Title of Invention

POLYSULFONE-BASE SELECTIVELY PERMEABLE HOLLOW-FIBER MEMBRANE MODULE AND PROCESS FOR PRODUCTION THEREOF

Abstract

The present invention relates to a hollow fiber membrane module comprising polysulfone type selectively permeable hollow fiber membranes which contain a polysulfone-based resin and a hydrophilic polymer as main components, wherein (A) the content of the hydrophilic polymer in the uppermost layer of the inner surface of said hollow fiber membrane is at least 1.1 time larger than the content of the hydrophilic polymer in the proximate layer of the inner surface of said membrane, and (B) the content of the hydrophilic polymer in the uppermost layer of the outer surface of said hollow fiber membrane is at least 1.1 times larger than the content of the hydrophilic polymer in the uppermost layer of the inner surface of said membrane, said hollow fiber membrane module being characterized in that (C) said hollow fiber membrane module is exposed to a radioactive ray, on condition that the oxygen concentration of an ambient atmosphere around said hollow fiber membrane is from 0.001 to 0.1%, and that the moisture content of said hollow fiber membrane to the weight thereof is from 0.2 to 7 mass %. The present invention also relates to a process for manufacturing the same hollow fiber membrane module.

Full Text

7-AZAINDOLRS AND THEIR USE AS PPAR AGONISTS Description 7-AzaindoIes, processes for their preparation and their use as pharmaceuticals 5 The invention retetes te 7-Azsindotes and to their physiologically acceptable salts and physiologically fiaictiona- derivatives showing PPAR agonist activity. PPARdelta agonists have been described in the prior art (e.g. in WO 01/00603, WO 02/092590); azaindoles are described in WO04/074284. 10 The invention was based on the object of providing compounds which permit therapeutically utilizable modulation of lipid and/or carbohydrate metabolism and are thus suitable for the prevention and/or treatment of diseases such as type 2 diabetes and atherosclerosis and the diverse sequelae thereof. 15 A series of compounds which modulate the activity of PPA receptors has been found. The compounds are suitable in particular for activating PPARdelta and PPARalpha, however the extent of the relative activation can vary depending on the compounds. 20 Compounds of the present invention are described by formula I: the N atom to which they are attached a 4, 5 or 6-membered saturated, partly saturated or unsaturated heterocycle wherein a C atom may be replaced by N, O, S, SO, S02; 5 X as well as their physioiogicaly acceptable salts. Preference is given to compounds of the formula I wherein phenyl is substituted by R9 10 only. Furthermore preference is given to compounds of the formula I wherein R9 is in para-position. 15 Preference is given to compounds of the formula I where one or more substituent has the following meaning NR10SO2-(C1-C6)alkyi, (C1-C6) alkylen-OCONR10R11, (C1-C6) alkylen-NR10COR11, (C1-C6) alkylen-NR10CONR11 where alkyi may substituted with one or more fluorine or phenyl atoms and where n may be 0,1 or 2; 5 R8 H; R9 CF3; 10 R10.R11 H, (C1-C6)-alkyl or (C3-C6)-cycloalkyl optionally substituted with one to three F, heteroaryl; R10 and R11 may form together with the N atom to which they are attached a 4, 5 or 6-membered heterocycle wherein a C atom may be replaced by N, O, S, SO, S02. 15 X -CH2-. Preference is given also to compounds of the formula I where one or more substituent has the following meaning 20 cycloalkyi, (C2-C6) alkenyl, phenyl, O-phenyl, where alkyl may substituted with one or more fluorine or phenyl atoms and where n may be 0,1 or 2; 5 R8 H; R9 CF3: X -CH2-. 10 Particular preference is given to the compounds of the formula l,wherein This invention also encompasses ail combinations of preferred aspects of the invention described herein. 25 The alkyl and alkenyl radicals in the substituents R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 may be either straight-chain or branched and maybe substituted by one to four fluorine atoms. Unless otherwise indicated the term heteroaryl refers to aromatic, mono- or bicyclic 30 rings having 4 to 11 carbon atoms, wherein at least one carbon atom is replaced by a heteroatom selected from the group consisting of N, O or S. The compounds of the formula I may exist in the form of their racemates, racemic mixtures, pure enantiomers, diastereomers and mixtures of diastereomers as well in their tautomeric forms. The present invention encompasses all these isomeric and tautomeric forms of the compounds of the formula I. These isomeric forms can be obtained by known methods even if not specifically described in some cases. Pharmaceutical^ acceptable salts are, because their solubility in water is greater than that of the initial or basic compounds, particularly suitable for medical applications. These salts must have a pharmaceuticaliy acceptable anion or cation. Suitable pharmaceutically acceptable acid addition salts of the compounds of the invention are salts of inorganic acids such as hydrochloric acid, hydrobromic, phosphoric, metaphosphoric, nitric and sulfuric acid, and of organic acids such as, for example, acetic acid, benzenesulfonic, benzoic, citric, ethanesulfonic, fumaric, gluconic, glycolic, isethionic, lactic, lactobionic, maleic, malic, methanesulfonic, succinic, p-toluenesulfonic and tartaric acid. Suitable pharmaceutically acceptable basic salts are ammonium salts, alkali metal salts (such as sodium and potassium salts), alkaline earth metal salts (such as magnesium and calcium salts), and salts of trometamol (2-amino-2-hydroxymethyl-1,3-propanediol), diethanolamine, lysine or ethylenediamine. Salts with a pharmaceutically unacceptable anion such as, for example, trifluoroacetate likewise belong within the framework of the invention as useful intermediates for the preparation or purification of pharmaceutically acceptable salts and/or for use in nontherapeutic, for example in vitro, applications. The term "physiologically functional derivative" used herein refers to any physiologically tolerated derivative of a compound of the formula I of the invention, for example an ester, which on administration to a mammal such as, for example, a human is able to form (directly or indirectly) a compound of the formula I or an active metabolite thereof. Physiologically functional derivatives also include prodrugs of the compounds of the invention, as described, for example, in H. Okada et al., Chem. Pharm. Bull. 1994, 42, 57-61. Such prodrugs can be metabolized in vivo to a compound of the invention. These prodrugs may themselves be active or not. The compounds of the rrvenaor may also exist in various polymorphous forms, for example as amorphous &nd crysnsi&ie polymorphous forms. All polymorphous forms of the compounds of the inversion belong within the framework of the invention and are a further aspect of the invention. All references to "compound(s) formula I" hereinafter refer to compound(s) of the formula I as described above, and their salts, solvates and physiologically functional derivatives as described herein. Use This invention relates further to the use of compounds of the formula I and their pharmaceutical compositions as PPAR ligands. The PPAR ligands of the invention are suitable as modulators of PPAR activity. Peroxisome proliferator-activated receptors (PPAR) are transcription factors which can be activated by ligands and belong to the class of nuclear hormone receptors. There are three PPAR isoforms, PPARalpha, PPARgamma and PPARdelta (identical to PPARbeta), which are encoded by different genes (Peroxisome proliferator-activated receptor (PPAR): structure, mechanisms of activation and diverse functions: Motojima K., Cell Struct Funct, 1993, 18(5), 267-77). In humans, PPARgamma exists in three variants, PPARgamma,, gamma2, and gamma3, which are the result of alternative use of promoters and differential mRNA splicing. Different PPARs have different tissue distribution and modulate different physiological functions. The PPARs play a key role in various aspects of the regulation of a large number of genes, the products of which genes are directly or indirectly crucially involved in lipid and carbohydrate metabolism. Thus, for example, the PPARaipha receptor plays an important part in the regulation of fatty acid catabolism or lipoprotein metabolism in the liver, while PPARgamma is crucially involved for example in regulating adipose cell differentiation. In addition, however, PPARs are also involved in the regulation of many other physiological processes, including those which are not directly connected with carbohydrate or lipid metabolism. The activity of different PPARs can be modulated by various fatty acids, fatty acid derivatives and synthetic compounds to varying extents. For relevant reviews about functions, physiological effects and pathophysiology, see: Berger, J. et alM Annu. Rev. Med., 2002, 53, 409-435; Wilson, T. et aL, J. Med. Chem., 2000, 43 (4), 527-550; Kliewer, S. et al., Recent Prog Horm Res., 2001, 56, 239-63; Moller, D.E. and Berger, J.P., Int J Obes Relat Metab Disord., 2003, 27 Suppl 3, 17-21; Ram, V.J., Drugs Today, 2003, 39(8),609-32). Among the three PPAR-isoforms the physiological functions of PPARdelta have long remained an enigma. The first proposed pharmacological role for PPARdelta has been the regulation of cholesterol homeostasis. It was shown that the somewhat selective PPARdelta ligand L-165041 raises plasma cholesterol in a diabetic animal model (Berger J. et alM J. Biol. Chem., 1999, 274, 6718-6725; Leibowitz M.D. et aL, FEBS Lett., 2000,473(3), 333-336). In obese, insulin resistant rhesus monkeys, the potent and selective PPARdelta ligand GW501516 raises HDL-cholesterol, decreases plasma LDL-cholesterol, triglycerides and insulin levels (Oliver, W. et aL, Proc. Natl. Acad. ScL, 2001, 98, 5306-5311). The dual PPARdelta/PPARalpha agonist YM-16638 significantly lowers plasma lipids in rhesus and cynomolgus monkeys (Goto, S. et aL, Br. J. Pharm., 1996,118,174-178) and acts in a similar manner in two weeks clinical trials in healthy volunteers (Shimokawa, T. et aL, Drug Dev. Res., 1996, 38, 86-92). More recent publications underline that PPARdelta is an important target for the treatment of dyslipidemia, insulin resistance, type 2 diabetes, atherosclerosis and syndrom X (Wang,Y-X. et aL, Cell, 2003, 113, 159-170; Luquet, S. et aL, FASEB JM 2003, 17, 209-226 ; Tanaka, T. et aL, PNAS, 2003, 100, .15924-15929 ; Hoist, D. et al., BioChem. Biophys. Acta, 2003,1633, 43-50; Dressel, U. et aL, Mol. Endocrin., 2003, 17, 2477-2493 ; Lee, C.H. et aL, Science, 2003, 302, 453-457). Besides its actions as a regulator of the lipid-, glucose- and cholesterol-metabolism PPARdelta is known to play a rote in embryonic development, implantation and bone formation (Urn, H. and Dey, S.K, Trends Endocrinol Metab,, 2000,11(4),137-42; Ding, N.Z. et a!., Mol Reprod Dev., 2003. 86(3), 218-24; Mano, H. et al., J Biol Chem., 2000, 275(11), 8126-32). Numerous publications demonstate that PPARdelta is triggering proliferation and differentiation of keratinocvfes which points to its role in skin disorders and wound healing (Di-Poi, N. et al., J Steroid Biochem Mol Biol., 2003, 85(2-5), 257-65; Tan, N.S. et al., Am J Clin Dermatol., 2003,4(8), 523-30; Wahli, W., Swiss Med Wkly., 2002, 132(7-8),83-91). PPARdelta appears to be significantly expressed in the CNS; however much of its function there still remains undiscovered. Of singular interest however, is the discovery that PPARdelta was expressed in rodent oligodendrocytes, the major lipid producing cells of the CNS (J. Granneman, et al., J. Neurosci. Res., 1998, 51, 563-573). Moreover, ft was also found that a PPARdelta selective agonist was found to significantly increase oligodendroglial myelin gene expression and myelin sheath diameter in mouse cultures (I. Saluja et al., Glia, 2001, 33, 194-204). Thus, PPARdelta activators may be of use for the treatment of demyelinating and dysmyelinating diseases. Demyelinating conditions are manifested in loss of myelin - the multiple dense layers of lipids and protein which cover many nerve fibers. These layers are provided by oligodendroglia in the central nervous system (CNS), and Schwann cells in the peripheral nervous system (PNS). In patie/rts with demyelinating conditions, demyelination may be irreversible; it is usually accompanied or followed by axonal degeneration, and often by cellular degeneration. Demyelination can occur as a result of neuronal damage or damage to the myelin itself - whether due to aberrant immune responses, local injury, ischemia, metabolic disorders, toxic agents, or viral infections (Prineas and McDonald, Demyelinating Diseases. In Greenfield's Neuropathology, 6.sup.th ed. (Edward Arnold: New York, 1997)813-811, Beers and Berkow, eds., The Merck Manual of Diagnosis and Therapy, 17.sup.th ed. (Whitehouse Station, N.J.: Merck Research Laboratories, 1999) 1299, 1437, 1473-76, 1483). Central demyelination (demyelination of the CNS) occurs in several conditions, often of uncertain etiology, that have come to be known as the primary demyelinating diseases. Of these, multiple sclerosis (MS) is the most prevalent. Other primary demyelinating diseases include adrenoleukodystrophy (ALD), adrenomyeloneuropathy, AIDS-vacuolar myelopathy, HTLV-associated myelopathy, Leber's hereditary optic atrophy, progressive multifocal leukoencephalopathy (PML), subacute sclerosing panencephalitis, Guillian-Barre syndrome and tropical spastic paraparesis. In addition, there are acute conditions in which demyelination can occur in the CNS, e.g., acute disseminated encephalomyelitis (ADEM) and acute viral encephalitis. Furthermore, acute transverse myelitis, a syndrome in which an acute spinal cord transection of unknown cause affects both gray and white matter in one or more adjacent thoracic segments, can also result in demyelination. Also, disorders in which myelin forming glial cells are damaged including spinal cord injuries, neuropathies and nerve injury. The present invention relates to compounds of the formula I suitable for modulating the activity of PPARs, especially the activity of PPARdelta and PPARalpha. Depending on the modulation profile, the compounds of the formula I are suitable for the treatment, control and prophylaxis of the indications described hereinafter, and for a number of other pharmaceutical applications connected thereto (see, for example, Berger, J., et al., Annu. Rev. Med., 2002, 53, 409-435; Wilson, T. et ah, J. Med. Chem., 2000,43(4), 527-550; Kliewer, S. et al., Recent Prog Horm Res., 2001, 56, 239-63; Fruchart, J.C. et al., 2001, Pharmacological Research, 44(5), 345-52; Kersten, S. et a!., Nature, 2000, 405,421-424; Torra, LP. et al., Curr Opin Lipidol, 2001,12, 245-254). Compounds of this type are particularly suitable for the treatment and/or prevention of: 1. - Disorders of fatty acid metabolism and glucose utilization disorders. - Disorders in which insulin resistance is involved 2. Diabetes mellitus, especially type 2 diabetes, including the prevention of the sequelae associated therewith. Particular aspects in this connection are - hyperglycemia, - improvement in insulin resistance, - improvement in glucose tolerance, - protection of the pancreatic S cells - . prevention of macrc- and microvascular disorders 3. Dysiipidemias and thgr sac&alae such as, for example, atherosclerosis, coronary heart disease, cerebrovascLfe'disorders etc, especially those (but not restricted thereto) which are characterisd by one or more of the following factors: - high plasma triglyceride concentrations, high postprandial plasma triglyceride concentrations, - low HDL cholesterol concentrations - low ApoA lipoprotein concentrations - high LDL cholesterol concentrations - small dense LDL cholesterol particles r - high ApoB lipoprotein concentrations 4. Various other conditions which may be associated with the metabolic syndrome, such as: - obesity (excess weight), including central obesity - thromboses, hypercoagulahle and prothrombotic states (arterial and venous) - high blood pressure - heart failure such as, for example (but not restricted thereto), following myocardial infarction, hypertensive heart disease or cardiomyopathy 5. Disorders or conditions in which inflammatory reactions are involved: - atherosclerosis such as, for example (but not restricted thereto), coronary sclerosis including angina pectoris or myocardial infarction, stroke - vascular restenosis or reocclusion - chronic inflammatory bowel diseases such as, for example, Crohn's disease and ulcerative colitis - asthma - lupus erythematosus (LE) or inflammatory rheumatic disorders such as, for example, rheumatoid arthritis - other inflammatory states 6. Disorders of cell cycle or cell differentiation processes: - adipose cell tumors - lipomatous carcinomas such as, for example, liposarcomas - solid tumors and neoplasms such as, for example (but not restricted thereto), carcinomas of the gastrointestinal tract, of the liver, of the biliary tract and of the pancreas, endocrine tumors, carcinomas of the lungs, of the kidneys and the urinary tract, of the genital tract, prostate carcinomas etc - acute and chronic myeloproliferative disorders and lymphomas - angiogenesis 7. CNS disorders, neurodegenerative disorders and/or demyelinating disorders: - Alzheimer's disease - multiple sclerosis - Parkinson's disease - adrenoleukodystrophy (ALD) - adrenomyeioneuropathy - AlDS-vacuolar myelopathy - HTLV-associated myelopathy - Leber's hereditary optic atrophy - progressive multifocal leukoencephalopathy (PML) - subacute sclerosing panencephalitis - Guillian-Barre syndrome - tropical spastic paraparesis - acute disseminated encephalomyelitis (ADEM) - acute viral encephalitis - acute transverse myelitis - spinal cord and brain trauma - Charot-Marie-Tooth disease 8. Skin disorders and/or disorders of wound healing processes: - erythemato-squamous dermatoses such as, for example, psoriasis - acne vulgaris - other skin disorders aid demiatological conditions which are modulated by PPAR - eczemas and neurodermos - dermatitis such asT fer^sn^fe, seborrheic dermatitis or photodermatitis - keratitis and keratoses such as, for example, seborrheic keratoses, senile keratoses, actinic keratosis, photo-induced keratoses or keratosis follicularis - keloids and keloid prapnyfecs - warts, including condylomata or condylomata acuminata - human papilloma viral (HPV) infections such as, for example, venereal papillomata, viral warts such as, for example, molluscum contagiosum, leukoplakia - papular dermatoses such as, for example, Lichen planus - skin cancer such as, for example, basal-cell carcinomas, melanomas or cutaneous T-cell lymphomas - localized benign epidermal tumors such as, for example, keratoderma, epidermal naevi - chilblains - wound healing 9. Other disorders - high blood pressure - pancreatitis - syndrome X - polycystic ovary syndrome (PCOS) - asthma - osteoarthritis - lupus erythematosus (LE) or inflammatory rheumatic disorders such as, for example, rheumatoid arthritis - vasculitis - wasting (cachexia) - gout - ischemia/reperfusion syndrome - acute respiratory distress syndrome (ARDS) Formulations The amount of a compound of formula I necessary to achieve the desired biological effect depends on a number of factors, for example the specific compound chosen, the intended use, the mode of administration and the clinical condition of the patient The daily dose is generally in the range from 0.001 mg to 100 mg (typically from 0.01 mg to 50 mg) per day and per kilogram of bodyweight, for example 0.1-10 mg/kg/day. An intravenous dose may be, for example, in the range from 0.001 mg to 1.0 mg/kg, which can suitably be administered as infusion of 10 ng to 100 ng per kilogram and per minute. Suitable infusion solutions for these purposes may contain, for example, from 0.1 ng to 10 mg, typically from 1 ng to 10 mg, per milliliter. Single doses may contain, for example, from 1 mg to 10 g of the active ingredient. Thus, ampules for injections may contain, for example, from 1 mg to 100 mg, and single-dose formulations which can be administered orally, such as, for example, capsules or tablets, may contain, for example, from 0.05 to 1000 mg, typically from 0.5 to 600 mg. For the therapy of the abovementioned conditions, the compounds of formula I may be used as the compound itself, but they are preferably in the form of a pharmaceutical composition with an acceptable carrier. The carrier must, of course, be acceptable in the sense that it is compatible with the other ingredients of the composition and is not harmful for the patient's health. The carrier may be a solid or a liquid or both and is preferably formulated with the compound as a single dose, for example as a tablet, which may contain from 0.05% to 95% by weight of the active ingredient. Other pharmaceutical^ active substances may likewise be present, including other compounds of formula I. The pharmaceutical compositions of the invention can be produced by one of the known pharmaceutical methods, which essentially consist of mixing the ingredients with pharmacologically acceptable carriers and/or excipients. Pharmaceutical compositions of the invention are those suitable for oral, rectal, topical, peroral (for example sublingual) and parenteral (for example subcutaneous, intramuscular, intradermal or intravenous) administration, although the most suitable mode of administration depends In each individual case on the nature and severity of the condition to be treated arxi or the nature of the compound of formula 1 used in each case. Coated fbfmuisDQOS SK! coated slow-release formulations also belong within the frameworic of the invsraoR. Preference is given to acid- and gastric juice-resistant formulations. Suitable codings resistant to gastric juice comprise cellulose acetate phthalate, polyvinyl acetate phthalate, hydroxypropylmethylcellulose phthalate and anionic polymers of msfhaoyBc 3cid and methyl methacrylate. Suitable pharmaceutical preparations for oral administration may be in the form of separate units such as, for example, capsules, cachets, suckable tablets or tablets, each of which contain a defied amount of the compound of formula I; as powders or granules, as solution or suspension in an aqueous or nonaqueous liquid; or as an oil-in-water or water-irvoil emulsion. These compositions may, as already mentioned, be prepared by any suitable pharmaceutical method which includes a step in which the active ingredient and the carrier (which may consist of one or more additional ingredients) are brought into contact The compositions are generally produced by ) uniform and homogeneous mixing of the active ingredient with a liquid and/or finely divided solid carrier, after which the product is shaped if necessary. Thus, for example, a tablet can be produced by compressing or molding a powder or granules of the compound, where appropriate with one or more additional ingredients, Compressed tablets can be produced by tableting the compound in free-flowing form such as, for > example, a powder or granules, where appropriate mixed with a binder, glidant, inert diluent and/or one (or more) surface-active/dispersing agent(s) in a suitable machine. Molded tablets can be produced by molding the compound, which is in powder form and is moistened with an inert liquid diluent, in a suitable machine. 3 Pharmaceutical compositions which are suitable for peroral (sublingual) administration comprise suckable tablets which contain a compound of formula I with a flavoring, normally sucrose and gum arabic ortragacanth, and pastilles which comprise the compound in an inert base such as gelatin and glycerol or sucrose and gum arabic. Pharmaceutical compositions suitable for parenteral administration comprise preferably sterile aqueous preparations of a compound of formula I, which are preferably isotonic with the blood of the intended recipient. These preparations are preferably administered intravenously, although administration may also take place by subcutaneous, intramuscular or intradermal injection. These preparations can preferably be produced by mixing the compound with water and making the resulting solution sterile and isotonic with blood. Injectable compositions of the invention generally contain from 0.1 to 5% by weight of the active compound. Pharmaceutical compositions suitable for rectal administration are preferably in the form of single-dose suppositories. These can be produced by mixing a compound of the formula I with one or more conventional solid carriers, for example cocoa butter, and shaping the resulting mixture. Pharmaceutical compositions suitable for topical use on the skin are preferably in the form of ointment cream, lotion, paste, spray, aerosol or oil. Carriers which can be used are petrolatum, lanolin, polyethylene glycols, alcohols and combinations of two or more of these substances. The active ingredient is generally present in a concentration of from 0.1 to 15% by weight of the composition, for example from 0.5 to 2%. Transdermal administration is also possible. Pharmaceutical compositions suitable for transdermal uses can be in the form of single plasters which are suitable for long-term close contact with the patient's epidermis. Such plasters suitably contain the active ingredient in an aqueous solution which is buffered where appropriate, dissolved and/or dispersed in an adhesive or dispersed in a polymer. A suitable active ingredient concentration is about 1% to 35%, preferably about 3% to 15%. A particular possibility is for the active ingredient to be released by electrotransport or iontophoresis as described, for example, in Pharmaceutical Research, 2(6): 318 (1986). The compounds of the formula I are distinguished by favorable effects on metabolic disorders. They beneficially influence lipid and sugar metabolism, in particular they lower the triglyceride level and are suitable for the prevention and treatment of type II diabetes and arteriosderuss and the diverse sequalae thereof. Combinations with other nnecScsnents The compounds of the inventoi can be administered alone or in combination with one or more further pharmacologically active substances which have, for example, • favorable effects on metabGic distances or disorders frequently associated therewith. Examples of such medicaments are 1. medicaments which lower blood glucose, antidiabetics, 2. active ingredients for the treatment of dyslipidemias, 3. antiatherosderotic medicaments, » 4. antiobesity agents, 5. antiinflammatory active ingredients 6. active ingredients for the treatment of malignant tumors 7. antithrombotic active ingredients 8. active ingredients for the treatment of high blood pressure ) 9. active ingredients for the treatment of heart failure and 10. active ingredients for the treatment and/or prevention of complications caused by diabetes or associated with diabetes. They can be combined with the compounds of the invention of the formula I in 5 particular for a synergistic improvement in the effect Administration of the active ingredient combination can take place either by separate administration of the active ingredients to the patient or in the form of combination products in which a plurality of active ingredients are present in one pharmaceutical preparation. 0 Examples which may be mentioned are: Antidiabetics Suitable antidiabetics are disclosed for example in the Rote Liste 2001, chapter 12 or in the USP Dictionary of USAN and International Drug Names, US Pharmacopeia, Rockville 2001. Antidiabetics include all insulins and insulin derivatives such as, for ; example, Lantus® (see www.lantus.com) or Apidra®, and other fast-acting insulins (see US 6,221,633), GLP-1 receptor modulators as described in WO 01/04146 or else, for example, those disclosed in WO 98/08871 of Novo Nordisk A/S. The orally effective hypoglycemic active ingredients include, preferably, sulfonylureas, biguanides, megiitinides, oxadiazoiidinediones\ thiazolidinediones, glucosidase inhibitors, glucagon antagonists, GLP-1 agonists, DPP-IV inhibitors, potassium channel openers such as, for example, those disclosed in WO 97/26265 and WO 99/03861, insulin sensitizers, inhibrtors of liver enzymes involved in the stimulation of giuconeogenesis and/or glycogenolysis, modulators of glucose uptake, compounds which alter lipid metabolism and lead to a change in the blood lipid composition, compounds which reduce food intake, PPAR and PXR modulators and active ingredients which act on the ATP-dependent potassium channel of the beta cells. In one embodiment of the invention, the compounds of the formula I are administered in combination with insulin. In one embodiment of the invention, the compounds of the formula I are administered in combination with substances which influence hepatic glucose production such as, for example, glycogen phosphorylase inhibitors (see: WO 01/94300, WO 02/096864, WO 03/084923, WO 03/084922, WO 03/104188) In one embodiment, the compounds of the formula I are administered in combination with a sulfonylurea such as, for example, tolbutamide, glibenclamide, glipizide or glimepiride. In one embodiment, the compounds of the formula I are administered in combination with an active ingredient which acts on the ATP-dependent potassium channel of the beta cells, such as, for example, tolbutamide, glibenclamide, glipizide, glimepiride or repaglinide. In one embodiment the conpouncs of the formula I are administered in combination with a biguanide such asT for sxsrpis. metformin. In a further embodiment, the compounds of the formula I are administered in combination with a rneglitirKfe such s, for example, repaglinide. In one embodiment, the compounds of the formula I are administered in combination with a thiazolidinedione such as, for trample, ciglitazone, pioglitazone, rosiglitazone or the compounds disclosed in WO 97/41097 of Dr. Reddy's Research Foundation, in particular 5-[[4-[(3,4HJihydro-3^^ thiazolidinedione. In one embodiment, the compounds of the formula I are administered in combination with a DPPIV inhibitor as described, for example, in W098/19998, W099/61431, W099/67278, W099/67279, WO01/72290, WO 02/38541, WO03/040174, in particular P 93/01 (1-cyclopentyl-3-methyl-1-oxo-2-pentanammonium chloride), P-31/98, LAF237 (1-[2-[3-hydroxyadamant-1-yiamir^ ((2S, 4S)-4-fluoro-1-[[(2-hydroxy-^ monobenzenesulfonate). In one embodiment of the invention, the compounds of the formula i are administered in combination with a PPARgamma agonist such as, for example, rosiglitazone, pioglitazone. In one embodiment, the compounds of the formula I are administered in combination with compounds with an inhibitory effect on SGLT-1 and/or 2, as disclosed directly or indirectly for example in WO 2004/007517, WO 2004/052902, and WO 2004/052903. In one embodiment, the compounds of the formula I are administered in combination with an a-glucosidase inhibitor such as, for example, miglitol or acarbose. In one embodiment, the compounds of the formula I are administered in combination with more than one of the aforementioned compounds, e.g. in combination with a sulfonylurea and metformin, a sulfonylurea and acarbose, repaglinide and metformin, insulin and a sulfonylurea, insulin and metformin, insulin and troglitazone, insulin and lovastatin, etc. Lipid modulators In one embodiment of the invention, the compounds of the formula I are administered in combination with an HMGCoA reductase inhibitor such as lovastatin, fluvastatin, pravastatin, simvastatin, ivastatin, itavastatin, atorvastatin, rosuvastatin. In one embodiment of the invention, the compounds of the formula I are administered in combination with a bile acid reabsorption inhibitor (see, for example, US 6,245,744, US 6,221,897, US 6,277,831, EP 0683 773, EP 0683 774). In one embodiment of the invention, the compounds of the formula I are administered in combination with a polymeric bile acid adsorbent such as, for example, i cholestyramine, colesevelam. In one embodiment of the invention, the compounds of the formula I are administered in combination with a cholesterol absorption inhibitor as described for example in WO 0250027, or ezetimibe, tiqueside, pamaqueside. " In one embodiment of the invention, the compounds of the formula I are administered in combination with an LDL receptor inducer (see, for example, US 6,342,512). In one embodiment, the compounds of the formula I are administered in combination > with bulking agents, preferably insoluble bulking agents (see, for example, carob/Caromax® (Zunft H J; et al., Carob pulp preparation for treatment of hypercholesterolemia, ADVANCES IN THERAPY (2001 Sep-Oct), 18(5), 230-6.) Caromax is a carob-containing product from Nutrinova, Nutrition Specialties & Food Ingredients GmbH, Industriepark Boechst, 65926 Frankfurt/Main)). Combination with Caromax® is possible in one preparation or by separate administration of compounds of the formula I and CarornaxS. Caranrax® can in this connection also be ! administered in the form of KXXI products such as, for example, in bakery products or muesli bars. in one embodiment of the invention, the compounds of the formula I are administered in combination with a PPARaipha agonist. In one embodiment of the invention, the compounds of the formula I are administered in combination with a fibrate such as, for example, fenofibrate, gemfibrozil, clofibrate, bezafibrate. In one embodiment of the invention, the compounds of the formula I are administered in combination with nicotinic acid or niacin. In one embodiment of the invention, the compounds of the formula I are administered in combination with a CETP inhibitor, e.g. CP- 529, 414 (torcetrapib). In one embodiment of the invention, the compounds of the formula I are administered in combination with an ACAT inhibftor. In one embodiment of the invention, the compounds of the formula I are administered in combination with an MTP inhibitor such as, for example, implitapide. In one embodiment of the invention, the compounds of the formula I are administered in combination with an antioxidant. In one embodiment of the invention, the compounds of the formula I are administered in combination with a lipoprotein lipase inhibitor. In one embodiment of the invention, the compounds of the formula I are administered in combination with an ATP citrate lyase inhibitor. In one embodiment of the invention, the compounds of the formula I are administered in combination with a squalene synthetase inhibitor. In one embodiment of the invention, the compounds of the formula I are administered in combination with a lipoprotein(a) antagonist. Antiobesity agents In one embodiment of the invention, the compounds of the formula I are administered in combination with a lipase inhibitor such as, for example, orlistat. In one embodiment, the further active ingredient is fenfluramine or dexfenfluramine. In another embodiment, the further active ingredient is sibutramine. In a further embodiment, the compounds of the formula I are administered in combination with CART modulators (see "Cocaine-amphetamine-regulated transcript influences energy metabolism, anxiety and gastric emptying in mice" Asakawa, A, et a!., M.: Hormone and Metabolic Research (2001), 33(9), 554-558), NPY antagonists, e.g. naphthalene-1-sulfonic acid {4-[(4-aminoquinazolin-2-ylamino)methyI]-cyclohexyimethyl}amide hydrochloride (CGP 71683A)), MC4 agonists (e.g. 1-arnino-1,2,3,4-tetrahydronaphthaIene-2-carboxyIicacid [2-(3a-benzyl-2-methyl-3«oxo-2r3,3a,4,6,7-hexahydropyrazolo[4,3-c]pyridin-5-yl)-1-(4-chloroptieriyl)-2-oxoethyl]-amide; (WO 01/91752)), orexin antagonists (e.g. 1-(2-methyibenzoxazol-6-yl)-3-[1,5]naphthyridin-4-ylurea hydrochloride (SB-334867-A)), H3 agonists (3-cydohexyl-1-(4,4-dimethyl-1,4,6,7-tetrahydroimidazo[4,5-c]pyridin-5-yl)propan-1-one oxalic acid salt (WO 00/63208)); TNF agonists, CRF antagonists (e.g. [2-methyl-9-(2,4,6-trimethylphenyl)-9H-1,3,9-triazafluoren-4-yl]dipropylamine (WO 00/66585)), CRF BP antagonists (e.gr urocortin), urocortin agonists, (33 agonists (e.g. 1-(4-chloro-3- methanesulfonyimeltiyiphenyf}-2-{2-{2,3-dim^ hydrochloride (WO 01/83451)), MSH (melanocyte-stimulating hormone) agonists, CCK-A agonists (e.g. {2-[4-(4-chtoro-Z5-dime ethyi)thiazole-2-ylrarirarrTOyi?^ acid trifluoroacetic acid salt (WO 99/15525)), serotonin nsupfefcB inhibitors (e.g. dexfenfluramine), mixed serotoninergic and noradrenergic compounds (e.g. WO 00/71549), 5HT agonists e.g. 1-(3-ethylbenzofura?v7-yl)piperszFe cxalic acid salt (WO 01/09111), bombesin agonists, galanin antagonists, gro*£h hormone (e.g. human growth hormone), growth hormone-releasing compounds (S-benzyloxy-1 -(2-diisopropylaminoethylcarbamoyI)- 3,4 agonists (see, for example, EP 0 462 884), uncoupling protein 2 or 3 modulators, leptin agonists (see, for example, Lee, Daniel W.; Leinung, Matthew C; Rozhavskaya-Arena, Marina; Grasso, Patricia. Leptin agonists as a potential approach to the treatment of obesity. Drugs of the Future (2001), 26(9), 873-881), DA agonists (bromocriptine, Doprexin), lipase/amylase inhibitors (e.g. WO 00/40569), PPAR modulators (e.g. WO 00/78312), RXR modulators orTR-p agonists. In one embodiment of the invention, the further active ingredient is leptin. In one embodiment, the further active ingredient is dexamphetamine, amphetamine, mazindole or phentermine. In one embodiment, the compounds of the formula I are administered in combination with medicaments having effects on the coronary circulation and the vascular system, such as, for example, ACE inhibitors (e.g. ramipril), medicaments which act on the angiotensin-renine system, calcium antagonists, beta blockers etc. In one embodiment, the compounds of the formula I are administered in combination with medicaments having an antiinflammatory effect. In one embodiment, the compounds of the formula I are administered in combination with medicaments which are employed for cancer therapy and cancer prevention. It will be appreciated that every suitable combination of the compounds of the invention with one or more of the aforementioned compounds and optionally one or more other pharmacologically active substances is regarded as falling within the protection conferred by the present invention. The activity of the compounds was tested as follows: Determination of EC50 values of PPAR agonists in the cellular PPARalpha assay i Principle The potency of substances which bind to human PPARalpha and activate it in an agonistic manner is analyzed using a stably transfected HEK cell line (HEK= human : embryo kidney) which is referred to here as PPARalpha reporter cell line. It contains two genetic elements, a luctferase reporter element (pdeltaM-GAL4-Luc-Zeo) and a PPARalpha fusion protein (GR-GAL4-humanPPARalpha-LBD) which mediates expression of the luciferase reporter element depending on a PPARalpha iigand. The stably and constitutively expressed fusion protein GR-GAL4-humanPPARalpha-LBD ) binds in the cell nucleus of the PPARalpha reporter cell line via the GAL4 protein portion to the GAL4 DNA binding motifs 5'-upstream of the luciferase reporter element which is stably integrated in the genome of the cell line. There is only weak expression of the luciferase reporter gene in the absence of a PPARalpha Iigand if fatty acid-depleted fetal calf serum (cs-FCS) is used in the assay. PPARalpha ligands bind and ; activate the PPARalpha fusion protein and thereby stimulate the expression of the luciferase reporter gene. The luciferase which is formed can be detected by means of chemiluminescence via an appropriate substrate. Construction of the PPARalpha reporter cell line ) The PPARalpha reporter cell line was prepared in two stages. Firstly, the luciferase reporter element was constructed and stably transfected into HEK cells. For this purpose, five binding sites of the yeast transcription factor GAL4 (Accession # AF264724) were cloned in 5'-upstream of a 68 bp-long minimal MMTV promoter (Accession # V01175). The minima! MMTV promoter section contains a CCAAT box and a TATA element m order fc enable efficient transcription by RNA polymerase II. The cloning and sec^jancing of the GAL4-MMTV construct took place in analogy to the description of Sambrook J. st al (Kfotecular cloning, Cold Spring Harbor Laboratory Press, 1989). Then the compters Pbo&ius pyralis gene (Accession # M15077) was cloned in 3'-downstream of the GAL4-4IMTV element. After sequencing, the luciferase reporter element consisting of five GAL4 binding sites, MMTV promoter and luciferase gene was recloned ink* a plescnati wrier confers zeocin resistance in order to obtain the plasmid pdeltaM-GAL4-Luc-Zeo. This vector was transfected into HEK cells in accordance with the statements in Ausubel, F.M. et al. (Current protocols in molecular biology, Vol. 1-3, John Wiley & Sons, Inc., 1995). Then zeocin-containing medium (0.5 mg/ml) was used to select a suitable stable cell clone which showed very low basal expression of the luceiiferase gene. In a second step, the PPARalpha fusion protein (GR-GAL4-humanPPARaIpha-LBD was introduced into the stable cell clone described. For this purpose, initially the cDNA coding for the N-termina! 76 amino acids of the glucocorticoid receptor (Accession # P04150) was linked to the cDNA section coding for amino acids 1 -147 of the yeast transcription factor GAL4 (Accession # P04386). The cDNA of the ligand-binding domain of the human PPARalpha receptor (amino acids S167-Y468; Accession # S74349) was cloned in at the 3'-end of this GR-GAL4 construct. The fusion construct prepared in this way (GR-GAL4~humanPPARalpha-LBD) was recloned into the plasmid pcDNA3 (invitrogen) in order to enable constitutive expression therein by the cytomegalovirus promoter. This plasmid was linearized with a restriction endonuclease and stably transfected into the previously described cell clone containing the luciferase reporter element. The finished PPARalpha reporter cell line which contains a luciferase reporter element and constitutively expresses the PPARalpha fusion protein (GR-GAL4-human PPARalpha-LBD) was isolated by selection with zeocin (0.5 mg/ml) and ' G418 (0.5 mg/ml). ssay procedure he activity of PPARalpha agonists is determined in a 3-day assay which is described elow: )ay1 "he PPARalpha reporter cell line is cultivated to 80% confluence in DMEM (# 41965-I39, Invitrogen) which is mixed with the following additions: 10% cs-FCS (fetal calf ;erum; #SH-30068.03, Hyclone), 0.5 mg/ml zeocin (#R250-01, Invitrogen), 0.5 mg/ml 5418 (#10131-027, Invitrogen), 1% penicillin-streptomycin solution (#15140-122, nvitrogen) and 2 mM L-giutamine (#25030-024, Invitrogen). The cultivation takes )lace in standard cell culture bottles (# 353112, Becton Dickinson) in a cell culture ncubator at 37DC in the presence of 5% CO2. The 80%-confluent cells are washed )nce with 15 ml of PBS (#14190-094, Invitrogen), treated with 3 ml of trypsin solution #25300-054, invitrogen) at 37°C for 2 min, taken up in 5 ml of the DMEM described and counted in a cell counter. After dilution to 500.000 cells/ml, 35,000 cells are seeded in each well of a 96 well microtiter plate with a clear plastic base (#3610, doming Costar). The plates are incubated in the cell culture incubator at 37°C and 5% Z02 for 24 h. Day 2 PPARalpha agonists to be tested are dissolved in DMSO in a concentration of 10 mM. This stock solution is diluted in DMEM (#41965-039, Invitrogen) which is mixed with 5% cs-FCS (#SH-30068.03, Hyclone), 2 mM L-glutamine (#25030-024, Invitrogen) and the previously described antibiotics (zeocin, G418, penicillin and streptomycin). Test substances are tested in 11 different concentrations in the range from 10 \iM to 100 pM, More potent compounds are tested in concentration ranges from 1 pM to 10 pM or between 100 nM and 1 pM. The medium of the PPARalpha reporter cell line seeded on day 1 is completely removed by aspiration, and the test substances diluted in medium are immediately added to the cells. The dilution and addition of the substances is carried out by a robot (Beckman FX). The final volume of the test substances diluted in medium is 100 pi per well of a 96 well microtiter plate. The DMSO concentration in the assay is less than 0.1 % v/v in order to avoid cytotoxic effects of the solvent. Each plate was charged with a standard PPARalpha agonist, which was likewise diluted in 11 different coricentrsooos- in order to demonstrate the functioning of the assay in each indivktal plas. The assay plates are incubated in an incubator at 37°C and 5% C02 for 24 h. Day 3 The PPARalpha reporter cells treated with the test substances are removed from the incubator, and the medium e qsptrarari off. The cells are lyzed by pipetting 50 pi of Bright Glo reagent (from Promega) into each well of a 96 well microtiter plate. After incubation at room temperature in the dark for 10 minutes, the microtiter plates are measured in the luminometer (Trilux from Wallac). The measuring time for each well of a microtiter plate is 1 sec. Evaluation The raw data from the luminometer are transferred into a Microsoft Excel file. Dose-effect plots and EC50 values of PPAR agonists are calculated using the XLFit program as specified by ihe manufacturer (IDBS). Principle The potency of substances which bind to human PPARdelta and activate it in an agonistic manner is analyzed using a stably transfected HEK cell line (HEK= human embryo kidney) which is referred to here as PPARdelta reporter cell line. In analogy to the assay described for PPARalpha, the PPARdelta reporter cell line also contains two genetic elements, a luciferase reporter element (pde!taM-GAL4-Luc-Zeo) and a PPARdelta fusion protein (GR-GAL4-humanPPARdelta-LBD) which mediates expression of the luciferase reporter element depending on a PPARdelta ligand. The stably and constitutively expressed fusion protein GR-GAL4-humanPPARdeIta-LBD binds in the cell nucleus of the PPARdelta reporter cell line via the GAL4 protein portion to the GAL4 DNA binding motifs 5'-upstream of the luciferase reporter element which is stably integrated in the genome of the cell line. There is only little expression of the luciferase reporter gene in the absence of a PPARdelta ligand if fatty acid-depleted fetal calf serum (cs-FCS) is used in the assay. PPARdelta ligands bind and activate the PPARdelta fusion protein and thereby stimulate expression of the luciferase reporter gene. The luciferase which is formed can be detected by means of chemiluminescence via an appropriate substrate. Construction of the PPARdelta reporter cell line The production of the stable PPARdelta reporter cell line is based on a stable HEK-cell clone which was stably transfected with a luciferase reporter element. This step was already described above in the section "construction of the PPARalpha reporter cell line". In a second step, the PPARdelta fusion protein (GR-GAL4-humanPPARdelta-LBR was stably introduced into this cell clone. For this purpose, the cDNA coding for the N-terminal 76 amino acids of the glucocorticoid receptor (Accession # P04150) was linked to the cDNA section coding for amino acids 1-147 of the yeast transcription factor GAL4 (Accession # P04386). The cDNA of the ligand-binding domain of the human PPARdelta receptor (amino acids S139-Y441; Accession # L07592) was cloned in at the 3'-end of this GR-GAL4 construct. The fusion construct prepared in this way (GR-GAL4-humanPPARdelta-LBD) was recloned into the plasmid pcDNA3 (Invitrogen) in order to enable constitutive expression by the cytomegalovirus promoter. This plasmid was linearized with a restriction endonuclease and stably transfected into the previously described cell clone containing the luciferase reporter element. The resulting PPARdelta reporter cell line which contains a luciferase reporter element and constitutively expresses the PPARdelta fusion protein (GR-GAL4-human PPARdelta-LBD) was isolated by selection with zeocin (0.5 mg/ml) and G418 (0.5 mg/ml). ' Assay procedure and evaluation The activity of PPARdelta agonists is determined in a 3-day assay in exact analogy to the procedure already described for the PPARaipha reporter cell line except that the PPARdelta reporter cell line and a spedfic PPARdelta agonist was used as a standard to control test efficacy. The potency of the described sxsnptes are indicated in the following table : A 5-Methoxy-7-azaindoie of the general formula A, where R3,R4,R5 and R6 are as defined above is reacted with a phenyithiazole-methylhalide or-mesylate or —tosylate of general formula B, where X, R7, R8 and R9 are as defined above, in presence of a base, e.g sodium hydride in a solvent as dimethytformamide to give a compound of the general formula C. The compound of the general formula C is converted to the product of general formula D by reaction with borontribromide in a solvent as dichloromethane. The compound of the general formula D is reacted with a bromoacetic acid derivative of general formula E where R1 und R2 are as defined above in presence of a base as cesium carbonate in a polar aprotic solvent as dimethylformamide to give a compound of the general formula F. The compound of general formula F is converted to a compound of general formula G upon treatment with an acid as trifiuoro-acetic acid in an apolar solvent as dichloromethane. Example 1 was obtained according to process A. Other compounds can be obtained accordingly or by known processes. I I The compound of general formula D where R3=H and R4, R5,R6, R7, R8,R9 and X are as defined above is reacted with allylbromide in the presence of a base as cesium carbonate in a polar aprotic solvent as dimethylformamide to give a compound of general formula H. The compound of general formula H is rearranged to a compound of general formula I upon heating, e.g in a microwave. The compound of the general formula I is reacted with a bromoacetic acid derivative of general formula E where R1 and R2 are defined above in presence of a base as cesium carbonate in a polar aprotic solvent as dimethyiformamide to give a compound of the general formula K. The compound of general formula K is converted to a compound of general formula L upon treatment with an acid as trifluoro-acetic acid in an apolar solvent as dichloromethane. The compound of general formula L is converted to a compound of 5 general formula M upon treatment with hydrogen in the presence of a catalyst as palladium. Example 2 was onbtained according to process B. 0 Other compounds can be obtained accordingly or by known processes. process C: 5 This process is used for synthesizing the building block B where X = CH2 and R7,R8 and R9 are as defined above. A 3-Oxo-butyric acid methyl- or ethyl ester of general formula N where R7 is as defined above is reacted with sulfuryl chloride to a chlorine substituted compound of general formula O. This compound of general formula O is reacted with a thiobenzamide of general formula P, where R8 and R9 are as defined above to obtain a phenyithiazole ester of genera! formula Q. The eser CH general formula Q is reduced with a reducing agent ,e.g. lithium aluminium hydride, tD the alcohol of general formula R. The alcohol of general formula R is reacted wsh rrethanesulfonyl chloride in the presence of a base as triethylamine in a solvent as akidoromethane to obtain the building block of general formula S. Other compounds can be obtained accordingly or by known processes. List of abbreviation: Further compounds of the formula I can be prepared correspondingly or by known processes. The experimental procedures for preparing the examples mentioned above are described below: 5.0 g 3-Oxoheptanoic acid methyl ester were dissolved in 80 ml dry dichloromethane and 2.82 ml sulfurylchloride were added. The reaction mixture was stirred at room temperature for 30 minutes. 20 ml of water were added and the reaction mixture extracted five times with portions of 30 ml of dichloromethane. The combined organic extracts were washed with water and saturated NaHC03 solution and brine and dried over MgS04. The solvent was removed under reduced pressure to obtain 6.0 g 2-ChIoro-3-oxo-heptanoic acid methyl ester as raw material. This material was used without further purification. 6.0 g 2-Chloro-3-oxo-heptanoic acid methyl ester were dissolved in 50 ml ethanol and 6.4 g 4~(Trifluoromethyl)thiobenzamide were added. The reaction mixture was heated under reflux overnight. The solvent was removed under reduced pressure and the residue purified by chromatography with the eluent n-heptane:ethyl acetate = 100:1 => 60:1. This gives 7.4 g 4-Butyl-2-(44rifluoromethyl~ phenyI)-thiazol-5- carboxylic acid methyl ester as yellow oil. C16H16F3N02S (343.37), MS(ESI): 344.1 (M+H+), Rf(n-heptane: ethyl acetate = 4:1) = 0.62. 1.2 g lithium aluminium hydride were dissolved in 100 ml dry tetrahydro-furan. 5.3 g 4-) Butyl-2-(4»trifluormethy!-phenyl)-thiazol-5- carboxylic acid methyl ester, dissolved in 100 ml tetrahydro-furan, were added. The reaction mixture was stirred at room temperature over a period of one hour, then 50 ml saturated ammonium chloride solution and 50 ml of a 1 molar hydrochloric acid solution was added. The reaction mixture was extracted five times with portions of 60 ml of ethyl acetate. The combined organic layers were dried over MgS04 and the solvent removed under reduced pressure to provide 4.6 g [4-Butyl-2»(4"trifluoromethyI-phenyI)-thiazole-5-yI]-methanol as a yellow oil, which solidified upon standing at room temperature. C15H16F3NOS (315.36), MS(ESI): 316.4 (M+H+). 1.0 g [4~Butyl-2-(44rifluorome^ were dissolved in 50 ml dichloromethane, 0.88 ml triethylarnine and 0.39 ml methanesulfonyl chloride were added. The reaction mixture was ^rrea si room temperature for a period of three hours then 100 ml of dichloromethane were added and the reaction mixture washed with 50 ml of saturated NaHC03 solution , water and and brine. The organic layer was dried over MgS04 and the solvent removed under reduced pressure. This provided 1.0 g 4-Butyl-5-chlorometh>4-2-(4-tr7fiuoromethyl-phenyI)-thiazole as yellow oil. C15H15CIF3NS (333.81), MS(ESI): 334.3 (M+H+). stirred at room temperature'for one hour then 100 ml ethyl acetate were added and the mixture was washed five times with portions of 20 ml of water The organic layer was dried over MgS04 and the solvent removed under reduced pressure. The residue was dissolved in 10 ml dichtoromethane and 4 ml trifluoroacetic acid were added. The reaction mixture was stirred at room tsrmerature for three hours then 100 ml toluene were added and the solvents removed under reduced pressure. The residue was purified by RP-HPLC to provide '55 rag {1-p5-Butyl-2-(4-trifluoromethyI-phenyl)-thia2ol«5-ylmethyI]-1H-pyrrolo[2T343pyri 5-yloxy}-acetic acid as lyophilisate. C24H22F3N303S (489.52), LCMSfESi); 490.2(M+H+). b]pyridin- 5-o! were dissolved in 20 ml dimethylformamide and 1.1 mg cesium carbonate and 410 mg allylbromide were added. The reaction mixture was stirred at room temperature for one hour then 100 ml ethyl acetate were added and the mixture was washed five times with portions of 20 ml of water The organic layer was dried over MgS04 and the solvent removed under reduced pressure. This gives 800 mg 5-Allyloxy-1-[4-butyi-2-(4-trifluoro b]pyridine as yellow oil. C25H24F3N30S (471.55), LCMS(ESI): 47Z2 (M+H+). pyrrolo[2,3- b]pyridine were dissolved in 15 ml dimethylformamide and was stirred under microwave irridiation (Personal chemistry / 200°C) for two hours. The cooled mixture was evaporated in vacuo and the resulting crude material was purified by reversed phase HPLC. The byproduct 6-AIIyl-1-[4-butyl-2-(4«trifluoromethyl-phenyl)-thiazol-5-ylmethyI]-1H-pyrrolo[2,3- b]pyridin-5-ol was separated to provide 140 mg 4-Allyl-1 -[4-butyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethyr|-1 H-pyrrolo[2,3- b]pyridin-5-ol as lyophilisate. C25H24F3N30S (471.55), LCMS(ESI): 472.5 (M+H+). 140 mg 4-AIIyM-[4-butyI-2-(44r) H- pyrrolo[2,3- b]pyridin-5-oI were dissolved in 10 ml dimethyiformamide and 195 mg caesium carbonate and 116 mg terL-buiytbromoacetate were added. The reaction mixture was stirred at roomo hours then 100 ml ethyl acetate were added and the mixture waswith portions of 20 ml of water The organic layer was dried ove*olvent removed under reduced pressure. The residue was cjichloromethane and 4 ml trifluoroacetic acid were added. The reactirred at room temperature for three hours then 100 ml toluene were a The residue was dissolved i 2nd 50 mg palladium (10% on charcoal) were added. The reaction mixture was stirred at room temperature in a hydrogen atmosphere (5 bar) for one hour. The catalyst was filtered off and the solvent removed under reduced pressure. The residue was purified by RP-HPLC to provide 70 mg {1-[4- Butyl-2-(44rifluoromethyl-phenyI b]pyridin~ 5-yloxy}-acetic acid as colourless lyophilisate. C27H28F3N303S (531.60), LCMS(ESI): 532.3 (M+H+). CLAIMS [1] A hollow fiber membrane module comprising polysulfone type selectively permeable hollow fiber membranes which contain a polysulfone-based resin and a hydrophilic polymer as main components, wherein (A) the content of the hydrophilic polymer in the uppermost layer of the inner surface of said hollow fiber membrane is at least 1.1 time larger than the content of the hydrophilic polymer in the proximate layer of the inner surface of said membrane, and (B) the content of the hydrophilic polymer in the uppermost layer of the outer surface of said hollow fiber membrane is at least 1.1 times larger than the content of the hydrophilic polymer in the uppermost layer of the inner surface of said membrane, said hollow fiber membrane module being characterized in that (C) said hollow fiber membrane module is exposed to a radioactive rayf on condition that the oxygen concentration of an ambient atmosphere around said hollow fiber membrane is from 0.001 to 0.1%, and that the moisture content of said hollow fiber membrane to the weight thereof is from 0.2 to 7 mass %. [2] The hollow fiber membrane module according to claim 1, wherein said radiation exposure is done while said hollow fiber membrane module is sealed in a packaging bag. [3] The hollow fiber membrane module according to claim 1 or 2, wherein said radiation exposure is done under an internal atmosphere of said bag, of which the relative humidity is higher than 40%RH at 25°C. [4] The hollow fiber membrane module according to any one of claims 1 to 3, wherein said radiation exposure is done after at least 10 hours has passed since an oxygen scavenger was put in the packaging bag. [5] The hollow fiber membrane module according to claim 4, wherein said oxygen scavenger has a function to release a moisture content. [6] The hollow fiber membrane module according to any one of claims 1 to 5, wherein said packaging bag is made of a material which shuts out an external air and a water vapor. [7] The hollow fiber membrane module according to any one of claims 1 to 6, wherein the oxygen permeability of said packaging bag is not larger than 1 cm3/(m2.24h.atm) (20°C and 90%RH). [8] The hollow fiber membrane module according to any one of claims 1 to 7, wherein the water vapor permeability of said packaging bag is not larger than 5 g/(m .24h.atm) (40°C and 90%RH) . [9] The hollow fiber membrane module according to any one of claims 1 to 8, wherein the inner atmosphere of said packaging bag and/or the ambient atmosphere of said hollow fiber membrane are/is of an inert gas. [10] The hollow fiber membrane module according to any one of claims 1 to 9, wherein the amount of an aqueous solution of potassium permanganate (2.0 X 10"3 mol/L) consumed for the titration of an eluted substance in 10 mL of an initial washing liquid from the hollow fiber membrane module after the radiation exposure is not larger than 5 mL per 1 m2 of the inner surface of the hollow fiber membrane. [11] The hollow fiber membrane module according to any one of claims 1 to 10, wherein the amount of hydrogen peroxide eluted from the hollow fiber membrane which is removed from the hollow fiber membrane module after at least 3 months has passed since the radiation exposure is not larger than 10 ppm. [12] The hollow fiber membrane module according to any one of claims 1 to 11, wherein the uppermost layer of the inner surface of the polysulfone type hollow fiber membrane is a layer having a depth of up to 10 nm from the inner surface of the hollow fiber membrane, and the proximate layer is a layer having a depth of from 1,000 to 1,500 nm (from 1 to 1.5 jam) from the inner surface of the hollow fiber membrane. [13] The hollow fiber membrane module according to any one of claims 1 to 12, wherein the content of the hydrophilic polymer in the polysulfone type hollow fiber membrane is 20 to 40 mass % in the uppermost layer of the inner surface, 5 to 20 mass % in the proximate layer thereof, and 25 to 50 mass % in the uppermost layer of the outer surface. [14] The hollow fiber membrane module according to any one of claims 1 to 13, which comprises 99 to 80 mass % of the polysulfone-based resin and 1 to 20 mass % of the hydrophilic polymer as main components. [15] The hollow fiber membrane module according to any one of claims 1 to 14, wherein said hydrophilic polymer is polyvinyl pyrrolidone. [16] The hollow fiber membrane module according to any one of claims 1 to 15, wherein the amount of the hydrophilic polymer eluted from the hollow fiber membrane is not larger than 10 ppm. [17] The hollow fiber membrane module according to any one of claims 1 to 16, wherein the ratio of pore areas of the outer surface of the hollow fiber membrane is from 8% inclusive to less than 25%. [18] The hollow fiber membrane module according to any one of claims 1 to 17, wherein said hydrophilic polymer is crosslinked and insolubilized. [19] A process for manufacturing a hollow fiber membrane module comprising polysulfone type selectively permeable hollow fiber membranes which contain a polysulfone-based resin and a hydrophilic polymer as main components, wherein (A) the content of the hydrophilic polymer in the uppermost layer of the inner surface of said hollow fiber membrane is at least 1.1 time larger than the content of the hydrophilic polymer in the proximate layer of the inner surface of said membrane, and (B) the content of the hydrophilic polymer in the uppermost layer of the outer surface of said hollow fiber membrane is at least 1.1 times larger than the content of the hydrophilic polymer in the uppermost layer of the inner surface of said membrane, said process being characterized in that (C) said hollow fiber membrane module is exposed to a radioactive ray, on condition that the oxygen concentration of an ambient atmosphere around said hollow fiber membrane is from 0.001 to 0.1%, and that the moisture content of said hollow fiber membrane to the weight thereof is from 0.2 to 7 mass %. [20] The process according to claim 19, wherein said radiation exposure is done while said hollow fiber membrane module is sealed in a packaging bag. [21] The process according to claim 19 or 20, wherein said radiation exposure is done under an internal atmosphere of said bag, of which the relative humidity is higher than 40%RH at 25°C. [22] The process according to any one of claims 19 to 21, wherein said radiation exposure is done after at least 10 hours has passed since an oxygen scavenger was put in the packaging bag. [23] The process according to any one of claims 19 to 22, wherein the amount of hydrogen peroxide eluted from the hollow fiber membrane which is removed from the hollow fiber membrane module after at least 3 months has passed since the radiation exposure is not larger than 10 ppm. [24] The process according to any one of claims 19 to 23, wherein the uppermost layer of the inner surface of the polysulfone type hollow fiber membrane is a layer having a depth of up to 10 run from the inner surface of the hollow fiber membrane, and the proximate layer is a layer having a depth of from 1,000 to 1,500 nm (from 1 to 1.5 jam) from the inner surface of the hollow fiber membrane. [25] The process according to any one of claims 19 to 24, wherein the content of the hydrophilic polymer in the polysulfone type hollow fiber membrane is 20 to 40 mass % in the uppermost layer of the inner surface, 5 to 2 0 mass % in the proximate layer thereof, and 25 to 50 mass % in the uppermost layer of the outer surface. [26] The process according to any one of claims 19 to 25, which said hollow fiber membrane module comprises 99 to 80 mass % of the polysulfone-based resin and 1 to 20 mass % of the hydrophilic polymer as main components. [27] The process according to any one of claims 19 to 26, wherein the amount of the hydrophilic polymer eluted from the hollow fiber membrane is not larger than 10 ppm.

Documents:

1018 CHENP 2007 - Petition for POR.pdf

1018-CHENP-2007 AMENDED PAGES OF SPECIFICATION 15-05-2013.pdf

1018-CHENP-2007 AMENDED CLAIMS 15-05-2013.pdf

1018-CHENP-2007 AMENDED CLAIMS 24-03-2014.pdf

1018-CHENP-2007 AMENDED PAGES OF SPECIFICATION. 24-03-2014.pdf

1018-CHENP-2007 CORRESPONDENCE OTHERS 07-08-2013.pdf

1018-CHENP-2007 CORRESPONDENCE OTHERS 17-09-2013.pdf

1018-CHENP-2007 CORRESPONDENCE OTHERS 18-12-2012.pdf

1018-CHENP-2007 EXAMINATION REPORT REPLY RECEIVED 15-05-2013.pdf

1018-CHENP-2007 EXAMINATION REPORT REPLY RECEIVED 24-03-2014.pdf

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1018-CHENP-2007 FORM-3 15-05-2013.pdf

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1018-CHENP-2007 FORM-5 24-03-2014.pdf

1018-CHENP-2007 OTHER PATENT DOCUMENT 15-05-2013.pdf

1018-CHENP-2007 OTHERS 15-05-2013.pdf

1018-CHENP-2007 POWER OF ATTORNEY 15-05-2013.pdf

1018-CHENP-2007 POWER OF ATTORNEY 17-09-2013.pdf

1018-CHENP-2007 FORM-6 10-12-2007.pdf

1018-chenp-2007 assignment.pdf

1018-chenp-2007 correspondence -others.pdf

1018-chenp-2007 correspondence others.pdf

1018-chenp-2007 form-3.pdf

1018-chenp-2007 form-6.pdf

1018-chenp-2007-abstract.pdf

1018-chenp-2007-claims.pdf

1018-chenp-2007-correspondnece-others.pdf

1018-chenp-2007-description(complete).pdf

1018-chenp-2007-form 1.pdf

1018-chenp-2007-form 3.pdf

1018-chenp-2007-form 5.pdf

1018-chenp-2007-pct.pdf