Title of Invention

NOVEL BENZOXAZOCINES COMPOUNDS

Abstract

Compounds of the general formula (1), wherein one of W, X, Y and Z is N or CR4 and the others are each CH; and R4 is a specified substituent. These compounds inhibit monoamine reuptake, and are useful in the treatment of pain, emesis depression, post traumatic stress disorders, attention deficit disorders, obsessive compulsive disorders, pre-menstrual syndrome, substance abuse and sexual dysfunction.

Full Text

This invention relates to novel benzoxazoclne compounds which inhibit monoamine reuptake and their therapeutic use. Backoround of the Invention Nefopam f(± )-3.4.5.6-tetrahvdro-5-methvl-1 phenyl-1 H-2,5-benzQxazocine hydrochloride] is a centrally acting non-narcotic analgesic not structurally related to other analgesics. Nefopam has been shown to induce antinociception in animal models of pain and in humans (reviewed in Heel etal., 1980). However, nefopam is not active in the mouse tall-flick test, or the hot plate test and the Randall-Selitto pressure test in rats (Conway and Mitchell, 1977) suggesting that its analgesic meCHanism is not opiate-like or anti-inflammatory in nature. Nefopam's antinociception is not blocked by nalaxone further suggesting that its analgesic action is not through opiate receptors. Although the precise meCHanism of antinociception is not knovm it is thought to involve inhibition of synaptosomal uptake of dopamine, norepinephrine and serotonin (VonVoigtiander et a/., 1983; Rowland and Hole, 1990; Mather et ai, 2001). Previous in vitro and in vivo studies with nefopam enantiornere haveSbown that (+)-nefopam has more potent analgesic and dopamine, norepinephrine and serotonin uptake inhibitory properties than (-)-nefopam with the order of potency given as (+)-nefopam > (±)-nefopam > (-)-nefopam (Fasmeref a/., 1987; Rosland and Hole, 1990; Mather et al, 2001). summary of the Invention According to this invention, novel compounds are of general formula (1): (Formula Removed) wherein Ri is H. C1-C6alkyl, optionaily substituted with F or C3-C6 cyctoalky) or C2-C6 alkenyl; either R2 and R3 are the same or different and are H, a halogen. CN, CFa. C1-C6alkyI or OR1, or R2and R3 form a five or six membered ring which may be carbocyclic, heterocyclic (containing 1-2 heteroatoms taken from O, N or S), aromatic (such as in naphthalene for example), heteroaromatjc (containing 1-2 heteroatoms taken from O, such as In benzofuranfor example, N as in quinoiine, isoquinoline and quinazoiine for example); and W, X, Y or Z are each N, CH or CR4. The case where W = X = Y = Z = CH is specifically excluded. When W is N or R4, X = Y = Z = CH; when X is N or R4, W = Y = Z = CH; when Y is N or R4, W = X = Z = H; and when Z is N or R4, W = X = Y = CH. R4 is halogen, CFs, CN, OR7, SO2N(R6)2 (where each R6is the same or different), COR6, CO2R6, CON(R6)2 (where R6 maybe the same or different), NR1COR5, NR1SO6R6, NR1CO2R5, NR1CON(R6)2 (where each R6 is the same or different), OCi-Cs alkyl optionally substituted with R4, C1-C6 alkyl optionally substituted with R4, C3-C6cycloalkyl optionally substituted with R4, C2-C6 alkenyl optionally substituted with R4, C2-C6 aikynyl optionally substituted with R4, and aryl optionally substituted with R4. R4 may also be a five or six menrtbered aromatic heterocycle containing 1 -4 heteroatoms selected from N (such as in pyrrole, pyridine, diazoles, diazines, triazoles, triazines or tetrazoies for example) and O (such as In furan, oxazoles, isoxazoles or oxadlazoles for example). Such rings can be linked either through carbon or nitrogen. R5 is C1-C6alkyI, Cj-Csalkenyl, C2-C6 alkynyl, C3-C6cycloalkyI, aryl or heteroaryl. Re is H, C1-C6alkyl. C2-C6alkenyl. C2-C6 alkynyl, C3-C6cycloalkyI, aryl or heteroaryl. R7 is aryl or heteroaryl. Salts, solvates and polymorphs of these compounds are also included . Compounds of the invention are useful as therapeutic agents. Further, in compounds of formula (1), those wherein R4 is a halogen atom such as Br are useful as intermediates. Description of Preferred Embodiments It will be appreciated that the compourvSs according to the invention contain an asymmetricaUy si ihstitued carabon atom. The presence of this asymmetric centrejn compound of formula (1) can give rise to stereoisomers, and in each case the invention is to be understood to extend to atl such stereoisomers, including enantiomers and diastereomers, and mixtures including racemic and non-racemic mixtures thereof. As used in this specification, alone or in combination, the *erm "C1-C6 alkyl" refers to straight or branched CHain alkyl moiety having from one to six carbon atoms, Including for example, methyl, ethyl, propyl, isopropyl, butyl, tert-butyl, pentyl, hexyl and the like. The term "C2-C6 alkenyl" refers to a straight or branched CHain alkyl moiety having two to six carbon atoms and having in addition one double bond, of either E or Z stereochemistry where applicable. This term would include for example, vinyl, 1-propenyl, 1- and 2- butenyl, 2- methyl-2-propenyl etc. The term "C2-C6 alkynyl" refers to a straight or branched CHain alkyl moiety having two to six carbon atoms and having in addition one triple t>ond. This term would Include for example, ethynyl, 1 -propargyl, 1 - and 2- butynyl etc. The term "C3-C6 cycloalkyl" refers to a saturated alicydic moiety having from three to six carbon atoms and includes for example cyclopropyl, cyckjbutyl. cyclopentyl, cyclohexyl and the like. The term "aryl" means an optionally substituted phenyl or naphthyl group. The temn "carbocycllc" refers to a saturated alicyclic moiety having five or six carbon atoms and includes for example benzofused cyclopentyl and cyclohexyl and the like. The term "heterocyclic" refers to a saturated heterocyclic moiety having from five or six atoms but containing one or more heteroatom from the group N, O, S and Includes for example benzofused pyrrolidinyl, tetrahydrofuranyl, piperidinyl, dioxalane and the like. The term "heteroaromatic" refers to aromatic ring systems of five or six atoms or which at least one atom is selected from the group, O. N, or S and includes for example benzofused furanyl, thiophenyl, pyrtdyl, indolyl.pyridazinyl, piperazinyl, pyrimidinyl and the like. The term "halogen" means fluorine, chlorine, bromine or iodine. Compounds of the general formula (1) may be prepared by any suitable method known in the art and/or by the processes described below. It will be appreciated that where a particular stereoisomer of formula (1) is required, the synthetic processes described herein may be used with the appropriate homochiral starting material and/or isomers maybe resolved from mixtures using conventional separation techniques (e.g. HPLC). The compounds according to the invention may be prepared by the following process. In the description and formulae below the groups R1, R2, R3, R4, R5. R6, W, X, Y and Z are as defined above, except where otherwise indicated. It will be appreciated that functional groups, such as amino, hydroxy I or carboxyl groups, present in the various compounds described below, and which it is desired to retain, may need to be in protected form before any reaction is initiated. In such instances, removal of the protecting group may be the final step in a particular reaction. Suitable protecting groups for such functionality will be apparent to those skilied in the art. For specific details see "Protective Groups in Organic Synthesis", Wiley Interscience, TW Greene, PGM Wuts. A process required for preparing compounds of general formula (1), where W, X, Y or Z are N or C-Br comprises acid (for instance p-toluenesuiphonic acid) cyclisation of the diol of general formula (2) which can in turn be obtained by reduction of the ketone (3) with a suitable reducing agent. (Formula Removed) Reduction of a keto amide of general formula (3) can be carried out with reagents well known to those familiar in the art of synthetic organic chemistry. An example of a highly reactive reducing agent is lithium aluminium hydride, although reagents based on borane (e.g. borane.tetrahydrofuran complex) or modified sodium borohydride reduction (e.g. with a nickel or cobalt sait enhancer) are equally effective. Equally, reduction of the ketone in (3), for example with sodium borohydride, followed by acid cyclisation, for example with p-toluenesulphionic acid, then ultimate reduction of the amide group, for example with borane, aiso leads to compounds of general formula (1). Ketones of general formula (3) can be prepared by condensation of a carboxyiic acid of general formuia (4) or an active -derivative thereof, with an amine of formula (5). Active derivatives of acids of formula (4) include for example acid anhydrides or acid lialides, such as acid chlorides. (Formula Removed) The coupling reiction may be performed usirg standard conaitions for amidation reactions of this type. Thus, the reaction may be achieved In a solvent, for example an inert organic solvent such as an ether, e.g. acyclicether such as tetrahydrofuran, an amide e.g. a substituted amide such as dimethylformamide, or a halogenated hydrocarbon such as dichloromethane at a low temperature e.g. -30°C to ambient temperatuR6, such as -20°C to 0°C, optionally in the presence of as base. e.g. an organic base such as an amine, e.g. triethylamine or a cyclic amine such as .V-methy!morpholine. Where an acid of formula (4) is used directly, the reaction may additionally be performed in the presence of a condensing agent, for example a diimide such as N,N-dicyclohexylcarbodiimide, advantageously in the presence of a triazole such as 1-hydroxybenzotriazole. Alternatively, the acid may be reacted with a chioroformate, for example ethyl chloroformate, prior to reaction with the amine of formula (5). Acids of general formula (4) are prepared by Friedel-Crafts acyiation of an arene of general formula (6) with an anhydride of formula (7). This reaction is carried out in an Inert solvent (such as dichtoromethane) in the presence of a Lewis acid catalyst {such as aluminium trichloride). (Formula Removed) It is well recognised by those skilled in the art that such reactions may provide mixtures of products and in turn that these mixtures can often be separated by tradition flash column chromatography. For example, where Y = C-Br and W = X = Z = CH and Ra and Ra are H, Friedel-Crafts acylation under aluminium trichloride catalysis provides two isomeric bromides (4a) and (4b). These can be readily separated by column chromatography and IrKlependently progressed to compouna. of general formula (1), wherein X or Y are C-Br, by the route described above. (Formula Removed) Compounds of general formula (1) where either W, X, Y or Z is CR4 and R4 is a halogen such as Br (1a) represent flexible interniediates that may be used for the preparation of other compounds of general formula (1). For instance, compounds of general formula (1) where either W, X, YorZ is CR4and R4 Is Brcan be smoothly converted into the corresponding nitrile (1b; R4 - CN) either by react/on with cuprous cyanide in a dipolar aprotic solvent such as A/- methylpyrroiidinonG (NMP) or under palladium-catalysed conditions (Scheme 1). (SCHEME REMOVED) The nltrile of general formula (1) where either W, X, Y or Z is CR4 and R4 is CN (1b) can be readily converted, by hydrolysis, into the primary amide (1c, R4 = CONH2), esters and the corresponding carboxylic acid (Id, CO2R1) or into the corresponding tetrazole (1e) by treatment with a suitable azide donor such as sodium azide or trimethylsilylazide (SCHEME REMOVED) In addition, compounds of general formula (1) where either W, X, YorZ is CR4 and R4 is a halogen such as Br (1a) can be lithiated with n-, sec-, or tert-butyllithium in an inert organic solvent such as an ether, e.g. a cyclic ether such as tetrahydrofuran at very low temperatuR6, e.g. -78°C. Treatment with either a carbon (e.g. carbon dioxide, N,N-dimethyl formamide or paraformaldehyde), sulphur (e.g. SO2CI2, followed by amidation, such as with ammonia) or nitrogen (dlphenylphosphoryl azide, followed by reduction, such as with REDAL) provides access, by subsequent derivatlsation to derivatives where R4 is CO2R1; CON(R1)2 (where each R4 is the same or different); CH2OR1 (If), S02N(R1)2 (1g, where each Ri is the same or different); and NR1COR5; NR1SO2R5 (1h); NR1CO2R5; NRiGON(R1)2 (where each R1 is the same or different). Examples are given in Scheme 3. (SCHEME REMOVED) In addition, compounds of general formula (1) where either W, X,Y or Z is CR4 and R4 is a halogen such as Br (1a) can undergo palladium-catalysed coupling reactions with carbon-based coupling partneR5. Thus, compounds of general formula (1) where either W, X, Y or Z is CR4 and R4 is a halogen such as Br can be coupled to alkenes of a general type CH2=CHR4 under Heck conditions, alkynes of a general type CH=CHR4 under Sonogoshira conditions, or metalloheterocycles e.g. where the metal is tin, under Stills coupling conditions. This gives access to compounds where either W, X, Y or Z can be C2-C6 alkenyl substituted with R4 (11) C2-C6 alkynyl substituted with R4 (1j) and where R4 is a five membered aromatic heterocycie containing 1-4 heteroatoms taken from N (such as in pyrrole, diazoles, triazoles or tetrazoles for example) and O (such as in furan (1k), oxazoies or oxadiazoles for example). Such coupling reactions ensure that CHains and rings are linked either through carbon. Examples are in Scheme 4. (SCHEME REMOVED) In addition to the examples described above, additional compounds of formula (1) rnay be prepared by interconversion of other compounds of formula (1). Thus, for example, a compound of formula (11) wherein R4 is a C1-6 alky! group may be prepared by hydrogenation (using palladium on carbon In suitable solvent, such as an alcohol - e.g. ethanol) of a compound of formula (1i) wherein R4 IS a C2-6 aikenyl group (e.g. as in Scheme 5). Scheme 5: (SCHEME REMOVED) Any mixtures of final products or intermediates obtained can be separated on the basis of the physico-chemical differences of the constituents, In Known manner, into the pi ire final products or internrediates, for example by chromatography, distillation, fractional crystallization, or by formation of a salt if appropriate or possible under the circumstances. The compounds according to the invention exhibit in vitro inhibiting activities with respect to monoamine (i.e. noradrenaline, serotonin and dopamine) reuptake. The activity and selectivity of the compounds may be determined by use of an appropriate monoamine reuptake assay. This invention also relates to a method of treatment for patients (including man and/or mammalian animals raised in the dairy, meat or fur industries or as pets) suffering from disorders or diseases which can be attributed to monoamine reuptake as previously described, and more specifically, a method of treatment involving the administration of the monoamine reuptake inhibitor of fomiuia Accordingly, the compounds of formula (1) can be used among other things in the treatment of pain and emesis but also may find utility in a range of other therapeutic indications such as depression, post traumatic stress disorders, attention deficit disorders, obsessive compulsive disorders, premenstrual syndrome, substance abuse and sexual dysfunction; a method of management (by which is meant treatment of prophyiaxis) of disease or conditions mediated by monoamine reuptake in mammals, in particular in humans, which method comprises administering to the mammal an effective, amount of a compound of formula (1) above, or a pharmaceutically acceptable salt thereof; and a compound of formula (1) for use in human or veterinary medicine, particularly in the management (by which is meant treatment or prophylaxis) of diseases or conditions mediated by monoamine reuptake; and the use of a compound of formula (1) in the preparation of an agent for the management (by which Is meant treatment or prophylaxis) of diseases or conditions mediated by monoamine reuptake. The disease or conditions referred to above include pain, emesis depression, post traumatic stress disorders, attention deficit disorders, obsessive compulsive disorders, pre-menstrual syndrome, substance abuse and sexual dysfunction. Compunds of formula (1) may be administered orally, topically, buccaily, ocularly, rectally, vaginally, parenterally, intra-nasally, sublipgually or by inhalation spray, e.g. in dosage unit formulation? containing non-toxic pharmaceuticaliy acceptable carriers, adjuvants and vehicles. The term parenteral as used herein includes subcutaneous Injections, intravenous, intramuscular, intrasternal injection or infusion techniques. In adcltion to the treatment of warm-blooded animals such as mice, rats, horses, cattle, sheep, dogs, cats etc, the compounds of the invention are effective in the treatment of humans. The pharmaceutical composition containing the active ingredient may be in a form suitable for oral use, for example, as tablets, troches, lozenges, aqueous or oily suspensions, dispersible powders or granules, emulsions, hard or soft capsules, or syrups or elixiR5. The composition may be in immediate or controlled release form. Compositions intended for oral use may be prepared according to any method known to the art for the manufacture of pharmaceutical compositions and such compositions may contain one or more agents selected from the group consisting of sweetening agents, flavouring agents, colouring agents and preserving agents in order to provide pharmaceutically elegant and palatable preparations. Tablets contain the active ingredient in admixture with non-toxic pharmaceutically acceptable excipients which are suitable for the manufacture of tablets. These excipients may be for example, inert diluents, such as calcium carbonate, sodium carbonate, lactose, calcium phosphate or sodium phosphate; granulating and disintegrating agents, for example corn starch, or alginic acid; binding agents, for example starch, gelatin or acacia, and lubricating agents, for example magnesium stearate, stearic acid or talc. The tablets may be uncoated or they may be coated by known techniques to delay disintegration and absorption In the gastointestinal tract and thereby provide a sustained action over a longer period. For example, a time delay material such as glyceryl monostearate or glyeryl distearate may be employed. They may also be coated by the techniques descrbed in the US Patents 4,2*56.108;4.166,452; snd 4,266.874 to form osmotic therapeutic tablets for control release. Formulations for oral use may also be presented as hard gelatin capsules where in the active ingredient is mixed with an inert solid diluent, for exannple calcium carbonate, calcium phosphate or kaolin, or as soft gelatin capsules wherein the active ingredient is mixed with water or an oil medium, for example peanut oil, liquid paraffin or olive oil. Aqueous suspensions contain the active materials in admixture with excipients suitable for the manufacture of aqueous suspensions. Such excipients are suspending agents, for example sodium carboxymethylcelluiose, methylcellulose, hydroxypropylmethylcelkjjose, sodium alginate polyvinyl- pyrrolidone, gum tragacanth and gum acacia; dispersing or wetting agents may be a naturally occuring phosphatide, for example lecithin, or condensation products of an alkylene oxide with fatty acids, for example polyoxyethylene stearate, or condensation products of ethylene oxide with long CHain aliphatic alcohols, for example heptadecaethyleneoxycetanol, orcorKiensation products of ethylene oxide with partial esters dervied from fatty acids and a hexitol such a polyoxyethylene with partial esters derived from fatty acids and hexitol anhydrides, for example polyoxyethylene sorbitan monooleate. The aqueous suspensions may also contain one or more preservatives, for example ethyl or n-propyl p-hydroxybenzoate, one or more colouring agents, one or more flavouring agents, and one or more sweetening agents, such as sucrose or sacCHarin. Oily suspensions may be formulated by suspending the active ingredient in a vegetable oil, for example arachis oil, olive oil, sesame oil or coconut oil, or in a mineral oil such as liquid paraffin. The oily suspensions may contain a thickening agent, for example beeswax, hard paraffin or cetyl alcohol. Sweetening agents such as those set forth above, and flavouring agents may be added to provide a palatable oral preparation. These compositions may be preserved by the addition of an anti-oxidant such as ascorbto ackl. Dispersible powders and granules suitable for preparation of an aqueous suspension by the addition of water provide the active ingredient in admixture with a disfjersing or wetting agent, suspending agent and one or more preservatives. Suitable dispersing or wetting agents and suspendlng agents are exemplified, for example sweetening, flavouring and colouring agents, may also be present. The pharmaceutical compositions of the invention may also be in the form of oil-in-water emulsions. The oily phase may be a vegetable oil, for example olive oil or arachis oil, or a mineral oil, for example liquid paraffin or mixtures of these. Suitable emulsifying agents may be naturelly-oocuring gums, for example gum acacia or gum tragacanth, naturally-occuring phosphatides, for example soya bean, lecithin, and esters or partial esters derived from fatty acids and hexitol anhydrides, for example sorbitan monooleate and condensation products of the said partial esters with ethylene oxide, for example polyoxyethylene sorbitan monooleate. The emulsions may also contain sweetening and flavouring agents. Syrups and elixirs may be formulated with sweetening agents, for example gycerot, propylene glycol, sorbitol or sucrose. Such formulations may also contain a demulcent, a preservative and flavouring and colouring agents. The pharmaceutical compositions may be in the form of a sterile injectable aqueous or oJeagenous suspension. This suspension may be formulated according to the known art using those suitable dispersing or wetting agents and suspending agents which have been mentioned above. The sterile injectable preparation may also be in a sterile injectable solution or suspension in a non-toxic parenteraJly-acceptable diluent or solvent, for example as a solution in 1,3-butanediol. Among the acceptable vehicles and solvents that may be employed are water, Ringer's solution and isotonic sodium chloride solution. In addition, sterile, fixed oils are conventionally employed as a solvent or suspending medium. For this purpose any bland fixed oil may be eruptoyed iixiiuding synthetic mono- or diglycerides. In addition, fatty acids such as oleic acid find use in the preparation of injectables. The compounds of formula (1) may also be administered in the form of suppositories for rectal administration of the drug. These composKlons can be prepared by mixing the drug with a suitable non-irritating excipient which is solid at ordinary temperatures but liquid at the rectal temperature and will therefore melt in the rectum to release the drug. Such materials are cocoa butter aci polyethylene glycols. For topical use, creams, ointments, jellies, solutions or suspensions, etc containing the compounds of Formula (1) are employed. For the purposes of this application, topical application includes mouth washes and gargles. Dosage levels of the order of from about 0.05 mg to about 140 mg per kilogram of body weight per day are useful in the treatment of the above-indicated conditions (about 2.5 mg to about 7 gms per patient per day). For example, emesis may be effectively treated by the administration of from about 0.01 to 50 mg of the compound per kilogram of body weight per day (about 0.5 mg to about 3.5 gms per patient per day). The amount of active ingredient that may be combined with the carrier materials to produce a single dosage form will vary depending upon the host treated and the particular mode of administration. For example, a formulation intended for the oral administration of humans may vary from about 5 to about 95 percent of the total composition. Dosage unit forms will generally contain between from about 1 mg to about 500 mg of an active ingredient. It will be understood, however, that the specific dose level for any particular patient will depend upon a variety of factors including the activity of the specifrc compound employed, the age, body weight, general health, sex, diet time of administration, route of administration, rate of excretion, drug combination and the severity of the particular disease undergoing therapy. The following Examples illustrate the invention. Experimental 2-Benzoy!-4-bromoben2olc acid (2a) and 2-Ben2oyl-6-bromobenzolc acid (2b) (Formula Removed) A mixture or 4-bromophthalic anhydride (1) (8.6g, 37.9mmol) and aluminium chloride (10g, 75mmol, 2 equiv.) were heated under reflux for six hours under an atmosphere of nitrogen. The hot reaction mixture was poured into a solution of water: cone, hydrochloric acid (9:1, 200mL) and the aqueous layer extracted with dichloromethane (2x150mL). The organic extract was dried over magnesium sulphate, filtered and evaporated under reduced pressure to furnish the crude product as an off white solid. The solid was dissolved in ethanol (80mL) and water added until the solution remained turbid. The mixture was allowed to stand at room temperature for four hours; the precipitate formed was filtered, washed with hexane (2 x 10mL) and dried under suction to furnishcompound 2a. Yield 4.1g, 35%. 1H nmr (250MHz, CDCI3); 7.94 (1H. d. J 8.0, CHar). 7.71 (3H. m. CHar). 7.58 (1H. t. J 7.5. CHar). 7.61 (1H, d. J1.5CHar), 7.44 (2H. t. J 7.5. CHar). 7.0-6.4 (1H, bs, Old). The mother liquors were concentrated under reduced pressure to half the volume and stirred at room temperature. The precipitate formed was filtered, washed with hexane (2 x 10mL) and dried under suction to provide 2b. Yield 4.8g, 42% 1H nmr (250MHz. CDCb); 8.70-8.30 (1H. bs, Oh), 8.20 (1H. d, J 1.5, CHar). 7.80 (2H. dd, J 8.0, 1.5, CHar). 7.71 (2H, m. CHar), 7.58 (1H, m. CHar), 7.44 (2H, m, CHar). 7.26 (1H, d, J 8.0 CHar). N(2-hydroxyethyi)-N-methyl- 2-benzoyl-4-bronriobenzamide (3a) (Formula Removed) A solution of 2M oxalyl chloride (3.69mL, 7.38mmol, 1.1 equiv.) in dichloromethane was added dropwise to a suspension of compound 2a in dichloromethane (12mL) and catalytic N, N-dtmethytformamide (2 drops) at room temperature under a nitrogen atmosphere. Gas evolution was rapid and as the reaction proceeded the solid dissolved in the dich'oromethane. After 2.5 hours the solvent was removed under reduced pressure and the resulting solid co-evaporated with dichloromethane (2 x 20mL) to remove traces of excess oxalyl chloride. The crude acid chloride was dissolved in dichloromethane (15mL) and added dropwise to a solution of A/-methylaminoethanol (593faL, 7.38mmcl, 1.1 equiv.) and triethylamlne, (1.03mL, 7.38mmol, 1.1 equiv) in dichloromethane (15mL) cooled to 0°C in an ice bath. The resulting solution was stirred at room temperature for 3 hours, quenched with saturated aqueous sodium dicarbonate (20mL) and separated. The aqueous layer was extracted with dichloromethane (30mL) and the combined organic fractions washed with brine {20mL), dried over magnesium sulfate and filtered. The solvent was removed under reduced pressure and the crude product purified by column clirotnatography, eiutlng with ethyl acetate : hexane {4:1). followed by ethyl acetate (100%) as product eluted. Compound 3a was furnished as a semi solid. Yield 2.23g, 92%. The product exists are a mixture of rotomers in a 3:2 ratio. 1H nmr (250MH2. CDCIa); 7.85 (2H, m, CHar). 7.75-7.62 (3H. m, CHar), 7.34 (0.6H. J 8.0. CHar). 7.33 (0.4H. J 8.0. CHar), 3.83 (1.2H. t. J 4.5, CH2-OH), 3.76 (O.BH, t, J4.5, CH2OH), 3.59 (2H, t, J 4.5. NCHb). 3.08 (0.4H, s, CHar)2.99 (0.6H. s, CHar). 2.45 (1H, bs. OH). N-(2-hydroxyethyI)-N-methyl- 2-benzoyl-5-bromobenzamicle (3b) (Formula Removed) A solution of oxalyl chloride (6.5mL, 74.3mmol, 1,1 oquiv.) in dichloromethane (150mL) was added dropwise to a suspension of compound 2a (20.6g, 67.5mmol, ratio of 3:1 of 2a:2b respectively) in dichloromethane (50mL) and catalytic N,N-dimethylformamide (4 drops) at room temperature under a nitrogen atmosphere. Gas evolution was rapid and as the reaction proceeded the solid dissolved in the dichloromethane. After 2.5 hours the solvent was removed under reduced pressure and the resulting solid co-evaporated with dichloromethane (2 x 50mL) to remove traces of excess oxalyl chloride. The crude acid chloride was dissolved in dich'oromethane (l00mL) and added dropwise to a solution of A/-methylaminoethanol (6mL, 74.3mmol, 1.1 equiv.) and triethylamine, (10.4mL, 74.3mmol, 1.1 equiv) In dichloromethane (1S0mL) cooled to CC in an ice bath. The resulting solution was stirred at room temperature for 3 hours, quenched with saturated brine (lOOmL) and separated. The aqueous layer was extracted with dichloromethane (2 x 50mL) and the combined organic fractions washed with brine (1 OOmL), dried over magnesium sulfate and filtered. The solvent was removed under reduced pressure and the crude product purified by column chromatography, eluting with ethyl acetate : hexane (4:1) to elute compound 3b. Yield 6.2g. 25%. Eluting with ethyl acetate (100%) furnished compound 3a as a semi solid. Yield 14.6g, 60%. The product exists are a mixture of rotomers in a 3:2 ratio. 1H nmr (250MH2. CDCI3); 7.78 (1.8H. m, CHar), 7.60 (2.7H. m. CHar. 7.49 (2.5H. CHar). 7.45 (0.4H, d. J 8.5, CHar). 7.37 (0.6H. d, J 8.5, CHar), 3.86 (1.2H. m, CH2OH), 3.76 (0.8H. m. CH2OH). 3.61 (2H. m. CHar). 3.08 (0.4H, s. NCH3), 3.00 (0.6H. s. NCH3). N-(2-hydroxyethyl)-N-niethyl- 4-foromo-2-(1 -hydroxy-1 -phenyl )methy I benzyl amine (4a) (Formula Removed) Amide 3a (13,8g, 38mmol) was dissolved in tetrahydrofuran (75mL) and cooled to 0°C in an ice bath. A 2M solution of borane dimethylsulfide complex (84mL, 168mmol, 4.4 equiv.) was added dropwise and the resulting solution stin-ed at room temperature for 17 houR5. The reaction was carefully quenched with 6M hydrochloric acid solution (84mL) and the resulting solution heated under reflux for 1 hour. Tetrahydrofuran was removed under reduced pressure and remaining solution diluted with water (70mL) and extracted with diethyl ether (2x1 100mL). The aqueous layer was basified with 3.75M sodium hydroxide solution and extracted with ethyl acetate (2 x 200mL). The combined ethyl acetate extracts were dried over magnesium sulfate, filtered and evaporated under reduced pressure to furnish the desired product 4a as a colourless glass. Yield 10.2g. 77%. 1H nmr (250MHz, CDCia); 7.38-7.27 (7H, m, CHar). 7.08 (1H, d. J 8.0, CH.r), 6.83 (1H, s. CHOH), 3.70-3.65 (2H. m, OClHz). 3.41 (1H, d, J 12.5, ArCHaHbN). 3.29 (1H. d, J 12.5. ArCHaidbN), 2.58-2.55 (2H, m, NCHb), 2.21 (3H. s, NCHa). N(-(2-hydroxyethyl)-N-methyl- 5-bromo-2-(1 -hydroxy-1 -phenyl)methyl benzylamine (4b) (Formula Removed) Amide 3b (7.4g, 20.4mmol) was dissolved in tetraiiydrofuran (40mL) and cooled to 0°C in an Ice bath. A 2M solution of borane dimethyjsutfide complex (45mL, 90mmol, 4.4 equiv.) was added dropwise and the resulting solution stirred at room temperature for 17 houR5. The reaction was carefully quenched with 6M hydrochloric acid solution (45mL) and the resulting solution heated under reflux for 1 hour. Tetrahydrofuran was removed under reduced pressure and the remaining solution was diluted with water (45mL) and extracted with diethyl ether (3 x 50mL). The aqueous layer was basified with 3.75M sodium hydroxide solution and extracted with ethyl acetate (2x100mL). The combined ethyl acetate extracts were dried over magnesium sutfate, filtered and evaporated under reduced pressure to furnish the desired product 4b as a colourless glass. Yield 6.5g, 91%. 1H nmr (250MHz, CDCl3); 7.41-7.27 (7H, m. CHar). 7.06 (1H, d, J 8.0. CH.r). 5.86 (1H. s, CHCH). 3.72-3.66 (2H. m, OCH2). 3.44 (1H. d. J 12.5. ArCHaHbN). 3.32 (1H, d, J 12.5, ArCH,HbN), 2.59 (2H, m. NCH2), 2.23 (3H, s. NCH3). 9-Bromo-5-methyl-1 -phenyl-1,3,4,6-tetrahydro-6H-ben2[f]-2,5-oxazocine (5a) (Formula Removed) Diol 4a {14.6g, 41.6mmol) was dissolved in toluene (115mL) and para-toluenesuifonlc acid monohydrate (11.9g, 62.4mmol, I.Sequiv.) added. The toluene was removed under reduced pressure and the resulting oil heated at 105*C for 4 houR5. On cooling the oil was suspended in water (100mL) and basified with 3.75M sodium hydroxide solution. The aqueous layer was extracted with ethyl acetate (2 x 200mL), dried over magnesium sulfate, filtered and evaporated under reduced pressure to furnish the product 5a as pale brown oil. Yield 9.25g, 67%. 1H nmr (250MHz, CDCI3); 7.38-7.26 (5H. m. Cil.r). 7.11 (2H. t, J8.0, Cij»). 5.72 (1H. s. CHO). 4.82 (1H. d. J 13.0, ArCJiNb). 4.19 (1H, dt, J 3.0, 8.0, OCJdUHb). 3.82 (1H, ddd. J 3.0, 6.0, 13.0, OCHJdb). 3.62 (1H, d, J 13.0, ArCHJdb). 2.81 (1H, m NCiiHb). 2.61 (1H, ddd, J 3.0, 8.0, 13.0, NCHJi,), 2.43 (3H. s, CtU). 8-Bromo-5-methyl-1 -phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,6-oxazoclne (Formula Removed) Diol 4b (6.5g, 18.6mmol) was dissolved in toluene (50mL) and para- toluenesulfonic acid monohydrate (5.3g, 27.8mmol, I.Sequiv.) added. The toluene was removed under reduced pressure and the resulting oil heated at 105°0 for 4 houR5. On cooling the oil was dissolved in 3.75M sodium hydroxide solution and extracted with ethyl acetate (2 x BOmL), dried over magnesium sulfate, filtered and evaporated under reduced pressure to furnish the crude product. The crude product was purified by dry flash chromatography eluting with ethyl acetate (100%, followed by ethyl acetate.methanol (5%)). Fractions containing product were connbined and evaporated under reduced pressure to furnish 5b as pale brown oil. Yield 3.6g, 58%. 1H nmr (250MHz, CDCI3); 7.37-7.22 (7H, m, CHar). 6.86 {1H, d. J 8.0. CHar). 5.74 (1H, s. CHO), 4.79 (1H. d, 13.0, ArCHaHb), 4.16 (1H, dt, J3.0. 8.0, OCHaHb), 3.85 (1H. ddd. J 2.0, 6.0. 13.0, OCHaHb), 3.61 (1H, d, J 13.0. ArCHJdb). 2.81(1H. ddd. J 2.0. 8.0. 13.0, NC1-6Hb). 2.63 (1H. ddd. J 3.0, 6.0, 13.0, NCHaHb). 2.46 (3H. s, CMa). 9-Cyano-5-methyl-1 -phenyl-1.3,4,6-tetrahydro-6H-benz[f]-2,5-oxazoclne (6a) (Formula Removed) Bromo analogue 5a (0.2g, 0.6mmol), Zn(CN)2 (53mg, 0.6mmol), and Pd(PPh3)4 (34mg, 0.03mmol), were dissolved in degassed anhydrous DMF (3mL) under a Na atmosphere. The mixture was refluxed under N2for 24 houR5. The mixture was allowed to coot to room temperatuR6, filtered through celite and washed through with DCM (50ml). The filtrate was then quenched with vvaler (10ml) and solvent extracted. The organic extract was dried over MgSo4. filtered and solvent removed under reduced pressure. The crude product was purified by dry flash chromatography ©luting with DCM: MeOH (98:2). Fractions containing the product were combined and evaporated under reduced pressure to produce 6a as pale brown oil. Yield 106mg, 63%. 1H nmr (250MHz, CDCb); 7.51 (1H. dd, J2.0. 8.0. Cjir). 7.36-7.23 (7H, m, CHar), 5.79 (IH, s, CHO), 4.90 (1H, d, J 13.0. ArCH.Hb). 4.26-4.16 (1H, m. OCH.Hb), 3.66 (1H, ddd. J 3.0, 6.0, 13.0. OCH,Hb), 3.71 (1H, d. J 13.0, ArCHJHb), 2.78(1 H. ddd. J 3.0. 8.0. 13.0, NCH.Hb), 2.68 (IH. ddd, J 3.0, 5.0, 13.0, NCHaHb). 2.45 (3H, s. CH3). 8-Cyano-5-methy 1-1 -phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxa20Clne (6b) (Formula Removed) Bromo analogue 5b (0.2g, 0.6mmol), 2n(CN)2 (53mg, 0.6mmol), and Pd(PPh3)4 (34mg. O.OSmmol), were dissolved in degassed anhydrous DMF (3mL) under a Nz atmosphere. The mixture was refiuxed under N2 for 24 houR5. There is no CHange in Rf value for compound 6b from the starting material 5b. Completion of the reaction can only be determined by 1H nmr. The mixture was allowed to cool to room temperatuR6, filtered through celite and washed through with DCM (50ml). The filtrate was quenched with water (10ml) and solvent extracted. The organic extract was dried over MgSo4, filtered and solvent removed under reduced pressure. The crude product was purified by dry flash chromatography eluting with DCM: MeOH (98:2). Fractions containing the product were combined and evaporated under reduced pressure to produce 6b as pale brown oil. Yield 110mg, 66%. 1H nmr .250MHz, C- Ch); 7.46 (2H, td, J 2.0, 8.0, CHar. 7.31 (6-1, m. CHar), 7.10 (1H, d, J8.0, CHar). 6.76 (1H, s, CJdO). 4.97 (1H, d. J 13.0, ArCHaHb), 4.25 (1H. ddd, J 3.0. 8.0. 13.0, CHar), 3.82 (1H, ddd. J 3.0, 5.0. 13.0, ArCHaHb). 3.62 (1H, d, J 13.0. NCHaHb). 2.74(1 H, ddd. J2.0, 8.0. 13.0, NCHaHb), 2.44 (3H. s. CHar). 5-methyl-1 -phenyl-1,3,4,6-tetrahydro-5H-benz[fl-2,5-oxazocine-9- (Formula Removed) Finely ground potassium hydroxide (130mg, 2.32mmol) in tertiary butanol (4ml) was added to nitrile 6a (169mg, 0.61 mmot). The solution was heated under reflux for 1.5 hours with stirring. On cooling, the reaction was diluted with brine (12.5ml) and extracted with chloroform (3 x 10ml). The combined organic layers were washed with brine (2 x 5ml), dried over potassium carbonate and concentrated under reduced pressure to yield a yellow solid. Flash column chromatography (15%-25% methanol in ethyl acetate) furnished amide Ta-as a cream coloured solid. Yield 195mg, quantitative yield. IR(vmax/cm-1)1656; 1H nmr (250MHz. CDsOD); 7.75 (1H. dd, J 7.9, 1.8, CHar). 7.60 (1H. d. J 1.5, CHar), 7.36 (1H, d, J 8.0. CHar). 7.28 (5H. brs, CHar). 5.86 (1H, s, CHar), 6.02 (1H. d, J 12.5, ArCHaHb). 4.22 (1H, m. OCHaHb). 3.88 (1H,dq, J 12.7. 4.7, 2.5. OCHaHb), 3.72 (1H. d, J 12.5. ArCHaHb). 2.76 (1H. m, NCtl.Hb). 2.56 (1H, dq, J 14.2. 3.1. NHaHb). 2.43 (3H. s, NCH3). 5-methyl-1-phenyl-1,3,4.6-tetrahydro-5H-benz[f]-2,5-oxazocine-8-carboxamide (7b) (Formula Removed) Finely ground potassium hydroxide (87mg, 1 .SSmmol) in tertiary butanol (4ml) was added to nitrile 6b (135mg. 0.49mmol). The solution was heated under reflux for 1.5 hours with stirring. On cooling, the reaction was diluted with brine (12.5ml) and extracted with chloroform (3x10ml). The combined organic layers were washed with brine (2 x 5ml), dried over potassium carbonate and concentrated under reduced pressure to yield a yellow solid. Flash column chromatography (15%-25% methanol in ethyl acetate) furnished amide 7b as a cream coloured solid. Yield 140mg. 97%. 1H nmr (250MHz, CD3OD); 7.74-7.63 (2H. m, CHar), 7.25-7.09 (6H. m, CHar). 5.80 (1H. s. ChiO), 4.96 (1H, d, J 10.1. ArCHaCHb), 4.25 (1H, d. J 10.0, ArCH.CHb), 3.89-3.65 {2H. m, OC!d.Hb). 2.83 (1H. m, NCidaHb), 2.S6 (1H. m. NCHaJdb). 2.53 (3H, s, NCHa). N-(1,1,1 -trimethylmethoxycarbonyl)-5-methyl-1 -phenyl-1,3,4,6-tetrahydro-5H benz[f]-2,5-oxazocine-9-methylamine (8a) (Formula Removed) Sodium borohydride (260mg, 6.61 mmol) was cautiously added to a solution of nickel chloride {122mg, 0.94mmol), B0C2O (412mg, 1.89mmol) and nitrile 6a (260mg, 0,94mmol) in anhydrous methanol (10ml) at 0*C. Once the vigorous initial reaction had subsided, the mixture was left to stir ovennight under a nitrogen atmosphere at room temperature. The methanol was removed under reduced pressure and the resulting precipitate dissolved in ethyl acetate. Saturated aqueous sodium bicarbonate was added, the mixture sonicated and the resulting precipitate filtered. The organic layer was separated from the aqueous which was extracted with ethyl aceicvate (2x l0nL). The combined organic layers were dried over sodium sulfate and concentrated under reduced pressure to yield a brown oil. Flash column chromatography (5%-10% methanol in dichloromethane) fumished protected amine 8a as an orange/brown oil. Yield 141 mg, 39%. 1H nmr (250MHz. CDCI3); 7.29-7.15 (7H, m. CHar). 6.88 (H, s, CHar), 5.74 (1H, s, CaO), 4.79 (1H, d, J 13. ArCHaCHb). 4.19-4.17 (3H, m. CHa, OCHaHb), 3.83 (1H, d, J2, 6, 13, ArCHaCHb). 3.65 (1H. d, J 13.0. NCHaCHb) 2 78 (1H. ddd, J 2. 8, 15. OCHaCHb). 2.61 (1H. ddd, J 2, 6. 15. NCHalHb). 2.43 {3H. s. CH3). 1.45 (9H, s, Boc. 'Bu). N-(1,1,1-trimethylmethoxycarbonyl)-6-methyl-1-phenyl-1,3,4,6-tetrahydro-5H-benz[f3-2,5-oxazoclne-8-methylamine (8b) (Formula Removed) Sodium borohydride (470mg, 12.6mmol) was cautiously added to a solution of nickel chloride (460mg, 3.6mmol), B0C2O (780mg, 3.6mmof) and nitrile 6a (500mg, 1.8mmol) in anhydrous methanol (20mi) at 0°C. Once the vigorous initial reaction had subsided, the mixture was left to stir overnight under a nitrogen atmosphere at room temperature. The methanol was removed under reduced pressure and the resulting precipitate dissolved in ethyl acetate. Saturated aqueous sodium bicarbonate was added, the mixture sonicated and the resulting precipitate filtered. The organic layer was separated from the aqueous which was extracted with ethyl acetate (2 x 10mL). The combined organic layers were dried over sodium sulfate and concentrated under reduced pressure to yield a brown oil. Flash column chromatography (5%-10% methanol in dichloromethane) furnished protected amine 8b as an orange/brown oil. Yield 260mg, 48%. 1H nrPi (260MHz, CDCIa); 7.30-7.16 (7H. m, CHaO. 6.90 (H, s, CH,r),5.74 (1H. s. CilO), 4.83 (1H, d, J 12.8, ArCHaCHb), 4.77 (H. bR5. NH), 4.23 (3H, m. CH2, OCHaCHb), 3.87(1H, ddd, J 2. 5, 13, ArCHaCHb). 3.69 (1H. d, J 13.0, NCHaCHb) 2.81 (1H, m. CHaCHb). 2.64 (1H, ddd, J 3, 5, 14 NCHaCHb). 2.47 (3H, s, CH3). 1.42 (9H. s, Boc, 'Bu). 5-methyl-1,9-dlphenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazoclne (9a) (Formula Removed) To a solution of 6a (280mg, 0.84mmol) in dimethoxyethane (20mL) and the organic layer dried over MgSo4. Filtration and evaporation under reduced pressure furnished a brovwi oil. Diethyl ether (25mL) was added and a precipitate formed. After filtration the filtrate was evaporated under reduced pressure and the resulting oil purified by column chromatography, eluting with diethyl ether : methanol (4:1). Fractions containing product were combined, evapoorted under reduced pressure to furnish the desired product as a pale yellow oil. Yield 172mg, 61%. 1H nmr (250MHz, CDCb); 7.52-7.47 (3H. m. Clir). 7.43-7.26 (10H, m, CHar), 6.87 (1H, s, CHO). 4.88 (1H, d. J 12.5, ArCHaCHb), 4.24 (1H, m, OCHaCHb), 3.92 (1H, m. OCHaCHb). 3.72 (1H, d, J 12.5, ArCH,Ctib). 2.89 (1H, m, CHaCHb), 2.68 (1H. m, CHaCHb). 2.51 (3H, s. NCHs). 5-nnethyl-1,8-diphenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine (9b) (Formula Removed) To a three neck flask containing 5b (200mg, 0.72mmol) In toluene (4ml) under a nitrogen atmosphere at room temperature was added tetrakis(triphenylphosphine) palladium (106mg, O.OSmmol). After stirring for 10mins, Caesium carbonate (1.4g, 4.32mmol) was added followed by phenylboronic acid (96mg, 0.93mmol). The reaction was refluxed at 1 10°C for 3 houR5. When cooled, the reaction was filtered through celite which was subsequently washed with ethyl acetate. The organic layer was then separated from the aqueous and dried over MgSO4 The crude compound was concentration under reduced pressure and purified using column chromatography eluted with EtOAc to produce the pure compound as an off white solid . Yield 55mg, 23%. 1H nmr (250MHz, CDCIa); 7.50 (2H, d, J 7.2, CHar). 7.46-7.29 (10H, m. CHar). 7.07 (1H. d, J 7.a, CH,r), 5.84 (1H. s, CHO). 4.90 (1H, d. J 12.8. ArCHaCHb). 4.23 (1H, td. J 10.5. 2.6. OCHaCHb). 3.91 (1H, ddd. J 12.5. 5.7. 2.1. OCHaCHb), 3.79 (1H. d. J 12.7. ArCHaCHb). 2.90 (1H. ddd, J 14.2. 8.4. 2.1. NCHaCHb). 2.68 (1H. ddd, J 14.1. 5.6. 2.5, NCHaCHb). 2.52 (3H. s. NCH3). 9-(3,5-dimethylisoxazol-4-yr)-5-methyl-1-phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine (10a) (Formula Removed) To a three neck flask containing 5a (300mg, 0.91 mmol) In DME (4ml) under a nitrogen atmosphere at room temperature was added tatrakis(triphenylphosphine) palladium (105mg, 0.09mmol). After stirring for 10 mins, Na2C03 (576mg. 5.44mmoi) dissolved in water (2ml) was added followed by 3,5-dimethyl-4-lsoxazolylboronic acid (166mg, 1.18mmol). The reaction was refluxed at 85°C for 2 houR5. When cooled, the reaction was filtered through celite which was subsequently washed with ethyl acetate. The organic layer was then separated from the aqueous and dried over MgSo4. Concentration under reduced pressure and column chromatography (10% MeOH in DCM) gave a brown oil. Yield 304mg, 97%. 1H nmr (260MHz, CDCI3); 7.28 (6H, m, CHar). 7.13 (1H. dd, J 7.6. 1.5, CHar), 6.85 (1H. d. J 1.1, CHar), 5.84 (1H. s, CHO). 4.76 (1H. d. J 12.8. ArCH.CHb). 4.19 (1H. m. OCHaCHb), 3.90 (1H, m, OCHaCHb ). 3.73.(1H. d. J 12.8, ArCHaCHb). 2.89 (1H, ddd, d, J 14.1. 7.9, 1.8, NCHaCHb). 2.68 (1H. ddd, J 14.1, 6.1. 2.2,* NCHaCHb), 2.50 (3H. s, NCH3). 2.26 (3H, s, CJia), 2.12 (3H, s, CH3). 8-(3,5-dlmethylisoxazol-4-yI)-5-methyl-1-phenyl-1,3.4,6-tetrahydro-5H-benzIfI-2,5-oxazocine (10b) (Formula Removed) To a three neck flask containing 6b (382mg, 1.16mmol) in DME 1H nmr (250MHz. CDCI3); 7.30 (5H, m,CHar). 7.08 (3H, m, CHar). 5.82 (1H, s. CtiO), 4.88 (1H, d, J 12.8, ArCHaCHb). 4.21 (1H. m, OCHaCHb). 3.89 (1H. ddd. J 12.6, 5.7. 2.2, OCHaCHb ). 3.72 (1H. d, J 13.0, ArCHaCHb). 2.86 (1H. ddd, d, J 14.2, 8.3, 2.2, NCliCHb), 2.67 (1H. ddd, J 14.2, 5.7, 2.6, NCH.Cldb), 2.47 (3H, s, NCMs), 2.41 (3H, s, CH3). 2.27 (3H. S. CH,). 2-(5-methyl-1-phenyI-1,3,4,6-tetrahydro-5H-ben2[f]-2,5-oxazoclne-9- ethenyi)carboxamide (11a} (Formula Removed) To a sample vial containing a solution of 5a (245mg, 0.74mmol), in DMF (3mf) was added acryiamide (105mg, 1.47mmol), foliowed by Pd(OAc)2 (17mg, 0.074mmol), P(o-toly|)3 (64mg, 0.21 mmol). NaOAc (73mg. 0.68mmol), LiCI (63mg. 1.47mmol), K2CO3 (122mg, 0.88mmol), and water (300µL) sequentially. The reaction vial was sealed and placed in a personal chemistry MFcrowave, Emrys optimiser at 140°C for 4 min. On cooling, the compound was purified by column chromatography, gradient elution of DCM; MeOH (5%, 10%, 15% and finally 20%). The compound was isolated as a colourless solid, (138mg, 58% yield). 1H nmr (250MHz. CDCU): 7.50 (H. d, J 16.8, ChUCONH), 7.46-7.21 (7H. m. CtUr)..7.12 (H. d, jR6, CHar)^,6.34 (H, d.J 16.8, CHbCONH) 5.78 NJdz.CidO). 4.83 (1H. d. J 13.8. ArCHaCHb), 4.20 (1H. ddd, J 13,6, 9.2, 2.9 OCJipHb), 3.85 (1H, ddd, J 13.5. 5.9, 2.3, OCH.Cji, ). 3.72 (1H, d. J 13.8, ArCH.Ctlb). 2.82 (1H, ddd, d, J 15.1, 8.9, 2.3, NCtUCHb), 2.64 (1H, ddd, J 15,4, 6.2. 2.9 NCH.CJib). 2.46 (3H, s. NCh3). 2-(5-methyl-1-phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine-8-ethenyl)carboxamlde (11b) (Formula Removed) To a sample vial containing a solution of 5b (3ml) was added acrylamide (106mg. 1.47mmol), followed hy Pd(OAc)2 (17mg, 0.07mmol). P(o-tolyl)3 (64mg. 0,21 mmol), NaOAc (73mg. 0.88mmol), LiCI (63mg, 1.47mmol), K2CO3 (122mg, 0.88mmol), and water (300µL) sequentially. The reaction vial was sealed and placed in a personal chemistry Microwave, Emrys optimiser at 140°C for 4 min. On cooling, the compound was purified by column chromatography, gradient elution of DCM; MeOH (5%, 10%, 15% and finally 20% to elute the product). The compound was isolated as a colourless solid. (51 mg. 21% yield). 1H nmr (250MHz, CDCIa); 7.62 (H, d, J 15.6. CHaCONH). 7.39-7.26 (7H, m, Cidar), 7.03 (H, d. J 8.1 CJHar). 6.46 (H, d. J 15.7, CHbCONH) 6.78 (H, s, CHO). 4.90 (1 H, d, J 12.7 ArCHaCHb), 4.26 (1 H, td, J 10.6, 2.7, OCHaCHb). 3.87 (1H, ddd. J 12.6. 3.5, 2.5, OCHaCHb). 3.71 (1H. d, J 12.7, ArCHaCHb). 2.85 (1H. ddd. d. J 14.1. 8.6, 2.2, NCHaCHb). 2.64 (1H. ddd, J 14.1, 5,1, 2.6. NCHaCHb). 2.50 (3H. s, NCJI3). 2-(5-methyl-1-phenyl-1,3,4,6-tetrahydro-5H-benz[1]-2,5-oxazocine-9-ethyl)carboxamide (12a) (Formula Removed) To a round bottom flask containing a solution of 2'-acryiamideHnefopam (130mo, 0.4mmol) in methanol (2mi) was added 20mg of 10% Pd onCHarooal under N2. On completion of addition, a bal100n of H2 was added and the reaction purgec; with H2. The reaction mixture was then left at RT for 24 houR5. Once the reaction was completed, the mixture was filtered through a plug of Celke and solvent evaporated. The crude reaction mixture was purified by column chromatography eluted with 10% MeOH:DCM (2 drops of TEA per 200ml). The compound was isolated as a yellow oil. (BOmg, 62%). 1H nmr (250MHz. MeOD); 7.30-7.04 (7H. m. ChU), 6.91 (1H, s, CtU), 5.75 (H, s. CaO). 4.87 (1H, d. J13.6 ArCHaCHb), 4.16 (1H. td, J 9, 3, OCHaCHb). 3.83 (1H. ddd. J 12.6. 4.7, 2.4. OCHaCHb ). 3.62 (1H, d. J 12.5. ArCHaCHb). 2.83 (3H, m. d, NCtl.CHb, CH3), 2.69-2.38 (6H, m, NCHaCHb.NCHaCHb). 2-(5-methyl-1-phenyI-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazoclne-8' ethyi)carboxamide (12b) (Formula Removed) To a round bottom flask containing a solution of 3'-acrylamide-nefopam (96mg, O.Smmol) in methanol (3ml) was added 15mg of 10% Pd on CHarcoal under N2- On completion of addition, a bal100n of H2 was added and the reaction purged with H2. The reaction mixture was then left at RT for 24 houR5. Once the reaction was completed, the mixture was filtered through a plug of Celite and solvent evaporated. The crude reaction mixture was purified by column chromatography eluted with 10% MeOH.DCM (2 drops of TEA per 200ml). The compound was isolated as a yellow oil, (96mg, 100%). 1H nmr (250MHz, MeOD); 7.34-7.23 (5H, m, CHar), 7.07-7.02 (2H, m, -CHar),,6,92 (.1H. d, J B,. CHar).. 5,77.(H, s, CHO),.5.59A2H, bR5. NH2). 4,7(1H, d, J 12.8, ArCHaCHb), 4.16 (1H, ddd, J 12.6, 8.3, 2.8 OCtUCHb), 3.85 (1H, ddd, J 12.5. 5.8, 2.1, OCH.Ciib ), 3.65 (1H, d, J 12.5, ArCH.Chlb). 2.93 (2H. t. J 7.3, CH2). 2.83 (1H. ddd. 14, 7.9. 2.2, NC1-6CHb), 2.60 (H, ddd, J 14. 5.8. 2.45, NCHaCJdb), 2.57-2.48 (5H, m. CH2.NCHb.CH2). 5-methyl-1-phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazoclne-9-methylamlne (13a) (Formula Removed) A dry round bottom flask was CHarged with 8a (70mg, 0.18mmol), arKi TFA (1 ml). The reaction was stirred at RT under N2 for 1 hour. Once the reaction was completed, the solution was diluted with water (10ml) and the mixture extracted three times with ether (1 Oml). The aqueous portion was base washed with 1M NaOH until PH 14, the aqueous phase was then extracted three times with DCM (20ml). The organic phase was then dried over MgSo4 and solvent removed under reduced pressure. The compound was obtained as a yellow oil (25mg, 60% yield). 1H nmr (250MHz. CDCI3); 7.31-7.18 (7H. m, GH.r). 6.92 (H, s. CtU), 5.76 (H. s, CtlO). 4.62 (1H. d, J 13. ArCHaCHb). 4.19 (1H, td. J 8, 3. OCtUCHb). 3.69-3.65 (4H,m, OCHaChib, ArCHaCHt, CHa), 2.82 (1H. ddd. d, J 14, 8, 2 NCH«CHb), 2.60 (1H. ddd, J 14, 5, 2, NCHaCHb), 2.46 (3H, s, NCHa). 1-25 (2H. bR5. NH2). 5-methyl-1-phenyl-1,3,4,6-tetrahydro-5H-benztf]-2,5-oxazocine-8-methylamine (13b) (Formula Removed) A dry round bottom flask was CHarged with 8b (60mg, 0.16mmol), and TFA (1ml). The reaction was stirred at RT under N2 for 1hour. Once the reaction was completed, the solution was diluted with water (10ml) and the mixture extracted three times with ether (10ml). The aqueous portion was base washed with 1M NaOH until PH 14; the aqueous phase was then extracted three times with DCM (20ml). The organic phase was then dried over MgSo4 and solvent removed under reduced pressure. The compound was obtained as yellow oil. (26mg, 60% yield). 1H nmr (250MHz, CDCIa); 7.31-7.10 (8H, m, CHar), 6.97 (1H. d, J7.6 CHar), 5.79 (H, s, CJdO). 4.91 (1H, d, J 12.5, ArCHaCHb), 4.17 (1H, ddd, J 12.8. 8.3,2.8, OCHaCHb). 4.0 (2H. brs, NH2). 3.89-3.83 (3H. m. OCHaCHb, CH2), 3.67 1H. d. J 12.5, ArCH,Cii,), 2.85 (1H, ddd, d, J 14. 8, 2 NCHaCHb). 2.65 (1H, ddd, J 14, 51, 2.4, NCH.Chlb), 2.49 (3H. s, NCJi), 2-(4-Methoxy)benzoyl-4-bromobenzoic acid and 2-(4-methoxy)benzoyl-5- bromobenzoic acid (14) (Formula Removed) To a flask containing 4-bromophthalic anhydride (1) (25.66g, O.Hmol) was added finely crushed aluminium chloride (30.13g, 0.23mol), The solid mixture was further crushed and stirred using a spatula. To this mixture was added anisole (85.53g, 86ml, 0.79mol) which initiated the production of HCJ gas. Once gas evolution ceased the reaction was heated at 80°C for 1.6 houR5. The hot reaction mixture was poured Into a solution of water: cone! hydrochloride acid (9:1, 600mL) and the aqueous layer extracted with ether (2 x 160mL). The organic layer was washed with water and then brine before being dried over magnesium sulphate, filtered and evaporated under reduced pressure to furnish the crude product. Overnight recrystallisation from a mixture of ether (2C)0mi) and hexane (400ml) yielded 14, after filtration, a white solid as a mixture of regio isomeR5. Yield 22.77g, 60%. 1H nmr (250MHz, CDCI3); 9.28 (2H, bR5. 2xC02il). 8.19 (1H. d, J 1.8. CHar). 7.92 (1H. d, J 8.4, CHar), 7.78 (1H, d. J 1.8. CHar). 7.74 (1H. d, J1.8. CHar), 7.69 (2H. d, J 2.0, CHar). 7.65 (2H, d, J1.8, CHar). 7.48 (1H, d, J 1.8.CHar), 7.22 (1H, d, J8.1 CHar). 6.91 (2H, d, J2.5. ), 6,88 (2H, d. J2.5.CHar), 3.86(6H, s, 2XCH3). /V-(2-hydroxyethyl)-N-methyl-2-(4-methoxy)benzoyl-4-bromobenzannide (15a) and N-(2-hydroxyethyl)-/V-methyl- 2-(4-methoxy)benzoyl-5- bromobanzamlde (15b) (Formula Removed) A solution of 2M oxalyl chloride (6.52mL, 74.73mmol, 1.1 equiv.) in dichloromethane was added dropwise to a suspension of the mixture of isomers 14 (22.77g, 67.94mmol) in dichloromethane (115mL) and catalytic N,N-dimethylformamide (5 drops) at room temperature under a nitrogen atmosphere. Gas evolution was rapid and as the reaction proceeded the solid dissolved in the dichloromethane. After 2.5 hours the solvent was removed under reduced pressure and the resulting solid co-evaporated with dichloromethane (2 x 100mL) to remove traces of excess oxalyl chloride. The crude acid chloride was dissolved in dichloromethane (115mL) and added dropwise to a solution of N-methylaminoethanol (6.0mL, 74.73mmol, 1.1 equiv.) and triethylamine. (10.42mL, 74.73mmol, 1.1 equlv) in dichloromethane (115mL) cooled to 0°C in an ice bath. The resulting solution was stirred at room temperature for 3 liours, quenched with saturated aqueous sodium dicart>onate (100mL) and separated. The aqueous layer was extracted with dichloromethane (100mL) and the combined organic fractions washed with brine (50mL), dried over magnesium sulfate and filtered. The solvent was removed under reduced pressure and the crude product purified by column chromatography, eluting with ethyl acetate : hexane (4:1), followed by ethyl acetate (100%) as product elutsd. Compound 15a was furnished as a yellow semi solid. Yield 5.00g, 19%. The product exists are a mixture of rotomers in a 3:2 ratio. 1H nmr (250MHz. CDCh); 7.81 (2H, d, J 7.5, CHar). 7.71-7.53 (2H. m, CHar). 7.31 (1H. m, CH,0, 6 95 (2H. d. J 7.6, CHar). 3.88 (3H, s, CC Hb). 3.80 (2H, t, J 5.1. CHbOH). 3.72 (1H, m Otl), 3.57 (2H. t. J 4.9, NCHa), 3.06 (1.2H, s. NCHb) 2.96 (1.8H. s. NCHl3). Compound 15b was furnished as a red semi solid. Yield 5.00g, 19%. The products exist as a mixture of rotomers in a 3:2 ratio. 1H nmr (250MHz, CDCI3); 7.77 (2H, dd. J9.0, 2.4. CHar), 7.59-7.53 (2H, m. Cli.r). 7.42-7.31 (1H, m, CHar), 6.91 (2H. dd, J 9.0, 2.4, CHar), 3.85 (3H. s. OCida). 3.79 (2H. t. JS.1, PrbOH), 3.69 (i ;H. bfs Oil). 3.56 (2H, t, J 5.1, NCli). 3.03 (1.2H. s, NCHb) 2.95 (1.8H. s. NCida)-/V-(2-hydroxyethyl)-/V-methyl-4-bromo-2-[1-hydroxy-1-(4-methoxyphenyi)] methylbenzylamine (16a) (Formula Removed) Amide 15a (1.56g, 3.99mmol) \Nas dissolved in tetrahydrbfuran (10mL) and cooled to 0°C in an ice bath. A 2M solution of borane dimethylsulfide complex (8.78mL, 17.55mmol, 4.4 equlv.) was added dropwise and the resulting solution stirred at room temperature for 17 houR5. The reaction was carefully quenched with 2M hydrochloric acid solution (5mL) and the resulting solution stirred at room temperature for 2 houR5. Tetrahydrofuran was removed under reduced pressure and remaining solution diluted with water (10mL) and extracted with diethyl ether (2 x 50mL). The aqueous layer vk^s bastfied with 3.75M sodium hydroxide solution and extracted with ethyl acetate (2 x 50mL). The combined ethyl acetate extracts were dried over magnesium sulfate, filtered and evaporated under reduced pressure to furnish the desired product 16a as a white foam. Yield 754mg, 50%. 1H nmr (250MHz, CDCIs); 7.39-7.24 (4H, m, ChU). 7.07-6.98 (1H, m. CHar). 6.8S-6.79 (2H. m, CHar). 5.77 (1H, s. CHOH). 3.80 (3H, s. OCJds), 3.67 (2H. m, OCii), 3.41 (1H. d, J, 12.4, ArChUHbN). 3.28 (1H. d, J. 12.7, ArCH,iibN), 2.57-2.50 (2H. m, NCtb), 2.17 (3H. s. NCHs). Af-(2-hydroxyethyl)-N-methyI-5-bromo-2-[1 -hydroxy-1 -(4-methoxyphenyl)] methylbenzylamlne (16b) (Formula Removed) Amide 15b (1.54g, 3.93mmol) was dissolved in tetrahydrofuran (10mL) and cooled to 0°C in an ice bath. A 2M solution of borane dimethylsulfide complex (8:60mL, 17.28mmol, 4.4 equiv.) was added dropwise and the resuiung solution stirred at room temperature for 17 houR5. The reaction was carefully quenched with 2M hydrochloric acid solution (SmL) and the resulting solution stirred at room temperature for 2 houR5. Tetrahydrofuran was removed under reduced pressure and remaining solution diluted with water (lOmL) and extracted with diethyl ether (2 x 50mL). The aqueous layer was basified with 3.76M sodium hydroxide solution and extracted with ethyl acetate (2 x 50mL). The combined ethyl acetate extracts were dried over magnesium sulfate, filtered and evaporated under reduced pressure to furnish the desired product 16b as a white foam. Yield 606mg, 40%. 1H nmr (250MHz. CDCI3): 7.45-7.33 (2H. m. CHar), 7.24 (2H, d, J 8.4. CHarr). 7.03-6.95 (1H. m, CHar). 6.86 (2H, d. J 8.7, CHar), 5.79 (1H. s. CMOH), 3.79 (3H, s. OCJda). 3.65 (2H, m, OCtb), 3.41 (1H, d, J, 12.5. ArCHarHbN). 3.28 (1H. d, J, 12.5. ArCHaCHbN). 2.56-2.50 (Formula Removed) Diol 16a (764mg, 1.99mmol) was dissolved in toluene (lOmL) and para-toluenesulfonic acid monohydrate (568mg, 2.98mmol, 1.5equiv.) added. The toluene was removed under reduced pressure and the resulting oil heated at 105*0 for 2 houR5. On cooling the oil was suspended in water (10mL) and basifjed with 3.76M sodium f rydroxide sol.„ ion. The aqueous layer was extracted with ethyl acetate (2 x 25mL), dried over magnesium sulfate, filtered and evaporated under reduced pressure to furnish the crude product which was purified by chromatography eluting with 10% methar-ol in ethyl acetate. Fractions containing product were combined and evaporated under reduced pressure to furnish 17a. Yield 340mg, 47%. 1H nmr (250MHz, CDCI3); 7.34 (1H. dd, J 8.1. 1.8, CHar). 7.16 (2H, d, J 8.7, CHar), 7.12-7.06 (2H, m, CHar). 6.85 (2H. d. J 8.6, CHiar), 5.66 (1H, s. CHOH), 4.83 (1H, d, J12.8, ArCHaHb), 4.15(1H. m, OCHaHb), 3.83 (1H. OCHaHb), 3.78 (3H, s, OCH3), 3.60 (1H, d, J 12.8. ArCHaCHb). 2.77 (1H, m NCHaCHb), 2.59 (1K. ddd, J 2.6, 5.5. 14.2, NCHaCHb), 2.43 (3H, s, CHj). 8-Bromo-5-methyl-1-{4-niethoxy)phenyl-1.3.4,6-tetrahydro-5H-benz[1]-2,5-oxazocine (17b) (Formula Removed) Diol 16b (200mg. 0.53mmol) was dissolved in toluene (5mL) and para-toluenesulfonlc acid monohydrate (150mg, 0.79mmol, I.Sequiv.) ackted. The toluene was removed under reduced pressure and the resulting oil heated at 105°C for 2 houR5. On cooling the oil was suspended in water (lOmL) and basified with 3.75M sodium hydroxide solution. The aqueous layer was extracted with ethyl acetate (2 x 25mL), dried over magnesium sulfate, filtered and evaporated under reduced pressure to furnish the crude product which was purified by chromatography eluting with 10% meti-ianol in ethyl acetate. Fractions containing product were combined and evaporated under reduced pressure to furnish 17b as a clear oil. Yield 127mg, 67%. 1H nmr (250MHz. CDCI3); 7.36 (1H, d. J 1.5. CHar). 7.29 (1H, dd, J 8.4. 18, CHar), /.15 (2H, d. J8.7, CH,r), 6.85 (1H. m. CH,r), 6.83 (2H, d. J8.6, CMar). 5.68(1H. s, CtdOH). 4.81 (1H. d, J12.8,ArCHaCHb), 4.13 (1H, m, OCHaCHb), 3.83 (1H. OCHaCHb), 3.76 (3H, s, OCH3), 3.58 (1H, d, J 12.8, ArCHaidb). 2.77 (1H, m NCHaCHb). 2.61 (1H, ddd, J2.5. 5.7, 14.1. NCHaCHb), 2.45 (3H. s. CHa). 2-(3-Methoxy)benzoyl-4-bromobenzoic acid and 2-(3-methoxy)benzoyl-5-bromobenzoic acid (18) (Formula Removed) Magnesium (2.45g, 0.1 mol) was suspended in anhydrous ether bromophthalic anhydride (1) (25g. 0.1 mol) in toluene (150ml) and ether (30mi) under a nitrogen atmosphere. The subsequent reflux was maintained for 24 hours, cooled and quenched with saturated aqueous NH4CL Thw aqueous layer was extracted with diethyl ether (3 x 200ml). dried over MgSo4, filtered and concentrated under reduced pressure to give the desired mixture of regioisomers (30.1g, 82% yield). 1H nmr (250MHz. CDsOD); 8.19 (H, s. CHar). 7,92 (H, d, CHar). 7.74 (2H, dd, J23.5, 8.7, CHar), 7.51 (H. s, CHar), 7.36-7.09 (9H, m, CHar). 6.95-6.85 (H, m, CHarr), 6.52-6.40 (H, m. CHar), 2.35 (6H, s, OCHar). N-(2-hydroxyethyl)-N-methyl- 2-(3-methoxy)benzoyl-4-bromobenzannlda (19a) and N-(2-hydroxyethyl)-N-rnethyl- 2-(3-methoxy)benzoyl-5-bromobenzamfde (19b) (Formula Removed) A solution of 2M oxalyl chloride (8.66mL, 0.1 mol) in dichloromethant; was added dropwise to a suspension of the mixture of isomers 18 (30.Og, O.OSmol) in dichloromethane (200ml) and catalytic N,N-dimethylformamicle (1 drop) at room temperature under a nitrogen atmosphere. Gas evoiutlon was rapid and as the reaction proceeded the solid dissolved in the dichloromethane. After 2.5 hours the solvent was removed under reduced pressure and the resulting solid co-evaporated with dichloromethane to remove traces of excess oxaiyi chloride. The crude acid chloride was dissolved in dichloromethane (200mL) and added dropwise to a solution of /V-methylaminoethanol (6mL, 0.1 mol.) and triethyamine (14mL) in dichloromethane (200mL) cooled to 0°C in an ice bath. The resulting solution was stin'ed at room temperature overnight, quenched with saturated aqueous ammonium chloride and separated. The organic layer was washed with water (2 x 400mL), dried over magnesium sulfate and filtered. The solvent was removed under reduced pressure and the crude product purified by chromatography, elutlng with hexane : ethyl acetate. (1:1) to yield 19a (8.88g, 25% yield) and 19b (6.13g, 18/o yield) as v sccus oils. 19a: 1H nmr (250MHz, CDCI3); 7.61-7.56 (3H, m, ), 7.49-7.44 OH). N-(2-hydroxyethyl)-N-methyl-4-bromo-2-[1 -hydroxy-1 -(3-methoxyphenyl)] methylbenzylamine (20a) (Formula Removed) Amide 19a.(700mg, 1.78mmol) was dissolved in tetrahydrofuran (3mL) and cooled to 0°C in an ice bath. A 2M solution of borane dimethylsulfide complex (3.6mL, 7.12mmol, 4.4 equiv.) was added dropwise and the resulting solution stirred at room temperature for 17 houR5. The reaction was carefully quenched with IM hydrochloric acid solution and the resulting solution stirred overnight. Tetrahydrofuran was removed under reduced pressure and the remaining solution washed with diethyl ether until all by-products had been removed. The aqueous layer was baslfied with NaOH (2M) and extracted using ethyl acetate (30ml). After washing with NaOH (2x50ml) and water (50ml), the ethyl acetate was dried over MgSo4, filtered and concentrated under reduced pressure to furnish the desired product 20a as a viscous oil. Yield 400mg, 59%. 1H nmr (250MHz, CDCb); 7.37-7.31 (2H, m, CHar), 7.21 (1H, t. J 8.5, CHar). 7.05-6.98 (2H, m. CHar), 6.85-6.77 (2H, m. CHar). 5.75 (1H, s. CJiOH), 3.77 (3H, s. OCtb). 3.65-3.61 (2H. m, OCHb). 3.29 (2H. dd. J. 25.3.13.5, ArCHarHbN), 2.50 (2H. dd, J 10.9, 5.4. NChiz). 2.02 (3H. s, NCHb). N-(2-hyclroxyethy|)-N-methyl-5-bromo-2-[1-hydroxy-1-(4-methoxyphenyl)] methytbenzylamine (20b) (Formula Removed) Amide 19b (550mg, 1.40mmol) was dissolved in tetrahydrofuran (3mL) and cooled to 0°C in an ice bath. A 2M solution of borane dimethylsulfide complex (2.8mL, 5.60mmol, 4.4 equiv.) was added dropwise and the resulting solution stirred at room temperature for 17 houR5. The re3ction was carefully quenched with 1M hydrochloric acid solution and the resulting solution stirred overnight. Tetrahydrofuran was removed under reduced pressure and the remaining solution washed with diethyl ether until all by-products had been removed. The aqueous layer was baslfied with NaOH (2M) and extracted using ethyl acetate (30ml). After washing with NaOH (2x50ml) and water (50ml), the ethyl acetate was dried over MgSo4, filtered and concentrated under reduced pressure to furnish the desired product 20b as a viscous oil. Yield 300mg, 56%. 1H nmr (250MHz, CDCb); 7.40-7.35 (3H, m, CHar). 7.28-7.20 (2H, m. Chlar). 7.07 (1H, d, J 8.6. CHar), 5.80 (1 H, s. CHOH), 3.79 (3H, s. OCH3) 3.71- 3.66 (2H, m, OCH2). 3.36 (2H. dd, J, 19.6, 12.5, ArCH2N). 2.62-2.49 (2H. m. NCH2). 2.04 (3H. s, NCHar). 9-Bromo-5-methyl-1 -(3-methoxy)phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine (21a) (Formula Removed) Diol 20a (400mg, I.OSmmoi) was dissolved in toluene (2mL) and para-toluenesulfonic acid monohydrate (300mg, 1.58mmol. 1 .Sequiv.) added. The toluene was removed under reduced pressure and the resulting oil heated at 105°C for 4 houR5. On cooling the oil was suspended in water (100mL) and oasified with 3.76M sodium hydroxide solution. The aqueous iayer was extracted with ethyl acetate, dried over magnesium sulfate, filtered and evaporated under reduced pressure to furnish the crude product. Purification by column chorography (10% methanol in ethyl acetate) furnished 21a as yellow solid. Yield 71 mg. 19%. 1H nmr (250MH2. CDCIa); 7.39-7.05 (5H, m, CHar), 6.84-79 (3H, m, CHarr). 5.66 (1H. s, CJD, 4.78 (1H. d, J 13.8, ArC2-6Hb). 4.22-4,13 (1H, m, OCHaHb), 3.84-3.83 (1H, m. OCHaCHb), 3.77 (3H, s, OCH3). 3.64 (1H, d, J 13.7, ArCHaCHb), 2.82-2.74 (1H, m NCHJdb). 2.64-2.67 (1H, m, CHaCHb), 2.42 (3H, s. CHs). 8-Bromo-5-methyl-1-(3-methoxy)phenyl-1,3,4,o-tetrahydro-5H-benz[f]-2,5-oxazoclne (21b) (Formula Removed) Diol 20b (300mg, 0.79mmol) was dissolved in toluene (2mL) and para-toluenesulfonic acid monohydrate (228mg. 1.2mmol, LSequiv.) added. The toluene was removed under reduced pressure and the resulting oil heated at 105°C for 4 houR5. On cooling the oil was dissolved in 3.75M sodium hydroxide solution and extracted with ethyl acetate, dried over magnesium sulfate, filtered and evaporated under reduced pressure to furnish 21b as a brown oil. Yield 76mg, 26%. No further purification was performed. 1H nmr (250MHz. CDCl3); 7.37-719 (3H, m, CHar). 6.89-6.78 (4H, m. CHar), 5.70( (1H, s, CM), 4.75 (1H. d, J 14. ArCHaCHb), 4.20-4.10 (1H, m, OCHarHb). 3.86-3.77 (4H, m, ArCHaCHb), OCil3). 3.60 (1H, d, J14. ArCHaCHb). 2.80(1H, ddd. J2.1. 8.5, 15.3, NCHarHb). 2.62 (1H. ddd. J 2.7, 6.4, 15.3, NCHaCHb 2.44 (3H, s, CHb). 9-Cyano-5-inethyl-1-(3-methoxy)phenyl-1,3,4,6-tetrahydro-5H-benzEf]-2,5-oxazocine (22a) (Formula Removed) Bromo-nefopam analogue 21a (503mg, 1.39mmol), Zn 2.09mmol), and Pd(PPh3)4 (241 mg, 0.21 mmol), were dissolved in degassed anhydrous DMF (10mL) under a Ns atmosphere. The mixture was refluxed under N2 for 24 houR5. The mixture was allowed to coot to room temperatuR6, fillered through celite and washed through with DCM (50ml). The filtrate was then quenched with water (10ml) and solvent extracted. The organic extract was dried over MgSOii, filtered and solvent removed under reduced pressure. The crude product was purified by dry flash chromatography eluting with 5%-15% MeOH in DCM. Fractions containing the product were combined and evaporated under reduced pressure to produce 22a as pale brown oil. Yield 143mg, 33%. 1H nmr (250MHz. CDCI3); 7.51 (1H, dd, J 1.4, 7.6, CHar). 7.32-7.23(4H, m, CHar), 6.84-6.81 (3H, m. CH„). 5.76 (1H, s, CHO), 4.85 (1 H, d. J 12.8, ArCHaHb), 4.18-4.15 (1H, m, OCHaHb), 3.86-3.81 (1H. m, OCHabb). 3.79 (3H, s,OCIHa), 3.71 (1H. d, J 12.8, ArCHaCHb), 2.78 (1H, ddd, J2.3. 8.2, 14.3, NCJH.Hb),2.63(1H.ddd. J 2.8, 5.6, 14.3, NCHaCHb). 2.44 (3H, s, NCHar). 8-Cyano-5-methyl-1-(3-methoxy)phenyl-1,3t4,6-tetrahydro-5H-beriz[f]-2,5-oxazocine (22b) (Formula Removed) Bromo-nefopam analogue 21b (223mQ, 0.62mmol). Zn(CN)2 (109mo, 0.93mmol), and Pd(PPh3)4 (107mg, 0.09mmol), were dissolved in degassed anhydrous DMF (6mL) under a Nj atmosphere. The mixture was refluxed under Nafor 24 houR5. The mixture was allowed to cool to room temperatuR6, filtered through celite and washed through with DCM (50ml). The filtrate was then quenched with water (10ml) and solvent extracted. The organic extract was dried over MgSo4. filtered and solvent removed under reduced pressure. The crude product was purified by dry flash chromatography elutlng with 5%-15% MeOH in DCM. Fractions containing the product were combined and evaporated under reduced pressure to produce 22b as pate brown solid. Yield 94mg, 50%. 1H nmr (250MHz. CDCI3): 7.50 (1H. s. CM.,), 7.46 (1H, dd. J 1.7. 8.1, CHar). 7.26-7.21 (1fl. m, CH„). 7.12 (1H, d. J 7.9, Cjdar). 6.83-6.80 (3H. m, t:.Har), 5.74 (1H. s, CHO), 4.94 (1H, d, J 13.0, ArCHarHb), 4.28-4.19 (1H, m, OCHarHb), 3.87-3.79 (1H, m. OCH1Hb), 3.77 (3H, s, OCida), 3.65 (1H, d, J 13.0, ArCHaCHb), 2.74 (1H. ddd, J 2.3. 8.3. 14.3, NCHaHb), 2.63 (1H, ddd, J 3.0. 5.4, 14.3, NCHaCHbb), 2.45 (3H, s. NCH3). 9-Methoxy-5-methyI-1-phenyl-1,3,4,6-tetrahydro-5H-benz[f]-^5-oxazocine (23a) (Formula Removed) Ethyl acetate (0.1 ml) was added to a stirred 5M NaOMe methanol solution (1ml) under an N2 atmosphere at room temperature. Bromo-nefopam analogue 5a (210mg, 0.58mmol) in MeOH (1 ml) was then added followed by CuBr (17mg. 0.12mmol). The mixture was stirred at 76°0 overnight, cooled to room temperature and quenched using water (5ml). The organic layer was separated and the aqueous was washed with ethyl acetate (2x10ml). The combined organics were dried over MgSO4. filtered and concentrated under reduced pressure. The crude product was purified by dry flash chromatography eluting with 10% MeOH in DCM. Fractions containing the prodvict were combined and evaporated under reduced pressure to produce 23a as an orange oil. Yield 131mg, 73%. 1H nmr (250MHz, CDCI3): 7.31-7.24 (5H, m. CHar). 7.16 (1H, d. J 8.4, CHarr), 6.77 (1H. dd, J2.7, 8.3, CHar), 6.53 (1H. d, J2.6, CHar). 5.72 (1H. s, CHO), 4.74 (1H, d, J 12.8, ArCJiHb), 4.23-4.15 (1H, m. OCHaCHb), 3.86 (1H, ddd, J 2.3. 5.6, 12.6, OCHdib), 3.71 (3H, s. OCHb), 3.68 (1H, d. J 12.8. ArCH,tlb), 2.84 (1H. ddd. J 2.3, 8.5, 14.2, NCHaCHb), 2.62 (1H, ddd, J 2.7, 5.6, 14.3, NCHJib). 2.45 (3H. s, NCids). 8-Methoxy-5-methyl-1-phenyM,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine (23b) (Formula Removed) Ethyl acetate (0.1ml) was added to a stirred 5M NaOMe methanol solution (1ml) under an N2 atmosphere at room temperature. Bromo-nefopam analogue 5b (215mg, 0.60mmol) in MeOH (1 ml) was then added followed by CuBr(17mg, 0.12mmol). The mixture was stirred at 75°C overnight, cooled to room temperature and quenched using water (5ml). The organic layer was separated and the aqueous was washed with ethyl acetate (2x10ml). The combined organics were dried over MgSo4, filtered and concentrated under reduced pressure. The crude product was purified by dry flash chromatography eluting with 10% MeOH in DCM. Fractions containing the product were combined and evaporated under reduced pressure to produce 23b as an orange oil. Yield. 161mg, 88%. 1H nmr (250MH2, CDCIa); 7.35-7.20 (5H. m. CHar), 6.89 (1H. d, J 8.3. CHarr), 6.76 (1H. s, CHar). 6.72 (1H, m. CHar). 5.80 (1H. s. CJdO), 4.64 (1H, d. J 12.8, ArCHarHb). 4.11 (1H. ddd, J2.5, 8.0, 12.7. OCid,Hb). 3.87.(1H, ddd, J2.2, 6.0,12.7, OCHahU), 3.80 (3H, s, OCHb). 3.70 (1H, d. J 12.8, ArCHJi,). 2.87 (1H. ddd. J 2.0. 8 0. 14.2, NCJdaHb), 2.66 (1H. ddd, J 2.4. 6.1, 14.2, NCHaCHb). 2.48 (3H. s, NCHi,). 9-Methoxy-5-methyl-1 -(3-methoxy)phenyI-1,3,4,6-totrahyclro-6H-benzIfl-2,6-oxazocine (24a) (Formula Removed) Ethyl acetate (0.1 ml) was added to a stirred 6M NaOMe methanol solution (1ml) under an N2 atmosphere at room temperature. Bromo-nefopam analogue 21a(173mg, 0.48mmol) in MeOH (1ml) was then added followed by CuBr (14mg, O.IOmmot). The mixture was stirred at 75*'C overnight, cooled to room temperature and quenched using water evaporated under reduced pressure to produce 24a as an orange ail. Yield 34mg, 22%. 1H nmr (250MHz, CDCI3); 7.20 (1H, d. J 8.2. CHar). 7.15 (1H. s, Cti«), 6.87-6.84 (3H, m. CHar), 6.77 (1H. dd. j 2.6, 8.3, CHar), 6.54 (1H. d. J2.6. CJiO, 5.68 (1H. s, CHO), 4.76 (1H. d, J 12,8, ArCHaCHb). 4.24-4.16 (1H. m. OCHarHb). 3.85 (1H, ddd, J2.4, 5.3,12.7, OCHJi), 3.76 (3H, s, OCHar). 3.71 (1H. d. J 12.8, ArCHahlb), 3.70 (3H, s, OCida). 2.85 (1H, ddd, J 2.1. 8.7. 14.1, NCHarHb), 2.64 (1H, ddd, J 2.7, 6.3. 14.3, NCHaCHb). 2.47 (3H. s, NCtb). 8-Methoxy-5-methyl-1-(3-methoxy}phenyI-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine (24b) (Formula Removed) Ethyl acetate (0.1ml) was added to a stirred 5M NaOMe methanol solution (1ml) under an N2 atmosphere at room temperature. Bromo-nefopam analogue 21 b (168mg, 0.47mmol) in MeOH (1 ml) was then added followed by CuBr (13mg, 0.09mmol). The mixture was stirred at 75'C overnight, cooled to room temperature and quenched using water (5ml). The organic layer was separated and the aqueous was washed with ethyl acetate (2x10ml). The combined organics were diried over MgSO4, filtered and concentrated under reduced pressure. The crude product was purified by dry flash chromatography eluting with 10% MeOH in DCM. Fractions containing the product were combined and evaporated under reduced pressure to produce 24b as an orange oil. Yield 77mg. 50%. 1H nmr (250MHz, CDCIa); 7.22 (IN. t. J8.2, CHar),6.92-6.71 (6H,m, CH,,), 5,78 (1H, s, CHO), 4.60 (1H, d, J 12.7, ArCHaCHb). 4.09 (1H, ddd, J 2.4, 7.9. 12.7, OCH«Hb), 3.90-3.82 (1H, m, OCHaCHb). 3.80 (3H, s, OCH3), 3.77 (3H, s, OCHa), 3.70 (1H. d, J12.8. ArCHaCHb). 2.85 (1H, ddd, J 1.9, 7.9, 14.2, NCHaCHb). 2.65(1 H. ddd, J 2.5, 6.1, 14.2. NCHaCHb), 2.47 (3H, s. NCH3). Cyclopropylboronic Acid (25) (Formula Removed) To a stirred solution of trimethyiborate (1.69g, 1.81 ml, 16.25mmol) in THF (7ml) at -78**C under a Na atmosphere was added, by drop wise addition, cyclopropylmagnesium bromide (0.5M in THF, 25ml, 12.5mmol). A white precipitate fonned. After 1 hr the reaction was warmed to room temperature and stirred overnight. The reaction was quenched with HCI aq. 1H nmr (250MHz, CDCb); 0.56-0.50 (2H. m.Ch2). 0.42-0.40 (2H, m. CHb). -0.08-0.20 (IH.m, CM). 9-Cyclopropy|.5-methyi-1 -phenyl-1,3,4,6-tetrahydro-6H-ben2[f]-2,6-oxazocine (26a) (Formula Removed) To a stirred solution of bromo-nefopam analogue 5a (11 mg, 0.64mmol), cyclopropyl boronic acid (71 mg, 0.83mniol), potassium phosphate (472mg, 2.22mmol) and tricyclohexyiphosphine (18mg. O.OSmmol) in toluene (5ml) and water (250 pi) under a N2 atmosphere was added palladium acetate (7mg, O.OSmmol). The mixture was heated to 100°C for 3hrs and then cooled to room temperature. Water (10ml) was added and the mixture extracted with ethyl acetate (2x15ml). The combined organic extracts were washed with brine (1 0ml), dried over MgSO4 and concentrated under reduced pressure to give a yellow oil. The crude product was purified by dry flash chromatography eluting with 15% MeOH in DCM. Fractions containing the product were combined and evaporated under" reduced pressure to produce 26a as a yellow oil. Yield 145mg, 78%. 1H nmr (250MHz, CDCb); 7.32-7.24 (5H. m. CHar). 7.11 (1H, d. J 7.8. CHar), 6.87 (1H, dd. J1.8, 7.8, CHar). 6.73 (1H. d. J1.5. CHar). 6.74 (1H, s, ChlO). 4.75 (iH, d, J 12.8. ArCJd-Hb), 4.17 (1H, ddd, J2.8, 8.3,12.4. OCHarHb), 3.85 (1H. ddd, J2.3, 6.0, 12.5, OCHJi,), 3.63 (1H. d. J 12.8, ArCHJi,), 2.81 (1H. ddd. J 2.2, 8.2, 14.1, NCHarHb). 2.61 (1H, ddd, J 2.7, 5.9. 14.2, NCHaCHb). 2.44 (3H. s, NCJi), 1.77 (IH. m. CM). 0.91-0.86 (2H, m. Cli), 0.61-0.57 (2H. m, Cji). 8-Cyclopropyl-5-methyl-1-phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine (26b) (Formula Removed) To a stirred solution of bromo-nefopam analogue 5b (178mg, 0.54mmoi), cyclopropyi boronic acid (60mg, 0.70mmol), potassium phosphate 1.88mmol) and tricyclohexylphosphlne (15mg, 0.05mmol) in toiuer>e (4ml) and water (200 \i\) under a N2 atmosphere was added palladium acetate 0.03mmoJ). The mixture was heated to 100°C for 3hrs and then cooled to room temperature. Water (10miJ was added and the mixture extracted with ethyl acetate (2x15ml). The combined organic extracts were washed with brine (10ml). dried over MgSo4 and concentrated under reduced pressure to give a yellow oil. The crude product was purified by dry flash chromatography eluting with 15% MeOH in DCM. Fractions containing the product were combined and evaporated under reduced pressure to produce 26b as a yellow oil. Yield 132mg, 84%. 1H nmr (250MHz, CDCIa); 7.31-7.23 (5H, m. CH,r). 6.94 (IH. s. CHar). 6.86 (2H, d. J1.0. CHar). 5.78 (1H. s, CjHO), 4.70 (1H, d, J 12.5, ArCHaHb). 4.15 (IH. ddd, v/2.6, 8.2. 12.6, OCHaCHb). 3.86 (1H, ddd, J 2.1. 6.0, 12.7. QCHaCHb), 3.66 (1H. d. J 12.7. ArCHaCHbb). 2.85(1 H. ddd, J2.1, 8.2, 14.2, NCHaHb), 2.63(1 H, ddd. J 2.6. 6.0, 14.2. NCH«Hb). 2.48 (3H. s. NCHs). 1 -86 (1H, m, CM), 0.96-0.90 {2H, m, CH2). 0.72-0.66 (2H. m. Ch2). N-(Acetyl)-5-methyl-1-phenyI-1,3,4,6-tetrahydro-5H43enz[f]-2,5-oxazoclno-9-methylamine (27a) (Formula Removed) NaBH4 (129mg, 3.41 mmol) was cautiously added to a solution of NiCIa (126mg, 0.97mmol), acetic anhydride (0.1ml, 0.97mmol) and bromo-nefopam analogue 6a (134mg, 0.49mmol) in MeOH (8mO at room temperature under a N2 atmosphere. Once the vigorous reaction had subsided the mixture was left to stir at room temperature overnight. Methanol was removed under reduced pressure and the precipitate partially dissolved in EtOAc and NaHCOa (aq.). After filtration the green solid was repeatedly washed with EtOAc and NaHCOs (aq.). The organic filtrate was separated from the aqueous which was subsequently extracted with more EtOAc (3x10ml). The combined organic fractions were dried over MgSo4. filtered and concentrated under reduced pressure. The crude product was purified by dry flash chromatography eluting with 20% MeOH in DCM. Fractions containing the product were combined and evaporated under reduced pressure to produce 27a as an orange oil. Yield 6mg, 23%. 1H nmr (250MHz, CDCI3); 7.33-7.10 (7H, m. CHar). 6.87 (1H, s, CHar). 5.91 (IN, brs, NH), 5.73 (IN. s, CHO). 4.80 (IN, d, J 12.7, ArCH1Hb), 4.29 (1H, d. J 2.9. NHCHaCHb), 4.27 (1H, d. J 2.9. NHCHaCHb). 4.17 (1H, m, OCHaCHb). 3.82 (1H, ddd. J2.1, 5.6, 12.6, OCHaCHb), 3.65 (1H. d. J 12.7. ArCHaCHb).2.78(1H. ddd, J2.1. 8.4, 14.1. NCHaCHb). 2.59 (1H. ddd, J2.5, 5.6, 14.1. NCHaCHb), 2.43 (3H. s. NCH3), 1.93 (3H. s, CHaCO). N-(Acetyl)-6-methyl-1-phenyI-1,3,4,6-tetrahydro-6H-benz[f]-2,5-oxa20cine-8-methylamine (27b) (Formula Removed) NaBH4 (148mg, 3.92mmol) was cautiously added to a solution of NICb (145mg, 1.12mmol), acetic anhydride (0.11ml, 1.12mmol) andbromo-nefopam analogue 6b (154mg, 0.56mmol) in MeOH (8ml) at room temperature under a N2 atmosphere. Once the vigorous reaction had subsided the mixture was left to stir at room temperature overnight. Methanol was removed under reduced pressure and the precipitate partially dissolved in EtOAc and NaHCOs (aq.). After filtration the green solid was repeatedly washed with EtOAc and NaHCOs (aq.). The organic filtrate was separated from the aqueous which was subsequently extracted with more EtOAc (3x10ml). The combined organic fractions were dried over MgSo4, filtered and concentrated under reduced pressure. The crude product was purified by dry flash chromatography eiuting with 10-15% MeOH in DCM. Fractions containing the product were combined and evaporated under reduced pressure to produce 27b as an orange oil. Yield 83mg, 46%. 1H nmr (250MHz. CDCI3); 7.30-7.23 (5H, m, CHar). 7.14(1 H, s, Ctl,,). 7.11 (1H. d. J 8.1. CHarr). 6.97 (1H, d. J 7.8, CHar), 5.83 (1H, brs, NtD. 6.77 (1H, s, CH[0), 4.75 (1H, d, J 12.5, ArCHaCHb), 4.39 (2H, d. J5.7. NHCidU). 4.21-4.16 (1H. m, OCid.Hb). 3.33 (IN, ddd. J 2.1, 6.2. 12.6, OCHaCHb). 3 G4 (1H, d, J 12.7. ArCHaCHb), 2.84 {1H. ddd. J 2.1. 7.9, 14.2. NCHaCHb). 2.62 (1H, ddd, J 2.6. 6.1, 14.2. NCHaCHb), 2.49 (3H, s, NCMa), 2.00 (3H, s, CIHaGO). N-(MethyIsuIphonyl)-5-methyI-1-phenyl-1,3,4,6-tetrahydro-5H-benz[f|-2,5- oxazocine-9-methylamine (28b) (Formula Removed) NaBH4 (193mg, 5.11mmol) was cautiously added to a solution of NiCb (188mg, 1.45mmol), methanesulfonyl chloride (0.17ml, 2.19mmol) and bromo-nefopam analogue 6b (200mg, 0.73mmol) in MeOH (8ml) at room temperature under a N2 atmosphere. Once the vigorous reaction had subsided the mixture was left to stir at room temperature overnight. Methanol was removed under reduced pressure and the precipitate partially dissolved in EtOAc and NaHCOa (aq.). After filtration the green solid was repeatedly washed with EtOAc and NaHCOa (aq.). The organic filtrate was separated from the aqueous which was subsequently extracted with more EtOAc (3x10ml), The combined organic fractions were dried over MgSo4, filtered and concentrated under reduced pressure. The crude product was purified by dry flash chromatography eluting with 15-20% MeOH in DCM. Fractions containing the product were combined and evaporated under reduced pressure to produce 28b as a white solid. Yield 54mg. 21%. 1H nmr (250MHz. CDCl3); 7.95 (1H, s. CHar), 7.77 (1H, dd. J 1.5. 8.1, CHarr). 7.39 (1H, d. J8.2, CHar). 7.33-7.24 (5H, m, CHar). 6.00 (1H. s. Cfcl, 5.99 (1H. d, J 12.7. ArCHaCHb). 4.64 (1H, m, OCHaCHb), 4.48 (1H. d, J 12.8. ArCHiU), 4.15 (1H, m, OCHaCHb). 3.47 (3H, s, CMsSOz). 3.44 (1H. m, NCHaCHb), 3.3l (1H. m. NCHJi). 3.08 (2H, s, NHCh2), 2.70 (3H, s. NCJda). 9-Cyclopropyl-5-methyl-1 -(3-fnethoxy)phenyl-1,3 AB-tetrahydro-SH-benztQ-2,5oxazocine (29a) (Formula Removed) To a stirred solution of bromo-nefopam analogue 21a (104mg, 0.29mmol), cyclopropyl boronic acid (32mg, 0.37mmol), potassium phosphate (214mg, I.OmmoI) and tricyclohexylphosphine (8mg, 0.03mmol) in toluene (6ml) and water {250 pi) under a N2 atmosphere was added palladium acetate (3mg, 0.01 mmol). The mixture was heated to 100°C for 3hrs and then cooled to room temperature. Water (10ml) was added and the mixture extracted with ethyl acetate (2x15ml). The combined organic extracts were washed with brine (10ml), dried over MgSo4 and concentrated under reduced pressure to give a yellow oil. The crude product was purified by dry flash chromatography eluting with 5% MeOH in DCM. Fractions containing the product were combined and evaporated under reduced pressure to produce 29a as an orange oil. Yield 66mg, 70%. 1H nmr (250MHz. CDCb); 7.23 (1H. t, J 8.1, Chi,r), 7.10 (1H, d, J 7.8, CHar). 6.88-6.75 (5H, m, CHar), 5.70 (1H. s. CHO), 4.75 (1H. d, J 12.7, ArCHaCHb). 4.21-4,12 (1H. m. OCHaCHb). 3,84 (1H, ddd. J 2.3. 5.7, 12.6. OCHaCHb), 3.77 (3H, s, OCH3). 3.65 (1H. d, J 12.7, ArCHaCHb), 2.82 (1H. ddd, J 2.2, 8.3, 14.1, NCHaCHb), 2.62 (1H, ddd, J2.7, 5.7. 14.2, NCHaCHb), 2.45 (3H, s. NCtb), 1.77 (1H, m, CM), 0.91-0.87 (2H. m. CH2), 0.62-0.67 (2H, m. CH2). 8-Cyclopropyl-5-methyl-1 -(3-methoxy)phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocfne (29b) (Formula Removed) To a stirred solution of bromo-nefopam analogue 21b (115mg, 0.32mmol), cyclopropyi boronic arid (36mg, 0.42mmol), potassium phosphate (241 mg, 1.13mol) and tricyciohexyiphosphine (9mg, 0.03mmol) in toluene (4mi) and water (250 µL) under a N2 atmosphere was added palladium acetate (4mg, 0.02mmol). The mixture was heated to 100°C for 3hrs and then cooled to room temperature. Water (10ml) was added and the mixture extracted with ethyl acetate (2x15ml). The combined organic extracts were washed with brine (10ml), dried over MgSo4 and concentrated under reduced pressure to give a yellow oil. The crude product was purified by dry flash chromatography eluting with 5% MeOH in DCM. Fractions containing the product were combined and evaporated under reduced pressure to produce 29b as an orange oil. Yield 77mg, 75%. 1H nmr (250MHz, CDCIa); 7.22 (1H, t, J8.1, CHar), 6.94-6.76 (6H, m, Chfar), 5,74 (1H, s. CHO). 4.69 (1H. d. J 12.7. ArCiiHb). 4.14 (1H, ddd, J2.6, 8.4.12.6. OCHaHb). 3.85 (1H. ddd, J2.1, 5.8. 12.7. OCHJdb). 3.77 (3H. s. OCHar), 3.68(1H. d. J 12.7. ArCHaCHb), 2.85 (1H, ddd, J 2.0. 8.3. 14.2. NCHaCHb). 2.64 (1H. ddd. J 2.5. 5.8. 14.3, NCHaCHb), 2.49 (3H. s. NCHs). 1.86 (1H. m, Chi), 0.93 (2H. m. CH2), 0.68 (2H, m. cji). 9-Cyclopropyl-5-methyl-1 -(4-methoxy)phenyl-1,3A6-tetrahydro-5H-benz[f]-2,5-oxazocine (30a) (Formula Removed) To a stirred solution cf bromo-nefcpain analogue 17a (110mg, 0.31 mmol), cyclopropyl boronic acid (34mg, 0.40mmol), potassium phosphate (226mg, 1.Q7mmol) and tricyclohexylphosphine (9mg, 0.03mmol) In toluene (4ml) and water (200 pi) under a N2 atmosphere was added palladium acetate (4mg. 0.02mmol). The mixture was heated to 100°C for 3hrs and then cooled to room temperature. Water (10ml) was added and the mixture extracted with ethyl acetate (2x15ml). The combined organic extracts were washed with bine (10mI), dried over MgSO4 and concentrated under reduced pressure to give a yellow oil. '1He crude product was purified by dry flash chroiriatography eluting with 5% MeOH in DCM. Fractions containing the product were combined and evaporated under reduced pressure to produce 30a as an orange oil. Yield 70mg, 71%. 1H nmr (250MHz. CDCia); 7.18 (2H. d, J 8.5, CHar), 7.12 (1H, d. J 7.8, CHar), 6.88 (1 H. d. J 1.4. CH„). 6.84 (2H, d, J 8.7, CHar), 6.73 (1H, d. J 1.2, CHar). 5.68 (1H. s. CHO). 4.80 (1H. d. J 12.7 ArCHaHb). 4.18 (1H, m. OCil,Hb). 3.83 (1H. m. OCHaCHb), 3.77 (3H, s, OCMa). 3.64 (1H, d, J 12.7, ArCHaHb), 2.81 (1H, ddd. J 2.2. 8.5. 14.0, NCHaCHb), 2.60 (IN. ddd. J 2.8, 5.5, 14.0, NCHaCHb). 2.46 (3H, s. NCHa), 1.77 (1H, m, OH), 0.87 (2H, m, CH2), 0.60 (2H. m. Cjda). 8-Cyclopropyl-5-methyl-1-(4-methoxy)phenyl-1,3,4,6-tetrahydro-5H-benz[f3-2,5-oxazocJne (30b) (Formula Removed) To a stirred solution of bromo-nefopam analogue 17b (117mQ, 0.32mmol), cyclopropyl boronic acid {36mg, 0.42mmoi), potassium phosphate (241 mg, 1.13mmol) and tricyclohexylphosphine (9mg, 0.03mmol) in toluene (4ml) and water (200 µl) under a N2 atmosphere was added palladium acetate (4mg, 0.02mmol). The mixture was heated to 100°C for 3hrs and then cooled to room temperature. Water (10ml) was added and the mixture extracted with ethyl acetate (2x15ml). The combined organic extracts were washed with brine (10ml), dried over MgSo4 and concentrated under reduced pressure to give a yellow oil. The crude product was purified by dry flash chromatography elutlng with 5% MeOH In DCM. Fractions containing the product were combined and evaporated under reduced pressure to produce 30b as an orange oil. Yield 62mg, 60%. 1H nmr(250MHz, CDCIa); 7.17 (2H, d, J8.6, CHar). 6.95(1H, s. CHar). 6.84 (4H. m. CH„), 5.71 (1H, s, CtlO), 4.77 (1H. d, J 12.5. ArCHaHb), 4.17 (1H, m. OCHaCHb), 3.84 (1H. ddd, J2.3. 5.6, 12.6. OCHaCHb). 3.76 (3H, s. OCH,), 3.66 (1H, d, J 12.5, ArCHaHb). 2.84 (IN. ddd. J2.1, 8.5. 14.0, NCHaHb). 2.61 (1H, ddd, J 2.7, 5.5.14.1, NCHaCHb). 2.49 (3H, s. NCHa). 1.85 (1H. m, CH). 0.93 (2H. m, CHb). 0.67 (2H, m, CHz). 9-Methoxy-5-methyl-1-(4-methoxy)phenyl-1.3,4,6-tetrahydro-5H-benz[fl-2,5- oxazocine (31a) (Formula Removed) Ethyl acetate (0.1 ml) was added to a stirred 5M NaOMe methanol solution (1ml) under an N2 atmosphere at room temperature. Bromo-nefopam analogue 17a (104mg, 0.29mmol) in MeOH (1 ml) was then added followed by CuBr (8mg. 0.06mmol). The mixture was stirred at 75°C overnight, cooled to room temperature and quenched using water (5ml). The organic layer was separated and the aqueous was washed with ethyl acetate (2x10ml), The combined organics were dried over MgSo4, filtered and concentrated under reduced pressure. The crude product was purified by dry flash chromatography elutinq with 10% MeOH in DCM. Fractions containing the product were comtined and evaporated under reduced pressure to produce 31a as an orange oil. Yield 67mg. 71%. 1H nmr (250MHz, CDCI3); 7.18 (2H, d. J8.5. CHaCHb), 7.19 (IN. s, CHar),6.83 (2H, d, J8.6, CHar). 6.77 (1H. dd, J2.5, 8.5, CHaCHb). 6.52 (1H. d, J2.3, CHar). 5.72 (1H, s, CHO), 4.80 (1H. d. J 12.8, ArCHaCHb). 4.20 (1H. m, OCHaCHb), 3.84 (1H, ddd, J2.4. 5.1. 12.8, OCHaCHb), 3.77 (3H, s, OCH3). 3.71 (3H. s, OCH3), 3.68 (1H. d, J 12.8. ArCHaHb), 2.85 (1H, m, NCHaCHb), 2.61 (1H, m. NCHadb). 2.47 i3H, s. NCH3). 8-Nethoxy-5-methyl-1-(4-methoxy)phenyl-1,3,4,6-tetrahydro-6H-behz[f|-2,6-oxazocine (31b) (Formula Removed) Ethyl acetate (0.1 mi) was added to a stirred 5M NaOMe methanol solution (1ml) under an N2 atmosphere at room temperature. Bromo-nefopam analogue 17b (1 tSmg, 0.32mmol) in MeOH (1 mi) was then added followed by CuBr (9mg, O.OSmmol). The mixture was stirred at 75°C overnight, cooled to room temperature and quenched using water (5mi). The organic layer was separated and thei aqueous was washed with ethyl acetate (2x10ml). The combined organics were dried over MgSo4, filtered and concentrated under reduced pressure. The crude product was purified by dry flash chromatography eluting with 10% MeOH in DCM. Fractions containing the product were combined and evaporated under reduced pressure to produce 31b as an orange oii. Yield 39mg, 37%. 1H nmr (250MHz, CDCb); 7.18 (2H. d. J 8.6, CHar). 6.91 (1H. s, CHar). 6.84 (2H. d. J 8.5, Chm), 6.76 (1H, s. CHar). 6.73 (1H. d, J 2.6. CHar), 5.73 (1H, s. CHO), 4.71 (1H, d, J 12.7, ArCHaCHb), 4.13 (1H, m. OCHaHb), 3.86 (1H, m, OCHaCHb). 3.60 (3H, s. OCHar), 3.77 (3H. s. OCHa), 3.68 (1H, d. J 12./. ArCHaCHb). 2.86 (1H, m. NCHaCHb), 2.64 (1H. ddd, J 2.5, 5.7, 14.1 NCH,tlb), 2.48 (3H, s. NCHar). 9-Cyano-6-methyl-1 -(4-methoxy)phenyl-1,3,4,6-tetrahydro-5H-benz[l]-2,5- oxazocine (32a) (Formula Removed) Bromo-nefopam analogue 17a (133mg, 0.37mmol), Zn(CN)2 (65mg, 0.56mmol), and fd(PPh3)4 (63mg, 0.03mmol), were dissolved in degassed anhydrous DMF (4mL) under a N2 atmosphere. The mixture was refluxed under N2for 24 houR5. The mixture was allowed to cool to room temperatuR6, filtered through celite and washed through with DCM (50ml). The filtrate was then quenched with water (10ml) and solvent extracted. The organic extract was dried over MgSo4, filtered and solvent removed under reduced pressure. The crude product was purified by dry flash chromatography eluting with 5%-15% MeOH in DCM. Fractions containing the product were combined and evaporated under reduced pressure to produce 32a as pale brown oil. Yield 32mg, 26%. 1H nmr (250MHz, CDCb); 7.50 (1H. d, J 7.6, CHar). 7.31 (2H. d, J 9.0. CHar). 7.15 (2H, d, J 8.2, CHar). 6.86 (2H, d. J 8.2, CHar). 5.73 (1H, s. CHO), 4.91 (1H. d, J 12.8, ArCHaCHb). 4.20 (1H, m, OCHaCHb), 3.82 (4H, brm, OCHaCHb, OCHb), 3.68 (1H, d, J 12.8. ArCHJHb), 2.76 (1H. m, NCti.Hb), 2.59 (1H. m, NCHJlb). 2.44 (3H, s, NCH3). Biological Assays: The assay was carried out according to the method described In, PEROVIC, S. and MULLER, W.E.G. (1995), Pharmacological profile of hypericum extract: effect on serotonin uptake by postsynaptic receptors, Arzneim-Forsch. Drug Res., 45: 1145. Assay for Inhibition of Noradrenaline Reuptake Activity: The synaptosomes (100 pg) are incubated for 20 min at 37"C with 0.1 pCi [1H]norepinephrine in the absence (control) or presence of the test compound or the reference compound in a buffer containing 118 mM NaCI, 5 mM KCI, 2.5 mM MgSo4, 1.2 mM NaH2PO4, 25 mM NaHCOs. 11 mM glucose. 10 µM EGTAand 50 |JM ascorbic acid (pl-l 7.4). Basal control activity is determined by incubating the same mixture for 20 min at 0*C in the presence of 10 pM protriptyline to block the uptake. Following incubation, the samples are filtered rapidly under vacuum through glass fiber filters (GF/B. Packard) and rinsed twice with Ice-cold incubation buffer using a 96-sample cell harvester (Unifilter, Packard) to eliminate free [3H]norepinephrine. The filters are dried and the retained radioactivity is measured In a scintillation counter (Topcount, Packard) using a scintillation cocktail (Microscint 0, Packard). The results are expressed as a percent inhibition of the control uptake of [3H]norepinephrine. The standard inhibitory reference compound is protriptyline, which is tested in each experiment at several concentrations to obtain an inhibition curve from which its IC50 value is calculated. Assay for inhibition of Serotonin Reuptake Activity: The synaptosomes (100 µg) are Incubated for 15 min at 37*0 with 0,1µC'I [1H]seR6tonin in the absence (control) or presence of the test compound or the reference compound in a buffer containing 118 mM NaCI, 5 ml\/I KCI, 2.5 mM IVIgSO4, 1.2 mlVI NaH2PO4, 25 mlVI NaHCOs, 11 miVI glucose. 10 µM EGTA and 50 µM ascorbic acid (plH 7.4). Basal control activity is determined by incubating the same mixture for 15 min at 4*C in the presence of 10 µM imipramine to blocK the uptake. Following incubation, the samples are filtered rapidly under vacuum through glass fiber filters (GF/B, Packard) and rinsed twice with ice-cold incubation buffer using a 96-sampie cell harvester (Unifitter. Packard) to eliminate free [1H]serotonin. The filters are dried and the retained radioactivity is measured in a scintillation counter (Topcount, Packard) using a scintiHation cocktail (Microscint 0, Packard). The results are expressed as a percent inhibition of the control uptake of [3H]serotonin. The standard inhibitory reference compound is imipramine, which is tested in each experiment at several concentrations to obtain an inhibition curve from which its IC50 value is calculated. WE CLAIM: 1, A benzoxazocine compound of the general formula (1); (Formula Removed) wherein Ri is H, C1-C6 alkyl optionally substituted with F, C3-C6 cycloalkyi or C2-C6 alkenyl; either R2 and R3 are the same or different and are H, halogen, CN, CF3, Ci-Ce alkyl or OR1, or R2 and R3 form a five or six-membered ring which may be carbocyclic, heterocyclic (containing 1-2 heteroatoms selected from O, N and S), aromatic or heteroaromatic (containing 1-2 heteroatoms selected from O and N); one of W, X, Y and Z is N or CR4 and the others are each CH; R4 is halogen, CF3, CN, OR7, SO2N(R6)2, COR6, CO2R6, CON(R6)2, NR1COR5, NR-SO2R5, NR1CO2R5, NRiCON(R6)2, OC1-C6 alkyl optionally substituted with R4, C1-C6 alkyl optionally substituted with R4, C3-C6 cycloalkyi optionally substituted with R4, C2-C6 alkenyl optionally substituted with R4, C2-C6 alkynyl optionally substituted with R4, aryl optionally substituted with R4, or a five or six-membered aromatic heterocycle containing 1-4 heteroatoms selected from N and O, linked either through carbon or nitrogen, R5 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyi, aryl or heteroaryl; each R6 (which may be the same or different) is H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyi, aryl or heteroaryl; and R7 is aryl or heteroaryl; wherein aryl is an optionally substituted phenyl or naphthyl group; carbocyclic is a saturated alicyclic moeity having 5 or 6 C atoms; heterocyclic is a saturated heterocyclic moiety having 5 or 6 atoms including one or more of N, O and S; and heteroaromatic is aromatic of 5 or 6 atoms of which at least one is N, O or S; provided that (1) R4 is present and is Br, CN, CORs, CO2R6, CON(R6)2, NR1COR5, NR1SO2R5, NR1CO2R5, NR1CON(R6)2. OC1-C6 alky! substituted with R4, C1-C6 alkyl substituted with R4, C3-C6 cycloalkyi optionally substituted with R4, C2-C6 alkeynyl optionally substituted with R4, C2-C6 alkynyl optionally substituted with R4, aryl optionally substituted with R4, or a five or six-membered aromatic heterocycle containing 1-4 heteroatoms selected from N and O, linked either through carbon or nitrogen; and/or (2) R2 and R3 are not both hydrogen; or a pharmaceutically acceptable salt thereof. 2. claimed in claim 1, wherein R4 is present and is CN, OR7, SO2N(R6)2, COR6, CO2R6, CON(R6)2, NR1COR5, NR1SO2R5, NR1CON(R6)2, OC1- C6 alkyl substituted with R4, C1-C6 alkyl substituted with R4, C3-C6 cycloalkyi optionally substituted with R4, C2-C6 alkenyl optionally substituted with R4, C2-C6 alkynyl optionally substituted with R4, aryl optionally substituted with R4, or a five or six-membered aromatic heterocycle containing 1-4 heteroatoms selected from N and O, linked either through carbon or nitrogen. 3. claimed in claim 2, wherein R4 is CN, CON9(R6)2, optionally substituted cycloalkyi or aryl, or a five or six-membered aromatic heterocycle. 4. / claimed in any of claims 1 to 3, wherein R2 is halogen, CN, CF3,C1-C6 alkyl or OR1, 5. claimed in any of claims 1 to 3, wherein R2 and R3 form a ring. 6. claimed in claim 4, wherein R2 or R3 is OR1. 7 claimed in claim 1, selected from 9-methoxy-5-methyl-1-(3-methoxy)phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine (24a) 8-methoxy-5-methyl-1-(3-methoxy)phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine (24b) 9-methoxy-5-methyl-1-(4-methoxy)phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine (31a) 8-methoxy-5-methyl-1-(4-methoxy)phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine (31b). 8. A compound as claimed in claim 1, selected from 9-cyano-5-methyl-1-(3-methoxy)phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine (22a) 8-cyano-5-methyl-1-(3-methoxy)phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine (22b) 9-cyclopropyl-5-methyl-1-phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine (26a) 8-cyclopropyl-5-methyl-1-phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine (26b) N-(acetyl)-5-methyl-1-phenyl-1,3,4,6- tetrahydro-5H-benz[f]-2,5-oxazocine-9-methylamine (27a) N-(acetyl)-5-methyl-1-phenyl-1,3,4,6- tetrahydro-5H-benz[f]-2,5-oxazocine-8-methylamine (27b) 9-cyclopropyl-5-methyl-1-(3-methoxy)phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine (29a) 8-cyclopropyl-5-methyl-1-(3-methoxy)phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine (29b) 9-cyclopropyl-5-methyl-1-(4-methoxy)phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine (30a) 8-cyclopropyl-5-methyl-1-(3-methoxy)phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine (30b) and 9-cyano-5-methyl-1-(4-methoxy)phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine (32a). 9 A compound as claimed in claim 1, selected from 9-cyano-5-methyl-1-phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine (6a) 8-cyano-5-methyl-1-phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine (6b) 5-methyl-1-phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine-9-carboxamide (7a) 5-methyl-1-phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine-9-carboxamide (7b) N-(1,1,1-trimethylmethoxycarbonyl)-5-methyl-1-phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine-9-methylamine (8a) N-(1,1,1 -trimethylmethoxycarbonyl)-5-methyl-1 -phenyl-1,3,4,6- tetrahydro-5H-benz[f]-2,5-oxazocine-9-methylamine (8b) 5-methyl-1,9-diphenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine (9a) 5-methyl-1,9-diphenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine (9b) 9-(3,5-dimethylisoxazol-4-yl)-5-methyl-1-phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine (10a) 8(3,5-dimethylisoxazol-4-yl)-5-methyl-1-phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine (10b) 2-(5-methyl-1-phenyl-1,3,4,6-tetrahydro-5H-benz[f|-2,5-oxazocine-9-ethenyl)carboxamide (11a) 2-(5-methyl-1-phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine-8-ethenyl)carboxamide (11 b) 2-(5-methyl-1-phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine-9-ethyl)carboxamide (12a) 2-(5-methyl-1-phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine-8-ethyl)carboxamide (12b) 5-methyl-1-phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine-9-methylamine (13a) 5-methyl-1-piienyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine-8-methylamine (13b) N-(acetyl)-5-methyl-1-phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine-9-methylamine (27a) and N-(acetyl)-5-methyl-1-phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine-8-mettiylamine (27b). 10. A compound as claimed in claim 1, selected from 9-bromo-5-methyl-1-phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine (5a) 8-bromo-5-methyl-1-phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine (5b) 9-bromo-5-methyl-1-(4-methoxy)phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxzaocine (17a) 8-bromo-5-methyl-1-(4-methoxy)phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxzaocine (17b) 9-bromo-5-methyl-1-(3-methoxy)phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxzaocine (21a) and 8-bromo-5-methyl-1-(3-methoxy)phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxzaocine (21b). 11. A compound as claimed in any of claims 1 to 10 as and when used as a medicament for the treatment and/or prevention of conditions such as depression, post-traumatic stress disorders, attention-deficit disorders, obsessive compulsive disorders, pre-menstrual syndrome, substance abuse, miCHarrition disorders, sexual dysfunction, acute chronic or neuropathic pain and emesis.

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1904-DELNP-2005-Abstract.pdf

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1904-delnp-2005-complete specification(granted).pdf

1904-delnp-2005-correspondence-others.pdf

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1904-delnp-2005-pct-304.pdf

1904-delnp-2005-pct-409.pdf