Title of Invention	"PROCESS FOR THE PREPARATION OF THIOALKYLAMINE DERIVATIVES"
Abstract	A process for preparing compounds of formula (I) in which R1, R2, R3, R4, R5, R6 and n are as described in the specification and claims.

Full Text

The present invention relates to a novel process for the preparation of known thio-alkylamine derivatives. Because of their chemical structure thioalkylamine derivatives can be divided into two groups, thiols and sulphides. For the preparation of both classes the methods discussed below have been described. A first method for the preparation of thiols is based on the hydrolytic cleavage of thiazoline or thiazolidinone derivatives (cf. e.g. J. Med. Chem. 1965, 8, 762; JP 59-231064, Bull. Soc. Chim. Fr. 1967.3637). As thiazoline or thiazohdinone derivatives have to be prepared first via several reaction steps the overall yield of this method is very low. Thiols can be obtained furthermore by a process comprising reacting sulphates of amino alcohols with ammonium sulphide (cf. e.g. Nihon Kagaku Kaishi 1979. 149). This method requires long reactions times in a sealed reaction vessel, which causes high costs because of the required production plants having low productivity. The reaction of oxazoline- or oxazolidinone derivatives with thiols is a method for the preparation of sulphides (cf. e.g. J. Org. Chem. 1992. 57, 6257; J. Med. Chem. 1984. 27, 1354). A hydrolytic process is required to obtain reaction products as amides according to this method. However, no reaction is observed, if the oxazoli-dine ring of the starting compounds is e.g. alkyl substituted. Furthermore, only aromatic sulphides can be prepared using this method because of the acidity of the mercaptans. The hydrolytic cleavage of amides, which can be obtained by reaction of amino alcohols with mercaptans in the presence of carboxylic acids, also furnishes sulphides (cf. e.g. DE-OS 14 93 534). This method has to be carried out at high temperature and under pressure using long reaction times and is therefore restricted to the synthesis of sulphides. Additionally a hydrolytic step is required to obtain the reaction products from amides. The reaction of aziridines with sulphur compounds like mercaptans represents a method for preparing of sulphides and thiols (cf. e.g. Tetrahedron 1992, 48, 2359; Tetrahedron Lett. 1983, 24, 2131). High demands on safety requirements have to be made for industrial scale production using this method because highly toxic and possibly instable aziridines have to be prepared and isolated. A method for the conversion of thioalkylalcohols into thioalkylamines is represented by the Ritter reaction with subsequent hydrolytic cleavage (cf. e.g. DE-OS 20 45 905). This method employs hydrocyanic acid in excess, which must be handled with the utmost caution. In the case that nitriles which can be easily handled are employed the hydrolytic process causes problems. A further method for the preparation of thioalkylamine derivatives uses as starting material amino alcohols which are reacted with sulphuric acid to give the corresponding esters in a first step (cf. WO 01/23350). After evaporation to dryness this esters are further converted by reaction with mercaptans. The required evaporation after the .the first reaction step causes problems when this process is employed to a large scale production. US 5507840 describe the first step of the claimed process namely the preparation of amino sulphuric esters using oleum as sulphating agent. US 2769839 describe the reaction of marcaptohalides with ammonium. However, mercaptohalides are not subject matter of the present invention. We have now found that compounds of the formula (I) (Formula Removed) in which R1 and R2 in each case independently of one another represent hydrogen, C1-C4-alkyl, C3-C8-cycloalkyl, C3-C8-cycloalkyl-C1-C4-alkyl, hydroxy-C1-C4-alkyl; unsubstituted or mono- to pentasubstituted phenyl, where the substituents are identical or different and are selected from the group consisting of halogen, cyano, nitro, C1-C4-alkyl, C3-C8-cycloalkyl, C1-C4-aIkoxy, C1C4-alkylthio, C1-C4-alkylsulfinyl, C1-C4-alkylsulfonyl, halo-C1-C4-alkyl halo-C1-C4-alkoxy, halo-C1-C4-alkylthio, halo-C1-C4-alkylsulfinyl and halo-C1-C4-alkylsulfonyl; unsubstituted or mono- to pentasubstituted phenyl-C1-C4-alkyl, where the substituents are identical or different and are selected from the group consisting of halogen, cyano, nitro, C1-C4-alkyl, C3-C8-cycloalkyl, C1-C4-alkoxy, C1-C4-alkylthio, C1-C4-alkylsulfinyl, C1-C4-alkylsulfonyl, halo-C1-C4-alkyl, halo-C1-C4-alkoxy, halo-C1-C4-alkylthio, halo-C1-C4-alkylsulfinyl and halo-C1-C4-alkylsulfonyl, R represents unsubstituted or mono- or polysubstituted C1-C12-alkyl, where the substituents are identical or different and are selected from the group consisting of halogen, hydroxy, C1-C4-alkoxy, halo-C1-C4-alkoxy, C1-C4-alkylthio, C1-C4-alkylsulfinyl and C1-C4-alkylsulfonyl; unsubstituted or mono- or poly-substituted C3-C8-cycloalkyl or C3-C8-cycloalkyl-C1-C4-alkyl, where the sub-stituents are identical or different and are selected from the group consisting of halogen, C1-C4-alkyl and C1-C4-alkoxy; unsubstituted or mono- to penta-substituted phenyl, where the substituents are identical or different and are selected from the group consisting of halogen, C1-C6-alkyl C3-C8-cycloalkyl, C1-C4-alkoxy, halo-C1-C4-alkyl, halo-C1-C4-alkoxy; unsubstituted or mono-to pentasubstituted phenyl-C1-C4-alkyl, where the substituents are identical or different and are selected from the group consisting of halogen and C1-C4-alkyl; naphthyl; unsubstituted or mono- or polysubstituted heteroaryl, where the substituents are identical or different and are selected from the group consisting of halogen, C1-C4-alkyl, C1-C4-alkoxy, unsubstituted or mono- to pentasubstituted phenyl, where the substituents are identical or different and are selected from the group consisting of halogen and C1-C4-alkyl, n represents 1,2,3, 4, 5, 6,7 or 8, where the group C(R])R2 may be identical or different, when n is greater than 1, and when n represents 1, R1 and R2 furthermore together represent C2-C5-alkylene, . R1 furthermore represents together with R3 or R5 C3-C5-alkylene, R3 and R4 furthermore together represent C4-C6-alkylene, R3 and R5 furthermore together represent C2-C4-alkylene, R5 and R6 furthermore together represent C4-C6-alkylene, are obtained by reacting in a first step amino alcohols of the formula (II) Formula Removed) in which R1, R2, R3, R4, R5, R6 and n have the above given meanings, with oleum to give sulphuric acid esters of the general formula (III) (Formula Removed) in which R1, R2, R3, R4, R5, R6 and n have the above given meanings, and by reacting these sulphuric acid esters in a second step with mercaptans or salts thereof of the general formula (IV) (Formula Removed) in which R has the above given meanings, and M represents hydrogen, ammonium or an alkali metal atom, in the presence of a base and preferably in the presence of a diluent. Surprisingly, using the process according to the invention, the thioalkylamines of the formula (I) can be obtained in a simple manner in a very good space-time yield. The reaction according to the invention therefore has the advantage of an increased reaction rate. This leads to the technical advantage of a high space-time yield. The process according to the invention has the further advantage that the solution of the intermediates of formula (III) need not to be evaporated to dryness. The reaction mixture can be stirred at any time of the process which decreases the risk of a breaking reaction vessel in industrial plants. Detailed description of the process according to the invention The course of the reaction of the process according to the invention can be outlined by the following general reaction scheme: (Scheme Removed) The formula (H) provides a general definition of the amino alcohols required as starting materials for carrying out the first step of the process according to the invention. Preferred as starting material are amino alcohols of the formula (II), in which R1 and R2 in each case independently of one another represent hydrogen, C1-C4-alkyl, C3-C6-cycloalkyl, C3-C6-cycloalkyl-C1-C2-alkyl, hydroxy-C1-C4-alkyl; unsub-stituted or mono- to pentasubstituted phenyl, where the substituents are identical or different and are selected from the group consisting of fluorine, chlorine, bromine, iodine, cyano, nitro, C1-C4-alkyl, C3-C6-cycloalkyl, C1-C4-alkoxy, C1-C4-alkylthio, C1-C4-alkylsulfinyl, C1-C4-alkylsulfonyl, carboxyl, C1-C4-alkoxycarbonyl, C1-C4-alkoxy-C1-C4-alkyl, C1-C4-alkylcarbonyl, halo-C1-C4-alkyl, halo-C1-C4-alkoxy, halo-C1-C4-alkylthio, halo-C1-C4-alkylsulfi-nyl, halo-C1-C4-alkylsulfonyl, halo-C1-C4-alkylcarbonyl, each having 1 to 9 identical or different fluorine, chlorine and/or bromine atoms, phenylcarbonyl, phenoxycarbonyl, amino, C1-C4-alkylamino and di-(C1-C4-alkyl)-amino (where the alkyl groups can be identical or different); phenyl, which is substituted at two adjacent carbon atoms by C3-C4-alkylene or C1-C2-alkylenedioxy; unsubstituted or mono- to pentasubstituted phenyl-C1-C2-alkyl, where the substituents are identical or different and are selected from the group consisting of fluorine, chlorine, bromine, iodine, cyano, nitro, C1-C4-alkyl, C3-C6- cycloalkcyl, C1-C4-alkoxy, C1-C4-alkylthio, C1-C4-alkylsulfinyl3 C1-C4-alkyl-sulfonyl, halo-C1-C4-aIkyl, halo-C1-C4-alk:oxy, halo-C1-C4-alkythio, halo-C1-C4-alkylsulfinyl and hdo-C1-C4-alkylsulfonyl, each having 1 to 9 identical or different fluorine, chlorine and/or bromine atoms; R3 and R4 independently of one another represent hydrogen or C1-C4-aIkyl R5 and R6 independently of one another represent hydrogen, C1-C4-alkyl, unsubsti-tuted or mono- to pentasubstituted phenyl, where the substituents are identical or different and are selected from the group consisting of fluorine, chlorine, bromine, iodine, cyano, nitro, C1-C4-aliyl, C3-C6-cycloalkyl, C1-C4-alkoxy, C1-C4-alkylthio, C1-C4-alJkylsulfinyl, C1-C4-alkylsulfonyl halo-C1-C4-alkyl, halo-C1-C4-ali:oxy, halo-C1-C4-aIkylthio, halo-C1-C4-alkylsulfinyl and halo-C1-C4-alkylsulfonyl, each having 1 to 9 identical or different fluorine, chlorine and/or bromine atoms; unsubstituted or mono- to pentasubstituted phenyl-C1-C2-alkyl, where the substituents are identical or different and are selected from the group consisting of fluorine, chlorine, bromine, iodine, cyano, nitro, C1-C4-alkyl, C3-C8-cycloalkyl, C1-C4-alkoxy, C1-C4-allrylthio, C1-C4-alkyl-sulfinyl, C1-C4-alkylsulfonyl, halo-C1-C4-alkyl, halo-C1-C4-alkoxy, halo-C1-C4-alkylthio, halo-C1-C4-alkylsulfrnyl and halo-C1-C4-alkylsulfonyl, each having 1 to 9 identical or different fluorine, chlorine and/or bromine atoms; n represents 1, 2, 3, 4, 5 or 6, where the group C(R1)R2 may be identical or different, when n is greater than 1, and when n represents 1, R1 and R2 furthermore together represent C2-C5-alkylene, R1 furthermore represents together with R3 or R5 C3-C5-alkylene, R3 and R4 furthermore together represent C4-C6-alkylene, R and R furthermore together represent C2-C4-alkylene, R5andR furthermore together represent C4-C6-altylene. Particularly preferred as starting material are amino alcohols of the formula (II), in which R1 and R2 in each case independently of one another represent hydrogen, methyl, ethyl, n-, i-propyl, n-, i-, s-, t-butyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclobutylmethyl, cyclopentylmethyl, cyclo-hexyhnethyl, cyclopropylethyl, cyclobutylethyl, cyclopentylethyl, cyclohexyl-ethyl, hydroxymethyl, hydroxyethyl; unsubstituted or mono- to trisubstituted phenyl, where the substituents are identical or different and are selected from the group consisting of fluorine, chlorine, bromine, iodine, cyano, nitro, methyl, ethyl, n-, i-propyl, n-, i-3 s-, t-butyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, methoxy, ethoxy, n-, i-propoxy, n-, i-, s-, t-butoxy, methylthio, ethylthio, n-, i-propylthio, n-, i-, s-, t-butylthio, methylsulfinyl, ethylsulfinyl, n-, i-propylsulfinyl, n-, i-, s-, t-butylsulfinyl, methylsulfonyl, ethylsulfonyl, n-, i-propylsulfonyl, n-, i-, s-, t-butylsulfonyl, trifluoromethyl, trichloromethyl, difluoromethyl, dichloromethyl, difluorochloromethyl, fluorodichloromethyl, trifiuoromethoxy, trichloromethoxy, difluoromethoxy, dichloromethoxy, difluorochloromethoxy, fluorodichloromethoxy, trifluoro-methylthio, trichloromethylthio, difiuoromethylthio, dichloromethylthio, di-fluorochloromethylthio, fluorodichloromethylthio, trifluoromethylsulfinyl, tri-chloromethylsulfinyl, difluoromethylsulfinyl, dichloromethylsulfinyl, di-fluorochloromethylsulfinyl, fluorodichloromethylsulfinyl, trifluoromethylsul-fonyl, trichloromethylsulfonyl, difluoromethylsulfonyl, dichloromethylsul-fonyl, difluorochloromethylsulfonyl, fluorodichloromethylsulfonyl, trifluoro-methylcarbonyl, carboxyl, methoxycarbonyl, ethoxycarbonyl, methoxymethyl, ethoxyethyl, methoxyethyl, ethoxymethyl, methylcarbonyl, ethylcarbonyl, phenylcarbonyl, phenoxycafbonyl, amino, methylamino, emylarnino, propyl-amino, dimethylamino, diemylamino; phenyl, which is substituted at two adjacent carbon atoms by -(CH2)3-, -(CH2)4-, -OCH2O-5 -O(CH2)2O-; in each case unsubstituted or mono- to trisubstituted benzyl or phenylethyl, where in each case the substituents are identical or different and are selected from the group consisting of fluorine, chlorine, bromine, iodine, cyano, nitro, methyl, ethyl, n-, i-propyL n-, i-, s-, t-butyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, methoxy, ethoxy, n-, i-propoxy, n-, i-, s-, t-butoxy, methylthio, ethylthio, n-, i-propylthio, n-, i-, s-, t-butylthio, methylsulfinyl, ethylsulfinyi, n-, i-propylsulfinyl, n-, i-, s-, t-butylsulfinyl, methylsulfonyl, ethylsulfonyl, n-, i-propylsulfonyl, n-, i-, s-, t-butylsulfonyl, trifluoromethyl, trichloromethyl, difluoromethyl, dichloromethyl, difluorochloromethyl, fluorodichloromethyl, trifluoromethoxy, trichloromethoxy, difluoromethoxy, dichloromethoxy, di-fluorochloromethoxy, fluorodichloromethoxy, trifluoromethylthio, trichloro-methylthio, difluoromethylthio, dichloromethylthio, difluorochloromethyl-thio, fluorodichloromethylthio, trifluoromethylsulfinyl, trichloromethylsul-finyl, difluoromethyisulfinyl, dichloromethylsulfinyl, difluorochloromethyl-sulfinyl, fluorodichloromethylsulfinyl, trifluoromethylsulfonyl, trichlorome-thyisulfonyl, difluorome&ylsulfonyl, dichloromethylsulfonyl, difluorochloro-methylsulfonyl, fluorodichloromethylsulfonyl; R3 and R4 independently of one another represent hydrogen, methyl, ethyl, n-, i-propyl, n-, i-, s-, t-butyl, R5 and R6 independently of one another represent hydrogen, methyl, ethyl, n-, i-propyl, n-, i-, s-, t-butyl, unsubstituted or mono- to trisubstituted phenyl, where the substituents are identical or different and are selected from the group consisting of fluorine, chlorine, bromine, iodine, cyano, nitro, methyl, ethyl, n-, i-propyl, n-, i-, s-, t-butyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, methoxy, ethoxy, n-, i-propoxy, n-, i-, s-, t-butoxy, methylthio, ethyltbio, n-, i-propylthio, n-, i-, s-, t-butylthio, methylsulfinyl, ethylsulfinyi, n-, i-propyl-sulfinyl, n-, i-, s-, t-butylsulfinyl, methylsulfonyl, ethylsulfonyl, n-, i-propylsulfonyl, n-, i-, s-, t-butylsulfonyl, trifluoromethyl, trichloromethyl, difluoromethyi, dichloromethyl, difluorochloromethyl, fluorodichloromethyl, trifluoromethoxy, trichloromethoxy, difluoromethoxy, dichloromethoxy, di-fluorochloromethoxy, fluorodichloromethoxy, trifluoromethylthio, trichloro-methylthio, difluoromethylthio, dichloromethyltbio, difluorochloromethyl-thio, fluorodicliloromethylthio, trifluoromethylsulfinyl, trichloromethylsulfi- nyl, difluoromethylsulfinyl, dichloromethylsulfinyl, difluorochloromethylsul-finyi, fluorodichloromethylsulfinyl, trifluoromethylsulfonyl, trichloromethyl-sulfonyl, difluoromethylsulfonyl, dichloromethylsulfonyl, difluorochlorome-thylsulfonyl and fluorodichloromeftylsulfonyl; in each case unsubstituted or mono- to trisubstituted benzyl or phenylethyl, where in each case the substitu-ents are identical or different and are selected from the group consisting of fluorine, chlorine, bromine, iodine, cyano, nitro, methyl, ethyl, n-, i-propyl, n-, i-, s-, t-butyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, methoxy, ethoxy, n-, i-propoxy, n-, i-, s-, t-butoxy, methylthio, ethylthio, n-, i-propyl-thio, n-, i-, s-, t-butyltbio, methylsulfinyl, ethylsulfinyl, n-, i-propylsulfinyl, n-, i-, s-, t-butylsulfinyl, methylsulfonyl, ethylsulfonyl, n-, i-propylsulfonyl, n-, i-, s-, t-butylsulfonyl, trifluoromethyl, trichloromethyl, difluoromethyl, di-chloromethyl, difluorochloromethyl, fluorodichloromethyl, trifluoromethoxy, trichloromethoxy, difluoromethoxy, dichloromethoxy, difluorochloro-methoxy, fluorodichloromethoxy, trifluoromethylthio, trichloromethylthio, di-fluoromethylthio, dichloromethylthio, difluorochloromethylthio, fluorodi-chloromethylthio, trifluoromethylsulriayl, trichloromethylsulfinyl, difluoro-methylsulrinyl, dichloromethylsulfinyl, difluorochloromethylsulfinyl, fluoro-dichloromethylsulrinyl, trifluoromethylsulfonyl, trichloromethylsulfonyl, difluoromethylsulfonyl, dichloromethylsulfonyl, difluorochloromethylsulfonyl, fluorodichloromethylsulfonyl, n represents 1, 2, 3, 4, 5 or 6, where the group C(R1)R2 may be identical or different, when n is greater than 1, and when n represents 1, R1 and R2 furthermore together represent -(CH2)2-, -(CH2)3-, -(CH2)4-, -(CH2)5-, R1 furthermore represents together with R3 or R5 -(CH2)3-, -(CH2)4-, -(CH2)5-, R3 andR4 furthermore together represent -(CH2)4-, -(CH2)5-, -(CH2)e-, R3 and R5 furthermore together represent -(CH2)2-, -(CH2)3-, -(CH2)4-, R5 andR6 furthermore together represent -(CH2)4-, -(CH2)5-5 -(CH2)6-. Very particularly preferred as starting material are amino alcohols of the formula (II), in which R and R in each case independently of one another represent hydrogen, methyl, ethyl, n-, i-propyl, n-, i-, s-, t-butyl, cyclopropyl, cyclopentyl cyclohexyl, cyclopropylmethyl, cyclopentylmethyl, cyclohexylmethyl, hydroxymethyl, hydroxyethyl; unsubstituted or mono- to trisubstituted phenyl, where the substituents are identical or different and are selected from the group consisting of fluorine, chlorine, bromine, iodine, cyano, nitro, methyl, ethyl, n-, i-propyl, n-, i-, s-, t-butyl, cyclopropyl, cyclopentyl cyclohexyl, methoxy, ethoxy, n-, i-propoxy, n-, i-, s-, t-butoxy, methylthio, ethylthio, n-, i-pro-pylthio, n-, i-, s-, t-butylthio, methylsulfinyl, ethylsulfinyl, n-, i-propylsulfinyl, n-, i-, s-, t-butylsulfinyl, methylsulfonyl ethylsulfonyl, n-, i-propylsulfonyl n-, i-, s-, t-butylsulfonyl, trifluoromethyl, difluoromethyl, trifluoromethoxy, difluoromethoxy, trifluoromethylsulfinyl, trifluoromethylsulfonyl, rrifluoro-methylcarbonyl, carboxyl, methoxycarbonyL methoxymethyl, ethoxyethyl, methoxyethyL ethoxymethyl, methylcarbonyl, ethylcarbonyl, phenylcarbonyl, phenoxycarbonyl, amino, methylamino, emylamino, propylarnino, dimethyl-arnino, diethylamino; phenyl, which is substituted at two adjacent carbon atoms by -(CH2)3-, -(CH2)4-, -OCH2O-, -0(CH2)2O-; unsubstituted or mono-to trisubstituted benzyl, where the substituents are identical or different and are selected from the group consisting of halogen, cyano, nitro, methyl, ethyl, n-, i-propyl, n-, i-, s-, t-butyl, cyclopropyl, cyclopentyl, cyclohexyl, methoxy, ethoxy, n-, i-propoxy, n-, i-, s-, t-butoxy, methylthio, ethylthio, n-, i-pro-pylthio, n-, i-, s-, t-butylthio, methylsulfinyl, ethylsulfinyl, n-, i-propylsulfinyl, n-, i-, s-, t-butylsulfinyl, methylsulfonyl, ethylsulfonyl, n-, i-propylsulfonyl n-, i-, s-, t-butylsulfonyl, trifluoromethyl, difluoromethyl, trifluoromethoxy, difluoromethoxy, trifluoromethylsulfinyl, trifluoromethylsulfonyl; R and R independently of one another represent hydrogen, methyl, ethyl, n-, i-propyl, n-, i-, s-, t-butyl, R5 and R6 independently of one another represent hydrogen, methyl, ethyl, n-, i-propyl, n-, i-, s-, t-butyl, unsubstituted or mono- to trisubstituted phenyl, where the substituents are identical or different and are selected from the group consisting of fluorine, chlorine, bromine, iodine, cyano, nitro, methyl, ethyl, n-, i-propyl, n-, i-, s-, t-butyl, cyclopropyl, cyclopentyl, cyclohexyl, methoxy, ethoxy, n-, i-propoxy, n-, i-, s-, t-butoxy, methylthio, ethylthio, n-, i-propyl-thio, n-, i-, s-, t-butylthio, methylsulfinyl ethylsulfinyl, n-, i-propylsulfinyl n-, i-, s-, t-butylsulfinyl, methylsulfonyl, ethylsulfonyl, n-, i-propylsulfonyl, n-, i-, s-, t-butylsulfonyl, trifluoromethyl, difluoromethyl, trifluoromethoxy, difluoromethoxy, trifluoromethylsulfinyl, trifluoromethylsulfonyl; unsubstituted or mono- to trisubstituted benzyl, where the substituents are identical or different and are selected from the group consisting of fluorine, chlorine, bromine, iodine, cyano, nitro, methyl, ethyl, n-, i-propyl, n-, i-, s-, t-butyl, cyclopropyl, cyclopentyl, cyclohexyl, methoxy, ethoxy, n-, i-propoxy, n-, i-, s-, t-butoxy, methylthio, ethylthio, n-, i-propylthio, n-, i-, s-, t-butylthio, methylsulfinyl, ethylsulfinyl, n-, i-propylsulfinyl, n-, i-, s-, t-butylsulfinyl, methylsulfonyl, ethylsulfonyl, n-, i-propylsulfonyl, n-, i-, s-, t-butylsulfonyl, trifluoromethyl, difluoromethyl, trifluoromethoxy, difluoromethoxy, trifluoro-methylsulfinyl, trifluoromethylsulfonyl, n represents 1,2, 3 or 4, where the group CCR^R2 may be identical or different, when n is greater than 1, and when n represents 1, R1 and R2 furthermore together represent -(CH2)2-, -(CH2)3-, -(CH2)4-, -(CH2)5-, R1 furthermore represents together with R3 or R5 -(CH2)3-, -(CH2)4-, -(CH2)5-, R3 and R4 furthermore together represent -(CH2)4-, -(CH2)5-, -(CH2)6-, R3 and R5 furthermore together represent -(CH2)2-, -(CH2)3-, -(CH2)4-, R5 and R6 furthermore together represent -(CH2)4-, -(CH2)5-, -(CH2)6-. Amino alcohols of the formula (II) are widely known and/or can be prepared according to known methods. The formula (IV) provides a general definition of the mercaptans or salts thereof required as starting materials for carrying out the second step of the process according to the invention. Preferred as starting material are mercaptans or salts thereof of the formula (IV), in which R represents unsubstituted or mono- or polysubstituted C1-C12--alkyl, where the substituents are identical or different and are selected from the group consisting of fluorine, chlorine, bromine, iodine, hydroxy, C1-C4-alkoxy, halo-C1-C4-alkoxy having 1 to 9 identical or different fluorine, chlorine and/or bromine atoms, C1-C4-alkylthio, C1-C4-alkylsulfinyl and C1-C4-alkylsulfonyl; unsubstituted or mono- or polysubstituted C3-C6-cycloalkyl or C3-C6-cycloalkyl-C1-C2-alkyl, where the substituents are identical or different and are selected from the group consisting of fluorine, chlorine, bromine, iodine, C1-C4-alkyl and C1-C4-alkoxy, unsubstituted or mono- to pentasubstituted phenyl, where the substituents are identical or different and are selected from the group consisting of fluorine, chlorine, bromine, iodine, C1-C4-alkyl, C3-C6-cycloalkyl, C1-C4-alkoxy, halo-C1-C4-alkyl, halo-C1-C4-alkoxy, each having 1 to 9 identical or different fluorine, chlorine and/or bromine atoms; unsubstituted or mono- to pentasubstituted phenyl-C1-C2-alkyl, where the substituents are identical or different and are selected from the group consisting of fluorine, chlorine, bromine, iodine and C1-C4-alkyl; naphthyl; unsubstituted or mono-or polysubstituted heteroaryl (preferably furyl, thienyl, pyrrolyl, oxazolyl, oxazolinyl, isoxazolyl, thiazolyl, isothiazolyl, imidazolyl, pyrazolyl, 1,2,4-oxadiazolyL 1,3,4-oxadiazolyl, 1,2,4-thiadiazolyl, 1,3,4-thiadiazolyl, 1,2,3-thiadiazolyl, 1,2,5-thiadiazolyl, 1,2,3-triazolyl, 1,2,4-triazoryl, tetrazolyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, triazinyl), where the substituents are identical or different and are selected from the group consisting of fluorine, chlorine, bromine, iodine, C1-C4-alkyl, C1-C4-alkoxy, unsubstituted or mono- to pentasubstituted phenyl, where the substituents are identical or different and are selected from the group consisting of fluorine, chlorine, bromine, iodine and C1-C4-alkyl, M represents hydrogen, ammonium or an alkali metal atom (preferably sodium, potassium, lithium and caesium). Particularly preferred as starting material are mercaptans or salts thereof of the formula (IV), in which R represents in each case unsubstituted or mono- or polysubstituted methyl, ethyl, n-, i-propyl, n-, i-, s-, t-butyl, in each case the isomeric pentyls, hexyl, octyl, decyls and dodecyls, where the substituents are identical or different and are selected from the group consisting of fluorine, chlorine, bromine, iodine, hydroxy, methoxy, ethoxy, n-, i-propoxy, n-, i-, s-, t-butoxy, trifluoro-methoxy, trichloromethoxy, difluoromethoxy, dichloromethoxy, difluoro-chloromethoxy, fluorodichlorpmethoxy, methylthio, ethylthio, n-, i-propyl-thio, n-, i-, s-, t-butylthio, methylsulfinyl, ethylsulfinyl, n-, i-propylsulfinyl, n-, i-, s-, t-burylsulfinyl, methylsulfonyl, ethylsulfonyl, n-, i-propylsulfonyl, n-, i-, s-, t-butylsulfonyl; in each case unsubstituted or mono- or polysubstituted cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyL cyclobutylmethyl, cyclopentylmethyl, cyclohexylmethyl, cyclopropylethyl, cyclobutylethyl, cyclopentylethyl, cyclohexylethyl, where the substituents are identical or different and are selected from the group consisting of fluorine, chlorine, bromine, iodine, methyl, ethyl, n-, i-propyl, n-, i-, s-, t-butyl, methoxy, ethoxy, n-, i-propoxy, n-, i-, s-, t-butoxy; unsubstituted or mono- to trisubstituted phenyl, where the substituents are identical or different and are selected from the group consisting of fluorine, chlorine, bromine, iodine, methyl, ethyl, n-, i-propyl, n-, i-, s-, t-butyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, methoxy, ethoxy, n-, i-propoxy, n-, i-, s-, t-butoxy, tri-fluoromethyl, trichloromethyl, difluoromethyl, dichloromethyl, difluoro- chloromethyl, fluorodichloromethyl, trifluoromethoxy, trichoromethoxy, difluoromethoxy, dichloromethoxy, difluorochloromethoxy, fluorodichloro-methoxy, in each case unsubstituted or mono- to trisubstiruted benzyl or phenylethyl, where in each case the substituents are identical or different and are selected from the group consisting of fluorine, chlorine, bromine, iodine and methyl, ethyl, n-, i-propyl, n-, i-, s-, t-butyl; naphthyl; in each case unsubstituted or mono- or polysubstituted furyl, thienyl, pyrrolyl, oxazolyl, oxazolinyl, isoxazolyl, thiazolyl isothiazolyl, imidazolyl, pyrazolyl 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,4-thiadiazolyl, 1,3,4-thiadiazolyl, 1,2,3-thiadiazolyL 1,2,5-thiadiazolyl 1,2,3-triazolyl, 1,2,4-triazolyl, tetrazolyL pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, triazinyl, where in each case the substituents are identical or different and are selected from the group consisting of fluorine, chlorine, bromine, iodine, methyl, ethyl, n-, i-propyl, n-, i-, s-, t-butyl, methoxy, ethoxy, n-, i-propoxy, n-, i-, s-, t-butoxy, unsubstituted or mono- to trisubstituted phenyl, where the substituents are identical or different and are selected from the group consisting of fluorine, chlorine, bromine, iodine and methyl, ethyl, n-, i-propyl, n-, i-, s-, t-butyl, M represents hydrogen, ammonium, sodium, potassium, lithium and caesium. Very particularly preferred as starting material are mercaptans or salts thereof of the formula (IV), in which R represents in each case unsubstituted or mono- or polysubstituted methyl, ethyl, n-, i-propyl, n-, i-, s-, t-butyl, in each case the isomeric pentyls, hexyl, octyl, decyls and dodecyls, where the substituents are identical or different and are selected from the group consisting of fluorine, chlorine, bromine, iodine, hydroxy, methoxy, ethoxy, n-, i-propoxy, n-, i-, s-, t-butoxy, trifluoro-methoxy, trichloromethoxy, methylthio, ethylthio, n-, i-propylthio, t-butylthio, methylsulfrnyl, ethylsulfinyl, n-, i-propylsulfrnyL t-butylsulfinyl, methylsulfo-nyl, ethylsulfonyl, n-, i-propylsulfonyl, t-butylsulfonyl; in each case unsubstituted or mono- or polysubstituted cyclopropyl, cyclopentyl, cyclohexyl, cyclo- propylmethyl, cyclopentyfmethyl, cyclohexylmethyl, where the substituents are identical or different and are selected from the group consisting of fluorine, chlorine, bromine, iodine, methyl, ethyl, n-, i-propyl, t-butyl, methoxy, ethoxy, n-, i-propoxy, t-butoxy; unsubstituted or mono- to trisubstituted phenyl, where the substituents are identical or different and are selected from the group consisting of fluorine, chlorine, bromine, iodine, methyl, ethyl, n-, i-propyL n-, i-, s-, t-butyl, cyclopropyl, cyclopentyl, cyclohexyl, methoxy, ethoxy, n-, i-propoxy, n-, i-, s-, t-butoxy, trifiuoromethyl, difiuoromethyl, trifluoromethoxy, unsubstituted or mono- to trisubstituted benzyl, where the substituents are identical or different and are selected from the group consisting of fluorine, chlorine, bromine, iodine and methyL ethyl, n-, i-propyl, n-, i-, s-, t-butyl; naphthyl; in each case unsubstituted or mono- or polysubstituted furyl, thienyl, pyrrolyl, oxazolyl, oxazolinyl, isoxazolyl, thiazolyl, isothiazo-lyl, imidazolyl, pyrazolyl, 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,4-thiadi-azolyl, 1,3,4-thiadiazolyl, 1,2,3-thiadiazolyl, 1,2,5-thiadiazolyl, 1,2,3-triazo-lyl, 1,2,4-triazolyL tetrazolyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, triazinyl, where in each case the substituents are identical or different and are selected from the group consisting of fluorine, chlorine, bromine, methyl, ethyl, n-, i-propyl, n-, i-, s-, t-butyl, methoxy, ethoxy, n-, i-propoxy, n-, i-, s-, t-butoxy, unsubstituted or mono- to trisubstituted phenyl, where the substituents are identical or different and are selected from the group consisting of fluorine, chlorine, bromine and methyl, ethyl, n-, i-propyl, n-, i-, s-, t-butyl, M represents hydrogen, ammonium, sodium and potassium. Mercaptans or salts thereof of the formula (IV) are widely known and/or can be prepared according to known methods. Saturated or unsaturated hydrocarbon radicals, e.g. alkyl and alkenyl, can in each case be straight-chain or branched as far as this is possible, including in combination with heteroatoms, e.g. in alkoxy. Optionally substituted radicals may be mono- or polysubstituted, where in the case of polysubstitution the substituents may be identical or different Radicals subsituted by halogen, e.g. haloalkyl, are mono- or polysubsituted up to perhalogenation. In the case of multiple halogenation the halogen atoms may be identical or different. Halogen represents fluorine, chlorine, bromine or iodine. However, it is also possible to combine the above-mentioned general or preferred radical definitions or illustrations with one another as desired, i.e. between the respective ranges and preferred ranges. The definitions apply both to the end products and, correspondingly, to the precursors and intermediates. The first step of the reaction according to the invention can be carried out by addition of the amino alcohols of the formula (II) into the oleum. This procedure is preferably carried out with mechanical stirring in that way, that the added amino alcohol does not touch the glass surface of the reaction vessel. The addition of the amino alcohol of the formula (II) into the oleum is preferably done with cooling to keep the temperature below 150°C, while a temperature range between 80°C and 90°C is particularly preferred. In general a carbonization will not be observed even if higher substituted amino alcohols are employed. The amino alcohols are applied in liquid form. Solutions with up to 15 % water may also be used. According to the invention oleum means a solution of sulphur trioxide (SO3) in sulphuric acid. The content of SO3 can be varied in a broad range. In general between 1 % and 70 % SO3 are used. Preferably the reaction is carried out using between 15 % and 60 %, particularly preferably 15 % and 30 %, very particularly preferably 20 % SO3. For example, 40 % oleum means that 100 g of this solution contains 40 g ofSO3. The reaction temperatures employed to the first step of the reaction according to the invention may be varied over a broad range. In general the reaction is carried out between 50°C and 200°C, preferably between 70°C and 180°C, particularly preferably between 80°C and 130°C. The first step of the reaction is expediently carried out under atmospheric pressure, although it is also possible to work under reduced or elevated pressure. Particular preference is given to carrying out the reaction under atmospheric pressure. The reaction time can be different depending on the scale of the reaction and may vary between 10 min and 4 hours. The first step of the process is carried out in practice by reacting, for example, 1 mol of an amino alcohol of formula (II) with between 0.01 and 6 mol, preferably between 0.05 and 3 mol, particularly preferably between 0.1 and 1 mol, very particularly between 0.2 and 0.8 mol, especially preferably 0.6 mol of SO3, which is applied as solution in sulphuric acid (i.e. oleum, see above). The sulphuric acid esters of the formula (III) may be isolated. Preferably these esters of formula (III) are used without isolation for the conversion in the second step of the process according to the invention. The second step of the reaction according to the invention can be carried out by addition of the mercaptans or salts thereof of formula (IV), if as salt, then preferably in form of an aqueous solution of said mercaptan salt, into of the sulphuric acid ester of formula (III). Before this addition the reaction mixture is diluted with water and neutralized with a base. The reaction mixture may be neutralized directly when the reaction is carried out in small scale, for example in laboratory scale. The addition of the mercaptans or salts thereof of formula (IV) is done between 10 min up to 24 h, depending on the scale of the reaction, preferably between 20 min and 12 h, particularly preferably between 30 min and 6 h. The second step of the process is carried out in the presence of a base. Examples which may be mentioned are: alkali metal and alkaline earth metal hydroxides, such as NaOH, KOH, Ca(OH)2, alkali metal carbonates or hydrogencarbonates, such as Na2CO3, Li2CO3, K2CO3, Cs2CO3 or NaHCO3 and KHCO3. Preference is given to Na2CO3, KOH, NaOH and NaHCO3, in particular NaOH. The reaction temperatures employed to the second step of the reaction according to the invention may be varied over a broad range. In general the reaction is carried out between 30°C and 150°C, preferably between 50°C and 120°C, particularly preferably between 60°C and 80°C. The second step of the reaction is expediently carried out under atmospheric pressure, although it is also possible to work under reduced or elevated pressure. Particular preference is given to carrying out the reaction under atmospheric pressure. The second step of the reaction according to the invention may be carried out in the presence of a further diluent, where all customary inert organic solvents apply. Preference is given to using optionally halogenated aliphatic, alicyclic or aromatic hydrocarbons, such as petroleum ether, hexane, heptane, cyclohexane, methyl-cyclohexane, benzene, toluene, xylene or decaline; chlorobenzene, dichlorobenzene, dichloromethane, chloroform, tetrachloromethane, dichlorethane or trichloroethane; ethers, such as diethyl ether, diisopropyl ether, methyl tert.-butyl ether, methyl tert-amyl ether, dioxane, tetrahydrofuran, 1,2-dimethoxyethane, 1,2-diethoxyethane or anisole; nitriles, such as acetonitrile, propionitrile, n- or isobutyronirrile or benzo-nitrile; amides, such as N,N-dimethylformarnide, N,N-dimethylacetamide, N-methyl-formanilide, N-methylpyrrolidone or hexamethylphosphoric triamide; esters, such as methyl acetate or ethyl acetate, sulphoxides, such as dimethyl sulphoxide, or sulphones, such as sulpholane. The second step of the process is carried out in practice by reacting, for example, 1 mol of an sulphuric acid ester of formula (III) with between 1 and 10 mol, preferably between 1 and 5 mol, particularly preferably between 1 and 3 mol of an mercaptan or salt thereof of formula (IV) in the presence of a base, to keep the pH value in general between pH 11 and 12. The end-product can be isolated using standard procedures, e.g. cristallization, chromatography, extraction and distillation. The process according to the invention is illustrated by the preparation examples given below. Preparation Examples Example 1 (Formula Removed) The oleum (120.1 g of 20 % SO3 in H2SO4, i.e. 0.3 mol = 0.6 eq. SO3) is placed in an 11 flat-bottomed flask with flat-flange joint and the 2-amino-2-methyl-l-propanol (46.9 g, 0.5 mol = 1 eq., 95 %) is added slowly with mechanical stirring directly into the oleum so that 2-amino-2-methyl-l-propanol touches the glass surface of the flask. The temperature is maintained by cooling between 85°C and 90°C. Stirring of the reaction mixture at 90°C is continued for additional 30 min. After cooling to room temperature the mixture is first diluted with 200 ml of water and then 45 % sodium hydroxide solution in water is added. The temperature in both procedures should not exceed 30°C. Under cooling the methyl mercaptane sodium salt solution (183.6 g, 0.5 mol = 1 eq., 19.1 % in water) is added and then stirring is continued at 60 to 65°C for 6h. The mixture is cooled to 32°C and all the following procedures are performed at this temperature. 100 ml methyl tert-butyl ether is added, the mixture is stirred and the organic layer is separated. The aqueous layer is extracted with two 100 ml portions of tert.-butyl ether. The combined organic layers were dried over anhydrous sodium sulfate. After filtration the solvent was removed at 20°C and under 150 mbar reduced pressure. Yield: 62.7 g (crude product, purity according to internal standard: 68.8 %, i.e. 72 % of the theory) of 2-methyl-l-methylthio-2-propanamine. 1H NMR(d6-DMSO): δ= 1.04 (s, 6H), 1.44 (broad, 2H), 2.10 (s, 3H), 2.48 (s, 2H) ppm. GC/MS-coupling: m/z (%) = 104 (3) [M-15]+, 58 (100), 42 (11), 41 (8), 31 (5). Example 2 (Formula Removed) The oleum (91.4 g of 20 % SO3 in H2SO4, i.e. 0.23 mol = 0.7 eq. SO3) is placed in an 11 flat-bottomed flask with flat-flange joint and the 2-aminopropanol (25.0 g, 0.33 mol = 1 eq.) is added slowly with mechanical stirring directly into the oleum. The temperature is maintained by cooling slightly below 80°C. Stirring of the reaction mixture without heating is continued for additional 30 min. After cooling to room temperature the mixture is first diluted with 70 ml of water and then slowly 45 % sodium hydroxide solution in water is added until a pH value of 11 is reached. The temperature in both procedures should not exceed 30°C. Under cooling the methyl mercaptane sodium salt solution (82.2 g, 0.33 mol = 1 eq., 19.1 % in water) is added and then stirring is continued at 60°C for 12 h. The mixture is cooled to 32°C and all following procedures are performed at this temperature. 75 ml methyl tert.-butyl ether is added, the mixture is stirred and the organic layer is separated. The aqueous layer is extracted with two 75 ml portions of methyl tert.-butyl ether. The combined organic layers were dried over anhydrous sodium sulfate. After filtration the solvent was removed at 20°C and under 150 mbar reduced pressure. Yield: 23.3 g (62.2 %, crude product, yield according to GC-purity) of 1-methylthio- 2-propanamine. 1H NMR (d6-DMSO): δ = 1.01 (d, 3H), 1.48 (broad, 2H), 2.04 (s, 3H), 2.38 (m, 2H), 2.90(m,lH)ppm. GCMS-coupling: m/z (%) = 105 (4) [M]+, 61 (5), 44 (100), 42 (12), 41 (5), 28 (4). Example 3 (Formula Removed) The oleum (45.4 g of 20 % SO3 in H2SO4, i.e. 0.114 mol = 0.7 eq. SO3) is placed in an 11 flat-bottomed flask with flat-flange joint and the 3-(isopropylamino)-l-propan-ol (19.0 g, 0.16 mol= 1 eq.) is added slowly with mechanical stirring directly into the oleum. The temperature is maintained by cooling slightly below 80°C. Stirring is continued for additional 60 rnin. After cooling to room temperature the mixture is first diluted under cooling with 70 ml of water and then slowly 45 % sodium hydroxide solution in water is added until a pH value of 11 is reached. The temperature in both procedures should not exceed 30°C. Under cooling the methyl mercaptane sodium salt solution (59.5 g, 0.16 mol = 1 eq., 19.1 % in water) is added and then stirring is continued at 60°C for 12 h. The mixture is cooled to 32°C and all following procedures are performed at this temperature. 75 ml methyl tert.-butyl ether is added, the mixture is stirred and the organic layer is separated. The aqueous layer is extracted with two 75 ml portions of methyl teit-butyl ether. The combined organic layers were dried over anhydrous sodium sulfate. After filtration the solvent was removed at 20°C and under 150 mbar reduced pressure. Yield: 12.6 g (48.5 %, crude product, yield according to GC-purity) of N-isopropyl- 3 -methylthio-1 -prop anamine. 1HNMR(d5-DMSO): δ = 0.95 (d, 6H), 1.63 (m, 2H), 2.03 (s, 3H), 2.52 (m, 4H), 2.66 (m, 1H) ppm. GC/MS-coupling: m/z (%) = 147 (17) [M]+, 132 (36), 89 (48), 72 (100), 58 (40), 30 (60). Example 4 (Formula Removed) The oleum (28.4 g of 20 % SO3 in H2SO4, i.e. 0.07 mol = 0.7 eq. SO3) is placed in an 11 flat-bottomed flask with flat-flange joint and the 2-amino-2-metiiylpropanol (9.4 g, 0.10 mol = 1 eq.) is added slowly with mechanical stirring directly into the oleum. The temperature is maintained by cooling slightly below 80°C. Stirring without heating is continued for additional 30 min. After cooling to room temperature the mixture is first diluted with 30 ml of water and then slowly 45 % sodium hydroxide solution in .water is added until a pH value of 11 is reached. The temperature in both procedures should not exceed 30°C. Under cooling the 4-methyl thiophenol (12.4 g, 0.1 mol = 1 eq.) is added and then stirring is continued at 60°C for 12 h. The mixture is diluted with 100 ml water, then 100 ml ethylacetate is added, the mixture is stirred and the organic layer is separated. The organic layer is washed twice with 50 ml portions of water. The organic layer is dried over anhydrous sodium sulfate. After filtration the solvent is removed at 20°C and under 150 mbar reduced pressure. Yield: 15.4 g (57.3 % crude product, yield according to GC-purity of 72.6 %) of 2-methyl-1 -[(4-methylphenyl)thio]-2-propanamine. GC/MS-coupling: m/z (%) = 195 (1) [M]+, 138 (16), 58 (100). Example 5 (Formula Removed) Applying the procedure according to example 4 the compound l-(l,3-benzothiazol-2-ylt3no)-2-methyl-2-propananrine is obtained. Yield: 37.9 % (according to GC-purity of 37.8 %). GC/MS-coupling: m/z (%) = 238 (2) [M]+, 181 (6), 148 (5), 108 (4), 58 (100), 28 (9). Example 6 (Formula Removed) Applying the procedure according to example 4 the compound 2-[(2-arnino-2-methylpropyl)tbio]ethanol is obtained. Yield: 24.8 % (according to GC-purity of 74.0 %). GC/MS-coupling: m/z (%) = 134 (2) [M-15]+, 88 (3), 58 (100), 42 (7). Example 7 (Formula Removed) Applying the procedure according to example 4 the compound 3-[(2~amino-2-methylpropyl)thio]-l-propanol is obtained. Yield: 57.9 % (according to GC-purity of 71.6 %). GC/MS-coupling: m/z (%) = 163 (1) {M]+, 148 (1) [M+ - 15], 58 (100), 42 (6). Example 8 (Formula Removed) Applying the procedure according to example 4 the compound 6-[(2-arnino-2-methylpropyl)thio]-l-hexanol is obtained. Yield: 40.7 % (according to GC-purity of 61.9 %). GC/MS-coupling: m/z (%) = 205 (1) [M]+, 190 (2) [M-15]+, 58 (100), 41 (7). We Claim: 1. A process for the preparation of thioalkylamine derivatives of formula (I): (Formula Removed) in which R1 and R2 independently of one another represent hydrogen, C1-C4-alkyl, C3-C8-cycloakyl, C3-C8-cycloalkyl-C1-C4-alkyl, or hydroxy-C1-C4-alkyl; represent unsubstituted or mono-to pentasubstituted phenyl, where the substituents are identical or different and are selected from the group consisting of halogen, cyano, nitro, C1-C4-alkyl, C3-C8-cycloalkyl, C1-C4-alkoxy, C1-C4-alkylthio, C1-C4-alkylsulfinyl, C1-C4-alkylsulfonyl, carboxyl, C1-C4-alkoxycarbonyl, C1-C4-alkoxy-C1-C4-alkyl, C1-C4-alkylcarbonyl, halo-C1-C4-alkyl, halo-C1-C4-alkoxy, halo-C1-C4-alkylthio, halo-C1-C4-alkyl-sulfinyl, halo-C1-C4-alkyl-sulfonyl, halo-C1-C4-alkylcarbonyl, phenylcarbonyl, phenoxy-carbonyl, amino, C1-C4-alkyl-amino, and di(C1-C4-alkyl)amino in which the alkyl groups can be identical or different; represent phenyl that is substituted at two adjacent carbon atoms by C3-C4-alkylene or C1-C2-alkylenedioxy; or represent unsubstituted or mono- to pentasubstituted phenyl-C1-C4-alkyl, where the substituents are identical or different and are selected from the group consisting of halogen, cyano, nitro, C1-C4-alkyl, C3-C8-cycloalkyl, C1-C4-alkoxy, C1-C4-alkylthio, C1-C4-alkylsulfinyl, C1-C4-alkylsulfonyl, halo-C1-C4-alkyl, halo-C1-C4-alkoxy, halo-C1-C4-alkylthio, halo-C1-C4-alkylsulfinyl, and halo-C1-C4-alkylsulfonyl; R3 and R4 independently of one another represent hydrogen or C1-C4-alkyl, R5 and R6 independently of one another represent hydrogen or C1-C4-alkyl; represent unsubstituted or mono- to pentasubstituted phenyl, where the substituents are identical or different and are selected from the group consisting of halogen, cyano, nitro, C1-C4-alkyl, C3-C8-cycloalkyl, C1-C4-alkoxy, C1-C4-alkylthio, C1-C4-alkylsulfinyl, C1-C4-alkylsulfonyl, halo-C1-C4-alkyl, halo-C1-C4-alkoxy, halo-C1-C4-alkylthio, halo- C1-C4-alkylsulfinyl, and halo-C1-C4-alkylsulfonyl; or represent unsubstituted or mono- to pentasubstituted phenyl-C1-C4-alkyl, where the substituents are identical or different and are selected from the group consisting of halogen, cyano, nitro, C1-C4-alkyl, C3-C8-cycloalkyl, C1-C4-alkoxy, C1-C4-alkylthio, C1-C4-alkylsulfinyl, C1-C4-alkylsulfonyl, halo- C1-C4-alkyl, halo- C1-C4-alkoxy, halo-C1-C4-alkylthio, halo- C1-C4-alkylsulfinyl, and halo-C1-C4-alkylsulfonyl, R represents unsubstituted or mono- or polysubstituted C1-C12-alkyl, where the substituents are identical or different and are selected from the group consisting of halogen, hydroxy, C1-C4-alkoxy, halo-C1-C4-alkoxy, C1-C4-alkylthio, C1-C4-alkylsulfinyl, and C1-C4-alkylsulfonyl; represents unsubstituted or mono- or polysubstituted C3-C8-cycloalkyl or C3-C8-cycloalkyl- C1-C4-alkyl, where the substituents are identical or different and are selected from the group consisting of halogen, C1-C4-alkyl, and C1-C4-alkoxy; represents unsubstituted or mono- to pentasubstituted phenyl, where the substituents are identical or different and are selected from the group consisting of halogen, C1-C6-alkyl, C3-C8-cycloalkyl, C1-C4-alkoxy, halo-C1-C4-alkyl, and halo-C1-C4-alkoxy; represents unsubstituted or mono to pentasubstituted phenyl- C1-C4-alkyl, where the substituents are identical or different and are selected from the group consisting of halogen and C1-C4-alkyl; represents naphthyl; or represents unsubstituted or mono or polysubstituted heteroaryl, where the substituents are identical or different and are selected from the group consisting of halogen, C1-C4-alkyl, C1-C4-alkoxy, and unsubstituted or mono- to pentasubstituted phenyl in which the substituents are identical or different and are selected from the group consisting of halogen and C1-C4-alkyl, and n represents 1, 2, 3, 4, 5, 6, 7, or 8, with the proviso that the group C(R1)R2 may be identical or different when n is greater than 1, with the further proviso that when n represents 1, R1 and R2 optionally together represent C3-C5-alkylene, R1 together with R3 or R5 optionally represent C3-C5-alkylene, R3 and R4 optionally together represent C4-C6-alkylene, R3 and R5 optionally together represent C2-C4-alkylene, and R5 and R6 optionally together represent C4-C6-alkylene, comprising (1) reacting in a first step an amino alcohol of formula (II) (Formula Removed) in which R1, R2, R3, R4, R5, R6 and n have the meanings given for formula (I), and with oleum to give a sulphuric acid ester of formula (III): (Formula Removed) in which R1, R2, R3, R4, R5, R6 and n have the meanings given for formula (I) and (2) reacting in a second step the resultant sulphuric acid ester with a mercaptan of formula (IV) RSM (IV) Or a salt thereof In which R has the meanings given for formula (I), and M represents hydrogen, ammonium, or an alkali metal atom, in the presence of a base and optionally in the presence of a diluent, wherein the reaction mixture is diluted with water and neutralized with a base before the sulfuric acid esters of the first step are reacted in the second step. 2. Process as claimed in claim 1, wherein a compound of the formula (II), in which R1 and R2 in each case independently of one another represent hydrogen, C1-C4-aikyl, C3-C6-cycloalkyl, C3-C6-cycloalkyl-C1-C2-alkyl, hydroxy-C1-C4-alkyl; unsubstituted or mono- to pentasubstituted phenyl, where the substituents are identical or different and are selected from the group consisting of fluorine, chlorine, bromine, iodine, cyano, nitro, C1-C4-alkyl, C3-C6-cycloalkyl, C1-C4-alkoxy, C1-C4-alkylthio, C1-C4-alkyl-sulfinyl, C1-C4-alkylsulfonyl, carboxyl, C1-C4-alkoxycarbonyl, C1-C4-alkoxy-C1-C4-alkyl, C1-C4-alkylcarbonyl, halo-C1-C4-alkyl, halo-C1-C4-alkoxy, halo-C1-C4-alkylthio, halo-C1-C4-alkylsulfinyl, halo-C1-C4-alkylsulfonyl, halo-C1-C4-alkylcarbonyl, each having 1 to 9 identical or different fluorine, chlorine and/or bromine atoms, phenylcarbonyl, phenoxycarbonyl, amino, C1-C4-alkylamino and di-(Ct-C4-alkyl)-amino (where the alkyl groups can be identical or different); phenyl, which is substituted at two adjacent carbon atoms by C3-C4-alkylene or C1-C2-alkylenedioxy; unsubstituted or mono- to pentasubstituted phenyl-C1-C2-alkyl, where the substituents are identical or different and are selected from the group consisting of fluorine, chlorine, bromine, iodine, cyano, nitro, C1-C4-alkyl, C3-C6-cycloalkyl, C1-C4-alkoxy, C1-C4-alkylthio, C1-C4-alkylsulfinyl, C1-C4-alfcylsulfohyl, halo-C1-C4-alkyl, halo-C1-C4-alkoxy, halo-C1-C4-alkylthio, halo-C1-C4-alkylsulfinyl and halo-C1-C4-alkylsulfonyl, each having 1 to 9 identical or different fluorine, chlorine and/or bromine atoms; R3 and R4 independently of one another represent hydrogen or C1-C4-alkyl, R5 and R6 independently of one another represent hydrogen, C1-C4-alkyl, unsubstituted or mono- to pentasubstituted phenyl, where the substitu-ents are identical or different and are selected from the group consisting of fluorine, chlorine, bromine, iodine, cyano, nitro, C1-C4-alkyl, C3-C6-cycloalkyl, C1-C4-alkoxy, C1-C4-alkylthio, C1-C4-alkylsulfinyl, C1-C4-alkylsulfonyl, halo-C1-C4-alkyl, halo-C1-C4-alkoxy, halo-C1-C4-alkylthio, halo-C1-C4-alkylsulfinyl and halo-C1-C4-alkylsulfonyl, each having 1 to 9 identical or different fluorine, chloorine and/or bromine atoms; unsubstituted or mono- to pentasubstituted phenyl-C1-C2-alkyl, where the substituents are identical or different and are selected from the group consisting of fluorine, chlorine, bromine, iodine, cyano, nitro, C1-C4-alkyl, C3-C8-cycloalkyl,C1-C4-alkoxy, C1-C4-alkylthio, C1-C4-alkylsulfinyl, C1-C4-alkylsulfonyl, halo-C1-C4-alkyl, halo-C1-C4-alkoxy, halo-C1-C4-alkylthio, halo-C1-C4-alkylsnlfinyl and halo-C1-C4-alkylsubfonyl, each having 1 to 9 identical or different fluorine, chlorine and/or bromine atoms; n represents 1,2,3,4, 5 or 6, where the group C(R1)R2 may be identical or different, when h is greater than 1, and when n represents 1, R1 and R2 furthermore together represent C2-C5-alkylene, R1 furthermore represents together with R3 or R5 C3-C5-alkylene, R3 and R4 furthermore together represent C4-C6-alkylene, R3 and R5 furthermore together represent C2-C4-alkylene, R5 ahd R6 forthennore together represent C4-C6-alkylene, is used. 3. Process as claimed in either claim 1 or claim 2, wherein a compound of the formula (IV), in which R represents unsubstituted or mono- or polysubstituted C1-C12-alkyl, where the substituents are identical or different and are selected from the group consisting of fluorine, chlorine, bromine, iodine, hydroxy, C1-C4-alkoxy, halo-C1-C4-alkoxy having 1 to 9 identical or different fluorine, chlorine and/or bromine atoms, C1-C4-alkylthio, C1-C4-alkyl-sulfinyl and C1-C4-alkylsulfonyl; unsubstituted or mono- or polysubstituted C3-C6-cycloalkyl or C3-C6-cycloalkyl-C1-C2-alkyl, where the substituents are identical or different and are selected from the group consisting of fluorine, chlorine, bromine, iodine, C1-C4-alkyl and C1-C4-alkoxy; unsubstituted or mono- to pentasubstituted phenyl, where the substituents are identical or different and are selected from the group consisting of fluorine, chlorine, bromine, iodine, C1-C4-alkyl, C3-C6-cycloalkyl, C1-C4-alkoxy, halo-C1-C4-alkyl, halo-C1-C4-alkoxy, each having 1 to 9 identical or different fluorine, chlorine and/or bromine atoms; unsubstituted or mono- to pentasubstituted phenyl-C1-C2-alkyl, where the substituents are identical or different and are se-lected from the group consisting of fluorine, chlorine, bromine, iodine and C1-C4-alkyl; naphthyl; unsubstituted or mono- or polysubstituted heteroaryl (preferably furyl, thienyl, pyrrolyl, oxazolyl, oxazolinyl, isoxazolyl, thiazolyl, isothiazolyl, imidazolyl, pyrazolyl, 1,2,4-oxadi-azolyl, 1,3,4-oxadiazolyl, 1,2,4-thiadiazolyl, 1,3,4-thiadiazolyl, 1,2,3-thiadiazolyl, 1,2,5-thiadiazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, tetrazo-lyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, triazinyl), where the substituents are identical or different and are selected from the group consisting of fluorine, chlorine, bromine, iodine, C1-C4-alkyl, C1-C4-alkoxy, unsubstituted or mono- to pentasubstituted phenyl, where the substituents are identical or different and are selected from the group consisting of fluorine, chlorine, bromine, iodine and C1-C4-alkyl, M represents hydrogen, ammonium or an alkali metal atom (preferably sodium, potassium, lithium and caesium), is used. 4. Process as claimed in any one of claims 1 to 3, wherein the oleum contains between 1% and 70% SO3. 5. Process as claimed in any one of claims 1 to 4, wherein the first step of the reaction is carried out at a temperature of between 50°C and 200°C. 6. Process as claimed in any one of claims 1 to 5, wherein within the first step per mol amino alcohol of formula (II) between 0.01 and 6 mol of SO3, which is applied as solution in sulphuric acid (i.e. oleum) are used. 7. Process as claimed in any one of claims 1 to 6, wherein the sulphuric acid esters of formula (III) are used without isolation. 8. Process as claimed in any one of claims 1 to 7, wherein the base employed in the second step of the process is selected from the group consisting of alkali metal and alkaline earth metal hydroxides, alkali metal carbonates or hydrogencarbonates.

Documents:

3595-DELNP-2004-Abstract-(15-07-2011).pdf

3595-DELNP-2004-Abstract-(20-01-2011).pdf

3595-delnp-2004-abstract.pdf

3595-DELNP-2004-Claims-(15-07-2011).pdf

3595-DELNP-2004-Claims-(20-01-2011).pdf

3595-delnp-2004-claims.pdf

3595-DELNP-2004-Correspondence Others-(08-09-2011).pdf

3595-DELNP-2004-Correspondence Others-(14-03-2012).pdf

3595-DELNP-2004-Correspondence Others-(15-07-2011).pdf

3595-delnp-2004-Correspondence-Others-(01-10-2012).pdf

3595-DELNP-2004-Correspondence-Others-(20-01-2011).pdf

3595-delnp-2004-correspondence-others.pdf

3595-DELNP-2004-Description (Complete)-(20-01-2011).pdf

3595-delnp-2004-description (complete).pdf

3595-delnp-2004-form-1.pdf

3595-delnp-2004-form-18.pdf

3595-delnp-2004-form-2.pdf

3595-DELNP-2004-Form-3-(14-03-2012).pdf

3595-DELNP-2004-Form-3-(20-01-2011).pdf

3595-delnp-2004-form-3.pdf

3595-delnp-2004-form-5.pdf

3595-DELNP-2004-GPA-(20-01-2011).pdf

3595-delnp-2004-gpa.pdf

3595-delnp-2004-pct-101.pdf

3595-delnp-2004-pct-210.pdf

3595-delnp-2004-pct-304.pdf

3595-delnp-2004-pct-409.pdf

3595-DELNP-2004-Petition 137-(20-01-2011).pdf

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