Title of Invention	PROCESS FOR PRODUCING (Z)-1-PHENYL-1-(N,N-DIETHYLAMINOCARBONYL)-2-PHTHALIMIDOMETH YLCYCLOPROPANE
Abstract	The present invention provides a process for producing (z)-1-phenyl-1-(N,N- diethylaminocarbonyl)-2-phthalimidomethylcyclopropane, which includes reacting (z)-1- phenyl-1-(N,N-diethylaminocarbonyl)-2-aminomethylcycl opropane hydrochloride through the above process.

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DESCRIPTION PROCESS FOR PRODUCING (Z)-1-PHENYL-1-(N,N-DIETHYLAMINOCARBONYL)-2-PHTHALIMIDOMETH YLCYCLOPROPANE TECHNICAL FIELD The present invention relates to a novel process for producing (Z)-1-phenyl-1-(N,N-diethylaminocarbonyl)-2-aminomethylcycl opropane hydrochloride, which is useful as an antidepresent, and (Z)-1-phenyl-1-(N,N-diethylaminocarbonyl)-2-phthalimidometh. ylcyclopropane as an intermediate thereof. BACKGROUND ART (Z)-1-phenyl-1-(N,N-diethylaminocarbonyl)-2-phthalim idomethylcyclopropane (hereafter, may be referred to as the (Z) -phthalimidomethylcyclopropane compound) is an intermediate of a (Z)-1-phenyl-1-(N,N-diethylaminocarbonyl)-2-aminomethylcycl opropane hydrochloride (hereafter, (Z)-1-phenyl-1-(N,N-diethylaminocarbonyl)-2-aminomethylcycl opropane may be sometimes referred to as the (Z)-aminomethylcyclopropane compound, and (Z)-1-phenyl-1-(N,N-diethylaminocarbonyl)-2-aminomethylcycl opropane hydrochloride may be sometimes referred to as the (Z)-aminomethylcyclopropane compound hydrochloride, respectively), which is useful as an antidepresent. Conventionally, there has been known a process for producing the (Z) -phthalimidomethylcyclopropane compound, which comprises chlorinating (Z)-1-phenyl-1-(N,N-diethylaminocarbonyl)-2-hydroxymethylcy clopropane (hereafter, may be referred to as the (Z) -hydroxymethylcyclopropane compound) with thionyl chloride to obtain (Z)-1-phenyl-1-(N,N-diethylaminocarbonyl)-2-chloromethylcyc lopropane, and reacting the product with a phthalimide salt (see, JP2964041-B). DISCLOSURE OF THE INVENTION An object of the present invention is to provide a process for producing the (Z)-phthalimidomethylcyclopropane compound and further the (Z)-aminomethylcyclopropane compound hydrochloride at high yield by a simple operation without using a reagent which may generate sulfur dioxide, such as, thionyl chloride, and a low boiling point halogenated hydrocarbon solvent. The object and other objects of the present invention will become apparent from the following descriptions. That is, the present invention is as follows. A process for producing (Z)-1-phenyl-1-(N,N-diethylaminocarbonyl)-2-phthalimidometh ylcyclopropane which comprises reacting (Z)-1-phenyl-1-(N,N-diethylaminocarbonyl)-2-hydroxymethylcy clopropane with an orthoester and a br0nsted acid, and then reacting the reaction product with a phthalimidating agent. The process according to , wherein the reaction product of (Z)-1-phenyl-1-(N,N-diethylaminocarbonyl)-2-hydroxymethylcy clopropane, an orthoester and a br0nsted acid is an iminium salt of the formula (I) wherein A" represents conjugated base of a br0nsted acid. The process according to or , wherein the br0nsted acid is methanesulfonic acid. The process according to any of to , wherein the orthoester is an orthoformic alkyl ester. The process according to , wherein the orthoformic alkyl ester is triethyl orthoformate or trimethyl orthof ormate. The process according to any of to , wherein the phthalimidating agent is (1) a phthalimide potassium salt or (2) phthalimide and a base. The process according to , wherein the base is at least one selected from the group consisting of potassiumtert-but oxide, sodium methoxide, potassium carbonate and triethylamine. The process according to any of to , wherein (Z)-hydroxymethylcyclopropane compound is the compound obtainedby reacting 2-oxo-1-phenyl-3-oxabicyclo [3.1.0] hexane with diethylamine in the presence of an alkali metal alkoxide. A process for producing (Z)-aminomethylcyclopropane compound hydrochloride which comprises a step reacting (Z)-hydroxymethylcyclopropane compound with an orthoester and a br0nsted acid to obtain reaction product, a step reacting the reaction product with phthalimidating agent to obtain (Z)-phthalimidomethylcyclopropane compound, a step reacting (Z)-phthalimidomethylcyclopropane compound with aqueous methylamine to obtain (Z) -aminomethylcyclopropane compound, and a step treating (Z)-aminomethylcyclopropane compound with hydrogen chloride. An iminium salt of the formula (I) wherein A" represents conjugated base of a br0nsted acid. The iminium salt according to Claim 10, wherein A- is CH3SO3-. MODE FOR CARRYING OUT THE INVENTION Hereinafter, the present invention will be described in detail. The process for producing the (Z)-phthalimidometihylcyclopropane compound of the present invention includes the first step wherein the (Z)-hydroxymethylcyclopropane compound is reacted with an orthoester and a br0nsted acid to produce an iminium salt (hereafter, may be referred to as the iminium salt (I) ) of the formula (I): wherein A- represents conjugated base of a br0nsted acid, and the second step wherein the iminium salt (I) is reacted with a phthalimidating agent. The first step can be conducted, for example, by mixing the (Z)-hydroxymethylcyclopropane compound, an orthoester and a br0nsted acid in a solvent. Although an addition order is not particularly limited, a method of adding an orthoester to the (Z)-hydroxymethylcyclopropane compound and then adding a br0nsted acid is preferable. The orthoester is not particularly limited and easily available ones can be used. Examples thereof include orthoformicacid alkyl esters (such as trimethyl orthoformate and triethyl orthoformate) , orthoaceticacid alkyl esters (such as trimethyl orthoacetate and triethyl orthoacetate) , orthobutyricacid alkyl esters (such as trimethyl orthobutyrate and triethyl orthobutyrate) and orthobenzoicacid alkyl esters (such as trimethyl orthobenzoate and triethyl orthobenzoate), among which orthoformicacid alkyl esters are preferable, and trimethyl orthoformate and triethyl orthoformate are more preferable. The amount of the orthoester is preferably from 1 to 10 g equivalents based on 1 g equivalent of the (Z)-hydroxymethylcyclopropane compound, and more preferably from 1.2 to 2 g equivalents, in view of prevention of generation of material residues or by-products, and reaction efficiency. The br0nsted acid is not particularly limited and easily available ones can be used. Examples thereof include methanesulfonic acid, toluenesulfonic acid, trifluoromethanesulfonic acid, sulfuric acid and hydrogen chloride, among which methanesulfonic acid is preferable in view of reactivity. The amount of the bronsted acid is preferably from 1 to 10 g equivalents based on 1 g equivalent of the (Z)-hydroxymethylcyclopropane compound, and more preferably from 1 to 1. 5 g equivalents, in view of completion of the reaction or reaction efficiency. The first step can generally be conducted in a solvent, and an orthoester can also serve as the solvent. The solvent is not limited as long as it does not inhibit the reaction, and hydrocarbon solvents such as toluene and aprotic polar solvents such as N, N-dimethylformamide can be used alone or in combination. The amount of the solvent is preferably 5 parts by weight or less based on 1 part by weight of the (Z)-hydroxymethylcyclopropane compound. The reaction temperature of the first step is generally from 0 to 100°C, and preferably from 20 to 40°C. The reaction time is generally from 1 to 24 hours, and preferably from 1 to 10 hours. In the reaction mixture after completion of the first step, the iminium salt (I), its counter ion is conjugated base of the used br0nsted acid, is contained. The reaction mixture, as it is, can be used for the second step. The first step and the second step can be conducted in the same reaction vessel, so called in one-pot. In such a case, before the second step, the reaction mixture after completion of the first step can be concentrated and substituted by another solvent. Also, the iminium salt (I) can be isolated by removing the solvent under reduced pressure, and may be optionally purified by conventional means such as decantation with an organic solvent or chromatography. The iminium salt (I) produced in the first step is a novel compound, and a useful synthetic intermediate of the (Z)-aminomethylcyclopropane compound hydrochloride as an antidepresent. A- in the iminium salt (I) is preferably CH3SO3". The second step can be conducted, for example, by mixing the reaction mixture after completion of the first step or the isolated iminium salt (I) with a phthalimidating agent in a solvent. Although an addition order is not particularly limited, a method of adding dropwise the reactionmixture after completion of the first step to the phthalimidating agent is preferable. As the phthalimidating agent, a phthalimide salt is used. Examples thereof include phthalimide potassium salt, phthalimide sodium salt and phthalimide triethylamine salt, among which phthalimide potassium salt is preferred. The amount of the phthalimidating agent is preferably from 1 to 10 g equivalents based on 1 g equivalent of the (Z)-hydroxymethylcyclopropane compound (1 g equivalent of the iminium salt (I), assuming that the yield of the iminium salt (I) in the first step is 100%) that is used in the first step, and more preferably from 1 to 2 g equivalents, in view of completion of the reaction or reaction efficiency. The phthalimide salt may be produced from phthalimide and a base in a reaction system. In this case, examples of the base include at least one kind of potassium tert-butoxide, sodium methoxide, potassium carbonate, triethylamine and the like. The amount of the base is preferably from 1 to 10 g equivalents, and more preferably from 1 to 2 g equivalents, based on 1 g equivalent of phthalimide. The second step is preferably conducted in a solvent. Examples of the solvent include single solvents and mixed solvents such as aprotic polar organic solvents (such as N,N-dimethylformamide, N,N-dimethylacetoamide, N,N'-dimethylimidazolidinone and N-methyl pyrrolidone) and protic organic solvents (such as methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, tert-butanol, ethylene glycol and propylene glycol) , among which aprotic polar organic solvents are preferred in view of reactivity, and N,N-dimethylformamide and N,N-dimethylacetoamide are particularly preferred. The amount of the solvent is preferably from 1 to 50 parts by weight based on 1 part by weight of the (Z) -hydroxymethylcyclopropane compound that is used in the first step. The reaction temperature of the second step is generally from 0 to 150°C, and preferably from 20 to 80°C. The reaction time is generally from 1 to 20 hours, and preferably from 1 to 5 hours. After completion of the second step, the (Z) -phthalimidomethylcyclopropane compound can be isolated and purified by a conventional method. For example, isolation can be conducted by adding water or the like to the reaction mixture, filtering and washing the precipitated crystal, or extracting the reaction mixture with an organic solvent, followed by washing with water, and concentration. Furthermore, purification may be conducted by crystallization or chromatography. The (Z)-aminomethylcyclopropane compound hydrochloride, which is useful as an antidepresent, can be derived from the (Z)-phthalimidomethylcyclopropane compound obtained by the present invention by a known method. For example, as described in Japanese Examined Patent Publication No. 5-67136, the (Z)-aminomethylcyclopropane compound hydrochloride can be derived by reacting the (Z)-phthalimidomethylcyclopropane compound with an aqueous methylamine solution to obtain the (Z)-aminomethylcyclopropane compound, and treating the compound with hydrogen chloride. The (Z)-hydroxymethylcyclopropane compound is a known compound, and as described in JPH02-262558-A, for example, the compound can be produced by reacting 2-oxo-1-phenyl-3-oxabicyclo[3.1.0]hexane (see Synthesis, 1978, 304-305) with diethylamine in the presence of a Lewis acid amine complex. However, since a low boiling point halogenated hydrocarbon such as dichloroethane is required in this method, there arises an environmental problem similarly to the above described conventional process for producing the (Z)-phthalimidomethylcyclopropane compound. Accordingly, a method of reacting 2-oxo-1-phenyl-3-oxabicyclo [3.1.0] hexane with diethylamine in the presence of an alkali metal alkoxide, which is proposed by the present inventors, is preferable. The method can be conducted, for example, by mixing 2-oxo-1-phenyl-3-oxabicyclo[3.1.0]hexane, diethylamine and an alkali metal alkoxide in a solvent. The amount of diethylamine is generally from 1 to 10 g equivalents, and preferably from 2 to 4 g equivalents, based on 1g equivalent of 2-oxo-1-phenyl-3-oxabicyclo[3.1.0]hexane. Examples of the alkali metal alkoxide include alkali metal salts of an alcohol having 1 to 4 carbon atoms, such as lithium methoxide, sodium methoxide, potassium methoxide, lithium ethoxide, sodium ethoxide, potassium ethoxide, sodium t-butoxide and potassium t-butoxide. Sodium methoxide or potassium methoxide is preferred, and sodium methoxide is particularly preferred. The amount of the alkali metal alkoxide is generally from 1 to 5 g equivalents, and preferably from 1.5 to 4 g equivalents, based on 1 g equivalent of 2-oxo-1-phenyl-3-oxabicyclo[3.1.0]hexane. The form of the alkali metal alkoxide is not particularly limited, and it may be in the form of solid or solution. When a solution is used, a solution of the alcohol solvent corresponding to an alkali metal alkoxide to be used (for example, sodium methoxide in methanol) is preferably selected. The alcohol solvent is contained as a portion of a reaction solvent. The kind of the solvent to be used is not limited as long as it does not inhibit the reaction, and examples thereof include methanol, ethanol, toluene, hexane, heptane and the like. These solvents can be used alone or in combination. The amount of the solvent is generally from 1 to 10 ml, and preferably from 3 to 5 ml, based on 1 g of 2-oxo-1-phenyl-3-oxabicyclo[3.1.0]hexane. The reaction temperature is generally from 0 to 100°C, preferably from 20 to 80°C, and particularly preferably from 20 to 30°C, and the reaction time is generally from 3 to 30 hours, although it varies depending on the reaction amount, the reaction temperature or the like. After completion of the reaction, the (Z)-hydroxymethylcyclopropane compound can be obtained by any of known isolation or purification methods in the field or in combination thereof, such as extraction with a solvent, silica gel column chromatography, high performance liquid chromatography, distillation under reduced pressure and recrystaliization. Hereinafter, the present invention will be described in more detail by way of examples, but the present invention is not limited thereto. Preparation Example 1: (Z) -1-phenyl-1-(N,N-diethylaminocarbonyl)-2-hydroxymethylcy clopropane Diethylamine (250.4 g, 3.42 mol) was added to a mixture solution of 2-oxo-1-pheny 1-3-oxabicyclo [3.1.0] hexane (198 . 8 g, 1.14 mol) and toluene (198.8 g) , and a 28% sodium methoxide/methanol solution (660.4 g, 3.42 mol) was added dropwise at 20 to 30°C, followed by stirring for 8 hours. The reaction solution after stirring was added dropwise to a mixture solution of water (554.8 g) and toluene (596.4 ml), and then acetic acid (226.0 g) was added dropwise, followed by separation of the solution. The obtained aqueous layer was extracted again with toluene (397.6 ml). The organic layers were combined, washed with water, and concentrated under reduced pressure to obtain the title compound as a 50% toluene solution. (It was confirmed by HPLC analysis (HPLC: LC-10Avp, ODS column 4 . 6 mm x 150 mm, manufactured by Shimadzu Co.) that the title compound was contained in an amount of 2 65.3 g. The yield was 93.8%.) Example 1: (Z)-1-phenyl-1-(N,N-diethylaminocarbonyl)-2-phthalimidometh ylcyclopropane Ethyl orthoformate (14.4 g, 0.097 mol) was added to a toluene solution (40.0 g) containing (Z)-1-phenyl-1-(N,N-diethylaminocarbonyl)-2-hydroxymethylcy clopropane (20.0 g, 0.081 mol) in a reaction vessel, and then methanesulfonic acid (9.5 g, 0.089 mol) was added dropwise at 15 to 35°C over one hour. After the instillation, the solution was stirred for 1. 5 hours, heated to 40 °C, and concentrated under reduced pressure. N,N-dimethylformamide (20 ml) was added, followed by concentration under the same conditions to obtain a concentrated solution (47.1 g). Separately, phthalimide potassium salt (18.7 g, 0.101 mol) and 92 ml of N, N-dimethylf ormamide were charged in a reaction vessel, and the afore-mentioned concentrated solution was added dropwise to the obtained solution at 40°C over 2 hours, followed by stirring for one hour. The reaction solution was cooled to about 20°C, and water (67.5 ml) was added dropwise to the cooled reaction solution over 3 hours. The mixture was filtered, washed with water (67.5 ml), and dried at about 60°C under reduced pressure to obtain the title compound (28.8 g) as a white crystal. The yield was 93.2% and the purity was 98.6%. Physical data : 1H-NMR(CD3OD, 400MHz) 5: 0.62(3H, t, J=7.0Hz), 1.1K1H, dd, J=5.2, 8.8Hz), 1.17(3H, t, J=7.0Hz), 1.63(1H, dd, J=5.2, 6.0Hz), 2.25(1H, m) , 3.18(1H, m) , 3.30-3.43(3H, m), 3.67(1H, m) , 4.07(1H, dd, J=5.0, 14.2Hz), 7 .21-7 .34 (5H, m) , 7.80-7.89(4H, m). Example 2: (Z)-1-phenyl-1-(N,N-diethylaminocarbonyl)-2-aminomethylcycl opropane hydrochloride Water (35.0 kg) and toluene (79.0 kg) were added to (Z)-1-phenyl-1-(N,N-diethylaminocarbonyl)-2-phthalimidometh ylcyclopropane (18.2 kg, 48. 4mol), and a 40 wt% aqueous solution of monomethylamine (37.7 kg, 485 mol) was added dropwise to the mixture, followed by stirring at 20°C for 20 hours. After separation of the reaction mixture, the aqueous layer was extracted twice with toluene . The organic layers were combined, dried over magnesium sulfate, filtered and then concentrated under reduced pressure. Ethyl acetate (67.1 kg) and isopropyl alcohol (9.0 kg) were added to the concentrated residue, and 4N hydrogen chloride-ethyl acetate (12.5 kg, 55. 9 mol) was added dropwise to a solution thereof. The resulting crystal was filtered, washed with ethyl acetate and dried to obtain (Z)-1-phenyl-1-(N,N-diethylaminocarbonyl)-2-aminomethylcycl opropane hydrochloride (11.9 kg) as a white powder. The yield was 86.9%. Physical data : 1H-NMR(D20, 400MHz) 5:0.87(3H, t, J=7.0Hz), 1.08(3H, t, J=7.0Hz), 1.72-1.84(3H, m) , 2.43(1H, m), 3.25-3.44(4H, m) , 3.71(1H, m) , 7.13-7.28(5H, m) , 8.80(3H, br-s). Example 3: N,N-diethyl-(l-phenyl-3-oxabicyclo[3.1.0]hex-2-ylidene)imin ium methanesulfonate A concentrated solution before conducting phthalimidation was produced in the same manner as in Example 1, and some of the concentrated solution was taken and evaporated to dryness under reduced pressure. After adding n-heptane to the residue, a decantation operation was repeated several times, followed by evaporation to dryness under reduced pressure to obtain the title compound as a water-soluble pale yellow oil (purity: 98.6%). Physical data : 1H-NMR(D20, 400MHz) 5: 0.26(3H, t, J=7.2Hz), 0.71(3H, t, J=7.2Hz), 1.14(1H, m) , 1.90(1H, m) , 2.18(1H, m) , 2.24(3H, s), 2.75(1H, m), 2.95(1H, m) , 3.13(2H, m) , 4.30(1H, d, J=9.6Hz), 4.57(1H, dd, J=4.8, 9.6Hz), 6.93-7.00(5H, m). LC-MS(ESI, transfer phase: acetonitrile 0.1% aq. CF3C02H) M+1: 344 (detected by trifluoroaceticacid salt) CI-MS: M+1 326 According to the present invention, in the case of producing the (Z)-phthalimidomethylcyclopropane compound, a chlorination agent, which generates sulfur dioxide during the reaction, is not required because a chloro compound or an acid chloride is not by way of the reaction, unlike a conventional method. Furthermore, it is not required to use a low boiling point halogenated hydrocarbon solvent such as dichloroethane, which may cause an environmental problem. Also, as compared to the case where a chlorination agent is used, coloration of the product can be suppressed and thus the process of the present invention is excellent as a process for producing an intermediate of drugs. Furthermore, since a first step and a second step are conducted in the same reaction vessel, one step can substantially be omitted, and thus the process of the present invention is also excellent in economy. WE CLAIM 1. A process for producing (Z)-1-phenyl-1-(N,N-di-ethylaminocarbonyl)-2- phthalimidomethylcyclopro-pane which comprises reacting (Z)-1-phenyl-1-(N, N- diethylaminocarbonyl)-2-hydroxymethylcyclopro-pane with an orthoester and a br0nsted acid selected from methanesulfonic acid, toluenesulfonic acid, tri- fluoromethanesulfonic acid, sulfuric acid and hydrogen chloride; and then reacting the reaction product with a phthalimidating agent. 2. The process as claimed in Claim 1, wherein the reaction product of (Z)-1-phenyl-1-(N,N- diethylamino-carbonyl)-2-hydroxymethylcyclopropane, an orthoester and a br0nsted acid is an iminium salt of the formula (I) wherein A" represents conjugated base of br0nsted acid, which br0nsted acid is as defined in claim 1. 3. The process as claimed in Claim 1, wherein the br0nsted acid is methanesulfonic acid. 4. The process as claimed in Claim 1, wherein the orthoester is an orthoformic alkyl ester. 5. The process as claimed in Claim 4, wherein the orthoformic alkyl ester is triethyl orthoformate ortrime-thyl orthoformate. 6. The process as claimed in Claim 1, wherein the phthalimidating agent is (1) phthalimide potassium salt or (2) phthalimide and a base. 7. The process as claimed in Claim 6, wherein the base is at least one selected from the group consisting of potassium tert-butoxide, sodium methoxide, potassium carbonate and triethylamine. 8. The process as claimed in Claim 1, which comprises obtaining the (Z)-1-phenyl-1-(N,N- diethylaminocar-bonyl)-2-hydroxymethylcyclopropane by reacting 2-oxo-1-phenyl-3- oxabicyclo[3.1.0]hexane with di-ethylamine in the presence of an alkali metal alkox- ide. 9. A process for producing (Z)-1-phenyl-1-(N,N-di-ethylaminocarbonyl)- 2- aminomethylcyclopropane hydrochloride which comprises a step of reacting (Z)-1- phenyl- 1-(N, N- diethylaminocarbonyl)- 2- hy-droxymethylcyclopropane with an orthoester and a bransted acid selected from methanesulfonic acid, toluenesulfonic acid, trifluoromethanesulfonic acid, sulfuric acid and hydrogen chloride to obtain a reaction product, a step of reacting the reaction product with a phthalimidating agent to obtain (Z)-1-phenyl-1-(N, N- diethylaminocarbonyl)-2- phthalimidometh- ylcyclopropane, a step of reacting (Z)-l -phenyl-1 -(N, N- diethylaminocarbonyl)- 2- phthalimidomethylcy-clopropane with aqueous methylamine to obtain (Z)-1- phenyl-1- (N, N- diethylaminocarbonyl)- 2- aminomethylcyclopropane, and a step of treating (Z)-l -phenyl- 1-(N, N- diethylaminocarbonyl)- 2- ami-nomethylcycl opropane with hydrogen chloride. 10. An iminium salt of the formula (I) as claimed in claim 2 wherein A represents conjugated base of a br0nsted acid, which bransted acid is selected from methanesulfonic acid, toluenesulfonic acid, trifluoromethanesulfonic acid, sulfuric acid and hydrogen chloride. 11. The iminium salt as claimed in Claim 10, wherein A" is CH3SO3-. ABSTRACT Title:- "PROCESS FOR PRODUCING (Z)-1-PHENYL-1-(N,N- DIETHYLAMINOCARBONYL)-2-PHTHALIMIDOMETHYLCYCLOPROPANE." The present invention provides a process for producing (z)-1-phenyl-1-(N,N- diethylaminocarbonyl)-2-phthalimidomethylcyclopropane, which includes reacting (z)-1- phenyl-1-(N,N-diethylaminocarbonyl)-2-aminomethylcycl opropane hydrochloride through the above process.

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