ethanol. 3. A process according to claim 1, wherein the said non-polar solvents 20 is selected from the group consists of hexane, heptane, chloroform, petroleum ether, methylene chloride toluene and mixture thereof. 4. A process according to claim 1, wherein the said acids for the neutralization is selected from the group consists of hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, methanesulfonic 25 acid, and formic acid. 8 5. A process for the purification of 2,6 diisopropyl phenol where in a raw 2,6 diisopropyl phenol is treated with acid or base, salt of 2,6 diisopropyl is charged with solvent, washed with non-polar solvent and then neutralized with respective base or acids. 5 6. A process according to claim 5, treatment of salt of 2,6 diisopropyl phenol with solvent is selected from the group consists of hexane, petroleum ether, heptane and mixture thereof for the removal of trace alcohols and impurities. 7. A process according to claim 5, wherein the said acids is selected 10 from the group consists of hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, methanesulfonic acid, and formic acid. 8. A process according to claim 5, wherein the said base is selected from the group consists of alkali metals soluble in alcohol. 9. A process according to claim 8, wherein the said alkali metals are 15 sodium and potassium. 10. A process according to claim 5, wherein the said solvent is selected from the group consisting or hexane, heptane, chloroform, petroleum ether, methylene chloride, toluene and mixture 20 DATE and SIGNATURE Date : 03rd November 2008 Name : Chetan S. Majmudar Designation: Director 9 A \ /IK

Full Text

FORM 2
THE PATENTS ACT, 1970
(39 of 1970)
and
THE PATENTS RULES, 2003
COMPLETE SPECIFICATION
[See section 10 and rule 13]
1. Title: Purification of 2,6-diisopropyl phenol.

2. Applicant:

Claris Lifesciences Limited, Claris Corporate Headquarters, Nr.Parimal Crossing, Ellisbridge, Ahmedabad-380 006, Gujarat, India.

The following specification particularly describes the invention and the manner in
which it is to be performed.

Description
Field of Invention:
5
The objective of the present invention is a process for the purification of 2,6-diisopropyl phenol. 2,6-diisopropyl phenols, i.e. propofol is a pharmaceutically important compound, which is used in anesthesia. The purity requirements of the agent for intra-vascular 10 administration are very high, and the aim is to obtain a high purity of 2,6-diisopropyl phenol.
The process for the purification of raw 2,6-diisopropyl phenol obtaining pure 2,6-diisopropyl phenol, by treating raw 2,6-diisopropyl
15 phenol with an a alkali metal soluble in alcohol at 0°C to 5°C followed by distillation and charging a solvent for the removal of traces of alcohols and impurities, washing with non-polar solvent and finally neutralization of 2,6-diisopropyl phenol with acids, extracting with a solvent, and purified by fractional distillation.
20
Background of the invention
US 5,591,311 discloses a purification method of raw 2,6-Diisopropyl
phenol by dissolving the raw 2,6-Diisopropyl phenol in hydroxide solution
25 followed by heating, neutralizing with an inorganic acid such as sulfuric
2

acid or phosphoric acid, extracting with an organic solvent, and finally purifying by distillation.
US 5,175,376 discloses purification method of raw 2,6-diisopropyl phenol 5 by crystallizing at very low temperature in presence of, or without solvent, crystals are filtered and washed with petroleum ether, which according to the disclosure of the cited document, 60g of 2,6-Diisopropyl phenol with a purity of at least 99.9% starting from lOOg of raw 2,6-Diisopropyl phenol can be obtained.
10
US 5,589,598 disclose purification method of 2,6-diisopropyl phenol by transformation of the crude 2,6-Diisopropyl phenol into its ester with a carboxylic or sulfonic acid, crystallization and hydrolysis with potassium hydroxide.
15
US 5,696,300 disclose purification of raw 2,6-diisopropyl phenol, reacting raw 2,6-Diisopropyl phenol with alkaline agent, isolation of the alkaline metal salt and by neutralization with acid.
20 CN 1109044 discloses purification of raw 2,6-diisopropyl phenol with a high efficiency distillation, refluxing in vacuum at 98°C to 156°C.
KR 2000/047,871 disclose purification of raw 2,6-diisopropyl phenol by treating firstly with an inorganic acid and secondly with a base, extracting
3

with a solvent and purifying the distillation or crystallization at -20°C to -30°C.
5 Summary of the invention
Accordingly, an objective of the present invention is to provide an industrially advantageous method of purification of 2,6-diisopropyl phenol with extremely high purity.
10
According to the present invention a process of purification has been developed, which is based on the reaction of raw 2,6-diisopropyl phenol with solution of alkali metal soluble in alcohol at 0°C to 5°C. Alkaline salt of 2,6-diisopropyl phenol is charged with solvent for the removal of the
15 trace alcohols and impurity, washing with non-polar solvent and finally neutralization of 2,6-diisopropyl phenol with acids, extracting with a solvent, and purified by fractional distillation.
Detailed Description
20
The present invention is purification of raw 2,6-diisopropyl phenol which undergoes a series of sequential treatment, firstly raw 2,6-diisopropyl phenol is reacted with solution of alkali metal soluble in alcohols at 0°C to 5°C and followed by distillation, secondly alkaline salt 25 2,6-diisopropyl phenol is charged with solvents to removal of traces
4

alcohols and impurities, washing with non-polar solvent and finally neutralization of alkaline salt 2,6-diisopropyl phenol with acids and purified by filtration and distillation.
The present embodiment of the purification of the raw 2,6-5 diisopropyl phenol is as under:
The method in the present invention, raw 2,6-diisopropyl phenol is cooled at 0°C to 5°C as soon the temperature is attained solid 2,6-diisopropyl phenol start depositing. Slowly add the solution of alkali metal dissolved in alcohols to raw 2,6-diisopropyl phenol, wherein alkali metal
10 is selected from the group consisting of sodium and potassium, alcohols is selected from the group consisting of methanol, ethanol. The reaction was carried out at 0°C to 5°C, reaction mixture was stirred for 1 to 4 hours. Degas or distill out the alcohols and other impurity from alkaline salt of 2,6-diisopropyl phenol.
15 Alkaline salt of 2,6-diisopropyl phenol was charged with solvent
selected from the group consisting of hexane, petroleum ether, heptane and mixture thereof for removal of traces of alcohols and impurities. Stir the reaction mix for about 1 hour. Distill out the solvent from the reaction mixture until the dry powder of the alkaline salt of 2,6-diisopropyl phenol
20 is formed.
Alkaline salt of 2,6-diisopropyl phenol thus obtained was washed with chilled non-polar organic solvent selected from the group consisting of hexane, heptane, chloroform, petroleum ether, methylene-chloride toluene and mixture thereof, stir for 10 to 15 minute and filter out the
5

solvent. Thoroughly wash alkaline salt of 2,6-diisopropyl phenol with chilled non-polar organic solvent, thus obtained in pure state.
Alkaline salt of 2,6-diisopropyJ phenol was charged with water and organic non-polar solvent. Solution is neutralized with dilute acids 5 selected from the group consisting of hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, methanesulfonic acid, and formic acid. Organic layer was separated from aqueous layer, and aqueous layer was extracted with an organic non-polar solvent selected from the group consisting of hexane, heptane, chloroform, petroleum ether, methylene-
10 chloride toluene and mixture thereof. The organic layer was washed with 10% sodium chloride. For removal of colour and impurity organic layer was treated with charcoal. The organic layer was subjected to fractional distillation for further purification. The final product (2,6-diisopropyl phenol) thus obtained in very pure form.
15 According to the present invention the alkaline salts of 2,6-
diisopropyl phenol is insoluble in organic non-polar solvent and the impurity in raw 2,6-diisopropyl phenol gets dissolve in the organic non-polar solvent. Thus by filtration and washing with organic non-polar solvent, pure alkaline salt is neutralized with dilute acids and pure 2,6-
20 diisopropyl phenol is isolated by extraction with organic non-polar solvent and purified by fractional distillation.
The following examples are intended to be illustrative for the present invention and should not be construed as limiting the scope of this invention defined by the appended claims.
6

Example 1
To 1.0 kg of Crude Propofol, previously cooled to 0°C-5°C, 1.5 Kg 25% solution of alkali metal soluble in alcohol are added during 90 minutes whereby maintaining the temperature followed by maintaining at the ambient temperature 5 for 150 minutes. Then methanol is distilled at 40-45°C until the white slurry remains, IIexane is added there into the slurry, stirred for 10 minutes and the solvent is distilled until dry powder remains. Add 2.0kg toluene to the dry power. The obtained a suspension, which is stirred for 30 minutes at 5° to 10°C. The sodium 2,6-diisopropylphenate thus obtained is filtered and washed with
10 anhydrous Toluene until it becomes white. The product, still wet of toluene, is added to a solution of 1.2 Lit of 37% Hydrochloric Acid in 1.2 kg of Water and the propofol is extracted with 3.0 Lit of toluene at 0° to 5°C, at a decidedly acid p]]. The organic phase is washed with a 10% 1.5 lit aqueous solution of sodium chloride, followed by the washing of organic layer by 1.0 Lit water. Then it is
15 distilled at about 600C. and at about 2.6 times. 10.sup.3 pascal until oil is obtained which, in its turn, is distilled under vacuum (about 1.7 times.10.sup.3 pascal) by eliminating the fraction boiling at 60° to 90°C. and recovering the product at 93° to 98°C. Thus, there is obtained 0.80 kg of pure propofol.
20
25
7

We claim,
1. A process for purification of 2,6 diisopropyl phenol, the said process comprises,
a. Treatment of raw 2,6 diisopropyl phenol with solution of alkali
5 metal soluble in alcohol at 0°C to 5°C;
b. Treatment of alkaline 2,6 diisopropyl phenol with solvent
selected from the group consisting of hexane, petroleum ether,
heptane and mixture thereof, for the removal of traces
alcohols and impurities;
10 c. Washing alkaline 2,6 diisopropyl phenol with non polar
solvents;
d. Neutralization of 2,6 diisopropyl phenol with dilute acids;
e. Extraction of pure 2,6 diisopropyl phenol with solvent and
purified by distillation and crystallization.
15 2. A process according to claim 1, wherein the said alkali metal is
selected from the group consists of sodium and potassium, and the said alcohol is selected from the group consists of methanol, ethanol.
3. A process according to claim 1, wherein the said non-polar solvents
20 is selected from the group consists of hexane, heptane, chloroform,
petroleum ether, methylene chloride toluene and mixture thereof.
4. A process according to claim 1, wherein the said acids for the
neutralization is selected from the group consists of hydrochloric
acid, acetic acid, sulphuric acid, phosphoric acid, methanesulfonic
25 acid, and formic acid.
8

5. A process for the purification of 2,6 diisopropyl phenol where in a
raw 2,6 diisopropyl phenol is treated with acid or base, salt of 2,6
diisopropyl is charged with solvent, washed with non-polar solvent
and then neutralized with respective base or acids.
5 6. A process according to claim 5, treatment of salt of 2,6 diisopropyl
phenol with solvent is selected from the group consists of hexane, petroleum ether, heptane and mixture thereof for the removal of trace alcohols and impurities.
7. A process according to claim 5, wherein the said acids is selected
10 from the group consists of hydrochloric acid, acetic acid, sulphuric
acid, phosphoric acid, methanesulfonic acid, and formic acid.
8. A process according to claim 5, wherein the said base is selected
from the group consists of alkali metals soluble in alcohol.
9. A process according to claim 8, wherein the said alkali metals are
15 sodium and potassium.
10. A process according to claim 5, wherein the said solvent is selected from the group consisting or hexane, heptane, chloroform, petroleum ether, methylene chloride, toluene and mixture
20
DATE and SIGNATURE
Date : 03rd November 2008

Name : Chetan S. Majmudar
Designation: Director
9
A \ /IK

Documents:

2424-MUM-2008-ABSTRACT(29-12-2011).pdf

2424-MUM-2008-ABSTRACT(6-6-2012).pdf

2424-MUM-2008-ABSTRACT(GRANTED)-(25-6-2012).pdf

2424-mum-2008-abstract.doc

2424-mum-2008-abstract.pdf

2424-mum-2008-assignment(18-11-2008).pdf

2424-mum-2008-assignment.pdf

2424-MUM-2008-CLAIMS(AMENDED)-(29-12-2011).pdf

2424-MUM-2008-CLAIMS(AMENDED)-(6-6-2012).pdf

2424-MUM-2008-CLAIMS(GRANTED)-(25-6-2012).pdf

2424-mum-2008-claims.doc

2424-mum-2008-claims.pdf

2424-MUM-2008-CORRESPONDENCE(12-12-2008).pdf

2424-MUM-2008-CORRESPONDENCE(IPO)-(25-6-2012).pdf

2424-mum-2008-correspondence.pdf

2424-mum-2008-description(complete).doc

2424-mum-2008-description(complete).pdf

2424-MUM-2008-DESCRIPTION(GRANTED)-(25-6-2012).pdf

2424-mum-2008-form 1.pdf

2424-MUM-2008-FORM 18(12-12-2008).pdf

2424-MUM-2008-FORM 2(GRANTED)-(25-6-2012).pdf

2424-MUM-2008-FORM 2(TITLE PAGE)-(29-12-2011).pdf

2424-MUM-2008-FORM 2(TITLE PAGE)-(6-6-2012).pdf

2424-MUM-2008-FORM 2(TITLE PAGE)-(GRANTED)-(25-6-2012).pdf

2424-mum-2008-form 2(title page).pdf

2424-mum-2008-form 2.doc

2424-mum-2008-form 2.pdf

2424-mum-2008-form 3.pdf

2424-mum-2008-form 5.pdf

2424-mum-2008-form 9(12-12-2008).pdf

2424-MUM-2008-REPLY TO EXAMINATION REPORT(29-12-2011).pdf

2424-MUM-2008-REPLY TO HEARING(6-6-2012).pdf

2424-MUM-2008-SPECIFICATION(AMENDED)-(29-12-2011).pdf

2424-MUM-2008-SPECIFICATION(AMENDED)-(6-6-2012).pdf

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Patent Number

253079

Indian Patent Application Number

2424/MUM/2008

PG Journal Number

26/2012

Publication Date

29-Jun-2012

Grant Date

25-Jun-2012

Date of Filing

18-Nov-2008

Name of Patentee

CLARIS LIFESCIENCES LIMITED

Applicant Address

CLARIS LIFESCIENCES LTD CLARIS CORPORATE HEADQUARTERS, NR. PARIMAL CROSSING, ELLISBRIDGE, AHMEDABAD-380006,

Inventors:

#	Inventor's Name	Inventor's Address
1	MAJMUDAR CHETAN S	CLARIS LIFESCIENCES LIMITED, CLARIS CORPORATE HEADQUARTERS, NR. PARIMAL CROSSING, ELLISBRIDGE, AHMEDABAD-380006,
2	CHAKRAVARTY PRADEEP	CLARIS LIFESCIENCES LIMITED, CLARIS CORPORATE HEADQUARTERS, NR. PARIMAL CROSSING, ELLISBRIDGE, AHMEDABAD-380006, INDIA
3	SONEJI DHAVAL J	CLARIS LIFESCIENCES LIMITED, CLARIS CORPORATE HEADQUARTERS, NR. PARIMAL CROSSING, ELLISBRIDGE, AHMEDABAD-380006, INDIA

PCT International Classification Number

C07C37/00

PCT International Application Number

N/A

PCT International Filing date

PCT Conventions:

#	PCT Application Number	Date of Convention	Priority Country
1			NA